Journal of Functional Foods最新文献_第6页

Zingiber officinale Roscoe (ginger) extract alleviates age-induced hepatic lipid profile change in rats during ageing 生姜提取物可减轻大鼠衰老过程中肝脏脂质变化

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1016/j.jff.2026.107159

Sophia Ogechi Ekeuku , Siti Liyana Saud Gany , Jen Kit Tan , Nur Fathiah Abdul Sani , Nur Fatin Nabilah Mohd Sahardi , Mariam Firdhaus Mad Nordin , Suzana Makpol

Lipid metabolism undergoes significant alterations with age, contributing to the onset of age-related diseases. Ginger (Zingiber officinale Roscoe) is known for its antioxidant and anti-inflammatory properties, but its effect on hepatic lipid profiles during ageing remains unclear. This study aimed to investigate age-related lipidomic changes in the liver and evaluate the modulatory effects of ginger extract using untargeted lipidomics. Male Sprague-Dawley rats were divided into young (3 months), adult (9 months), and old (21 months) groups. Each age group was further subdivided into control and treatment groups (n = 10) receiving either distilled water or ginger extract (200 mg/kg/day) via oral gavage for 3 months. Liver function tests (LFTs) and untargeted lipidomic profiling using UHPLC-MS/MS were performed. Statistical analysis included mixed-design ANOVA, oPLS-DA, and pathway enrichment using LION/web. Ageing increased serum albumin (ALB), total protein (TP), globulin (Glo), alkaline phosphatase (ALP), and albumin:globulin (A:G) ratio, particularly in adult rats. Lipidomic analysis identified 985 lipid species, with glycerophospholipids (GP), glycerolipids (GL), sphingolipids (SP), and fatty acyls (FA) being most affected by ageing and ginger treatment. Ageing was associated with increased DG in adults, a decline in ceramide (Cer) and sphingomyelins (SM) in old rats, and an age-dependent change in triacylglycerols (TG), which increased in adults but declined in old rats. Phosphatidylcholines (PE) decreased significantly only in old rats. Ginger supplementation increased FA in adults and modulated TG levels in an age-dependent manner, reducing TG in adults while increasing it in young rats. Correlation analysis revealed weak to moderate associations between specific lipids and LFT markers. These findings support the potential of ginger as a natural intervention to preserve liver health and counteract lipid dysregulation during ageing.

脂质代谢随着年龄的增长而发生显著变化，从而导致与年龄有关的疾病的发生。生姜（Zingiber officinale Roscoe）以其抗氧化和抗炎特性而闻名，但它对衰老过程中肝脏脂质谱的影响尚不清楚。本研究旨在探讨年龄相关的肝脏脂质组学变化，并利用非靶向脂质组学方法评估生姜提取物的调节作用。雄性sd大鼠分为幼龄组（3月龄）、成年组（9月龄）和老年组（21月龄）。每个年龄组进一步细分为对照组和治疗组（n = 10），分别给予蒸馏水或生姜提取物（200 mg/kg/天）灌胃，持续3个月。使用UHPLC-MS/MS进行肝功能测试（LFTs）和非靶向脂质组学分析。统计分析包括混合设计方差分析，oPLS-DA和途径富集使用LION/web。衰老增加了血清白蛋白（ALB）、总蛋白（TP）、球蛋白（Glo）、碱性磷酸酶（ALP）和白蛋白：球蛋白（A:G）比，尤其是在成年大鼠中。脂质组学分析鉴定出985种脂质，其中甘油磷脂（GP）、甘油脂（GL）、鞘脂（SP）和脂肪酰基（FA）受衰老和生姜处理的影响最大。衰老与成人DG增加、老年大鼠神经酰胺（Cer）和鞘磷脂（SM）下降以及甘油三酯（TG）的年龄依赖性变化有关，甘油三酯（TG）在成年大鼠中增加，而在老年大鼠中下降。磷脂酰胆碱（PE）仅在老年大鼠中显著降低。补充生姜增加了成人的FA，并以年龄依赖的方式调节TG水平，降低了成人的TG，同时增加了年轻大鼠的TG。相关分析显示，特定脂质与LFT标志物之间存在弱至中度关联。这些发现支持生姜作为一种自然干预的潜力，以保持肝脏健康和对抗衰老过程中的脂质失调。

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引用次数: 0

Hemp seed fiber supplementation alleviates myocardial hypertrophy in aging mice through activation of mitophagy 补充大麻籽纤维可通过激活线粒体自噬来减轻衰老小鼠心肌肥大

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI: 10.1016/j.jff.2026.107156

Tao Feng , Hong Chen , Yinjun Luo , Zhiyi Zhou , Biao Li , Xiaoyan Fang , Jinhua Wang , Lingling Huang , Suchan Liao

Aging-induced cardiac hypertrophy is a key risk factor for cardiovascular disease (CVD). The gut-heart axis, gut microbiota, and their metabolite short-chain fatty acids (SCFAs)—which regulate cardiac function—have attracted significant attention. Hemp seeds are rich in dietary fiber, which can be fermented by gut microbiota to produce SCFAs. However, whether hemp seed fiber alleviates cardiac hypertrophy in aging mice by improving gut microbiota composition and increasing SCFA levels remains unclear. Male C57BL/6 mice were divided into 5 groups: adult control group (5-month-old, standard diet), old control group (18-month-old, standard diet), and three old mice groups supplemented with low, medium, and high-dose hemp seed fiber group, with a 12-week intervention. Cardiac hypertrophy (thicker ventricular walls, larger cardiomyocyte cross-sectional area) was observed in old mice. Hemp seed fiber significantly improved this phenotype, reduced hypertrophy markers (myh7, bnp), increased SCFA-related microbiota abundance, and elevated serum SCFAs. The mechanism may involve upregulating GPR41, inhibiting excessive Akt phosphorylation, and promoting mitophagy.

衰老引起的心脏肥大是心血管疾病（CVD）的关键危险因素。肠心轴、肠道微生物群及其代谢物短链脂肪酸（SCFAs）——调节心脏功能——引起了极大的关注。大麻籽富含膳食纤维，可通过肠道菌群发酵产生短链脂肪酸。然而，大麻籽纤维是否通过改善肠道菌群组成和增加SCFA水平来减轻衰老小鼠的心脏肥大仍不清楚。将雄性C57BL/6小鼠分为5组：成人对照组（5月龄，标准饮食）、老年对照组（18月龄，标准饮食）和老年小鼠组（添加低、中、高剂量大麻籽纤维组），干预12周。老年小鼠心肌肥厚（心室壁增厚，心肌细胞横截面积增大）。大麻籽纤维显著改善了这种表型，减少了肥大标志物（myh7, bnp），增加了与scfa相关的微生物群丰度，并提高了血清SCFAs。其机制可能涉及上调GPR41，抑制Akt过度磷酸化，促进线粒体自噬。

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引用次数: 0

Unveiling the anticancer potential of isoorientin in digestive system cancers: mechanistic insights and nanoformulation strategies 揭示异荭草苷在消化系统癌症中的抗癌潜力：机制见解和纳米制剂策略

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.jff.2026.107181

Diwakar Aggarwal , Sachin Kumar Mandotra , Jagjit Kaur , Vasudha Datta , Hardeep Singh Tuli , Satish Kumar , Damandeep Kaur , Ritu Chauhan , Shafiul Haque , Pallvi Mishra

Isoorientin, a C-glycosyl flavonoid belonging to the class of polyphenolic compounds, has recently gained attention for its superior pharmacological profile compared to other polyphenols in anticancer research. Unlike many flavonoids, such as quercetin or luteolin, isoorientin exhibits higher stability, stronger antioxidant capacity, and improved water solubility, which contribute to its enhanced bioefficacy and lower cytotoxicity toward normal cells. Present study examines the anticancer efficacy of the flavonoid isoorientin in gastrointestinal malignancies, elucidating its mechanisms of action and the advantages of nanoformulations for enhanced therapeutic administration. Isoorientin has strong anti-proliferative, pro-apoptotic, and anti-angiogenic properties in many digestive cancer models, including colorectal, gastric, and pancreatic cancers. These effects are facilitated by the control of dysregulated signalling pathways, including PI3K/Akt, NF-κB, and MAPK. Isoorientin also increases the susceptibility of cancer cells to chemotherapy and radiation, thereby enhancing total therapeutic effectiveness. Nano-formulation strategies, including liposome and micelle-based systems, have effectively addressed issues of solubility, bioavailability, and systemic toxicity, facilitating targeted administration, increased stability, and greater accumulation at tumour locations. Given its distinctive structural stability, multifaceted anticancer mechanisms, and compatibility with advanced delivery systems, isoorientin stands out as a promising adjunct or alternative therapeutic candidate for digestive cancers. Combining isoorientin with advanced drug delivery systems could improve current treatment outcomes. Further preclinical and clinical research is required to establish its therapeutic viability.

异荭草苷是一种c -糖基类黄酮，属于多酚类化合物，近年来在抗癌研究中因其优越的药理特征而受到关注。与槲皮素或木犀草素等黄酮类化合物不同，异荭草素具有更高的稳定性、更强的抗氧化能力和更好的水溶性，这有助于提高其对正常细胞的生物功效和更低的细胞毒性。本研究探讨了类黄酮异荭草苷在胃肠道恶性肿瘤中的抗癌作用，阐明了其作用机制和纳米制剂增强治疗给药的优势。异荭草苷在许多消化道癌症模型中具有很强的抗增殖、促凋亡和抗血管生成特性，包括结直肠癌、胃癌和胰腺癌。这些作用是通过控制失调的信号通路，包括PI3K/Akt、NF-κB和MAPK来促进的。异荭草素还能增加癌细胞对化疗和放疗的敏感性，从而提高总体治疗效果。纳米制剂策略，包括脂质体和胶束系统，有效地解决了溶解度、生物利用度和全身毒性问题，促进了靶向给药，增加了稳定性，并在肿瘤部位积累更多。鉴于其独特的结构稳定性、多方面的抗癌机制以及与先进的给药系统的兼容性，异荭草苷作为一种有前途的消化系统癌症的辅助或替代治疗候选药物脱颖而出。异荭草苷与先进的给药系统联合使用可以改善目前的治疗效果。需要进一步的临床前和临床研究来确定其治疗可行性。

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引用次数: 0

Agarononaose from red algae delays cardiomyocyte aging by improving mitochondrial function via enhanced oxidative phosphorylation: A mitochondrial transplantation perspective 来自红藻的Agarononaose通过增强氧化磷酸化来改善线粒体功能，从而延缓心肌细胞衰老：线粒体移植的观点

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jff.2025.107131

Tongxiao Luan , Song Hu , Weihong Nie , Jia Liu , Li Jia , Wei Yang , Shan Wang , Nina An , Zhenyu Liao , Xinru Wangqu , Yufei Li , Qiuxia Ji , Jing Zhou , Yongjun Mao

This study found that agarononaose (A9) exhibits the most significant anti-senescence effect on HL-1 cardiomyocytes among agarose-derived oligosaccharides. Meanwhile, we found that this feature appears to be associated with the mechanism of nutritional intervention dysregulation. Further investigation revealed that A9 improved a series of mitochondrial mechanisms, including oxidative phosphorylation (OXPHOS), mitochondrial membrane potential, oxidative stress, the mitochondrial unfolded protein response (UPR^mt), mitochondrial biogenesis, and mitochondrial dynamics. Importantly, through mitochondrial transplantation experiments and OXPHOS inhibition, it was demonstrated that the enhancement of OXPHOS is a primary mechanism through which A9 ameliorates cellular senescence. Moreover, this bioactivity could be transferred to recipient cells via mitochondrial transplantation. This study identifies a natural marine oligosaccharide as a potential functional food and pharmaceutical agent for ameliorating cardiac cell senescence, and elucidates its key mechanisms. Furthermore, we propose a novel research approach based on mitochondrial transplantation for investigating drug interventions targeting mitochondrial function.

本研究发现琼脂糖寡糖对HL-1心肌细胞的抗衰老作用以琼脂糖寡糖（A9）最显著。同时，我们发现这一特征似乎与营养干预失调的机制有关。进一步的研究表明，A9改善了一系列线粒体机制，包括氧化磷酸化（OXPHOS）、线粒体膜电位、氧化应激、线粒体未折叠蛋白反应（UPRmt）、线粒体生物发生和线粒体动力学。重要的是，通过线粒体移植实验和OXPHOS抑制，证明了增强OXPHOS是A9改善细胞衰老的主要机制。此外，这种生物活性可以通过线粒体移植转移到受体细胞。本研究确定了一种天然海洋低聚糖作为一种潜在的功能性食品和药物剂来改善心脏细胞衰老，并阐明了其关键机制。此外，我们提出了一种基于线粒体移植的新研究方法，用于研究针对线粒体功能的药物干预。

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引用次数: 0

Tempeh and microalgae-fortified tempeh exhibit anticancer potential through S-phase arrest and EGFR/PI3K/AKT/mTOR pathway modulation in BT-474 breast cancer cells 豆豉和微藻强化豆豉在BT-474乳腺癌细胞中通过s期阻滞和EGFR/PI3K/AKT/mTOR通路调节显示出抗癌潜力

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-13 DOI: 10.1016/j.jff.2026.107158

Hesti Lina Wiraswati , Nur Akmalia Hidayati , Ilma Fauziah Ma'ruf , Julia Ramadhanti , Enny Rohmawaty , Vira Putri Yarlina , Ardimas Andi Purwita , Kengo Suzuki , Keiichi Mochida

Tempeh, a traditional fermented soybean product, is valued for its nutritional and functional properties. Its health benefits can be enhanced through fortification. The diverse anticancer activities of microalgae pose a promising option for tempeh fortification. This study investigated the anticancer potential of tempeh and algae-fortified tempeh against BT-474 luminal B breast cancer cells. Phytochemical analysis of the 96% ethanol extracts revealed the presence of flavonoids, alkaloids, and high phenolic content. Algae-fortified tempeh reduced the cell viability by up to 60%, surpassing conventional tempeh. Mechanistically, all extracts suppressed EGFR expression, elevated HIF-1α gene, induced S-phase arrest, and reprogrammed PI3K/AKT/mTOR pathway. Spirulina fortification demonstrated a relative predominance of EGFR suppression and PI3K/AKT modulation, potentially influenced by its pinocembrin content, while Euglena fortification uniquely amplified HIF-1α-mediated metabolic stress through compound triad targeting FABP4, AHCY, and BACE1. Flow cytometry confirmed a strong cytostatic effect in a non-lethal manner. These findings highlight algae fortification as a food-biotechnology strategy for pathway-targeted cancer prevention and complementary health applications.

豆豉是一种传统的发酵豆制品，因其营养和功能特性而受到重视。它的健康益处可以通过强化来增强。微藻的多种抗癌活性为豆豉的强化提供了一个有希望的选择。本研究探讨了豆豉和藻类强化豆豉对乳腺癌细胞BT-474的抗癌作用。96%乙醇提取物的植物化学分析显示其含有黄酮类化合物、生物碱和高酚类物质。藻类强化的豆豉使细胞活力降低了60%，超过了传统的豆豉。在机制上，所有提取物均抑制EGFR表达，升高HIF-1α基因，诱导s期阻滞，并重新编程PI3K/AKT/mTOR通路。螺旋藻强化在抑制EGFR和调节PI3K/AKT方面表现出相对优势，这可能受到螺旋藻内皮素含量的影响，而绿螺旋藻强化则通过靶向FABP4、AHCY和BACE1的复合三联体，独特地放大了hif -1α介导的代谢应激。流式细胞术证实在非致死性方面有很强的细胞抑制作用。这些发现强调了藻类强化作为一种食品生物技术策略，可用于靶向途径的癌症预防和补充健康应用。

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引用次数: 0

Garlic as a functional food: a dual therapeutic strategy for cardiovascular diseases and cancer via shared molecular pathways 大蒜作为一种功能性食品：通过共享的分子途径对心血管疾病和癌症的双重治疗策略

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-10 DOI: 10.1016/j.jff.2026.107152

Long Li , Izhar Ahmed , Amal Alotaibi , Luqman Shah , Lin Yang , Muhammad Zahoor , Majid Khan

Garlic, a widely consumed culinary and medicinal plant, has garnered significant scientific interest due to its broad-spectrum health benefits, particularly in the prevention and management of cardiovascular diseases (CVDs) and cancer. The anticancer and cardiovascular protective effects of garlic are closely linked through its capacity to modulate common physiological and pathological pathways, particularly those related to oxidative stress and chronic inflammation. This review compiles evidence on garlic's dual cardioprotective and anticancer effects, which stem from its ability to simultaneously reduce cholesterol, improve vascular stiffness, and disrupt oncogenic processes such as tumor angiogenesis and metastasis. Additionally, the review examines garlic's safety profile, the stability of its various processed forms (raw and aged), as well as its efficacy and regulatory status as a functional food. Finally, to fully elucidate garlic's therapeutic potential within the framework of precision medicine, biomarker-driven clinical trials are essential for the development of standardized formulations. Moreover, to enhance its therapeutic efficacy the integration of artificial intelligence (AI) with garlic-based nanomedicine presents a promising frontier and advancing personalized treatment strategies.

大蒜是一种广泛食用的烹饪和药用植物，由于其广泛的健康益处，特别是在预防和管理心血管疾病（cvd）和癌症方面，已引起了重大的科学兴趣。大蒜的抗癌和心血管保护作用与其调节常见生理和病理途径的能力密切相关，特别是与氧化应激和慢性炎症有关的生理和病理途径。这篇综述收集了大蒜的双重心脏保护和抗癌作用的证据，这源于大蒜同时具有降低胆固醇、改善血管硬度和破坏肿瘤血管生成和转移等致癌过程的能力。此外，该审查审查了大蒜的安全性，其各种加工形式（生的和陈年的）的稳定性，以及其作为功能性食品的功效和监管地位。最后，为了在精准医学框架内充分阐明大蒜的治疗潜力，生物标志物驱动的临床试验对于标准化配方的开发至关重要。此外，人工智能（AI）与大蒜纳米药物的融合为提高其治疗效果提供了一个有前景的前沿和推进个性化治疗策略。

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引用次数: 0

Gut microbiota and serum metabolites reveal the effects of chongqing tuo tea on glucose and lipid metabolism disorders in high-fat diet-fed mice 肠道菌群和血清代谢物揭示重庆二茶对高脂饮食小鼠糖脂代谢紊乱的影响

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI: 10.1016/j.jff.2026.107164

Rui Chang, Hongyu Luo, Shanmin Chen, Xue Chen, Ruiqi Duan, Ying Zhang, Yingfu Zhong

Obesity and its associated metabolic disorders constitute a major and growing global health challenge, creating an urgent need for safe and effective dietary interventions. Chongqing Tuo Tea, a traditionally compressed tea produced from summer-autumn leaves, has a distinctive chemical profile. Although it has been found that Chongqing Tuo Tea extract (TTE) can improve glucose and lipid metabolism, the underlying mechanisms, particularly those mediated via the gut-liver axis, are not well-understood. In the present study, TTE ameliorated hepatic lipid accumulation, attenuated pancreatic damage, improved the integrity of the intestinal barrier, reduced white adipose tissue deposition and promoted its browning, enhanced glucose tolerance, alleviated insulin resistance, and alleviated lipid metabolic disorders and hepatic oxidative stress in high-fat diet (HFD)-fed mice. TTE ameliorated disorders of glucose metabolism and reduced insulin resistance by activating the hepatic AMPK and PI3K/Akt signaling pathways. It restored the gut microbiota by reversing the Firmicutes/Bacteroidetes (F/B) ratio and promoting the proliferation of beneficial bacteria such as Oscillospira and Bacteroides, thereby increasing the production of short-chain fatty acids, particularly acetic, butyric, and propionic acids. Serum metabolomics and pathway enrichment analysis revealed that TTE significantly regulated metabolism-related pathways, including caffeine metabolism; central carbon metabolism in cancer; phenylalanine metabolism; phenylalanine, tyrosine, and tryptophan biosynthesis; ABC transporters; and glycerophospholipid metabolism. Several potential biomarkers of HFD-induced metabolic dysregulation were identified, including L-histidine, uridine monophosphate, shikimate-3-phosphate, arachidonic acid, and diaminopimelic acid. These findings highlight the potential of dietary TTE supplementation as a strategy for mitigating HFD-induced weight gain and metabolic abnormalities.

肥胖及其相关代谢紊乱是一项日益严重的重大全球健康挑战，迫切需要安全有效的饮食干预措施。重庆沱茶是一种传统的压缩茶，由夏秋的茶叶制成，具有独特的化学成分。虽然已经发现重庆两茶提取物（TTE）可以改善糖脂代谢，但其潜在机制，特别是通过肠-肝轴介导的机制尚不清楚。在本研究中，TTE改善了高脂饮食（HFD）喂养小鼠的肝脏脂质积累，减轻了胰腺损伤，改善了肠道屏障的完整性，减少了白色脂肪组织沉积并促进其褐变，增强了葡萄糖耐量，减轻了胰岛素抵抗，减轻了脂质代谢紊乱和肝脏氧化应激。TTE通过激活肝脏AMPK和PI3K/Akt信号通路改善糖代谢紊乱，降低胰岛素抵抗。它通过扭转厚壁菌门/拟杆菌门（F/B）的比例，促进有益菌如示波螺旋菌和拟杆菌的增殖，从而增加短链脂肪酸，特别是乙酸、丁酸和丙酸的产量，从而恢复肠道微生物群。血清代谢组学和途径富集分析显示，TTE显著调节代谢相关途径，包括咖啡因代谢；癌症中心碳代谢；苯丙氨酸代谢;苯丙氨酸、酪氨酸和色氨酸的生物合成；ABC转运蛋白;甘油磷脂代谢。研究人员确定了几种hfd诱导代谢失调的潜在生物标志物，包括l -组氨酸、单磷酸尿苷、莽草酸-3-磷酸、花生四烯酸和二氨基戊酸。这些发现强调了饮食中补充TTE作为减轻hfd引起的体重增加和代谢异常的策略的潜力。

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引用次数: 0

Curcumin as a multi-target nutritional intervention alleviates exercise-induced injuries from overtraining: intervention efficacy and mechanism of action 姜黄素作为多靶点营养干预减轻过度训练所致运动损伤的干预效果及作用机制

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1016/j.jff.2026.107166

Senlin Lei , Shuyue Deng , Ruolan Shi , Yifu Ding , Xiaoan Chen , Xianhui Li

Curcumin (CUR), a natural polyphenol, exerts antioxidant, anti-inflammatory, and metabolic regulatory actions in exercise physiology and may help ameliorate overtraining-induced multi-organ dysfunction and delayed recovery states associated with overtraining syndrome (OTS). This review systematically summarizes the effects of CUR—across different doses, timing/duration regimens, and delivery systems—on exercise performance, functional recovery, and indices of muscle injury and multi-organ pathology in individuals with varying training status. Given that CUR is challenged by insufficient exposure due to low solubility, extensive first-pass metabolism, and rapid clearance, we introduce an “outcome-window–timing/duration–systemic exposure–outcome interpretation” framework to align systemic exposure with the temporal windows of recovery endpoints related to exercise-induced muscle damage (EIMD) (muscle function and muscle-damage–related indices). This framework is intended to improve the practical interpretability of dosing, supplementation timing, and delivery-system selection, while highlighting the decisive role of formulation type in exposure variability and cross-study comparability, as well as the moderating influence of training status on observable responses. Finally, future research directions were proposed, including optimized formulation and personalized supplementation strategies. Collectively, these insights support the development of multi-target, natural product–based interventions in sports medicine and encourage integrating phytochemicals into precision nutrition to promote recovery and optimize performance.

姜黄素（Curcumin， CUR）是一种天然多酚，在运动生理学中具有抗氧化、抗炎和代谢调节作用，可能有助于改善过度训练引起的多器官功能障碍和与过度训练综合征（OTS）相关的延迟恢复状态。这篇综述系统地总结了不同剂量、时间/持续时间方案和给药系统对不同训练状态个体的运动表现、功能恢复、肌肉损伤指标和多器官病理的影响。鉴于低溶解度、广泛的首过代谢和快速清除导致CUR暴露不足，我们引入了一个“结果窗口-时间/持续时间-系统暴露-结果解释”框架，将系统暴露与与运动诱导的肌肉损伤（EIMD）（肌肉功能和肌肉损伤相关指数）相关的恢复终点的时间窗口相结合。该框架旨在提高剂量、补充时间和给药系统选择的实际可解释性，同时强调配方类型在暴露变异性和交叉研究可比性中的决定性作用，以及训练状态对可观察反应的调节作用。最后，提出了今后的研究方向，包括优化配方和个性化补充策略。总的来说，这些见解支持运动医学中多目标、基于天然产品的干预措施的发展，并鼓励将植物化学物质整合到精确营养中，以促进恢复和优化表现。

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引用次数: 0

Activate the gut–adipose Axis: Forsythia tea alleviates diet-induced obesity via gut microbiota–dependent Browning of white adipose tissue 激活肠道脂肪轴：连翘茶通过肠道微生物依赖的白色脂肪组织褐变减轻饮食引起的肥胖

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jff.2025.107149

Yue Lv , Jianchao Wang , Yue Li , Jiawei Wang , Yuekun Zhang , Huiwen Wu

This study investigated the mechanisms by which Forsythia tea (FT) alleviates diet-induced obesity via the gut-adipose axis. Following 8 weeks of high-fat diet (HFD) feeding to induce obesity in male C57BL/6 J mice, the HFD-fed mice were randomized into HFD and HFD + FT groups, with a normal diet (ND) group as control, for a subsequent 4-week intervention. The results demonstrated that FT significantly attenuated HFD-induced body weight gain and improved glucose tolerance and insulin sensitivity. Furthermore, FT effectively reversed dyslipidemia and suppressed systemic inflammation. Mechanistically, FT reshaped the gut microbiota, enhancing alpha diversity and enriching beneficial taxa. These microbial changes were associated with increased colonic short-chain fatty acid (SCFA) levels, particularly butyrate, and reinforced intestinal barrier integrity. Crucially, FT treatment markedly upregulated the expression of uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in inguinal white adipose tissue (iWAT), indicating the activation of WAT browning. Correlation analyses strongly linked the enriched beneficial microbes to the improved metabolic phenotypes. In conclusion, our findings reveal that FT mitigates obesity and metabolic dysfunction by activating a microbiota-dependent gut-adipose axis that promotes WAT browning, supporting its potential as a functional beverage for obesity management.

本研究探讨连翘茶（FT）通过肠道脂肪轴缓解饮食性肥胖的机制。以高脂饮食（HFD）诱导雄性C57BL/6 J小鼠肥胖8周后，将HFD喂养的小鼠随机分为HFD组和HFD + FT组，以正常饮食（ND）组为对照，进行后续4周的干预。结果表明，FT可显著减弱hfd诱导的体重增加，改善葡萄糖耐量和胰岛素敏感性。此外，FT有效地逆转血脂异常和抑制全身炎症。从机制上讲，FT重塑了肠道微生物群，增强了α多样性并丰富了有益的分类群。这些微生物变化与结肠短链脂肪酸（SCFA）水平的增加（尤其是丁酸盐）和肠道屏障完整性的增强有关。重要的是，FT处理显著上调了解偶联蛋白1 （UCP1）和过氧化物酶体增殖物激活受体γ辅助激活因子1- α (PGC-1α)在腹沟白色脂肪组织（iWAT）中的表达，表明WAT褐变活化。相关分析表明，有益微生物的富集与代谢表型的改善密切相关。总之，我们的研究结果表明，FT通过激活微生物依赖的肠道脂肪轴来减轻肥胖和代谢功能障碍，该轴促进WAT褐变，支持其作为肥胖管理功能饮料的潜力。

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引用次数: 0

Metabolomic study on the inhibitory effect of soluble dietary fiber from foxtail millet on colorectal cancer 谷子可溶性膳食纤维对结肠癌抑制作用的代谢组学研究

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-24 DOI: 10.1016/j.jff.2026.107162

Jieya Yang , Ruipeng Yang , Ruijun Su , Lihua Wu , Wenjing Zhao , Shuhua Shan , Runzhi Ren , Jincheng Xu

Colorectal cancer (CRC) is a malignant tumor of the digestive tract, and previous studies demonstrated that soluble dietary fiber from foxtail millet (FMB-SDF) exhibits significant anti-colorectal cancer effects both in vivo and in vitro. However, the metabolic changes of FMB-SDF in colorectal cancer models remain incompletely understood. This study focused on FMB-SDF. Using AOM/DSS to induce CRC in C57BL/6 J mice, an in vivo colorectal cancer model was established. LC-MS untargeted metabolomics technology was used to detect fecal metabolites in each group of mice to find out the potential biomarkers of CRC, to screen the potential metabolic pathways of FMB-SDF to intervene in CRC, and then to explore the mechanism of action of the anti-cancer effect of FMB-SDF based on the metabolic pathways. This study found that FMB-SDF can regulate some microbial metabolites in the intestine, enhance oxidative stress in colon cancer cell line HCT116, inhibit the secretion of inflammatory factors, and exert anti colorectal cancer effects. From the perspective of sphingolipid metabolism, after treatment with Myriocin, the recovery effect of FMB-SDF on weight loss, colon shortening, and intestinal barrier damage in colon cancer mice decreased, confirming that the anti colon cancer effect of FMB-SDF is closely related to the regulation of sphingolipid metabolic pathway. This provides new insights into FMB-SDF as a functional food for the prevention and treatment of colorectal cancer.

结直肠癌（Colorectal cancer， CRC）是一种消化道恶性肿瘤，前期研究表明谷子可溶性膳食纤维（FMB-SDF）在体内和体外均具有显著的抗结直肠癌作用。然而，FMB-SDF在结直肠癌模型中的代谢变化仍不完全清楚。本研究的重点是FMB-SDF。采用AOM/DSS诱导C57BL/ 6j小鼠结直肠癌，建立体内结直肠癌模型。采用LC-MS非靶向代谢组学技术检测各组小鼠的粪便代谢物，寻找CRC的潜在生物标志物，筛选FMB-SDF干预CRC的潜在代谢途径，进而基于代谢途径探索FMB-SDF抗癌作用的作用机制。本研究发现FMB-SDF可调节肠道内部分微生物代谢物，增强结肠癌细胞系HCT116的氧化应激，抑制炎症因子的分泌，发挥抗结直肠癌的作用。从鞘脂代谢的角度来看，肉豆豆素治疗后，FMB-SDF对结肠癌小鼠体重减轻、结肠缩短、肠屏障损伤的恢复作用减弱，证实FMB-SDF的抗结肠癌作用与调节鞘脂代谢途径密切相关。这为FMB-SDF作为预防和治疗结直肠癌的功能性食品提供了新的见解。

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引用次数: 0