Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106670
Jian Liu , Yiwei Li , Wenke Shen , Ting Wang , Yuanyuan Liu , Junbai Ma , Xiaoxu Zhang , Ting Li , Wenyan Tian , Xiaolong Ma , Lina Zhang , Ke Li , Ming Li , Xiaoxia Zhang , Qing Liu , Hao Wang
{"title":"Corrigendum to “Dietary supplementation of α-linolenic acid-rich flaxseed oil enhances anti-PD-1 protection against orthotopic hepatocellular carcinoma by reshaping gut homeostasis and improving anti-tumor immunity via gut-liver axis in mice” [J. Funct. Foods 116 (2024) 106157]","authors":"Jian Liu , Yiwei Li , Wenke Shen , Ting Wang , Yuanyuan Liu , Junbai Ma , Xiaoxu Zhang , Ting Li , Wenyan Tian , Xiaolong Ma , Lina Zhang , Ke Li , Ming Li , Xiaoxia Zhang , Qing Liu , Hao Wang","doi":"10.1016/j.jff.2025.106670","DOIUrl":"10.1016/j.jff.2025.106670","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106670"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143347853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106685
Jing Sui , Wenbin Shen , Yanni Zhang , Jiarui Liang , Hui Xia , Guiju Sun
Aim of the current study was to clarify the association of carotenoid consumption and chronic obstructive pulmonary disease (COPD) through a meta-analysis of observational studies. We searched the online databases up to August 15, 2024. Both observational studies conducted in human populations were included, and association between level of carotenoids intake/blood and COPD. We performed a meta-analysis using random-effects models. Seven of 9723 records were included in the present study. The odds ratio (OR) between carotenoids consumption and COPD risk was 0.69 (95 % CI: 0.59–0.80, p < 0.001), which indicates a significant protective effect. In addition, subgroup analysis revealed that the various types of carotenoids including a-carotene, β-carotene and cryptoxanthin were significant in COPD (OR = 0.51, 95 % CI: 0.37–0.69; OR = 0.72, 95 % CI: 0.57–0.92; OR = 0.51, 95 % CI: 0.38–0.69, separately). Conclusion: Carotenoids consumption has a protective effect on the risk of COPD.
{"title":"The protective role of carotenoids in chronic obstructive pulmonary disease: A systematic review and Meta-analysis of observational studies","authors":"Jing Sui , Wenbin Shen , Yanni Zhang , Jiarui Liang , Hui Xia , Guiju Sun","doi":"10.1016/j.jff.2025.106685","DOIUrl":"10.1016/j.jff.2025.106685","url":null,"abstract":"<div><div>Aim of the current study was to clarify the association of carotenoid consumption and chronic obstructive pulmonary disease (COPD) through a meta-analysis of observational studies. We searched the online databases up to August 15, 2024. Both observational studies conducted in human populations were included, and association between level of carotenoids intake/blood and COPD. We performed a meta-analysis using random-effects models. Seven of 9723 records were included in the present study. The odds ratio (OR) between carotenoids consumption and COPD risk was 0.69 (95 % CI: 0.59–0.80, <em>p</em> < 0.001), which indicates a significant protective effect. In addition, subgroup analysis revealed that the various types of carotenoids including a-carotene, β-carotene and cryptoxanthin were significant in COPD (OR = 0.51, 95 % CI: 0.37–0.69; OR = 0.72, 95 % CI: 0.57–0.92; OR = 0.51, 95 % CI: 0.38–0.69, separately). Conclusion: Carotenoids consumption has a protective effect on the risk of COPD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106685"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2024.106657
Lingchen Yang , Hongwei Ma
To investigate the effects of quercetin (Que) on the improvement of endometrial cancer (EC) and the relative associated mechanisms. Network pharmacology was used to analyze the correlation between Que. and EC. Ishikawa and HEC-1 A cell lines were used as research models in the present study. The cell lines were divided into the following groups: Normal, lentivirus (LV)-negative control (NC), Que., Que. + LV-activating transcription factor 5 (ATF5)-RNA interference (RNAi) and Que. + LV-ATF5-RNAi+mTOR agonist. Cell Counting Kit-8 and flow cytometry assays were used to evaluate cell proliferation and apoptosis; cell invasive and migratory abilities were assessed by Transwell and wound healing assays, respectively; the observation of the cell ultrastructure was performed by transmission electron microscopy; the relative protein expressions were measured by the western blot assay. Depending on results, Que. exhibited antitumor effects by stimulating autophagy via regulating the ATF5/JUN/PI3K/AKT/mTOR pathway in EC.
{"title":"Quercetin inhibits the biological activity of endometrial cancer by regulating autophagy: A network pharmacology analysis and cellular experimental validation","authors":"Lingchen Yang , Hongwei Ma","doi":"10.1016/j.jff.2024.106657","DOIUrl":"10.1016/j.jff.2024.106657","url":null,"abstract":"<div><div>To investigate the effects of quercetin (Que) on the improvement of endometrial cancer (EC) and the relative associated mechanisms. Network pharmacology was used to analyze the correlation between Que. and EC. Ishikawa and HEC-1 A cell lines were used as research models in the present study. The cell lines were divided into the following groups: Normal, lentivirus (LV)-negative control (NC), Que., Que. + LV-activating transcription factor 5 (ATF5)-RNA interference (RNAi) and Que. + LV-ATF5-RNAi+mTOR agonist. Cell Counting Kit-8 and flow cytometry assays were used to evaluate cell proliferation and apoptosis; cell invasive and migratory abilities were assessed by Transwell and wound healing assays, respectively; the observation of the cell ultrastructure was performed by transmission electron microscopy; the relative protein expressions were measured by the western blot assay. Depending on results, Que. exhibited antitumor effects by stimulating autophagy via regulating the ATF5/JUN/PI3K/AKT/mTOR pathway in EC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106657"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106675
Xingliang Xiang , Yukun Liu , Zhaoxiang Zeng , Xueyan Zhao , Qingxin Shi , Xing Huang , Haijun Yang , Chengwu Song , Shunqing Xu , Shuna Jin
Glucolipid metabolic disorder (GMD) is an urgent global public health problem. Fermented turmeric (FT) might be a functional food resource for prevention and treatment of GMD, but its effect and mechanism remain unclear. In this study, the activity of FT on GMD involving brown adipose tissue (BAT) was investigated. The results of animal experiment suggested that 4-week FT supplement comprehensively improved the characteristic symptoms of GMD, showing better therapeutic efficacy than crude turmeric. Due to activation of BAT in the process of treatment, transcriptome analysis was performed for the underlying mechanism based on BAT. As a result, butanoate metabolism signaling pathway was highlighted with regulating ACSM3 and HADH. Considering the poor absorption of curcuminoids, intestinal environment was analyzed for further exploring the upstream signal of short-chain fatty acids (SCFAs) metabolism. And FT reversed intestinal dysbiosis and enriched SCFAs producing bacteria, including Bacteroides, Odoribacter, Parvibacter and un_Muribaculaceae. Simultaneously, the production and absorption of three SCFAs had been upregulated. Increasing SCFAs could play a crucial role in stimulating butanoate metabolism of BAT to improve GMD, especially butyric acid. Consequently, the SCFAs mediating crosstalk between microbiota and BAT could contribute to anti-GMD activity. Our study demonstrated the great potential of FT for prevention and treatment of GMD, and provided a basis for its further application and development.
{"title":"Exploration of the mechanism of fermented turmeric preventing glucolipid metabolic disorder: Insights into signaling of microbiota-SCFAs-brown adipose tissue axis in mice","authors":"Xingliang Xiang , Yukun Liu , Zhaoxiang Zeng , Xueyan Zhao , Qingxin Shi , Xing Huang , Haijun Yang , Chengwu Song , Shunqing Xu , Shuna Jin","doi":"10.1016/j.jff.2025.106675","DOIUrl":"10.1016/j.jff.2025.106675","url":null,"abstract":"<div><div>Glucolipid metabolic disorder (GMD) is an urgent global public health problem. Fermented turmeric (FT) might be a functional food resource for prevention and treatment of GMD, but its effect and mechanism remain unclear. In this study, the activity of FT on GMD involving brown adipose tissue (BAT) was investigated. The results of animal experiment suggested that 4-week FT supplement comprehensively improved the characteristic symptoms of GMD, showing better therapeutic efficacy than crude turmeric. Due to activation of BAT in the process of treatment, transcriptome analysis was performed for the underlying mechanism based on BAT. As a result, butanoate metabolism signaling pathway was highlighted with regulating ACSM3 and HADH. Considering the poor absorption of curcuminoids, intestinal environment was analyzed for further exploring the upstream signal of short-chain fatty acids (SCFAs) metabolism. And FT reversed intestinal dysbiosis and enriched SCFAs producing bacteria, including <em>Bacteroides</em>, <em>Odoribacter</em>, <em>Parvibacter</em> and <em>un_Muribaculaceae</em>. Simultaneously, the production and absorption of three SCFAs had been upregulated. Increasing SCFAs could play a crucial role in stimulating butanoate metabolism of BAT to improve GMD, especially butyric acid. Consequently, the SCFAs mediating crosstalk between microbiota and BAT could contribute to anti-GMD activity. Our study demonstrated the great potential of FT for prevention and treatment of GMD, and provided a basis for its further application and development.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106675"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106661
Emily G. Knox , Paula Sánchez-Díaz , Colin Buttimer , Sarah-Jane Leigh , Klara Vlckova , Colin Hill , Elaine Kennedy , Jonathan O’Regan , Seamus McSweeney , David Goulding , Maria Rodriguez Aburto , Caitriona M. O’Driscoll , John F. Cryan , Eoin Gunnigle , Gerard Clarke
The gut and blood-brain barrier are essential components of the microbiota-gut-brain axis and are influenced by diet, particularly in infancy. Breast milk supports gut and brain barrier function, but infant formulas often lack key protective components. Bifidobacterium is the predominant bacteria in the infant gut microbiome. Here, we evaluated the impact of four infant formulas fermented with three Bifidobacterium strains, originally isolated from infant stool, on gut and BBB integrity. Cell-free supernatants from these fermentations were exposed to cultures of T84 colonocytes (gut barrier model) or bEnd.3 brain endothelial cells (BBB model), with and without lipopolysaccharide challenge. All three Bifidobacterium strains exhibited protective effects on both gut barrier and BBB integrity with a profile that depended on the infant formula. Taken together, this data indicates that the fermentation products of relevant Bifidobacterium strains with infant formulas may provide protection against barrier disruption.
{"title":"Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function","authors":"Emily G. Knox , Paula Sánchez-Díaz , Colin Buttimer , Sarah-Jane Leigh , Klara Vlckova , Colin Hill , Elaine Kennedy , Jonathan O’Regan , Seamus McSweeney , David Goulding , Maria Rodriguez Aburto , Caitriona M. O’Driscoll , John F. Cryan , Eoin Gunnigle , Gerard Clarke","doi":"10.1016/j.jff.2025.106661","DOIUrl":"10.1016/j.jff.2025.106661","url":null,"abstract":"<div><div>The gut and blood-brain barrier are essential components of the microbiota-gut-brain axis and are influenced by diet, particularly in infancy. Breast milk supports gut and brain barrier function, but infant formulas often lack key protective components. Bifidobacterium is the predominant bacteria in the infant gut microbiome. Here, we evaluated the impact of four infant formulas fermented with three Bifidobacterium strains, originally isolated from infant stool, on gut and BBB integrity. Cell-free supernatants from these fermentations were exposed to cultures of T84 colonocytes (gut barrier model) or bEnd.3 brain endothelial cells (BBB model), with and without lipopolysaccharide challenge. All three <em>Bifidobacterium</em> strains exhibited protective effects on both gut barrier and BBB integrity with a profile that depended on the infant formula. Taken together, this data indicates that the fermentation products of relevant <em>Bifidobacterium</em> strains with infant formulas may provide protection against barrier disruption.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106661"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106692
Xinyi Lv , Zijian Wu , Limin Wang , Peibo Guo , Ao Qu , Wenjing Liang , Pengbo Zheng , Yuan Li , Wen Zhang
Curcumin (Cur), a naturally occurring flavonoid compound, is known for its multiple health benefits. Nevertheless, its bioavailability is greatly restricted due to poor solubility and stability. In order to address this problem, phytic acid was used in a pH-driven method to create curcumin-loaded zein-shellac nanoparticles (Zein-SH-CurNPs). The results confirmed that the hydrophobic center of zein-shellac nanoparticles (Zein-SHNPs) effectively encapsulated curcumin, leading to the formation of spherical particles that exhibited an impressive encapsulation efficiency of 96.96 % and a loading capacity of 4.65 %. Curcumin-induced zein fluorescence quenching was found to be static using fluorescence spectroscopy. In vivo colitis experiments conducted on mice disclosed that Zein-SH-CurNP exhibits a protective effect against DSS-induced colitis. Notably, the levels of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), mouse interleukin-6 (IL-6), and interleukin-1β (IL-1β), were significantly reduced. To summarize, the results suggest that the zein-shellac composites hold potential as advanced nano-delivery structures for insoluble bioactive substances.
{"title":"The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect","authors":"Xinyi Lv , Zijian Wu , Limin Wang , Peibo Guo , Ao Qu , Wenjing Liang , Pengbo Zheng , Yuan Li , Wen Zhang","doi":"10.1016/j.jff.2025.106692","DOIUrl":"10.1016/j.jff.2025.106692","url":null,"abstract":"<div><div>Curcumin (Cur), a naturally occurring flavonoid compound, is known for its multiple health benefits. Nevertheless, its bioavailability is greatly restricted due to poor solubility and stability. In order to address this problem, phytic acid was used in a pH-driven method to create curcumin-loaded zein-shellac nanoparticles (Zein-SH-CurNPs). The results confirmed that the hydrophobic center of zein-shellac nanoparticles (Zein-SHNPs) effectively encapsulated curcumin, leading to the formation of spherical particles that exhibited an impressive encapsulation efficiency of 96.96 % and a loading capacity of 4.65 %. Curcumin-induced zein fluorescence quenching was found to be static using fluorescence spectroscopy. <em>In vivo</em> colitis experiments conducted on mice disclosed that Zein-SH-CurNP exhibits a protective effect against DSS-induced colitis. Notably, the levels of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), mouse interleukin-6 (IL-6), and interleukin-1β (IL-1β), were significantly reduced. To summarize, the results suggest that the zein-shellac composites hold potential as advanced nano-delivery structures for insoluble bioactive substances.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106692"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106671
Wei Wu , Jie Zhang , Zijiao Wang , Chuan Cheng , Dongdong Yuan , Li Peng , Le Li
A growing body of evidence indicates that tumor-associated macrophages (TAMs) are crucial contributors to cancer progression, positioning them as an attractive target for therapeutic intervention. In our previous studies, we found that Platycodon grandiflorum exert anti-melanoma effects by influencing TAMs. Platycodin D (PD), a bioactive compound derived from the dried roots of Platycodon grandiflorum, possesses anti-inflammatory, immunomodulatory, and anti-tumor properties. Based on this, we hypothesized that PD could have anti-melanoma potential and set out to investigate its molecular mechanisms in relation to TAMs. Treatment with PD led to a significant reduction in melanoma tumor weight, inhibition of the mTOR pathway, and suppression of M2-polarized macrophages. PD also downregulated M2 macrophage markers, impaired mitochondrial function, reduced ROS production, and diminished the tumor-promoting functions of TAMs. Through network pharmacology and experimental validation, STAT3 was identified as a central target. PD was shown to decrease JAK2 and p-STAT3 levels, promote JAK2 degradation, and enhance its ubiquitination. In Lyz2cre/cre JAK2flox/flox mice, which lack JAK2 specifically in bone marrow-derived macrophages (BMDMs) were resistant to PD's effects on M2 polarization, mitochondrial function, and melanoma suppression. In summary, PD inhibits melanoma growth by targeting JAK2, which in turn influences M2 polarization and mitochondrial function. This study underscores the potential of PD in regulating TAMs, providing new insights into its potential use in cancer therapy.
{"title":"Platycodin D inhibits tumor proliferation by modulating macrophage polarization through promoting JAK2 ubiquitination","authors":"Wei Wu , Jie Zhang , Zijiao Wang , Chuan Cheng , Dongdong Yuan , Li Peng , Le Li","doi":"10.1016/j.jff.2025.106671","DOIUrl":"10.1016/j.jff.2025.106671","url":null,"abstract":"<div><div>A growing body of evidence indicates that tumor-associated macrophages (TAMs) are crucial contributors to cancer progression, positioning them as an attractive target for therapeutic intervention. In our previous studies, we found that <em>Platycodon grandiflorum</em> exert anti-melanoma effects by influencing TAMs. Platycodin D (PD), a bioactive compound derived from the dried roots of <em>Platycodon grandiflorum</em>, possesses anti-inflammatory, immunomodulatory, and anti-tumor properties. Based on this, we hypothesized that PD could have anti-melanoma potential and set out to investigate its molecular mechanisms in relation to TAMs. Treatment with PD led to a significant reduction in melanoma tumor weight, inhibition of the mTOR pathway, and suppression of M2-polarized macrophages. PD also downregulated M2 macrophage markers, impaired mitochondrial function, reduced ROS production, and diminished the tumor-promoting functions of TAMs. Through network pharmacology and experimental validation, STAT3 was identified as a central target. PD was shown to decrease JAK2 and p-STAT3 levels, promote JAK2 degradation, and enhance its ubiquitination. In Lyz2<sup>cre/cre</sup> JAK2<sup>flox/flox</sup> mice, which lack JAK2 specifically in bone marrow-derived macrophages (BMDMs) were resistant to PD's effects on M2 polarization, mitochondrial function, and melanoma suppression. In summary, PD inhibits melanoma growth by targeting JAK2, which in turn influences M2 polarization and mitochondrial function. This study underscores the potential of PD in regulating TAMs, providing new insights into its potential use in cancer therapy.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106671"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106694
Taeuk Kim , Seungok Lee , Sein Lee , Hyejung Han , Chul-Hong Kim , Dong-Woo Lee , Jae-Kwan Hwang
Maintaining protein homeostasis is crucial to prevent muscle wasting caused by an imbalance between muscle protein synthesis and degradation. In this study, in vitro and in vivo experiments were performed using C2C12 myotubes and C57BL/6 mice treated with dexamethasone to investigate the anti-atrophic effects of Osmanthus fragrans water extract (OFWE). In C2C12 myotubes, OFWE improved the protein synthesis by upregulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin pathway and muscle differentiation by activating myogenesis-related genes. Moreover, OFWE treatment reduced muscle protein degradation by regulating the nuclear translocation of forkhead box O3a and the expression of E3 ubiquitin ligases. In an animal model, OFWE administration was shown to increase muscle mass, myofiber size, and exercise capacity. OFWE also activated the PI3K/Akt pathway and inhibited protein catabolism. In conclusion, OFWE exhibited beneficial effects on muscle atrophy both in vitro and in vivo.
{"title":"Fragrant olive (Osmanthus fragrans Lour.) flower extract attenuates dexamethasone-induced muscle atrophy through stimulation of PI3K/Akt pathway in C2C12 myotubes and C57BL/6 mice","authors":"Taeuk Kim , Seungok Lee , Sein Lee , Hyejung Han , Chul-Hong Kim , Dong-Woo Lee , Jae-Kwan Hwang","doi":"10.1016/j.jff.2025.106694","DOIUrl":"10.1016/j.jff.2025.106694","url":null,"abstract":"<div><div>Maintaining protein homeostasis is crucial to prevent muscle wasting caused by an imbalance between muscle protein synthesis and degradation. In this study, <em>in vitro</em> and <em>in vivo</em> experiments were performed using C2C12 myotubes and C57BL/6 mice treated with dexamethasone to investigate the anti-atrophic effects of <em>Osmanthus fragrans</em> water extract (OFWE). In C2C12 myotubes, OFWE improved the protein synthesis by upregulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin pathway and muscle differentiation by activating myogenesis-related genes. Moreover, OFWE treatment reduced muscle protein degradation by regulating the nuclear translocation of forkhead box O3a and the expression of E3 ubiquitin ligases. In an animal model, OFWE administration was shown to increase muscle mass, myofiber size, and exercise capacity. OFWE also activated the PI3K/Akt pathway and inhibited protein catabolism. In conclusion, OFWE exhibited beneficial effects on muscle atrophy both <em>in vitro</em> and <em>in vivo.</em></div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106694"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106680
Sizhu Ren , Chunyan Xie , Hua Liu , Liyan Li , Xiaoling Han , Wenjie Chen
The mycelia and fruiting bodies of Lentinula edodes are rich in polysaccharides that are widely studied for their edible and medicinal properties. Many advanced technologies have been applied for lentinan extraction, such as ultrasonic-assisted, microwave-assisted, and enzyme-assisted extractions. However, their advantages and disadvantages differ, which directly affect the structural and functional properties of lentinan. Compared with traditional methods, these advanced technologies have the advantages of high extraction efficiency, short operation time, low energy consumption, and low solvent consumption. Based on a summary of the extraction methods and biological functions of lentinan, this review article concentrates on the current literature on the extraction of lentinan, its chemical composition, and medicinal mechanisms. In addition, future research topics are also proposed.
{"title":"Recent advances in the extraction technology and bioactivity of lentinan","authors":"Sizhu Ren , Chunyan Xie , Hua Liu , Liyan Li , Xiaoling Han , Wenjie Chen","doi":"10.1016/j.jff.2025.106680","DOIUrl":"10.1016/j.jff.2025.106680","url":null,"abstract":"<div><div>The mycelia and fruiting bodies of <em>Lentinula edodes</em> are rich in polysaccharides that are widely studied for their edible and medicinal properties. Many advanced technologies have been applied for lentinan extraction, such as ultrasonic-assisted, microwave-assisted, and enzyme-assisted extractions. However, their advantages and disadvantages differ, which directly affect the structural and functional properties of lentinan. Compared with traditional methods, these advanced technologies have the advantages of high extraction efficiency, short operation time, low energy consumption, and low solvent consumption. Based on a summary of the extraction methods and biological functions of lentinan, this review article concentrates on the current literature on the extraction of lentinan, its chemical composition, and medicinal mechanisms. In addition, future research topics are also proposed.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"125 ","pages":"Article 106680"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.jff.2025.106673
Lingwei Yang , Zhonghua Liu , Ligui Xiong , Yushun Gong
Caenorhabditis elegans (C. elegans) has proven to be a valuable model organism for assessing active ingredients. The wide array of active compounds found in tea, including tea polyphenols, amino acids, alkaloids, and aromatic substances, has provided numerous health benefits. In C. elegans, active ingredients such as catechins and their derivatives, L-theanine, and caffeine have exhibited various biological effects, including slowing down aging, enhancing environmental adaptations, regulating protein homeostasis and glycolipid metabolism, and participating in immunomodulation. The worms play a crucial role in studying the mechanisms of tea polyphenols and exploring the bioactivity of catechin derivatives. Here, we discuss how these active ingredients promote worms' health, and elucidate their mechanisms of action. We further offer recommendations for utilizing nematodes and microorganisms as host-microbe models to combine multiple active tea components in the diet or to investigate the unique chemical components present in other teas, aiming to enhance our understanding of the health benefits of tea consumption on biological organisms.
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