Pub Date : 2025-10-21DOI: 10.1016/j.jff.2025.107072
Yuchen Huang , Can Zhang , Hongkun Xue , Jiaqi Tan
With the change of modern lifestyle, low immunity has become a health problem faced by more and more people. Hence, the development of natural active products with immunomodulatory activity has become one of the current hot research issues. Polysaccharides have attracted much attention in immunomodulatory activity due to their rich sources, good safety, few side effects, and stable therapeutic effects. Currently, existing research on immunoactive polysaccharides still has deficiencies and fails to fully clarify their multi-level regulatory mechanisms and structure-activity relationships. Therefore, this article systematically reviews the relationship between polysaccharide structure (molecular weight, monosaccharide composition, glycosidic bonds, substituent, and high structure) and immunomodulatory activity. Moreover, this review systematically summarizes the immunoregulation action mechanisms of polysaccharides from three aspects including immune system regulation, immunomodulatory receptors, and the regulation of intestinal flora. Furthermore, the challenges of current studies on the immunomodulatory activity of polysaccharides and future research directions were discussed. The results can enhance the understanding of polysaccharides with immunomodulatory activity from different resources, which provides theoretical support for the development and application of polysaccharides as dietary supplements and their precision nutrition strategies.
{"title":"Research progress on the structure-activity relationship and action mechanisms of polysaccharides with immunomodulatory activity","authors":"Yuchen Huang , Can Zhang , Hongkun Xue , Jiaqi Tan","doi":"10.1016/j.jff.2025.107072","DOIUrl":"10.1016/j.jff.2025.107072","url":null,"abstract":"<div><div>With the change of modern lifestyle, low immunity has become a health problem faced by more and more people. Hence, the development of natural active products with immunomodulatory activity has become one of the current hot research issues. Polysaccharides have attracted much attention in immunomodulatory activity due to their rich sources, good safety, few side effects, and stable therapeutic effects. Currently, existing research on immunoactive polysaccharides still has deficiencies and fails to fully clarify their multi-level regulatory mechanisms and structure-activity relationships. Therefore, this article systematically reviews the relationship between polysaccharide structure (molecular weight, monosaccharide composition, glycosidic bonds, substituent, and high structure) and immunomodulatory activity. Moreover, this review systematically summarizes the immunoregulation action mechanisms of polysaccharides from three aspects including immune system regulation, immunomodulatory receptors, and the regulation of intestinal flora. Furthermore, the challenges of current studies on the immunomodulatory activity of polysaccharides and future research directions were discussed. The results can enhance the understanding of polysaccharides with immunomodulatory activity from different resources, which provides theoretical support for the development and application of polysaccharides as dietary supplements and their precision nutrition strategies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107072"},"PeriodicalIF":4.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145359104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-21DOI: 10.1016/j.jff.2025.107069
Yi Li , Xingyu Xiao , Tong Su , Qinchuan Lv , Jiayuan Fang , Shuo Zheng , Xunming Zhang , Dongyue Liu , Linlin Hao , Huayi Lu
Alcoholic liver disease (ALD) is a prevalent liver disorder caused by excessive alcohol consumption, and oxidative stress plays a key role in its pathogenesis. Antioxidant peptides are promising candidates for ALD therapy, and in this study, we investigated the protective effects of deer blood peptides (DBP) against ALD. We established an efficient method of extracting DBP through single-factor optimization and response surface methodology, identifying papain as the most effective protease and determining optimal hydrolysis conditions. DBP consists primarily of peptides with molecular weights <3 kDa, which exhibit strong scavenging capacity against multiple free radicals and excellent biocompatibility. In H2O2-induced HepG2 cells, DBP pretreatment increased the cell survival rate, increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced malondialdehyde (MDA) levels. In an alcohol-induced liver injury mouse model, DBP reduced the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). It improved the hepatic antioxidant status and alleviated fatty liver lesions. Through peptidomics and bioinformatics analysis, 13 potential antioxidant peptides were identified. Molecular docking revealed that these peptides spontaneously bind to 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). We synthesized QGPLEPGPAGNRGCGRK (QK17) and PPSPGAMPRPP (PP11), both of which have excellent radical scavenging activity and cellular protective effects. Moreover, molecular docking revealed that PP11 binds to Keap1 (−10.2 kcal/mol), potentially regulating the Keap1-Nrf2 pathway. These findings indicate that DBP may serve as a promising therapeutic agent for ALD, assisting in its prevention while promoting the utilization of deer blood resources.
{"title":"Isolation, identification, and computational analysis of antioxidant peptides from deer blood and its therapeutic effects on alcoholic liver injury in mice","authors":"Yi Li , Xingyu Xiao , Tong Su , Qinchuan Lv , Jiayuan Fang , Shuo Zheng , Xunming Zhang , Dongyue Liu , Linlin Hao , Huayi Lu","doi":"10.1016/j.jff.2025.107069","DOIUrl":"10.1016/j.jff.2025.107069","url":null,"abstract":"<div><div>Alcoholic liver disease (ALD) is a prevalent liver disorder caused by excessive alcohol consumption, and oxidative stress plays a key role in its pathogenesis. Antioxidant peptides are promising candidates for ALD therapy, and in this study, we investigated the protective effects of deer blood peptides (DBP) against ALD. We established an efficient method of extracting DBP through single-factor optimization and response surface methodology, identifying papain as the most effective protease and determining optimal hydrolysis conditions. DBP consists primarily of peptides with molecular weights <3 kDa, which exhibit strong scavenging capacity against multiple free radicals and excellent biocompatibility. In H2O2-induced HepG2 cells, DBP pretreatment increased the cell survival rate, increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), and reduced malondialdehyde (MDA) levels. In an alcohol-induced liver injury mouse model, DBP reduced the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). It improved the hepatic antioxidant status and alleviated fatty liver lesions. Through peptidomics and bioinformatics analysis, 13 potential antioxidant peptides were identified. Molecular docking revealed that these peptides spontaneously bind to 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). We synthesized QGPLEPGPAGNRGCGRK (QK17) and PPSPGAMPRPP (PP11), both of which have excellent radical scavenging activity and cellular protective effects. Moreover, molecular docking revealed that PP11 binds to Keap1 (−10.2 kcal/mol), potentially regulating the Keap1-Nrf2 pathway. These findings indicate that DBP may serve as a promising therapeutic agent for ALD, assisting in its prevention while promoting the utilization of deer blood resources.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107069"},"PeriodicalIF":4.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145359106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-21DOI: 10.1016/j.jff.2025.107070
Jianwei Yu , Shu Xing , Rui Sun , Ling Wang , Xiaodeng Yang , Mingyong Zeng
Aging is a universal biological process involving cellular and molecular changes that lead to various age-related issues. Skin aging, both natural and exogenous factors, is a prominent manifestation of this process. Oligopeptides, particularly those derived from marine sources such as jellyfish collagen polypeptides, have demonstrated significantly potential in anti-aging applications due to their diverse biological activities. This study systematically investigated the anti-aging effects of jellyfish collagen peptides on skin using multiple methods, including cytotoxicity assessment, in vitro cell experiments, and evaluations of free radical scavenging, anti-wrinkle effects, collagen proliferation, cytokine inhibition, and protection against cellular damage. The findings indicate that jellyfish collagen peptides can delay skin aging through multiple mechanisms, providing valuable insights for the development of anti-aging skincare products.
{"title":"Jellyfish collagen peptides: anti-aging mechanism and potential application in skincare","authors":"Jianwei Yu , Shu Xing , Rui Sun , Ling Wang , Xiaodeng Yang , Mingyong Zeng","doi":"10.1016/j.jff.2025.107070","DOIUrl":"10.1016/j.jff.2025.107070","url":null,"abstract":"<div><div>Aging is a universal biological process involving cellular and molecular changes that lead to various age-related issues. Skin aging, both natural and exogenous factors, is a prominent manifestation of this process. Oligopeptides, particularly those derived from marine sources such as jellyfish collagen polypeptides, have demonstrated significantly potential in anti-aging applications due to their diverse biological activities. This study systematically investigated the anti-aging effects of jellyfish collagen peptides on skin using multiple methods, including cytotoxicity assessment, in vitro cell experiments, and evaluations of free radical scavenging, anti-wrinkle effects, collagen proliferation, cytokine inhibition, and protection against cellular damage. The findings indicate that jellyfish collagen peptides can delay skin aging through multiple mechanisms, providing valuable insights for the development of anti-aging skincare products.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107070"},"PeriodicalIF":4.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145359105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-17DOI: 10.1016/j.jff.2025.107067
Shaolin Huang , Chuan Wu , Can Di , Zhongxia Li , Wenxi Wang , Xiaomeng Wang , Haonan Wang , Fan Huang , Wen Du , Wenya Yin
The present study demonstrates that postbiotic Bifidobacterium. breve 207–1 (250, 500, 1000 μg/mL) ameliorates high glucose diet-induced glycolipid metabolic disorders in Caenorhabditis elegans by converging glucose metabolism, lipid homeostasis, and oxidative stress resolution onto the conserved daf-2/daf-16 signaling axis. The postbiotic demonstrated a substantial reduction in glucose, glycogen, and triglycerides, while concurrently suppressing ROS/lipofuscin accumulation and extending lifespan. Mechanistically, by inhibiting the insulin receptor daf-2 and subsequent activation of the transcription factor daf-16, the postbiotic enhanced glycolytic flux (hxk-2, gpd-2, pyk-2) while concurrently suppressing glycogenesis (gsy-1, pygl-1), promoted β-oxidation (acs-2, cpt-4) yet inhibited lipogenesis (mdt-15/sbp-1, fat-7), and induced antioxidant defense (sod-3), ultimately disrupting the vicious cycle between metabolic dysfunction and oxidative damage. These findings position B. breve 207–1 as a promising postbiotic intervention for metabolic syndrome, providing molecular insights for targeting the insulin/FOXO pathways.
{"title":"Postbiotic Bifidobacterium. breve 207–1 ameliorates high glucose-induced glycolipid metabolic disorders in C. elegans via the daf-2/daf-16 signaling pathway","authors":"Shaolin Huang , Chuan Wu , Can Di , Zhongxia Li , Wenxi Wang , Xiaomeng Wang , Haonan Wang , Fan Huang , Wen Du , Wenya Yin","doi":"10.1016/j.jff.2025.107067","DOIUrl":"10.1016/j.jff.2025.107067","url":null,"abstract":"<div><div>The present study demonstrates that postbiotic <em>Bifidobacterium. breve</em> 207–1 (250, 500, 1000 μg/mL) ameliorates high glucose diet-induced glycolipid metabolic disorders in <em>Caenorhabditis elegans</em> by converging glucose metabolism, lipid homeostasis, and oxidative stress resolution onto the conserved <em>daf-2/daf-16</em> signaling axis. The postbiotic demonstrated a substantial reduction in glucose, glycogen, and triglycerides, while concurrently suppressing ROS/lipofuscin accumulation and extending lifespan. Mechanistically, by inhibiting the insulin receptor <em>daf-2</em> and subsequent activation of the transcription factor <em>daf-16</em>, the postbiotic enhanced glycolytic flux (<em>hxk-2, gpd-2, pyk-2</em>) while concurrently suppressing glycogenesis (<em>gsy-1, pygl-1</em>), promoted β-oxidation (<em>acs-2, cpt-4</em>) yet inhibited lipogenesis (<em>mdt-15/sbp-1, fat-7</em>), and induced antioxidant defense (<em>sod-3</em>), ultimately disrupting the vicious cycle between metabolic dysfunction and oxidative damage. These findings position <em>B. breve</em> 207–1 as a promising postbiotic intervention for metabolic syndrome, providing molecular insights for targeting the insulin/FOXO pathways.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107067"},"PeriodicalIF":4.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1016/j.jff.2025.107068
Hidalgo-Silva Diana Guadalupe , Olvera-Rosales Laura Berenice , Cruz-Guerrero Alma Elizabeth , González-Olivares Luis Guillermo , Castañeda-Ovando Araceli
Probiotic fermented milk is a promising dietary strategy for managing and preventing type 2 diabetes mellitus (T2DM). Probiotics such as Lactobacillus acidophilus, Bifidobacterium lactis, and Lactobacillus casei have shown benefits in glucose metabolism, insulin resistance, and inflammation. Their mechanisms include gut microbiota modulation, production of short-chain fatty acids (SCFAs) like butyrate, which improves insulin sensitivity, and inhibition of digestive enzymes, reducing glucose absorption. These milks contain casein and whey proteins, which release bioactive peptides with antioxidant and glucose-regulating properties upon hydrolysis. Clinical studies suggest that regular consumption can improve blood glucose levels, glycated hemoglobin (HbA1c), and other metabolic markers, though results vary. Challenges include standardization issues, individual variability in response, and the need for long-term studies. This review explores current evidence on the mechanisms and benefits of probiotic fermented milk in diabetes and highlights areas for future research.
{"title":"Probiotic fermented milk and type 2 diabetes mellitus: Mechanisms, benefits, and future directions”","authors":"Hidalgo-Silva Diana Guadalupe , Olvera-Rosales Laura Berenice , Cruz-Guerrero Alma Elizabeth , González-Olivares Luis Guillermo , Castañeda-Ovando Araceli","doi":"10.1016/j.jff.2025.107068","DOIUrl":"10.1016/j.jff.2025.107068","url":null,"abstract":"<div><div>Probiotic fermented milk is a promising dietary strategy for managing and preventing type 2 diabetes mellitus (T2DM). Probiotics such as <em>Lactobacillus acidophilus, Bifidobacterium lactis,</em> and <em>Lactobacillus casei</em> have shown benefits in glucose metabolism, insulin resistance, and inflammation. Their mechanisms include gut microbiota modulation, production of short-chain fatty acids (SCFAs) like butyrate, which improves insulin sensitivity, and inhibition of digestive enzymes, reducing glucose absorption. These milks contain casein and whey proteins, which release bioactive peptides with antioxidant and glucose-regulating properties upon hydrolysis. Clinical studies suggest that regular consumption can improve blood glucose levels, glycated hemoglobin (HbA1c), and other metabolic markers, though results vary. Challenges include standardization issues, individual variability in response, and the need for long-term studies. This review explores current evidence on the mechanisms and benefits of probiotic fermented milk in diabetes and highlights areas for future research.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107068"},"PeriodicalIF":4.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-16DOI: 10.1016/j.jff.2025.107062
Emine Sönmez
Royal jelly (RJ) is a nutrient-rich secretion produced by honeybees, known for its wide range of physiological and pharmacological effects. Comprising a complex mixture of proteins, lipids, vitamins, minerals, polyphenols, and hormones, RJ exhibits significant therapeutic potential across multiple domains of health. Key bioactive constituents such as 10-hydroxy-2(E)-decenoic acid (10-HDA), major royal jelly proteins (MRJPs), royalisin, apisimin, and jelleins are central to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory, anticancer wound-healing, longevity-promoting, and anti-aging effects. By supporting tissue repair and regeneration, RJ shows promise for medical and therapeutic applications. This review highlights the molecular mechanisms behind RJ's diverse biological activities and underscores its potential as a multifunctional therapeutic agent. The findings emphasize the need for further clinical research to validate RJ's efficacy and integrate it into evidence-based medical practice.
{"title":"Royal Jelly in modern biomedicine: A review of its bioactive constituents and health benefits","authors":"Emine Sönmez","doi":"10.1016/j.jff.2025.107062","DOIUrl":"10.1016/j.jff.2025.107062","url":null,"abstract":"<div><div>Royal jelly (RJ) is a nutrient-rich secretion produced by honeybees, known for its wide range of physiological and pharmacological effects. Comprising a complex mixture of proteins, lipids, vitamins, minerals, polyphenols, and hormones, RJ exhibits significant therapeutic potential across multiple domains of health. Key bioactive constituents such as 10-hydroxy-2(<em>E</em>)-decenoic acid (10-HDA), major royal jelly proteins (MRJPs), royalisin, apisimin, and jelleins are central to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory, anticancer wound-healing, longevity-promoting, and anti-aging effects. By supporting tissue repair and regeneration, RJ shows promise for medical and therapeutic applications. This review highlights the molecular mechanisms behind RJ's diverse biological activities and underscores its potential as a multifunctional therapeutic agent. The findings emphasize the need for further clinical research to validate RJ's efficacy and integrate it into evidence-based medical practice.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107062"},"PeriodicalIF":4.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1016/j.jff.2025.107057
Athira Subhash , Lena Labania , Gafar Bamigbade , Ashraf Al-Sbiei , Maria J. Fernandez-Cabezudo , Mutamed M. Ayyash , Basel K. al-Ramadi
This study evaluated the immunomodulatory and gut microbiota-modulating potential of date pomace (DPP) and date seed (DSP) polysaccharides in a preclinical model over 2 weeks (200 μL/day, 4 mg/mL). Flow cytometry analysis of mesenteric lymph nodes revealed no significant changes in immune cell subsets, indicating biocompatibility without disruptive immuno- modulation. Metagenomic sequencing of fecal microbiota revealed dominance of Pseudomonadota, Firmicutes, and Bacteroidetes (>90 %), with DPP/DSP promoting a lowering of Firmicutes-to-Bacteroidetes (F/B) ratio, highlighting their anti-obesogenic potential. Metabolomic analyses (KEGG, COG, MetaCyc) indicated enrichment of carbohydrate degradation associated with short-chain fatty acid (SCFA) production and biosynthesis of amino acids, lipids, coenzymes, and vitamins. Network analyses showed suppression of opportunistic pathogens (Klebsiella oxytoca, Acetatifactor muris) and promotion of SCFA-producing taxa (Bacteroides caecimuris, Limosilactobacillus reuteri), supporting mucosal integrity. These findings suggest DPP and DSP function as prebiotics, promoting a healthy gut microbial diversity, beneficial metabolism, and intestinal homeostasis without perturbing systemic immune profiles.
{"title":"Date byproduct polysaccharides enhance gut health via microbiota-dependent metabolic pathways and immune stability: In-vivo study","authors":"Athira Subhash , Lena Labania , Gafar Bamigbade , Ashraf Al-Sbiei , Maria J. Fernandez-Cabezudo , Mutamed M. Ayyash , Basel K. al-Ramadi","doi":"10.1016/j.jff.2025.107057","DOIUrl":"10.1016/j.jff.2025.107057","url":null,"abstract":"<div><div>This study evaluated the immunomodulatory and gut microbiota-modulating potential of date pomace (DPP) and date seed (DSP) polysaccharides in a preclinical model over 2 weeks (200 μL/day, 4 mg/mL). Flow cytometry analysis of mesenteric lymph nodes revealed no significant changes in immune cell subsets, indicating biocompatibility without disruptive immuno- modulation. Metagenomic sequencing of fecal microbiota revealed dominance of Pseudomonadota, Firmicutes, and Bacteroidetes (>90 %), with DPP/DSP promoting a lowering of Firmicutes-to-Bacteroidetes (F/B) ratio, highlighting their anti-obesogenic potential. Metabolomic analyses (KEGG, COG, MetaCyc) indicated enrichment of carbohydrate degradation associated with short-chain fatty acid (SCFA) production and biosynthesis of amino acids, lipids, coenzymes, and vitamins. Network analyses showed suppression of opportunistic pathogens (<em>Klebsiella oxytoca</em>, <em>Acetatifactor muris</em>) and promotion of SCFA-producing taxa (<em>Bacteroides caecimuris</em>, <em>Limosilactobacillus reuteri</em>), supporting mucosal integrity. These findings suggest DPP and DSP function as prebiotics, promoting a healthy gut microbial diversity, beneficial metabolism, and intestinal homeostasis without perturbing systemic immune profiles.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107057"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1016/j.jff.2025.107058
Kamila Goderska, Peace Oluwamuyiwa Obey
This analysis delves into the combined advantages of synbiotics - a mix of probiotics and prebiotics, in supporting gut health and overall wellness. Synbiotics have displayed potential in enhancing function reducing inflammation and promoting digestion. Research has indicated their effectiveness in managing conditions like rheumatoid arthritis decline in adults, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. Despite their advantages, synbiotics encounter obstacles related to stability and effectiveness, particularly regarding the compatibility of components and the viability of strains. Lactobionic acid (LBA) an acid derived from lactose emerges as an addition to synbiotic formulations due to its antioxidant properties as well as its ability to stabilize and preserve. This examination underscores the benefits of incorporating LBA to enhance the stability and effectiveness of synbiotics urging exploration, through clinical trials to optimize formulation and assess their health impacts. This article is a review of the latest literature in the field of knowledge about synbiotics and lactobionic acid, which can provide a source of growth for probiotic microorganisms. The data presented and discussed in this narrative review were obtained from PubMed, ScienceDirect Scopus (Elsevier) and Web of Science (restricted to the years , 2002 to 2024 with the key words: probiotic, prebiotic and lactobionic acid).
该分析深入研究了益生菌和益生元在支持肠道健康和整体健康方面的综合优势。合成制剂在增强功能、减少炎症和促进消化方面显示出潜力。研究表明，它们对治疗成人类风湿性关节炎、非酒精性脂肪性肝病（NAFLD）和2型糖尿病等疾病有效。尽管具有优势，但合生剂在稳定性和有效性方面遇到了障碍，特别是在组分的相容性和菌株的生存能力方面。乳酸菌酸（LBA）是一种从乳糖中提取的酸，由于其抗氧化特性以及稳定和保存的能力而被添加到合成配方中。本研究强调了加入LBA对增强合生素的稳定性和有效性的益处，敦促探索，通过临床试验来优化配方并评估其对健康的影响。本文综述了合成菌和乳酸菌的最新研究进展，为益生菌微生物的生长提供了新的来源。这篇叙述性综述所呈现和讨论的数据来自PubMed、ScienceDirect Scopus （Elsevier）和Web of Science（限于2002年至2024年，关键词：益生菌、益生元和乳酸）。
{"title":"Characteristics of synbiotics and lactobionic acid","authors":"Kamila Goderska, Peace Oluwamuyiwa Obey","doi":"10.1016/j.jff.2025.107058","DOIUrl":"10.1016/j.jff.2025.107058","url":null,"abstract":"<div><div>This analysis delves into the combined advantages of synbiotics - a mix of probiotics and prebiotics, in supporting gut health and overall wellness. Synbiotics have displayed potential in enhancing function reducing inflammation and promoting digestion. Research has indicated their effectiveness in managing conditions like rheumatoid arthritis decline in adults, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes. Despite their advantages, synbiotics encounter obstacles related to stability and effectiveness, particularly regarding the compatibility of components and the viability of strains. Lactobionic acid (LBA) an acid derived from lactose emerges as an addition to synbiotic formulations due to its antioxidant properties as well as its ability to stabilize and preserve. This examination underscores the benefits of incorporating LBA to enhance the stability and effectiveness of synbiotics urging exploration, through clinical trials to optimize formulation and assess their health impacts. This article is a review of the latest literature in the field of knowledge about synbiotics and lactobionic acid, which can provide a source of growth for probiotic microorganisms. The data presented and discussed in this narrative review were obtained from PubMed, ScienceDirect Scopus (Elsevier) and Web of Science (restricted to the years , 2002 to 2024 with the key words: probiotic, prebiotic and lactobionic acid).</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107058"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1016/j.jff.2025.107051
Xiaoyue Zhang , Yuanyuan Sun , Zixuan Zhang , Xuchun Zhu , Shan He , Linyi Zhou , Mingzheng Huang , Hongzhi Liu
Rosa roxburghii Tratt pomace, a by-product of processing Rosa roxburghii Tratt, constitutes about 45 % of the fresh fruit mass and contains a high proportion of nutritive active ingredients. Therefore, it has important applications in food, cosmetics and medical products. Extensive research has been conducted on the main active components of Rosa roxburghii Tratt pomace, including their content and composition. This paper presents a systematic review of the structure and extraction methods of the active constituents (polysaccharides, dietary fiber, polyphenols and flavonoids, Vitamin C, superoxide dismutase, and other bioactive compounds) in the Rosa roxburghii Tratt pomace. It further summarizes their functional properties and the progress made in applications. This review concludes that these studies can provide references for the future development and utilization of the Rosa roxburghii Tratt pomace, so as to extend the industrial chain, improve the efficiency of resource utilization, reduce environmental pollution, and achieve economic and ecological benefits.
{"title":"A review: Extraction of active ingredients, functional properties of Rosa roxburghii Tratt pomace and its application","authors":"Xiaoyue Zhang , Yuanyuan Sun , Zixuan Zhang , Xuchun Zhu , Shan He , Linyi Zhou , Mingzheng Huang , Hongzhi Liu","doi":"10.1016/j.jff.2025.107051","DOIUrl":"10.1016/j.jff.2025.107051","url":null,"abstract":"<div><div><em>Rosa roxburghii</em> Tratt pomace, a by-product of processing <em>Rosa roxburghii</em> Tratt, constitutes about 45 % of the fresh fruit mass and contains a high proportion of nutritive active ingredients. Therefore, it has important applications in food, cosmetics and medical products. Extensive research has been conducted on the main active components of <em>Rosa roxburghii</em> Tratt pomace, including their content and composition. This paper presents a systematic review of the structure and extraction methods of the active constituents (polysaccharides, dietary fiber, polyphenols and flavonoids, Vitamin C, superoxide dismutase, and other bioactive compounds) in the <em>Rosa roxburghii</em> Tratt pomace. It further summarizes their functional properties and the progress made in applications. This review concludes that these studies can provide references for the future development and utilization of the <em>Rosa roxburghii</em> Tratt pomace, so as to extend the industrial chain, improve the efficiency of resource utilization, reduce environmental pollution, and achieve economic and ecological benefits.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107051"},"PeriodicalIF":4.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-13DOI: 10.1016/j.jff.2025.107063
Junya Takegaki , Takumi Yokokawa , Risako Mori , Daiki Nakano , Aya Matsushita , Seiko Koizumi , Satoshi Fujita
Collagen peptides (CPTs) increase muscle mass with resistance exercise training. However, little is known regarding the effect of CPT administration on anabolic signals in skeletal muscle. In this study, we prepared two types of CPTs, one rich in hydroxyprolyl-glycine (CPT-A) and the other rich in hydroxyprolyl-glycine, prolyl-hydroxyproline, and alanyl-hydroxyprolyl-glycine (CPT–B) and investigated the effects of these peptides on skeletal muscle mTORC1 in mice. Initially, the effects of individual administration of each CPT were investigated. CPT-B increased the expression of phosphorylated rpS6 at 180 min post-administration which was not observed after the administration of whey protein. CPT-A did not induce any significant changes in mTORC1 signaling. Subsequently, their combined effects with whey protein were evaluated. However, the delayed activation was not observed under these conditions. These findings suggest that the CPT-B alone has the potency to activate mTORC1 progressively over time, with a slower onset than whey protein.
{"title":"Effect of collagen peptides rich in hydroxyprolyl-glycine on anabolic signals in mouse skeletal muscle","authors":"Junya Takegaki , Takumi Yokokawa , Risako Mori , Daiki Nakano , Aya Matsushita , Seiko Koizumi , Satoshi Fujita","doi":"10.1016/j.jff.2025.107063","DOIUrl":"10.1016/j.jff.2025.107063","url":null,"abstract":"<div><div>Collagen peptides (CPTs) increase muscle mass with resistance exercise training. However, little is known regarding the effect of CPT administration on anabolic signals in skeletal muscle. In this study, we prepared two types of CPTs, one rich in hydroxyprolyl-glycine (CPT-A) and the other rich in hydroxyprolyl-glycine, prolyl-hydroxyproline, and alanyl-hydroxyprolyl-glycine (CPT–B) and investigated the effects of these peptides on skeletal muscle mTORC1 in mice. Initially, the effects of individual administration of each CPT were investigated. CPT-B increased the expression of phosphorylated rpS6 at 180 min post-administration which was not observed after the administration of whey protein. CPT-A did not induce any significant changes in mTORC1 signaling. Subsequently, their combined effects with whey protein were evaluated. However, the delayed activation was not observed under these conditions. These findings suggest that the CPT-B alone has the potency to activate mTORC1 progressively over time, with a slower onset than whey protein.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107063"},"PeriodicalIF":4.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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