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Melanin nanoparticles scavenging reactive oxygen and nitrogen radicals for rheumatoid arthritis treatment 清除活性氧和氮自由基的黑色素纳米粒子用于类风湿性关节炎的治疗
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240921
Zekun Lang
Rheumatoid arthritis (RA) is a complex and chronic disease that often causes long-term pain and joint swelling in patients, and even causes joint deformity and dysfunction. The pathogenesis of this disease involves abnormal activity of the immune system, causing immune cells to attack the bodys joint tissues, which triggers an inflammatory response. During these inflammatory processes, the accumulation of reactive oxygen and nitrogen species (RONS) is considered to be one of the key factors that aggravate inflammation and damage joint tissues. To address this problem, we designed a method that takes advantage of the targeting properties of melanin nanoparticles. These nanoparticles have excellent biocompatibility, can remain stable in the body, and can be accurately targeted to the site of inflammation. In addition, these nanoparticles also have strong free radical scavenging ability, which can effectively neutralize excessive RONS, reduce the inflammatory response and weaken joint tissue damage. The promise of this treatment strategy is encouraging and offers new hope for patients with RA. By reducing inflammation, protecting joint tissue, and possibly even reversing the disease process to some extent, this melanin nanoparticle holds great promise.
类风湿性关节炎(RA)是一种复杂的慢性疾病,通常会导致患者长期疼痛和关节肿胀,甚至造成关节畸形和功能障碍。这种疾病的发病机制是免疫系统活动异常,导致免疫细胞攻击人体关节组织,从而引发炎症反应。在这些炎症过程中,活性氧和氮物种(RONS)的积累被认为是加重炎症和破坏关节组织的关键因素之一。为解决这一问题,我们设计了一种利用黑色素纳米粒子靶向特性的方法。这些纳米粒子具有良好的生物相容性,能在体内保持稳定,并能准确地靶向炎症部位。此外,这些纳米粒子还具有很强的自由基清除能力,能有效中和过量的 RONS,减轻炎症反应,削弱关节组织损伤。这种治疗策略的前景令人鼓舞,为关节炎患者带来了新的希望。通过减轻炎症、保护关节组织,甚至可能在一定程度上逆转疾病进程,这种黑色素纳米粒子前景广阔。
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引用次数: 0
Research on the analysis and management measures of land subsidence caused by groundwater exploitation in Tianjin, China 中国天津地下水开采引起的地面沉降分析及治理措施研究
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240924
Yuxin Sun
Since the 20th century, there has been an increasing reliance on groundwater due to the rapid development of agriculture and industry. This has resulted in the exploitation of groundwater in large quantities, leading to global land subsidence problems. Tianjin is one of the cities where this problem first emerged, but few studies and surveys have been conducted. As a result, the lack of management of groundwater extraction has caused the issue of land subsidence to become more prominent in recent years. By investigating and collating global research on land subsidence problems caused by groundwater extraction, it is concluded that mathematical and numerical methods, global information systems, remote sensing, and other technologies can be utilized to monitor and predict groundwater levels. Regional management measures can then be developed based on simulation results. However, the application of such technology in Tianjin is insufficient, and there is a need to strengthen the connection between management measures and research data analysis results.
自 20 世纪以来,由于农业和工业的快速发展,人们对地下水的依赖越来越大。这导致了地下水的大量开采,引发了全球性的土地沉降问题。天津是最早出现这一问题的城市之一,但相关研究和调查却很少。因此,由于缺乏对地下水开采的管理,近年来土地塌陷问题日益突出。通过调查和整理全球对地下水开采造成的地面沉降问题的研究,得出结论认为,可以利用数学和数值方法、全球信息系统、遥感和其他技术来监测和预测地下水位。然后可以根据模拟结果制定区域管理措施。然而,这些技术在天津的应用还不够充分,需要加强管理措施与研究数据分析结果之间的联系。
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引用次数: 0
A review of EDLC and pseudocapacitance with synergistic integration of carbon-based and metal oxide materials for enhanced electrochemical energy storage 碳基材料与金属氧化物材料协同集成用于增强电化学储能的 EDLC 和伪电容综述
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240968
Honghan Li
This paper provides a comprehensive analysis of the recent advancements in electrochemical double-layer capacitors (EDLCs) and pseudocapacitance, emphasizing the pivotal role of carbon-based materials, metal oxides, conducting polymers, and composites in augmenting the energy storage landscape. Through a systematic collection of electrochemical performance metrics, we elucidate the inherent advantages of these materials, such as superior electrical conductivity, enhanced surface area, and chemical robustness, which are instrumental in the development of next-generation supercapacitors. We discuss the integration of novel materials like reduced graphene oxide/hexagonal boron nitride composites, carbon onions, and various metal oxides that contribute to a significant increase in energy density and cycling stability. This work also highlights innovative fabrication techniques and synthesis methodologies that have resulted in electrodes with remarkable performance enhancements. Furthermore, the exploration of synergistic effects between different materials has led to hybrid structures that exhibit improved capacitive properties and operational efficiency.
本文全面分析了电化学双层电容器(EDLC)和伪电容的最新进展,强调了碳基材料、金属氧化物、导电聚合物和复合材料在增强能量存储领域的关键作用。通过系统收集电化学性能指标,我们阐明了这些材料的固有优势,如卓越的导电性、增强的比表面积和化学稳健性,这对开发下一代超级电容器至关重要。我们讨论了还原氧化石墨烯/六方氮化硼复合材料、碳葱和各种金属氧化物等新型材料的整合,这些材料有助于显著提高能量密度和循环稳定性。这项工作还重点介绍了创新的制造技术和合成方法,这些技术和方法使电极的性能显著提高。此外,通过对不同材料之间协同效应的探索,混合结构的电容特性和运行效率也得到了改善。
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引用次数: 0
Monitoring of urban expansion in Burlington based on remote sensing data 利用遥感数据监测伯灵顿城市扩张情况
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240926
Hao Li
Burlington VT has been expanding in the last few decades due to new immigrants moving into the area for opportunities. Accurate and comprehensive data on the landscape, vegetation coverage, and human activities are essential for knowing the current status of the city and its surrounding environment and for planning the future city expansion by the government. The current study employed remote sensing as the currently most advanced method to measure and monitor the landscape changes and urban expansion of the Burlington area between 2015 and 2023. The results from the remote sensing clearly showed that the lake shape changed, the wasteland areas decreased and the human activities expanded in the Burlington area between the year 2015 and the current year. These clear trends supported by the satellite images and the potential correlation between these trends provide valuable information for city regulators to decide how the city should be expanded, how the environment should be protected, and what issues need to be addressed in the future.
在过去的几十年里,由于新移民涌入该地区寻找机会,弗吉尼亚州伯灵顿市的面积不断扩大。准确全面的景观、植被覆盖和人类活动数据对于了解城市及其周边环境的现状以及政府规划未来的城市扩张至关重要。本次研究采用了遥感这一目前最先进的方法来测量和监测伯灵顿地区在 2015 至 2023 年间的景观变化和城市扩张情况。遥感结果清楚地表明,从 2015 年到今年,伯灵顿地区的湖泊形状发生了变化,荒地面积减少,人类活动扩大。卫星图像支持的这些明显趋势以及这些趋势之间的潜在关联为城市管理者提供了宝贵的信息,帮助他们决定城市应如何扩张、环境应如何保护以及未来需要解决哪些问题。
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引用次数: 0
Seismic resistance analysis of a plywood house structure based on ABAQUS fracture mechanics 基于 ABAQUS 断裂力学的胶合板房屋结构抗震分析
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240955
Nian Li
Plywood is a more affordable material for the residential construction industry due to its lower cost and easy availability. However, earthquakes are the biggest barrier for wood structures to stand for a long time, as the materials can easily deform or collapse when subjected to seismic forces. This paper aims to explore the performance of plywood structures during an active earthquake by conducting a series of tests and simulations. In this study, plywood property was explored in the four-point bending experiment to determine its stress-strain relationship, and the results were used to identify the materials young modulus, a key parameter for designing more resilient structures. In addition, a finite element model of a plywood house structure was developed in the ABAQUS application, and the seismic movements with five different velocity values were applied to determine the stress distribution and deflections of the structure. The results provide insights into the dynamic behavior of plywood structures under different seismic movements.
胶合板因其成本较低且易于获得,是住宅建筑业较为经济实惠的材料。然而,地震是木质结构长期屹立不倒的最大障碍,因为这种材料在受到地震力作用时很容易变形或倒塌。本文旨在通过进行一系列测试和模拟,探讨胶合板结构在活动地震中的性能。在这项研究中,通过四点弯曲实验探索了胶合板的特性,以确定其应力-应变关系,并利用结果确定了材料的年轻模量,这是设计更具弹性结构的关键参数。此外,还在 ABAQUS 应用程序中建立了胶合板房屋结构的有限元模型,并应用五种不同速度值的地震运动来确定结构的应力分布和挠度。研究结果为胶合板结构在不同地震运动下的动态行为提供了启示。
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引用次数: 0
The influence of the application of glass curtain walls on architectural style and architectural facade design techniques 玻璃幕墙的应用对建筑风格和建筑立面设计技术的影响
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240984
Zhibei Mu
In recent years, with the increasingly rapid development of the glass curtain wall and its gradually mature use in architecture, many designers choose to use glass curtain walls when designing buildings in order to get the desired building facade effect. As a result, there are many new architectural styles and building facade effects. Against this background, this paper discusses how glass curtain wall is applied in architecture and how it helps and influences architectural design styles and techniques. To conclude, the glass curtain wall has been widely used in the design of high-rise buildings and public buildings at this stage, and it also helps designers to more conveniently adjust the virtual-real relationship of building facades and the overall architectural style. The use of large-area glass curtain walls in the design of facades can achieve special effects that cannot be replaced by other materials. At the same time, the application of glass facades also promotes the process of architectural design modernization.
近年来,随着玻璃幕墙的发展日益迅速,在建筑中的应用也逐渐成熟,许多设计师在设计建筑时都会选择使用玻璃幕墙,以获得理想的建筑立面效果。因此,出现了许多新的建筑风格和建筑立面效果。在此背景下,本文探讨了玻璃幕墙在建筑中的应用,以及它对建筑设计风格和技术的帮助和影响。总之,玻璃幕墙在现阶段的高层建筑和公共建筑设计中得到了广泛的应用,也帮助设计师更方便地调整建筑立面的虚实关系和整体建筑风格。在外立面设计中使用大面积玻璃幕墙,可以达到其他材料无法替代的特殊效果。同时,玻璃幕墙的应用也推动了建筑设计现代化的进程。
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引用次数: 0
La Nia and climate degree of contact 拉尼娅与气候的接触程度
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240953
Yu XinYe
Studies have shown that the 2022 anomalous climate change is different from previous La Nia phenomena. Using the data of the maximum temperature, minimum temperature and temperature difference from 2020 to March 2021 in Hong Kong, the grey model was used to compare the maximum and minimum temperature values in 2022 with the actual values and found that the values were close. The La Nia phenomenon occurred in March 2022, concluding that La Nia is not a major contributor to climate change in Hong Kong. Climate change in Hong Kong is also linked to typhoons, increased carbon dioxide levels in the air, ocean temperatures and other factors. The study concluded that the main cause of the extreme weather in Hong Kong in 2022 was not the occurrence of La Nia, but a combination of factors such as cumulative carbon dioxide emissions, human activities, the altitude of the Tibetan Plateau, and typhoons.
研究显示,2022 年的异常气候变化与以往的拉尼娅现象不同。利用香港 2020 年至 2021 年 3 月的最高气温、最低气温和温差数据,使用灰色模型将 2022 年的最高气温和最低气温值与实际值进行比较,发现两者值接近。拉尼娅现象发生在 2022 年 3 月,结论是拉尼娅并不是造成香港气候变化的主要因素。香港的气候变化还与台风、空气中二氧化碳含量增加、海洋温度和其他因素有关。该研究得出结论,2022 年香港极端天气的主要原因不是 "拉尼娅 "的出现,而是二氧化碳累积排放、人类活动、青藏高原海拔高度和台风等因素的综合作用。
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引用次数: 0
Study on biomimetic superhydrophobic mechanisms and existing issues 研究生物仿生超疏水机理和现有问题
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240942
Yijing Qiu
The realm of biomimetic superhydrophobic surfaces encompasses a diverse range of applications, yet the specific biomimetic mechanisms, theories, models, and preparation methods remain shrouded in ambiguity. To address this gap, a meticulous examination of the current theories and preparation methods is imperative for guiding further biomimetic superhydrophobic research. This study, adopting a dual perspective from superhydrophobic theory and the intricate interplay between droplets and surfaces, intricately synthesizes the relevant theories and models pertaining to biomimetic superhydrophobic microstructures. Delving into the existing challenges in theoretical research and preparation methods within the field of biomimetic superhydrophobics, the research not only identifies current limitations but also lays the groundwork for future explorations. This systematic inquiry contributes not only to a nuanced understanding of existing biomimetic superhydrophobic surfaces but also provides a robust foundation for future studies and technological innovations. As the research unfolds, it propels the scientific community towards a more comprehensive grasp of biomimetic superhydrophobic phenomena, promising advancements, and applications across various scientific and technological domains.
生物仿生超疏水表面的应用领域多种多样,但具体的生物仿生机制、理论、模型和制备方法仍然模糊不清。为了弥补这一缺陷,必须对当前的理论和制备方法进行细致的研究,以指导进一步的生物仿生超疏水研究。本研究从超疏水理论和液滴与表面之间错综复杂的相互作用的双重视角出发,对生物仿生超疏水微结构的相关理论和模型进行了复杂的综合。该研究深入探讨了仿生超疏水性理论研究和制备方法领域的现有挑战,不仅指出了当前的局限性,还为未来的探索奠定了基础。这项系统性研究不仅有助于深入了解现有的仿生物超疏水表面,还为未来的研究和技术创新奠定了坚实的基础。随着研究的展开,它将推动科学界更全面地掌握生物仿生超疏水现象、有望取得的进展以及在各个科学和技术领域的应用。
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引用次数: 0
Characteristics and properties of anode materials for lithium-ion batteries 锂离子电池负极材料的特性和性能
Pub Date : 2024-05-08 DOI: 10.54254/2755-2721/61/20240937
Xinghao Lu
Lithium-ion secondary batteries (LIBs) are battery systems with high energy densities. They are essential components of todays information-rich, mobile societys portable, entertainment, computing, and telecommunications technology. After 1981, most of the research on anode materials mainly focused on the anode containing Li, such as LiAl alloy, LiC alloy, etc. These materials have high prices, unstable cycling performance, and are difficult to be commercialized. The successful commercialization of LIBs began in 1991 with SONYs manufacturing of petroleum coke-based anode materials. Among them, anode plays a crucial role in LIBs. Anode materials that have been commercialized include carbon, alloys, and lithium titanate. Lithium-ion batteries using carbon anode materials and lithium titanate anode materials can meet the needs of electric vehicles (EVs) and large-scale energy storage applications to a certain extent, and alloy anode materials can promote the energy density of LIBs. The properties of the commercialized anode materials are covered in this paper. Next generation anode materials such as silicon anode materials are also introduced.
锂离子二次电池 (LIB) 是一种高能量密度的电池系统。它们是当今信息丰富的移动社会便携、娱乐、计算和电信技术的重要组成部分。1981 年以后,大多数负极材料研究主要集中在含锂负极上,如 LiAl 合金、LiC 合金等。这些材料价格高、循环性能不稳定,难以实现商业化。LIB 的成功商业化始于 1991 年 SONY 公司生产的石油焦基阳极材料。其中,阳极在 LIB 中起着至关重要的作用。已实现商业化的负极材料包括碳、合金和钛酸锂。使用碳负极材料和钛酸锂负极材料的锂离子电池可以在一定程度上满足电动汽车(EV)和大规模储能应用的需求,而合金负极材料则可以提高锂离子电池的能量密度。本文介绍了商业化阳极材料的特性。本文还介绍了下一代阳极材料,如硅阳极材料。
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引用次数: 0
Fluid dynamics study on flight performance improvement of morphing winglets on jetliners 关于喷气式客机变形小翼飞行性能改进的流体动力学研究
Pub Date : 2024-05-07 DOI: 10.54254/2755-2721/59/20240802
Jingxi Xia
Winglets are structures with unique shapes designed on the wingtips of aircraft. They were first time justified as a device that can improve aircraft fuel efficiency by generating more lift in the last century and have been widely used in the aviation industry until today. The current winglets installed on jetliners, however, are fixed, resulting in that winglets can only be aerodynamically optimized for single flight condition. Searching for further improvement on flight performance, this paper investigates and analyzes two types of morphing winglets that can adjust their configurations during flight for aerodynamic optimizations under multiple conditions. Three computational studies based on three current business jets, representing aerodynamic characteristics of typical jetliners, are referenced. The studies results are presented and categorized into different flight phases, and the flight performance is embodied in terms of aircraft maximum climb rate, lift-to-drag ratio, and cruise fuel flow rate. Finally, the overall performance gained and the feasibility of implementation are evaluated.
小翼是飞机翼尖上设计的具有独特形状的结构。上个世纪,这种结构首次被证明可以通过产生更大的升力来提高飞机的燃油效率,并在航空业广泛应用至今。然而,目前安装在喷气式客机上的小翼是固定的,导致小翼只能在单一飞行条件下进行空气动力学优化。为了进一步提高飞行性能,本文研究和分析了两种可在飞行过程中调整配置的变形小翼,以便在多种条件下进行气动优化。本文参考了三项基于当前三架公务喷气机的计算研究,代表了典型喷气式客机的气动特性。研究结果按不同的飞行阶段进行了展示和分类,并从飞机最大爬升率、升阻比和巡航燃油流量等方面体现了飞行性能。最后,对获得的总体性能和实施的可行性进行了评估。
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引用次数: 0
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Applied and Computational Engineering
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