Greenhouse gas (GHG) inventories serve as the data foundation for climate change mitigation; however, large-scale inventories primarily rely on macro-level energy consumption data, possessing limited spatial resolution and GHG type, and the top-down allocation of emissions introduces further uncertainty. To provide a comprehensive analysis of anthropogenic GHGs emissions in China, we established a district-county-level emission database for 2021, encompassing CO2, CH4, N2O, CF4, C2F6, and HFC-23, utilizing the bottom-up approach that integrates extensive point source data. Emission characteristics were analyzed through energy and emission flows, spatial distribution, industrial contributions, and emission intensity. Total GHGs emissions were calculated at 13.92 Gt CO2eq, with CO2 comprising 85.84 %, followed by CH4 at 9.22 % and N2O at 3.12 %. The analysis revealed that energy activity contributed 80.91 % of total GHGs emissions, with coal consumption alone responsible for approximately half of CO₂ emissions. Spatially, higher emissions were observed in districts and counties in the northern regions and the eastern and southern coastal areas. GHGs emissions from 42 major industries totaled 10.88 Gt CO2eq, with the top seven industries representing over 95 %. The national average GHGs emission intensity and industrial one was 121.74 and 292.05 Kt CO2eq/billion CNY, respectively. Notably, economic growth in North China and Northwest is more reliant on high‑carbon industries. Furthermore, regional disparities in industrial structure, energy mix, and economic development contribute to varying emphases among provinces in mitigating emissions per unit of energy consumption.