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Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference最新文献

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The friction-related component of a comprehensive slip-prediction model. I. Literature search for parametric inputs for ratiometric analysis 综合滑移预测模型中与摩擦有关的分量。1 .比率分析参数输入的文献检索
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514466
M. Marpet
To prevent slips, a comprehensive model for the prediction of slip would be useful. Such model must consider both qualitative and quantitative factors. Here, the author explores factors which can have a significant influence on pedestrian/walkway friction and, therefore, on slip probability. These factors will, in pt. II of this paper, be used as inputs to a set of ratiometrically-derived, dimensionless parameters which will characterize the friction-related component of a comprehensive slip-prediction model.
为了防止滑移,一个综合的滑移预测模型将是有用的。这种模型必须同时考虑定性和定量因素。在这里,作者探讨了可能对行人/人行道摩擦产生重大影响的因素,从而影响滑倒概率。在本文第2部分中,这些因素将被用作一组比率导出的无量纲参数的输入,这些参数将表征综合滑移预测模型中与摩擦有关的组成部分。
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引用次数: 2
A physical model of potential energy profiles of ions going through a biological membrane channel 离子通过生物膜通道的势能分布的物理模型
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514421
C. Zou, K. Cheng
To attempt to explain what determines a single particle (an ion or an ion group) penetration of a cell membrane channel, a physical model of potential energy profiles V/sub 2/(x) of a channel is proposed, based on the authors' previous study of one dimensional (1-D) steady state Schrodinger equation in a single particle system and in a time independent field. In this model, a V/sub 2/(x) is simplified as an effective constant height of potential energy barrier V/sub 2/ in a channel to obtain analytical solutions in mathematics. This model elucidates that: (1) Ion selectivity of a channel is determined by V/sub 2/. V/sub 2/ is divided into a V/sub 2c/ for a cation and V/sub 2a/ for an anion. V/sub 2c/ and V/sub 2a/ may be or may be not the same value depending on electrical characteristics of the particles and the channel. It is called a cation channel if a V/sub 2c/ is much lower than a V/sub 2a/ and vice versa. It is called a cation-anion cotransporter if a V/sub 2e/ and a V/sub 2a/ are equal or almost equal. (2) Whether a particle can penetrate through a channel is mostly determined by the repulsion energies (barriers) rather than the attraction energies (wells). (3) A channel's conformation can be changed when the channel is stimulated strongly enough. The variation of the conformation could influence V/sub 2/(x) and V/sub 2/, and eventually result in open or close of the channel.
为了解释是什么决定了单个粒子(离子或离子群)穿透细胞膜通道,基于作者先前在单粒子系统和时间无关场中的一维(1-D)稳态薛定谔方程的研究,提出了一个通道势能分布V/sub 2/(x)的物理模型。在该模型中,将V/sub 2/(x)简化为通道中有效的恒定高度势能垒V/sub 2/,从而得到数学上的解析解。该模型表明:(1)通道的离子选择性由V/sub /决定。V/sub 2/分为阳离子的V/sub 2c/和阴离子的V/sub 2a/。V/sub 2c/和V/sub 2a/可能是相同的值,也可能不是,这取决于粒子和通道的电特性。如果V/sub 2c/远低于V/sub 2a/,则称为阳离子通道,反之亦然。如果V/sub - 2e/和V/sub - 2a/相等或几乎相等,则称为正阴离子共转运体。(2)粒子能否穿透通道主要取决于斥力能(势垒)而非吸引能(阱)。(3)当通道受到足够强的刺激时,通道的构象会发生改变。构象的变化会影响V/sub - 2/(x)和V/sub - 2/,最终导致通道的开启或关闭。
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引用次数: 0
DNA transformation using electrically charged tungsten microelectrodes 利用带电钨微电极进行DNA转化
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514416
T. Harrington, E. Aamodt
DNA mediated genetic transformation has opened the door to molecular engineering of numerous species. Unfortunately, many other species have so far resisted transformation often because DNA cannot be moved into their germ cells by current methods. An alternate approach was sought where DNA is electrophoresed onto the tip of a tungsten microelectrode and the electrode inserted into the cell nucleus to effect transformation. This paper shows that DNA can be electrophoresed onto the tips of tungsten microelectrodes and that tungsten microelectrodes can be used to transform the germ line cells of the nematode C. elegans.
DNA介导的遗传转化为许多物种的分子工程打开了大门。不幸的是,到目前为止,许多其他物种一直抵制转化,通常是因为DNA无法通过现有方法转移到它们的生殖细胞中。另一种方法是将DNA电泳到钨微电极的尖端,并将电极插入细胞核以实现转化。本文证明了DNA可以电泳到钨微电极的尖端,钨微电极可以用来转化线虫的生殖系细胞。
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引用次数: 1
North Louisiana experience with bone and soft tissue malignancies 在北路易斯安那州经历过骨和软组织恶性肿瘤
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514480
J. J. Ward
Several major industries in rural North Louisiana are agriculture and forestry, with its associated paper mill factories. These industries utilize significant herbicides, such as dioxins. A Swedish study found a higher incidence of soft tissue sarcomas in patient populations exposed to these herbicides. The purpose of this retrospective study is to demonstrate a higher incidence of sarcomas in the rural areas of North Louisiana. Between 1988 and 1994, twelve patients with osteosarcoma were evaluated and treated. The twelve patients were from rural areas. Fourteen patients with soft tissue sarcoma were evaluated and treated between 1988 and 1994. Six patients were from the metropolitan area of Shreveport/Bossier City, and eight from the rural areas. For the osteosarcoma group, a two-fold increase in patients occurred in the rural areas. In the soft tissue sarcoma group, the overall incidence was lower for both areas, but more were seen from the rural area. This suggests that those patients from the rural areas of North Louisiana may have a higher risk of developing a sarcoma, and this trend may be related to herbicide exposure.
北路易斯安那州农村的几个主要产业是农业和林业,以及与之相关的造纸厂。这些工业使用重要的除草剂,如二恶英。瑞典的一项研究发现,在接触这些除草剂的患者群体中,软组织肉瘤的发病率更高。本回顾性研究的目的是证明在路易斯安那州北部的农村地区肉瘤发病率较高。在1988年至1994年间,我们对12例骨肉瘤患者进行了评估和治疗。这12名患者来自农村地区。在1988年至1994年间,对14例软组织肉瘤患者进行了评估和治疗。6例患者来自什里夫波特/博西尔市大都市区,8例来自农村地区。对于骨肉瘤组,农村地区的患者增加了两倍。在软组织肉瘤组中,两个区域的总体发病率都较低,但农村地区的发病率更高。这表明那些来自北路易斯安那州农村地区的患者可能有更高的患肉瘤的风险,这种趋势可能与除草剂接触有关。
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引用次数: 0
Potential hazards associated with photocuring dentin bonding agents 光固化牙本质粘接剂的潜在危害
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514445
N. Thompson, A. Puckett, S. Phillips, G. Reeves
Summary form only received as follows: Light sources used to cure dental restorative materials have improved greatly with many of them having intensities approaching 800 mW/cm/sup 2/. Because of the increased light intensity, the potential for exposing pulpal tissues to elevated temperatures is greater. The objective of this study was to measure the temperature rise associated with curing a dentin adhesive ProBond (Caulk Dentsply, Milford, DE) and a composite Z-100 (3M, St. Paul, MN) using an Optilux Model 401 light curing unit (Demetron Research Corp., Danbury, CT). The experimental set up consisted of a stainless steel mold having a diameter of 6 mm x 3 mm depth placed over a mylar strip and a type J thermocouple. The assembly was held at 37/spl deg/C. Three sets of measurements were taken in triplicate for the conditions: A) no material; B) bonding agent; C) bonding agent + 2 mm composite. Temperatures were recorded after exposure to the light for 10, 20, 30 and 40 seconds and are given in a table. The temperature increase was significant for each group. The largest temperature increase was 42.5/spl deg/C when no material was present. Placement of the bonding agent gave a maximum temperature increase of 31.6/spl deg/C while curing of the composite gave only a 9.5/spl deg/C increase due to its ability to act as an insulator. These results suggest that curing of bonding agents in deep restorations may expose the dentin surface to significant temperature increases even though the light source may be 3 mm from the exposed surface.
仅收到的摘要如下:用于修复牙齿修复材料的光源有了很大的改进,其中许多光源的强度接近800 mW/cm/sup /。由于光照强度的增加,使牙髓组织暴露在高温下的可能性更大。本研究的目的是测量牙本质粘合剂ProBond (Caulk Dentsply, Milford, DE)和复合材料Z-100 (3M, St. Paul, MN)使用Optilux Model 401光固化装置(Demetron Research Corp., Danbury, CT)固化时的温升。实验装置由一个直径为6毫米x 3毫米的不锈钢模具和一个J型热电偶组成。大会在摄氏37度的温度下举行。在以下条件下进行三组测量:A)无材料;B)粘结剂;C)粘结剂+ 2mm复合材料。在光下暴露10、20、30和40秒后记录温度,并以表格形式给出。各组体温升高均显著。无材料存在时,升温幅度最大,为42.5℃/spl℃。结合剂的放置使复合材料的温度最高升高了31.6/spl℃,而由于其作为绝缘体的能力,固化后的复合材料的温度仅升高了9.5/spl℃。这些结果表明,在深度修复体中,即使光源可能距离暴露表面3mm,固结剂的固化也会使牙本质表面暴露于显著的温度升高。
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引用次数: 0
Development of an athlete/shoe/surface-related injury prediction model for American football. 1. Systematic identification of qualitative and quantitative variables 橄榄球运动员/球鞋/表面损伤预测模型的建立。1. 系统地识别定性和定量变量
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514464
A. Fendley
This is pt. 1 of a two-part paper concerned with surface-related athletic injury prediction. The author considers the athlete, footwear, playing surface and interface factors as a system for assessment of injury prediction parameters. Based on a review of the literature, the author identifies and categorizes qualitative and quantitative factors in the athlete/shoe/surface/interface system important for injury prediction, using the sport of football as an example. The methodology should also be applicable to other sports.
这是关于表面相关运动损伤预测的两部分论文的第一部分。笔者将运动员、球鞋、场地和界面因素作为损伤预测参数的评价体系。在回顾文献的基础上,作者以足球运动为例,对运动员/鞋/表面/界面系统中对损伤预测重要的定性和定量因素进行了识别和分类。该方法也应适用于其他体育项目。
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引用次数: 2
A hydroxyapatite ceramic matrix device for continuous delivery of coumadin 香豆素连续输送用羟基磷灰石陶瓷基质装置
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514452
K. Leuenberger, I. Mileti, R. Singh, P. K. Bajpai
Coumadin is one of the most widely used oral anticoagulants for preventing several types of thromboembolic complications. However, coumadin, when given in dosages which maintain the plasma levels slightly above the effective threshold, has been associated with severe side effects such as excessive hemorrhaging and necrosis. Development of an implantable, biodegradable hydroxyapatite ceramic device for continuous delivery of effective amounts of coumadin should alleviate these side effects. The ceramic devices used in this experiment consisted of 400 mg HA and 100 mg coumadin compressed at loads of 3000, 6000, and 9000 lbs. in a hydraulic press. The ceramic devices released their entire anticoagulant content within 12 hours, with a linear release for the first four hours. Ceramics compressed at different loads released significantly different amounts of coumadin for the first four hours of the experiment. Since the amounts of drug released in one day in vitro are released for almost 10 to 15 days in vivo, the data obtained in this study suggest that hydroxyapatite ceramic matrix implants containing 100 mg coumadin should release the anticoagulant continuously for a minimum of 10 days in vivo.
香豆素是最广泛使用的口服抗凝剂之一,用于预防几种类型的血栓栓塞并发症。然而,当香豆素的剂量维持血浆水平略高于有效阈值时,会产生严重的副作用,如过度出血和坏死。开发一种可植入的、可生物降解的羟基磷灰石陶瓷装置,用于持续递送有效量的香豆素,应该可以减轻这些副作用。本实验中使用的陶瓷装置由400毫克HA和100毫克香豆素组成,分别在3000、6000和9000磅的载荷下压缩。在液压机里。陶瓷装置在12小时内释放出全部抗凝血成分,前4小时呈线性释放。在实验的前四个小时,在不同载荷下压缩的陶瓷释放的香豆素量明显不同。由于在体外一天释放的药物量在体内几乎可以释放10 - 15天,因此本研究的数据表明,含有100mg香豆素的羟基磷灰石陶瓷基质植入物在体内至少可以连续释放10天的抗凝血剂。
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引用次数: 1
Tissue engineering with the use of polymers 使用聚合物的组织工程
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514461
Y. Ikada
Summary form only received. The author presents some results by obtained by collaborative work with medical people on tissue engineering using resorbable polymers such as polylactides and collagen. The tissues studied for regeneration include bones, skin, ligaments, and fibrous cartilage. The fixation of fractured bones in joints, jaw, and the face was performed using screws, pins, and mini-plates prepared from a high-strength poly(L-lactide). Regeneration of lost mandibula with the help of a poly(L-lactide) tray containing the patient's cancellous bone is currently undergoing clinical trials. A bilayered artificial skin was fabricated from a thin silicone sheet and a thick porous collagen sheet without glycosaminoglycans. The artificial skin functioned very effectively as the scaffold for the regeneration of the dermis tissue of full skin-deficient patients. The epidermis graft of patient origin was covered on the regenerated dermis to enable regeneration of the whole skin. Regeneration of broken anterior cruciate ligaments was attempted with the use of poly(L-lactide) fibers. The results with goats and sheep were as good as those of a non-resorbable ligament assist device. The periodontic ligament also could be regenerated with the use of a glycolide-lactide copolymer membrane.
只收到摘要表格。作者介绍了利用聚乳酸和胶原蛋白等可吸收聚合物进行组织工程的一些成果。研究再生的组织包括骨骼、皮肤、韧带和纤维软骨。使用高强度聚l -丙交酯制备的螺钉、销钉和微型钢板固定关节、下颌和面部骨折骨。用含有患者松质骨的聚l -丙交酯托盘再生失去的下颌骨目前正在进行临床试验。用不含糖胺聚糖的薄硅胶片和厚多孔胶原片制备了双层人工皮肤。该人造皮肤作为支架在全皮肤缺损患者真皮组织再生中发挥了非常有效的作用。患者的表皮移植物覆盖在再生的真皮层上,使整个皮肤再生。尝试使用聚l -丙交酯纤维再生断裂的前交叉韧带。山羊和绵羊的结果与非可吸收韧带辅助装置一样好。牙周韧带也可以用乙醇-丙交酯共聚物膜再生。
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引用次数: 0
Evaluation of unalloyed titanium implant surfaces 非合金钛种植体表面的评价
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514434
D. Kilpadi, G. N. Raikar, R. Connatser, J. Liu, J. Lemons, J. Gregory, Y. Vohra
The effects of surface treatment procedures as recommended by the American Society for Testing and Materials on the surface of unalloyed titanium implants were examined. Solid surface tension assessment suggested that the two-liquid Zisman plots were not sensitive to polar components and resulted in trends different from the two-liquid Kaelble plots. Raman studies did not show any crystalline order and X-ray photoelectron spectroscopy results indicated that the surface layers were composed primarily of a TiO/sub 2/ type stoichiometry along with 3 hydrocarbon overlayer. The surfaces also contained varying, although minute, amounts of surface contamination.
研究了美国材料与测试学会推荐的非合金钛植入体表面处理程序的效果。固体表面张力评价表明,两液Zisman图对极性分量不敏感,其变化趋势与两液Kaelble图不同。拉曼光谱没有显示出任何晶体秩序,x射线光电子能谱结果表明,表层主要由TiO/ sub2 /型化学计量组成,并有3个碳氢化合物覆盖层。这些表面也含有不同数量的表面污染,尽管数量很小。
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引用次数: 1
Textile composite wound dressing 纺织复合敷料
Pub Date : 1995-04-07 DOI: 10.1109/SBEC.1995.514414
A. London, A. Tonelli, S. Hudson, B. Gupta, K.B. Wylie, G. Spodnick, B. Sheldon
Poly lactic acid (PLA), poly /spl epsiv/-caprolactone (PCL), and chitosan (CH) are incorporated into a biodegradable wound dressing. Physical properties of these films, including topography, water vapor permeability, degradation, and bacterial permeation as well as biological effects of toxicity on human fibroblast cells were studied. An in vivo study currently in progress is proposed.
聚乳酸(PLA)、聚/己内酯(PCL)和壳聚糖(CH)被掺入到一种可生物降解的伤口敷料中。研究了这些膜的物理性质,包括形貌、水蒸气渗透性、降解性、细菌渗透性以及对人成纤维细胞毒性的生物学效应。提出了一项正在进行的体内研究。
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引用次数: 4
期刊
Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference
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