Journal of Functional Foods最新文献

{"title":"Unveiling the benefit of germinated colored rice extract to decrease metastatic potential of colorectal cancer cells","authors":"Kittirat Saharat ,&nbsp;Natthaphorn Paramee ,&nbsp;N. Monique Paricharttanakul ,&nbsp;Nuchanart Rangkadilok ,&nbsp;Daranee Chokchaichamnankit ,&nbsp;Chantragan Srisomsap ,&nbsp;Kriengsak Lirdprapamongkol ,&nbsp;Jisnuson Svasti ,&nbsp;Jutamaad Satayavivad","doi":"10.1016/j.jff.2024.106655","DOIUrl":"10.1016/j.jff.2024.106655","url":null,"abstract":"<div><div>There is increasing evidence of the health effects of germinated colored rice (GCR). Metastasis, namely the spread of cancer cells to distant sites in the body, is a serious problem for cancer therapy. This study aimed to explore the anti-metastatic potential of GCR extract in HT29 colorectal cancer cells through cell migration inhibition, and to identify target proteins by using proteomic approach. GCR extract at 4 mg/mL caused 87 % reduction in cell migration. Two-dimensional gel proteomic analysis revealed β-actin downregulation in GCR-treated cells. GCR also affected gene expression of actin dynamic regulatory proteins including <em>RHOA</em>, <em>RAC1</em>, and <em>CDC42</em> genes. Gamma-aminobutyric acid (GABA), a bioactive compound present in GCR extract, could decrease cell migration and downregulated β-actin in the cells, but did not alter expression level of <em>RHOA</em>, <em>RAC1</em>, and <em>CDC42</em> genes. This study reveals a potential of GCR to be developed as a functional food for assisting the cancer treatment.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106655"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats","authors":"Masatoshi Kubota ,&nbsp;Shogo Sugaki ,&nbsp;Erika Komori ,&nbsp;Reiko Watanabe ,&nbsp;Yuki Higuchi ,&nbsp;Yukikazu Harada ,&nbsp;Hiroyuki Hashimoto ,&nbsp;Shinobu Fujimura ,&nbsp;Motoni Kadowaki","doi":"10.1016/j.jff.2024.106647","DOIUrl":"10.1016/j.jff.2024.106647","url":null,"abstract":"<div><div>We investigated whether rice protein ameliorates the osteoporosis associated with type 2 diabetes in Zucker diabetic fatty rats. Diets containing rice endosperm protein, rice bran protein, or casein were fed for 10 weeks. The rats exhibited an early stage of diabetic nephropathy and chronic kidney disease–mineral and bone disorder, and parameters reflecting mineral and bone metabolism and bone structure and strength were evaluated. Feeding casein to Zucker Diabetic Fatty rats increased their serum fibroblast growth factor 23 and parathyroid hormone concentrations, suggesting relative excess phosphorus intake, a low serum osteocalcin concentration, and a slightly elevated serum tartrate-resistant acid phosphatase-5b concentration, indicating bone catabolism. In addition, the microarchitecture and strength of the femur were impaired. However, feeding rice endosperm protein and rice bran protein improved these parameters to near normal. These results imply that feeding these rice proteins causes an amelioration of diabetic osteoporosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106647"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating network analysis and experimental validation to reveal the mechanism of Cuscuta chinensis lam. Extract in the treatment of IgA nephropathy","authors":"Xianlong Zhang ,&nbsp;Mingjie Liang ,&nbsp;Ziyang Lin ,&nbsp;Minyi Li ,&nbsp;Tingting Duan ,&nbsp;Yun Han ,&nbsp;Lanqing Meng ,&nbsp;Mengqiu Li ,&nbsp;Guixuan Lin ,&nbsp;Tao Xia ,&nbsp;Ying Lai ,&nbsp;Boen Liang ,&nbsp;Bingqiong Li ,&nbsp;Minhua Li ,&nbsp;Fengxin Kang ,&nbsp;Quan Zhu ,&nbsp;Zhenghai Li ,&nbsp;Junzheng Yang","doi":"10.1016/j.jff.2024.106658","DOIUrl":"10.1016/j.jff.2024.106658","url":null,"abstract":"<div><h3>Purpose/aim</h3><div>IgA nephropathy represents a prevalent form of the common kidney disease globally, accounting for the majority of cases of chronic kidney disease and renal failure. <em>Cuscuta chinensis Lam</em> has been shown to nourish the liver and tonify the kidney, consolidate essence, and arrest polyuria, However, whether <em>Cuscuta chinensis Lam</em> has the protective effects on IgA nephropathy and the underlying mechanisms remain unclear.</div></div><div><h3>Methods</h3><div>A network pharmacology analysis was employed to examine the interactions between the active ingredients and core targets, with a view to elucidating the possible potential mechanisms in <em>Cuscuta chinensis Lam.</em> extract (CCLE) in the treatment of IgA nephropathy. Sprague-Dawley rats were administered with bovine serum albumin (BSA) with a dose of 800 mg/kg⁻¹ every other day for a period of 12 weeks to obtain IgA nephropathy model. lipopolysaccharide (LPS) was injected through the tail vein at a dose of 0.05 mg at the 6th week, 8th week, and 10th week; 0.1 mL of CCl₄ and 0.3 mL of castor oil were injected subcutaneously once a week for 12 weeks; the rats were gavaged with CCLE for 6 weeks from 13th week. Biochemical analysis, tGFR analysis, enzyme-linked immunosorbent assay (ELISA) analysis, periodic acid-Schiff (PAS) staining, Masson staining, and immunofluorescence staining were employed to evaluate the impact of CCLE on IgA nephropathy in rat. Western blotting was utilized to investigate the underlying mechanisms.</div></div><div><h3>Results</h3><div>The results demonstrated that a significant decrease in the glomerular filtration rate, accompanied by a notable elevation in biochemical indexes in rats in model group, including the ratio of total protein to creatinine in urine, sCr, BUN, TG, AST, ALT, IL-1β and TNF-α; additionally, the rats in the model group exhibited substantial histopathological alterations, characterized by the presence of many IgA deposits; CCLE has been demonstrated to enhance the glomerular filtration rate, downregulate the levels of sCr, BUN, TG, AST, ALT, IL-1β and TNF-α, reduce the IgA deposition, and ameliorate the histopathological changes in IgA nephropathy rats; Western blotting demonstrated CCLE can suppress the expressions of p-PI3K, p-AKT, p-IKK, p-NF-κB, and p-IκB in IgA nephropathy rats.</div></div><div><h3>Conclusion</h3><div>CCLE demonstrated superior protective effects on BSA + LPS + CCl₄ + castor oil-induced IgA nephropathy in rats by regulating the PI3K-AKT and NF-κB signaling pathways. These findings suggest that CCLE has potential as a therapeutic agent for the treatment of IgA nephropathy.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106658"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edible plant Artemisia argyi H.Lév. & Vaniot: An in vitro study on its anti-Helicobacter pylori effect","authors":"Meiyun Chen ,&nbsp;Sheng Pan ,&nbsp;Fengli Lin ,&nbsp;Weixing Zhu ,&nbsp;Baojie Li ,&nbsp;Bing Zhou ,&nbsp;Guimin Zhang ,&nbsp;Zhong Feng ,&nbsp;Meicun Yao","doi":"10.1016/j.jff.2024.106648","DOIUrl":"10.1016/j.jff.2024.106648","url":null,"abstract":"<div><div><em>A. argyi</em> is a renowned herb widely used in food and medicine, offering significant economic benefits. <em>H. pylori</em>, a known carcinogen, is associated with numerous diseases. Current treatments primarily rely on antibiotics, but rising resistance has reduced their efficacy. The activity and mechanisms of <em>A. argyi</em> against <em>H. pylori</em> infection remain unclear. <em>A. argyi</em> exhibited strong bacteriostatic and bactericidal effects against multiple <em>H. pylori</em>. It demonstrated no antagonistic effects when combined with antibiotics and disrupted <em>H. pylori</em> morphology and structure, downregulated various virulence genes, and inhibited urease activity. In co-culture systems, <em>A. argyi</em> reduced <em>H. pylori</em> adhesion, urease levels, and NO production, indicating immunomodulatory activity. Among the five components of <em>A. argyi</em> with anti-<em>H. pylori</em> activity, jaceosidin exhibited the strongest effect (MIC: 10 μg/mL), followed by eupatilin. Methylation of jaceosidin reduced its anti-<em>H. pylori</em> activity. <em>A. argyi</em> is an edible herb with anti- <em>H. pylori</em> activity and excellent safety.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106648"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice","authors":"Lu Xiu ,&nbsp;Rongguang Ge ,&nbsp;Siyu Lu ,&nbsp;Linwei Li ,&nbsp;Wenqi Huang ,&nbsp;Guojun Du ,&nbsp;Zengli Zhang ,&nbsp;Jie Zhang ,&nbsp;Zhongxiao Wan ,&nbsp;Jie Chang","doi":"10.1016/j.jff.2024.106649","DOIUrl":"10.1016/j.jff.2024.106649","url":null,"abstract":"<div><div>Diabetes, a ruthless chronic metabolic disorder, is increasingly considered to jeopardize global well-being over the decades. Royal jelly (RJ) is a complex natural product secreted by worker bees containing a unique fatty acid known as 10-hydroxy-2-decenoic acid (10-HDA). This study aimed to verify the protective effect on cognitive function of RJ and 10-HDA in diabetic mice and explore the underlying mechanism. Briefly, our animal experiment results suggested that 10-HDA had a significant hypoglycemic effect and improved cognitive performance. Through western blotting, RJ and 10-HDA intervention notably increased Atg7, Atg16L1, Beclin-1, Atg5, Atg12, Atg3, and LC3-II expression and decreased p62 expression. Meanwhile, decreased mTOR expression and increased ULK1 expression were also observed in the 10-HDA intervention group. In conclusion, 10-HDA can regulate mTOR/ULK1 pathway to activate autophagy to alleviate hippocampal damage, thereby improving cognitive function in mice with diabetes, which may provide a new option for real-world cognitive impairment management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106649"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition","authors":"Jiwen Li ,&nbsp;Zhongyu Li ,&nbsp;Mengru Cui ,&nbsp;Mei Sun ,&nbsp;Lei Men ,&nbsp;Xiaojie Gong ,&nbsp;Keke Li","doi":"10.1016/j.jff.2024.106646","DOIUrl":"10.1016/j.jff.2024.106646","url":null,"abstract":"<div><div>In this study, Drimartol B, a sesquiterpene coumarin isolated from the edible powder of <em>Artemisia sphaerocephala</em> seeds, was investigated for its potential anti-NSCLC effects. Our findings showed that drimartol B inhibited the proliferation of both A549 and NCI-H1975 cells. Mechanistic studies revealed that Drimartol B induced cell cycle arrest, decreased mitochondrial membrane potential, reduced Bcl-2, and increased Bax, Caspase-9, and -3 levels, thereby promoting apoptosis. Additionally, network pharmacology identified the PI3K/AKT/FoxO3a pathway as a key target. Molecular docking demonstrated favorable binding affinities between drimartol B and these proteins. Moreover, the regulatory role of drimartol B in NSCLC cells via PI3K/AKT/FoxO3a pathway was confirmed by co-treatment with SC-79 or JY-2. Overall, our findings reveal that drimartol B exerts anticancer effects on NSCLC cells via modulation of the PI3K/AKT/FoxO3a pathway. The future perspective of drimartol B as a dietary component for NSCLC treatment suggests its possible utility in personalized nutrition approaches.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106646"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity","authors":"Parichehr Amiri ,&nbsp;Seyed Ahmad Hosseini ,&nbsp;Maryam Saghafi-Asl ,&nbsp;Amin Akbari-Naserkiadeh ,&nbsp;Seyedeh Asal Jenani Zavieh ,&nbsp;Sara Arefhosseini ,&nbsp;Samira Asghari ,&nbsp;Neda Roshanravan","doi":"10.1016/j.jff.2024.106645","DOIUrl":"10.1016/j.jff.2024.106645","url":null,"abstract":"<div><div>Nowadays, the overwhelmed global prevalence of obesity has been emerged as the main cause of chronic non-communicable diseases. Microbiome-derived short-chain fatty acids, particularly sodium butyrate (NaBu) has been presented a plethora of pharmacological features in the treatment of metabolic conditions. The present triple-blind, randomized clinical trial examined the effects of NaBu supplementation on the expression of lipid metabolism- related genes in peripheral blood mononuclear cells, body composition compartments and serum high-sensitivity C-reactive protein (hs-CRP) in subjects with obesity. Fifty obese subjects were randomly allocated into either NaBu (600 mg/day) or placebo (carboxymethyl cellulose 600 mg/day) group along with hypocaloric diet for 8 weeks. At the end of the trial, the mRNA expression levels of adiponectin receptor-1, adiponectin receptor-2 and uncoupling protein-3, significantly increased in NaBu group to almost two-fold higher levels, compared with placebo group (<em>p</em> = 0.030, p = 0.030 and <em>p</em> = 0.010, respectively). Moreover, body composition compartments improved significantly in NaBu arm, in terms of reductions in fat mass (<em>p</em> = 0.027) and visceral fat (<em>p</em> = 0.026) as well as increases in fat-free mass (<em>p</em> = 0.032). Serum hs-CRP levels markedly decreased in NaBu group, while inter-group differences were non-significant. Taken together, NaBu supplementation could exert favorable anti-obesity effects through molecular pathways, while further research is recommended.</div><div>This study was registered in Iranian Registry of Clinical Trials (<span><span>https://irct.behdasht.gov.ir/user/trial/56967/view</span><svg><path></path></svg></span>), (IRCT20190303042905N3).</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106645"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro gastrointestinal digestion and colonic fermentation of Mangiferin: Impacts on gut microbiota and metabolite profiles","authors":"Huilin Deng ,&nbsp;Yaozhong Zheng ,&nbsp;Qiongyao Wang ,&nbsp;Jiaqi Peng ,&nbsp;Weibin Bai ,&nbsp;Lingmin Tian ,&nbsp;Zouyan He ,&nbsp;Rui Jiao","doi":"10.1016/j.jff.2025.106667","DOIUrl":"10.1016/j.jff.2025.106667","url":null,"abstract":"<div><div>Mangiferin (MGF), a C-glycosyl xanthone from the mango plant, offers various health benefits but has low absorption, mostly remaining in the gut where it interacts with microbes. This study examines MGF's effects on human gut microbiota and metabolite profiles after <em>in vitro</em> digestion and fermentation with feces. Findings indicate MGF had limited permeability (under 2 %) across the Caco-2 monolayer, with most being fermented by microbes. MGF utilization increased post-digestion and fermentation, significantly altering gut metabolite profiles by boosting lipid and benzenoid abundance while reducing organic acids. It also promoted beneficial bacteria like <em>Bacteroides</em> and <em>Bifidobacterium</em>, decreasing harmful genera such as <em>Sutterella</em>. Metabolomic analysis revealed enhanced pathways for unsaturated fatty acid synthesis and longevity, primarily through oleic and linolenic acids, highlighting MGF's role in modulating gut health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106667"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of diet and lifestyle with new-onset diabetes and major cardiovascular events: The cardiometabolic disease and cancer cohort (4C) study and mendelian randomization","authors":"Yue-Yang Zhang ,&nbsp;Pei-Dong Li ,&nbsp;Bing-Xue Chen ,&nbsp;Qin Wan","doi":"10.1016/j.jff.2024.106614","DOIUrl":"10.1016/j.jff.2024.106614","url":null,"abstract":"<div><h3>Background and Aim</h3><div>At present, there is an absence of a widely accepted model for a healthy diet-lifestyle in China. Therefore, this study aims to provide novel evidence for the development of a healthier diet-lifestyle model specifically tailored to the Chinese population.</div></div><div><h3>Methods and Results</h3><div>Over the 10-year follow-up period of 7612 participants, 545 incident cases of diabetes and 308 incident cases of major cardiovascular events were documented. Cox regression analysis indicated that participants consuming 0–2 servings of milk per week had a reduced risk of diabetes, with a hazard ratio of 0.72 (0.56–0.92). In contrast, coffee consumption was associated with an increased risk of diabetes. Moderate consumption of carbonated drinks and fruit drink was linked to a decreased risk of major cardiovascular events. The RCS analysis and Mendelian randomization analysis yielded largely consistent results.</div></div><div><h3>Conclusions</h3><div>These research findings underscore the crucial role of maintaining appropriate dietary and lifestyle habits for overall health in adults.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106614"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary secoisolariciresinol diglucoside ameliorates high-fat diet-induced atherosclerosis via regulating immunological inflammation and reshaping gut microbiota in ApoE-/- mice","authors":"Yiwei Li ,&nbsp;Jing Wang ,&nbsp;Jian Liu ,&nbsp;Ting Wang ,&nbsp;Yuanyuan Liu ,&nbsp;Yajuan Liu ,&nbsp;Li Guo ,&nbsp;Zhixia Bai ,&nbsp;Wenke Shen ,&nbsp;Ru Yan ,&nbsp;Huiyan Ma ,&nbsp;Juan Liu ,&nbsp;Hao Wang ,&nbsp;Xiaoxia Zhang","doi":"10.1016/j.jff.2024.106642","DOIUrl":"10.1016/j.jff.2024.106642","url":null,"abstract":"<div><div>Secoisolariciresinol diglucoside (SDG) has shown a variety of biological activities, but its impact on atherosclerosis (AS) remains poorly understood. This study investigated the potential of SDG in preventing and treating AS. Firstly, SDG administration ameliorated atherosclerotic lesion, lipid indicators and total bile acids (TBA). It also reduced chronic systemic/vascular inflammatory cytokines and in situ macrophages (Mψs). Due to the critical role of gut-vascular axis in AS, multi-omics analysis revealed that the modulation of gut microbiota and metabolism, including reductions in <em>Firmicutes</em>, <em>Intestinimonas</em>, <em>Bilophila</em>, <em>Oscillibacter</em> and <em>Negativibacillus</em> and increases in linoleic acid and 12,13-DHOME, may contribute to the attenuation of SDG on gut dysbiosis. Further verification exhibited that the regulation of intestinal gammadelta and regulatory T subsets, incresed intestinal tight junction proteins and lower plasma lipopolysaccharide (LPS) may attributed to this effectiveness of SDG intervenion. Collectively, dietary SDG ameliorates HFD-induced AS mice via suppressing inflammation and reshaping gut homeostasis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106642"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}