Pub Date : 2024-11-01DOI: 10.1016/j.jff.2024.106559
Pei Wang , Chen Zhang , Da Pan , Hui Xia , Yuanyuan Wang , Junmao Sun , Tong Jiang , Guiju Sun , Jiazhang Huang
{"title":"Corrigendum to “The effects of alfalfa powder combined with health education on patients with dyslipidemia: A randomized controlled trial” [J. Funct. Foods 121 (2024) 106445]","authors":"Pei Wang , Chen Zhang , Da Pan , Hui Xia , Yuanyuan Wang , Junmao Sun , Tong Jiang , Guiju Sun , Jiazhang Huang","doi":"10.1016/j.jff.2024.106559","DOIUrl":"10.1016/j.jff.2024.106559","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106559"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jff.2024.106555
Heekuk Park , Jihye Baek , Se Young Park , Soonok Sa , Ji Eun Jun , Min Jeong Kim , In-Kyung Jeong , Wonyong Kim
D-allulose, a rare sugar recognized as Generally Recognized as Safe, has emerged as a potential alternative to sucrose. Despite its growing popularity, research on its effects on the human gut microbiota, including pathogens, remains scarce. To address these concerns, we conducted a 12-week randomized, double-blind, parallel, placebo-controlled study assessing D-allulose’s safety on gut microbiota in humans. Participants consumed 15 g/day of D-allulose or sucralose (placebo) for 12 weeks. Gut microbiota analysis in stool samples, performed through shotgun metagenomics sequencing before and after the intervention, evaluated microbial diversity, taxonomy of prevalent species, changes in pathogenic bacteria (Clostridium difficile, Helicobacter hepaticus, Klebsiella pneumoniae, Bacteroides fragilis, Staphylococcus aureus, and Salmonella enterica), and short-chain fatty acid production. Our findings revealed no significant differences in microbial diversity, pathogenic bacteria levels, or short-chain fatty acid production, suggesting that D-allulose consumption is safe and does not adversely affect the gut microbiome or pathogen presence.
{"title":"Impact of D-allulose consumption on Enteric pathogens in human gut Microbiota: A randomized controlled trial study","authors":"Heekuk Park , Jihye Baek , Se Young Park , Soonok Sa , Ji Eun Jun , Min Jeong Kim , In-Kyung Jeong , Wonyong Kim","doi":"10.1016/j.jff.2024.106555","DOIUrl":"10.1016/j.jff.2024.106555","url":null,"abstract":"<div><div>D-allulose, a rare sugar recognized as Generally Recognized as Safe, has emerged as a potential alternative to sucrose. Despite its growing popularity, research on its effects on the human gut microbiota, including pathogens, remains scarce. To address these concerns, we conducted a 12-week randomized, double-blind, parallel, placebo-controlled study assessing D-allulose’s safety on gut microbiota in humans. Participants consumed 15 g/day of D-allulose or sucralose (placebo) for 12 weeks. Gut microbiota analysis in stool samples, performed through shotgun metagenomics sequencing before and after the intervention, evaluated microbial diversity, taxonomy of prevalent species, changes in pathogenic bacteria (<em>Clostridium difficile, Helicobacter hepaticus, Klebsiella pneumoniae, Bacteroides fragilis, Staphylococcus aureus, and Salmonella enterica</em>), and short-chain fatty acid production. Our findings revealed no significant differences in microbial diversity, pathogenic bacteria levels, or short-chain fatty acid production, suggesting that D-allulose consumption is safe and does not adversely affect the gut microbiome or pathogen presence.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106555"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jff.2024.106554
Lu Liu , Yuanyuan Sun , Houxue Cui, Nanxi Dong, Dong Niu
Ferulic acid (FA) is a natural phenolic acid with a strong protective effect against disorder of hepatic lipid metabolism. To elucidate the effect of FA on metabolic associated fatty liver disease (MAFLD), the physiological parameters of mice fed high-fat diet (HFD) with or without FA were examined, and the liver transcriptome and metabolome were evaluated. FA significantly inhibited increases in liver weight and decreased the serum triglyceride levels and prevented HFD-induced hepatic steatosis. Omic data showed that FA might reduce the deposition of carnitine C16:1 to alleviate HFD-induced liver damage by reducing the expression of SOCS3 in vivo. Oleic acid induced steatosis in Hepa1-6 cells was used to verify the hepatoprotective effect of FA in vitro. Treatment with FA suppressed cellular lipid droplet deposition and decreased the expression of SOCS3 and adipogenesis markers. This work indicates the potential of FA as a novel drug for the alleviation of hepatic steatosis.
{"title":"New insights into the hepato-protective effects of ferulic acid based on transcriptomic and metabolomic profiling","authors":"Lu Liu , Yuanyuan Sun , Houxue Cui, Nanxi Dong, Dong Niu","doi":"10.1016/j.jff.2024.106554","DOIUrl":"10.1016/j.jff.2024.106554","url":null,"abstract":"<div><div>Ferulic acid (FA) is a natural phenolic acid with a strong protective effect against disorder of hepatic lipid metabolism. To elucidate the effect of FA on metabolic associated fatty liver disease (MAFLD), the physiological parameters of mice fed high-fat diet (HFD) with or without FA were examined, and the liver transcriptome and metabolome were evaluated. FA significantly inhibited increases in liver weight and decreased the serum triglyceride levels and prevented HFD-induced hepatic steatosis. Omic data showed that FA might reduce the deposition of carnitine C16:1 to alleviate HFD-induced liver damage by reducing the expression of <em>SOCS3 in vivo.</em> Oleic acid induced steatosis in Hepa1-6 cells was used to verify the hepatoprotective effect of FA <em>in vitro</em>. Treatment with FA suppressed cellular lipid droplet deposition and decreased the expression of <em>SOCS3</em> and adipogenesis markers. This work indicates the potential of FA as a novel drug for the alleviation of hepatic steatosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106554"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intestinal tight junction disruption initiates pathogenesis of colitis and determines diseases progression. At present, there is no therapeutics that directly corrects intestinal tight junction disassembly. Here, we discovered that Ocimum sanctum L. flower aqueous extract (OSLF) and gallic acid, increased intestinal barrier function by suppressing tight junction-dependent leak pathway permeability after being disrupted by Ca2+ depletion method. Transepithelial electrical resistance (TER) measurement, western blot analysis, immunofluorescence staining, and molecular docking indicated that OSLF and gallic acid improved intestinal barrier function by inducing tight junction assembly and inhibiting leak pathway permeability in intestinal epithelial cell monolayers via CaMKK-β/AMPK/SIRT-1/ERK-dependent fashion. Therefore, Gallic acid represents a drug candidate for treating diseases associated impaired intestinal barrier function including colitis.
{"title":"Enhancing intestinal tight junction assembly by gallic acid as a subcellular basis for the pharmacological effect of Ocimum sanctum L. flower aqueous extract","authors":"Wanapas Wachiradejkul , Pichayapa Sukmak , Supisara Treveeravoot , Laphatrada Yurasakpong , Nutnicha Rangchaikul , Pimngeon Chatkul , Pitsinee Supapol , Apiwan Arinno , Natnicha Teansuk , Jakkapong Inchai , Sukpapohn Phummisutthigoon , Makha Phongjit , Autsadakorn Loungjan , Nattaphong Akrimajirachoote , Wanangkan Poolsri , Chanat Aonbangkhen , Rungtiwa Khumjiang , Chatchai Muanprasat , Chutima S. Vaddhanaphuti , Pawin Pongkorpsakol","doi":"10.1016/j.jff.2024.106519","DOIUrl":"10.1016/j.jff.2024.106519","url":null,"abstract":"<div><div>Intestinal tight junction disruption initiates pathogenesis of colitis and determines diseases progression. At present, there is no therapeutics that directly corrects intestinal tight junction disassembly. Here, we discovered that <em>Ocimum sanctum L.</em> flower aqueous extract (OSLF) and gallic acid, increased intestinal barrier function by suppressing tight junction-dependent leak pathway permeability after being disrupted by Ca<sup>2+</sup> depletion method. Transepithelial electrical resistance (TER) measurement, western blot analysis, immunofluorescence staining, and molecular docking indicated that OSLF and gallic acid improved intestinal barrier function by inducing tight junction assembly and inhibiting leak pathway permeability in intestinal epithelial cell monolayers via CaMKK-β/AMPK/SIRT-1/ERK-dependent fashion. Therefore, Gallic acid represents a drug candidate for treating diseases associated impaired intestinal barrier function including colitis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106519"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jff.2024.106541
Luyao Liu , Fan Zhao , Dandan Han , Xin Lü , Gang Wu , Yanglei Yi
Inflammatory bowel disease remains a high recurrence rate and broad populations all over the world. Liquiritigenin isolated from licorice possess anti-inflammatory and antioxidative activities, suggesting its potential of treating ulcerative colitis (UC). In this study, we explored the effect of oral liquiritigenin on the DSS-induced mice colitis and underlying mechanisms in the aspect of gut microbiome and intestinal barrier dysfunction. The results showed liquiritigenin had protective effects against DSS-induced mice colitis, including attenuating weight loss, disease activity index score elevation, colon length shortening and histological lesions. In addition, the treatment with liquiritigenin significantly reduced the plasma cytokine levels, TNF-α, IL-1β and IL-6 levels as well as the expression of iNOS and COX-2 compared to control group. Liquiritigenin supplementation also led to a restoration of oxidative homeostasis, as indicated by a decrease of myeloperoxidase (MPO) and malondialdehyde (MDA) levels and an increase in reduced glutathione (GSH) and total Superoxide Dismutase (T-SOD) activities in the colitis mice. In regulation of mice gut microbiota, liquiritigenin augmented probiotics abundance (e.g., Akkermansia), decreased harmful bacteria (e.g., Turicibacter), and restored Firmicutes/Bacteroidetes balance. Furthermore, the mRNA levels of tight junction (TJ), including ZO-1, occludin, and claudin-1 were downregulated in colitis mice, whereas these changes were reversed by liquiritigenin. As indicated by TEM images and Endoplasmic reticulum stress (ERs) marker genes expression like GRP78, IRE1α, ATF6 and PERK that mice with colitis treated by oral liquiritigenin trended to attenuate ER stress. Collectively, the ameliorating role of liquiritigenin in gut inflammation can be attributed to intestinal barrier modulation, gut microbiome regulation, and ER stress alleviation. These findings provide a new perspective for developing liquiritigenin as a promising functional compound of food origin for preventing and mitigating UC.
{"title":"Liquiritigenin ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function, reducing endoplasmic reticulum stress and modulating gut microbiota","authors":"Luyao Liu , Fan Zhao , Dandan Han , Xin Lü , Gang Wu , Yanglei Yi","doi":"10.1016/j.jff.2024.106541","DOIUrl":"10.1016/j.jff.2024.106541","url":null,"abstract":"<div><div>Inflammatory bowel disease remains a high recurrence rate and broad populations all over the world. Liquiritigenin isolated from licorice possess anti-inflammatory and antioxidative activities, suggesting its potential of treating ulcerative colitis (UC). In this study, we explored the effect of oral liquiritigenin on the DSS-induced mice colitis and underlying mechanisms in the aspect of gut microbiome and intestinal barrier dysfunction. The results showed liquiritigenin had protective effects against DSS-induced mice colitis, including attenuating weight loss, disease activity index score elevation, colon length shortening and histological lesions. In addition, the treatment with liquiritigenin significantly reduced the plasma cytokine levels, TNF-α, IL-1β and IL-6 levels as well as the expression of iNOS and COX-2 compared to control group. Liquiritigenin supplementation also led to a restoration of oxidative homeostasis, as indicated by a decrease of myeloperoxidase (MPO) and malondialdehyde (MDA) levels and an increase in reduced glutathione (GSH) and total Superoxide Dismutase (T-SOD) activities in the colitis mice. In regulation of mice gut microbiota, liquiritigenin augmented probiotics abundance (e.g., <em>Akkermansia</em>), decreased harmful bacteria (e.g., <em>Turicibacter</em>), and restored Firmicutes/Bacteroidetes balance. Furthermore, the mRNA levels of tight junction (TJ), including ZO-1, occludin, and claudin-1 were downregulated in colitis mice, whereas these changes were reversed by liquiritigenin. As indicated by TEM images and Endoplasmic reticulum stress (ERs) marker genes expression like GRP78, IRE1α, ATF6 and PERK that mice with colitis treated by oral liquiritigenin trended to attenuate ER stress. Collectively, the ameliorating role of liquiritigenin in gut inflammation can be attributed to intestinal barrier modulation, gut microbiome regulation, and ER stress alleviation. These findings provide a new perspective for developing liquiritigenin as a promising functional compound of food origin for preventing and mitigating UC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106541"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jff.2024.106530
Kai-Wei Chang , Yen-Ying Kung , Shu-Ling Fu , Ju-Fang Liu , Kun-Chang Wu , Tzu-Hau Shi , Yu-Han Luo , Chao-Hsiung Lin , Jih-Jung Chen , Yueh-Hsin Ping , Tung-Hu Tsai , Muh-Hwa Yang
Objective
MicroRNAs (RNA) are crucial in combating SARS-CoV-2; Some traditional Chinese herbal formulas (CHF) have shown potential against the original SARS-CoV-2 strain but no research explores CHF’s role in regulating microRNAs to combat the virus. This study aimed to investigate whether a herbal-based tea bag, Zheng-Yi-Fang (ZYF), from the modified combination of Jie-Geng-Tang (桔梗湯) and Huopu-Xia-Ling-Tang (藿朴夏苓湯) with Houttuynia cordata and Scutellaria baicalensis, can alleviate mild SARS-CoV-2 variant symptoms through microRNA regulation.
Methods
Patients with SARS-CoV-2 were recruited via telemedicine services at Taipei Veterans General Hospital from August to December 2022. Participants were randomly assigned to the ZYF group or a control group receiving standard Western medicines for symptom relief. Efficacy was evaluated by clinical symptom scores and the duration for positive antigen results to turn negative. Additional assays assessed spike protein fusion, viral main protease (Mpro) activity, IL-6/IL-8 secretion, and miRNA induction.
Results
ZYF demonstrated efficacy in alleviating the symptoms of SARS-CoV-2 variants infection in the nasal, throat, upper respiratory areas, and gastrointestinal tract, while reducing the time required for positive antigen results to turn negative. ZYF inhibited spike protein fusion, regulated miRNA-98 to decrease ACE2 and TMPRSS2 expression, and inhibited Mpro activity. ZYF also modulated miRNA-146a expression, reducing IL-6/IL-8 secretion.
Conclusions
Our findings suggest that the herbal-based tea bag offers a novel antiviral approach against SARS-CoV-2 variants by modulating miRNAs, reducing viral entry and IL-6/IL-8 secretion, and inhibiting Mpro activity.
{"title":"Herbal-based tea bag reduces SARS-CoV-2 variant symptoms and infection duration via microRNA regulation: Clinical and mechanistic insights","authors":"Kai-Wei Chang , Yen-Ying Kung , Shu-Ling Fu , Ju-Fang Liu , Kun-Chang Wu , Tzu-Hau Shi , Yu-Han Luo , Chao-Hsiung Lin , Jih-Jung Chen , Yueh-Hsin Ping , Tung-Hu Tsai , Muh-Hwa Yang","doi":"10.1016/j.jff.2024.106530","DOIUrl":"10.1016/j.jff.2024.106530","url":null,"abstract":"<div><h3>Objective</h3><div>MicroRNAs (RNA) are crucial in combating SARS-CoV-2; Some traditional Chinese herbal formulas (CHF) have shown potential against the original SARS-CoV-2 strain but no research explores CHF’s role in regulating microRNAs to combat the virus. This study aimed to investigate whether a herbal-based tea bag, Zheng-Yi-Fang (ZYF), from the modified combination of Jie-Geng-Tang (桔梗湯) and Huopu-Xia-Ling-Tang (藿朴夏苓湯) with <em>Houttuynia cordata</em> and <em>Scutellaria baicalensis</em>, can alleviate mild SARS-CoV-2 variant symptoms through microRNA regulation.</div></div><div><h3>Methods</h3><div>Patients with SARS-CoV-2 were recruited via telemedicine services at Taipei Veterans General Hospital from August to December 2022. Participants were randomly assigned to the ZYF group or a control group receiving standard Western medicines for symptom relief. Efficacy was evaluated by clinical symptom scores and the duration for positive antigen results to turn negative. Additional assays assessed spike protein fusion, viral main protease (M<sup>pro</sup>) activity, IL-6/IL-8 secretion, and miRNA induction.</div></div><div><h3>Results</h3><div>ZYF demonstrated efficacy in alleviating the symptoms of SARS-CoV-2 variants infection in the nasal, throat, upper respiratory areas, and gastrointestinal tract, while reducing the time required for positive antigen results to turn negative. ZYF inhibited spike protein fusion, regulated miRNA-98 to decrease ACE2 and TMPRSS2 expression, and inhibited M<sup>pro</sup> activity. ZYF also modulated miRNA-146a expression, reducing IL-6/IL-8 secretion.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that the herbal-based tea bag offers a novel antiviral approach against SARS-CoV-2 variants by modulating miRNAs, reducing viral entry and IL-6/IL-8 secretion, and inhibiting M<sup>pro</sup> activity.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106530"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jff.2024.106548
Seung Tae Im , Wook Chul Kim , Yun-Su Lee , Ji-Yul Kim , Kyung Lee , Gun-Woo Oh , Jeong Min Lee , Mi-Jin Yim , Dae-Sung Lee , Seok-Chun Ko , Seung-Hong Lee
Obesity is a deleterious medical condition that can lead to lipid metabolism dysregulation and various metabolic disorders. The lipid-reducing and hypoglycemic effects of Rosa rugosa have been demonstrated both in vitro and in vivo. However, the mechanisms of the anti-obesity components and gut microbiota regulating potential of R. rugosa are not fully understood. Therefore, our study investigated the role of R. rugosa phenolic-enriched extract (RREE) in high-fat diet (HFD)-induced obesity and microbiome alterations. The results showed that RREE administration (300 mg/kg/day for 7 weeks) decreased body and organ weight by improving glucolipid metabolism and inhibiting lipid accumulation. Moreover, RREE restored gut permeability by regulating the expression levels of tight junction proteins and improving microbial composition and diversity. Taken together, the findings suggested the potential of RREE as a potent prebiotic agent that can ameliorate HFD-induced obesity and its associated metabolic disorders by regulating glucolipid metabolism and restoring the gut microbiota.
{"title":"Phenolic-enriched Rosa rugosa extract ameliorates obesity-associated metabolic disorders and regulates gut microbiota in high-fat diet-fed mice","authors":"Seung Tae Im , Wook Chul Kim , Yun-Su Lee , Ji-Yul Kim , Kyung Lee , Gun-Woo Oh , Jeong Min Lee , Mi-Jin Yim , Dae-Sung Lee , Seok-Chun Ko , Seung-Hong Lee","doi":"10.1016/j.jff.2024.106548","DOIUrl":"10.1016/j.jff.2024.106548","url":null,"abstract":"<div><div>Obesity is a deleterious medical condition that can lead to lipid metabolism dysregulation and various metabolic disorders. The lipid-reducing and hypoglycemic effects of <em>Rosa rugosa</em> have been demonstrated both <em>in vitro</em> and <em>in vivo</em>. However, the mechanisms of the anti-obesity components and gut microbiota regulating potential of <em>R. rugosa</em> are not fully understood. Therefore, our study investigated the role of <em>R. rugosa</em> phenolic-enriched extract (RREE) in high-fat diet (HFD)-induced obesity and microbiome alterations. The results showed that RREE administration (300 mg/kg/day for 7 weeks) decreased body and organ weight by improving glucolipid metabolism and inhibiting lipid accumulation. Moreover, RREE restored gut permeability by regulating the expression levels of tight junction proteins and improving microbial composition and diversity. Taken together, the findings suggested the potential of RREE as a potent prebiotic agent that can ameliorate HFD-induced obesity and its associated metabolic disorders by regulating glucolipid metabolism and restoring the gut microbiota.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106548"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.jff.2024.106513
Jannat Bibi , Yao Lei , Katarzyna Kotwica-Mojzych , Mariola Głowacka , Mariusz Mojzych
{"title":"Corrigendum to “The power of pomegranate as natural supplement remedy for sportsmen and athletes: A systematic review and meta-analysis” [J. Funct. Foods 121 (2024) 106453]","authors":"Jannat Bibi , Yao Lei , Katarzyna Kotwica-Mojzych , Mariola Głowacka , Mariusz Mojzych","doi":"10.1016/j.jff.2024.106513","DOIUrl":"10.1016/j.jff.2024.106513","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106513"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-28DOI: 10.1016/j.jff.2024.106542
Hao Duan , Wei Wang , Ruiling Li , Siqi Sun , Yuqi Feng , Honghan Zhang , Xinhua Song , Yuhui Zhang , Ningyuan Li , Guopeng Chen , Lihua Yao , Chao Wang , Huiling Wang , Zhongchun Liu
The global burden of major depressive disorder (MDD) is increasing. Preclinical and clinical studies have indicated a close association between levels of trace elements and the incidence of MDD. However, little is known about the association between selenium levels and MDD. Methionine sulfoxide reductase B1 (MSRB1) is a selenoprotein regulated by dietary selenium levels that can indirectly clear reactive oxygen species (ROS). Here we show that supplementing the diet with L-selenomethionine, the most common organic selenium compound in organisms, effectively reduces the susceptibility of mice to depressive-like behavior induced by unpredictable chronic mild stress (CUMS). Furthermore, by knocking down MSRB1 in primary astrocytes and mouse hippocampi, we demonstrate that L-selenomethionine exerts its protective effect by increasing MSRB1 levels in hippocampal astrocytes. MSRB1 reduces ROS-induced neuroinflammation in astrocytes by indirectly clearing ROS. Our findings not only reveal a role for dietary selenium in regulating the susceptibility of mice to CUMS-induced depressive-like behaviors but also further identify the specific selenoprotein mediating this effect. These findings provide a potential dietary approach for preventing MDD in clinical practice and the motivation for further preclinical studies.
{"title":"Dietary selenium supplementation reduces susceptibility to depression-like behaviors in mice by increasing MSRB1 expression in hippocampal astrocytes","authors":"Hao Duan , Wei Wang , Ruiling Li , Siqi Sun , Yuqi Feng , Honghan Zhang , Xinhua Song , Yuhui Zhang , Ningyuan Li , Guopeng Chen , Lihua Yao , Chao Wang , Huiling Wang , Zhongchun Liu","doi":"10.1016/j.jff.2024.106542","DOIUrl":"10.1016/j.jff.2024.106542","url":null,"abstract":"<div><div>The global burden of major depressive disorder (MDD) is increasing. Preclinical and clinical studies have indicated a close association between levels of trace elements and the incidence of MDD. However, little is known about the association between selenium levels and MDD. Methionine sulfoxide reductase B1 (MSRB1) is a selenoprotein regulated by dietary selenium levels that can indirectly clear reactive oxygen species (ROS). Here we show that supplementing the diet with L-selenomethionine, the most common organic selenium compound in organisms, effectively reduces the susceptibility of mice to depressive-like behavior induced by unpredictable chronic mild stress (CUMS). Furthermore, by knocking down MSRB1 in primary astrocytes and mouse hippocampi, we demonstrate that L-selenomethionine exerts its protective effect by increasing MSRB1 levels in hippocampal astrocytes. MSRB1 reduces ROS-induced neuroinflammation in astrocytes by indirectly clearing ROS. Our findings not only reveal a role for dietary selenium in regulating the susceptibility of mice to CUMS-induced depressive-like behaviors but also further identify the specific selenoprotein mediating this effect. These findings provide a potential dietary approach for preventing MDD in clinical practice and the motivation for further preclinical studies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106542"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-26DOI: 10.1016/j.jff.2024.106529
Lin Wang , Hongyan Zhao , Xianchen Du , Yan Cao , Jingyu Wu , Pan Guo , Qitao Zhao , Qingmei Guo
The objective of this study was to examine the effect of rosehip (Rosa rugosa Thunb.) ethanol extract (RRE) on liver fibrosis in mice and the underlying molecular mechanisms. RRE has no acute oral toxicity, and the MTD in mice is 46.14 g/kg. Histopathological analysis showed that RRE significantly ameliorated inflammation, necrosis, and apoptosis of hepatocytes and collagen deposition caused by CCl4. Further assays indicated that RRE significantly suppressed the production of MDA while markedly increasing the levels of SOD and GSH in the liver. The AST, ALT, IL-6, IL-1β, TNF-α, HA, LN, PCIII, and IVC levels in serum were decreased by RRE. Transcriptome analysis shows that RRE significantly upregulates the PPAR signaling pathway. The RT-q PCR results further confirmed the RRE up-regulating Pparγ, Rxrα, and Plin5 in the PPAR signaling pathway. The Western blot and immunohistochemical results indicate that RRE upregulated PPARγ, RXRα, and Perilipin 5 while downregulating α-SMA and COL1A1 expression. The results indicate that RRE can ameliorate liver fibrosis in mice by upregulating the PPAR signaling pathway.
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