Journal of Functional Foods最新文献

英文中文

An overview of bovine beta-casomorphin-7 (b-BCM7) and its potential impact on microbiota regulation and digestive health

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-15 DOI: 10.1016/j.jff.2025.106812

Miguel Alejandro Escobar-Charry , María Ximena Quintanilla-Carvajal

This review explores the global production and consumption of bovine milk, highlighting its role in human nutrition. Cow's milk production contributes to household income, food security, and provides essential nutrients (Protein 3.2 %, Fat 3,8 %, Carbohydrates 4,5 %, Calcium 0,12 %, Vitamin B6, B12, D, and C), with over 6 billion people consuming it worldwide. Milk has evolved to meet consumer needs, leading to variations such as lactose-free, skim, and fortified milk. Similarly, the differentiation between A1 and A2 milk has emerged in response to growing interest in their potential health effects. Recent research distinguishes milk based on its β-casein (β-CN) composition, particularly the A1 and A2 variants, which differ in digestion due to the release of bioactive peptides like bovine β-casomorphin-7 (b-BCM7). The amount of b-BCM7 released depends on the β-CN type, with the A1 variant linked to potential effects on the digestive, neurological, and immunological systems, potentially affecting, for example, gut motility and inflammatory responses. However, the microbiota is now recognized as a dynamic organ that contributes to bio-individuality, meaning health effects cannot be generalized. This underscores the importance of alternatives such as A2 milk, which releases less b-BCM7 and is believed to have no adverse effects. Despite concerns, milk remains a nutrient-dense superfood often discouraged in modern diets, potentially depriving people of its benefits. Further research is essential to understand the production of b-BCM7 during digestion and its health effects, clarifying whether its impact occurs during digestion and absorption or directly influences microbiota regulation, helping to provide clearer dietary recommendations.

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引用次数: 0

Inonotus obliquus alleviates proteinuria of MRL/lpr mice by inhibiting ROS-NLRP3-mediated podocyte pyroptosis via facilitating Nrf2 translocation

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-14 DOI: 10.1016/j.jff.2025.106764

Xinxin Sun , Hui Liao , Zhaodi Han , Yuxiang Liu , Rongshan Li

Proteinuria is a main feature of lupus nephritis (LN) in which NLRP3-mediated podocyte pyroptosis further exacerbates proteinuria. Our previous study confirmed the proteinuria-lowering, podocyte-protecting and anti-inflammatory effects of Inonotus obliquus (chaga) in diabetic kidney disease rats. Our in vivo and in vitro studies were conducted in female MRL/lpr mice and human glomerular podocyte cell line treated with IgG from LN patients' serum. Proteinuria changes were detected by urine protein test kit, C3 and ds-DNA by ELISA, renal histopathology and podocyte morphology were studied also. Western blot and RT-PCR were carried out to detect protein and mRNA levels of WT-1, Nephrin, NLRP3, GSDMD-N, Caspase-1 and IL-1β. ROS in podocytes was detected by fluorescent probes and MDA, LDH levels were measured by ELISA, and Nrf2 translocation was detected by immunofluorescence. In vivo study, chaga significantly decreased proteinuria, improved podocyte morphology and kidney pathological changes, meanwhile increased WT-1 and Nephrin expressions and suppressed NLRP3, GSDMD-N, Caspase-1 and IL-1β expressions when compared to the LN model. In vitro study, similar to Nrf2 activator, chaga facilitated Nrf2 translocate from cytosol into nucleus, suppressed ROS, MDA and LDH generation, then mitigated podocyte pyroptosis. The results indicated that the proteinuria-reducing effect of chaga on LN mice may be related to its promotion of Nrf2 translocation, thereby inhibiting NLRP3/Caspase-1/GSDMD-N-mediated podocyte pyroptosis.

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引用次数: 0

Quinoa alleviates the diabetic symptoms of db/db mice by upregulating insulin signaling and modulating gut microbiota composition

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-14 DOI: 10.1016/j.jff.2025.106813

Liucheng Li , Xiaoye Hu , Xuejie Sun, Xiaohong Wei, Hui Zhang, Pingping Wang

Quinoa is ideal for dietary intervention or alleviation of type 2 diabetes mellitus, but its effects on diabetes and underlying mechanisms remain unclear. In this study, the effects of dietary regimens with different quinoa ratios on T2DM symptoms, insulin signaling pathways and gut flora were tested by using db/db mice. The results showed that T2DM symptoms in db/db mice were improved after quinoa dietary intervention, including lower fasting blood glucose, weight loss, enhanced glucose tolerance, lower insulin resistance(IR), improved dyslipidemia, and reduced degree of non-alcoholic fatty liver disease (NAFLD). Interestingly, we also demonstrated that the quinoa diet also activated insulin signaling and improved gut flora diversity. The above results demonstrate that quinoa diet can improve T2DM symptoms in db/db mice by activating the PI3K/AKT signaling pathway and altering gut microflora diversity, and that quinoa has potential to be a functional food ingredient and therapeutic agent for the treatment of T2DM.

藜麦是膳食干预或缓解 2 型糖尿病的理想食物，但其对糖尿病的影响及其潜在机制仍不清楚。本研究利用 db/db 小鼠测试了不同藜麦比例的饮食方案对 T2DM 症状、胰岛素信号通路和肠道菌群的影响。结果显示，藜麦饮食干预后，db/db小鼠的T2DM症状得到改善，包括空腹血糖降低、体重减轻、糖耐量增强、胰岛素抵抗（IR）降低、血脂异常改善以及非酒精性脂肪肝（NAFLD）程度减轻。有趣的是，我们还证明，藜麦饮食还能激活胰岛素信号传导，改善肠道菌群多样性。上述结果表明，藜麦饮食可通过激活 PI3K/AKT 信号通路和改变肠道微生物菌群多样性来改善 db/db 小鼠的 T2DM 症状，藜麦有望成为治疗 T2DM 的功能性食品配料和治疗剂。

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引用次数: 0

Chemical structure and anti-inflammatory activity of a pectin isolated from sweet potato processing by-products 从甘薯加工副产品中分离出的一种果胶的化学结构和抗炎活性

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-14 DOI: 10.1016/j.jff.2025.106822

Wenting Zhang , Jian Sun , Chanmin Liu , Ruixue Yue , Yi Zhang , Hong Zhu , Chen Ma , Shaoying Deng , Hainan Ruan

This study characterized a pectin polysaccharide named HWSP-1 isolated from sweet potato residue. Structural characterization indicated that HWSP-1 might be composed of →4)-α-D-GalpA-(1 → with methylated GalpA and →2)-α-L-Rhap-(1 → as the main chain, decorated with some neutral polysaccharide such as Ara-, Gal- and Glu- in the form of branched chains. In the lipopolysaccharide (LPS)-induced cells model, HWSP-1 down-regulated the mRNA expression of IL-1β, TNF-α, and IL-6 via inhibiting the TLR4/NF-κB/NLRP3 pathway. The results indicated that HWSP-1 could serve as a potential functional food ingredient.

这项研究对从甘薯渣中分离出的一种名为 HWSP-1 的果胶多糖进行了表征。结构表征表明，HWSP-1可能由→4)-α-D-GalpA-(1→甲基化的GalpA和→2)-α-L-Rhap-(1→作为主链，以支链形式装饰一些中性多糖，如Ara-、Gal-和Glu-。在脂多糖（LPS）诱导的细胞模型中，HWSP-1通过抑制TLR4/NF-κB/NLRP3途径下调IL-1β、TNF-α和IL-6的mRNA表达。研究结果表明，HWSP-1 可作为一种潜在的功能性食品配料。

引用次数: 0

A novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer) as a potential food ingredient to intervene in osteoporosis: A potential mechanism study on promoting the osteogenic differentiation of MC3T3-E1 cells 一种新型磷脂酰磷酸肽（Glu-Asp-Asp-pSer-pSer）作为干预骨质疏松症的潜在食品成分：促进 MC3T3-E1 细胞成骨分化的潜在机制研究

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-14 DOI: 10.1016/j.jff.2025.106821

Tianrui Xue , Tingting Gong , Wei Zhao, Mingran Zhang, Binfei Lv, Huiping Liu, Qi Xu, Xiaowei Zhang

Food-derived peptides with strong calcium-binding and osteogenic activity are promising functional ingredients for osteoporosis intervention. This study aims to explore whether a novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer, EDDpSpS) with excellent calcium binding ability can promote the osteogenic differentiation of MC3T3-E1 cells and its potential mechanism. Network pharmacology analysis of EDDpSpS regulating osteoblast differentiation identified that the focal adhesion was a key signaling pathway, which is closely related to cell differentiation. Molecular simulations demonstrated that EDDpSpS was strongly bound to the target proteins within the focal adhesion signaling pathway and maintains a stable state. In addition, EDDpSpS had the potential to activate the key target protein Src tyrosine kinase (Src). Results of cell experiments showed that EDDpSpS (> 100 μg/mL) significantly promoted the differentiation and mineralization of MC3T3-E1 cells. Transcriptome analysis verified that the expression of paxillin (PXN), Src, actin beta/gamma 1 (ACTG1), and other osteoblast genes were regulated by EDDpSpS, leading to an up-regulation of the focal adhesion. In this study, the effect and the potential mechanism of EDDpSpS on osteoblast differentiation were clarified. EDDpSpS may be used as an effective dual-effect food ingredient for developing functional foods targeting osteoporosis.

{"title":"A novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer) as a potential food ingredient to intervene in osteoporosis: A potential mechanism study on promoting the osteogenic differentiation of MC3T3-E1 cells","authors":"Tianrui Xue , Tingting Gong , Wei Zhao, Mingran Zhang, Binfei Lv, Huiping Liu, Qi Xu, Xiaowei Zhang","doi":"10.1016/j.jff.2025.106821","DOIUrl":"10.1016/j.jff.2025.106821","url":null,"abstract":"<div><div>Food-derived peptides with strong calcium-binding and osteogenic activity are promising functional ingredients for osteoporosis intervention. This study aims to explore whether a novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer, EDDpSpS) with excellent calcium binding ability can promote the osteogenic differentiation of MC3T3-E1 cells and its potential mechanism. Network pharmacology analysis of EDDpSpS regulating osteoblast differentiation identified that the focal adhesion was a key signaling pathway, which is closely related to cell differentiation. Molecular simulations demonstrated that EDDpSpS was strongly bound to the target proteins within the focal adhesion signaling pathway and maintains a stable state. In addition, EDDpSpS had the potential to activate the key target protein Src tyrosine kinase (Src). Results of cell experiments showed that EDDpSpS (> 100 μg/mL) significantly promoted the differentiation and mineralization of MC3T3-E1 cells. Transcriptome analysis verified that the expression of paxillin (PXN), Src, actin beta/gamma 1 (ACTG1), and other osteoblast genes were regulated by EDDpSpS, leading to an up-regulation of the focal adhesion. In this study, the effect and the potential mechanism of EDDpSpS on osteoblast differentiation were clarified. EDDpSpS may be used as an effective dual-effect food ingredient for developing functional foods targeting osteoporosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106821"},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactobacillus helveticus GCL1815 induces salivary IgA production and alleviates common cold-like symptoms: A randomized, double-blind, placebo-controlled, parallel-group comparative study

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-13 DOI: 10.1016/j.jff.2025.106815

Kaoru Kikuchi , Hiroka Wada , Yasuo Saito , Taisuke Uesugi , Kazuma Takahashi , Naoki Azuma , Takashi Mawatari , Kana Nishimura , Yoshitaka Iwama

Lactobacillus helveticus GCL1815 has been shown to suppress cold-like subjective symptoms and activate dendritic cells in prior clinical studies. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to determine the effects of low or high doses of GCL1815 on physical condition and immune indices. In this study, a low-dose group of 6 × 10⁹ GCL1815 cells/day and a high-dose group of 1 × 10¹¹ GCL1815 cells/day were compared to a placebo group. A cold-like symptom questionnaire was established as the primary endpoint of the study. Both the low-dose and high-dose groups showed significant improvement in several systemic and local cold-like symptoms after 8 weeks of GCL1815 intake. This intervention was also found to enhance salivary sIgA secretion rate. No safety concerns were observed even in the high-dose group. These results suggest continuous intake of heat-sterilized GCL1815 for 8 weeks promoted sIgA secretion and reduced systemic and local cold-like symptoms.

{"title":"Lactobacillus helveticus GCL1815 induces salivary IgA production and alleviates common cold-like symptoms: A randomized, double-blind, placebo-controlled, parallel-group comparative study","authors":"Kaoru Kikuchi , Hiroka Wada , Yasuo Saito , Taisuke Uesugi , Kazuma Takahashi , Naoki Azuma , Takashi Mawatari , Kana Nishimura , Yoshitaka Iwama","doi":"10.1016/j.jff.2025.106815","DOIUrl":"10.1016/j.jff.2025.106815","url":null,"abstract":"<div><div><em>Lactobacillus helveticus</em> GCL1815 has been shown to suppress cold-like subjective symptoms and activate dendritic cells in prior clinical studies. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to determine the effects of low or high doses of GCL1815 on physical condition and immune indices. In this study, a low-dose group of 6 × 10<sup>9</sup> GCL1815 cells/day and a high-dose group of 1 × 10<sup>11</sup> GCL1815 cells/day were compared to a placebo group. A cold-like symptom questionnaire was established as the primary endpoint of the study. Both the low-dose and high-dose groups showed significant improvement in several systemic and local cold-like symptoms after 8 weeks of GCL1815 intake. This intervention was also found to enhance salivary sIgA secretion rate. No safety concerns were observed even in the high-dose group. These results suggest continuous intake of heat-sterilized GCL1815 for 8 weeks promoted sIgA secretion and reduced systemic and local cold-like symptoms.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106815"},"PeriodicalIF":3.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of the colostrum-containing multi-nutrient dietary supplement on immune, muscle, bone, and cognitive function parameters in the elderly: A randomized, double-blind, placebo-controlled trial

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-13 DOI: 10.1016/j.jff.2025.106816

Nahathai Dukaew , Preeyaporn Klinjan , Ratchanon Inpan , Mingkwan Na Takuathung , Supat Jiranusornkul , Siripat Chaichit , Weerakit Taychaworaditsakul , Jakkrit Aisara , Wichaya Karat , Nut Koonrungsesomboon

Aging leads to declines in immune function, muscle mass, bone density, and cognition. This 12-week randomized, double-blind, placebo-controlled study evaluated the effects of a colostrum-based dietary supplement (COL) in 80 participants aged 55–70 years. Primary outcomes included immune and inflammatory markers, while secondary outcomes assessed serum insulin-like growth factor (IGF)-1 levels, body composition values, bone turnover markers, cognitive function, and safety. The COL group showed significant increases in stool bovine IgG (MD = 2.75 μg/mL, p < 0.0001) and serum IGF-1 (MD = 10.30 ng/mL, p = 0.005), with trends toward higher serum human IgG and anti-inflammatory cytokine IL-10 levels. Other parameters showed no significant changes. COL supplementation was well-tolerated, with no severe adverse events. These findings suggest that COL enhances immune resilience and supports anabolic processes, highlighting its potential to promote healthy aging and improve the quality of life in elderly individuals.

{"title":"Effects of the colostrum-containing multi-nutrient dietary supplement on immune, muscle, bone, and cognitive function parameters in the elderly: A randomized, double-blind, placebo-controlled trial","authors":"Nahathai Dukaew , Preeyaporn Klinjan , Ratchanon Inpan , Mingkwan Na Takuathung , Supat Jiranusornkul , Siripat Chaichit , Weerakit Taychaworaditsakul , Jakkrit Aisara , Wichaya Karat , Nut Koonrungsesomboon","doi":"10.1016/j.jff.2025.106816","DOIUrl":"10.1016/j.jff.2025.106816","url":null,"abstract":"<div><div>Aging leads to declines in immune function, muscle mass, bone density, and cognition. This 12-week randomized, double-blind, placebo-controlled study evaluated the effects of a colostrum-based dietary supplement (COL) in 80 participants aged 55–70 years. Primary outcomes included immune and inflammatory markers, while secondary outcomes assessed serum insulin-like growth factor (IGF)-1 levels, body composition values, bone turnover markers, cognitive function, and safety. The COL group showed significant increases in stool bovine IgG (MD = 2.75 μg/mL, <em>p</em> < 0.0001) and serum IGF-1 (MD = 10.30 ng/mL, <em>p</em> = 0.005), with trends toward higher serum human IgG and anti-inflammatory cytokine IL-10 levels. Other parameters showed no significant changes. COL supplementation was well-tolerated, with no severe adverse events. These findings suggest that COL enhances immune resilience and supports anabolic processes, highlighting its potential to promote healthy aging and improve the quality of life in elderly individuals.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106816"},"PeriodicalIF":3.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic analysis of the Otoprotective effects of green tea extract on age-related hearing loss

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-12 DOI: 10.1016/j.jff.2025.106779

Changye Li , Xiaolin Zhang , Jinjin Zhang , Ruijuan Cao , Peixia Hao , Weichen Wang , Xuehua Liu , Cuijie Shao , Xiuzhen Liu , Yanfei Wang , Ruyi Zhang , Qing Yin Zheng

Background: Age-related hearing loss (ARHL) is a very common complex disease that causes hearing deficits with age. ARHL seriously affects the cognition and quality of life for the elderly. An ideal method of treating or preventing ARHL is currently unavailable. Green tea and its active ingredients can reduce the risk of age-related diseases.

Objective: This study aimed to evaluate the effect of green tea and its important active ingredients such as epigallocatechin gallate (EGCG) on ARHL, as well as to reveal the molecular mechanism underlying this effect.

Methods: Green tea extract (GTE) along with EGCG was given to C57BL/6 J mice over a period of 9 months. The dosage of green tea extract used in this study corresponds to a human acceptable intake level and is within the known safety range. The impact on hearing was measured using the auditory brainstem response. Subsequently, 4D label-free proteomics was utilized to examine the expression of cochlear proteins in the GTE and 12 m groups. Differential protein expression was visualized through volcano plot analysis. Enrichment evaluations of GO and KEGG pathways were performed to uncover biological roles and molecular pathways. Furthermore, proteins within these differential expressions were analyzed using PPI network and VarElect analysis, enhancing the identification of key proteins based on scoring criteria.

Results: GTE-treated mice had better hearing than control ones, whereas EGCG-treated mice had no significant improvement in hearing. GTE-treated mice also showed better cochlear tissue morphology, and less spiral ganglion neuron damage than control ones. 4D label-free proteomics were used to assess the proteomic patterns. A multitude of differentially expressed proteins (59) were identified in the cochlea of GTE-treated mice. Pathway analysis further indicated that these DE proteins were involved in the Cytosolic DNA-sensing pathway, spliceosome, Rap1 signaling, and metabolism process of various substances, such as taurine.

Conclusions: Long-term GTE supplementation ameliorated ARHL in mice through various pathways, suggesting some drug targets for ARHL treatment.

{"title":"Proteomic analysis of the Otoprotective effects of green tea extract on age-related hearing loss","authors":"Changye Li , Xiaolin Zhang , Jinjin Zhang , Ruijuan Cao , Peixia Hao , Weichen Wang , Xuehua Liu , Cuijie Shao , Xiuzhen Liu , Yanfei Wang , Ruyi Zhang , Qing Yin Zheng","doi":"10.1016/j.jff.2025.106779","DOIUrl":"10.1016/j.jff.2025.106779","url":null,"abstract":"<div><div>Background: Age-related hearing loss (ARHL) is a very common complex disease that causes hearing deficits with age. ARHL seriously affects the cognition and quality of life for the elderly. An ideal method of treating or preventing ARHL is currently unavailable. Green tea and its active ingredients can reduce the risk of age-related diseases.</div><div>Objective: This study aimed to evaluate the effect of green tea and its important active ingredients such as epigallocatechin gallate (EGCG) on ARHL, as well as to reveal the molecular mechanism underlying this effect.</div><div>Methods: Green tea extract (GTE) along with EGCG was given to C57BL/6 J mice over a period of 9 months. The dosage of green tea extract used in this study corresponds to a human acceptable intake level and is within the known safety range. The impact on hearing was measured using the auditory brainstem response. Subsequently, 4D label-free proteomics was utilized to examine the expression of cochlear proteins in the GTE and 12 m groups. Differential protein expression was visualized through volcano plot analysis. Enrichment evaluations of GO and KEGG pathways were performed to uncover biological roles and molecular pathways. Furthermore, proteins within these differential expressions were analyzed using PPI network and VarElect analysis, enhancing the identification of key proteins based on scoring criteria.</div><div>Results: GTE-treated mice had better hearing than control ones, whereas EGCG-treated mice had no significant improvement in hearing. GTE-treated mice also showed better cochlear tissue morphology, and less spiral ganglion neuron damage than control ones. 4D label-free proteomics were used to assess the proteomic patterns. A multitude of differentially expressed proteins (59) were identified in the cochlea of GTE-treated mice. Pathway analysis further indicated that these DE proteins were involved in the Cytosolic DNA-sensing pathway, spliceosome, Rap1 signaling, and metabolism process of various substances, such as taurine.</div><div>Conclusions<em>:</em> Long-term GTE supplementation ameliorated ARHL in mice through various pathways, suggesting some drug targets for ARHL treatment.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106779"},"PeriodicalIF":3.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of Hibiscus sabdariffa L. on body composition and airway reactivity in obese asthmatic rats

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-11 DOI: 10.1016/j.jff.2025.106757

Sarah Rebeca Dantas Ferreira , Rayane Fernandes Pessoa , Alissa Maria de Oliveira Martins , Indyra Alencar Duarte Figueiredo , Bárbara Cavalcanti Barros , José Luiz de Brito Alves , Adriano Francisco Alves , Yuri Mangueira do Nascimento , Luiz Henrique César Vasconcelos , Fabiana de Andrade Cavalcante

Obesity worsens asthma symptoms and reduces treatment response, highlighting the potential of Hibiscus sabdariffa (HS), traditionally used for obesity management, as a treatment for obesity-exacerbated asthma. This study evaluated whether HS could prevent body composition, airway function, and reactivity changes in Wistar rats with obesity-exacerbated asthma. Male rats were divided into control (Ctrl), obese asthmatic (Ob + Asth), and HS-treated groups at 250, 500, and 1000 mg/kg. Rats received a high-glycemic diet for 16 weeks and were sensitized to ovalbumin in the last 22 days. HS was administered orally in the last 30 days. In vivo assessments included weight, fasting glucose, body mass index, and pulmonary ventilation, while in vitro tests measured tracheal contraction and lung and adipose histomorphometry. HS prevented weight gain, reduced glucose and adiposity, decreased adipocyte size, and limited tracheal hyperreactivity and peribronchovascular inflammation. These findings support HS as a promising option for treating obesity-exacerbated asthma.

{"title":"Protective effects of Hibiscus sabdariffa L. on body composition and airway reactivity in obese asthmatic rats","authors":"Sarah Rebeca Dantas Ferreira , Rayane Fernandes Pessoa , Alissa Maria de Oliveira Martins , Indyra Alencar Duarte Figueiredo , Bárbara Cavalcanti Barros , José Luiz de Brito Alves , Adriano Francisco Alves , Yuri Mangueira do Nascimento , Luiz Henrique César Vasconcelos , Fabiana de Andrade Cavalcante","doi":"10.1016/j.jff.2025.106757","DOIUrl":"10.1016/j.jff.2025.106757","url":null,"abstract":"<div><div>Obesity worsens asthma symptoms and reduces treatment response, highlighting the potential of <em>Hibiscus sabdariffa</em> (HS), traditionally used for obesity management, as a treatment for obesity-exacerbated asthma. This study evaluated whether HS could prevent body composition, airway function, and reactivity changes in Wistar rats with obesity-exacerbated asthma. Male rats were divided into control (Ctrl), obese asthmatic (Ob + Asth), and HS-treated groups at 250, 500, and 1000 mg/kg. Rats received a high-glycemic diet for 16 weeks and were sensitized to ovalbumin in the last 22 days. HS was administered orally in the last 30 days. In vivo assessments included weight, fasting glucose, body mass index, and pulmonary ventilation, while in vitro tests measured tracheal contraction and lung and adipose histomorphometry. HS prevented weight gain, reduced glucose and adiposity, decreased adipocyte size, and limited tracheal hyperreactivity and peribronchovascular inflammation. These findings support HS as a promising option for treating obesity-exacerbated asthma.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106757"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary metabolites and antioxidant activity of different parts from the medicinal and edible Alpiniae oxyphylla Miq

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2025-04-11 DOI: 10.1016/j.jff.2025.106803

Yajie Xiang , Wencheng Hou , Meiran Wang , Jian Feng , Wenlan Li , Yangyang Liu

Alpinia oxyphylla Miq. is widely used in the production of Chinese medicine and food, and its traditional edible parts are mainly seeds, with less exploitation of the non-medicinal parts shells and leaves, resulting in a serious waste of resources. In this study, four batches of plant materials collected from the main producing areas of A. oxyphylla in China, and the chemical components of seed, shell and leaf from medicinal and non-medicinal parts of them were analyzed by UHPLC-QTRAP-MS/MS, essential oil content (EOC) were determined using water vapor distillation, and the total flavonoids content (TFC), total polyphenols content (TPC), total polysaccharides content (TPSC), and antioxidant activities in vitro were evaluated using UV spectrophotometry, the relationship between chemical components and antioxidant activities were analyzed by canonical correlation analysis. The results showed that a total of 1216 metabolites were identified from the three parts of A. oxyphylla, and only 136 metabolites differed between the traditional non-medicinal and medicinal parts, and the non-medicinal parts was superior to the traditional medicinal parts in terms of TPC, TFC, TPSC and in vitro antioxidant activity, only the EOC was lower than that of the seeds, and the in vitro antioxidant activity of the A. oxyphylla was significantly and positively correlated to the content of TFC and TPC in the metabolites. This study showed that the shells and leaves of the non-medicinal parts of A. oxyphylla also have good prospects for development and application, providing a scientific basis for the comprehensive development and utilization of A. oxyphylla.

{"title":"Secondary metabolites and antioxidant activity of different parts from the medicinal and edible Alpiniae oxyphylla Miq","authors":"Yajie Xiang , Wencheng Hou , Meiran Wang , Jian Feng , Wenlan Li , Yangyang Liu","doi":"10.1016/j.jff.2025.106803","DOIUrl":"10.1016/j.jff.2025.106803","url":null,"abstract":"<div><div><em>Alpinia oxyphylla</em> Miq. is widely used in the production of Chinese medicine and food, and its traditional edible parts are mainly seeds, with less exploitation of the non-medicinal parts shells and leaves, resulting in a serious waste of resources. In this study, four batches of plant materials collected from the main producing areas of <em>A. oxyphylla</em> in China, and the chemical components of seed, shell and leaf from medicinal and non-medicinal parts of them were analyzed by UHPLC-QTRAP-MS/MS, essential oil content (EOC) were determined using water vapor distillation, and the total flavonoids content (TFC), total polyphenols content (TPC), total polysaccharides content (TPSC), and antioxidant activities in vitro were evaluated using UV spectrophotometry, the relationship between chemical components and antioxidant activities were analyzed by canonical correlation analysis. The results showed that a total of 1216 metabolites were identified from the three parts of <em>A. oxyphylla</em>, and only 136 metabolites differed between the traditional non-medicinal and medicinal parts, and the non-medicinal parts was superior to the traditional medicinal parts in terms of TPC, TFC, TPSC and in vitro antioxidant activity, only the EOC was lower than that of the seeds, and the in vitro antioxidant activity of the <em>A. oxyphylla</em> was significantly and positively correlated to the content of TFC and TPC in the metabolites. This study showed that the shells and leaves of the non-medicinal parts of <em>A. oxyphylla</em> also have good prospects for development and application, providing a scientific basis for the comprehensive development and utilization of <em>A. oxyphylla</em>.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106803"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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