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Laser additive manufacturing technology in titanium 64 implant of microstructure fabrication and analysis 激光增材制造技术在钛64植入体中的微结构制备及分析
S. Lin, C. C. Lin, D. Lin, C. Chuang
Laser additive manufacturing technology is very attractive for industry applications due to the characterizations of rapid manufacture, flexible parameters select, customize, and complex 3D object fabricate. In this article, an EOS M-type direct metal laser sintering (DMLS) system was used to manufacture for customized hip implant with an IPG fiber laser. The part building process takes place inside an enclosed chamber filled with argon gas to minimize oxidation powdered material. We are successful design and producing an implant of imitation bone microstructure in titanium alloy. From the SEM analysis image, an approximately 100% dense surface has be observed. The mainly composition of selective laser additive manufacturing product are acicular structure of alpha-phase titanium. X-ray diffraction patterns also are observed the alpha-phase and beta-phase mixture. This customized hip implant is used to clinical application for replacement the golden retriever's femoral head, and it get good results. Imitation bone structure can promote the biocompatible of titanium material and bone.
激光增材制造技术具有制造速度快、参数选择灵活、可定制化、三维物体加工复杂等特点,在工业应用中具有很大的吸引力。本文采用EOS m型直接金属激光烧结(DMLS)系统,利用IPG光纤激光器制造定制髋关节假体。零件制造过程在一个充满氩气的封闭室中进行,以尽量减少氧化粉末材料。我们成功地设计并生产了一种仿骨微结构钛合金种植体。从SEM分析图像中,可以观察到大约100%的致密表面。选择性激光增材制造产品的主要成分是针状结构的α相钛。x射线衍射图也被观察到相和相混合物。该定制髋关节假体用于金毛猎犬股骨头置换术的临床应用,取得了良好的效果。仿骨结构可促进钛材料与骨的生物相容性。
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引用次数: 12
Low-cost rapid prototyping of flexible plastic paper based microfluidic devices 基于柔性塑料纸的微流体装置的低成本快速成型
Yiqiang Fan, Huawei Li, Ying Yi, I. Foulds
This research presents a novel rapid prototyping method for paper-based flexible microfluidic devices. The microchannels were fabricated using laser ablation on a piece of plastic paper (permanent paper), the dimensions of the microchannels was carefully studied for various laser powers and scanning speeds. After laser ablation of the microchannels on the plastic paper, a transparent poly (methyl methacrylate)(PMMA) film was thermally bonded to the plastic paper to enclose the channels. After connection of tubing, the device was ready to use. An example microfluidic device (droplet generator) was also fabricated using this technique. Due to the flexibility of the fabricated device, this technique can be used to fabricate 3D microfluidic devices. The fabrication process was simple and rapid without any requirement of cleanroom facilities.
本研究提出了一种新型的纸基柔性微流体器件快速成型方法。采用激光烧蚀法在塑料纸(永久纸)上制备微通道,研究了不同激光功率和扫描速度下微通道的尺寸。激光烧蚀塑料纸上的微通道后,一层透明的聚甲基丙烯酸甲酯(PMMA)薄膜被热粘合在塑料纸上,以封闭通道。连接油管后,设备就可以使用了。并利用该技术制作了微流控装置(液滴发生器)的实例。由于所制备器件的灵活性,该技术可用于制备三维微流体器件。制备过程简单、快速,不需要任何洁净室设施。
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引用次数: 3
Close-loop self-compensation of the coupling error for silicon micromachined gyroscope 硅微机械陀螺仪耦合误差的闭环自补偿
Jianbin Su, D. Xiao, Xuezhong Wu, Zhihua Chen, Z. Hou
This paper presents the detailed analysis and preliminary design and experiment for close-loop self-compensation of the coupling error for silicon micromachined gyroscope. A closed-loop feedback control technology is adopted, which uses electrostatic force to counteract the change of coupling stiffness. The electrostatic force is generated by the detection variation of coupling error. Comparing with the open-loop detection, the experimental results indicated evidently that the proposed method can effectively decrease the value of the coupling error, increase its stability by 38 times, while the scale factor of the microgyroscope remains unchanged.
本文对硅微机械陀螺仪的耦合误差闭环自补偿进行了详细的分析、初步设计和实验。采用闭环反馈控制技术,利用静电力抵消耦合刚度的变化。静电力是由耦合误差的检测变化产生的。与开环检测相比,实验结果表明,该方法在保持微陀螺尺度因子不变的情况下,有效地降低了耦合误差值,稳定性提高了38倍。
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引用次数: 1
Cantilever arrayed blood pressure sensor for arterial applanation tonometry 用于动脉压平测压的悬臂式阵列血压传感器
Byeungleul Lee, Jinwoo Jeong, Chanseob Cho, Jinseok Kim, Bonghwan Kim, H. Kim, K. Chun
We developed a cantilever-arrayed blood pressure sensor array fabricated by (111) silicon bulk-micromachining for the noninvasive and continuous measurement of blood pressure. The blood pressure sensor measures the blood pressure based on the change in resistance of the piezoresistor on a 5-μm-thick-arrayed perforated membrane and 20-μm-thick metal pads. The length and width of the unit membrane are 210 and 310 μm, respectively. The width of the insensible zone between adjacent units is only 10 μm. The resistance change over contact force was measured to verify the performance. The good linearity of the result confirmed that the PDMS package transfers the forces appropriately. The measured sensitivity was about 4.5%/N. The maximum measurement range and resolution of the fabricated blood pressure sensor were greater than 900 mmHg and less than 1 mmHg, respectively.
我们开发了一种由(111)硅体微加工制成的悬臂式血压传感器阵列,用于无创连续测量血压。血压传感器是在5 μm厚的穿孔膜和20 μm厚的金属垫片上,通过压敏电阻的电阻变化来测量血压。单元膜的长度为210 μm,宽度为310 μm。相邻单元之间的不敏感区宽度仅为10 μm。通过测量电阻随接触力的变化来验证其性能。结果良好的线性关系证实了PDMS包能很好地传递力。测得的灵敏度约为4.5%/N。所制血压传感器的最大测量范围大于900 mmHg,分辨率小于1 mmHg。
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引用次数: 8
Three dimensional compensation spherical coils for compact atomic magnetometers 紧凑型原子磁力仪用三维补偿球形线圈
C. Zhuo, H. Dong, L. Xuan
To avoid the broadening of Zeeman resonances of the vector atomic magnetometer working in an unshielded environment, the rapid and accurate magnetic compensation is necessary. A three dimensional mini spherical compensating system is presented, which can be used together with a chip-scale atomic magnetometer to realize an ultra-high precision field measurement. Based on the field gradient method, parameters are optimized to obtain a uniformity of 10-3 over the region of one half radius with a good tolerance on dimensional variations. A prototype applied in the single laser beam scheme has been built and the experimental results demonstrate the validity of the design.
为了避免矢量原子磁强计在无屏蔽环境下工作时塞曼共振的展宽,需要对矢量原子磁强计进行快速准确的磁补偿。提出了一种三维微型球面补偿系统,该系统可与芯片级原子磁强计配合使用,实现超高精度的磁场测量。基于场梯度法对参数进行了优化,在半半径范围内得到了10-3的均匀性,对尺寸变化有良好的容错能力。建立了应用于单光束方案的原型机,实验结果证明了该设计的有效性。
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引用次数: 1
Superhydrophobic surface obtained using pyramidal PTFE film fabricated on RIE etched silicon 在RIE蚀刻硅上制备锥体聚四氟乙烯薄膜获得超疏水表面
C. Baek, Litao Yao, S. Seo, Hwa-Min Kim, D. Pyo, Pyo-Hwan Hong, Jung-Hwa Oh, D. Kong, Chanseob Cho, Jong-Hyun Lee, In-Yong Eom, Bonghwan Kim
We have developed a surface texturing process using a polytetrafluoroethylene coating with a pyramidal structure for obtaining superhydrophobic surfaces. In order to investigate the hydrophobic properties of the surface, we measured the contact angle and roughness values. The calculated roughness factor and root mean square roughness ranged from 2.47 to 2.6 and from 0.25 μm to 0.4 μm, respectively. The contact angle of a water droplet on the surface was greater than 150°; moreover, this angle was maintained for over 7 weeks. This observation implies that extremely low wettability is achievable on superhydrophobic surfaces.
我们开发了一种表面纹理工艺,使用具有锥体结构的聚四氟乙烯涂层来获得超疏水表面。为了研究表面的疏水性,我们测量了接触角和粗糙度值。计算得到的粗糙度系数和均方根粗糙度分别在2.47 ~ 2.6和0.25 ~ 0.4 μm之间。水滴与表面的接触角大于150°;而且,这个角度保持了7周以上。这一观察结果表明,在超疏水表面上可以实现极低的润湿性。
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引用次数: 1
Influence of substrate surface roughness on the properties of a planar-type CO2 sensor using evaporated Li3PO4 film 衬底表面粗糙度对蒸发Li3PO4薄膜平面型CO2传感器性能的影响
Hairong Wang, Peng Li, G. Sun, Zhuangde Jiang
Planar-type potentiometric CO2 gas sensors using thermal evaporated Li3PO4 thin film as the solid electrolyte were fabricated. Al2O3 plates with rough and smooth surfaces were used as the substrates of the sensors. X-ray diffraction analysis, atomic force microscope and scanning electron microscope were used to characterize the Li3PO4 films. The sensing properties were investigated in the range of 500~5000 ppm CO2 concentrations at 480 °C. Both the rough substrate sensor (rsensor) and the smooth substrate sensor (s-sensor) showed a good Nernst behavior. The output EMF of s-sensor showed a more stable signal than the r-senor. Response and recovery times of the r-sensor were 40 s and 75 s, and for the s-sensor they were 35 s and 60 s. The ΔEMF/decade values obtained from the r-sensor and s-sensor were 45 mV/decade and 55 mV/decade, respectively. It can be found that the Nernst's slop of the s-sensor was closer to the theoretically value. The results revealed that the substrate surface roughness may influence the characteristics of Li3PO4 film and the response properties of the sensors to CO2.
采用热蒸发Li3PO4薄膜作为固体电解质,制备了平面型CO2电位传感器。采用表面粗糙和光滑的Al2O3板作为传感器的衬底。采用x射线衍射分析、原子力显微镜和扫描电镜对Li3PO4薄膜进行了表征。在480℃下,在CO2浓度为500~ 5000ppm的范围内研究了其传感性能。粗糙衬底传感器(rsensor)和光滑衬底传感器(s-sensor)均表现出良好的能思行为。s型传感器输出的电动势信号比r型传感器更稳定。r-传感器的响应和恢复时间分别为40 s和75 s, s-传感器的响应和恢复时间分别为35 s和60 s。r-传感器和s-传感器得到的ΔEMF/decade值分别为45 mV/decade和55 mV/decade。可以发现s型传感器的能斯特斜率更接近理论值。结果表明,衬底表面粗糙度会影响Li3PO4薄膜的特性和传感器对CO2的响应特性。
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引用次数: 1
Metal-catalyst free integration of SiO2 nanowires into carbon MEMS 二氧化硅纳米线在碳MEMS中的无金属催化剂集成
Liangliang Xu, T. Shi, S. Xi, Hu Long, Shiyuan Liu, Zirong Tang
This paper presents an innovative technique of integrating silica nanowires to photoresist-derived carbon microelectromechanical systems (C-MEMS) on silicon substrate. The silica nanowires were synthesized through thermal treatment in a tube furnace at 1200 °C under a gaseous environment of N2 and H2. The stiff morphology and radicalized distribution around carbon posts of nanowires was observed, which was different from much of the previous studies. High-temperature annealing and meticulous-controlled pyrolying atmosphere could be the causes of the formation of unusual SiO2/C-MEMS integrated structures.
提出了一种将二氧化硅纳米线集成到硅衬底光敏电阻衍生碳微机电系统(C-MEMS)的创新技术。在1200℃的管式炉中,在N2和H2气体环境下进行热处理,合成了二氧化硅纳米线。观察到纳米线碳柱周围的刚性形态和自由基分布,这与以往的许多研究不同。高温退火和精心控制的热解气氛可能是形成不同寻常的SiO2/C-MEMS集成结构的原因。
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引用次数: 0
Quantitative characterization of specific targeting of tumor cells by antibody-functionalized particles 抗体功能化颗粒特异性靶向肿瘤细胞的定量表征
M. T. Stamm, Andrew S. Trickey-Glassman, Linan Jiang, Y. Zohar
Receptor-ligand binding has been one of the more popular approaches to specifically targeting tumor cells. In this work, targeting efficiency was quantitatively characterized using silica particles functionalized with EpCAM antibodies and EpCAM-expressing BT-20 breast cancer cells. The effects of incubation time and particle concentration on the number of functionalized particles bound to target cells were experimentally investigated. The number of bound particles was found to increase with particle concentration, but not necessarily with incubation time. While particle desorption and cellular loss of binding affinity in time seem to be negligible, cell-particle-cell interaction was identified as the limiting mechanism for the number of particles bound to target cells. The current findings suggest that separation of a bound particle from a cell may be detrimental to cellular binding affinity.
受体-配体结合是目前比较流行的靶向肿瘤细胞的方法之一。在这项工作中,利用EpCAM抗体功能化的二氧化硅颗粒和表达EpCAM的BT-20乳腺癌细胞,定量表征了靶向效率。实验研究了孵育时间和颗粒浓度对结合靶细胞的功能化颗粒数量的影响。结合颗粒的数量随颗粒浓度的增加而增加,但与孵育时间无关。虽然颗粒解吸和细胞在时间上的结合亲和力损失似乎可以忽略不计,但细胞-颗粒-细胞相互作用被认为是结合靶细胞的颗粒数量的限制机制。目前的研究结果表明,结合颗粒从细胞中分离可能对细胞结合亲和力有害。
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引用次数: 2
Polymeric hemispherical pico-liter micro cups fabricated by inkjet printing 用喷墨印刷制造的聚合物半球形微杯
L. Jacot-Descombes, M. Gullo, V. Cadarso, M. Mastrangeli, J. Brugger
The fabrication of precise hemispherical shape is challenging with standard planar lithography techniques. A suitable alternative is the fabrication by inkjet printing. This paper presents a method based on drop-on-demand inkjet printing on pre-patterned silicon substrates allowing the controlled fabrication of SU-8 hemispherical cup-like structures with inner cavities of sub-nano-liter volumes. Examples are given for cups of 100μm in diameter with inner cavity volumes of 5pL, 20pL and 45pL. Arrays of 360 hemispherical SU-8 cups have been fabricated with a yield above 96%. The 4% of exceptions are also described and shown as a method for achieving almost complete SU-8 spheres.
用标准平面光刻技术制造精确的半球形是具有挑战性的。一种合适的替代方法是通过喷墨印刷制造。本文提出了一种在预图型硅衬底上按需喷墨打印的方法,可以控制制造具有亚纳升体积内腔的SU-8半球形杯状结构。给出了直径为100μm、内腔体积为5pL、20pL和45pL的杯子的例子。已制成360个半球形的SU-8杯阵列,产率在96%以上。4%的例外也被描述并显示为实现几乎完整的SU-8球体的方法。
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引用次数: 2
期刊
The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
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