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Psychological and behavioral symptoms in Alzheimer's disease: Impact on professional caregivers burden and non-pharmacological management strategies 阿尔茨海默病的心理和行为症状:对专业护理人员负担的影响和非药物管理策略
Q4 Medicine Pub Date : 2025-07-17 DOI: 10.1016/j.npg.2025.06.002
Aline Muhigwa, Sandrine Kalenzaga
Alzheimer's disease (AD) is a common degenerative disease characterized by chronic cognitive impairment. Apart from cognitive impairments, psychological and behavioral symptoms of Alzheimer's disease (PBSAD), also known as neuropsychiatric symptoms, are crucial components responsible for morbidity, which can directly affect the quality of life of both patients and professional caregivers. Symptoms such as agitation, depression, anxiety, aggression, apathy, and delusions are common at every stage of AD and may escalate as the disease progresses. While considerable research has been devoted to understanding the impact of PBSAD on family caregivers, there has been less examination of the experiences of professional caregivers. We reviewed the classification and structure of PBSAD, the effects on professional caregiver burden, and the strain caused by the most difficult symptoms on healthcare personnel. Tools like the Neuropsychiatric Inventory (NPI) and various burden assessment scales, including the Zarit Burden Interview, have been utilized to evaluate how often these symptoms occur and their severity, and their effects on caregivers. Agitation and aggression were reported as particularly challenging. This review also describes non-pharmacologic strategies to address PBSAD and reduce formal caregiver burden. Since PBS vary widely in both type and intensity, specific training and supportive networks are required to ensure that health care providers have the tools they need to address these symptoms. A better understanding of the relationship between PBSAD and professional caregiver burden will enable strategies to designed to optimize patient care and foster the wellness of both professional caregivers and the patients themselves.
La maladie d’Alzheimer (MA) est une pathologie neurogénérative fréquente, caractérisée par une détérioration progressive des capacités cognitives. Toutefois, en plus des troubles cognitifs, les manifestations comportementales et psychologiques, connues également sous le nom de symptômes neuropsychiatriques, influencent de manière significative la qualité de vie des patients, de leur entourage et des professionnels soignants. Ces manifestations regroupent des éléments tels que l’agitation, la dépression, l’anxiété, l’agressivité, l’apathie et les délires, apparaissant à tous les stades de la MA. Bien qu’un grand nombre de recherches se soient penchées sur l’impact symptômes psychologiques et comportementaux sur les proches aidants, il existe peu d’études ayant évalué leur impact sur les soignants prenant en charge les patients Alzheimer. La présente revue a pour objectif d’examiner les effets des symptômes psychologiques et comportementaux liés à la maladie d’Alzheimer (SPCMA) sur les soignants professionnels, en particulier dans le contexte français, pour lequel la littérature est rare, avec seulement deux études sur le sujet. Ces études se concentrent sur l’anosognosie et son association au
阿尔茨海默病(AD)是一种以慢性认知障碍为特征的常见退行性疾病。除了认知障碍外,阿尔茨海默病的心理和行为症状(PBSAD),也称为神经精神症状,是导致发病率的关键因素,可直接影响患者和专业护理人员的生活质量。躁动、抑郁、焦虑、攻击、冷漠和妄想等症状在阿尔茨海默病的每个阶段都很常见,并可能随着疾病的进展而升级。虽然有相当多的研究致力于了解PBSAD对家庭照顾者的影响,但对专业照顾者经验的研究却很少。我们回顾了PBSAD的分类和结构,对专业护理人员负担的影响,以及由最困难的症状对医护人员造成的压力。神经精神病量表(NPI)和各种负担评估量表(包括Zarit负担访谈)等工具已被用于评估这些症状发生的频率和严重程度,以及它们对护理者的影响。据报道,躁动和攻击性尤其具有挑战性。本综述还描述了解决PBSAD和减轻正式照顾者负担的非药物策略。由于公共卫生服务的类型和强度差别很大,因此需要专门的培训和支持网络,以确保卫生保健提供者拥有处理这些症状所需的工具。更好地理解PBSAD与专业护理人员负担之间的关系,将有助于制定优化患者护理的策略,并促进专业护理人员和患者自身的健康。阿尔茨海默病(MA)是一种病理:神经型、神经型、人格型、人格型、人格型、渐进式、能力型、认知型。Toutefois, en + des麻烦认知,les表现,comcomementales和psychologiques,连续的抑郁,连续的抑郁,神经精神病学,影响,显著的生活质量,患者生活质量,工作人员生活质量。这些表现分别代表了“激动”、“压抑”、“焦虑”、“激进”、“沮丧”、“沮丧”、“沮丧”、“沮丧”、“沮丧”、“沮丧”和“沮丧”。瞿好一个大数量生物se的数字penchees苏尔的症状psychologiques et comportementaux苏尔les接近帮助的,它存在一些研究ayant安勤科技为了影响苏尔les soignants她以前在les老年痴呆症患者。洛杉矶现在的revue倒目的d 'examiner les运用des症状psychologiques et comportementaux谎言La病d 'Alzheimer (SPCMA)苏尔les soignants来完成,en particulier在contexte法语,倒lequel litterature是罕见的,用seulement两个练习曲在我。这些病例集中于疾病感病,与疾病感病相关的疾病感病,以及与疾病感病相关的重要事件symptômes。这两种表现分别为:<s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> <s:1> - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -L 'impact de ces symptômes sur le fardeau des soignants est est samement (zit Burden Interview)、L ' Index de pression sur le proche aidant (Caregiver Strain Index [CSI])、qui samvalue le stress哀伤哀伤、体质与社交哀伤。特别纲领,特别是“激越”和“激进”的纲领,是一种努力的象征。这些表现会导致压力的增加,如抑郁和抑郁,持续的疲劳会增加,如焦虑和抑郁,以及对身体的祝福。D ' auterres的表现表明,抑郁和抑郁对患者的抑郁情绪有显著影响,抑郁和抑郁对患者的抑郁情绪有显著影响,抑郁和抑郁对患者的抑郁情绪有显著影响,抑郁和抑郁对患者的抑郁情绪有显著影响。这句的意思是:“我认为,如果你认为你是一个成功的人,你就会认为你是一个成功的人。”没有足够的时间来证明自己是成功的,也没有足够的时间来证明自己是成功的。我们将主要讨论下列问题:1 .在形成过程中:1 .在形成过程中:1 .在形成过程中:1 .在形成过程中:1 .在形成过程中:1 .在形成过程中:1 .在形成过程中:干预措施的实施办法、非<s:1> <s:2> <s:2> <s:2> <s:2>的<s:2> <s:2>的<s:2> <s:2>的······Étant donnise ' efficitrestreest et l 'ampleur ' efficitrestreest et l 'ampleur ' efficitresest est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est est
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引用次数: 0
Deciphering the molecular and neuropathological dimensions of dementia 解读痴呆的分子和神经病理维度
Q4 Medicine Pub Date : 2025-07-10 DOI: 10.1016/j.npg.2025.05.002
Sumit Dutta , Piyush Bhattacharjee , Shaheen Noori , Nilanjan Adhikari , Samar Dule , Mir Irfan Soyel , Malay Besra , Sudarshana Borah , Priyanka Gupta

Introduction

Dementia covers a complex spectrum of cognitive disorders characterized by various pathological mechanisms, significantly impacting individuals and society. Currently, over 55 million people are affected worldwide with the economic burden predicted to increase from $2.8 trillion in 2019 to $4.7 trillion by 2030. This paper explores the four predominant dementia types. These are Alzheimer's disease, Vascular dementia, Lewy body dementia, and Frontotemporal dementia. Each exclusive type has discrete etiologies, symptoms, and progression patterns.

Description

Alzheimer's disease, responsible for about 70% of demenetias worldwide, is closely linked to amyloid plaques and tau tangles, while vascular dementia is defined by reduced blood circulation to the brain and cognitive decline. Lewy body dementia is defined by aberrant deposits of alpha-synuclein protein, leading to cognitive fluctuations and visual hallucinations. Frontotemporal dementia is usually seen in younger people and is identified by atrophy of the frontal, prefrontal, and temporal cortex. Recognizing these differences is important for creating targeted interventions and treatments.

Conclusion

This review aims to enhance comprehension of the underlying pathologies, diagnostic challenges, and therapeutic strategies associated with these dementias, ultimately contributing to improved care and management for affected individuals.
痴呆症是一种复杂的认知障碍,具有多种病理机制,对个人和社会都有重大影响。目前,全球有超过5500万人受到影响,预计到2030年,经济负担将从2019年的2.8万亿美元增加到4.7万亿美元。本文探讨了四种主要的痴呆类型。这些是阿尔茨海默病、血管性痴呆、路易体痴呆和额颞叶痴呆。每种类型都有不同的病因、症状和进展模式。阿尔茨海默病占全球痴呆症的70%,与淀粉样斑块和tau蛋白缠结密切相关,而血管性痴呆的定义是大脑血液循环减少和认知能力下降。路易体痴呆的定义是α -突触核蛋白的异常沉积,导致认知波动和视觉幻觉。额颞叶痴呆通常见于年轻人,通过额叶、前额叶和颞叶皮层的萎缩来识别。认识到这些差异对于制定有针对性的干预措施和治疗非常重要。结论:本综述旨在加强对这些痴呆相关的潜在病理、诊断挑战和治疗策略的理解,最终有助于改善患者的护理和管理。
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引用次数: 0
Q4 Medicine Pub Date : 2025-07-02 DOI: 10.1016/j.npg.2025.06.003
Joël Belmin
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引用次数: 0
Hommage à Christophe Trivalle 向Christophe Trivalle致敬
Q4 Medicine Pub Date : 2025-07-02 DOI: 10.1016/j.npg.2025.05.001
Philippe Thomas , Joël Belmin , Marie-Andrée Bruneau , Olivier Drunat , Laurent Farag , Michèle Grosclaude , Cyril Hazif-Thomas , Lisette Volpe-Gillot , Bernard Pradines
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引用次数: 0
Parkinson's disease between old drugs and new digital therapies: A pharmacological review 帕金森氏病的旧药物和新的数字疗法:药理学综述
Q4 Medicine Pub Date : 2025-06-30 DOI: 10.1016/j.npg.2025.04.002
Francesco Ferrara
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates. Current pharmacological treatments, including levodopa and dopamine agonists, mainly offer symptomatic relief but do not modify disease progression. The heterogeneity of clinical manifestations and underlying molecular mechanisms has prompted a shift toward personalized medicine and innovative therapeutic strategies. Among emerging approaches, cell-based therapies — such as stem cell transplantation and induced pluripotent stem cells — aim to restore dopaminergic function and are under active investigation in preclinical and early clinical settings. In parallel, digital therapeutics and wearable technologies offer real-time, objective monitoring of motor and non-motor symptoms, enabling more accurate disease tracking and treatment optimization. These digital tools also facilitate remote patient management and adherence to therapy. Artificial intelligence (AI) has become increasingly integrated into PD research and care, with machine learning algorithms demonstrating high accuracy in early disease detection, symptom monitoring, and risk prediction. Notably, AI-based analyses of data from wearable sensors and digital biomarkers have identified prodromal signs of PD years before clinical diagnosis, offering promising avenues for preventive strategies. While no disease-modifying therapies are currently available, combining pharmacological treatments with advanced technologies and a deeper understanding of disease biology may pave the way for more effective and individualized interventions. The integration of AI, digital health, and cell-based therapies is a paradigm shift in the management and future treatment landscape of Parkinson's disease.
帕金森病(PD)是一种神经退行性疾病,其特征是黑质中多巴胺能神经元的进行性丧失和α-突触核蛋白聚集体的积累。目前的药物治疗,包括左旋多巴和多巴胺激动剂,主要提供症状缓解,但不能改变疾病进展。临床表现和潜在分子机制的异质性促使了个性化医疗和创新治疗策略的转变。在新兴的治疗方法中,以细胞为基础的治疗方法——如干细胞移植和诱导多能干细胞——旨在恢复多巴胺能功能,目前正在临床前和早期临床环境中积极研究。与此同时,数字疗法和可穿戴技术提供了对运动和非运动症状的实时、客观监测,从而实现更准确的疾病跟踪和治疗优化。这些数字工具还促进了远程患者管理和治疗依从性。人工智能(AI)越来越多地融入帕金森病的研究和护理中,机器学习算法在早期疾病检测、症状监测和风险预测方面表现出很高的准确性。值得注意的是,基于人工智能的可穿戴传感器和数字生物标志物数据分析已经在临床诊断前几年识别出PD的前驱症状,为预防策略提供了有希望的途径。虽然目前还没有治疗疾病的方法,但将药物治疗与先进技术和对疾病生物学的更深入了解相结合,可能会为更有效和个性化的干预铺平道路。人工智能、数字健康和细胞疗法的整合是帕金森病管理和未来治疗前景的范式转变。
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引用次数: 0
Création de la grille DATEI pour l’évaluation et l’intervention en art-thérapie 为艺术治疗的评估和干预创建DATEI网格
Q4 Medicine Pub Date : 2025-06-28 DOI: 10.1016/j.npg.2025.04.003
Marie-Claire Benetti Papadacci
L’efficacité de l’art-thérapie dans l’accompagnement des patients souffrant de pathologies neurogénératives reste encore difficile à mesurer de manière standardisée, en raison du manque d’outils validés d’évaluation. La grille DATEI ou dispositif art-thérapeutique d’évaluation et d’intervention propose de combler cette lacune, sur quatre axes principaux : l’engagement artistique, l’expression émotionnelle, l’interaction sociale et les capacités cognitives. L’étude a été menée auprès de 15 patients atteints de la maladie d’Alzheimer dans le cadre d’un essai pilote recruté au Centre mémoire de l’hôpital d’Ajaccio. Les premiers résultats obtenus suggèrent une amélioration notable sur ces quatre critères. La grille DATEI semble constituer un cadre structuré permettant d’adapter les interventions en art-thérapie afin de favoriser une prise en charge plus individualisée.
The effectiveness of art therapy in supporting patients with neurodegenerative diseases remains difficult to measure in a standardized manner due to the lack of validated assessment tools. The DATEI Grid, or Art-Therapy Assessment and Intervention Device, has been developed to fill this gap, focusing on four main approaches: artistic engagement, emotional expression, social interaction, and cognitive abilities. The study was conducted with 15 patients diagnosed with Alzheimer's disease as part of a pilot trial recruiting patients at the Memory Center of Ajaccio Hospital. The first results obtained suggest a notable improvement across these four criteria. The DATEI Grid appears to provide a structured framework for adapting art therapy interventions to promote a more individualized approach to patient care.
由于缺乏有效的评估工具,艺术治疗在支持神经源性疾病患者方面的有效性仍然难以标准化衡量。DATEI网格或评估和干预的艺术治疗设备建议在四个主要轴上填补这一空白:艺术参与、情感表达、社会互动和认知能力。这项研究是在阿雅克肖医院纪念中心招募的15名阿尔茨海默氏症患者中进行的试点试验。初步结果表明,这四个标准都有了显著改善。DATEI网格似乎提供了一个结构化的框架,允许调整艺术治疗干预措施,以促进更个性化的护理。由于缺乏经过验证的评估工具,艺术治疗在支持神经退行性疾病患者方面的有效性仍然难以以标准化的方式衡量。DATEI网格,或艺术治疗评估和干预设备,已经被开发来填补这一空白,专注于四种主要方法:艺术参与、情感表达、社会互动和认知能力。这项研究是在阿雅克肖医院记忆中心招募患者的试点试验的一部分,对15名被诊断为阿尔茨海默氏症的患者进行的。第一个结果表明,这四个标准都有了显著的改善。DATEI网格似乎为适应艺术治疗干预提供了一个结构化的框架,以促进更个性化的患者护理方法。
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引用次数: 0
La place de la société civile dans la lutte contre les maltraitances doit être maintenue 必须保持民间社会在打击虐待行为方面的作用
Q4 Medicine Pub Date : 2025-05-28 DOI: 10.1016/j.npg.2025.04.001
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引用次数: 0
Q4 Medicine Pub Date : 2025-04-16 DOI: 10.1016/j.npg.2025.03.003
Philippe Thomas
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引用次数: 0
La solitude en institution gériatrique : entre état psychique et contexte social 老年机构中的孤独:精神状态与社会环境之间
Q4 Medicine Pub Date : 2025-04-16 DOI: 10.1016/j.npg.2025.03.001
F. Brossard

Objectif

En établissement gériatrique, nombreux sont ceux qui connaissent un sentiment de solitude. Le grand âge et la perte d’un étayage social fragilisent un soutien basé sur des liens pourtant établis de longue date. Nul doute que ce sentiment peut être alors proportionnel au désarrimage social.

Patient

Un résident octogénaire mélancolique exprime souffrir de solitude. Son accompagnement est réalisé par un psychologue clinicien sur 3 ans à fréquence d’un entretien bimensuel. La méthode se base à la fois sur la psychologie clinique d’inspiration psychanalytique kleinienne mais aussi phénoménologique. Une analyse dans l’après-coup constitue la réflexion de cet article.

Résultats

La solitude peut être vécue face à un sentiment de confrontation à de mauvais aspects de soi. L’analyse des phénomènes présentés permet de repérer une certaine angoisse d’anéantissement face à une fragilisation du Moi. En effet, différents mécanismes se mettent en place notamment le clivage et la projection. Le but étant de protéger ce qui peut réassurer et demeure fragile.

Discussion

Si la solitude peut posséder une part créative, la situation présentée montre qu’elle peut également amener une part de souffrance. Le narcissisme ouvre une piste intéressante pour continuer de s’aimer soi-même en l’absence d’un autre bien qu’il demeure plus précaire dans la mélancolie.

Conclusion

Si des facteurs sociaux peuvent expliquer la solitude, cet exemple nous enseigne qu’elle peut avoir également une origine psychique. Il convient d’en connaître les différents mécanismes afin qu’un accompagnement psychothérapique puisse prendre en compte l’angoisse et les processus qui en dérivent.

Objective

In geriatric institutions, many residents experience loneliness, often exacerbated by aging and the loss of social support, which weaken long-established ties. This loneliness frequently correlates with social disengagement.

Method

We conducted a clinical case study of a melancholic octogenarian resident experiencing loneliness. Psychological support was provided through bi-monthly interviews with a clinical psychologist over 3 years. A retrospective analysis was performed using phenomenological and clinical psychological approaches grounded in Kleinian psychoanalysis.

Results

Loneliness can emerge as individuals confront negative self-perceptions. Our analysis identified an anxiety of annihilation in response to the fragility of the Ego. In order to reassure and protect the Ego, different mechanisms are employed, notably splitting and projection.

Discussion

While solitude may hold creative potential, it often provokes suffering, as evidenced in our case study. In the absence of social connections, narcissism may serve as a means of sustaining self-
在老年机构中,许多人感到孤独。老龄化和社会支持的丧失削弱了基于长期关系的支持。毫无疑问,这种感觉可能与社会脱节成正比。一位忧心忡忡的八十多岁居民表示他感到孤独。他的指导由一名临床心理学家进行,为期三年,每两个月进行一次访谈。该方法既基于临床心理学的小精神分析灵感,也基于现象学。事后分析是本文的重点。结果:面对自我消极方面的对抗感,可能会经历孤独。对这些现象的分析使我们有可能在面对自我的脆弱时发现某种毁灭的焦虑。事实上,不同的机制已经到位,特别是分割和投影。我们的目标是保护那些可以让人安心但仍然脆弱的东西。讨论如果孤独可以发挥创造性的作用,那么目前的情况表明,它也可以带来一些痛苦。自恋为我们提供了一条有趣的途径,让我们在没有其他美好事物的情况下继续爱自己,而其他美好事物在忧郁中更不稳定。如果社会因素可以解释孤独,这个例子告诉我们,它也可能有心理原因。了解不同的机制是很重要的,这样心理治疗支持才能考虑到焦虑和由此产生的过程。目标在老年机构中,许多居民经历孤独,往往因年龄和失去社会支持而加剧,这削弱了长期建立的关系。这种孤独通常与社会脱节有关。我们对经历孤独的忧郁的80多岁居民进行了临床案例研究。在过去的3年里,通过每两个月对一名临床心理学家进行一次访谈,提供心理支持。使用以克兰精神分析为基础的现现学和临床心理学方法进行回顾性分析。当个人面对消极的自我认知时,孤独就会出现。我们的分析确定了一种对自我脆弱的反应是湮灭的焦虑。为了恢复和保护自我,使用了不同的机制,特别是分裂和投射。我们的案例研究表明,虽然孤独可能具有创造的潜力,但它往往会带来痛苦。在没有社会联系的情况下,自恋可以作为一种维持自爱的手段,尽管是不稳定的,尤其是在忧郁的背景下。结论:虽然社会因素通常可以解释孤独,但本案例研究强调了孤独的心理基础。认识到这些心理起源对于解决焦虑和防御机制的心理治疗干预至关重要。
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引用次数: 0
Joël Belmin – Rédacteur en chef Joel Belmin—总编
Q4 Medicine Pub Date : 2025-03-26 DOI: 10.1016/j.npg.2025.03.002
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引用次数: 0
期刊
NPG Neurologie - Psychiatrie - Geriatrie
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