To assess the effects of algae supplementation on lipid profiles and blood pressure in adults, we conducted a systematic search in PubMed, Scopus, Web of Science, and Cochrane Library for relevant randomized controlled trials (RCTs). A total of 77 RCTs with 3686 participants were included. Algae supplementation significantly reduced triglycerides (TG) (WMD: −7.99 mg/dL, 95 % CI: −12.71, −3.26), total cholesterol (TC) (WMD: −11.01 mg/dL, 95 % CI: −14.26, −7.76), and low-density lipoprotein (LDL) (WMD: −10.17 mg/dL, 95 % CI: −13.12, −7.22) levels, while increasing high-density lipoprotein (HDL) (WMD: 1.66 mg/dL, 95 % CI: 0.73, 2.59). No significant changes were observed in the LDL/HDL ratio and systolic blood pressure (SBP), but diastolic blood pressure (DBP) significantly decreased (WMD: −1.71 mmHg, 95 % CI: −2.72, −0.71). These findings suggest that algae supplementation can improve cardiovascular health markers, although further research is needed to address the observed variability.
{"title":"The effect of algae supplementation on lipid profile and blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials","authors":"Pishva Arzhang , Hana Arghavan , Shervin Kazeminejad , Farzad Mohammadi , Mohammadreza Moradi Baniasadi , Narges Ghorbani Bavani , Hazhir Darvishi , Leila Azadbakht","doi":"10.1016/j.jff.2024.106461","DOIUrl":"10.1016/j.jff.2024.106461","url":null,"abstract":"<div><div>To assess the effects of algae supplementation on lipid profiles and blood pressure in adults, we conducted a systematic search in PubMed, Scopus, Web of Science, and Cochrane Library for relevant randomized controlled trials (RCTs). A total of 77 RCTs with 3686 participants were included. Algae supplementation significantly reduced triglycerides (TG) (WMD: −7.99 mg/dL, 95 % CI: −12.71, −3.26), total cholesterol (TC) (WMD: −11.01 mg/dL, 95 % CI: −14.26, −7.76), and low-density lipoprotein (LDL) (WMD: −10.17 mg/dL, 95 % CI: −13.12, −7.22) levels, while increasing high-density lipoprotein (HDL) (WMD: 1.66 mg/dL, 95 % CI: 0.73, 2.59). No significant changes were observed in the LDL/HDL ratio and systolic blood pressure (SBP), but diastolic blood pressure (DBP) significantly decreased (WMD: −1.71 mmHg, 95 % CI: −2.72, −0.71). These findings suggest that algae supplementation can improve cardiovascular health markers, although further research is needed to address the observed variability.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106461"},"PeriodicalIF":3.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28DOI: 10.1016/j.jff.2024.106470
Qiang Li , Yanbin Zheng , Jianyu Zhao , Xinyi Wei , Zongxin Shi , Haonan Fan , Chenxu Ge , Minxuan Xu , Jun Tan
Diabetic kidney disease (DKD) is a major diabetic complication and a leading cause of end-stage renal disease (ESRD), but the therapeutic strategies for DKD are still limited. Red radishes (Raphanus sativus L.) are a rich source of natural anthocyanins that have antioxidant, anti-apoptotic and anti-inflammatory activities. In this study, we attempted to explore the effects of natural pigment anthocyanin called radish red (RR) extracted from red radishes on DKD progression and the underlying molecular mechanisms. RR dose-dependently reduced the tubular cell injury, indicated by the decreased expression of kidney injury molecule 1 (KIM1). Furthermore, releases of pro-inflammatory cytokines including interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) stimulated by HF were strongly relieved by RR. Inflammatory response and pyroptosis were also identified to be induced by HF stimulation but were mitigated by RR in HK2 cells through repressing nuclear factor-κB (NF-κB) activation and NLR family, pyrin domain-containing 3 (NLRP3) inflammasome. IR and lipogenesis due to HF exposure were also significantly ameliorated by RR in HK2 cells. Mechanistically, RNA-Seq analysis showed that RR strongly depressed interleukin-1 receptor-associated kinase-1 (IRAK1)-mediated NLRP3 inflammasome, pyroptosis, IR and lipid deposition. Importantly, IRAK1 overexpression almost diminished the beneficial effects of RR, while being rescued upon NLRP3 knockdown in HF-treated HK2 cells, revealing that RR performed its nephroprotective functions in diabetic kidney via inactivating the IRAK1-NLRP3 signaling pathway. Similarly, animal studies confirmed that RR supplementation efficiently ameliorated HFF-caused metabolic disturbance, IR, renal dysfunctions in mice and improved structural kidney damage. Consistently, RR consumption dramatically reduced lipid accumulation, inflammatory response and pyroptosis in kidney tissues of HFF-challenged mice mainly through repressing IRAK1-NLRP3 axis. Our results demonstrated that dietary supplementation with RR may serve as an IRAK1-NLRP3 inhibitor for preventing and treating diabetic nephropathy.
{"title":"Radish red protects against early diabetic kidney disease through inhibiting inflammation, pyroptosis and insulin resistance via IRAK1 signaling suppression","authors":"Qiang Li , Yanbin Zheng , Jianyu Zhao , Xinyi Wei , Zongxin Shi , Haonan Fan , Chenxu Ge , Minxuan Xu , Jun Tan","doi":"10.1016/j.jff.2024.106470","DOIUrl":"10.1016/j.jff.2024.106470","url":null,"abstract":"<div><div>Diabetic kidney disease (DKD) is a major diabetic complication and a leading cause of end-stage renal disease (ESRD), but the therapeutic strategies for DKD are still limited. Red radishes (<em>Raphanus sativus</em> L.) are a rich source of natural anthocyanins that have antioxidant, anti-apoptotic and anti-inflammatory activities. In this study, we attempted to explore the effects of natural pigment anthocyanin called radish red (RR) extracted from red radishes on DKD progression and the underlying molecular mechanisms. RR dose-dependently reduced the tubular cell injury, indicated by the decreased expression of kidney injury molecule 1 (KIM1). Furthermore, releases of pro-inflammatory cytokines including interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) stimulated by HF were strongly relieved by RR. Inflammatory response and pyroptosis were also identified to be induced by HF stimulation but were mitigated by RR in HK2 cells through repressing nuclear factor-κB (NF-κB) activation and NLR family, pyrin domain-containing 3 (NLRP3) inflammasome. IR and lipogenesis due to HF exposure were also significantly ameliorated by RR in HK2 cells. Mechanistically, RNA-Seq analysis showed that RR strongly depressed interleukin-1 receptor-associated kinase-1 (IRAK1)-mediated NLRP3 inflammasome, pyroptosis, IR and lipid deposition. Importantly, IRAK1 overexpression almost diminished the beneficial effects of RR, while being rescued upon NLRP3 knockdown in HF-treated HK2 cells, revealing that RR performed its nephroprotective functions in diabetic kidney via inactivating the IRAK1-NLRP3 signaling pathway. Similarly, animal studies confirmed that RR supplementation efficiently ameliorated HFF-caused metabolic disturbance, IR, renal dysfunctions in mice and improved structural kidney damage. Consistently, RR consumption dramatically reduced lipid accumulation, inflammatory response and pyroptosis in kidney tissues of HFF-challenged mice mainly through repressing IRAK1-NLRP3 axis. Our results demonstrated that dietary supplementation with RR may serve as an IRAK1-NLRP3 inhibitor for preventing and treating diabetic nephropathy.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106470"},"PeriodicalIF":3.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28DOI: 10.1016/j.jff.2024.106465
Yexing Tao , Huifang Niu , Qian Yu , Lin Xiang , Xiwen Zhang , Ting Wu , Siyi Pan , Xiaoyun Xu
Pericarpium Citri Reticulatae ‘Chachi’ (PCR-C), abundant in flavonoids, is traditionally believed to enhance its pharmacological effects with long-term storage. The efficacy of these flavonoids is closely related to their intestinal absorption, which is primarily affected by P-glycoprotein (P-gp). This study explored the interaction between flavonoid absorption and P-gp in PCR-C flavonoid extracts (PCR-CF) over different storage periods using a Caco-2 monolayer model and KB/MDR cells, respectively. The transported concentrations (TC) of key flavonoids-hesperidin, isosinensetin, nobiletin, and tangeretin-significantly varied with the storage duration of PCR-CF. Notably, nobiletin and tangeretin enhanced the TC of these flavonoids by inhibiting P-gp activity, thereby influencing intestinal absorption of PCR-CF with different storage time. These findings provide a scientific basis for the traditional belief that long-stored PCR-C possesses superior medicinal properties.
{"title":"Effect of storage periods on flavonoid absorption and P-glycoprotein interaction in Pericarpium Citri Reticulatae ‘Chachi’ flavonoid extracts","authors":"Yexing Tao , Huifang Niu , Qian Yu , Lin Xiang , Xiwen Zhang , Ting Wu , Siyi Pan , Xiaoyun Xu","doi":"10.1016/j.jff.2024.106465","DOIUrl":"10.1016/j.jff.2024.106465","url":null,"abstract":"<div><div><em>Pericarpium Citri Reticulatae ‘Chachi’</em> (PCR-C), abundant in flavonoids, is traditionally believed to enhance its pharmacological effects with long-term storage. The efficacy of these flavonoids is closely related to their intestinal absorption, which is primarily affected by P-glycoprotein (P-gp). This study explored the interaction between flavonoid absorption and P-gp in PCR-C flavonoid extracts (PCR-CF) over different storage periods using a Caco-2 monolayer model and KB/MDR cells, respectively. The transported concentrations (TC) of key flavonoids-hesperidin, isosinensetin, nobiletin, and tangeretin-significantly varied with the storage duration of PCR-CF. Notably, nobiletin and tangeretin enhanced the TC of these flavonoids by inhibiting P-gp activity, thereby influencing intestinal absorption of PCR-CF with different storage time. These findings provide a scientific basis for the traditional belief that long-stored PCR-C possesses superior medicinal properties.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106465"},"PeriodicalIF":3.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28DOI: 10.1016/j.jff.2024.106459
Xu-Qiang Liu , Wen-Jing Shao , Xiao-Peng Liu , Yu Zhang , Hui Liu , Jin-Mei Wang , Changyang Ma
This study explored the active ingredients and mechanism of Pleurotus placentodes extract (PP-a) in alleviating acute liver injury. According to un-targeted metabolomics analysis, 102 compounds were identified in PP-a, 32 were regarded as active compounds for treating liver injury. PP-a’s targets (2 0 3) were observed for liver injury by network pharmacology analysis. Animal tests showed that PP-a significantly reduce inflammatory factors, increase anti-oxidative effects, and repair injured liver tissues, further effectively improving liver function. In addition, the mRNA expression of PTGS2 and NR3C1 was significantly reduced, while the mRNA expression of PPARA was significantly increased in CCl4-induced mice as a result of PP-a. These results suggest that P. placentodes exerts hepatoprotective effects probably by regulating the mRNA expression of PTGS2, NR3C1 and PPARA. For PP-a, L-Histidine, N-Acetyl-D-alloisoleucine, 15-OxoEDE and palmitic acid probably play a critical role in protecting against liver injury in CCl4-indcued mice.
{"title":"Protective effects of Pleurotus placentodes against liver injury in mice via the PTGS2, NR3C1 and PPARA signaling pathways","authors":"Xu-Qiang Liu , Wen-Jing Shao , Xiao-Peng Liu , Yu Zhang , Hui Liu , Jin-Mei Wang , Changyang Ma","doi":"10.1016/j.jff.2024.106459","DOIUrl":"10.1016/j.jff.2024.106459","url":null,"abstract":"<div><div>This study explored the active ingredients and mechanism of <em>Pleurotus placentodes</em> extract (PP-a) in alleviating acute liver injury. According to un-targeted metabolomics analysis, 102 compounds were identified in PP-a, 32 were regarded as active compounds for treating liver injury. PP-a’s targets (2<!--> <!-->0<!--> <!-->3) were observed for liver injury by network pharmacology analysis. Animal tests showed that PP-a significantly reduce inflammatory factors, increase anti-oxidative effects, and repair injured liver tissues, further effectively improving liver function. In addition, the mRNA expression of <em>PTGS2</em> and <em>NR3C1</em> was significantly reduced, while the mRNA expression of <em>PPARA</em> was significantly increased in CCl<sub>4</sub>-induced mice as a result of PP-a. These results suggest that <em>P. placentodes</em> exerts hepatoprotective effects probably by regulating the mRNA expression of <em>PTGS2</em>, <em>NR3C1</em> and <em>PPARA</em>. For PP-a, L-Histidine, N-Acetyl-D-alloisoleucine, 15-OxoEDE and palmitic acid probably play a critical role in protecting against liver injury in CCl<sub>4</sub>-indcued mice.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106459"},"PeriodicalIF":3.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-27DOI: 10.1016/j.jff.2024.106484
Yu Han , Yan Liu , Ruirui Guo , Yuqi Gao , Yuangang Guo , Jing Zhao , Sitong Xin , Yang Xu , Bo Li , Xiumin Liu
Background
Non-alcoholic fatty liver disease (NAFLD) is a classic disease of liver injury, and studies have confirmed that nutrients can influence NAFLD. Findings on serum vitamin D (VD) and NAFLD are conflicting and the mechanisms are not yet clear. This study aimed to determine the association between the two and the mediating role mediated by body mass index (BMI).
Methods
A cross-sectional study (N = 2609) was conducted using the 2017–2018 National Health and Nutrition Examination Survey (NHANES) dataset. Weighted multivariate logistic regression models estimated OR and 95 % CIs between serum VD and NAFLD. The mediation analysis was performed for BMI.
Results
Serum VD was statistically significant in subjects with and without NAFLD (P = 0.026). Adequate serum VD was found to be a protective factor for NAFLD after adjusting for covariates (OR (95 %CI) of 0.717 (0.553,0.929)). After mediation analysis, it was found that BMI mediated 34.07 % of the effect of serum VD on NAFLD.
Conclusion
There is an association between serum vitamin D and NAFLD and sufficient VD was protective factor for NAFLD. BMI partly mediated the association between serum VD and NAFLD.
背景非酒精性脂肪肝（NAFLD）是一种典型的肝损伤疾病，研究证实营养素可影响非酒精性脂肪肝。有关血清维生素 D（VD）与非酒精性脂肪肝的研究结果相互矛盾，其机制也尚不清楚。本研究旨在确定两者之间的关联以及体重指数（BMI）所起的中介作用。方法利用2017-2018年美国国家健康与营养调查（NHANES）数据集进行了一项横断面研究（N = 2609）。加权多变量逻辑回归模型估算了血清 VD 与非酒精性脂肪肝之间的 OR 和 95 % CI。结果非酒精性脂肪肝患者和非酒精性脂肪肝患者的血清 VD 均有统计学意义（P = 0.026）。调整协变量后发现，充足的血清 VD 是非酒精性脂肪肝的保护因素（OR (95 %CI) 为 0.717 (0.553,0.929) ）。结论血清维生素 D 与非酒精性脂肪肝之间存在关联，充足的维生素 D 是非酒精性脂肪肝的保护因素。体重指数在一定程度上介导了血清维生素D与非酒精性脂肪肝之间的关系。
{"title":"The role of body mass index in the association between serum vitamin D and non-alcoholic fatty liver disease: A mediation analysis","authors":"Yu Han , Yan Liu , Ruirui Guo , Yuqi Gao , Yuangang Guo , Jing Zhao , Sitong Xin , Yang Xu , Bo Li , Xiumin Liu","doi":"10.1016/j.jff.2024.106484","DOIUrl":"10.1016/j.jff.2024.106484","url":null,"abstract":"<div><h3>Background</h3><div>Non-alcoholic fatty liver disease (NAFLD) is a classic disease of liver injury, and studies have confirmed that nutrients can influence NAFLD. Findings on serum vitamin D (VD) and NAFLD are conflicting and the mechanisms are not yet clear. This study aimed to determine the association between the two and the mediating role mediated by body mass index (BMI).</div></div><div><h3>Methods</h3><div>A cross-sectional study (N = 2609) was conducted using the 2017–2018 National Health and Nutrition Examination Survey (NHANES) dataset. Weighted multivariate logistic regression models estimated OR and 95 % CIs between serum VD and NAFLD. The mediation analysis was performed for BMI.</div></div><div><h3>Results</h3><div>Serum VD was statistically significant in subjects with and without NAFLD (<em>P</em> = 0.026). Adequate serum VD was found to be a protective factor for NAFLD after adjusting for covariates (OR (95 %CI) of 0.717 (0.553,0.929)). After mediation analysis, it was found that BMI mediated 34.07 % of the effect of serum VD on NAFLD.</div></div><div><h3>Conclusion</h3><div>There is an association between serum vitamin D and NAFLD and sufficient VD was protective factor for NAFLD. BMI partly mediated the association between serum VD and NAFLD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106484"},"PeriodicalIF":3.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-27DOI: 10.1016/j.jff.2024.106483
Jinrong Zhao , Yuehong Ji , Guifang Tian, Yixin Zheng, Yaxin Sang, Jie Gao
This study was amied to explore the molecular mechanisms of the effect of pear pomace soluble dietary fiber (PP-SDF) on weight gain, fat deposition and regulation of lipid metabolism in obese mice. The PP-SDF can positively modulate the adverse effects of obesity. In this study, the PP-SDF extracted via microbial fermentation was investigated for its weight loss mechanism in high-fat diet induced obese mice. Soluble dietary fiber was also investigated for the enzymes related to fat metabolism and for intervention to reduce adipose inflammation related to obesity. Furthermore, AMPK and PPAR-α signaling pathway related to ADPN were investigated and the key enzymes in the pathways were measured. The results show that PP-SDF regulated obesity-related metabolic disorders by inhibiting obesity inflammation and by activating AMPK/PPAR-α signaling pathway, while ADPN was the key target for the regulation of these two pathways.
{"title":"Pear pomace soluble dietary fiber suppresses fat deposition in high fat diet-fed mice by regulating the ADPN-AMPK/PPAR-α signaling pathway","authors":"Jinrong Zhao , Yuehong Ji , Guifang Tian, Yixin Zheng, Yaxin Sang, Jie Gao","doi":"10.1016/j.jff.2024.106483","DOIUrl":"10.1016/j.jff.2024.106483","url":null,"abstract":"<div><div>This study was amied to explore the molecular mechanisms of the effect of pear pomace soluble dietary fiber (PP-SDF) on weight gain, fat deposition and regulation of lipid metabolism in obese mice. The PP-SDF can positively modulate the adverse effects of obesity. In this study, the PP-SDF extracted via microbial fermentation was investigated for its weight loss mechanism in high-fat diet induced obese mice. Soluble dietary fiber was also investigated for the enzymes related to fat metabolism and for intervention to reduce adipose inflammation related to obesity. Furthermore, AMPK and PPAR-α signaling pathway related to ADPN were investigated and the key enzymes in the pathways were measured. The results show that PP-SDF regulated obesity-related metabolic disorders by inhibiting obesity inflammation and by activating AMPK/PPAR-α signaling pathway, while ADPN was the key target for the regulation of these two pathways.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106483"},"PeriodicalIF":3.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-24DOI: 10.1016/j.jff.2024.106460
Haiqiu Huang , Quynhchi Pham , Liangli Yu , Stephen M. Boue , Thomas T.Y. Wang
Glyceollins are soy-derived phytoalexins that have been proposed as candidate compounds for the prevention of prostate cancer. The present study tested the efficacies of glyceollins on prostate cancer prevention in-vitro and in-vivo. In-vitro, glyceollins significantly inhibited the androgen-responsive LNCaP cell growth consistent with inhibition of the androgen-mediated pathway. In-vivo, dietary glyceollins attenuated LNCaP tumor xenograft growth in a nude mouse model and correlated with the inhibition of tumor cells proliferative marker PCNA mRNA levels. However, unlike in-vitro, dietary glyceollins did not affect marker genes for the androgen- responsive pathway, cell cycle, and angiogenesis in the tumor xenograft. Dietary glyceollins also did not affect the marker genes for xenobiotic metabolism, cholesterol transport, or inflammatory pathways in liver. The low bioavailability of glyceollins (0.054 ± 0.013 µM in the plasma) might have led to the lack of effectiveness of glyceollins on the marker genes in-vivo. Interestingly, dietary glyceollins significantly lower the abundance of cecal Bifidobacterium, butyrate producing bacteria, compared to the control diet. Thus, glyceollins act differently in-vitro and in-vivo. The protective effects of glyceollins in-vivo may be independent of the androgen responsive pathway but related to modulation of the butyrate, a putative prostate cancer promoting agent, production by the gut microbiome.
{"title":"Differential preventative effect of soy-derived phytochemical glyceollins on prostate cancer in-vitro and in mouse tumor xenograft is related to bioavailability of glyceollins and modulation of the gut microbiome","authors":"Haiqiu Huang , Quynhchi Pham , Liangli Yu , Stephen M. Boue , Thomas T.Y. Wang","doi":"10.1016/j.jff.2024.106460","DOIUrl":"10.1016/j.jff.2024.106460","url":null,"abstract":"<div><div>Glyceollins are soy-derived phytoalexins that have been proposed as candidate compounds for the prevention of prostate cancer. The present study tested the efficacies of glyceollins on prostate cancer prevention in-vitro and in-vivo. In-vitro, glyceollins significantly inhibited the androgen-responsive LNCaP cell growth consistent with inhibition of the androgen-mediated pathway. In-vivo, dietary glyceollins attenuated LNCaP tumor xenograft growth in a nude mouse model and correlated with the inhibition of tumor cells proliferative marker PCNA mRNA levels. However, unlike in-vitro, dietary glyceollins did not affect marker genes for the androgen- responsive pathway, cell cycle, and angiogenesis in the tumor xenograft. Dietary glyceollins also did not affect the marker genes for xenobiotic metabolism, cholesterol transport, or inflammatory pathways in liver. The low bioavailability of glyceollins (0.054 ± 0.013 µM in the plasma) might have led to the lack of effectiveness of glyceollins on the marker genes <em>in-vivo</em>. Interestingly, dietary glyceollins significantly lower the abundance of cecal <em>Bifidobacterium</em>, butyrate producing bacteria, compared to the control diet. Thus, glyceollins act differently <em>in-vitro</em> and <em>in-vivo</em>. The protective effects of glyceollins in-vivo may be independent of the androgen responsive pathway but related to modulation of the butyrate, a putative prostate cancer promoting agent, production by the gut microbiome.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106460"},"PeriodicalIF":3.8,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756464624004626/pdfft?md5=209ce6ff3ad3679b4bb71ec5ef46d474&pid=1-s2.0-S1756464624004626-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-23DOI: 10.1016/j.jff.2024.106463
Yujia Liu , Qing Li , Luo Fang , Xiaoping Hu , Zongfu Pan , Qing Hu , Mengting Cheng , Xinyu Tao , Yiwen Zhang , Ping Huang
Colorectal cancer is one of the most common cancers and the main causes of mortality around the world and Oxaliplatin is a first-line chemotherapy agent for treatment of CRC. However, the dense collagen network in tumors stroma significantly reduces the penetration and efficacy of Oxaliplatin. Therefore, research strategies to further sensitize CRC cells to Oxaliplatin are urgently needed. In this study, we showed that Semen Raphani exhibited a strong synergy with Oxaliplatin to inhibit CRC tumor growth by remodeling tumor stroma and depredate collagen. Further research found that ATG9A mediated autophagy is critical for the collagen degradation induced by Semen Raphani, this process may be mediated by the degradation of collagen transcription factor STAT3 by autophagy. Taken together, our study is the first to evaluate the synergy of Semen Raphani and Oxaliplatin in CRC and to assess new opportunities for remodeling stroma as a promising approach for future chemotherapy sensitization.
{"title":"Semen Raphani Remodels tumor-stroma and Enhances the antitumor effect of Oxaliplatin via ATG9A mediated autophagy in colorectal cancer","authors":"Yujia Liu , Qing Li , Luo Fang , Xiaoping Hu , Zongfu Pan , Qing Hu , Mengting Cheng , Xinyu Tao , Yiwen Zhang , Ping Huang","doi":"10.1016/j.jff.2024.106463","DOIUrl":"10.1016/j.jff.2024.106463","url":null,"abstract":"<div><div>Colorectal cancer is one of the most common cancers and the main causes of mortality around the world and Oxaliplatin is a first-line chemotherapy agent for treatment of CRC. However, the dense collagen network in tumors stroma significantly reduces the penetration and efficacy of Oxaliplatin. Therefore, research strategies to further sensitize CRC cells to Oxaliplatin are urgently needed. In this study, we showed that <em>Semen Raphani</em> exhibited a strong synergy with Oxaliplatin to inhibit CRC tumor growth by remodeling tumor stroma and depredate collagen. Further research found that ATG9A mediated autophagy is critical for the collagen degradation induced by <em>Semen Raphani</em>, this process may be mediated by the degradation of collagen transcription factor STAT3 by autophagy. Taken together, our study is the first to evaluate the synergy of <em>Semen Raphani</em> and Oxaliplatin in CRC and to assess new opportunities for remodeling stroma as a promising approach for future chemotherapy sensitization.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106463"},"PeriodicalIF":3.8,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756464624004651/pdfft?md5=1b32f67f223abf4e96deea3380ca4857&pid=1-s2.0-S1756464624004651-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-22DOI: 10.1016/j.jff.2024.106469
Xun Gou , Jiang Chen , Xinxing Ran , Linling Deng , Yuan Deng , Chaojie Liu , Shiyuan Long , Jie Xie , Tong Peng , Xiaoyu Zhang
Here, the effects of konjac glucomannan (KGM) and oligo-glucomannan (KOGM) on improving Aβ-induced Alzheimer’s disease (AD) was investigated. Behavioral test suggested that both KGM and KOGM could significantly increase the spatial learning and memory of AD mice, with the latter be more effective. Biochemical examinations revealed that KOGM inhibited the Aβ accumulation and hyperphosphorylation of Tau protein, upregulated bdnf, trkb, pi3k and akt, and downregulated gsk3β. Metagenomic sequencing indicated that KOGM regulated the diversity and function of microbiota, especially bacteria belonging to Alistipes, thus promoting the production of short chain fatty acids (SCFAs), as well as their cyclic levels. The strong relationships among gut microbiota, SCFAs and physiological index for AD suggested that KOGM could activated BDNF/PI3K/GSK3β pathway to ameliorate AD, by enhancing SCFAs levels. This study emphasized the KOGM as a potential prebiotic to prevent AD progression, through the gut-brain axis and constitutes a novel approach in AD treatment.
{"title":"Konjac oligo-glucomannan ameliorate cognition impairments of Aβ1-42 induced Alzheimer’s disease in mice by targeting microbiota-SCFAs-brain axis","authors":"Xun Gou , Jiang Chen , Xinxing Ran , Linling Deng , Yuan Deng , Chaojie Liu , Shiyuan Long , Jie Xie , Tong Peng , Xiaoyu Zhang","doi":"10.1016/j.jff.2024.106469","DOIUrl":"10.1016/j.jff.2024.106469","url":null,"abstract":"<div><div>Here, the effects of konjac glucomannan (KGM) and oligo-glucomannan (KOGM) on improving Aβ-induced Alzheimer’s disease (AD) was investigated. Behavioral test suggested that both KGM and KOGM could significantly increase the spatial learning and memory of AD mice, with the latter be more effective. Biochemical examinations revealed that KOGM inhibited the Aβ accumulation and hyperphosphorylation of Tau protein, upregulated <em>bdnf</em>, <em>trkb</em>, <em>pi3k</em> and <em>akt</em>, and downregulated <em>gsk3β</em>. Metagenomic sequencing indicated that KOGM regulated the diversity and function of microbiota, especially bacteria belonging to <em>Alistipes</em>, thus promoting the production of short chain fatty acids (SCFAs), as well as their cyclic levels. The strong relationships among gut microbiota, SCFAs and physiological index for AD suggested that KOGM could activated BDNF/PI3K/GSK3β pathway to ameliorate AD, by enhancing SCFAs levels. This study emphasized the KOGM as a potential prebiotic to prevent AD progression, through the gut-brain axis and constitutes a novel approach in AD treatment.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106469"},"PeriodicalIF":3.8,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756464624004717/pdfft?md5=066f53171d37015f5d3eafed730d8220&pid=1-s2.0-S1756464624004717-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-21DOI: 10.1016/j.jff.2024.106473
Shan-Chi Liu , Tung-Ying Wu , Trung-Loc Ho , Chun-Hao Tsai , Wen-Hui Chung , Yen-You Lin , Yang-Chang Wu , Chih-Hsin Tang
Rheumatoid arthritis (RA) is a well-known autoimmune disorder associated with joint pain, swelling, cartilage and bone degradation, as well as deformity. In cellular and animal model investigations, extracts from Antrodia cinnamomea, a traditional medicinal fungus used in Taiwan, demonstrate anti-inflammatory properties. The 25(S) ergostane stereo-isomer of antcin K, known as 25S-antcin K, was previously isolated from A. cinnamomea and was found to exhibit a more potent effect than antcin K. In the current study, we examined the anti-RA effects of 25S-antcin K. 25S-antcin K abolishes IL-1β-induced promotion of TNF-α, CCL2, and VEGF arthritic factors production by inhibiting AMPK, Akt, and p38 pathways and enhancing miR-374b expression. Importantly, administration of 25S-antcin K also antagonizes collagen-induced arthritis-induced RA symptoms, such as inflammation, cartilage degradation, and bone erosion in vivo. These results provide a novel avenue, suggesting that 25S-antcin K is a potential candidate for developing RA therapy agents.
类风湿性关节炎（RA）是一种众所周知的自身免疫性疾病，与关节疼痛、肿胀、软骨和骨骼退化以及畸形有关。在细胞和动物模型研究中，台湾的一种传统药用真菌--肉桂蕨的提取物显示出抗炎特性。在本研究中，我们考察了 25S-antcin K 的抗 RA 作用。25S-antcin K通过抑制AMPK、Akt和p38通路以及增强miR-374b的表达，抑制了IL-1β诱导的促进TNF-α、CCL2和VEGF关节炎因子的产生。重要的是，服用 25S-antcin K 还能拮抗胶原蛋白诱导的关节炎引起的 RA 症状，如体内炎症、软骨退化和骨侵蚀。这些结果提供了一个新的途径，表明 25S-antcin K 是开发 RA 治疗药物的潜在候选者。
{"title":"Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis","authors":"Shan-Chi Liu , Tung-Ying Wu , Trung-Loc Ho , Chun-Hao Tsai , Wen-Hui Chung , Yen-You Lin , Yang-Chang Wu , Chih-Hsin Tang","doi":"10.1016/j.jff.2024.106473","DOIUrl":"10.1016/j.jff.2024.106473","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is a well-known autoimmune disorder associated with joint pain, swelling, cartilage and bone degradation, as well as deformity. In cellular and animal model investigations, extracts from <em>Antrodia cinnamomea</em>, a traditional medicinal fungus used in Taiwan, demonstrate anti-inflammatory properties. The 25(<em>S</em>) ergostane stereo-isomer of antcin K, known as 25<em>S</em>-antcin K, was previously isolated from <em>A. cinnamomea</em> and was found to exhibit a more potent effect than antcin K. In the current study, we examined the anti-RA effects of 25<em>S</em>-antcin K. 25<em>S</em>-antcin K abolishes IL-1β-induced promotion of TNF-α, CCL2, and VEGF arthritic factors production by inhibiting AMPK, Akt, and p38 pathways and enhancing miR-374b expression. Importantly, administration of 25<em>S</em>-antcin K also antagonizes collagen-induced arthritis-induced RA symptoms, such as inflammation, cartilage degradation, and bone erosion <em>in vivo</em>. These results provide a novel avenue, suggesting that 25<em>S</em>-antcin K is a potential candidate for developing RA therapy agents.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106473"},"PeriodicalIF":3.8,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756464624004754/pdfft?md5=de4822eb3a98c70689af0e4ef57fddff&pid=1-s2.0-S1756464624004754-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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