Objective
Polysaccharides, as natural bioactive macromolecules with anti-tumor potential, have become a research hotspot in the context of limited traditional cancer treatment methods. However, there is a lack of systematic reviews and clear delineation of future trends in this field regarding polysaccharide-based anti-tumor therapy. To fill this gap, this study aims to analyze the research hotspots and trends using bibliometric methods, providing support for promoting clinical translation.
Method
Relevant literature was retrieved from the Web of Science database, and key indicators such as annual publication volume, national/institutional collaboration models, and research hotspots were visually analyzed.
Result
The global publications on polysaccharide-based anti-tumor therapy have been on the rise. China, the United States, and India are the top three countries in terms of output. The research hotspots can be clustered into three major directions: “Polysaccharide-based nanocarriers and tumor-targeted delivery”, “Polysaccharide-mediated drug delivery systems and efficacy enhancement”, and “Polysaccharide anti-tumor mechanisms and tumor treatment effects”. Current research focuses on nanocarrier construction, targeted delivery mechanisms, and exploration of the anti-tumor activity of natural polysaccharides.
Conclusion
Research on polysaccharide-based anti-tumor therapy is steadily developing and has a cross-disciplinary characteristic. Based on the analysis of the research dynamics in this field, this study not only further validates and highlights the anti-tumor potential of polysaccharides, but also clearly indicates that future research will focus on precision medicine, combined treatment, and green synthesis technologies, providing key references for promoting clinical innovation and transformation in tumor treatment.
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