Meditsina truda i promyshlennaia ekologiia最新文献

The authors estimated fluorine compounds content of workplace air in electrolysis workshops of aluminium production, for various electrolysis technologies. The data cover results of physical and chemical analysis and material constitution of produced toxic dust complexes, urinary excretion levels of fluorine ion and fluorides accumulation in hair of aluminium production workers.

The article deals with frequency data on polymorphism of candidate genes participating in endothelial dysfunction (EDN1 Lys198Asn, NOS3 T786C, AGT Thrl74Met and AGT Met23SThr) in totality with concentrations of their active substances in individuals exposed to mercury. Findings are changes in levels of nitrogen oxide, endothelin-1, angiotensin II metabolites in examinees including those without cardiovascular diseases. The genetic conditionality is connected with unfavorable genotypes of polymorphic variants - Met235Thr of AGT gene and Lys198Asn of EDNI gene. Changes in levels of biochemical markers of endothelial dysfunction in individuals exposed to mercury indicate serious endothelial function disorders and are not genetically determined processes.

Important role in treatment and prophylaxis for vibration disease due to local vibration is played by physical factors. If high frequency components prevalent in occupational vibration, treatment with electric therapy, laser, magnetic fields, lymphatic drainage, hydrotherapy provides influence on leading chains of systemic microangiopathies pathogenesis - dysbalance of regulation influences by vegetative nervous system, vasoconstriction and intravascular changes, vascular permeability and microcirculation disorders. If low frequency coomponents prevalent in occupational vibration, treatment of polyneuropathies and locomotory disorders incorporates trophic processes activation: transcranial electroanalgesia, surface application of mineral waters, manual and subwater massage, ozone therapy, local spark discharges, peloids. Complex use of physical methods also increases human adaptational resources.

The article presents results of study concerning biochemical markers of endothelial dysfunction and structural changes in cardiovascular system of aluminium production workers with initial and advanced symptoms of occupationally related bronchopulmonary diseases. Common pathogenetic traits of cardiovascular diseases with initial and advanced symptoms of occupationally related bronchopulmonary diseases are disordered regulation of vascular tone due to nitrogen and plasmin, atherosclerotic plaques formation and changed cardiomyocytes function. Individuals with initial symptoms of occupationally related bronchopulmonary diseases are characterized by increased cardiomyocytes apoptosis due to circulatory disorders. Mechanisms of cardiovascular diseases for advanced symptoms of occupationally related bronchopulmonary diseases are related to disordered regulation of cellular hemostasis by nitrogen oxide and plasmin, changed regulation via b-adrenoreceptors and altered cardiomyocytes metabolism.

The authors revealed mercury role in pathologic changes of central mechanisms underlying cerebral circulation in metabolic circle, associated with changes in central afferent pathways in thalamic region. Relationship was established between intensity of the diagnosed affect and changes in levels of antibodies to proteins S-100, general myeline protein, myeline-associated glycoprotein - that can indicate general neurodegeneration process. Antibodies level can serve as a marker of demyelination intensity in central pathways under exposure to neurotoxicants.

The authors presented results of hygienic evaluation of various techonologies connected with use of fipronil-based insecticides. Findings are allowable risk of fipronil exposure in workers, if technologic regulations and safety rules met. Exceeded allowable risk in some technologies is due to technologic process features, outdated equipment and poor efficiency of individual protective means - that requires management decisions.

The article deals with problems arising in consideration of relations between disease and occupation. The authors presented and analyzed legal occupational therapy documents that regulate examination for connection between disease and occupational activities. Consideration also covers legal aspects and solutions of debates in complicated examination cases with specific clinical examples of legal expertise, based on experience of FGBNU VSIMEI personnel.

The article presents results of evaluation concerning neurophysiologic and psychoemotional state of pilots with occupational neurosensory deafness. Findings are that pilots with occupational neurosensory deafness demonstrate disorganized type of EEG, supported by fading alpha-rhythm, increased slow wave activity in delta range. Other changes are decreased conduction velocity in distal part of median and ulnar nerves - that indicates development of demyelination processes. Psychologic studies proved that personality structure in pilots with occupational neurosensory deafness has dominant traits of balanced emotional reactions, constructive ways to overcome difficulties.

The authors presented data of chemical analytic control of chlorine compounds level in workplace air of vinyl chloride and polyvinyl chloride production, and biomonitoring results of vinyl chloride and 1.2-dichloroethane metabolite - thiodiacetic acid urinary level in workers of this production. Findings are exceeded hygienic norms on maximal concentrations of 1.2-dichloroethane in a workshop for vinyl chloride production from 1.0 to 2.85 MACs and of vinyl chloride in a workshop for polyvinyl chloride production from 2.06 to 5.52 MACs. Urinary levels of thiodiacetic acid were assessed in workers of vinyl chloride and polyvinyl chloride production in dependence on occupation, length of service and post-contact time.

The article covers analysis and systematization of major internet resources used to train high qualified professionals with higher medical education for competent and successful education of doctors in speciality 31.08.27 Diving medicine.