Majalah Obat Tradisional最新文献

{"title":"Isolation and Identification of β-sitosterol, 7-hydroxystigmast-22-en-3,6-dione and 3β, 24(S)-dihydroxycholesta-5, 25-diene-7-one from stem bark of Nauclea pobeguinii","authors":"A. J. Adepoju, S. Oladoye, E. T. Ayodele, Adeola Victoria Falade, G. Lim, C. Oo","doi":"10.22146/mot.77324","DOIUrl":"https://doi.org/10.22146/mot.77324","url":null,"abstract":"The stem bark of the Nauclea pobeguinii was collected, air-dried, and pulverized and was extracted with solvent of varying polarity (n-hexane, ethyl acetate, and ethanol) to obtain the crude extracts. Silica gel column and thin layer chromatographic separation afforded three compounds whose structures were elucidated as β-sitosterol (1), 7-hydroxystigmast-22-en-3.6-dione (2), and 3β, 24(S)-dihydroxycholesta-5, 25-dien-7-one (3) by analysis of their chemical and spectral characteristic from 1D and 2DNMR, FTIR and by comparing of data with those reported in the literature.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68045181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioautography and FTIR Analysis of Ethanol Fraction Morel Berry Root (Physalis angulata L.) Against Staphylococcus epidermidis and Pseudomonas aeruginosa","authors":"Pratika Viogenta, Latifah Megasari, L. Susanti","doi":"10.22146/mot.78171","DOIUrl":"https://doi.org/10.22146/mot.78171","url":null,"abstract":"Morel berry root contains flavonoids, tannins, and alkaloids that have an antibacterial characteristics. This study aims to determine the antibacterial activity of the morel berry root ethanol fraction against Staphylococcus epidermidis and Pseudomonas aeruginosa and the most effective active compounds to inhibit such activity. Extractions of morel berry root used the maceration method with ethanol 70% of and then continued by fractionation using ethanol, chloroform, and n-hexane. Test of the compound fraction was performed using Thin Layer Chromatography (TLC) and characterization with FTIR Spectrophotometer. The results of the antibacterial activity with inhibitory zone diameter were at a 100% concentration of 18.69 mm in S. epidermidis while P. aeruginosa of 20.00 mm. Bioautographic results for ethanol fraction indicate an inhibited zone with an Rf value of 0.72 in the S. epidermidis and P. aeruginosa which is thought to be a flavonoid compound. Characterization with FTIR spectrophotometer functional groups O-H phenol, C = C aromatic, C-H aromatic, C-O alcohol, and C-H aliphatic in ethanol fraction with Rf 0.72.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49427466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Antioxidant Activity of Banana Peels, Pineapple Peels, and Combination Extracts of both Peels as Raw Materials in the Development of Hard Candy","authors":"P. Apridamayanti, Hadi Kurniawan, F. Nugraha, Inarah Fajriaty, S. Nurbaeti, L. Pratiwi","doi":"10.22146/mot.77474","DOIUrl":"https://doi.org/10.22146/mot.77474","url":null,"abstract":"Kepok banana and pineapple are horticultural commodities found in West Kalimantan. The two fruits are generally used as processed foods such as fried bananas and pineapple jam. The use of fruit as food often leaves the peel as a by-product, which can produce waste twice the weight of the food consumed. Meanwhile, waste utilization is an innovation in food processing into functional products which are developed into hard candy. Therefore, this research aims to the specific and non-specific characterization of raw materials for making candy, namely the combination of banana and pineapple peel extract (KP-KN). The characterization is organoleptic tests on the content of ethanol-soluble and water-soluble extracts. The Total phenolic content was determined by the Follin ciocalticeu method with UV/Vis spectrophotometry. Furthermore, antioxidant activity tests with DPPH and FRAP methods using UV/Vis spectrophotometry and ELISA to determine antioxidant activity. The mineral content was observed using the molybdate vandalate method with UV/vis spectrophotometry and ICP-MS, Heavy metal contamination using the ICP-MS tool, and microbial contamination using the plate method. Moreover, the infundation process was carried out on banana and pineapple peels, and the results were evaporated using a food dehydrator to obtain a combination extract. The results showed that the organoleptically KP-KN combination extract had a bitter taste, pineapple smells, 15.57% ash content, ethanol soluble extract content of 55.10%, and 47.99% water-soluble extract. Also, the total phenolic of 6.22 g/Kg, as well as the mineral content of Potassium (K), Calcium (Ca), Iron (Fe), Magnesium (Mg), Zinc (Zn), and Phosphorus (P), which were 47.23 g/Kg, 291.43 mg/Kg, <1x10-6 g/Kg, 2.59x10-3 g/Kg, and 2.38 g/Kg, respectively. Meanwhile, the heavy metal and bacterial contamination test showed that Arsenic (As), Sn, Mercury (Hg), and lead (Pb) were <1x10-6 g/Kg and Cadmium (Cd) was 0.0293. In the microbial contamination test with bacterial components including the ALT test, a value of 4.83 x 103 cfu/g was found, and there was no contamination from E.coli, mold, and yeast bacteria, DPPH and FRAP methods showed antioxidant activity combination extract banana peels and pineapple peels with values of 1390.96±2.83 mg/L and 4542.81±1.10 mg/L compare antioxidant activity of ascorbic acid as standard is 2.13 mg/L and 4.83 mg/L. The test with the KP-KN combined extract can be used as a raw material for making hard candy because it contains minerals needed by the body, meets the safety and quality requirements of traditional medicines, and has antioxidant activity in vitro.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45826633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Spermacoce radiata and Hypselodelphys poggeana Extract (CESH) Protect against Oxidative Stress and Enhances Haematological Parameters in Benign Prostatic Hyperplasia-induced Rats","authors":"Robert Ikechukwu Uroko, Favour Matthew Awah, Chinedu Aguwamba, M. Uche, Ikenna Obiwuru, Chinomso Friday Aaron, Ezichi Favour Ofoezie","doi":"10.22146/mot.76400","DOIUrl":"https://doi.org/10.22146/mot.76400","url":null,"abstract":"This study investigated the therapeutic effect of a combined extract of Spermacoce radiata and Hypselodelphys poggeana (CESH) on oxidative markers and haematological parameters in benign prostatic hyperplasia (BPH) induced rats. The study adopted five groups containing equal numbers of rats (n = 6), including normal control, BPH control, Finasteride control, BPH-induced rats treated with 200 mg/kg CESH, and BPH-induced rats treated with 600 mg/kg CESH. The rats were induced BPH by the subcutaneous administration of a 5 mg/kg testosterone propionate injection. At the same time, treatment finasteride and CESH to the respective groups were given orally 60 minutes after the BPH induction for 28 uninterrupted days. The induction of BPH with testosterone propionate injection caused a significant reduction in the serum levels of haematological parameters, including haemoglobin (Hb), packed cell volume (PCV), red blood cells (RBC), and platelet counts of the BPH control compared with normal control. The glutathione (GSH) concentration, glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase, and catalase activities decreased significantly in the BPH control relative to the normal control. The BPH control had elevated white blood cell (WBC), and malondialdehyde (MDA) concentrations contrary to the high WBC and MDA in the normal control and CESH treated BPH induced rats, respectively. Conversely, the Hb, PCV, platelet count, GPx, SOD, catalase, GST, and GSH increased significantly in the finasteride and CESH-treated BPH-induced rats, respectively, compared to the BPH control. These findings show that CESH attenuates adverse effects of BPH on antioxidant parameters and oxidative markers, which may prevent BPH progression.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45447551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical, GC-MS Analysis, and Antibacterial Activity of Ethanol Extract Coir and Shell U Groh (Cocos nucifera L.)","authors":"M. Misrahanum, nur alfiyani, H. Helwati, S. Sadli","doi":"10.22146/mot.75750","DOIUrl":"https://doi.org/10.22146/mot.75750","url":null,"abstract":"U Groh is a coconut (Cocos nucifera L.) in which the meat has not been formed yet, and its shell is consumed as a salad by the Acehnese people. This study aims to determine the phytochemicals, GC-MS analysis, and activity of coir and shell U Groh against S. aureus and E. coli bacteria. Chemical compounds were analyzed using reagents and GC-MS. Antibacterial activity was tested using well diffusion with concentrations of 5, 10, 20, and 40%. Coir and shells contain flavonoids, tannins, and saponins. GC-MS analysis shows the coir contains 20 compounds, among others Alpha. - Bisabololoxide B-Acetate, Hexadecanoic acid, Hexadecanoic acid methyl ester, 9 octadecenoic acid methyl ester, Stigmasterol, and gamma. -Sitosterol, whereas 16 compounds for the shell Hexadecanoic acid, Hexadecanoic acid methyl ester, and Stigmast-5-en-3-ol. The highest activity of coir and shell U Groh against E. coli and S. aureus was a concentration of 40%. The antibacterial activity of U Groh coir and shell extract was more effective in inhibiting S. aureus than E. coli. Coir ethanol extract and its shell formed inhibition zones with diameters of 13.7 mm and 13.4 mm, respectively, against S. aureus, and the diameters against E. coli were 11.3 mm and 11.03 mm, respectively. The extract ethanol of coir and shell U Groh has good potential as an antibacterial.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47486290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic and Antipyretic Effects of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract in White Male Rats","authors":"Betharia Lorenza Br Subakti, C. Ginting, L. Chiuman","doi":"10.22146/mot.76947","DOIUrl":"https://doi.org/10.22146/mot.76947","url":null,"abstract":"Red dragon fruit (Hylocereus polyrhizus) is a tropical fruit that is currently cultivated in all tropical parts of the world. It is popular to consume its fruit flesh, while the peel is often thrown away. This red dragon fruit peel (RDFPE) is known to possess lots of phytochemical compounds with multitudes of usage, amongst them as an analgesic and antipyretic. Therefore, the active compounds of RDFPE play an important role in the natural product. This study aims to observe and analyze the analgetic and antipyretic activity possessed by red dragon fruit peel. This study is an in-vivo experiment on 25 white male rats divided into five groups, in which each group receive Na CMC, acetaminophen, and the other three groups will receive three different doses of RDFPE (500 mg/kg, 750 mg/kg, and 1000 mg/kg), respectively. Acetic acid writhing and tail immersion methods were performed to induce inflammation and Brewer’s yeast injection performed induced pyrexia. In the investigation of the acetic acid writhing test, the intervention was administered before induction, and for the tail immersion test, induction was given before and after the intervention was administered. Meanwhile, in brewer’s yeast-induced pyrexia, the rectal temperature was measured before induction, 24 hours after induction, and each hour for five four after the intervention; intervention was administered 24 hours after induction. This study found that RDFPE at the dose of 750 mg/kg and 1000 mg/kg are effective as an analgesic by reducing the average writhing and delaying the tail retraction of the experiment subject and also effective as an antipyretic by reducing the elevated temperature of the experiment subject (p<0.05). This study concludes that RDFPE possesses analgesic and antipyretic activity, especially at the higher dose. Phytochemical compounds such as alkaloids and flavonoids are most likely responsible for this analgesic and antipyretic activity by inhibiting inflammation activity.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44698825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potency of Alpinia galanga as Natural Antioxidant","authors":"D. Laksmitawati, D. Pratami, W. Widowati, H. Kusuma, C. Wijayanti, R. Rizal","doi":"10.22146/mot.72450","DOIUrl":"https://doi.org/10.22146/mot.72450","url":null,"abstract":"An antioxidant is a chemical compound that can bind free radicals in the body. Reactive oxidative species (ROS) is a reaction that involves oxygen. ROS consists of free radicals and non-radical ones. The imbalance between ROS and antioxidants can cause oxidative stress, one of the factors contributing to the development of numerous diseases. This study aims to evaluate the possible antioxidant activity of lengkuas extract (LE), which may be employed as a medicine component to reduce ROS. The method that used in this research were total phenolic content, total flavonoid content, 2,2 diphenyl 1 picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), NO scavenging, 2,2′-Azinobis(3-Ethylbenzthiazoline-6-Sulfonate) (ABTS), and ferric reducing antioxidant power (FRAP). The result shows that the TPC of LE was 6.80 ± 0.34 (GAE) µg/mg with gallic acid standard and the TFC was 3.39 ± 0.06 µg/mg by quercetin standard. The IC50 value of LE were 121.20; 87.65; 139.94; 181.09 µg/ml by ABTS, DPPH, NO, and H2O2 assay respectively. The scavenging activity of LE was increased with a higher concentration in every method. In conclusion, Alpinia galanga has the potential as an antioxidant. Thus, it can be widely consumed or used as a mixture in medicine to reduce ROS.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48262236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The in-vitro Antioxidant Properties of Crude Drugs Traditionally Used for Diabetes Management in Northern Banyumas","authors":"D. Hartanti, Shintia Lintang Charisma, Widya Agustina, Rizky Destya Sary, Denia Awanda Putri, A. Hamad","doi":"10.22146/mot.76958","DOIUrl":"https://doi.org/10.22146/mot.76958","url":null,"abstract":"Chinaberry (Melia azedarach L.) leaves, Malayan cherry (Muntingia calabura L.) fruits, and Yacon (Smallanthus sonchifolius (Poepp.) H.Rob.) leaves are used for traditional diabetes treatment by Banyumas (Central Java, Indonesia) people. This study characterized selected quality parameters, evaluated the in-vitro antioxidant activity as the preliminary assay for its antidiabetic activity, and calculated the total flavonoid content (TFC) and total phenolic content (TPC) of those crude drugs. The plant materials of each species were collected from three different areas in Banyumas and dried into crude drugs. The quality parameters were determined according to the standard method in the Indonesian Herbal Pharmacopeia (IHP) 2017. The antioxidant activity was evaluated by the standard 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and ferric reducing antioxidant power (FRAP) assays, while TFC and TPC were analyzed following standard methods in IHP 2017. The correlations between antioxidant activities and the TFC-TPC were analyzed by Pearson's correlation test. The values for acid-insoluble ash, loss on drying, total ash, ethanol extractable, and water-extractable of all crude drugs were quantified, with TPC and TFC proposed as the chemical content parameter for Malayan cherry fruits and Yacon leaves. Yacon leaves and Malayan cherry fruits contained the highest TFC and TPC at 8.01±0.72 mg Quercetin equivalent (QE)/g dry weight (DW) and 11.54±1.44 mg Gallic acid equivalent (GAE)/g DW, respectively. Malayan cherry fruits exerted the strongest DPPH scavenging activity (366.13±17.65 mM Trolox equivalent (TE)/g DW) and FRAP (1025.33±50.47 mM TE/g DW). Moderate to strong correlations were observed between DPPH radical scavenging activity – FRAP and TFC-TPC of Malayan cherry fruits and Yacon leaves. Hence, flavonoids and phenolic compounds of both crude drugs contributed to their antioxidant activity.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48368154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Gelling Agent of Sunflower (Helianthus annuus) Seed Oil Gel and Its Stability and Activity Test In Vitro as Sunscreen","authors":"A. K. Zulkarnain, Feela Faridhotu, I. Pr","doi":"10.22146/mot.80299","DOIUrl":"https://doi.org/10.22146/mot.80299","url":null,"abstract":"Excessive ultraviolet (UV) radiation from the sun can harm human skin, such as skin erythema or sunburn, premature aging of the skin, darker skin discoloration, and damage to skin cells. Skin protection, like sunscreen, is needed to prevent the negative effects of UV rays. This study aims to evaluate the optimum formula, the physical properties, and the activity of a sunscreen gel preparation of sunflower seed oil in vitro. The method in this study was optimization with Design Expert version 10 of the carbopol gelling agent and sodium carboxymethyl cellulose. The optimum formula obtained was tested for its physical properties and activity as a sunscreen in vitro with a spectrophotometer.  The results showed that the physical properties of the optimum formula were good, and stable during storage, pH, spreadability, adhesion, and viscosity were close to predictions, and the in vitro SPF test obtained a value of 15.60.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48806720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Components Analysis of Bioactive Essential Oil Combinations (Lavender, Lemon, and Cinnamon) by Gas Chromatography-Mass Spectrometry and their Activities against In Vitro Photoaging on Hairless Rat Dorsal Skin","authors":"Hardi Astuti Witasari, K. Kintoko, Warsi Warsi, Salsabila Ramadhan, Nadiya Utari, Tsania Taskia Nabila","doi":"10.22146/mot.74197","DOIUrl":"https://doi.org/10.22146/mot.74197","url":null,"abstract":"The essential oil of lavender, lemon, and cinnamon (LaLC) combination is rich in antioxidants and potentially be used as an anti-wrinkle and strengthens the collagen tissue. Ultraviolet B (UVB) radiation is a free radical source that accelerates the aging process and reduces collagen production. This study aims to characterize the chemical components of each oil and determine the best combination as an anti-wrinkle substance. The test was conducted on twenty-four Wistar male rats (Mus musculus) that were divided into six experimental groups consisting of the normal (N), control (C), vehicle control (V), first treatment (T1), second treatment (T2), and third treatment (T3) groups. Each sample was rubbed upon, and the UVB irradiation was administered frequently to each subject. The embedded skin specimen was analyzed using a digital-capable microscope. Data were analyzed through the Kolmogorov-Smirnov normality test, one-way analysis of variance (ANOVA), and the post-hoc Tukey's Honest Significant Difference test. Lavender, lemon, and cinnamon essential oils contained each most significant component, which was linalool (41.46% peak area), dl limonene (44.74% peak area), and 2-propenal, 3-phenyl- (CAS) (53.89% peak area), respectively according to the Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The T1 showed the best score of all parameters and did not show significant significance compared to the N group. In conclusion, the 1:1:3 combination of LaLC is better in preventing in vitro photoaging than other treatment groups.","PeriodicalId":32438,"journal":{"name":"Majalah Obat Tradisional","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45969215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}