Journal of Functional Foods最新文献

{"title":"Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus","authors":"Bárbara Cabral ,&nbsp;Ony Araújo Galdino ,&nbsp;Iago de Souza Gomes ,&nbsp;Jovelina Samara Ferreira Alves ,&nbsp;José Ivan Marques ,&nbsp;Karla Simone Costa de Souza ,&nbsp;Rodrigo Moreira da Silva ,&nbsp;Bento João Abreu ,&nbsp;Norberto Peporine Lopes ,&nbsp;Silvana Maria Zucolotto ,&nbsp;Adriana Augusto de Rezende","doi":"10.1016/j.jff.2024.106638","DOIUrl":"10.1016/j.jff.2024.106638","url":null,"abstract":"<div><div>The study investigated the potential benefits of passion fruit peel extracts (PFAE and PFHE), derived from <em>Passiflora edulis</em> fo. <em>flavicarpa</em>, for Type 1 <em>Diabetes mellitus</em> (T1DM). Extracts were produced using eco-friendly solvents and evaluated in a T1DM chronic model. Acute toxicity tests showed the extracts (2000 mg/kg, orally) were safe. Liquid chromatography coupled to triple quadrupole mass spectrometry (LC-QqQ-MS/MS) identified five C-glycosylated flavonoids (vicenin-2, orientin, isoorientin, vitexin, isovitexin) in the extracts. Adjuvant treatment with extracts alongside insulin significantly improved glycemic control over 60 days compared to insulin alone (<em>p</em> &lt; 0.05). Furthermore, extracts protected against renal fibrosis and maintenance of the levels of inflammatory markers, such as myeloperoxidase, in the hearts and kidneys of diabetic rats. These findings suggest passion fruit peel extracts could enhance long-term T1DM management by improving glycemic control and preventing organ damage, potentially inspiring the development of new food or pharmaceutical products with beneficial actions for T1DM.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106638"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive study of Tilapia skin collagen peptide on ileal injury and intestinal flora in rats induced by high altitude hypoxia","authors":"Jingyi Wang,&nbsp;Hao Wang,&nbsp;Chunxia Li,&nbsp;Xiaojuan Zhang,&nbsp;Jin Liu,&nbsp;Yanzhou Hu,&nbsp;Ping Qian","doi":"10.1016/j.jff.2024.106634","DOIUrl":"10.1016/j.jff.2024.106634","url":null,"abstract":"<div><div>Acute high-altitude hypoxia is typically linked to intestinal injury and dysbiosis of the gut microbiota. Thus, the aims of this study were to investigate the effects of <em>Tilapia</em> skin collagen peptide (CP) on inflammatory response, antioxidant systems, intestinal barrier function, and intestinal flora in rats exposed to high altitude hypoxia condition. Additionally, a Nano liquid chromatography-tandem mass spectrometry (nano LC-MS/MS) and virtual screening were employed to identify specific peptides that could be functionally significant. The results showed that CP could reduce the Disease active index (DAI), increase the mRNA expression level of tight junction protein, and reduce the content of D-lactic acid (D-LA) and Diamine oxidase (DAO) in the serum of rats, and thus alleviate the mechanical injury of intestinal mucosa induced by hypoxia. In addition, CP improved hypoxia-induced intestinal inflammation by significantly down-regulating pro-inflammatory cytokines (IL-6, IL-12, TNF-α and CRP). Furthermore, CP significantly up-regulated the an tioxidant enzymes SOD and GSH-Px and down-regulated MDA in the serum of rats, and improved hypoxia-induced oxidative stress. 16S rDNA sequencing of the intestinal flora revealed that CP significantly reduced the abundance of the pathogenic bacterium <em>Escherichia</em>, increased the abundance of the beneficial bacterium <em>Limosilactobacillu</em>, and significantly increased the levels of acetic acid, isobutyric acid, and isovaleric acid in feces. Five potential anti-inflammatory peptides were identified including AGFF, FGLGFF, LGLF, LGFL and LFGF by nano LC-MS/MS technology and virtual screening. Molecular docking analysis revealed that these screened peptides can competitively interrupt the formation of TNF-α. Consequently, CP effectively alleviates hypoxia-induced intestinal barrier injury in rats by reducing inflammation, oxidative stress, and modifying intestinal flora and its metabolites.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106634"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional composition, toxicity, and the effects of Parkia biglobosa on the metabolic, somatic and oxidative parameters related to liver and kidney function of obese rats","authors":"Mirela Gouveia-Nhanca ,&nbsp;Maria Luiza Rolim Bezerra ,&nbsp;Yuri Mangueira do Nascimento ,&nbsp;Evandro Ferreira da Silva ,&nbsp;Josean Fechine Tavares ,&nbsp;Gonçalo Mendes da Conceição ,&nbsp;Rubens Teixeira de Queiroz ,&nbsp;Luis António Tavares ,&nbsp;Adriano Francisco Alves ,&nbsp;Jailane de Souza Aquino","doi":"10.1016/j.jff.2024.106479","DOIUrl":"10.1016/j.jff.2024.106479","url":null,"abstract":"<div><h3>Background</h3><div>The pathophysiology of obesity is associated with somatic, metabolic and oxidative changes which can also compromise renal and hepatic function. Treatment of this condition involves dietary intervention, including incorporating foods rich in bioactive compounds such as <em>Parkia biglobosa</em>. This legume is rich in fibres and phenolic compounds such as 3,4-dihydroxybenzoic acid, catechin, and myricetin that can play a significant role in the adjuvant treatment of obesity. Thus, we evaluated the nutritional composition, toxicity, and the effects of <em>Parkia biglobosa</em> on metabolic, somatic and oxidative parameters, as well as the liver and kidney function of obese rats.</div></div><div><h3>Methods</h3><div><em>Parkia biglobosa</em> pulp was initially characterised and evaluated for its toxicity. Then, male Wistar rats were randomised into groups: healthy (HG); obese (OG); healthy (HPB) and obese (OPB) both treated with <em>Parkia biglobosa</em> (400 mg/kg). Somatic and biochemical parameters; triglyceride, cholesterol and total fat in faeces and liver; oxidative and histological parameters in the liver and kidney were all analysed. <em>Results</em>: <em>Parkia biglobosa</em> intake reduced the adiposity index; improved glucose tolerance, insulin resistance, leptinemia and lipid metabolism parameters, which impacted the minimization of hepatic steatosis and improved oxidative parameters in the kidney and liver in obese rats (OPB). These findings are related to the nutritional composition of this legume, such as the relationship between insoluble and soluble fibres, as well as the phenolic and mineral profile.</div></div><div><h3>Conclusion</h3><div>The set of results showed that <em>Parkia biglobosa</em> had an anti-adiposity effect, improved biochemical including hormonal parameters and reversed the changes in hepatic and renal markers in obesity-induced rats.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106479"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egg yolk hydrolysate shows osteogenic activity in MC3T3-E1 osteoblastic cells","authors":"Ilekuttige Priyan Shanura Fernando,&nbsp;Pauline Duffuler,&nbsp;Jianping Wu","doi":"10.1016/j.jff.2024.106633","DOIUrl":"10.1016/j.jff.2024.106633","url":null,"abstract":"<div><div>There is growing interest in natural bioactive compounds for bone health, with egg yolk peptides showing promise owing to their osteogenic properties. However, previously reported extraction and purification methods are costly and time-consuming. This study explored the osteogenic properties of water-soluble egg yolk peptide fractions obtained using methods that are easily scalable for industrial production. Three different fractions were prepared: FA, water-soluble egg yolk fraction; FB, salt-soluble egg yolk fraction; FC, salt-soluble hydrolyzed egg yolk fraction. Effects of fractions were evaluated on osteoblastogenesis. FC, obtained via Protease M and Lipase AY digestion, stood out compared to FA and FB, demonstrating improved MC3T3-El proliferation, RUNX2 production, Akt phosphorylation, and osteoid mineralization. FC contains phosvitin and vitellogenin. The &lt;3 kDa subfraction of FC obtained by ultrafiltration indicated a higher osteogenic potential in MC3T3-E1 preosteoblasts. These findings indicate that the egg yolk hydrolysate obtained by the FC method could be a promising source for formulating functional foods that enhance bone health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106633"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm","authors":"Nosheen Malik ,&nbsp;Hammad Murtaza ,&nbsp;Waseem Ashraf ,&nbsp;Muhammad Fawad Rasool ,&nbsp;Farhan Siddique ,&nbsp;Maryam Bashir ,&nbsp;Tanveer Ahmad ,&nbsp;Faleh Alqahtani ,&nbsp;Imran Imran","doi":"10.1016/j.jff.2024.106641","DOIUrl":"10.1016/j.jff.2024.106641","url":null,"abstract":"<div><div>The active avoidance paradigm is a reliable tool for the assessment of associative learning/memory. Nutritional manipulation is an emerging approach for the improvisation of brain health. <em>Syzygium cumini</em> (SC) fruit with enriched phytoconstituents, was investigated in varied concentrations on the learning/memory of scopolamine-induced amnesic mice through active-avoidance protocol. Chemical characterization by UHPLC-MS and molecular docking were performed for the identification of phytoconstituents and their action on possible targets. Our results revealed that SC-supplemented mice performed well as compared to amnesic group, with significant increase in the percentage avoidance and decrease in the latency. The identified phytoconstituents may enhance the cognitive performance in treated groups because of their antioxidant potential. Moreover, <em>in-silico</em> studies demonstrated good binding interactions with cholinesterase enzyme possibly inhibiting it and augmenting cholinergic activity in brain. In conclusion, SC dilutions improved cognitive performance in amnesic mice possibly due to antioxidant and anticholinesterase effects exerted by phyto-compounds.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106641"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro antidiabetic activity of facheiro (Pilosocereus pachycladus) mucilage and its effects on glycaemic, renal and hepatic parameters in obese rats","authors":"Fabrícia de Souza Ferreira ,&nbsp;Hassler Clementino Cavalcante ,&nbsp;Larissa Maria Gomes Dutra ,&nbsp;Adriano Francisco Alves ,&nbsp;Stephson Andriola Almeida Gonçalves ,&nbsp;Tatiana Colombo Pimentel ,&nbsp;Carlos Eduardo Barão ,&nbsp;Marcos dos Santos Lima ,&nbsp;Alana Natalícia Vasconcelos de Araújo ,&nbsp;Januse Millia Dantas de Araújo ,&nbsp;Kamila Sabino Batista ,&nbsp;Jailane de Souza Aquino ,&nbsp;Angela Maria Tribuzy de Magalhães Cordeiro","doi":"10.1016/j.jff.2024.106575","DOIUrl":"10.1016/j.jff.2024.106575","url":null,"abstract":"<div><div>We evaluated the <em>in vitro</em> antidiabetic activity of facheiro (<em>Pilosocereus pachycladus</em>) mucilage and its effects on glycaemic, renal and hepatic parameters in obese rats. First, <em>in vitro</em> antidiabetic activity was analysed through the inhibition of α-amylase and α-glucosidase. Then, the acute toxicity of mucilage was evaluated in Wistar rats for 14 days. After, an experiment to evaluate the effects of mucilage on obesity was conducted with 30 male Wistar rats randomised into three groups: healthy (HG); obese (OG); and obese treated with facheiro mucilage (FOG) by gavage (200 mg/kg). The HG received commercial diet and the OG and FOG received a cafeteria diet for 12 weeks. Facheiro mucilage showed antidiabetic activity <em>in vitro</em> by reducing the α-amylase (64.15 ± 3.86 %) and α-glucosidase activity (86.43 ± 1.09 %), without signs of acute toxicity <em>in vivo</em>. Mucilage treatment reduced insulinemia (OG = 29.70 ± 4.52 µIU/mL vs. FOG = 14.04 ± 5.08 µIU/mL, p = 0.01, effect size: 3.25), homeostasis assessment model (OG = 0.99 ± 0.12, FOG = 0.76 ± 0.18, p = 0.03, effect size: 1.50), uric acid (OG = 6.65 ± 1.63 mg/dL vs. FOG = 4.07 ± 0.65 mg/dL, p = 0.0001, effect size: 2.07), creatinine (OG = 0.90 ± 0.08 mg/dL vs. FOG = 1.05 ± 0.15 mg/dL, p = 0.0001, effect size: 1.24), alanine transaminase (OG = 29.70 ± 4.52 IU/L vs. FOG = 14.05 ± 5.08 IU/L, p = 0.0001, effect size: 3.25), aspartate transaminase (OG = 58.55 ± 7.10 IU/L vs. FOG = 22.35 ± 3.61 IU/L, p = 0.0001, effect size: 6.42) and the hepatic steatosis in the FOG compared to the OG. Mucilage intake increased the total concentrations of organic acids and sugars in renal and hepatic tissues of the FOG when compared to the OG. However, overall, it did not alter the murinometric parameters. Our results suggest that facheiro mucilage had antidiabetic activity <em>in vitro</em>, which corroborated the improvement of insulinemia and insulin resistance in FOG rats; in addition, it showed renoprotective and hepatoprotective effects, highlighting a reversal in the severity of hepatic steatosis in obese rats.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106575"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of 18β-Glycyrrhetinic acid in pulmonary arterial hypertension by integrating network pharmacology and experimental validation","authors":"Wenli Yang ,&nbsp;Long Ma ,&nbsp;Meidong Si ,&nbsp;Fang Zhao ,&nbsp;Ru Zhou","doi":"10.1016/j.jff.2024.106605","DOIUrl":"10.1016/j.jff.2024.106605","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary arterial hypertension (PAH) is characterized by elevated pressure in the pulmonary arteries and can result in right heart failure and possible death.18β-Glycyrrhetinic acid (18β-GA), a beneficial substance found in licorice, shows great potential for medicinal use. Through network pharmacology and experimental validation, this study examined the probable mechanism of 18β-GA in treating PAH.</div></div><div><h3>Methods</h3><div>The analysis of the potential pharmacological activities of 18β-GA was conducted using the network pharmacology method. The network of interactions between proteins was created by identifying shared targets of 18β-GA and PAH across multiple databases. Pathway enrichment was then conducted to determine the key targets. Validation of the interactions between 18β-GA and key targets was performed by molecular docking. Ultimately, we confirmed the modes of operation by utilizing a monocrotaline (MCT)--induced PAH model in rats.</div></div><div><h3>Results</h3><div>A total of 197 potential targets for 18β-GA and 1713 potential targets associated with PAH were successfully identified. Of these, 79 targets were identified as common to both 18β-GA and PAH. Through the analysis of the PPI network, identified key targets, including IL6, AKT1, ALB, BCL2, NFKB1, IL1B, SRC, MMP9, PPARG, MAPK3, PTGS2, ESR1, TNF, CTNNB1 and CASP3. Furthermore, the analysis of molecular docking indicated that SRC exhibited the highest affinity for 18β-GA. The efficacy of 18β-GA in mitigating the advancement of MCT-induced PAH in rats was proven by in vivo investigations.</div></div><div><h3>Conclusions</h3><div>This study presents initial findings about the molecular mechanism by which 18β-GA exerts its therapeutic effects on PAH. The findings suggest that using 18β-GA for treating PAH may involve the deactivation of SRC and the reduction of oxidative stress.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106605"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection","authors":"Tadanobu Takahashi ,&nbsp;Yuuki Kurebayashi ,&nbsp;Shunsuke Suzuki ,&nbsp;Kobun Konagaya ,&nbsp;Yutaka Narimichi ,&nbsp;Eiji Kobatake ,&nbsp;Hirofumi Fukudome ,&nbsp;Toshiyuki Yamaguchi ,&nbsp;Fumihiko Sakai ,&nbsp;Toshinobu Arai ,&nbsp;Toshihide Kabuki ,&nbsp;Akira Minami ,&nbsp;Hideyuki Takeuchi","doi":"10.1016/j.jff.2024.106656","DOIUrl":"10.1016/j.jff.2024.106656","url":null,"abstract":"<div><div>Orthorubulavirus parotitis, known as the mumps virus (MuV), can cause severe complications, including deafness and reduced fertility in humans. Developing preventive strategies against MuV infections is essential to mitigate these risks. We previously established an effective method for producing a milk-derived sialylglycopeptide (MSGP) concentrate from glycomacropeptide (GMP) in bovine milk using protease treatment. This MSGP concentrate was rich in short glycans containing α2–3 linked sialic acids, resembling the MuV binding receptors, which may contribute to inhibiting MuV infection. Our findings revealed that the MSGP concentrate significantly reduced MuV infection compared to the GMP concentrate. The hemagglutination inhibition of the MSGP concentrate was 2–8 times higher than that of the GMP concentrate, suggesting that the MSGP concentrate inhibits MuV infection by preventing receptor binding. These results highlight the potential of the MSGP concentrate as a food-derived functional material for preventing MuV infections.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106656"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143160773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dried distillers grains on quality of dough and bread","authors":"Cunjian Tu ,&nbsp;Qiang Wang ,&nbsp;Xinhong Liang ,&nbsp;Ning Li ,&nbsp;Ruixiang Zhao ,&nbsp;Lingxia Jiao ,&nbsp;Junjian Ran ,&nbsp;Junchao Huang","doi":"10.1016/j.jff.2024.106629","DOIUrl":"10.1016/j.jff.2024.106629","url":null,"abstract":"<div><div>Dried distillers grains are rich in dietary fiber and protein. Dried distillers grains was added to wheat flour to improve the nutrition and sensory quality of wheat flour staple food. The effects of Dried distillers grains on the thermomechanical properties and rheological properties of wheat flour dough were studied. After the addition of Dried distillers grains, the water absorption and protein weakening degree of the dough increased significantly. Simultaneously, the stability time and formation time decreased significantly. These changes indicate that Dried distillers grains has a substantial influence on the network structure of protein in wheat flour dough and on the gluten strength of the dough. Interestingly, the increase in the elastic modulus (G′) and viscous modulus (G′′) indicates enhanced stability in the dough structure, resulting in reduced fluidity and viscosity. Texture analysis revealed that Dried distillers grains could significantly reduce bread hardness within the 2–8 % range, while also increasing the specific volume of the bread. The sensory score reached its highest point with an 8 % substitution of Dried distillers grains. These results demonstrate that the addition of 2–8 % Dried distillers grains improves the quality of the bread.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106629"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut","authors":"Lulu Meng ,&nbsp;Haishan Xie ,&nbsp;Zhe Li ,&nbsp;Kian Deng Tye ,&nbsp;Ge Fan ,&nbsp;Ting Huang ,&nbsp;Hao Yan ,&nbsp;Xiaomei Tang ,&nbsp;Huijuan Luo ,&nbsp;Xiaomin Xiao","doi":"10.1016/j.jff.2024.106620","DOIUrl":"10.1016/j.jff.2024.106620","url":null,"abstract":"<div><div>This observational study investigated the transfer of maternal gut microbiota to the infant gut through breast milk and its implications for infant gut health. Fecal and breast milk samples were collected from 23 healthy mother-infant pairs, with 11 breast milk samples testing positive for microbial presence. Microbial source tracking revealed that 22.89 % of breast milk microbiota originated from the maternal gut, and 25.64 % of the infant gut microbiota was derived from breast milk. Shared OTUs between the paired maternal gut, breast milk, and infant gut had a median of 109 (range: 61–148). Genera such as <em>Bifidobacterium</em>, <em>Escherichia-Shigella</em>, and <em>Bacteroides</em> were common across the three sites. Comparisons with the sterile milk group (<em>n</em> = 12) indicated a potential role for breast milk microbiota in maternal-infant microbiota transmission. This study highlights breast milk as a significant medium for microbiota transfer and provides a theoretical basis for promoting infant gut health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"124 ","pages":"Article 106620"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}