Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107111
Mingming Bao , Dezhi Yang , Qiburi Qiburi , Meng He , Temuqile Temuqile , Huricha Baigude
Nigella sativa, Origanum vulgare, and Malus asiatica are traditionally used for gastrointestinal and metabolic health. A polyherbal formulation combining these herbs (NOM) has been employed as a folk remedy for diabetes, yet its efficacy and toxicity remain underexplored. This study identified bioactive compounds in NOM via UPLC-qTOF MS and assessed antidiabetic effects and cytotoxicity in vitro using STZ-treated INS-1 cells and in vivo using an STZ-induced type 2 diabetic rat model treated with NOM (200 mg/kg, orally) for 4 weeks. NOM significantly reduced blood glucose levels and mitigated cytotoxicity associated with black seed extract, both in vitro and in vivo, without evident toxicity (as assessed by body weight, organ indices, and serum biochemistry) at high doses in mice. Gene expression analysis (RT-qPCR) indicated regulation of the intrinsic apoptotic pathway as a potential mechanism. Histopathology supported these findings. Overall, NOM demonstrated effective glucose-lowering potential with reduced toxicity, highlighting the synergistic benefits of combining medicinal herbs.
{"title":"Antidiabetic effects of a polyherbal formulation of Nigella sativa, Origanum vulgare, and Malus asiatica in STZ-induced type 2 diabetic rats","authors":"Mingming Bao , Dezhi Yang , Qiburi Qiburi , Meng He , Temuqile Temuqile , Huricha Baigude","doi":"10.1016/j.jff.2025.107111","DOIUrl":"10.1016/j.jff.2025.107111","url":null,"abstract":"<div><div><em>Nigella sativa</em>, <em>Origanum vulgare</em>, and <em>Malus asiatica</em> are traditionally used for gastrointestinal and metabolic health. A polyherbal formulation combining these herbs (NOM) has been employed as a folk remedy for diabetes, yet its efficacy and toxicity remain underexplored. This study identified bioactive compounds in NOM via UPLC-qTOF MS and assessed antidiabetic effects and cytotoxicity in vitro using STZ-treated INS-1 cells and in vivo using an STZ-induced type 2 diabetic rat model treated with NOM (200 mg/kg, orally) for 4 weeks. NOM significantly reduced blood glucose levels and mitigated cytotoxicity associated with black seed extract, both in vitro and in vivo, without evident toxicity (as assessed by body weight, organ indices, and serum biochemistry) at high doses in mice. Gene expression analysis (RT-qPCR) indicated regulation of the intrinsic apoptotic pathway as a potential mechanism. Histopathology supported these findings. Overall, NOM demonstrated effective glucose-lowering potential with reduced toxicity, highlighting the synergistic benefits of combining medicinal herbs.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107111"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107116
Nevin Sanlier , Ezgi Nur Cinar
Black aronia or chokeberry (Aronia melanocarpa L.) is a shrub plant of the family Rosaceae. Its fresh fruits are rarely consumed due to their bitter taste from high polyphenol content. However, thanks to bioactive components such as proanthocyanidins, anthocyanins, phenolic acids, flavonols, and flavanols, black aronia has positive effects on health and chronic diseases including cardiovascular disease, obesity, and diabetes. It has also been shown to improve insulin sensitivity, lipid profiles, blood pressure, and inflammatory markers. Compared to other berries, it has higher total polyphenol and anthocyanin content and stronger antioxidant capacity. Thus, it may protect against some cancers and slow aging by reducing cellular damage. The juice, pomace, and leaf extracts also show potential health benefits. Although black aronia consumption may positively affect human health, more comprehensive clinical studies are needed to determine clear causal relationships. This review presents its bioactive components and health effects to guide future research.
{"title":"Aronia Berry (Aronia melanocarpa L.) as a Bioactive Treasure: Insights into Its Health-Promoting Effects","authors":"Nevin Sanlier , Ezgi Nur Cinar","doi":"10.1016/j.jff.2025.107116","DOIUrl":"10.1016/j.jff.2025.107116","url":null,"abstract":"<div><div>Black aronia or chokeberry (<em>Aronia melanocarpa</em> L.) is a shrub plant of the family <em>Rosaceae</em>. Its fresh fruits are rarely consumed due to their bitter taste from high polyphenol content. However, thanks to bioactive components such as proanthocyanidins, anthocyanins, phenolic acids, flavonols, and flavanols, black aronia has positive effects on health and chronic diseases including cardiovascular disease, obesity, and diabetes. It has also been shown to improve insulin sensitivity, lipid profiles, blood pressure, and inflammatory markers. Compared to other berries, it has higher total polyphenol and anthocyanin content and stronger antioxidant capacity. Thus, it may protect against some cancers and slow aging by reducing cellular damage. The juice, pomace, and leaf extracts also show potential health benefits. Although black aronia consumption may positively affect human health, more comprehensive clinical studies are needed to determine clear causal relationships. This review presents its bioactive components and health effects to guide future research.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107116"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107118
Yihong Zeng , Jin Wang , Lixia Zhang , Hua Xiao , Liye Zhu , Xiaoyi Wang , Wentao Gu , Min Xu , Ye Han , Shuo Wang
Research on aging and age-related diseases holds positive significance for the promotion of healthy aging. This study evaluated the positive effects of Bifidobacterium breve NKU BB 1–13 on D-galactose-induced aged mice and their colon and heart tissues. Bifidobacterium breve NKU BB 1–13 significantly alleviated pathological phenotypes in the hearts and colons of aged mice while improving colonic, cardiac, and serum-related secretory phenotypes. Notably, Bifidobacterium breve inhibits cardiac IGF1R signaling and its associated pathways; enhances intestinal barrier protein expression and activates the colonic Nrf2-Keap1 pathway; and modulates improvements in gut microbiota and blood metabolism. Correlation analysis indicates that Bifidobacterium breve NKU BB 1–13 may alleviate age-related cardiac dysfunction by improving colonic aging and modulating gut microbiota to influence blood metabolites.
{"title":"Bifidobacterium breve NKU BB 1–13 alleviates age-related cardiac dysfunction by improving colon aging and modulating gut microbiota to influence blood metabolites","authors":"Yihong Zeng , Jin Wang , Lixia Zhang , Hua Xiao , Liye Zhu , Xiaoyi Wang , Wentao Gu , Min Xu , Ye Han , Shuo Wang","doi":"10.1016/j.jff.2025.107118","DOIUrl":"10.1016/j.jff.2025.107118","url":null,"abstract":"<div><div>Research on aging and age-related diseases holds positive significance for the promotion of healthy aging. This study evaluated the positive effects of <em>Bifidobacterium breve</em> NKU BB 1–13 on D-galactose-induced aged mice and their colon and heart tissues. <em>Bifidobacterium breve</em> NKU BB 1–13 significantly alleviated pathological phenotypes in the hearts and colons of aged mice while improving colonic, cardiac, and serum-related secretory phenotypes. Notably, <em>Bifidobacterium breve</em> inhibits cardiac <em>IGF1R</em> signaling and its associated pathways; enhances intestinal barrier protein expression and activates the colonic Nrf2-Keap1 pathway; and modulates improvements in gut microbiota and blood metabolism. Correlation analysis indicates that <em>Bifidobacterium breve</em> NKU BB 1–13 may alleviate age-related cardiac dysfunction by improving colonic aging and modulating gut microbiota to influence blood metabolites.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107118"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107122
Yuan-heng Huang , Fei-Zhang Qin , Ri-rong Meng , Qing Yang , Zu-dong Xu , Si-rui Mo , Xi Lin , Meng-chen Yu , Xue-jiao Li , Yao-sheng Wu , Jie-mei Ye
This study investigates the protective effects of Liupao Tea (LPT) in ulcerative colitis (UC). Using network pharmacology and molecular docking, potential therapeutic targets of LPT were identified, focusing on inflammation and intestinal barrier function. In a mouse model of UC, LPT alleviated disease symptoms, including body weight loss and inflammation, and improved colonic histology. It also suppressed pro-inflammatory cytokines and enhanced the expression of tight junction proteins, indicating restoration of the intestinal barrier. Transcriptomic analysis revealed the modulation of immune, inflammatory, and metabolic pathways, particularly the AMP-activated protein kinase(AMPK) and inflammatory bowel disease signaling pathways. These results suggest that LPT mitigates colonic inflammation and strengthens the intestinal barrier, supporting its potential as a functional food for promoting intestinal health.
{"title":"Liupao tea attenuates ulcerative colitis through modulation of inflammation and intestinal barrier function","authors":"Yuan-heng Huang , Fei-Zhang Qin , Ri-rong Meng , Qing Yang , Zu-dong Xu , Si-rui Mo , Xi Lin , Meng-chen Yu , Xue-jiao Li , Yao-sheng Wu , Jie-mei Ye","doi":"10.1016/j.jff.2025.107122","DOIUrl":"10.1016/j.jff.2025.107122","url":null,"abstract":"<div><div>This study investigates the protective effects of Liupao Tea (LPT) in ulcerative colitis (UC). Using network pharmacology and molecular docking, potential therapeutic targets of LPT were identified, focusing on inflammation and intestinal barrier function. In a mouse model of UC, LPT alleviated disease symptoms, including body weight loss and inflammation, and improved colonic histology. It also suppressed pro-inflammatory cytokines and enhanced the expression of tight junction proteins, indicating restoration of the intestinal barrier. Transcriptomic analysis revealed the modulation of immune, inflammatory, and metabolic pathways, particularly the AMP-activated protein kinase(AMPK) and inflammatory bowel disease signaling pathways. These results suggest that LPT mitigates colonic inflammation and strengthens the intestinal barrier, supporting its potential as a functional food for promoting intestinal health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107122"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107125
Francesco Crudo , Dženeta Dedić , Giorgia Del Favero , Natalia Castejón
Microalgae are considered a sustainable source of essential lipids, including health-promoting polyunsaturated fatty acids (PUFAs); however, their role in supporting intestinal health is still poorly understood. This study evaluated the effects of lipid extracts from Microchloropsis gaditana and Tisochrysis lutea on Caco-2 intestinal cell monolayers and their ability to mitigate damage caused by the mycotoxin deoxynivalenol (DON). The two species showed distinct fatty acid profiles, rich in different PUFAs. T. lutea lipids impaired barrier integrity, reducing transepithelial electrical resistance (TEER) and increasing paracellular permeability. In contrast, M. gaditana lipids enhanced TEER, upregulated tight junction (TJ) proteins claudin-4 and ZO-1, improved TJ co-localization, and reversed DON-induced barrier disruption. These findings suggest M. gaditana lipids may support intestinal barrier function and protect against dietary toxins. Future investigations to elucidate the molecular mechanisms involved and validate these effects in vivo will help fully harness the potential of M. gaditana lipids for intestinal health.
{"title":"Potential of microalgal lipids to prevent intestinal barrier disruption: A case study exploring the response of Caco-2 cells to the food contaminant deoxynivalenol","authors":"Francesco Crudo , Dženeta Dedić , Giorgia Del Favero , Natalia Castejón","doi":"10.1016/j.jff.2025.107125","DOIUrl":"10.1016/j.jff.2025.107125","url":null,"abstract":"<div><div>Microalgae are considered a sustainable source of essential lipids, including health-promoting polyunsaturated fatty acids (PUFAs); however, their role in supporting intestinal health is still poorly understood. This study evaluated the effects of lipid extracts from <em>Microchloropsis gaditana</em> and <em>Tisochrysis lutea</em> on Caco-2 intestinal cell monolayers and their ability to mitigate damage caused by the mycotoxin deoxynivalenol (DON). The two species showed distinct fatty acid profiles, rich in different PUFAs. <em>T. lutea</em> lipids impaired barrier integrity, reducing transepithelial electrical resistance (TEER) and increasing paracellular permeability. In contrast, <em>M. gaditana</em> lipids enhanced TEER, upregulated tight junction (TJ) proteins claudin-4 and ZO-1, improved TJ co-localization, and reversed DON-induced barrier disruption. These findings suggest <em>M. gaditana</em> lipids may support intestinal barrier function and protect against dietary toxins. Future investigations to elucidate the molecular mechanisms involved and validate these effects <em>in vivo</em> will help fully harness the potential of <em>M. gaditana</em> lipids for intestinal health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107125"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107097
Shuwen Yao , Min Zhang , Qinlei Yu , Liping Xu , Xiangyun Yan , Wenjuan Chen , Chengyao Jiang , Yanjie Chen , Kedi Xi , Yu Dai , Shushu Li , Shuping Han , Xiaohui Chen
{"title":"Corrigendum to “Immunoglobulin-derived peptide MEANP1 of human Milk in the protection against experimental necrotizing Enterocolitis via IκB/ NF-κB pathway” [J. Funct. Foods 129 (2025) 106826]","authors":"Shuwen Yao , Min Zhang , Qinlei Yu , Liping Xu , Xiangyun Yan , Wenjuan Chen , Chengyao Jiang , Yanjie Chen , Kedi Xi , Yu Dai , Shushu Li , Shuping Han , Xiaohui Chen","doi":"10.1016/j.jff.2025.107097","DOIUrl":"10.1016/j.jff.2025.107097","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107097"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107126
Jingwei Wu , Zhuoting Zhang , Hanglian Lan , Ting Sun , Zhihui Li , Weilian Hung , Hangyu Hu , Zhennai Yang , Jian Zhang
Exopolysaccharides (EPSs) produced by lactic acid bacteria (LAB) have been extensively studied, but the potential postbiotic activities of the EPSs are not well characterized. A probiotic strain of Lacticaseibacillus paracasei K56 previously characterized by strong postbiotic activities was investigated by response surface analysis for production of an EPS, designated K56-EPS, and by testing EPS for anti-inflammatory effects in a LPS-induced RAW264.7 macrophage inflammation model. The optimal protocol for EPS production (76.27 mg/L) in skim milk employed 8.7 % (w/w) inoculum for 34.2 h fermentation at 33.9 °C, followed by extraction with 6 % (w/v) TCA and treatment of the culture supernatant with 4 volumes of ethanol at 4 °C for 24 h. The chromatographically purified K56-EPS had a monosaccharide composition of rhamnose, glucosamine hydrochloride, galactose, and glucose in a molar ratio of 0.387:0.053:0.188:0.371, with a molecular weight of 3.39 × 105 Da. Furthermore, K56-EPS (200 μg/mL) effectively suppressed expression of key genes within the TLR4/ NF-κB signaling pathway and inhibited the nuclear translocation of the NF-κB p65 protein to interrupt transcriptional activation of inflammatory mediators. Higher dose of K56-EPS (400 μg/mL) was shown to significantly attenuate phagocytosis, reduce acid phosphatase (ACP) activity, decrease nitric oxide (NO) release, and downregulate TNF-α, IL-6, IL-1β, and IL-10 cytokine levels (p < 0.05). Therefore, K56-EPS demonstrated prominent in vitro anti-inflammatory activity with significance as a potential novel postbiotic of LAB for applications in functional dairy foods.
{"title":"Response surface analysis and anti-inflammatory activity of a potential postbiotic exopolysaccharide produced by probiotic Lacticaseibacillus paracasei K56","authors":"Jingwei Wu , Zhuoting Zhang , Hanglian Lan , Ting Sun , Zhihui Li , Weilian Hung , Hangyu Hu , Zhennai Yang , Jian Zhang","doi":"10.1016/j.jff.2025.107126","DOIUrl":"10.1016/j.jff.2025.107126","url":null,"abstract":"<div><div>Exopolysaccharides (EPSs) produced by lactic acid bacteria (LAB) have been extensively studied, but the potential postbiotic activities of the EPSs are not well characterized. A probiotic strain of <em>Lacticaseibacillus paracasei</em> K56 previously characterized by strong postbiotic activities was investigated by response surface analysis for production of an EPS, designated K56-EPS, and by testing EPS for anti-inflammatory effects in a LPS-induced RAW264.7 macrophage inflammation model. The optimal protocol for EPS production (76.27 mg/L) in skim milk employed 8.7 % (<em>w</em>/w) inoculum for 34.2 h fermentation at 33.9 °C, followed by extraction with 6 % (<em>w</em>/<em>v</em>) TCA and treatment of the culture supernatant with 4 volumes of ethanol at 4 °C for 24 h. The chromatographically purified K56-EPS had a monosaccharide composition of rhamnose, glucosamine hydrochloride, galactose, and glucose in a molar ratio of 0.387:0.053:0.188:0.371, with a molecular weight of 3.39 × 10<sup>5</sup> Da. Furthermore, K56-EPS (200 μg/mL) effectively suppressed expression of key genes within the TLR4/ NF-κB signaling pathway and inhibited the nuclear translocation of the NF-κB p65 protein to interrupt transcriptional activation of inflammatory mediators. Higher dose of K56-EPS (400 μg/mL) was shown to significantly attenuate phagocytosis, reduce acid phosphatase (ACP) activity, decrease nitric oxide (NO) release, and downregulate TNF-α, IL-6, IL-1β, and IL-10 cytokine levels (<em>p</em> < 0.05). Therefore, K56-EPS demonstrated prominent in vitro anti-inflammatory activity with significance as a potential novel postbiotic of LAB for applications in functional dairy foods.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107126"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107080
Ana M. Nájar , Soledad Pérez-Sánchez , Carmen del Río , Carmen Domínguez , Cristina López Azcárate , Reyes de Torres , Marcel Lamana-Vallverdú , Marina Romero-Bernal , Ángela González-Díaz , María de la Luz Cádiz-Gurrea , Francisco Javier Leyva-Jiménez , Álvaro Fernández-Ochoa , Antonio León , Joan Montaner
{"title":"Corrigendum to “Dietary supplementation with polyphenol-rich Salicornia ramosissima extracts: Assessing safety, efficacy, and impact on cardiovascular health biomarkers in healthy volunteers” [J. Funct. Foods 122 (2024) 106539]","authors":"Ana M. Nájar , Soledad Pérez-Sánchez , Carmen del Río , Carmen Domínguez , Cristina López Azcárate , Reyes de Torres , Marcel Lamana-Vallverdú , Marina Romero-Bernal , Ángela González-Díaz , María de la Luz Cádiz-Gurrea , Francisco Javier Leyva-Jiménez , Álvaro Fernández-Ochoa , Antonio León , Joan Montaner","doi":"10.1016/j.jff.2025.107080","DOIUrl":"10.1016/j.jff.2025.107080","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107080"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jff.2025.107113
Changchang Fan , Yi You , Jinpeng Yang , Jiaxin Zhu , Kaibo Lv , Zhanbing Ma , Qiong Wang
Tannic acid (TA) demonstrates therapeutic potential for gastroenteritis, but its efficacy against ulcerative colitis (UC) remains unclear. This study evaluated the protective effects of TA against dextran sulfate sodium (DSS)-induced murine colitis. Mice were administered TA (20, 40, or 80 mg/kg) or sulfasalazine (SASP). TA treatment significantly ameliorated colitis severity, as demonstrated by improved body weight recovery, reduced disease activity index (DAI), and attenuated colon shortening. Mechanistically, TA suppressed oxidative stress and inhibited the NF-κB signaling pathway, thereby reducing inflammatory responses. Additionally, TA enhanced intestinal barrier function through increased expression of key tight junction proteins. Furthermore, TA administration dose-dependently remodeled the gut microbiota, with low and medium doses (20 and 40 mg/kg) exhibiting efficacy comparable or superior to SASP. These findings indicate that TA ameliorates DSS-induced colitis through synergistic antioxidant, anti-inflammatory, and microbiota–modulatory actions, highlighting its potential as a natural therapeutic or adjunctive agent for UC.
{"title":"Tannic acid attenuate DSS-induced ulcerative colitis in mice via Antioxidation, anti-inflammation and microbiota regulation","authors":"Changchang Fan , Yi You , Jinpeng Yang , Jiaxin Zhu , Kaibo Lv , Zhanbing Ma , Qiong Wang","doi":"10.1016/j.jff.2025.107113","DOIUrl":"10.1016/j.jff.2025.107113","url":null,"abstract":"<div><div>Tannic acid (TA) demonstrates therapeutic potential for gastroenteritis, but its efficacy against ulcerative colitis (UC) remains unclear. This study evaluated the protective effects of TA against dextran sulfate sodium (DSS)-induced murine colitis. Mice were administered TA (20, 40, or 80 mg/kg) or sulfasalazine (SASP). TA treatment significantly ameliorated colitis severity, as demonstrated by improved body weight recovery, reduced disease activity index (DAI), and attenuated colon shortening. Mechanistically, TA suppressed oxidative stress and inhibited the NF-κB signaling pathway, thereby reducing inflammatory responses. Additionally, TA enhanced intestinal barrier function through increased expression of key tight junction proteins. Furthermore, TA administration dose-dependently remodeled the gut microbiota, with low and medium doses (20 and 40 mg/kg) exhibiting efficacy comparable or superior to SASP. These findings indicate that TA ameliorates DSS-induced colitis through synergistic antioxidant, anti-inflammatory, and microbiota–modulatory actions, highlighting its potential as a natural therapeutic or adjunctive agent for UC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107113"},"PeriodicalIF":4.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-22DOI: 10.1016/j.jff.2025.107112
Nourhan M. Abd El-Aziz , Marwa R. Elbakatoshy , Ebtehal A. Farrage , Oscar Zannou , Reza Tahergorabi , Ayman M. Khalifah , Majid Aminzare , Mohamed G. Shehata
This study investigated the protective effects of Matcha extract against metabolic and organ issues caused by high-fat and high-sugar diets (HFSD) in rats. Matcha showed strong antioxidant activity, with phenolic and flavonoid contents measuring 238.25 mg/g and 60.81 mg/g, respectively. Rats fed on the HFSD gained more weight and had elevated levels of total cholesterol, LDL, triglycerides, and markers for liver and kidney stress, like ALT, AST, and creatinine. Matcha supplementation normalized the weight, cholesterol, LDL, ALT and creatinine. Antioxidant enzymes such as liver SOD were restored, and harmful substances like TBARS and NO were significantly decreased. Gene analysis revealed that beneficial genes were upregulated, while inflammatory markers were downregulated. Tissue analysis showed that Matcha helped protect liver and kidney structures from HFSD damage, reducing inflammation and cellular harm. Overall, the results highlight Matcha's promise as a dietary supplement for combating the metabolic and inflammatory effects of high-fat, high-sugar diets.
{"title":"Matcha mitigates metabolic and inflammatory disturbances induced by high-fat-sucrose diets in rats","authors":"Nourhan M. Abd El-Aziz , Marwa R. Elbakatoshy , Ebtehal A. Farrage , Oscar Zannou , Reza Tahergorabi , Ayman M. Khalifah , Majid Aminzare , Mohamed G. Shehata","doi":"10.1016/j.jff.2025.107112","DOIUrl":"10.1016/j.jff.2025.107112","url":null,"abstract":"<div><div>This study investigated the protective effects of Matcha extract against metabolic and organ issues caused by high-fat and high-sugar diets (HFSD) in rats. Matcha showed strong antioxidant activity, with phenolic and flavonoid contents measuring 238.25 mg/g and 60.81 mg/g, respectively. Rats fed on the HFSD gained more weight and had elevated levels of total cholesterol, LDL, triglycerides, and markers for liver and kidney stress, like ALT, AST, and creatinine. Matcha supplementation normalized the weight, cholesterol, LDL, ALT and creatinine. Antioxidant enzymes such as liver SOD were restored, and harmful substances like TBARS and NO were significantly decreased. Gene analysis revealed that beneficial genes were upregulated, while inflammatory markers were downregulated. Tissue analysis showed that Matcha helped protect liver and kidney structures from HFSD damage, reducing inflammation and cellular harm. Overall, the results highlight Matcha's promise as a dietary supplement for combating the metabolic and inflammatory effects of high-fat, high-sugar diets.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107112"},"PeriodicalIF":4.0,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145569126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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