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HiGee process intensification in biorefineries: innovations, challenges, and outlook 生物炼制过程强化:创新、挑战与展望
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-27 DOI: 10.1016/j.coche.2025.101119
Kamelia Boodhoo, Fernando Russo Abegão
Biorefineries will play a crucial role in the circular and net-zero economies of the future. To enable these sustainable factories to thrive, it is essential to overcome processing challenges associated with streams complexity, variability, degree of dilution and stability of products, amongst others. Process intensification strategies based on centrifugal force fields or high gravity (HiGee) fields provide promising solutions for rapid heat and mass transfer in fast reactions and/or systems where mixing of fluids is challenging. The applications of HiGee intensification techniques to biorefining processes for oil and sugar solutions, multiphase systems using liquid–liquid or solid suspension streams and thermochemical processes amongst others are highlighted in this short review. The state of the art and the current technology successes and limitations are discussed, identifying key areas for future development and providing an outlook for industrial uptake.
生物精炼厂将在未来的循环经济和净零经济中发挥关键作用。为了使这些可持续工厂蓬勃发展,必须克服与溪流复杂性、可变性、稀释程度和产品稳定性等相关的处理挑战。基于离心力场或高重力(HiGee)场的过程强化策略为快速反应和/或流体混合具有挑战性的系统中的快速传热和传质提供了有希望的解决方案。在这篇简短的综述中,重点介绍了highee强化技术在油和糖溶液的生物精炼过程、使用液-液或固体悬浮流的多相系统以及热化学过程等方面的应用。讨论了目前的技术状况和当前技术的成功和局限性,确定了未来发展的关键领域,并提供了工业吸收的前景。
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引用次数: 0
Advancement in innovative strategies for poly (ethylene terephthalate) biodegradation 聚对苯二甲酸乙酯生物降解创新策略研究进展
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-26 DOI: 10.1016/j.coche.2025.101121
Anamika Kushwaha, Lalit Goswami, Beom Soo Kim
The present review thoroughly illustrates the recent advancements in the innovative strategies of poly (ethylene terephthalate) (PET) biodegradation. It encompasses the involvement of the optimization of pretreatment process, microbes-mining, mixed strain/multi-enzyme approach, supplementation of auxiliary agents, enzyme and molecular engineering, and so on, with further delving into the inclusion of smarter technologies such as computational modeling, molecular mechanics, docking simulation, and machine learning. Finally, the review anticipates rejuvenating the traditional PET biodegradation process, offering more advanced, sustainable, green, fast, economic, and efficient techniques for PET biodegradation.
本文综述了近年来聚对苯二甲酸乙酯(PET)生物降解创新策略的研究进展。它涉及预处理工艺优化、微生物挖掘、混合菌株/多酶方法、助剂补充、酶和分子工程等,并进一步深入到包括计算建模、分子力学、对接模拟和机器学习等智能技术。最后,展望了传统PET生物降解工艺的复兴,为PET生物降解提供更先进、可持续、绿色、快速、经济和高效的技术。
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引用次数: 0
A review on scale-up approaches for ultrasound-assisted extraction of natural products 超声辅助提取天然产物的放大方法综述
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-22 DOI: 10.1016/j.coche.2025.101120
Vitoria H Cauduro , Gustavo Gohlke , Nicole W da Silva , Adriano G Cruz , Erico MM Flores
The extraction of bioactive compounds from natural sources is a topic of great interest. In this sense, ultrasound-assisted extraction (UAE) has emerged as a promising technology for fast and efficient extraction of natural products without high organic solvent consumption. However, most studies on UAE are focused on laboratory scale. In order for this technology to be suitable for industrial applications, more pilot studies need to be developed and discussed. In this sense, this review aimed to address scale-up applications of UAE of natural products developed from 2019 to the first semester of 2024. Applications involving hydrodynamic cavitation were not included in this review. Key parameters related to ultrasound were addressed, such as reactor configuration, process type (batch or continuous), frequency, and others. Furthermore, the major challenges associated with the upscaling of UAE, as well as current trends and future perspectives were discussed. It was observed that flow cells were the main reactor type used in scale-up UAE of natural products and that flow-through was the main operation mode. The use of these devices enabled processing of higher sample volumes, possibly due to more homogeneous energy distribution in the reactor. Hence, further enhancements in this area should be expected. Furthermore, phenolic compounds were the main targets of extraction and low frequencies (<100 kHz) were used. However, a challenge remains regarding the lack of essential information in several publications, which makes comparison between studies difficult, as well as their reproduction. Nevertheless, scale-up UAE of natural products is a promising research area.
从天然资源中提取生物活性化合物是一个非常有趣的话题。从这个意义上说,超声辅助提取(UAE)已经成为一种有前途的技术,可以快速有效地提取天然产物,而不需要消耗大量的有机溶剂。然而,大多数关于阿联酋的研究都集中在实验室规模上。为了使该技术适用于工业应用,需要开展和讨论更多的试点研究。从这个意义上说,本综述旨在解决2019年至2024年上半年开发的天然产品在阿联酋的大规模应用问题。涉及流体动力空化的应用未包括在本综述中。讨论了与超声相关的关键参数,如反应器配置、工艺类型(间歇或连续)、频率等。此外,还讨论了与阿联酋升级相关的主要挑战,以及当前趋势和未来前景。结果表明,流动池是天然产物放大生产中使用的主要反应器类型,流动池是主要的操作方式。使用这些装置可以处理更高的样品体积,可能是由于反应器中更均匀的能量分布。因此,应该期望在这方面有进一步的增强。此外,酚类化合物是提取的主要目标,并使用低频率(<100 kHz)。然而,仍然存在一个挑战,即一些出版物中缺乏基本信息,这使得研究之间的比较和复制变得困难。然而,扩大天然产品的规模是一个有前途的研究领域。
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引用次数: 0
Techniques for kinetic parameter estimation in free radical polymerization models 自由基聚合模型动力学参数估计技术
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-12 DOI: 10.1016/j.coche.2025.101117
Lauren A Gibson, Kimberley B McAuley
Free radical polymerization (FRP) systems can have many reactions, leading to many kinetic parameters. The most common method to obtain values for kinetic parameters is weighted-least squares estimation, which uses multiple types of measured responses. Error-in-variables model estimation is used when there is significant uncertainty in the model inputs. When FRP models have many unknown parameters, it is difficult to estimate them all uniquely, so modelers often resort to model simplification or subset selection methods for parameter estimation. The aim of this review is to describe the most common techniques that modelers use for kinetic parameter estimation in FRP models.
自由基聚合(FRP)体系可以有许多反应,导致许多动力学参数。获得动力学参数值最常用的方法是加权最小二乘估计,它使用多种类型的测量响应。当模型输入中存在显著的不确定性时,使用变量误差模型估计。当FRP模型有许多未知参数时,很难对它们进行唯一估计,因此建模者通常采用模型简化或子集选择方法进行参数估计。这篇综述的目的是描述建模者在FRP模型中用于动力学参数估计的最常用技术。
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引用次数: 0
Recent trends in optimization models for industrial decarbonization 工业脱碳优化模型的最新趋势
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-11 DOI: 10.1016/j.coche.2025.101118
Raymond R Tan , Maria Victoria Migo-Sumagang , Kathleen B Aviso
The global call for deep decarbonization poses the critical challenge of cutting greenhouse gas emissions from industrial operations. Decarbonization can be achieved with a mix of strategies and technologies, but decision-support models are needed to help optimize their emissions reduction portfolios. This review surveys the development and use of models to support industrial decarbonization decisions and proposes a research roadmap for the future. Four key modeling challenges are identified: epistemic uncertainties inherent in new technologies, feedback loops between techno-economic performance and technology selection, the interplay between multiple decision-makers, and embedding within a broader decarbonization context.
全球对深度脱碳的呼吁提出了减少工业运营温室气体排放的关键挑战。脱碳可以通过战略和技术的组合来实现,但需要决策支持模型来帮助优化其减排组合。本文综述了支持工业脱碳决策的模型的发展和使用,并提出了未来的研究路线图。确定了四个关键的建模挑战:新技术固有的认知不确定性,技术经济绩效和技术选择之间的反馈循环,多个决策者之间的相互作用,以及嵌入更广泛的脱碳背景。
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引用次数: 0
Nanoplastic mitigation technologies: challenges and sustainability considerations 纳米塑料减缓技术:挑战和可持续性考虑
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-08 DOI: 10.1016/j.coche.2025.101107
Nisha Singh , Nitin Khandelwal , Ryota Nakajima , Amina K Stoddart , Graham A Gagnon
The rise of plastic pollution has led to widespread environmental contamination by their tiny fragments, posing alarming environmental threats and health risks. Nanoplastics, NPs (<1000 nm) are particularly concerning due to their enhanced reactivity, potential to cross biological barriers and complex interactions with environmental matrices. Laboratory studies rely heavily on synthetic polystyrene beads, despite polystyrene constituting only 4.5% of global plastic production. Real-world NPs exist as hetero-aggregates with eco-corona layers, significantly altering their reactivity and toxicity. Furthermore, NPs interact with heavy metals and organic pollutants, modifying their fate and altering transport and remediation outcomes.
This perspective discusses the limitations of current water treatment plant (WTP) processes, highlighting emerging mitigation technologies, associated challenges, and the possibility of their incorporation into existing treatment settings. Enhanced adsorption, nano-enabled membrane filtration, photocatalytic degradation, magnetic microrobots, emulsions, deep eutectic solvents, and plasma technology show initial promise but face challenges like integration in existing treatment setups, high costs, regeneration difficulties, and potential for secondary pollution. Future research should focus on adapting mitigation techniques to diverse environmental matrices and their integration into existing setups, ensuring sustainability and resource recovery while achieving complete mineralization or recovery of NPs.
塑料污染的增加导致其微小碎片广泛污染环境,构成了令人担忧的环境威胁和健康风险。纳米塑料,NPs (<1000 nm)由于其增强的反应性,跨越生物屏障的潜力以及与环境基质的复杂相互作用而特别受到关注。尽管聚苯乙烯仅占全球塑料产量的4.5%,但实验室研究严重依赖合成聚苯乙烯珠。现实世界的NPs以异聚集体的形式存在,具有生态电晕层,显著改变了它们的反应性和毒性。此外,NPs与重金属和有机污染物相互作用,改变了它们的命运,改变了运输和修复结果。这一观点讨论了当前水处理厂工艺的局限性,强调了新兴的缓解技术、相关挑战以及将其纳入现有处理环境的可能性。增强型吸附、纳米膜过滤、光催化降解、磁性微型机器人、乳剂、深度共晶溶剂和等离子体技术显示出最初的前景,但面临着诸如现有处理装置的集成、高成本、再生困难和潜在的二次污染等挑战。未来的研究应侧重于使缓解技术适应不同的环境基质,并将其纳入现有的设置,确保可持续性和资源回收,同时实现NPs的完全矿化或回收。
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引用次数: 0
A review of the application and future directions of high-power ultrasonic technology in environmental protection 综述了大功率超声技术在环境保护中的应用及未来发展方向
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-04 DOI: 10.1016/j.coche.2025.101105
JunJie Ma , Juanjuan Wang , Fulei Xu , Xiaoge Wu
This review delves into the growing importance of power ultrasonic technology in the field of environmental protection, with a focus on its applications in wastewater treatment. It discusses various commercial transducer types, including piezoelectric, MEMS-based, air-coupled, high-frequency thin-film, magnetostrictive, and hybrid transducers, each with distinct characteristics and specific applications. The paper further assesses the effectiveness of power ultrasound in water treatment and resource recycling. Although power ultrasonic technology is still in the developmental stage and faces challenges such as high initial costs and energy consumption, this review looks to the future by identifying potential directions, such as the combination of power ultrasound with other advanced processes like catalytic oxidation and ozonation to further enhance treatment efficiency. It also emphasizes the integration of artificial intelligence and machine learning for process optimization.
本文综述了动力超声技术在环境保护领域日益重要的作用,重点介绍了其在废水处理中的应用。它讨论了各种商用换能器类型,包括压电、mems、空气耦合、高频薄膜、磁致伸缩和混合换能器,每种换能器都具有不同的特性和特定的应用。本文进一步评价了功率超声在水处理和资源回收中的有效性。虽然功率超声技术仍处于发展阶段,面临着初始成本高、能耗大等挑战,但本文展望了未来的发展方向,如功率超声与催化氧化、臭氧化等其他先进工艺相结合,进一步提高处理效率。它还强调人工智能和机器学习的集成,以实现流程优化。
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引用次数: 0
Editorial overview: Digital design of pharmaceutical manufacturing processes 编辑概述:制药生产过程的数字化设计
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-03-04 DOI: 10.1016/j.coche.2025.101108
Kimberley B McAuley , Jonathan P McMullen , Salvador Garcia Muñoz
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引用次数: 0
Membranes from upcycled waste plastics: current status, challenges, and future outlook 再生塑料膜:现状、挑战和未来展望
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-02-22 DOI: 10.1016/j.coche.2025.101106
Milad R Esfahani , Steven T Weinman
Plastic is ubiquitous across all aspects of modern life. Despite its usefulness, only 9% of all plastic waste ever produced has been recycled, leaving a tremendous amount that ends up in landfills and the environment. New strategies need to investigate using this waste plastic. This report analyzes upcycling waste plastics into membranes for water and gas separations. Polyethylene terephthalate, polystyrene, poly(vinyl chloride), polyethylene, polypropylene, and tire rubber have been studied for use as membranes. Future work needs to investigate greener solvents, health and safety aspects, costs, supply and demand, and life cycle assessments for upcycling plastic waste into membranes.
塑料在现代生活的方方面面无处不在。尽管它很有用,但只有9%的塑料垃圾被回收利用,留下了大量的垃圾填埋场和环境。需要研究使用这种废塑料的新策略。本报告分析了将废塑料升级为膜用于水和气体分离。聚对苯二甲酸乙二醇酯、聚苯乙烯、聚氯乙烯、聚乙烯、聚丙烯和轮胎橡胶已被研究用作膜。未来的工作需要研究更环保的溶剂、健康和安全方面、成本、供应和需求,以及将塑料废物升级为膜的生命周期评估。
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引用次数: 0
Using advanced X-ray spectroscopy to reveal molecular level insights into water treatment 使用先进的x射线光谱学揭示水处理分子水平的见解
IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pub Date : 2025-02-20 DOI: 10.1016/j.coche.2025.101103
Hande Demir , Pinar Aydogan Gokturk , Ethan J Crumlin
Water treatment technologies separate relevant solutes from water resources for water reuse, valuable resource recovery, and increasing the equity and availability of clean water worldwide. Although a variety of treatment methods exist, their performance needs to be improved to enable selective separation with increased durability and fouling resistance. To achieve this, we need to gain a better understanding of how molecular-level physics and chemistry impact integrated systems. Regarding current research on water treatment techniques, there is a clear need to study such systems under realistic environmental conditions. In this review, we aim to show that X-ray spectroscopic techniques are uniquely positioned to provide such information by obtaining detailed molecular insight into phenomena relevant to water research. By doing so, we hope to accelerate the rational design of novel treatment materials and processes. Specifically, a deeper understanding of the complex and interconnected phenomena that impact multilevel water treatment processes will lead to the successful development of next-generation water purification technologies.
水处理技术将相关的溶质从水资源中分离出来,用于水的再利用,回收有价值的资源,并在全球范围内增加清洁水的公平性和可用性。虽然存在多种处理方法,但它们的性能需要改进,以实现选择性分离,增加耐用性和抗污性。为了实现这一点,我们需要更好地理解分子水平的物理和化学是如何影响集成系统的。就目前的水处理技术研究而言,显然需要在现实环境条件下研究这种系统。在这篇综述中,我们的目的是展示x射线光谱技术的独特定位,通过获得与水研究相关的现象的详细分子洞察力来提供这些信息。通过这样做,我们希望能加速新型处理材料和工艺的合理设计。具体来说,对影响多级水处理过程的复杂和相互关联的现象的更深入的理解将导致下一代水净化技术的成功发展。
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引用次数: 0
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Current Opinion in Chemical Engineering
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