Pub Date : 2023-10-05DOI: 10.31089/1026-9428-2023-63-9-611-616
Olga Yu. Korotenko, Egor S. Filimonov, Ilya D. Martynov
Introduction. In the coal industry, 78.7% of employees work in places with harmful working conditions, which play a leading role in the development of not only professional, but also industrial diseases, the leading of which are diseases of the cardiovascular system. The identification of preclinical systolic dysfunction of the left ventricle and the assessment of the role of traditional and professionally determined risk factors for the development of systolic dysfunction of the left ventricle in workers of the main professions of the coal industry is of scientific interest.
The study aims to assess the risk factors for the development of heart failure with a preserved left ventricular ejection fraction in workers of the main professions of the coal industry.
Materials and methods. The study included 101 employees of the main professions of the coal industry and 80 employees of the paramilitary mine rescue unit. The subjects had no somatic pathology, which could lead to structural and functional changes of the heart. The scientists performed echocardiographic and ultrasound examinations of the main arteries according to standard methods and assessed the generally accepted risk factors for the development of cardiovascular pathology (smoking, abdominal obesity, body mass index, total cholesterol, triglycerides, high and low density lipoprotein cholesterol, glycated hemoglobin).
Results. The researchers revealed systolic dysfunction of the left ventricle significantly in miners more often in the form of a decrease in longitudinal deformation (27.7% of miners versus 7.6% of paramilitary rescuers, p=0.0005), while its average value is also significantly lower in miners and has a value below the established norm (–17.2±0.044 and –19.3±0.03, p=0.0005). The authors found no significant differences in the frequency of commonly accepted risk factors: abdominal obesity, smoking, atherosclerosis of the main arteries, dyslipidemia and the level of glycated hemoglobin in miners and workers of the mine rescue unit, as well as in miners, depending on the index of longitudinal deformation of the left ventricle.
Conclusion. The obtained results indicate the need for a prenosological diagnosis of systolic dysfunction of the left ventricle, studying it in dynamics and simultaneously expanding the search for risk factors, which will allow early prevention of this complication in workers in harmful working conditions.
Ethics. The study was conducted in compliance with the standards of the Bioethical Committee of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, established in accordance with the Helsinki Declaration of the World Association "Ethical Principles of Scientific Medical Research with Human Participation" as amended in 2013 and the "Rules of Good Clinical Practice" approved by Order of the Ministry of Health of the Russian Federation dated 01.04.2016 No. 200n. The subjects signed an informed con
{"title":"Risk factors for the development of heart failure with a preserved left ventricular ejection fraction in workers of the main professions of the coal industry","authors":"Olga Yu. Korotenko, Egor S. Filimonov, Ilya D. Martynov","doi":"10.31089/1026-9428-2023-63-9-611-616","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-9-611-616","url":null,"abstract":"Introduction. In the coal industry, 78.7% of employees work in places with harmful working conditions, which play a leading role in the development of not only professional, but also industrial diseases, the leading of which are diseases of the cardiovascular system. The identification of preclinical systolic dysfunction of the left ventricle and the assessment of the role of traditional and professionally determined risk factors for the development of systolic dysfunction of the left ventricle in workers of the main professions of the coal industry is of scientific interest.
 The study aims to assess the risk factors for the development of heart failure with a preserved left ventricular ejection fraction in workers of the main professions of the coal industry.
 Materials and methods. The study included 101 employees of the main professions of the coal industry and 80 employees of the paramilitary mine rescue unit. The subjects had no somatic pathology, which could lead to structural and functional changes of the heart. The scientists performed echocardiographic and ultrasound examinations of the main arteries according to standard methods and assessed the generally accepted risk factors for the development of cardiovascular pathology (smoking, abdominal obesity, body mass index, total cholesterol, triglycerides, high and low density lipoprotein cholesterol, glycated hemoglobin).
 Results. The researchers revealed systolic dysfunction of the left ventricle significantly in miners more often in the form of a decrease in longitudinal deformation (27.7% of miners versus 7.6% of paramilitary rescuers, p=0.0005), while its average value is also significantly lower in miners and has a value below the established norm (–17.2±0.044 and –19.3±0.03, p=0.0005). The authors found no significant differences in the frequency of commonly accepted risk factors: abdominal obesity, smoking, atherosclerosis of the main arteries, dyslipidemia and the level of glycated hemoglobin in miners and workers of the mine rescue unit, as well as in miners, depending on the index of longitudinal deformation of the left ventricle.
 Conclusion. The obtained results indicate the need for a prenosological diagnosis of systolic dysfunction of the left ventricle, studying it in dynamics and simultaneously expanding the search for risk factors, which will allow early prevention of this complication in workers in harmful working conditions.
 Ethics. The study was conducted in compliance with the standards of the Bioethical Committee of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, established in accordance with the Helsinki Declaration of the World Association \"Ethical Principles of Scientific Medical Research with Human Participation\" as amended in 2013 and the \"Rules of Good Clinical Practice\" approved by Order of the Ministry of Health of the Russian Federation dated 01.04.2016 No. 200n. The subjects signed an informed con","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134948065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.31089/1026-9428-2023-63-9-574-585
Anton A. Tonshin, Tatiana A. Tkacheva, Svetlana V. Kautina, Margarita I. Golubeva
Introduction. Experts predict the hygienic standards of medicines in Russia in accordance with the methods common to all medicines (MG 1.1.726-98), developed more than 25 years ago on the basis of experimental materials obtained during the rationing of 66 medicines. By 2023, the content of more than 230 medicines of various pharmacological orientation has already been normalized in the air of the working area. Such an array of experimental materials makes it possible to study the relationship between the values of standard toxicological and pharmacological indicators and hygienic standards approved by law, already within the framework of individual pharmacological groups of drugs with the same mechanism of action, as well as to develop new forecasting approaches taking into account the specifics of pharmacological actions.
The study aims to evaluate existing and develop new computational methods for predicting hygienic standards for the content of medicines in the air of the working area, taking into account the specifics of pharmacological action on the example of a group of nonsteroidal anti-inflammatory drugs.
Materials and methods. Scientists studied the pharmacological group of nonsteroidal anti-inflammatory drugs. The main method of the study was a multiple correlation and regression analysis of the relationship between the values of hygienic standards and the values of toxicological and pharmacological parameters. As a mathematical model, the authors adopted a double logarithmic model. We evaluated the suitability of the mathematical model by Fisher's F-criterion, the statistical significance of the regression coefficients by the Student's t-criterion, the quality of approximation by the standard deviation, and the accuracy of the calculation by the average multiplicity of differences.
Results. Experts have identified in a group of 15 non-steroidal anti-inflammatory substances normalized in the air of the working area, a reliable relationship between the values of toxicometry parameters and the values of therapeutic doses, on the one hand, and the values of hygiene standards, on the other. Scientists have developed and selected the most accurate and statistically significant formulas for calculating the safe concentrations of this group of drugs in the air of the working area. We found that the accuracy of the formulas developed by us, taking into account the specifics of the pharmacological action, is higher than that of the formulas from MG 1.1.726-98. From the formulas developed earlier, equations with greater accuracy for the hygienic rationing of nonsteroidal anti-inflammatory drugs have been identified.
Conclusion. Taking into account the specifics of the pharmacological action of medicines when developing mathematical models for calculating the hygienic standard increases the accuracy of the forecast.
{"title":"Development of new methods for predicting hygienic standards for the content of medicines in the air of the working area on the example of non-steroidal anti-inflammatory drugs","authors":"Anton A. Tonshin, Tatiana A. Tkacheva, Svetlana V. Kautina, Margarita I. Golubeva","doi":"10.31089/1026-9428-2023-63-9-574-585","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-9-574-585","url":null,"abstract":"Introduction. Experts predict the hygienic standards of medicines in Russia in accordance with the methods common to all medicines (MG 1.1.726-98), developed more than 25 years ago on the basis of experimental materials obtained during the rationing of 66 medicines. By 2023, the content of more than 230 medicines of various pharmacological orientation has already been normalized in the air of the working area. Such an array of experimental materials makes it possible to study the relationship between the values of standard toxicological and pharmacological indicators and hygienic standards approved by law, already within the framework of individual pharmacological groups of drugs with the same mechanism of action, as well as to develop new forecasting approaches taking into account the specifics of pharmacological actions.
 The study aims to evaluate existing and develop new computational methods for predicting hygienic standards for the content of medicines in the air of the working area, taking into account the specifics of pharmacological action on the example of a group of nonsteroidal anti-inflammatory drugs.
 Materials and methods. Scientists studied the pharmacological group of nonsteroidal anti-inflammatory drugs. The main method of the study was a multiple correlation and regression analysis of the relationship between the values of hygienic standards and the values of toxicological and pharmacological parameters. As a mathematical model, the authors adopted a double logarithmic model. We evaluated the suitability of the mathematical model by Fisher's F-criterion, the statistical significance of the regression coefficients by the Student's t-criterion, the quality of approximation by the standard deviation, and the accuracy of the calculation by the average multiplicity of differences.
 Results. Experts have identified in a group of 15 non-steroidal anti-inflammatory substances normalized in the air of the working area, a reliable relationship between the values of toxicometry parameters and the values of therapeutic doses, on the one hand, and the values of hygiene standards, on the other. Scientists have developed and selected the most accurate and statistically significant formulas for calculating the safe concentrations of this group of drugs in the air of the working area. We found that the accuracy of the formulas developed by us, taking into account the specifics of the pharmacological action, is higher than that of the formulas from MG 1.1.726-98. From the formulas developed earlier, equations with greater accuracy for the hygienic rationing of nonsteroidal anti-inflammatory drugs have been identified.
 Conclusion. Taking into account the specifics of the pharmacological action of medicines when developing mathematical models for calculating the hygienic standard increases the accuracy of the forecast.","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134947916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.31089/1026-9428-2023-63-9-605-610
Elena A. Beigel, Irina V. Kudaeva, Ludmila B. Masnavievа
Introduction. In aluminum production workers, the most common occupational pathology is bronchopulmonary diseases, which are characterized by the formation of comorbid pathologies. Oxidative stress plays a key role in the pathogenesis of bronchopulmonary and cardiovascular pathologies.
The study aims to research the indicators of oxidative metabolism and antioxidant protection in aluminum production workers with occupational bronchopulmonary pathology (OBPP) during work and post-contact period.
Materials and methods. During the study, on the basis of the therapeutic department of the clinic at East-Siberian Institute of Medical and Ecological Research, scientists examined 130 patients — workers of aluminum production, with an established professional diagnosis of the bronchopulmonary system both during work and in the post-contact period. The authors have analyzed the indicators of oxidative stress, lipid metabolism and the concentration of antibodies to oxidized low-density lipoproteins.
Results. In patients with OBPP, decreased superoxide dismutase activity was more common during work than in the post-exposure period. About 60% of the examined patients had elevated cholesterol levels, almost 40% had higher reference values of the atherogenicity index and the content of antibodies to oxidized low-density lipoproteins. Cholesterol levels in high-density lipoproteins in individuals with OBPP in the long-term period were lower than in individuals with the same pathology during the work period.
Conclusion. The depletion of antioxidant protection in workers in the post-contact period of the OBPP, the researchers noted in the form of a decrease in the activity of superoxide dismutase in every third person examined, which can lead to the formation of endothelial dysfunction. An increase in the fractions of atherogenic cholesterol is accompanied by a significant increase in the occurrence of a reduced level of high-density lipoprotein cholesterol, which has anti-atherogenic properties.
Ethics. The examination of patients met ethical standards in accordance with the Helsinki Declaration of the World Association "Ethical Principles of Conducting Scientific Medical Research with Human Participation", as amended in 2000 and the "Rules of Clinical Practice in the Russian Federation", approved by Order of the Ministry of Health of the Russian Federation No. 266 of 06/19/2003. All the surveyed signed an informed consent to participate in the study. The protocol of the study was approved by the Ethics Committee of the East Siberian Institute of Medical and Environmental Research (Protocol No. 6 of 10.03.2020).
{"title":"The state of lipid metabolism indicators and the system of peroxidation — antioxidant protection in aluminum production workers with occupational bronchopulmonary pathology","authors":"Elena A. Beigel, Irina V. Kudaeva, Ludmila B. Masnavievа","doi":"10.31089/1026-9428-2023-63-9-605-610","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-9-605-610","url":null,"abstract":"Introduction. In aluminum production workers, the most common occupational pathology is bronchopulmonary diseases, which are characterized by the formation of comorbid pathologies. Oxidative stress plays a key role in the pathogenesis of bronchopulmonary and cardiovascular pathologies.
 The study aims to research the indicators of oxidative metabolism and antioxidant protection in aluminum production workers with occupational bronchopulmonary pathology (OBPP) during work and post-contact period.
 Materials and methods. During the study, on the basis of the therapeutic department of the clinic at East-Siberian Institute of Medical and Ecological Research, scientists examined 130 patients — workers of aluminum production, with an established professional diagnosis of the bronchopulmonary system both during work and in the post-contact period. The authors have analyzed the indicators of oxidative stress, lipid metabolism and the concentration of antibodies to oxidized low-density lipoproteins.
 Results. In patients with OBPP, decreased superoxide dismutase activity was more common during work than in the post-exposure period. About 60% of the examined patients had elevated cholesterol levels, almost 40% had higher reference values of the atherogenicity index and the content of antibodies to oxidized low-density lipoproteins. Cholesterol levels in high-density lipoproteins in individuals with OBPP in the long-term period were lower than in individuals with the same pathology during the work period.
 Conclusion. The depletion of antioxidant protection in workers in the post-contact period of the OBPP, the researchers noted in the form of a decrease in the activity of superoxide dismutase in every third person examined, which can lead to the formation of endothelial dysfunction. An increase in the fractions of atherogenic cholesterol is accompanied by a significant increase in the occurrence of a reduced level of high-density lipoprotein cholesterol, which has anti-atherogenic properties.
 Ethics. The examination of patients met ethical standards in accordance with the Helsinki Declaration of the World Association \"Ethical Principles of Conducting Scientific Medical Research with Human Participation\", as amended in 2000 and the \"Rules of Clinical Practice in the Russian Federation\", approved by Order of the Ministry of Health of the Russian Federation No. 266 of 06/19/2003. All the surveyed signed an informed consent to participate in the study. The protocol of the study was approved by the Ethics Committee of the East Siberian Institute of Medical and Environmental Research (Protocol No. 6 of 10.03.2020).","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134947918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.31089/1026-9428-2023-63-9-617-626
Vladimir S. Roumak, Tatiana A. Myshliavkina, Anton R. Lavrenov, Andrey A. Shelepchikov, Nataliya V. Umnova
Introduction. Landfills of production and consumption waste exist everywhere. Their operation is closely related to unwanted emissions and/or discharges of dioxins. The processes of transfer of these chemicals by air and water flow outside sanitary zones, inclusion in trophic chains, bioaccumulation and overcumulation can contribute to the launch of a toxic process when low subtoxic doses are contained in the medium. It is especially important to take this into account for agro-industrial and residential regions.
The study aims to assess the dioxin pollution of the environment outside the sanitary zone of the solid waste landfill of production and consumption "Lesnaya" (landfill "Lesnaya") by initial (screening) studies of the expected risk to public health.
Materials and methods. Experts characterized dioxin contamination by concentrations of compounds toxic to humans in specially prepared samples, as well as indicators of general toxicity (WHO-TEQ 05). The researchers obtained samples from the surface layers of soil and animal carcasses representing successive generations (groupings) of the winter and summer seasons of the natural population of the bank vole (Clethrionomys glareolus). Concentrations of related substances were measured by high-resolution chromatography-mass spectrometry.
Results. All samples contained dioxins. The good comparability of the profiles of congeners of these substances in soil samples and animal tissues testifies to the general history of their origin, as well as the formation of conditions in the environment for the almost continuous action of small doses of mixtures of these substances on the inhabitants. In soil samples, the values of the WHO-TEQ 05 index were significantly less than the hygienic standard. In animal tissues, concentrations of congeners characterized by pronounced hormone-like toxicity, teratogenic, embryotoxic and carcinogenic properties, primarily 2,3,7,8-tetrachlorodibenzo-p-dioxin, were very high.
Conclusions. The consequences of prolonged exposure to the local natural population of the bank vole of small doses of dioxins in conditions of environmental pollution outside the sanitary zone of the Lesnaya landfill were characterized by the accumulation in their tissues of toxicants with hormone-like properties capable of triggering the mechanisms of formation and development of the toxic process at any concentrations. The scientific and practical significance of the obtained result is determined by the prospects for creating a methodological technique based on it to solve the problem of initial (screening) assessment of the risk to public health, namely the danger of low concentrations (doses) of dioxins polluting the environment.
{"title":"Initial assessment of dioxins polluting the environment outside the sanitary zone of the landfill of production and consumption waste \"Lesnaya\" (Serpukhov, Moscow region)","authors":"Vladimir S. Roumak, Tatiana A. Myshliavkina, Anton R. Lavrenov, Andrey A. Shelepchikov, Nataliya V. Umnova","doi":"10.31089/1026-9428-2023-63-9-617-626","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-9-617-626","url":null,"abstract":"Introduction. Landfills of production and consumption waste exist everywhere. Their operation is closely related to unwanted emissions and/or discharges of dioxins. The processes of transfer of these chemicals by air and water flow outside sanitary zones, inclusion in trophic chains, bioaccumulation and overcumulation can contribute to the launch of a toxic process when low subtoxic doses are contained in the medium. It is especially important to take this into account for agro-industrial and residential regions.
 The study aims to assess the dioxin pollution of the environment outside the sanitary zone of the solid waste landfill of production and consumption \"Lesnaya\" (landfill \"Lesnaya\") by initial (screening) studies of the expected risk to public health.
 Materials and methods. Experts characterized dioxin contamination by concentrations of compounds toxic to humans in specially prepared samples, as well as indicators of general toxicity (WHO-TEQ 05). The researchers obtained samples from the surface layers of soil and animal carcasses representing successive generations (groupings) of the winter and summer seasons of the natural population of the bank vole (Clethrionomys glareolus). Concentrations of related substances were measured by high-resolution chromatography-mass spectrometry.
 Results. All samples contained dioxins. The good comparability of the profiles of congeners of these substances in soil samples and animal tissues testifies to the general history of their origin, as well as the formation of conditions in the environment for the almost continuous action of small doses of mixtures of these substances on the inhabitants. In soil samples, the values of the WHO-TEQ 05 index were significantly less than the hygienic standard. In animal tissues, concentrations of congeners characterized by pronounced hormone-like toxicity, teratogenic, embryotoxic and carcinogenic properties, primarily 2,3,7,8-tetrachlorodibenzo-p-dioxin, were very high.
 Conclusions. The consequences of prolonged exposure to the local natural population of the bank vole of small doses of dioxins in conditions of environmental pollution outside the sanitary zone of the Lesnaya landfill were characterized by the accumulation in their tissues of toxicants with hormone-like properties capable of triggering the mechanisms of formation and development of the toxic process at any concentrations. The scientific and practical significance of the obtained result is determined by the prospects for creating a methodological technique based on it to solve the problem of initial (screening) assessment of the risk to public health, namely the danger of low concentrations (doses) of dioxins polluting the environment.","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134948257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.31089/1026-9428-2023-63-9-564-573
Aleksei A. Polyanichenko, Daria V. Schastlivtseva, Tatiana I. Kotrovskaya, Viktor G. Golubev, Daniil G. Smolyakov
Introduction. The authors have conducted a study of the influence of the conditions of 21-day antiorthostatic hypokinesia (AOSH) on the dynamics of neurophysiological reactions and cognitive functions of a person on the basis of Institute of Biomedical Problems, RAS, with the participation of six healthy male volunteers aged 24 to 40 years (30.7±5.4) who were in bed with hypokinesia in an antiorthostatic position with an angle of inclination –6° relative to the horizon.
The study aims to determine the dynamics of neurophysiological reactions and cognitive functions of a person during a 21–day AOSH (–6°).
Materials and methods. The researchers analyzed the dynamics of cognitive functions based on the results of performing complex dynamic tasks with elements of uncertainty from the CleverBalls software test block. The authors determined the dynamics of neurophysiological reactions by the relative dynamics index (RDI) of the relative power value (RPV) of all the studied ranges of the EEG spectrum. The experts carried out measurements of all indicators before the start of the study (Background), on the 3rd (1st session), 10th (2nd session), 17th (3rd session) and 21st (4th session) days, as well as 3 days after the end of the experiment — aftereffect (After).
Results. Scientists have found an increase in inhibitory processes in the brain as a result of solving complex dynamic tasks with elements of uncertainty in the acute period (3 days) and in the aftereffect. After the acute period and before the end of the experiment, they observed the restoration of brain functions to the background level. An increase in the performance of complex dynamic tasks with elements of uncertainty (according to the indicators "Percentage of correct choice" and "Average harmonic click time") was observed from ten days to the aftereffect inclusive, which indicated, at least, the absence of a decrease in cognitive functions during the 21-day AOSH.
Conclusion. At the end of the experiment, the authors noted a less pronounced increase in Delta and Theta activity than in the acute period, with a simultaneous decrease in Alpha and Beta activity, but at the same time, they did not observe a decrease in the success of cognitive tests.
Ethics. The program of the experiment was approved at the section of the Scientific Council and approved by the Commission on Biomedical Ethics at the Institute of Biomedical Problems, RAS (Protocol No. 599 of 06.10.2021).
{"title":"Dynamics of cognitive and neurophysiological functions of a person in the simulation of weightlessness in terrestrial conditions","authors":"Aleksei A. Polyanichenko, Daria V. Schastlivtseva, Tatiana I. Kotrovskaya, Viktor G. Golubev, Daniil G. Smolyakov","doi":"10.31089/1026-9428-2023-63-9-564-573","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-9-564-573","url":null,"abstract":"Introduction. The authors have conducted a study of the influence of the conditions of 21-day antiorthostatic hypokinesia (AOSH) on the dynamics of neurophysiological reactions and cognitive functions of a person on the basis of Institute of Biomedical Problems, RAS, with the participation of six healthy male volunteers aged 24 to 40 years (30.7±5.4) who were in bed with hypokinesia in an antiorthostatic position with an angle of inclination –6° relative to the horizon.
 The study aims to determine the dynamics of neurophysiological reactions and cognitive functions of a person during a 21–day AOSH (–6°).
 Materials and methods. The researchers analyzed the dynamics of cognitive functions based on the results of performing complex dynamic tasks with elements of uncertainty from the CleverBalls software test block. The authors determined the dynamics of neurophysiological reactions by the relative dynamics index (RDI) of the relative power value (RPV) of all the studied ranges of the EEG spectrum. The experts carried out measurements of all indicators before the start of the study (Background), on the 3rd (1st session), 10th (2nd session), 17th (3rd session) and 21st (4th session) days, as well as 3 days after the end of the experiment — aftereffect (After).
 Results. Scientists have found an increase in inhibitory processes in the brain as a result of solving complex dynamic tasks with elements of uncertainty in the acute period (3 days) and in the aftereffect. After the acute period and before the end of the experiment, they observed the restoration of brain functions to the background level. An increase in the performance of complex dynamic tasks with elements of uncertainty (according to the indicators \"Percentage of correct choice\" and \"Average harmonic click time\") was observed from ten days to the aftereffect inclusive, which indicated, at least, the absence of a decrease in cognitive functions during the 21-day AOSH.
 Conclusion. At the end of the experiment, the authors noted a less pronounced increase in Delta and Theta activity than in the acute period, with a simultaneous decrease in Alpha and Beta activity, but at the same time, they did not observe a decrease in the success of cognitive tests.
 Ethics. The program of the experiment was approved at the section of the Scientific Council and approved by the Commission on Biomedical Ethics at the Institute of Biomedical Problems, RAS (Protocol No. 599 of 06.10.2021).","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134947914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.31089/1026-9428-2023-63-9-596-604
Natalia I. Izmerova, Ludmila P. Kyzmina, Ilona Ya. Chistova, Ludmila M. Bezrykavnikova
Introduction. The causes of occupational skin diseases in 40% of cases are in the absence or unsatisfactory condition of dermatological personal protective equipment. Professional protective skin care remains the main requirement of occupational safety.
The concept of skin screening is giving way to a new approach — the restoration of its own epidermal barrier. Etiopathogenetic prevention technologies are based on inactivation of irritating chemicals and allergens, binding and neutralization of heavy and alkaline earth metal ions, as well as platinoids. The safety assessment of dermatological personal protective equipment is regulated by the state and in accordance with TR CU 019/2011 "On the safety of personal protective equipment", and the effectiveness assessment is voluntary for manufacturers.
The study aims to develop a scheme for conducting clinical testing of evaluation of dermatological personal protective equipment for workers exposed to certain production factors.
Materials and methods. Skin tests are a standard method of allergological diagnosis.
In order to exclude additional sensitization that occurs when taking skin samples with a production allergen, for the reliability of detecting preclinical manifestations of sensitization, the researchers used an in vitro diagnostic method (determination of specific immunoglobulin E — Ig E). To assess the effectiveness of dermatological personal protective equipment on persons working in contact with nickel-containing compounds, the authors determined the nickel content in the blood by atomic absorption method. They evaluated the barrier function of the skin using the "Skin-o-mat" device from "Cosmomed GmbH", Germany.
Results. The specialists proposed a scheme for conducting clinical testing of the evaluation of dermatological personal protective equipment for workers, including an assessment of the barrier function of the skin and in vitro diagnostic methods. The authors evaluated the parameters in dynamics — before and after using. This scheme makes it possible to exclude additional sensitization of employees.
Limitations. The study is limited by the number of workers who underwent periodic medical examinations at the clinic of Izmerov Research Institute of Occupational Health who have contact with nickel compounds in the workplace.
Conclusion. The etiopathogenetic clinical approbation of the evaluation of the effectiveness of dermatological personal protective equipment on workers in production conditions includes an assessment of the skin and an assessment of the barrier-protective function of the skin with the fixation of indicators. To study the effectiveness of skin protection products, an important point is the rational and reasonable selection of groups of approbants on which the study of the protective properties of these products will be carried out.
Ethics. The authors have carried out the study in accordance with the Ethical standard
{"title":"A systematic approach to assessing the effectiveness of personal protective equipment for the skin from the effects of industrial factors","authors":"Natalia I. Izmerova, Ludmila P. Kyzmina, Ilona Ya. Chistova, Ludmila M. Bezrykavnikova","doi":"10.31089/1026-9428-2023-63-9-596-604","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-9-596-604","url":null,"abstract":"Introduction. The causes of occupational skin diseases in 40% of cases are in the absence or unsatisfactory condition of dermatological personal protective equipment. Professional protective skin care remains the main requirement of occupational safety.
 The concept of skin screening is giving way to a new approach — the restoration of its own epidermal barrier. Etiopathogenetic prevention technologies are based on inactivation of irritating chemicals and allergens, binding and neutralization of heavy and alkaline earth metal ions, as well as platinoids. The safety assessment of dermatological personal protective equipment is regulated by the state and in accordance with TR CU 019/2011 \"On the safety of personal protective equipment\", and the effectiveness assessment is voluntary for manufacturers.
 The study aims to develop a scheme for conducting clinical testing of evaluation of dermatological personal protective equipment for workers exposed to certain production factors.
 Materials and methods. Skin tests are a standard method of allergological diagnosis.
 In order to exclude additional sensitization that occurs when taking skin samples with a production allergen, for the reliability of detecting preclinical manifestations of sensitization, the researchers used an in vitro diagnostic method (determination of specific immunoglobulin E — Ig E). To assess the effectiveness of dermatological personal protective equipment on persons working in contact with nickel-containing compounds, the authors determined the nickel content in the blood by atomic absorption method. They evaluated the barrier function of the skin using the \"Skin-o-mat\" device from \"Cosmomed GmbH\", Germany.
 Results. The specialists proposed a scheme for conducting clinical testing of the evaluation of dermatological personal protective equipment for workers, including an assessment of the barrier function of the skin and in vitro diagnostic methods. The authors evaluated the parameters in dynamics — before and after using. This scheme makes it possible to exclude additional sensitization of employees.
 Limitations. The study is limited by the number of workers who underwent periodic medical examinations at the clinic of Izmerov Research Institute of Occupational Health who have contact with nickel compounds in the workplace.
 Conclusion. The etiopathogenetic clinical approbation of the evaluation of the effectiveness of dermatological personal protective equipment on workers in production conditions includes an assessment of the skin and an assessment of the barrier-protective function of the skin with the fixation of indicators. To study the effectiveness of skin protection products, an important point is the rational and reasonable selection of groups of approbants on which the study of the protective properties of these products will be carried out.
 Ethics. The authors have carried out the study in accordance with the Ethical standard ","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134947915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.31089/1026-9428-2023-63-9-586-595
Svetlana V. Voronkova, Alexey A. Abakumov, Georgii S. Torshin, Snezhana V. Malinina, Andrey N. Andrusenko, Yuri V. Grabskii
Introduction. Ensuring the national interests of the Russian Federation in the World Ocean presupposes the development of medical and sanitary support for maritime activities, which currently requires integrated approaches in implementing the requirements for the preservation of the health of employees of the Russian fleet established by international legal acts on health and medical care in maritime navigation, of which the Russian Federation is a participant. In this regard, harmonization of legislation and improvement of measures related to the organization and functioning of seafarers' health protection centers are of particular importance.
The study aims to conduct comprehensive legal monitoring of national regulatory and methodological documents regulating the activities of seafarers' health protection centers in comparison with international standards.
Materials and methods. The authors have studied and analyzed scientific publications for the period from 1980 to 2023 defining the problems of medical and sanitary provision of water transport workers, methodological approaches of the World Health Organization, the International Labor Organization, the International Maritime Organization in this area, as well as current international and Russian regulatory legal acts, information from official websites of executive authorities and organizations.
Results. The study found that today the system of seafarers' health protection, which previously existed in our country, has suffered significantly, and its restoration requires an integrated approach and centralization of medical support for maritime activities in accordance with the Maritime Doctrine of the Russian Federation and the Concept of Development of the Russian Federation Marine medicine. To this end, in the structure of organizations subordinate to the FMBA of Russia, in large port cities, head and regional centers for the protection of seafarers' health were established, carrying out accounting and analytical, organizational and methodological, regulatory, therapeutic and preventive, expert, scientific and educational activities. An important direction in the work of these centers is the implementation of preventive measures and the identification of occupational and work-related diseases. For the successful development of a unified system of medical and sanitary support for employees of the marine and river fleet, it is advisable to assign the functions of regulatory regulation in this area to the FMBA of Russia.
Conclusion. The restoration of a full-fledged domestic system of providing medical care to water transport workers is possible through the creation and regulatory consolidation of the activities of seafarers' health protection centers in the structure of the FMBA organizations of Russia, which is an essential condition for achieving compliance of the national maritime policy with international requirements in the field of health and safety of navigation
{"title":"Regulatory and legal bases for the establishment and functioning of seafarers' health protection centers in the Russian Federation","authors":"Svetlana V. Voronkova, Alexey A. Abakumov, Georgii S. Torshin, Snezhana V. Malinina, Andrey N. Andrusenko, Yuri V. Grabskii","doi":"10.31089/1026-9428-2023-63-9-586-595","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-9-586-595","url":null,"abstract":"Introduction. Ensuring the national interests of the Russian Federation in the World Ocean presupposes the development of medical and sanitary support for maritime activities, which currently requires integrated approaches in implementing the requirements for the preservation of the health of employees of the Russian fleet established by international legal acts on health and medical care in maritime navigation, of which the Russian Federation is a participant. In this regard, harmonization of legislation and improvement of measures related to the organization and functioning of seafarers' health protection centers are of particular importance.
 The study aims to conduct comprehensive legal monitoring of national regulatory and methodological documents regulating the activities of seafarers' health protection centers in comparison with international standards.
 Materials and methods. The authors have studied and analyzed scientific publications for the period from 1980 to 2023 defining the problems of medical and sanitary provision of water transport workers, methodological approaches of the World Health Organization, the International Labor Organization, the International Maritime Organization in this area, as well as current international and Russian regulatory legal acts, information from official websites of executive authorities and organizations.
 Results. The study found that today the system of seafarers' health protection, which previously existed in our country, has suffered significantly, and its restoration requires an integrated approach and centralization of medical support for maritime activities in accordance with the Maritime Doctrine of the Russian Federation and the Concept of Development of the Russian Federation Marine medicine. To this end, in the structure of organizations subordinate to the FMBA of Russia, in large port cities, head and regional centers for the protection of seafarers' health were established, carrying out accounting and analytical, organizational and methodological, regulatory, therapeutic and preventive, expert, scientific and educational activities. An important direction in the work of these centers is the implementation of preventive measures and the identification of occupational and work-related diseases. For the successful development of a unified system of medical and sanitary support for employees of the marine and river fleet, it is advisable to assign the functions of regulatory regulation in this area to the FMBA of Russia.
 Conclusion. The restoration of a full-fledged domestic system of providing medical care to water transport workers is possible through the creation and regulatory consolidation of the activities of seafarers' health protection centers in the structure of the FMBA organizations of Russia, which is an essential condition for achieving compliance of the national maritime policy with international requirements in the field of health and safety of navigation","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134948064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-25DOI: 10.31089/1026-9428-2023-63-2-102-108
Arthur F. Makarov, Yulia V. Tkachuk, Anton A. Tonshin, Igor V. Bukhtiyarov
Introduction. Critical stage of acute mountain (altitude) sickness, manifesting by loss of consciousness, convulsions, apnea and high risk of death, develops at altitudes above 8 km. Acute oxygen starvation of the central nervous system while significant hypobaric hypoxia is the main mechanism of critical stage of acute mountain sickness. Alpinists and professional guides, extreme athletes are the main risk group. It is proposed to reduce the level of metabolism (artificial hypobiosis induction) to prevent the negative impact of acute hypobaric hypoxia on central nervous system. The study aims to assess the efficiency of the metabolic rate reduction for the organism negative impact prevention while acute hypobaric hypoxia. Materials and methods. Study had 2 stages. The 1st - definition of the possibility of using artificial hypobiosis model. The 2nd - the model efficiency definition. Syrian hamsters 90-110 g weight were used in the study. 5 groups, 8 animals in each. Animals of two experimental groups (1 - on the 1st stage and 1 - is on the 2nd) had intramuscular injections of 1 g/kg Methyldopa (CAS Number 555-30-6). Animals control groups (1 - on the 1st stage and 2 - is on the 2nd) had 0,9% NaCl. Indirect calorimetry was performed on the 1st stage. Oxygen consumption and carbon dioxide elimination speed were measured in each animal group twice: before intramuscular injection and 3 hours after. Critical stage of acute mountain (altitude) sickness was performed on the 2nd stage. In 3 hours after intramuscular injection animals of each group had been placed in hypobaric chamber. 30 kPa underpressure for control group #1 animals and 20 kPa for control group #2 and experimental group animals, speed - 1,25 kPa/s. To avoid CO2 accumulation continuous chamber air flow was made. Continuous visual observation carried out. Consciousness, posture maintenance time, convulsive seizures, agonal breathing, and apnea were registered. Results. 1st stage. Experimental group animals’ mean base oxygen consumption speed was 4,04±0,3 ml/100 g/min, and 2,70±0,11 ml/100 g/min (p<0,01) after intramuscular injection., carbon dioxide elimination speed was 3,17±0,27 ml/100 g/min and 2,26±0,09 ml/100 g/min (p<0,01) respectively. Control group animals’ mean base oxygen consumption speed was 3,80±0,43 ml/100 g/min, and 3,88±0,37 ml/100 g/min after intramuscular injection, carbon dioxide elimination speed was 2,95±0,31 ml/100 g/min and 2,92±0,2 ml/100 g/min, respectively. 2nd stage. 20 kPa control group: since start of exposure the average animal posture maintenance time was 3±2 s, the first convulsion time - 20±3 s, the second convulsion - 56±5 s, agonal breath start - 52±9 s, apnea - 114±26 s. Consciousness absence in all animal was observed. Experimental group: none of the parameters is to register were observed. All animals had consciousness, actively restored their position, while chamber was tilted. The exposure lasted for 20 minutes. 30 kPa control group: 1 animal of 8
{"title":"Artificial hypobiosis as a method of acute altitude illness negative impact reduction","authors":"Arthur F. Makarov, Yulia V. Tkachuk, Anton A. Tonshin, Igor V. Bukhtiyarov","doi":"10.31089/1026-9428-2023-63-2-102-108","DOIUrl":"https://doi.org/10.31089/1026-9428-2023-63-2-102-108","url":null,"abstract":"Introduction. Critical stage of acute mountain (altitude) sickness, manifesting by loss of consciousness, convulsions, apnea and high risk of death, develops at altitudes above 8 km. Acute oxygen starvation of the central nervous system while significant hypobaric hypoxia is the main mechanism of critical stage of acute mountain sickness. Alpinists and professional guides, extreme athletes are the main risk group. It is proposed to reduce the level of metabolism (artificial hypobiosis induction) to prevent the negative impact of acute hypobaric hypoxia on central nervous system. The study aims to assess the efficiency of the metabolic rate reduction for the organism negative impact prevention while acute hypobaric hypoxia. Materials and methods. Study had 2 stages. The 1st - definition of the possibility of using artificial hypobiosis model. The 2nd - the model efficiency definition. Syrian hamsters 90-110 g weight were used in the study. 5 groups, 8 animals in each. Animals of two experimental groups (1 - on the 1st stage and 1 - is on the 2nd) had intramuscular injections of 1 g/kg Methyldopa (CAS Number 555-30-6). Animals control groups (1 - on the 1st stage and 2 - is on the 2nd) had 0,9% NaCl. Indirect calorimetry was performed on the 1st stage. Oxygen consumption and carbon dioxide elimination speed were measured in each animal group twice: before intramuscular injection and 3 hours after. Critical stage of acute mountain (altitude) sickness was performed on the 2nd stage. In 3 hours after intramuscular injection animals of each group had been placed in hypobaric chamber. 30 kPa underpressure for control group #1 animals and 20 kPa for control group #2 and experimental group animals, speed - 1,25 kPa/s. To avoid CO2 accumulation continuous chamber air flow was made. Continuous visual observation carried out. Consciousness, posture maintenance time, convulsive seizures, agonal breathing, and apnea were registered. Results. 1st stage. Experimental group animals’ mean base oxygen consumption speed was 4,04±0,3 ml/100 g/min, and 2,70±0,11 ml/100 g/min (p<0,01) after intramuscular injection., carbon dioxide elimination speed was 3,17±0,27 ml/100 g/min and 2,26±0,09 ml/100 g/min (p<0,01) respectively. Control group animals’ mean base oxygen consumption speed was 3,80±0,43 ml/100 g/min, and 3,88±0,37 ml/100 g/min after intramuscular injection, carbon dioxide elimination speed was 2,95±0,31 ml/100 g/min and 2,92±0,2 ml/100 g/min, respectively. 2nd stage. 20 kPa control group: since start of exposure the average animal posture maintenance time was 3±2 s, the first convulsion time - 20±3 s, the second convulsion - 56±5 s, agonal breath start - 52±9 s, apnea - 114±26 s. Consciousness absence in all animal was observed. Experimental group: none of the parameters is to register were observed. All animals had consciousness, actively restored their position, while chamber was tilted. The exposure lasted for 20 minutes. 30 kPa control group: 1 animal of 8 ","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.31089/1026-9428-2019-59-8-473-478
A. Gudkov, V. Chashchin, A. Demin, O. Popova
Introduction. The relevance of the study is determined by the tasks set in the National project “Demography” (Federal project “Older generation”), and is the need to take into account the functional and psycho-physiological characteristics of older age groups in the system of measures to preserve their health and efficiency in connection with the upcoming increase in the age, giving the right to retire for the majority of the working population.The aim of study was to determine the main patterns in the changes in indicators characterizing the quality of life (QL) and postural balance in women of older age groups who continue to work in their profession.Materials and methods. 166 working women aged 55–64 years (mean age 59±2.8 years) were examined. The sample included women who agreed to participate in the study and who, 12 months after the survey, continued to work and did not plan to stop working during the following year. The first age group (AG) consisted of women whose calendar age (CA) was within 55–59 years (n=89), the second — women aged 60–64 years (n=77). The physical (PCS) and psychological (MCS) components of health-related QOL were determined by the SF–36v2 questionnaire. To evaluate the components of postural balance (CPB), a sensory Organization Test (SOT) was conducted using a computer posturographic (stabilometric) complex “Smart Equitest Balance Manager”.Results. It was found that all medians of QL components in the examined women were above 50 points, i.e. exceeded the general population norm. Comparison of PCS values in AG 55–59 years and 60–64 years showed differences at the level of statistical trend (0.05>p≤0.1). When comparing MCS, no statistically significant differences between the groups were found. The study of the SOT PBC revealed that women aged 60–64 had a slight decrease in the quality of the equilibrium function in functional samples 1 (p=0.008) and 2 (p=0.009), but the quality of the equilibrium function in sample 6 (p=0.005) was higher than in women aged 55–59, which makes it possible to consider this indicator as a predictor that has a positive eff ecton the continuation of employment over 59 years.Conclusions. Thus, the physical and psychological components of QL in working women 55–64 years exceed the general population norm. However, after 59 years there is a decrease in the physical component of QL and there is no decrease in the psychological component of QL, which suggests that the psychological health of women 60 years and older becomes crucial in predicting retirement. After 59 years, working women experience a decrease in the quality of the equilibrium function in functional samples 1 and 2, indicating the beginning of age-related changes in the PBC, which justifies the need to develop and implement physical education and health programs aimed at maintaining the postural balance in 60-year-old women.
{"title":"Assessment of quality of life and postural balance in women of older age groups who continue to work in their profession","authors":"A. Gudkov, V. Chashchin, A. Demin, O. Popova","doi":"10.31089/1026-9428-2019-59-8-473-478","DOIUrl":"https://doi.org/10.31089/1026-9428-2019-59-8-473-478","url":null,"abstract":"Introduction. The relevance of the study is determined by the tasks set in the National project “Demography” (Federal project “Older generation”), and is the need to take into account the functional and psycho-physiological characteristics of older age groups in the system of measures to preserve their health and efficiency in connection with the upcoming increase in the age, giving the right to retire for the majority of the working population.The aim of study was to determine the main patterns in the changes in indicators characterizing the quality of life (QL) and postural balance in women of older age groups who continue to work in their profession.Materials and methods. 166 working women aged 55–64 years (mean age 59±2.8 years) were examined. The sample included women who agreed to participate in the study and who, 12 months after the survey, continued to work and did not plan to stop working during the following year. The first age group (AG) consisted of women whose calendar age (CA) was within 55–59 years (n=89), the second — women aged 60–64 years (n=77). The physical (PCS) and psychological (MCS) components of health-related QOL were determined by the SF–36v2 questionnaire. To evaluate the components of postural balance (CPB), a sensory Organization Test (SOT) was conducted using a computer posturographic (stabilometric) complex “Smart Equitest Balance Manager”.Results. It was found that all medians of QL components in the examined women were above 50 points, i.e. exceeded the general population norm. Comparison of PCS values in AG 55–59 years and 60–64 years showed differences at the level of statistical trend (0.05>p≤0.1). When comparing MCS, no statistically significant differences between the groups were found. The study of the SOT PBC revealed that women aged 60–64 had a slight decrease in the quality of the equilibrium function in functional samples 1 (p=0.008) and 2 (p=0.009), but the quality of the equilibrium function in sample 6 (p=0.005) was higher than in women aged 55–59, which makes it possible to consider this indicator as a predictor that has a positive eff ecton the continuation of employment over 59 years.Conclusions. Thus, the physical and psychological components of QL in working women 55–64 years exceed the general population norm. However, after 59 years there is a decrease in the physical component of QL and there is no decrease in the psychological component of QL, which suggests that the psychological health of women 60 years and older becomes crucial in predicting retirement. After 59 years, working women experience a decrease in the quality of the equilibrium function in functional samples 1 and 2, indicating the beginning of age-related changes in the PBC, which justifies the need to develop and implement physical education and health programs aimed at maintaining the postural balance in 60-year-old women.","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69281461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V S Rukavishnikov, G M Bodienkova, S I Kurchevenko, D V Rusanova, O L Lakhman
Clinical immunologic and electroneuromyographic examination covered patients with vibration disease. Registered- demyelination disorders on lower and upper limbs in vibration disease patients were associated with neurochemical changes in special neural structures (OBM, S-100 protein, DNA, AH-R, DA-R, Ser-R, GAMK-R). Direct proof of demyelination disorders in vibration disease patients are reliable correlation between levels of antibodies to OBM and conduction velocity in distal part of median nerve, in ulnar nerve from elbow bend and lower third of arm, and ulnar residual latency. Diagnosed relations between levels of antibodies to regulatory proteins in nervous tissue (antibodies to OBM and to S-100 protein), neurotransmitters (antibodies to AH-R, DA-R, Ser-R, GAMK-R) and functional parameters of nervous system prove important role of autoimmune reactions in vibration disease pathogenesis.
{"title":"[Role ofneuroautoimmune integration in pathogenesis of vibration disease].","authors":"V S Rukavishnikov, G M Bodienkova, S I Kurchevenko, D V Rusanova, O L Lakhman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical immunologic and electroneuromyographic examination covered patients with vibration disease. Registered- demyelination disorders on lower and upper limbs in vibration disease patients were associated with neurochemical changes in special neural structures (OBM, S-100 protein, DNA, AH-R, DA-R, Ser-R, GAMK-R). Direct proof of demyelination disorders in vibration disease patients are reliable correlation between levels of antibodies to OBM and conduction velocity in distal part of median nerve, in ulnar nerve from elbow bend and lower third of arm, and ulnar residual latency. Diagnosed relations between levels of antibodies to regulatory proteins in nervous tissue (antibodies to OBM and to S-100 protein), neurotransmitters (antibodies to AH-R, DA-R, Ser-R, GAMK-R) and functional parameters of nervous system prove important role of autoimmune reactions in vibration disease pathogenesis.</p>","PeriodicalId":35596,"journal":{"name":"Meditsina truda i promyshlennaia ekologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36653504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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