Pub Date : 2025-03-12DOI: 10.1016/j.jff.2025.106717
Weiran Li , Xinying Li , Pingping Wang , Heng Zhang
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of central nervous system structure and function. Ischemic stroke (IS) is the most common type of stroke, and its sequelae include neurodegeneration. The progressive degenerative changes are irreversible, and there are currently no effective treatments for neurodegeneration. Procyanidins, also known as proanthocyanidins, are natural compounds that can suppress oxidative stress, neuroinflammation, and abnormal protein aggregation, thereby reducing the occurrence and development of IS and neurodegenerative diseases such as PD. We reviewed relevant in vitro, in vivo, and clinical literature in PubMed, Web of Science, and Scopus databases from May 1998 to December 2024 using the key terms “procyanidins”, “proanthocyanidins”, “Parkinson's disease”, “ischemic stroke”, “oxidative stress”, “neuroinflammation” and“neurodegenerative disease”. We show that procyanidins represent potential new treatments or preventative strategies for PD and IS, as they target multiple implicated pathogenic pathways and can cross the blood-brain barrier.
{"title":"Procyanidins for the treatment of Parkinson's disease and ischemic stroke","authors":"Weiran Li , Xinying Li , Pingping Wang , Heng Zhang","doi":"10.1016/j.jff.2025.106717","DOIUrl":"10.1016/j.jff.2025.106717","url":null,"abstract":"<div><div>Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of central nervous system structure and function. Ischemic stroke (IS) is the most common type of stroke, and its sequelae include neurodegeneration. The progressive degenerative changes are irreversible, and there are currently no effective treatments for neurodegeneration. Procyanidins, also known as proanthocyanidins, are natural compounds that can suppress oxidative stress, neuroinflammation, and abnormal protein aggregation, thereby reducing the occurrence and development of IS and neurodegenerative diseases such as PD. We reviewed relevant <em>in vitro</em>, <em>in vivo</em>, and clinical literature in PubMed, Web of Science, and Scopus databases from May 1998 to December 2024 using the key terms “procyanidins”, “proanthocyanidins”, “Parkinson's disease”, “ischemic stroke”, “oxidative stress”, “neuroinflammation” and“neurodegenerative disease”. We show that procyanidins represent potential new treatments or preventative strategies for PD and IS, as they target multiple implicated pathogenic pathways and can cross the blood-brain barrier.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106717"},"PeriodicalIF":3.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1016/j.jff.2025.106716
Xiaoying Zhu , Silu Liu , Yijia Tang , Weijia Chen , Ying Zong , Jianan Geng , Yan Zhao , Zhongmei He , Rui Du
Aflatoxin B1 (AFB1) is commonly found in food and feed and has toxic effects on the gastrointestinal tract, impacting public health and livestock development. Dihydromyricetin (DHM) is a natural oxanthrone that has been proven to have significant protective effects on the intestines. This study aimed to elucidate the potential mechanism of DHM alleviating AFB1 exposure-intestinal toxicity in mice. In vitro, rat small intestinal crypt epithelial cells (IEC-6) were treated with aflatoxin B1 (0–120 μmol/L) and DHM (0–320 μmol/L). In vivo, BALB/c mice were divided into four groups: control, AFB1(200 μg/kg), DHM-L (AFB1 + DHM-100 mg/kg), and DHM-H (AFB1 + DHM-200 mg/kg), and gavaged for 30 days. The results showed that the viability of IEC-6 cells decreased with increasing mycotoxin concentration. In addition, RT-qPCR, Western blot, and immunofluorescence results showed that DHM significantly reversed AFB1-induced down-regulation of tight junction proteins, inhibition of the Nrf2/HO-1 signaling pathway, increased expression levels of Caspase-3, Bax, and inflammatory factors, and decreased Bcl-2 levels. In in vivo experiments, we also found that chorionic villus height and crypt depth, expression levels of tight junction proteins, Nrf2/HO-1 signaling pathway, Bax, Bcl-2, Caspase-3, and inflammatory factors, as well as intestinal microbiota, were significantly adversely affected in AFB1-exposed mice. However, the microbial diversity was significantly improved and enhanced by the DHM intervention. In conclusion, DHM intervention attenuated aflatoxin B1-induced intestinal injury by remodeling the gut microbiota, activating the Nrf2/HO-1 signaling pathway, strengthening the intestinal barrier, reducing apoptosis, and inhibiting the release of pro-inflammatory cytokines.
{"title":"Dihydromyricetin attenuates aflatoxin B1-induced IEC-6 cell damage and intestinal damage in mice by activating the Nrf2/HO-1 signaling pathway and modulation of gut microbiota.","authors":"Xiaoying Zhu , Silu Liu , Yijia Tang , Weijia Chen , Ying Zong , Jianan Geng , Yan Zhao , Zhongmei He , Rui Du","doi":"10.1016/j.jff.2025.106716","DOIUrl":"10.1016/j.jff.2025.106716","url":null,"abstract":"<div><div>Aflatoxin B1 (AFB1) is commonly found in food and feed and has toxic effects on the gastrointestinal tract, impacting public health and livestock development. Dihydromyricetin (DHM) is a natural oxanthrone that has been proven to have significant protective effects on the intestines. This study aimed to elucidate the potential mechanism of DHM alleviating AFB1 exposure-intestinal toxicity in mice. <em>In vitro</em>, rat small intestinal crypt epithelial cells (IEC-6) were treated with aflatoxin B1 (0–120 μmol/L) and DHM (0–320 μmol/L). <em>In vivo</em>, BALB/c mice were divided into four groups: control, AFB1(200 μg/kg), DHM-L (AFB1 + DHM-100 mg/kg), and DHM-H (AFB1 + DHM-200 mg/kg), and gavaged for 30 days. The results showed that the viability of IEC-6 cells decreased with increasing mycotoxin concentration. In addition, RT-qPCR, Western blot, and immunofluorescence results showed that DHM significantly reversed AFB1-induced down-regulation of tight junction proteins, inhibition of the Nrf2/HO-1 signaling pathway, increased expression levels of Caspase-3, Bax, and inflammatory factors, and decreased Bcl-2 levels. In <em>in vivo</em> experiments, we also found that chorionic villus height and crypt depth, expression levels of tight junction proteins, Nrf2/HO-1 signaling pathway, Bax, Bcl-2, Caspase-3, and inflammatory factors, as well as intestinal microbiota, were significantly adversely affected in AFB1-exposed mice. However, the microbial diversity was significantly improved and enhanced by the DHM intervention. In conclusion, DHM intervention attenuated aflatoxin B1-induced intestinal injury by remodeling the gut microbiota, activating the Nrf2/HO-1 signaling pathway, strengthening the intestinal barrier, reducing apoptosis, and inhibiting the release of pro-inflammatory cytokines.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106716"},"PeriodicalIF":3.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-08DOI: 10.1016/j.jff.2025.106713
Minhee Park , Kyoungae Won , Ji-Hoon Lee , Yuri Park , Myeonghwan Oh , Jun Chang , Jeongrai Lee , Miyeong Lee
Eggshell membrane (ESM, Ovoderm®-AS) contains bioactive compounds like collagen, elastin, hyaluronic acid, glucosamine, and chondroitin sulfate, which promote cellular activity, enhance collagen production, and reduce UV-induced damage. This double-blind, randomized, placebo-controlled trial evaluated the effects of oral ESM supplementation on skin parameters, including wrinkling, elasticity, dermal density, sagging, hydration, transepidermal water loss (TEWL), desquamation, roughness, and serum MMP-2 and MMP-9 levels. One hundred women aged 25–60 were randomized to receive 600 mg/day of ESM or placebo for 12 weeks, with assessments at baseline, 6 weeks, and 12 weeks. ESM significantly improved wrinkling, elasticity, dermal density, sagging, hydration, TEWL, desquamation, and roughness after 12 weeks (p < 0.05). Improvements in elasticity, dermal density, and sagging were observed as early as 6 weeks. No adverse events were reported. In conclusion, ESM is a safe and effective ingredient for improving skin health.
{"title":"Effects of Oral supplementation with eggshell membrane (Ovoderm®-AS) on skin health: A randomized, double-blind, placebo-controlled trial","authors":"Minhee Park , Kyoungae Won , Ji-Hoon Lee , Yuri Park , Myeonghwan Oh , Jun Chang , Jeongrai Lee , Miyeong Lee","doi":"10.1016/j.jff.2025.106713","DOIUrl":"10.1016/j.jff.2025.106713","url":null,"abstract":"<div><div>Eggshell membrane (ESM, Ovoderm®-AS) contains bioactive compounds like collagen, elastin, hyaluronic acid, glucosamine, and chondroitin sulfate, which promote cellular activity, enhance collagen production, and reduce UV-induced damage. This double-blind, randomized, placebo-controlled trial evaluated the effects of oral ESM supplementation on skin parameters, including wrinkling, elasticity, dermal density, sagging, hydration, transepidermal water loss (TEWL), desquamation, roughness, and serum MMP-2 and MMP-9 levels. One hundred women aged 25–60 were randomized to receive 600 mg/day of ESM or placebo for 12 weeks, with assessments at baseline, 6 weeks, and 12 weeks. ESM significantly improved wrinkling, elasticity, dermal density, sagging, hydration, TEWL, desquamation, and roughness after 12 weeks (<em>p</em> < 0.05). Improvements in elasticity, dermal density, and sagging were observed as early as 6 weeks. No adverse events were reported. In conclusion, ESM is a safe and effective ingredient for improving skin health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106713"},"PeriodicalIF":3.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ajoene, a bioactive sulfur-containing compound derived from garlic, exhibits a wide range of pharmacological properties that have garnered substantial scientific interest. This review presents a comprehensive analysis of its biological activities, including anticancer, antidiabetic, anti-inflammatory, antimicrobial, and neuroprotective effects. Several scientific research databases, including Google Scholar, Web of Science, PubMed, SciFinder, SpringerLink, Science Direct, Scopus, and, Wiley Online have been consulted.
Ajoene has been shown to modulate key molecular pathways such as oxidative stress, inflammatory cytokine release, enzyme activity, and cellular apoptosis. These mechanisms contribute to its potential therapeutic applications across various diseases, including cancer, diabetes, cardiovascular disorders, neurodegenerative diseases, and infections. In vitro and in vivo studies consistently highlight ajoene's ability to inhibit tumor growth, reduce hyperglycemia, prevent neurodegeneration, and suppress inflammatory responses. Despite these promising results, the underlying mechanisms of ajoene's bioactivity remain incompletely understood, particularly in the context of complex human pathologies. This review emphasizes the need for more extensive clinical trials and toxicological evaluations to validate the efficacy and safety of ajoene in human populations. As such, ajoene is a promising candidate for developing novel therapeutic interventions, meriting further drug design and development investigation.
{"title":"Unlocking the natural chemical sources, nutritional properties, biological effects, and molecular actions of Ajoene","authors":"Abdelhakim Bouyahya , Fatima Kamari , Nasreddine El Omari , Jihane Touhtouh , Ibrahim Mssillou , Tarik Aanniz , Taoufiq Benali , Asaad Khalid , Ashraf N. Abdalla , Mohamed A.M. Iesa , Khan Wen Goh , Saad Bakrim","doi":"10.1016/j.jff.2025.106714","DOIUrl":"10.1016/j.jff.2025.106714","url":null,"abstract":"<div><div>Ajoene, a bioactive sulfur-containing compound derived from garlic, exhibits a wide range of pharmacological properties that have garnered substantial scientific interest. This review presents a comprehensive analysis of its biological activities, including anticancer, antidiabetic, anti-inflammatory, antimicrobial, and neuroprotective effects. Several scientific research databases, including Google Scholar, Web of Science, PubMed, SciFinder, SpringerLink, Science Direct, Scopus, and, Wiley Online have been consulted.</div><div>Ajoene has been shown to modulate key molecular pathways such as oxidative stress, inflammatory cytokine release, enzyme activity, and cellular apoptosis. These mechanisms contribute to its potential therapeutic applications across various diseases, including cancer, diabetes, cardiovascular disorders, neurodegenerative diseases, and infections. <em>In vitro</em> and <em>in vivo</em> studies consistently highlight ajoene's ability to inhibit tumor growth, reduce hyperglycemia, prevent neurodegeneration, and suppress inflammatory responses. Despite these promising results, the underlying mechanisms of ajoene's bioactivity remain incompletely understood, particularly in the context of complex human pathologies. This review emphasizes the need for more extensive clinical trials and toxicological evaluations to validate the efficacy and safety of ajoene in human populations. As such, ajoene is a promising candidate for developing novel therapeutic interventions, meriting further drug design and development investigation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106714"},"PeriodicalIF":3.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.jff.2025.106710
Chunyan Wang , Xinxin Ma , Yoshimasa Nakamura , Hang Qi
Fucoxanthin (FX) is a natural pigment belonging to the xanthophyll carotenoid, which has been proven to have inhibitory effects on glioblastoma. In our previous study, nano-FX was fabricated through whey protein and flaxseed gum co-encapsulated for improved stability and glial cell (PC12) inhibitory activity of FX. To investigate the molecular mechanisms of FX-induced apoptosis in PC12 after nanoencapsulation, proteomics analysis based on TMT technology was performed. Protein profiles in PC12 were determined after 0 (Control), 8 (L_Treat), and 24 (H_Treat) μg/mL nano-FX intervention. Results indicated 78 differential abundant proteins (DAPs) linked to the cytotoxicity of nano-FX could be potential biomarkers. GO and KEGG analysis revealed altered proteasome and NF-kappa B/MAPK/TNF. Proteins involved in cell proliferation were downregulated, while proteins response to autophagy and apoptosis were upregulated. The multiple mechanisms involved in the anti-tumor activity of nano-FX will provide a reference for the development of FX high value-added functional foods.
{"title":"Proteome analysis reveals the molecular mechanisms of fucoxanthin-induced apoptosis in glial cells PC12 after nanoencapsulation","authors":"Chunyan Wang , Xinxin Ma , Yoshimasa Nakamura , Hang Qi","doi":"10.1016/j.jff.2025.106710","DOIUrl":"10.1016/j.jff.2025.106710","url":null,"abstract":"<div><div>Fucoxanthin (FX) is a natural pigment belonging to the xanthophyll carotenoid, which has been proven to have inhibitory effects on glioblastoma. In our previous study, nano-FX was fabricated through whey protein and flaxseed gum co-encapsulated for improved stability and glial cell (PC12) inhibitory activity of FX. To investigate the molecular mechanisms of FX-induced apoptosis in PC12 after nanoencapsulation, proteomics analysis based on TMT technology was performed. Protein profiles in PC12 were determined after 0 (Control), 8 (L_Treat), and 24 (H_Treat) μg/mL nano-FX intervention. Results indicated 78 differential abundant proteins (DAPs) linked to the cytotoxicity of nano-FX could be potential biomarkers. GO and KEGG analysis revealed altered proteasome and NF-kappa B/MAPK/TNF. Proteins involved in cell proliferation were downregulated, while proteins response to autophagy and apoptosis were upregulated. The multiple mechanisms involved in the anti-tumor activity of nano-FX will provide a reference for the development of FX high value-added functional foods.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106710"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.jff.2025.106703
Hwa-Young Lee , Yun-Jo So , Geum-Hwa Lee , Gi-Hyun Jang , Do-Hyeon Kim , Myoung Ja Chung , Hyewon Lee , Yu-Mi Kim , Han-Jung Chae
Inhaling particulate matter (PM10) poses a serious global health risk, contributing to respiratory issues like inflammation, oxidative stress, and lung toxicity. Given the lack of effective treatments for PM10-induced lung injury, this study investigates the protective effect of curcumin-loaded nano-liposome, focusing on its potential molecular mechanisms. Mice exposed to PM10 were treated with curcumin-loaded nano-liposome over 14 days, revealing reduced inflammatory responses in lung tissue and bronchoalveolar lavage fluid (BALF). Curcumin-loaded nano-liposome decreased oxidative stress and ferroptosis markers, including ROS, MDA, and ACSL4, while increasing GPX4 levels. It also suppressed pyroptosis by reducing NLRP3 and pro-inflammatory cytokines, attenuated NF-κB signaling, and activated antioxidant pathways via Nrf2. These findings suggest curcumin-loaded nano-liposome as a potential therapeutic option for PM-induced respiratory disorders.
{"title":"Curcumin-loaded Nanoliposomes mitigate PM10-induced lung injury by modulating Inflammasome-mediated Pyroptosis","authors":"Hwa-Young Lee , Yun-Jo So , Geum-Hwa Lee , Gi-Hyun Jang , Do-Hyeon Kim , Myoung Ja Chung , Hyewon Lee , Yu-Mi Kim , Han-Jung Chae","doi":"10.1016/j.jff.2025.106703","DOIUrl":"10.1016/j.jff.2025.106703","url":null,"abstract":"<div><div>Inhaling particulate matter (PM10) poses a serious global health risk, contributing to respiratory issues like inflammation, oxidative stress, and lung toxicity. Given the lack of effective treatments for PM10-induced lung injury, this study investigates the protective effect of curcumin-loaded nano-liposome, focusing on its potential molecular mechanisms. Mice exposed to PM10 were treated with curcumin-loaded nano-liposome over 14 days, revealing reduced inflammatory responses in lung tissue and bronchoalveolar lavage fluid (BALF). Curcumin-loaded nano-liposome decreased oxidative stress and ferroptosis markers, including ROS, MDA, and ACSL4, while increasing GPX4 levels. It also suppressed pyroptosis by reducing NLRP3 and pro-inflammatory cytokines, attenuated NF-κB signaling, and activated antioxidant pathways via Nrf2. These findings suggest curcumin-loaded nano-liposome as a potential therapeutic option for PM-induced respiratory disorders.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106703"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-26DOI: 10.1016/j.jff.2025.106709
Jinyan Li , Jialan Zhang , Tong Gu , Li Li , Mengxiang Gao
A fungal immunomodulatory protein (FIP) (MeIMP) was discovered in edible mushroom Morchella eximia. Bioinformatics analysis demonstrated that MeIMP possesses cerato-platanin domains. Phylogenetic analysis positioned MeIMP within a distinct branch of the FIP family. The MeIMP gene was cloned and expressed in the Rosetta (DE3) strain. The anti-aging effect of recombinant MeIMP (rMeIMP) was evaluated by several indicators of Caenorhabditis elegans (C. elegans). The results indicated that rMeIMP significantly prolonged the lifespan of C. elegans, enhanced their motility ability, and diminished lipofuscin accumulation, while not affecting reproductive ability. Under UV, high temperature, and hydrogen peroxide stress, rMeIMP also significantly prolonged survival times of C. elegans. Additionally, rMeIMP extended the lifespan of C. elegans by scavenging ROS to mitigate the detrimental effects of oxidative stress. The establishment of a prokaryotic expression system for MeIMP and the assessment of rMeIMP function provided valuable insights for the further development and utilization of MeIMP.
{"title":"Anti-aging effect of recombinant Morchella eximia immunomodulatory protein on Caenorhabditis elegans","authors":"Jinyan Li , Jialan Zhang , Tong Gu , Li Li , Mengxiang Gao","doi":"10.1016/j.jff.2025.106709","DOIUrl":"10.1016/j.jff.2025.106709","url":null,"abstract":"<div><div>A fungal immunomodulatory protein (FIP) (MeIMP) was discovered in edible mushroom <em>Morchella eximia</em>. Bioinformatics analysis demonstrated that MeIMP possesses cerato-platanin domains. Phylogenetic analysis positioned MeIMP within a distinct branch of the FIP family. The <em>MeIMP</em> gene was cloned and expressed in the <em>Rosetta</em> (DE3) strain. The anti-aging effect of recombinant MeIMP (rMeIMP) was evaluated by several indicators of <em>Caenorhabditis elegans</em> (<em>C. elegans</em>). The results indicated that rMeIMP significantly prolonged the lifespan of <em>C. elegans</em>, enhanced their motility ability, and diminished lipofuscin accumulation, while not affecting reproductive ability. Under UV, high temperature, and hydrogen peroxide stress, rMeIMP also significantly prolonged survival times of <em>C. elegans</em>. Additionally, rMeIMP extended the lifespan of <em>C. elegans</em> by scavenging ROS to mitigate the detrimental effects of oxidative stress. The establishment of a prokaryotic expression system for MeIMP and the assessment of rMeIMP function provided valuable insights for the further development and utilization of MeIMP.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106709"},"PeriodicalIF":3.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-25DOI: 10.1016/j.jff.2025.106705
Oumayma Aguerd , Hamza Elhrech , Meryem El Fessikh , Khan Wen Goh , Nasreddine El Omari , Tarik Aanniz , Abdelhakim Bouyahya
Diabetes mellitus (DM) is a prevalent, long-term illness that adversely impacts patients' quality of life and significantly increases the risk of severe complications. Type 2 diabetes mellitus (T2DM) accounts for approximately 90 % of global diabetes cases and is influenced by lifestyle and epigenetic factors, including dietary habits and physical inactivity. Current primary treatments involve lifestyle changes and synthetic medications, which, despite their efficacy, can result in adverse side effects and high costs. In response, there is growing interest in plant-derived bioactive compounds as alternative therapeutic options for T2DM, given their accessibility, lower cost, and reduced risk of side effects. This review comprehensively explores the pharmacological actions of natural compounds against key molecular targets implicated in T2DM pathology, such as dipeptidyl peptidase-4 (DPP4), α-amylase, α-glucosidase, peroxisome proliferator-activated receptor γ (PPARγ), protein tyrosine phosphatase-1B (PTP1B), and glucose transporter type-4 (GLUT4), along with their roles in mitigating lipotoxicity and glucotoxicity. These findings underscore the potential of bioactive compounds in developing safer and more effective T2DM management strategies, paving the way for further research and clinical trials.
{"title":"Dietary bioactive compounds for type 2 diabetes: A comprehensive review of molecular interactions and mechanistic insights","authors":"Oumayma Aguerd , Hamza Elhrech , Meryem El Fessikh , Khan Wen Goh , Nasreddine El Omari , Tarik Aanniz , Abdelhakim Bouyahya","doi":"10.1016/j.jff.2025.106705","DOIUrl":"10.1016/j.jff.2025.106705","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a prevalent, long-term illness that adversely impacts patients' quality of life and significantly increases the risk of severe complications. Type 2 diabetes mellitus (T2DM) accounts for approximately 90 % of global diabetes cases and is influenced by lifestyle and epigenetic factors, including dietary habits and physical inactivity. Current primary treatments involve lifestyle changes and synthetic medications, which, despite their efficacy, can result in adverse side effects and high costs. In response, there is growing interest in plant-derived bioactive compounds as alternative therapeutic options for T2DM, given their accessibility, lower cost, and reduced risk of side effects. This review comprehensively explores the pharmacological actions of natural compounds against key molecular targets implicated in T2DM pathology, such as dipeptidyl peptidase-4 (DPP4), α-amylase, α-glucosidase, peroxisome proliferator-activated receptor γ (PPARγ), protein tyrosine phosphatase-1B (PTP1B), and glucose transporter type-4 (GLUT4), along with their roles in mitigating lipotoxicity and glucotoxicity. These findings underscore the potential of bioactive compounds in developing safer and more effective T2DM management strategies, paving the way for further research and clinical trials.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106705"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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