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Laminin γ1-dependent basement membranes are instrumental to ensure proper olfactory placode shape, position and boundary with the brain, as well as olfactory axon development. 依赖于层粘连蛋白γ1的基底膜对于确保嗅胎盘的形状、位置、与大脑的边界以及嗅轴突的发育至关重要。
Q2 Social Sciences Pub Date : 2024-08-29 DOI: 10.1101/2023.06.29.547040
P Tignard, K Pottin, A Geeverding, M Doulazmi, M Cabrera, C Fouquet, M Liffran, J Fouchard, M Rosello, S Albadri, F Del Bene, A Trembleau, M A Breau

Despite recent progress, the complex roles played by the extracellular matrix in development and disease are still far from being fully understood. Here, we took advantage of the zebrafish sly mutation which affects Laminin γ1, a major component of basement membranes, to explore its role in the development of the olfactory system. Following a detailed characterisation of Laminin distribution in the developing olfactory circuit, we analysed basement membrane integrity, olfactory placode and brain morphogenesis, and olfactory axon development in sly mutants, using a combination of immunochemistry, electron microscopy and quantitative live imaging of cell movements and axon behaviours. Our results point to an original and dual contribution of Laminin γ1-dependent basement membranes in organising the border between the olfactory placode and the adjacent brain: they maintain placode shape and position in the face of major brain morphogenetic movements, they establish a robust physical barrier between the two tissues while at the same time allowing the local entry of the sensory axons into the brain and their navigation towards the olfactory bulb. This work thus identifies key roles of Laminin γ1-dependent basement membranes in neuronal tissue morphogenesis and axon development in vivo .

尽管最近取得了一些进展,但人们对细胞外基质在发育和疾病中发挥的复杂作用仍远未完全了解。在这里,我们利用影响基底膜主要成分层粘连蛋白γ1的斑马鱼狡猾突变来探讨它在嗅觉系统发育中的作用。在详细描述了层粘连蛋白在发育中的嗅觉回路中的分布之后,我们采用免疫化学、电子显微镜以及细胞运动和轴突行为的定量活体成像相结合的方法,分析了sly突变体中基底膜的完整性、嗅胎座和脑的形态发生以及嗅轴突的发育。我们的研究结果表明,依赖层粘连蛋白γ1的基底膜在组织嗅球和邻近大脑之间的边界方面具有原创性的双重贡献:它们在面对重大的大脑形态发生运动时保持嗅球的形状和位置,它们在两个组织之间建立了稳固的物理屏障,同时允许感觉轴突进入大脑并向嗅球方向导航。因此,这项工作确定了依赖层粘蛋白γ1的基底膜在体内神经元组织形态发生和轴突发育中的关键作用。
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引用次数: 0
Self-Archiving Adoption in Legal Scholarly Communication: A Literature Review 法律学术交流中的自我存档:文献综述
Q2 Social Sciences Pub Date : 2023-12-05 DOI: 10.1080/13614576.2023.2279760
Fang Wang
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引用次数: 0
Information Seeking Behavior and Information Blockades: An Antithetical Relationship? 信息搜索行为与信息封锁:对立关系?
Q2 Social Sciences Pub Date : 2023-07-03 DOI: 10.1080/13614576.2023.2279763
Salik Parveaz, Asif Khan
ABSTRACT With more than half of the humans on the planet becoming internet users, the amount of information created and accessed is enormous. The Internet has become the most popular medium and source for seeking information. The information-seeking behavior is exhibiting itself. In Kashmir, India – users, businesses, and institutions use Internet to access and disseminate information. But, information blockades seem to hamper the seeking and delivering of information. Information blockades have become an increasing occurrence in various countries worldwide. Most often imposed in regions that witness some form of instability, such as economic or political; information blockades disrupt the primary communication channels. However, studies exploring the relationship between information-seeking behavior and information blockades are scarce. This study is a novel call for focusing research endeavors on information-seeking behavior and its antithetical counterpart, i.e. Information blockade. This paper uses various statistical resources and employs an intensive content analysis method to analyze the literature and identify key themes and patterns of research undertaken on information-seeking behavior and information blockades, especially in Kashmir, India. For the current discourse, ostensibly, the two phenomena have an antithetical relationship and more studies need to be conducted to understand the dynamics of how these two phenomena co-exist.
ABSTRACT 随着地球上一半以上的人成为互联网用户,所创造和获取的信息量巨大。互联网已成为最受欢迎的信息媒介和来源。搜索信息的行为正在表现出来。在印度克什米尔,用户、企业和机构利用互联网获取和传播信息。但是,信息封锁似乎阻碍了信息的寻求和传递。信息封锁在世界各国日益增多。在经济或政治等方面出现某种形式不稳定的地区,信息封锁往往会破坏主要的沟通渠道。然而,探索信息搜索行为与信息封锁之间关系的研究却很少。本研究呼吁将研究重点放在信息搜索行为及其对立面,即信息封锁上。本文利用各种统计资源,并采用密集内容分析法对文献进行分析,确定了有关信息搜索行为和信息封锁的研究的关键主题和模式,尤其是在印度克什米尔地区。从目前的论述来看,这两种现象表面上是对立的,因此需要开展更多的研究来了解这两种现象是如何共存的。
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引用次数: 0
Digital reality in Compulsary Secondary Education: uses, purposes and profiles in social networks 义务中等教育中的数字现实:社交网络中的用途、目的和简介
Q2 Social Sciences Pub Date : 2023-06-07 DOI: 10.1080/13614576.2023.2219244
Silvia Anzano-Oto, Sandra Vázquez-Toledo, Cecilia Latorre-Cosculluela
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引用次数: 0
Analysis of a Records Management Systems at the Northern Region Water Board in Malawi 马拉维北部地区水务委员会记录管理系统分析
Q2 Social Sciences Pub Date : 2023-02-17 DOI: 10.1080/13614576.2023.2175709
Welani Humphrey Msosa, W. Chawinga, G. Chipeta
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引用次数: 0
Research on the Evaluation Methods of English Teaching Quality in the Context of Online Education 网络教育背景下英语教学质量评价方法研究
Q2 Social Sciences Pub Date : 2022-07-03 DOI: 10.1080/13614576.2022.2154691
Xueqiang Wang
ABSTRACT With the development of online education, the evaluation method of teaching quality has also received wide attention. This paper took the “Comprehensive English” course on the Massive Open Online Courses (MOOC) platform as an example, established teaching quality evaluation indicators, designed an evaluation method based on a back-propagation neural network (BPNN), optimized the parameters of the BPNN by the improved genetic algorithm (GA), and established an improved GA-BPNN model. The results found that the error between the output of the improved GA-BPNN model and the actual value was the smallest, between 0.01 and 0.04, showing that the model was stable; the mean absolute percentage error (MAPE) and root-mean-square error (RMSE) of the improved GA-BPNN model were 0.051 and 4.778, respectively, which were superior to BPNN and GA-BPNN models. The results verify the reliability of the improved GA-BPNN model. The model can be applied in practical teaching.
摘要随着在线教育的发展,教学质量的评价方法也受到了广泛关注。本文以大规模开放在线课程(MOOC)平台上的“综合英语”课程为例,建立了教学质量评价指标,设计了一种基于反向传播神经网络(BPNN)的评价方法,利用改进的遗传算法(GA)对BPNN的参数进行了优化,并建立了改进的GA-BPNN模型。结果发现,改进的GA-BPNN模型的输出与实际值之间的误差最小,在0.01-0.04之间,表明该模型是稳定的;改进的GA-BPNN模型的平均绝对百分比误差(MAPE)和均方根误差(RMSE)分别为0.051和4.778,优于BPNN和GA-BPNN模型。结果验证了改进的GA-BPNN模型的可靠性。该模型可用于实际教学。
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引用次数: 0
Research on Multi-Tag Propagation Clustering Method for Microblog Hot Topic Discovery 微博热点话题发现的多标签传播聚类方法研究
Q2 Social Sciences Pub Date : 2022-07-03 DOI: 10.1080/13614576.2022.2157858
Qixiang Wu, Lin He
ABSTRACT In the context of the information explosion, the improvement of people’s living standards has enabled computers and mobile phones to enter the homes of thousands of ordinary people. While promoting the popularization of the Internet, it has also enabled Weibo, a platform for expressing their opinions. Has been rapidly developed. With the continuous development of Weibo, the current mainstream Weibo platforms include Sina Weibo, Tencent Weibo, NetEase Weibo and Sohu Weibo. Based on the idea of multi-label propagation, this paper comprehensively considers node similarity and node life value and proposes the TCMLPA algorithm for hot word clustering, which can effectively improve the accuracy of public opinion recommendation.
在信息爆炸的大背景下,人们生活水平的提高,使得电脑和手机进入了千家万户。在促进互联网普及的同时,它也使微博成为一个表达意见的平台。已经迅速发展起来。随着微博的不断发展,目前主流的微博平台包括新浪微博、腾讯微博、网易微博和搜狐微博。基于多标签传播思想,综合考虑节点相似度和节点寿命值,提出TCMLPA热词聚类算法,能有效提高舆情推荐的准确率。
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引用次数: 1
A Study of the Effect of Hybrid English Teaching by Teachers Using MOOC Mode MOOC模式下教师混合式英语教学效果研究
Q2 Social Sciences Pub Date : 2022-07-03 DOI: 10.1080/13614576.2022.2155683
Zhiming Liu
ABSTRACT In order to test the improvement effect of the Massive Open Online Courses (MOOC)-based hybrid English teaching mode on the English listening, speaking, reading, and writing skills of students, this study divided 200 college students into two groups. One group was the control group which was taught by the traditional teaching mode, while the other group was the experimental group which was taught by the MOOC-based hybrid teaching mode. The listening, speaking, reading, and writing abilities of the two groups were tested before and after teaching. Moreover, a questionnaire survey was carried out after teaching test. The results showed that the listening, speaking, reading, and writing abilities of the experimental group what was taught by the MOOC-based hybrid English teaching mode was effectively improved. The results of the questionnaire survey also demonstrated that the MOOC-based hybrid English teaching mode was more effective in stimulating students’ interest in learning.
为了检验基于大规模在线开放课程(MOOC)的混合式英语教学模式对学生英语听说读写能力的提高效果,本研究将200名大学生分为两组。一组为对照组,采用传统教学模式进行教学;另一组为实验组,采用基于mooc的混合教学模式进行教学。在教学前后分别测试两组学生的听、说、读、写能力。并在教学测试后进行问卷调查。结果表明,在基于mooc的混合英语教学模式下,实验组学生的听、说、读、写能力得到了有效提高。问卷调查的结果也表明,基于mooc的混合式英语教学模式更能有效激发学生的学习兴趣。
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引用次数: 3
Introduction 介绍
Q2 Social Sciences Pub Date : 2022-07-03 DOI: 10.1080/13614576.2022.2161265
K. Rebmann
Our December issue of New Review of Information Networking (NRIN) represents a time of transition to a new Editor (I’m happy to join NRIN) and a space for refocus on networks of information across the many contexts of library & information science, social media, and higher education. The first article, Sümeyye Akça’s Access beyond borders: Linked Open Data applications on cultural heritage, explores the role linked open data (LOD) applications play in the work of cultural memory institutions. With the goal of making collections more discoverable and searchable collections more visible and primed for web-based discovery, Akça draws attention to the many considerations of successfully deploying LOD technologies. Qixiang Wu and Lin He extend the theme of discovery to their work with topic clustering in microblogging, Research on Multi-tag Propagation Clustering Method for Microblog Hot Topic Discovery. With a multi-labelpropagation approach to recommendation algorithms, the team shares ideas for improving the process for connecting users with relevant topics in public opinion. In A study of the effect of hybrid English teaching by teachers using MOOC mode, Zhiming Liu explores hybrid English teaching practices in Massive Open Online Courses (MOOC) learning environments. With a focus on evaluating student learning and engagement, consideration is given to the impact of “learning networks design” to effective educational processes. Shifting the lens from student achievement to faculty performance, Xueqiang Wang’s Research on the evaluation methods of English teaching quality in the context of online education shares a back-propagation neural network (BPNN) method of evaluating online teaching quality. The automation model shared is one step on the road to the application of automation to challenges of quality in online teaching. From the articles in our December issue, it is evident that many researchers working communities connected to NRIN have taken steps toward confronting the challenges of scaling dimensions of discoverability, recommendation activities, and online education. Each of the articles address these issues as they navigate networks of cultural heritage, social media, and distributed learning. As always, if you are engaged in research exploring networks of information, NRIN would love to hear from you. Our Instructions for Authors outline the topics and process for submitting an article for review. If you have questions or wish to bounce ideas off the editor, please review our Aims and Scope and feel free to contact me at the e-mail address below. We particularly NEW REVIEW OF INFORMATION NETWORKING 2022, VOL. 27, NO. 2, 69–70 https://doi.org/10.1080/13614576.2022.2161265
我们12月份的《信息网络新评论》(New Review of Information Networking, NRIN)代表了新编辑(我很高兴加入NRIN)的过渡时期,也是重新关注图书馆与信息科学、社交媒体和高等教育等众多背景下的信息网络的空间。第一篇文章,s meyye aka的《跨越国界的访问:文化遗产的关联开放数据应用》,探讨了关联开放数据(LOD)应用在文化记忆机构工作中的作用。为了使集合更容易被发现,更容易被搜索,并为基于web的发现做好准备,aka提请注意成功部署LOD技术的许多考虑因素。吴其祥和何林将发现的主题扩展到他们的微博话题聚类研究中,《微博热点话题发现的多标签传播聚类方法研究》。通过推荐算法的多标签传播方法,该团队分享了改进将用户与公众舆论中的相关主题联系起来的过程的想法。刘志明在《MOOC模式下教师混合式英语教学效果研究》中,探讨了MOOC学习环境下的混合式英语教学实践。以评估学生的学习和参与为重点,考虑“学习网络设计”对有效教育过程的影响。王学强的《在线教育背景下英语教学质量评价方法研究》将视角从学生成绩转移到教师绩效,分享了一种基于反向传播神经网络(BPNN)的在线教学质量评价方法。共享的自动化模型是将自动化应用于网络教学质量挑战的一步。从我们12月份的文章中可以明显看出,许多与NRIN相关的研究人员已经采取措施应对可发现性、推荐活动和在线教育的扩展维度的挑战。每篇文章都在文化遗产、社交媒体和分布式学习的网络中解决了这些问题。和往常一样,如果你正在研究探索信息网络,NRIN很乐意听到你的声音。我们的作者说明概述了提交文章进行审查的主题和过程。如果您有问题或希望向编辑反馈意见,请查看我们的目标和范围,并随时通过以下电子邮件地址与我联系。《信息网络新评论2022》第27卷第2期。2,69 - 70 https://doi.org/10.1080/13614576.2022.2161265
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引用次数: 0
Access Beyond Borders: Linked Open Data Applications on Cultural Heritage 跨国界访问:文化遗产相关开放数据应用
Q2 Social Sciences Pub Date : 2022-07-03 DOI: 10.1080/13614576.2022.2145334
Sümeyye Akça
ABSTRACT The main mission of cultural memory institutions is to protect their collections and to provide access to a wider audience. World Wide Web technology offers different tools to fulfill this mission. Among a range of applications, the most effective is the search engines’ search for metadata of collections. However, search engines are not always able to see all sources caused by various problems. Linked data is a publishing technique that uses standard web technologies to associate data with other data and makes them available on the Web. In available literature, it is seen that many memory institutions use Linked Open Data as a solution to the search engine problem with the main motivation of making their collections more accessible. However, these applications are still not at proficient level. In this study, Linked Open Data studies in the available literature were scanned and a process map was created based on these applications. These applications, which especially require technical knowledge and infrastructure, can be confusing for memory institutions that have not yet participated in the process. In this context, it is clear that the process map created as a result of this study will be enlightening for memory institutions. The most important point on the map is that an extensive decision-making mechanism should be formed with the stakeholders before starting the process and the implementation plan should be developed in detail over the problems of existing projects.
文化记忆机构的主要任务是保护他们的藏品,并为更广泛的受众提供访问渠道。万维网技术为完成这一使命提供了不同的工具。在一系列应用程序中,最有效的是搜索引擎对集合元数据的搜索。然而,搜索引擎并不总是能够看到所有的来源所造成的各种问题。关联数据是一种发布技术,它使用标准的web技术将数据与其他数据关联起来,并使它们在web上可用。在现有文献中,可以看到许多存储机构使用关联开放数据作为搜索引擎问题的解决方案,其主要动机是使其收藏更易于访问。然而,这些应用程序仍然没有达到熟练水平。在这项研究中,对现有文献中的关联开放数据研究进行了扫描,并基于这些应用程序创建了一个流程图。这些特别需要技术知识和基础设施的应用程序可能会使尚未参与该过程的存储机构感到困惑。在这种情况下,很明显,作为这项研究的结果而创建的过程图将对记忆机构具有启发性。地图上最重要的一点是,在启动过程之前,应与利益相关者形成广泛的决策机制,并针对现有项目的问题制定详细的实施计划。
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引用次数: 0
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New Review of Information Networking
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