Journal of Functional Foods最新文献_第7页

Fucoxanthin mitigates lipopolysaccharide-induced acute liver injury by inhibiting hepatocyte apoptosis and pyroptosis 岩藻黄素通过抑制肝细胞凋亡和焦亡来减轻脂多糖诱导的急性肝损伤

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.jff.2026.107180

Yu-Hong Yang , Qing-Yan Zou , Cheng-Yu Yang , Hui Li , Zi-Jian Wu , Shi-Xiang Wu , Yan Guan , Ya-Ru Li , Kazuo Miyashita , Chang-Sheng Zhao , Lei Du

Acute liver injury (ALI) induced by lipopolysaccharide (LPS) represents a critical clinical challenge due to its high mortality and limited therapeutic options. Fucoxanthin (Fx), a marine-derived xanthophyll carotenoid, exerts hepatoprotective potential owing to its strong anti-inflammatory and antioxidant properties. However, its protective role against LPS-induced ALI remains poorly understood. This study elucidated the protective effect and underlying mechanism of Fx against LPS-induced ALI in both a mouse model and a hepatocyte-macrophage co-culture system. Oral administration of 50 or 200 mg/kg body weight Fx once daily for 7 consecutive days notably attenuated LPS-induced increase in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and improved pathological changes in mouse livers. In the co-culture system of AML12 hepatocytes and RAW264.7 macrophages, Fx treatment dose-dependently alleviated LPS-induced damage to AML12 cells, as evidenced by reduced lactate dehydrogenase (LDH) release and maintained cell viability. Mechanistically, Fx significantly suppressed macrophage overactivation-mediated hepatic inflammatory responses and oxidative stress induced by LPS. Specifically, Fx downregulated pro-inflammatory molecules, such as tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), IL-6, IL-18, and inducible nitric oxide synthase (iNOS), as well as inhibited intracellular reactive oxygen species (ROS) generation. These effects collectively suppressed excessive hepatocyte apoptosis via blocking the intrinsic apoptotic signaling pathway and inhibited massive hepatocyte pyroptosis through inactivating the NOD-like receptor family pyrin domain containing 3 (NLRP3)/caspase-1/ gasdermin D (GSDMD)-mediated pyroptosis pathway. Collectively, these findings suggest that Fx may serve as a promising functional ingredient for preventing ALI.

脂多糖（LPS）引起的急性肝损伤（ALI）由于其高死亡率和有限的治疗选择而成为一个关键的临床挑战。岩藻黄素（Fx）是一种源自海洋的类黄素类胡萝卜素，由于其强大的抗炎和抗氧化特性，具有保护肝脏的潜力。然而，其对lps诱导的ALI的保护作用仍然知之甚少。本研究在小鼠模型和肝细胞-巨噬细胞共培养系统中阐明了Fx对lps诱导的ALI的保护作用及其机制。口服Fx 50或200 mg/kg体重，每天1次，连续7天，可显著降低lps诱导的血清谷丙转氨酶（ALT）和天冬氨酸转氨酶（AST）水平升高，改善小鼠肝脏病理变化。在AML12肝细胞和RAW264.7巨噬细胞共培养系统中，Fx剂量依赖性地减轻了lps诱导的AML12细胞损伤，表现为乳酸脱氢酶（LDH）释放减少，维持了细胞活力。机制上，Fx显著抑制巨噬细胞过度激活介导的肝脏炎症反应和LPS诱导的氧化应激。具体而言，Fx下调促炎分子，如肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β)、IL-6、IL-18和诱导型一氧化氮合酶（iNOS），并抑制细胞内活性氧（ROS）的产生。这些作用通过阻断固有的凋亡信号通路共同抑制过量的肝细胞凋亡，并通过失活nod样受体家族pyrin结构域3 (NLRP3)/caspase-1/ gasdermin D （GSDMD）介导的焦亡途径抑制大量肝细胞焦亡。总的来说，这些发现表明Fx可能是预防ALI的有希望的功能成分。

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引用次数: 0

Anticancer effects of Chlorella sorokiniana Shihira and R. W. Krauss extract via Bcl-2/Bax modulation and AMPK-α activation in hepatoma cells 小球藻Shihira和R. W. Krauss提取物通过Bcl-2/Bax调节和AMPK-α活化对肝癌细胞的抗癌作用

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.jff.2026.107172

Min Ho Han , Min Ho Kang , Youn Seon Hwang , Seung Won Nam , Chang Soo Lee , Jin Woo Kim

Research on selectively inducing apoptosis in cancer cells is ongoing, yet effective natural compounds with fewer side effects are still needed. This study investigated the anticancer potential of Chlorella sorokiniana extract (CSE) in hepatoma cells. CSE showed high TPC (4.49 mg GAE/g DM) and TFC (0.86 mg QE/g DM) with strong ROS scavenging activity (9.0–45.0%). LC–MS/MS analysis suggested lutein, liquiritigenin, isorhamnetin, kaempferol as key metabolites responsible for apoptotic effects. CSE suppressed Hep3B cell viability by 22.1% without cytotoxicity in HepG2 cells and induced apoptosis via upregulation of Bax, AMPK-α, and caspase-3 (28.9–83.5%) and downregulation of Bcl-2 and VEGF (33.0–43.9%). Notably, apoptosis was enhanced (25.7%) in p53-deficient Hep3B cells, implying heightened susceptibility to CSE. These findings suggest C. sorokiniana has the potential to serve as a natural compound capable of selectively inducing apoptosis in liver cancer cells, indicating its potential as a foundational material for drug development.

选择性诱导癌细胞凋亡的研究正在进行中，但仍然需要副作用小的有效天然化合物。研究了小球藻提取物（Chlorella sorokiniana extract， CSE）对肝癌细胞的抗癌作用。CSE具有较高的TPC （4.49 mg GAE/g DM）和TFC (0.86 mg QE/g DM)，具有较强的ROS清除活性（9.0% ~ 45.0%）。LC-MS /MS分析提示叶黄素、利尿素、异鼠李素、山奈酚是参与细胞凋亡的主要代谢物。CSE通过上调Bax、AMPK-α和caspase-3(28.9-83.5%)，下调Bcl-2和VEGF（33.0-43.9%）诱导HepG2细胞凋亡，对Hep3B细胞的活性有22.1%的抑制作用。值得注意的是，p53缺失的Hep3B细胞凋亡增加（25.7%），表明对CSE的易感性增加。这些发现表明sorokiniana具有作为一种能够选择性诱导肝癌细胞凋亡的天然化合物的潜力，表明其作为药物开发的基础材料的潜力。

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引用次数: 0

A synbiotic supplement reduces body fat and increases GLP-1 secretion in a pilot clinical study 合成补充剂减少体脂和增加GLP-1分泌在试点临床研究

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-20 DOI: 10.1016/j.jff.2026.107171

Chiao-Wei Lin , Hsin-Bai Zou , Rou-An Chen , Chi-Shan Li , Chia-Ying Lin , Cheng-Chih Hsu

Obesity is closely associated with gut microbiota and their metabolites. We developed a multi-component synbiotic supplement that includes lychee polyphenols, Bifidobacterium longum, Bifidobacterium animalis, methionine, and other supportive ingredients such as prebiotics and postbiotics. A 5-week pilot clinical trial was conducted to evaluate its effects on body composition, metabolic markers, gut microbiota-derived metabolites, and GLP-1 secretion. The results showed significant reductions in body weight, fat mass, visceral fat, HbA1c, insulin resistance, and blood lipids. Metabolite analysis revealed increases in short-chain fatty acids and tryptophan metabolites, including acetic acid, isobutyric acid, isovaleric acid, serotonin, and indolelactic acid. GLP-1 secretion increased in both humans and mice, with a notable rise in Akkermansia muciniphila observed in mice given the synbiotic. These findings suggest that this synbiotic supplementation could serve as a potential approach for improving metabolic health and reducing obesity.

肥胖与肠道菌群及其代谢产物密切相关。我们开发了一种多组分合成补充剂，包括荔枝多酚、长双歧杆菌、动物双歧杆菌、蛋氨酸和其他支持性成分，如益生元和益生后。一项为期5周的先导临床试验评估了其对身体成分、代谢标志物、肠道微生物衍生代谢物和GLP-1分泌的影响。结果显示体重、脂肪量、内脏脂肪、糖化血红蛋白、胰岛素抵抗和血脂显著降低。代谢物分析显示短链脂肪酸和色氨酸代谢物增加，包括乙酸、异丁酸、异戊酸、血清素和吲哚乳酸。人和小鼠的GLP-1分泌均增加，在给予合成物的小鼠中观察到嗜粘液阿克曼氏菌的显著增加。这些发现表明，这种合成补充剂可以作为一种改善代谢健康和减少肥胖的潜在方法。

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引用次数: 0

Heat-killed Bifidobacterium longum LB-P23 ameliorates metabolic dysfunction in high-fat and high-sucrose diet-fed mice through gut microbiota modulation 热灭活长双歧杆菌LB-P23通过调节肠道菌群改善高脂高糖饮食小鼠的代谢功能障碍

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-20 DOI: 10.1016/j.jff.2026.107160

Won Jun Kim , Mikyung Song , Hangsu Cho , Ahjin Kim , Jaeseok Shim , Kyoungsub Song

The gut microbiota plays a pivotal role in obesity and metabolic disorders. This study evaluated the anti-obesity effects of heat-killed Bifidobacterium longum LB-P23 in a high-fat, high-sucrose diet-induced obese mouse model. Mice received low (1 × 10⁸ TCC) or high (1 × 10⁹ TCC) doses of B. longum LB-P23 for 8 weeks. High-dose B. longum LB-P23 significantly reduced body weight gain, insulin resistance and hepatic steatosis, while enhancing thermogenesis, and gut barrier integrity by regulating genes related to insulin signaling, β-oxidation, thermogenesis, and tight junctions. It also alleviated diet-induced dysbiosis, reducing Parabacteroides, and Colidextribacter, while enriching Romboustia, whose abundance positively correlated with plasma IL-22, indicating activation of IL-22 signaling. In vitro, B. longum LB-P23 suppressed lipid accumulation in 3T3-L1 adipocytes. Collectively, heat-killed B. longum LB-P23 exerts multi-organ metabolic benefits through modulation of insulin signaling, thermogenesis, and gut–immune interactions, supporting its potential as a safe anti-obesity intervention.

肠道菌群在肥胖和代谢紊乱中起着关键作用。本研究在高脂肪、高糖饮食诱导的肥胖小鼠模型中评估了热灭活长双歧杆菌LB-P23的抗肥胖作用。小鼠接受低剂量（1 × 108 TCC）或高剂量（1 × 109 TCC）长梭菌LB-P23治疗8周。高剂量B. longum LB-P23可显著降低体重增加、胰岛素抵抗和肝脏脂肪变性，同时通过调节胰岛素信号、β-氧化、产热和紧密连接相关基因，增强产热和肠道屏障完整性。它还减轻了饮食引起的生态失调，减少了拟副杆菌和Colidextribacter，同时丰富了Romboustia，其丰度与血浆IL-22正相关，表明IL-22信号通路被激活。在体外实验中，长刺草LB-P23抑制3T3-L1脂肪细胞的脂质积累。综上所述，热杀伤长芽胞杆菌LB-P23通过调节胰岛素信号、产热和肠道免疫相互作用发挥多器官代谢益处，支持其作为安全抗肥胖干预的潜力。

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引用次数: 0

Dietary polyphenols as functional food bioactives: Nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant and immunomodulatory mechanisms in combating bacterial infections 膳食多酚作为功能性食品生物活性物质：核因子-红细胞2相关因子2 （Nrf2）介导的抗氧化和免疫调节机制在对抗细菌感染中的作用

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-18 DOI: 10.1016/j.jff.2026.107165

Nada Ahmed , Mohamed El-Fateh , Moussa S. Diarra , Xin Zhao

The rising threat of antimicrobial resistance (AMR) highlights the need for novel strategies to fight against microbial pathogens while strengthening host defenses. Dietary polyphenols abundant in fruits, vegetables, and food byproducts, could offer dual antimicrobial and host-protective effects. At the same time, nuclear factor erythroid 2-related factor 2 (Nrf2) activation emerges as one of key mechanisms that extend beyond antioxidant control to regulate cytokine production and innate immune signaling. This review discusses the underexplored role of polyphenol in activating Nrf2 as a signaling hub that coordinates host immune responses against bacterial infection. Despite bioavailability hurdles, polyphenols could offer a promise direction for functional foods-based strategies in infection control.

抗菌素耐药性（AMR）的威胁日益严重，这表明需要新的策略来对抗微生物病原体，同时加强宿主的防御。富含水果、蔬菜和食品副产品的膳食多酚具有抗菌和保护宿主的双重作用。与此同时，核因子红细胞2相关因子2 （Nrf2）的激活成为超越抗氧化控制，调节细胞因子产生和先天免疫信号传导的关键机制之一。这篇综述讨论了多酚在激活Nrf2作为协调宿主免疫反应对抗细菌感染的信号中枢中的作用。尽管存在生物利用度障碍，但多酚可以为基于功能食品的感染控制策略提供一个有希望的方向。

引用次数: 0

A natural sulfated polysaccharide of high molecular weight, a fucoidan isolated from Undaria pinnatifida, is incorporated into Peyer's patches of mice via M cells and induces innate immune responses 从裙带菜中分离出一种高分子量的天然硫酸酸化多糖岩藻聚糖，通过M细胞进入小鼠的Peyer's斑块，诱导先天免疫反应

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.1016/j.jff.2025.107147

Kyoko Hayashi , Jung-Bum Lee , Kohei Sasaki , Satomi Asai

Fucoidans (FUs) are sulfated glycans primarily found in marine algae and exhibit various bioactivities. Mekabu FU, from the edible brown alga Undaria pinnatifida, enhances innate and adaptive immunity and exerts protective effects in virus-infected mice, although its mechanisms remain unclear. We aimed to investigate the fate of mekabu FU after oral administration in mice by monitoring the uptake of fluorescence-labeled FU (FL-FU) into Peyer's patches (PPs) through M cells in the intestine and conducting DNA microarray analysis of PPs. FL-FU was observed in M cells 30 min after oral administration in mice. DNA microarray analysis of gene expression in PPs revealed that FU administration altered the expression of genes involved in immune regulation. Orally administered FL-FU was not metabolized into small fragments upon excretion from the mouse intestine, suggesting that mekabu FU suppresses viral infections by modulating intestinal immunity after incorporation into PPs through M cells.

岩藻聚糖（FUs）是一种主要存在于海洋藻类中的磺化聚糖，具有多种生物活性。Mekabu FU来自可食用褐藻裙带藻，可增强病毒感染小鼠的先天和适应性免疫，并发挥保护作用，尽管其机制尚不清楚。我们的目的是通过监测荧光标记FU （FL-FU）通过肠道M细胞进入Peyer's patches (PPs)，并对PPs进行DNA芯片分析，研究口服给药后小鼠mekabu FU的命运。口服给药30 min后，小鼠M细胞中观察到FL-FU的变化。基因表达的DNA芯片分析显示，FU给药改变了参与免疫调节的基因的表达。口服给药的FL-FU在从小鼠肠道排出后不会代谢成小片段，这表明mekabu FU通过M细胞掺入PPs后通过调节肠道免疫来抑制病毒感染。

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引用次数: 0

Fractionation, characterization, and gastrointestinal stability of anticancer and antioxidant peptides from sea cucumber (Holothuria scabra) hydrolysates 海参（Holothuria scabra）水解物中抗癌和抗氧化肽的分离、表征和胃肠道稳定性

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1016/j.jff.2026.107173

Supansa Saiwong , Utoomporn Surayot , Narongchai Autsavapromporn , Charin Tachapan , Yuthana Phimolsiripol , Sang Guan You , Hui Hong , Sun Young Lim , Sutee Wangtueai

Sea cucumber hydrolysates with antioxidant and anticancer properties were prepared using papain hydrolysis. The protein hydrolysates were fractionated into peptide groups of >10 kDa (SCPH-I), 3–10 kDa (SCPH-II), 1–3 kDa (SCPH-III), and < 1 kDa (SCPH-IV) using ultrafiltration membranes. The antioxidant and anticancer properties of both crude and fractionated hydrolysates were evaluated. The SCPH-III fraction exhibited the most potent antioxidant properties, with scavenging activities against the 2,2-diphenyl-1-picryl hydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), hydrogen peroxide (H₂O₂), and hydroxyl (OH) radicals of 87.96%, 78.48%, 39.39%, and 80.29%, respectively. The antiproliferative effect of the four fractions in the HepG2 cell model showed no significant difference (p > 0.05). The SCPH-III fraction was selected for peptide characterization using LC-MS/MS with de novo sequencing. Eighteen peptides were identified, among which two peptides demonstrated potent antioxidant and anticancer potential: Thr-Ser-Asp-Gly-Gln-Asn-Tyr-Leu-Leu-Leu-Lys and Phe-His-Val-Asp-Glu-Leu-Lys. The SCPH-III fraction induced significant morphological changes and apoptosis in HepG2 cells, with 87.30% of cells undergoing apoptosis at a 5 mg/mL concentration. Furthermore, the SCPH-III fraction was relatively stable under in vitro gastrointestinal digestion, showing a slight decrease in DPPH and OH radical scavenging activities, whereas the ABTS radical scavenging activity and anticancer activity increased significantly (p < 0.05).

采用木瓜蛋白酶水解法制备了具有抗氧化和抗癌特性的海参水解物。用超滤膜将蛋白水解产物分离成10 kDa （SCPH-I）、3-10 kDa （SCPH-II）、1 - 3 kDa （SCPH-III）和1 kDa （SCPH-IV）的肽组。对粗水解产物和分馏水解产物的抗氧化和抗癌性能进行了评价。SCPH-III部位对2,2-二苯基-1-吡啶酰肼（DPPH）、2,2 ' -氮基-双（3-乙基苯并噻唑-6-磺酸）、过氧化氢（H2O2）和羟基（OH）自由基的清除率分别为87.96%、78.48%、39.39%和80.29%，具有较强的抗氧化活性。四组分在HepG2细胞模型中的抗增殖作用差异无统计学意义（p > 0.05）。选择SCPH-III部分，采用LC-MS/MS与从头测序进行肽段表征。共鉴定出18条多肽，其中2条多肽具有较强的抗氧化和抗癌作用：thr - ser - asp - gly - gln - asn - tyrl - leu - leu - lys和pheh - his - val - asp - glu - leu - lys。SCPH-III组分在HepG2细胞中引起了明显的形态学改变和凋亡，在5 mg/mL浓度下，87.30%的细胞发生凋亡。体外胃肠消化作用下，SCPH-III组分相对稳定，对DPPH和OH自由基的清除能力略有下降，而对ABTS自由基的清除能力和抗癌能力显著提高（p < 0.05）。

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引用次数: 0

Sparalide B from Sparassis latifolia inhibits early adipogenesis in 3T3-L1 adipocytes via β-catenin-dependent downregulation of PPARγ and C/EBPα 疏树苷B通过β-catenin依赖性下调PPARγ和C/EBPα抑制3T3-L1脂肪细胞的早期脂肪形成

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-17 DOI: 10.1016/j.jff.2026.107167

Hyeok Jin Choi , Jeong Won Choi , So Jung Park , Gyeong Eun Im , Youngki Park , Kyoung Tae Lee , Jin Boo Jeong

Sparalide B, a phthalide isolated from Sparassis latifolia (S. latifolia), was structurally assigned as 4,5,7-trihydroxy-6-ethoxyphthalide by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) (¹H, ¹³C, heteronuclear multiple bond correlation (HMBC)) analyses. In 3T3-L1 adipocytes, sparalide B (2.5–20 μg/mL) significantly reduced lipid droplet accumulation in a dose-dependent manner, as quantified by Oil Red O staining at concentrations that did not affect cell viability. Western blotting showed decreased expression of adipogenic transcription factors (PPARγ, C/EBPα) and lipid droplet-associated/lipolytic proteins (perilipin-1, ATGL, HSL), alongside increased levels of thermogenesis/energy-metabolism markers (UCP2, PGC-1α, p-AMPK, AMPK). Stage-restricted treatments revealed that efficacy was confined to the early differentiation window (D0-D2), with little effect during D2-D4 or D4-D8. Mechanistically, sparalide B elevated β-catenin during D0-D2; β-catenin knockdown abrogated the compound's suppression of PPARγ/C/EBPα and its inhibition of lipid accumulation. These findings indicate that sparalide B targets early adipogenesis through β-catenin-dependent signaling to suppress lipid formation, highlighting this natural phthalide as a promising anti-obesity lead.

通过高分辨率电喷雾质谱（HR-ESI-MS）和核磁共振（NMR）（1H, 13C，异核多键相关（HMBC））分析，从菝葜（S. latifolia）中分离得到邻苯酞类化合物Sparalide B，结构为4,5,7-三羟基-6-乙氧基邻苯酞。在3T3-L1脂肪细胞中，经油红O染色，在不影响细胞活力的浓度下，稀疏胺B （2.5-20 μg/mL）以剂量依赖性方式显著降低脂滴积累。Western blotting显示，脂肪生成转录因子（PPARγ、C/EBPα）和脂滴相关/脂解蛋白（perilipin-1、ATGL、HSL）的表达下降，产热/能量代谢标志物（UCP2、PGC-1α、p-AMPK、AMPK）水平升高。限期治疗显示，疗效仅限于早期分化窗口（D0-D2），在D2-D4或D4-D8期间效果不大。在机制上，疏肽B在D0-D2期间升高β-catenin；β-catenin的敲除消除了该化合物对PPARγ/C/EBPα的抑制作用及其对脂质积累的抑制作用。这些发现表明，sparalide B通过β-连环蛋白依赖的信号传导抑制脂质形成，靶向早期脂肪形成，突出了这种天然邻苯酞作为一种有希望的抗肥胖先导物。

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引用次数: 0

Effects of consumption of selenium biofortified milk on antioxidant and inflammatory biomarkers in children with autism spectrum disorder: A controlled, single-blind intervention study 食用硒生物强化牛奶对自闭症谱系障碍儿童抗氧化和炎症生物标志物的影响：一项对照单盲干预研究

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-02-01 Epub Date: 2026-01-16 DOI: 10.1016/j.jff.2026.107161

Marta Liliane de Vasconcelos , Fábio da Veiga Ued , Marcia Delgado da Cruz Gomes , Luiz Fernando Costa e Silva , Giovana Fumes Ghantous , Arlindo Saran Netto , João Alberto Negrão , Jeremy Paul Hill , Ana Maria Centola Vidal

Children with Autism Spectrum Disorder (ASD) often exhibit food selectivity, which may be associated with inadequate Selenium (Se) intake and imbalances in serum levels of enzymatic and non-enzymatic antioxidants as well as inflammatory cytokines. Several studies suggest an association between autism and increased oxidative stress. However, clinical studies in this population remain scarce due to methodological challenges, as do studies assessing Se status and the effects of Se biofortified foods. In this context, the present study aimed to quantify serum levels of Se, zinc (Zn), vitamin E (VitE), antioxidant enzymes, and pro-inflammatory cytokines in children with ASD before and after dietary intervention with Se biofortified cow's milk. Seventeen children with ASD aged between 3 and 10 years were selected and allocated into a conventional milk (n = 8), and the Se biofortification group (n = 9), which received cow's milk containing 190 μg/L of Se for 12 weeks (84 days). Serum levels of enzymatic and non-enzymatic antioxidants and gene expression of pro-inflammatory cytokines were measured at baseline and the end of the study. Following the intervention, serum Se levels were significantly higher in the biofortified group (62.97 vs 102.82 μg/dL, p < 0.05). No significant differences were observed in antioxidant enzyme expression; although not statistically significant, greater glutathione peroxidase 1 (GPx1) and catalase (CAT) levels were observed post-intervention, as well as a tendency toward lower VitE and Zn levels. Among the measured pro-inflammatory cytokines, only interleukin 8 (IL-8) significantly increased. Tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) showed a positive correlation with antioxidant enzymes (p < 0.05). These findings suggest that Se biofortification of milk may serve as a potential nutritional strategy for children with ASD.

患有自闭症谱系障碍（ASD）的儿童通常表现出食物选择性，这可能与硒（Se）摄入不足、血清酶促和非酶促抗氧化剂以及炎症细胞因子水平失衡有关。几项研究表明，自闭症与氧化应激增加有关。然而，由于方法学上的挑战，对这一人群的临床研究仍然很少，评估硒状况和硒生物强化食品效果的研究也是如此。在此背景下，本研究旨在量化ASD儿童在硒生物强化牛奶饮食干预前后的血清硒、锌（Zn）、维生素E （VitE）、抗氧化酶和促炎细胞因子水平。选取17名年龄在3 ~ 10岁之间的ASD儿童，将其分为常规牛奶组（n = 8）和硒生物强化组（n = 9），他们连续12周（84天）饮用含硒190 μg/L的牛奶。在基线和研究结束时测量血清酶促和非酶促抗氧化剂水平以及促炎细胞因子的基因表达。干预后，生物强化组血清硒水平显著高于对照组（62.97 vs 102.82 μg/dL, p < 0.05）。抗氧化酶表达差异无统计学意义；虽然没有统计学意义，但干预后观察到谷胱甘肽过氧化物酶1 （GPx1）和过氧化氢酶（CAT）水平升高，以及VitE和Zn水平降低的趋势。在检测的促炎细胞因子中，只有白细胞介素8 （IL-8）显著升高。肿瘤坏死因子-α (TNF-α)和干扰素-γ (IFN-γ)与抗氧化酶呈正相关（p < 0.05）。这些发现表明，牛奶中的硒生物强化可能是自闭症儿童的一种潜在营养策略。

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引用次数: 0

UTMD technology mediates the application of resveratrol nanocarriers in the diagnosis and treatment of gastric cancer UTMD技术介导白藜芦醇纳米载体在胃癌诊断和治疗中的应用

IF 4 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods

Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jff.2025.107143

Xiao Gan , Qiqing Zheng , Pengfei Wang , Zhewei Zhang , Bohan Zhang , Jingyue Li , Liang Wang , Zhilin Zhao

Gastric cancer remains one of the most prevalent and lethal malignancies worldwide. Resveratrol has demonstrated significant anticancer properties across multiple cancer types, including gastric cancer. However, its therapeutic efficacy is limited by poor bioavailability and rapid metabolic clearance. Recent advances in nanotechnology have enabled the development of innovative drug delivery systems combining ultrasound-targeted microbubble destruction (UTMD) technology with nanocarriers, Exploiting the enhanced permeability and retention (EPR) effect, nanotech-based drug delivery system facilitate enhanced vascular penetration and tumor tissue accumulation, resulting in prolonged systemic circulation, improved therapeutic efficiency, and reduced systemic toxicity. The integration of nanotechnology-based delivery systems with UTMD technology enhances the bioavailability of poorly soluble drugs while providing a safe and targeted approach for resveratrol delivery, thereby optimizing its therapeutic and diagnostic potential in gastric cancer treatment. This review explores the applications of UTMD-mediated resveratrol nanocarriers in the diagnosis and treatment of gastric cancer.

胃癌仍然是世界上最常见和最致命的恶性肿瘤之一。白藜芦醇已被证明对多种癌症有显著的抗癌作用，包括胃癌。然而，其生物利用度差，代谢清除快，限制了其治疗效果。纳米技术的最新进展使创新的药物传递系统得以发展，将超声靶向微泡破坏（UTMD）技术与纳米载体相结合，利用增强的渗透性和滞留性（EPR）效应，纳米技术为基础的药物传递系统促进了血管渗透和肿瘤组织的积累，从而延长了体循环，提高了治疗效率，降低了全身毒性。基于纳米技术的给药系统与UTMD技术的整合提高了难溶性药物的生物利用度，同时为白藜芦醇的给药提供了一种安全且有针对性的方法，从而优化了其在胃癌治疗中的治疗和诊断潜力。本文综述了utmd介导的白藜芦醇纳米载体在胃癌诊断和治疗中的应用。

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