α-Glucosidase inhibitors like acarbose are widely used oral hypoglycemic agents but often cause gastrointestinal adverse effects. To address this issue, natural inhibitors from fermented foods offer a promising alternative for developing safer drugs. This review synthesizes literature from 2010 to the present (2025) focusing on three aspects: types of inhibitor-containing fermented foods (e.g., dairy, soy, vinegar, tea, wine), isolation and identification techniques (e.g., HPLC, MS), and activity evaluation methods (e.g., PNPG, Caco-2 models). Studies show these inhibitors—including peptides and polyphenols—typically act through reversible mechanisms such as competitive inhibition. Future research should focus on strain screening, process optimization, novel inhibitor discovery, and mechanistic studies to facilitate industrial application and development of functional products.
{"title":"Research progress of α-glucosidase inhibitors from fermented food","authors":"Xinrui Xie , Bangyu Lv , Yuancong Gu , Xingrui Nian , Xinhe Yang","doi":"10.1016/j.jff.2025.107076","DOIUrl":"10.1016/j.jff.2025.107076","url":null,"abstract":"<div><div>α-Glucosidase inhibitors like acarbose are widely used oral hypoglycemic agents but often cause gastrointestinal adverse effects. To address this issue, natural inhibitors from fermented foods offer a promising alternative for developing safer drugs. This review synthesizes literature from 2010 to the present (2025) focusing on three aspects: types of inhibitor-containing fermented foods (e.g., dairy, soy, vinegar, tea, wine), isolation and identification techniques (e.g., HPLC, MS), and activity evaluation methods (e.g., PNPG, Caco-2 models). Studies show these inhibitors—including peptides and polyphenols—typically act through reversible mechanisms such as competitive inhibition. Future research should focus on strain screening, process optimization, novel inhibitor discovery, and mechanistic studies to facilitate industrial application and development of functional products.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107076"},"PeriodicalIF":4.0,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.jff.2025.107085
Xiang Liu , Zhongwei Zhang , Sujin Deng , Limin Zhu , Shuiqing Chen , Chunlin Chen , Changjiu Ji , Zhihong Feng , Lingguang Yang , Yongchao Xie , Peipei Yin
This study investigated the effects of four drying methods (freeze-drying (FD), vacuum-drying (VD), hot air-drying (HD), and sun-drying (SD)) on the phytochemical profile and bioactivities of different parts (leaves, pulps, peels, seeds) of Citrus aurantium. Quantitative analysis revealed that FD significantly (P < 0.05) enhanced the retention of total phenolics (e.g., 25.30 ± 0.65 mg GAE/g), flavanols (0.85 ± 0.02 mg CE/g), flavonols (23.91 ± 0.78 mg RE/g) and condensed tannins (3.39 ± 0.04 mg CE/g) in leaves, concurrently yielding the strongest antioxidant (DPPH IC₅₀: 3.26 ± 0.16 mg/mL; ABTS IC₅₀: 0.81 ± 0.01 mg/mL) activity. Conversely, thermal drying methods (VD, HD) and SD were more suitable for pulps, peels, and seeds. For instance, peels and seeds treated with thermal drying methods exhibited higher anti-α-glucosidase activity significantly (P < 0.05) than FD. UPLC-QTOF-MS/MS identified 14 phenolic and alkaloid compounds, with correlation analyses confirming that phenolic compounds were the primary contributors to the observed bioactivities. This study provides a quantitative basis for selecting optimal drying methods to maximize the bioactivity and utilization of different C. aurantium parts for functional food and pharmaceutical applications
{"title":"Impact of varied drying methods on the phytochemical compounds, and antioxidant, antidiabetic and anti-tyrosinase activities of Citrus aurantium","authors":"Xiang Liu , Zhongwei Zhang , Sujin Deng , Limin Zhu , Shuiqing Chen , Chunlin Chen , Changjiu Ji , Zhihong Feng , Lingguang Yang , Yongchao Xie , Peipei Yin","doi":"10.1016/j.jff.2025.107085","DOIUrl":"10.1016/j.jff.2025.107085","url":null,"abstract":"<div><div>This study investigated the effects of four drying methods (freeze-drying (FD), vacuum-drying (VD), hot air-drying (HD), and sun-drying (SD)) on the phytochemical profile and bioactivities of different parts (leaves, pulps, peels, seeds) of <em>Citrus aurantium</em>. Quantitative analysis revealed that FD significantly (<em>P</em> < 0.05) enhanced the retention of total phenolics (e.g., 25.30 ± 0.65 mg GAE/g), flavanols (0.85 ± 0.02 mg CE/g), flavonols (23.91 ± 0.78 mg RE/g) and condensed tannins (3.39 ± 0.04 mg CE/g) in leaves, concurrently yielding the strongest antioxidant (DPPH IC₅₀: 3.26 ± 0.16 mg/mL; ABTS IC₅₀: 0.81 ± 0.01 mg/mL) activity. Conversely, thermal drying methods (VD, HD) and SD were more suitable for pulps, peels, and seeds. For instance, peels and seeds treated with thermal drying methods exhibited higher anti-α-glucosidase activity significantly (<em>P</em> < 0.05) than FD. UPLC-QTOF-MS/MS identified 14 phenolic and alkaloid compounds, with correlation analyses confirming that phenolic compounds were the primary contributors to the observed bioactivities. This study provides a quantitative basis for selecting optimal drying methods to maximize the bioactivity and utilization of different <em>C. aurantium</em> parts for functional food and pharmaceutical applications</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107085"},"PeriodicalIF":4.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.jff.2025.107087
Young Mi Park , Hak Yong Lee , Dong Yeop Shin , Hai Min Hwang , Sung Hak Chun , Sang Jin Lim , Hye Jeong Yang , Min Jung Kim , Myung-Sunny Kim , Byeongsu Park , Jun Sang Bae , Jae Gon Kim
The COVID-19 pandemic has increased interest in natural products with immune-enhancing properties. Ginger leaf extract (GLE) was investigated for its immunomodulatory effects in immunosuppressed rats. Rutin, a key bioactive compound, was identified using ultra-performance liquid chromatography. Rats received various GLE concentrations, and immune responses were evaluated through hematological, biochemical, cellular, and histological analyses. GLE intake increased white blood cell and lymphocyte counts, enhanced splenocyte proliferation, and elevated splenic natural killer (NK) cell activity. Furthermore, serum pro-inflammatory cytokines (IL-2, IL-12, IFN-γ) and immunoglobulin G levels were significantly increased. Although body, thymus, and spleen weights were unaffected, GLE improved splenic architecture and immune-related mechanisms. These findings demonstrate that GLE enhances immune function by stimulating cytokine production and NK cell activity, suggesting potential immunotherapeutic and anticancer applications.
{"title":"Ginger (Zingiber officinale) leaf extract promotes secretion of cytokines and natural killer cell activity in cyclophosphamide-induced immunosuppressed rats","authors":"Young Mi Park , Hak Yong Lee , Dong Yeop Shin , Hai Min Hwang , Sung Hak Chun , Sang Jin Lim , Hye Jeong Yang , Min Jung Kim , Myung-Sunny Kim , Byeongsu Park , Jun Sang Bae , Jae Gon Kim","doi":"10.1016/j.jff.2025.107087","DOIUrl":"10.1016/j.jff.2025.107087","url":null,"abstract":"<div><div>The COVID-19 pandemic has increased interest in natural products with immune-enhancing properties. Ginger leaf extract (GLE) was investigated for its immunomodulatory effects in immunosuppressed rats. Rutin, a key bioactive compound, was identified using ultra-performance liquid chromatography. Rats received various GLE concentrations, and immune responses were evaluated through hematological, biochemical, cellular, and histological analyses. GLE intake increased white blood cell and lymphocyte counts, enhanced splenocyte proliferation, and elevated splenic natural killer (NK) cell activity. Furthermore, serum pro-inflammatory cytokines (IL-2, IL-12, IFN-γ) and immunoglobulin G levels were significantly increased. Although body, thymus, and spleen weights were unaffected, GLE improved splenic architecture and immune-related mechanisms. These findings demonstrate that GLE enhances immune function by stimulating cytokine production and NK cell activity, suggesting potential immunotherapeutic and anticancer applications.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107087"},"PeriodicalIF":4.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.jff.2025.107086
Carla N. Molina , Nicola Gasparre , Nandika Bandara , Jordi Mañes , Martin G. Scanlon
Bioactive compounds like phenylpropanoids and phenylethanoids, found in adaptogenic roots Rhodiola rosea (RR) and Eleutherococcus senticosus (ES), are commonly used in supplements. Crackers made with pulse protein isolates represent a vehicle to deliver these compounds. This study investigated interactions of RR and ES root powders with protein isolates (pea (PPI), faba bean (FBPI), lentil (LPI) and lupin (LuPI)) and their impact on dough and cracker physicochemical properties. In addition, in vitro bioaccessibility was studied. Root powders significantly increased dough consistency, with RR promoted protein aggregation. In the crackers, a reduced lightness and increased yellowness was shown, particularly with RR. FBPI_control crackers were the hardest and stiffest, while root addition generally softened texture. FTIR revealed that secondary structure changes influenced in vitro bioaccessibility, with β-sheets and protein aggregates limiting and random coil enhancing release of bioactives. Combining adaptogenic roots with pulse proteins is a promising strategy for producing functional high-protein crackers.
{"title":"Protein matrix interactions and adaptogenic bioactive release in high-protein cracker systems enriched with Rhodiola rosea and Eleutherococcus senticosus","authors":"Carla N. Molina , Nicola Gasparre , Nandika Bandara , Jordi Mañes , Martin G. Scanlon","doi":"10.1016/j.jff.2025.107086","DOIUrl":"10.1016/j.jff.2025.107086","url":null,"abstract":"<div><div>Bioactive compounds like phenylpropanoids and phenylethanoids, found in adaptogenic roots <em>Rhodiola rosea</em> (RR) and <em>Eleutherococcus senticosus</em> (ES), are commonly used in supplements. Crackers made with pulse protein isolates represent a vehicle to deliver these compounds. This study investigated interactions of RR and ES root powders with protein isolates (pea (PPI), faba bean (FBPI), lentil (LPI) and lupin (LuPI)) and their impact on dough and cracker physicochemical properties. In addition, <em>in vitro</em> bioaccessibility was studied. Root powders significantly increased dough consistency, with RR promoted protein aggregation. In the crackers, a reduced lightness and increased yellowness was shown, particularly with RR. FBPI_control crackers were the hardest and stiffest, while root addition generally softened texture. FTIR revealed that secondary structure changes influenced <em>in vitro</em> bioaccessibility, with β-sheets and protein aggregates limiting and random coil enhancing release of bioactives. Combining adaptogenic roots with pulse proteins is a promising strategy for producing functional high-protein crackers.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107086"},"PeriodicalIF":4.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to evaluate the redox-related effects of extracts from four emblematic Greek wines – Xinomavro, Agiorgitiko, Assyrtiko, and Malagouzia. Their impact on cell viability and redox homeostasis was examined in HepG2, EA.hy926, and MKN45 cells. All extracts showed similar cytotoxic thresholds in EA.hy926 and MKN45 cells, while in HepG2 cells Xinomavro and Agiorgitiko wine extracts displayed lower thresholds than Assyrtiko and Malagouzia. Regarding redox modulation, Agiorgitiko enhanced antioxidant defenses in all cell lines and reduced lipid peroxidation in MKN45 cells. Xinomavro increased cellular antioxidant arsenal and mitigated lipid and protein oxidation. Assyrtiko and Malagouzia predominantly attenuated oxidative damage across all cell lines, with Assyrtiko further elevating antioxidant activity in EA.hy926 and MKN45 cells. Agiorgitiko and Malagouzia downregulated Nrf2 gene expression in EA.hy926 cells. Overall, these findings suggest that Greek wine extracts can beneficially modulate redox balance and represent promising sources of bioactive antioxidant compounds.
{"title":"The endemic Greek wines Χinomavro, Agiorgitiko, Αssyrtiko, and Malagouzia exert beneficial effects on human cells by upregulating the antioxidant defense mechanisms","authors":"Fotios Tekos , Periklis Vardakas , Zoi Skaperda , Paraskevi-Maria Nechalioti , Κorina Atsopardi , Kyriaki Xiftou , Anastasia Patouna , Maria Gkasdrogka , Aristidis S. Veskoukis , Antonis Giakountis , Konstantinos Poulas , Demetrios Kouretas","doi":"10.1016/j.jff.2025.107088","DOIUrl":"10.1016/j.jff.2025.107088","url":null,"abstract":"<div><div>The aim of this study was to evaluate the redox-related effects of extracts from four emblematic Greek wines – Xinomavro, Agiorgitiko, Assyrtiko, and Malagouzia. Their impact on cell viability and redox homeostasis was examined in HepG2, EA.hy926, and MKN45 cells. All extracts showed similar cytotoxic thresholds in EA.hy926 and MKN45 cells, while in HepG2 cells Xinomavro and Agiorgitiko wine extracts displayed lower thresholds than Assyrtiko and Malagouzia. Regarding redox modulation, Agiorgitiko enhanced antioxidant defenses in all cell lines and reduced lipid peroxidation in MKN45 cells. Xinomavro increased cellular antioxidant arsenal and mitigated lipid and protein oxidation. Assyrtiko and Malagouzia predominantly attenuated oxidative damage across all cell lines, with Assyrtiko further elevating antioxidant activity in EA.hy926 and MKN45 cells. Agiorgitiko and Malagouzia downregulated Nrf2 gene expression in EA.hy926 cells. Overall, these findings suggest that Greek wine extracts can beneficially modulate redox balance and represent promising sources of bioactive antioxidant compounds.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107088"},"PeriodicalIF":4.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jff.2025.107047
Daeun Lee , Seon-Kyung Hwang , Sumin Choo , Byungdoo Hwang , Jun-Hui Song , Soo Ah Jeong , Yeong Hwan Jeong , Myeong Gwan Son , Gi Hyeon Kim , Beong Ou Lim , Hoon Kim , Sung-Kwon Moon
{"title":"Corrigendum to “Propionic acid-rich fermented blueberry supernatant improves DSS-induced colitis symptoms by regulating inflammatory pathways” [J. Funct. Foods 133 (2025) 107013]","authors":"Daeun Lee , Seon-Kyung Hwang , Sumin Choo , Byungdoo Hwang , Jun-Hui Song , Soo Ah Jeong , Yeong Hwan Jeong , Myeong Gwan Son , Gi Hyeon Kim , Beong Ou Lim , Hoon Kim , Sung-Kwon Moon","doi":"10.1016/j.jff.2025.107047","DOIUrl":"10.1016/j.jff.2025.107047","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107047"},"PeriodicalIF":4.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145413033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jff.2025.107046
So Yeon Jeon , Jihoon Lee , Ji-Hyeon Jeon , Juyoung Kim , Yeon-Ju Baek , Min-Koo Choi , Soohyun Sung , Jong Won Kim , Sanghyun Lim , Im-Sook Song
{"title":"Corrigendum to “Effect of a probiotic mixture on the biotransformation and bioavailability of deglycosylated ginsenosides” [J. Funct. Foods 133 (2025) 107015]","authors":"So Yeon Jeon , Jihoon Lee , Ji-Hyeon Jeon , Juyoung Kim , Yeon-Ju Baek , Min-Koo Choi , Soohyun Sung , Jong Won Kim , Sanghyun Lim , Im-Sook Song","doi":"10.1016/j.jff.2025.107046","DOIUrl":"10.1016/j.jff.2025.107046","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107046"},"PeriodicalIF":4.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-31DOI: 10.1016/j.jff.2025.107089
Yan Zheng , Yuqi Si , Xinyi Li , Shuran Jin , Yaling Chen , Xumeng Chen
Sweet-Tasting Plants such as Stevia rebaudiana, Siraitia grosvenorii, and Glycyrrhiza glabra possess dual significance in traditional functional foods, serving both as natural sweeteners and metabolic modulators. This review systematically elaborates on the effects of these plants on glucose uptake, glycolysis, glycogen synthesis and breakdown, gluconeogenesis, and hormonal balance, while providing an in-depth analysis of the molecular mechanisms that underpin their regulation of glucose metabolism. It further summarizes the current applications of these Sweet-Tasting Plants in clinical antidiabetic therapeutics, functional foods, and natural sweeteners, alongside the challenges associated with their use, and proposes directions for future research. These insights establish a robust theoretical foundation for the prevention and control of metabolic diseases, as well as for the innovative development of functional foods, ultimately facilitating the integration of traditional medicine with modern pharmacology.
{"title":"Sweet-Tasting Plants in regulating glucose metabolism: Mechanisms, applications and future directions","authors":"Yan Zheng , Yuqi Si , Xinyi Li , Shuran Jin , Yaling Chen , Xumeng Chen","doi":"10.1016/j.jff.2025.107089","DOIUrl":"10.1016/j.jff.2025.107089","url":null,"abstract":"<div><div>Sweet-Tasting Plants such as <em>Stevia rebaudiana</em>, <em>Siraitia grosvenorii</em>, and <em>Glycyrrhiza glabra</em> possess dual significance in traditional functional foods, serving both as natural sweeteners and metabolic modulators. This review systematically elaborates on the effects of these plants on glucose uptake, glycolysis, glycogen synthesis and breakdown, gluconeogenesis, and hormonal balance, while providing an in-depth analysis of the molecular mechanisms that underpin their regulation of glucose metabolism. It further summarizes the current applications of these Sweet-Tasting Plants in clinical antidiabetic therapeutics, functional foods, and natural sweeteners, alongside the challenges associated with their use, and proposes directions for future research. These insights establish a robust theoretical foundation for the prevention and control of metabolic diseases, as well as for the innovative development of functional foods, ultimately facilitating the integration of traditional medicine with modern pharmacology.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107089"},"PeriodicalIF":4.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-31DOI: 10.1016/j.jff.2025.107084
Geng Zhao , Mingxia Chen , Haojie Zhang , Peizhi Zhu , Wenmin Yang , Qu Liao , Jinhua He , Chuqiao Xiao , Xiang-Guang Li
The common mycotoxin deoxynivalenol (DON) impairs intestinal health, prompting interest in natural, food-based detoxification strategies. This study aimed to identify and evaluate bioactive peptides from rapeseed protein hydrolysate (RPH) capable of alleviating DON-induced enterotoxicity. RPH was extracted from defatted rapeseed meal and demonstrated efficacy against DON-induced enterotoxicity in vivo. Molecular characterization revealed the <1 kDa fraction as predominant (76.09 %), with subsequent peptide sequencing. Bioinformatics and network pharmacology identified FHLY, FYSI, and YYF as promising candidates. Synthesized peptides were evaluated in DON-exposed intestinal epithelial cells. FHLY significantly mitigated enterotoxicity in IPEC-J2 cells by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway. Our findings highlight FHLY as a promising functional food ingredient against mycotoxin toxicity and establish a discovery pipeline for identifying bioactive peptides that exhibit therapeutic effects comparable to interventions targeting DON-induced enterotoxicity. Future research will focus on validating the in vivo efficacy of FHLY and exploring its application in functional foods and feeds.
{"title":"A novel rapeseed-derived peptide FHLY alleviates deoxynivalenol-induced enterotoxicity by inhibiting the TLR4/NF-κB/NLRP3 pathway","authors":"Geng Zhao , Mingxia Chen , Haojie Zhang , Peizhi Zhu , Wenmin Yang , Qu Liao , Jinhua He , Chuqiao Xiao , Xiang-Guang Li","doi":"10.1016/j.jff.2025.107084","DOIUrl":"10.1016/j.jff.2025.107084","url":null,"abstract":"<div><div>The common mycotoxin deoxynivalenol (DON) impairs intestinal health, prompting interest in natural, food-based detoxification strategies. This study aimed to identify and evaluate bioactive peptides from rapeseed protein hydrolysate (RPH) capable of alleviating DON-induced enterotoxicity. RPH was extracted from defatted rapeseed meal and demonstrated efficacy against DON-induced enterotoxicity in vivo. Molecular characterization revealed the <1 kDa fraction as predominant (76.09 %), with subsequent peptide sequencing. Bioinformatics and network pharmacology identified FHLY, FYSI, and YYF as promising candidates. Synthesized peptides were evaluated in DON-exposed intestinal epithelial cells. FHLY significantly mitigated enterotoxicity in IPEC-J2 cells by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway. Our findings highlight FHLY as a promising functional food ingredient against mycotoxin toxicity and establish a discovery pipeline for identifying bioactive peptides that exhibit therapeutic effects comparable to interventions targeting DON-induced enterotoxicity. Future research will focus on validating the in vivo efficacy of FHLY and exploring its application in functional foods and feeds.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107084"},"PeriodicalIF":4.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-31DOI: 10.1016/j.jff.2025.107083
Siqi Wan , Bingcong Xing
This review provides a systematic and up-to-date overview of studies on the chemical composition, pharmacological activities and mechanisms, and applications of lemongrass, aims to establish a scientific and theoretical foundation for the development and utilization of lemongrass resources. Lemongrass primarily contains essential volatile compounds, such as citral and geraniol, as well as flavonoids, polysaccharides, and alkaloids. Due to its diverse composition, lemongrass exhibits a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, immune-modulatory, and insect-repellent properties. These activities have led to its widespread application in sectors such as healthcare, food, chemicals, and animal husbandry. However, because of limited chemical research and technical level, lemongrass is mainly used for extracting essential oils, and the development and utilization of other components and parts of lemongrass are insufficient. Further research on individual components, their biological activities, and the development of functional products will enhance the lemongrass industry and support its sustainable growth.
{"title":"Research progress on chemical composition, biological activity and application of lemongrass and its essential oils","authors":"Siqi Wan , Bingcong Xing","doi":"10.1016/j.jff.2025.107083","DOIUrl":"10.1016/j.jff.2025.107083","url":null,"abstract":"<div><div>This review provides a systematic and up-to-date overview of studies on the chemical composition, pharmacological activities and mechanisms, and applications of lemongrass, aims to establish a scientific and theoretical foundation for the development and utilization of lemongrass resources. Lemongrass primarily contains essential volatile compounds, such as citral and geraniol, as well as flavonoids, polysaccharides, and alkaloids. Due to its diverse composition, lemongrass exhibits a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, immune-modulatory, and insect-repellent properties. These activities have led to its widespread application in sectors such as healthcare, food, chemicals, and animal husbandry. However, because of limited chemical research and technical level, lemongrass is mainly used for extracting essential oils, and the development and utilization of other components and parts of lemongrass are insufficient. Further research on individual components, their biological activities, and the development of functional products will enhance the lemongrass industry and support its sustainable growth.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"135 ","pages":"Article 107083"},"PeriodicalIF":4.0,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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