Pub Date : 2023-06-19DOI: 10.2174/2666082219666230619143922
M. Greene, T. Firew, Mara Getz, Eleanor Streicker, P. Thind, Eri Tayama, Kinfu Manzura Lafto, Noah Wubishet Ayele, Tinsae Abera Worku, Ryan Carson, Cécile Fanton d'Andon, T. Yilma, M. Wainberg, Yaregal Fufa
In 2021, more than 23 million people were in need of humanitarian assistance in Ethiopia, including four million internally displaced persons and returnees. Displaced populations face an elevated risk of mental health and psychosocial problems, yet they often have limited access to mental health and psychosocial support. This study aimed to assess: 1) the mental health and psychosocial needs and resources among displaced persons in Ethiopia; and 2) examine barriers, and facilitators, and identify strategies to improve access to culturally appropriate mental health and psychosocial support in this population and context. We conducted a sequential mixed-methods assessment of mental health and psychosocial needs and resources. First, we conducted 16 key informant interviews with those who had experience and knowledge regarding the mental health situation of displaced persons in Ethiopia, including mental health providers and humanitarian practitioners. Second, we conducted an assessment of available mental health services in 15 internally displaced persons (IDP) sites in Ethiopia along with 28 key informant interviews in this context to explore some of the challenges and strategies to improving access to mental health and psychosocial support. Access to mental health services was limited in IDP sites. Participants identified numerous barriers to accessing services that ranged from limited supply and fragmentation of existing mental health services to an incongruence between formal mental health services and explanatory models of mental illness. Strategies to address these barriers included engagement of community members and key stakeholders (e.g., traditional and religious healers), improving mental health literacy, strengthening referral systems and mental health capacity, and improving coordination and integration of mental health within the national health system. This study highlights several challenges and opportunities for improving access to mental health and psychosocial support among displaced persons in Ethiopia. Efforts to bridge gaps in access to mental health and psychosocial support must consider both systems-level factors that influence availability as well as community factors influencing perceptions and acceptability of services within this context.
{"title":"Strategies to improve access to mental health and psychosocial support among displaced populations in Ethiopia","authors":"M. Greene, T. Firew, Mara Getz, Eleanor Streicker, P. Thind, Eri Tayama, Kinfu Manzura Lafto, Noah Wubishet Ayele, Tinsae Abera Worku, Ryan Carson, Cécile Fanton d'Andon, T. Yilma, M. Wainberg, Yaregal Fufa","doi":"10.2174/2666082219666230619143922","DOIUrl":"https://doi.org/10.2174/2666082219666230619143922","url":null,"abstract":"\u0000\u0000In 2021, more than 23 million people were in need of humanitarian assistance in Ethiopia, including four million internally displaced persons and returnees. Displaced populations face an elevated risk of mental health and psychosocial problems, yet they often have limited access to mental health and psychosocial support.\u0000\u0000\u0000\u0000This study aimed to assess: 1) the mental health and psychosocial needs and resources among displaced persons in Ethiopia; and 2) examine barriers, and facilitators, and identify strategies to improve access to culturally appropriate mental health and psychosocial support in this population and context.\u0000\u0000\u0000\u0000We conducted a sequential mixed-methods assessment of mental health and psychosocial needs and resources. First, we conducted 16 key informant interviews with those who had experience and knowledge regarding the mental health situation of displaced persons in Ethiopia, including mental health providers and humanitarian practitioners. Second, we conducted an assessment of available mental health services in 15 internally displaced persons (IDP) sites in Ethiopia along with 28 key informant interviews in this context to explore some of the challenges and strategies to improving access to mental health and psychosocial support.\u0000\u0000\u0000\u0000Access to mental health services was limited in IDP sites. Participants identified numerous barriers to accessing services that ranged from limited supply and fragmentation of existing mental health services to an incongruence between formal mental health services and explanatory models of mental illness. Strategies to address these barriers included engagement of community members and key stakeholders (e.g., traditional and religious healers), improving mental health literacy, strengthening referral systems and mental health capacity, and improving coordination and integration of mental health within the national health system.\u0000\u0000\u0000\u0000This study highlights several challenges and opportunities for improving access to mental health and psychosocial support among displaced persons in Ethiopia. Efforts to bridge gaps in access to mental health and psychosocial support must consider both systems-level factors that influence availability as well as community factors influencing perceptions and acceptability of services within this context.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":"127 14","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41312388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-09DOI: 10.2174/2666082219666230609143447
A. Almaghraby, N. Leelaviwat, Ehab Ismael Dosouky, Mohamed Elsayed, Shadi Ahmed, M. Abdelnabi
In this revisited review, the authors aimed to discuss the general prevalence and burden of depression in patients diagnosed with heart failure. The postulated mechanisms of depression in patients with heart failure, the diagnostic approaches, methods as well as treatment options were all discussed. The safety of depression medications in heart failure patients was also discussed. Through the review of the updated literature and current guidelines, the authors concluded that a team approach is the best way to manage those types of patients.
{"title":"Heart failure and depression: A revisited review","authors":"A. Almaghraby, N. Leelaviwat, Ehab Ismael Dosouky, Mohamed Elsayed, Shadi Ahmed, M. Abdelnabi","doi":"10.2174/2666082219666230609143447","DOIUrl":"https://doi.org/10.2174/2666082219666230609143447","url":null,"abstract":"\u0000\u0000In this revisited review, the authors aimed to discuss the general prevalence and burden of depression in patients diagnosed with heart failure. The postulated mechanisms of depression in patients with heart failure, the diagnostic approaches, methods as well as treatment options were all discussed. The safety of depression medications in heart failure patients was also discussed. Through the review of the updated literature and current guidelines, the authors concluded that a team approach is the best way to manage those types of patients.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42848194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-19DOI: 10.2174/2666082219666230519102418
Sergio Rojtenbrg, Daniel Mosca, Maria Fernanda Verdaguer, Monica Martinez, Paola M. Elorza
Background: Despite the huge global socioeconomic burden of depressive disorders, depression is often underreported and undertreated due to a lower level of awareness from both healthcare providers and payers in many countries. The lack of an evidence-based approach to care delivery has resulted in the inequitable allocation of health resources, causing resource scarcity issues in Argentina. Objective: The aim of this paper is to identify the gaps in evidence related to patients’ journeys and barriers in the existing care ecosystem contributing to poor access to quality care for depression in an Argentine context. Methods: A semi-systematic review of the literature was performed from 2012 to 2021 using Medline, Embase and Biosis and other unstructured sources (Google Scholar, the World Health Organization (WHO) website, Argentina Ministry of Health website, and Incidence and Prevalence Database (IPD) on awareness, screening, diagnosis, treatment, adherence and/or control of depression amongst adults (≥18 years). Any identified data gaps were supplemented with anecdotal data from local experts. Results: Low percentages of adult patients with depression awareness (<25%), screening (<10%), diagnosis (37.5%), received treatment (41.9%), adherence to treatment (37.5%), and control (37.5%) were observed. Conclusion: Ensuring a care continuum while considering full clinical remission with functional recovery as a therapeutic goal and advocacy for patient-centric adjustments in existing mental health policies would be key drivers for improving the depression care scenario.
{"title":"The Winding Path of Depression in Argentina from Awareness to Functional Recovery","authors":"Sergio Rojtenbrg, Daniel Mosca, Maria Fernanda Verdaguer, Monica Martinez, Paola M. Elorza","doi":"10.2174/2666082219666230519102418","DOIUrl":"https://doi.org/10.2174/2666082219666230519102418","url":null,"abstract":"Background: Despite the huge global socioeconomic burden of depressive disorders, depression is often underreported and undertreated due to a lower level of awareness from both healthcare providers and payers in many countries. The lack of an evidence-based approach to care delivery has resulted in the inequitable allocation of health resources, causing resource scarcity issues in Argentina. Objective: The aim of this paper is to identify the gaps in evidence related to patients’ journeys and barriers in the existing care ecosystem contributing to poor access to quality care for depression in an Argentine context. Methods: A semi-systematic review of the literature was performed from 2012 to 2021 using Medline, Embase and Biosis and other unstructured sources (Google Scholar, the World Health Organization (WHO) website, Argentina Ministry of Health website, and Incidence and Prevalence Database (IPD) on awareness, screening, diagnosis, treatment, adherence and/or control of depression amongst adults (≥18 years). Any identified data gaps were supplemented with anecdotal data from local experts. Results: Low percentages of adult patients with depression awareness (<25%), screening (<10%), diagnosis (37.5%), received treatment (41.9%), adherence to treatment (37.5%), and control (37.5%) were observed. Conclusion: Ensuring a care continuum while considering full clinical remission with functional recovery as a therapeutic goal and advocacy for patient-centric adjustments in existing mental health policies would be key drivers for improving the depression care scenario.","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135631398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-18DOI: 10.2174/2666082219666230518105004
R. Balatif, Alshafiera Azayyana Mawadhani Sukma
Depression is a mental disorder that affects 279 million people. Patients with depression will not only have an impact on themselves but can also have an impact on others. Provide an overview of the impact of depression on health workers, workers, students and patients, as well as the prevention of depression. Data on the impact of depression and its prevention using the Google Scholar and Pubmed search engine. Depression in healthcare workers can affect the occurrence of misdiagnosis of a patient's disease, reduce the quality of service, and increase the risk of suicide. Depression in other workers can result in lost productivity and income, absenteeism, presenteeism, and accidents in the workplace. Depression in students causes decreased student achievement, difficulties concentrating and social interactions, and absenteeism. In patients with physical illness, depression can increase the risk of mortality, re-hospitalization, higher costs, poor treatment adherence, and lost follow-up. Depression prevention can help lower the risk of depression by up to 21%. This prevention must be done as early as possible and starts from the scope of prevention at the family level. Then this prevention can be done individually, especially for those with a high risk of experiencing depression. The last prevention is universal prevention (population) which can be started by educating the community Depression can happen to anyone and will have a detrimental impact on themselves and others. Prevention of depression should be done as early as possible to prevent the impacts of depression.
{"title":"Depression and Its Impact on Various Aspects of Life – A Narrative Review","authors":"R. Balatif, Alshafiera Azayyana Mawadhani Sukma","doi":"10.2174/2666082219666230518105004","DOIUrl":"https://doi.org/10.2174/2666082219666230518105004","url":null,"abstract":"\u0000\u0000Depression is a mental disorder that affects 279 million people. Patients with depression will not only have an impact on themselves but can also have an impact on others.\u0000\u0000\u0000\u0000Provide an overview of the impact of depression on health workers, workers, students and patients, as well as the prevention of depression.\u0000\u0000\u0000\u0000Data on the impact of depression and its prevention using the Google Scholar and Pubmed search engine.\u0000\u0000\u0000\u0000Depression in healthcare workers can affect the occurrence of misdiagnosis of a patient's disease, reduce the quality of service, and increase the risk of suicide. Depression in other workers can result in lost productivity and income, absenteeism, presenteeism, and accidents in the workplace. Depression in students causes decreased student achievement, difficulties concentrating and social interactions, and absenteeism. In patients with physical illness, depression can increase the risk of mortality, re-hospitalization, higher costs, poor treatment adherence, and lost follow-up. Depression prevention can help lower the risk of depression by up to 21%. This prevention must be done as early as possible and starts from the scope of prevention at the family level. Then this prevention can be done individually, especially for those with a high risk of experiencing depression. The last prevention is universal prevention (population) which can be started by educating the community\u0000\u0000\u0000\u0000Depression can happen to anyone and will have a detrimental impact on themselves and others. Prevention of depression should be done as early as possible to prevent the impacts of depression.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42355225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Substance use disorders (SUDs) contribute to one-fifth of all disability-adjusted life years caused by psychiatric illnesses. They have a high treatment gap. Stigma affects the lives of people with SUDs and is shown to impede the pursuit of valued life goals and recovery from addiction. We studied stigma and QOL in patients with Alcohol Use disorders (AUD). Participants between 18 and 65 years with a clinical diagnosis of AUD were included (inpatients and outpatients). Demographic and clinical data were recorded using a semi-structured questionnaire. ISMIS & WHOQOL-Bref questionnaires were used to assess internalized stigma and quality of life. Of the 141 participants, 89(63.10%) patients had severe self-stigma, 31(22.10%) patients had moderate self-stigma, and 21(14.90) patients had mild self-stigma. In ISMIS, stigma due to alienation (3.22) was higher than social withdrawal, discrimination, stereotype, and stigma resistance. In the WHOQOL-Bref questionnaire, the mean score of social domain (9.45) was the lowest compared to the other domains of the quality of life scale. A significant association was found between the education and the duration of substance use with ISMI grades with people with up to 10th standard education (p-value - 0.002*), living in urban areas (p-value - 0.022*), and ten or more years of substance use (p-value - 0.00002). The various domains of quality of life generally negatively correlated with the internalized stigma score, suggesting that a greater degree of self-stigma is associated with poorer quality of life.
{"title":"Internalized Stigma and Quality of Life in Patients With Alcohol Use Disorder: A Cross-Sectional Study From Gujarat, India","authors":"Saumitra Nemlekar, Urvika Parekh, Rakesh Gandhi, Dhruv Bardolia","doi":"10.2174/2666082219666230517141308","DOIUrl":"https://doi.org/10.2174/2666082219666230517141308","url":null,"abstract":"\u0000\u0000Substance use disorders (SUDs) contribute to one-fifth of all disability-adjusted life years caused by psychiatric illnesses. They have a high treatment gap. Stigma affects the lives of people with SUDs and is shown to impede the pursuit of valued life goals and recovery from addiction. We studied stigma and QOL in patients with Alcohol Use disorders (AUD).\u0000\u0000\u0000\u0000Participants between 18 and 65 years with a clinical diagnosis of AUD were included (inpatients and outpatients). Demographic and clinical data were recorded using a semi-structured questionnaire. ISMIS & WHOQOL-Bref questionnaires were used to assess internalized stigma and quality of life.\u0000\u0000\u0000\u0000Of the 141 participants, 89(63.10%) patients had severe self-stigma, 31(22.10%) patients had moderate self-stigma, and 21(14.90) patients had mild self-stigma. In ISMIS, stigma due to alienation (3.22) was higher than social withdrawal, discrimination, stereotype, and stigma resistance. In the WHOQOL-Bref questionnaire, the mean score of social domain (9.45) was the lowest compared to the other domains of the quality of life scale. A significant association was found between the education and the duration of substance use with ISMI grades with people with up to 10th standard education (p-value - 0.002*), living in urban areas (p-value - 0.022*), and ten or more years of substance use (p-value - 0.00002).\u0000\u0000\u0000\u0000The various domains of quality of life generally negatively correlated with the internalized stigma score, suggesting that a greater degree of self-stigma is associated with poorer quality of life.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":"55 3","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41305767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-16DOI: 10.2174/2666082219666230516155749
M. Bahreini, Amirmasoud Kazemzadeh Houjaghan, Pantea Arya, Sepide Aarabi, H. Ashraf
Due to the high transmission rate of COVID-19, the high prevalence of the disease, the high mortality rate, and its effects on mental health, we aimed to assess the current status of psychiatric symptoms. In this observational study, we have assessed various psychiatric presentations and disorders before and after the COVID-19 pandemic within the same time limit. Data have been obtained from the psychiatric interview performed by an attending physician in psychiatry. The following features have been observed after the pandemic: increased depressed mood, irritability, crime trend, physical violations, personality disorders along with improved family support, and decreased suicidal ideation. No significant difference has been observed in the rate of response to psychotherapy and psychiatric medications before and after the time of the pandemic. Increased physical threat and aggression, substance use, and symptoms of psychosis were more frequently observed in the time of the pandemic. The physical threat was mainly committed by younger patients with psychiatric illnesses.
{"title":"Assessment of Patients' Referral Patterns with Complains of Self-harm and Aggression in the COVID-19 Era","authors":"M. Bahreini, Amirmasoud Kazemzadeh Houjaghan, Pantea Arya, Sepide Aarabi, H. Ashraf","doi":"10.2174/2666082219666230516155749","DOIUrl":"https://doi.org/10.2174/2666082219666230516155749","url":null,"abstract":"\u0000\u0000Due to the high transmission rate of COVID-19, the high prevalence of the disease, the high mortality rate, and its effects on mental health, we aimed to assess the current status of psychiatric symptoms.\u0000\u0000\u0000\u0000In this observational study, we have assessed various psychiatric presentations and disorders before and after the COVID-19 pandemic within the same time limit. Data have been obtained from the psychiatric interview performed by an attending physician in psychiatry.\u0000\u0000\u0000\u0000The following features have been observed after the pandemic: increased depressed mood, irritability, crime trend, physical violations, personality disorders along with improved family support, and decreased suicidal ideation. No significant difference has been observed in the rate of response to psychotherapy and psychiatric medications before and after the time of the pandemic.\u0000\u0000\u0000\u0000Increased physical threat and aggression, substance use, and symptoms of psychosis were more frequently observed in the time of the pandemic. The physical threat was mainly committed by younger patients with psychiatric illnesses.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47683451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.2174/2666082219666230418112434
V. Trkulja
{"title":"A few methodological points in candidate gene associations studies in psychiatry with a case study","authors":"V. Trkulja","doi":"10.2174/2666082219666230418112434","DOIUrl":"https://doi.org/10.2174/2666082219666230418112434","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47642321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.2174/2666082219666230418090309
E. Darin
The study of autoaggression is one of the main areas of research work in psychiatry, suicidology, and psychology. Suicidal behavior remains one of the most dangerous forms of autoaggressive behavior. In recent years, both in Russia, and around the world, there has been an increased interest in the problem of non-suicidal injuries. This review aims to analyze, summarize, and present definitions of autoaggression, suicidal behavior, and self-harm that are relevant among Russian authors, as well as present long-term results of dissertation research by Russian authors on this topic. A non-systematic narrative review is presented. In the first section, a search was made for Russian-language, and English-language sources in the databases: ELibrary.ru, PubMed, and the “google scholar” search system. Articles were searched by keywords: SelfInjurious Behavior Suicide Suicidal Ideation Suicide, Attempted, autoaggression, self-harm, and adolescents. In the second section, a search and analysis of dissertation research by Russian authors from 2000 to 2020 are carried out using the database of the Russian State Library. On this topic, a total of 86 papers were found, of which 66 theses directly study these issues, 8 theses have information on this topic in the results and conclusions, and 12 theses were excluded from the results as not relevant. The story is arranged in chronological order from oldest to newest. Abstracts of dissertations are used for citation. The behavior of an autoaggressive nature, self-injurious behavior, and non-suicidal self-harm is currently a phenomenon that is widespread among adolescents. Currently, NSSI is an urgent problem of mental health among adolescents.
{"title":"Auto-aggressive Behavior as a Medical and Social Problem of Our\u0000Time: Definitions, Concepts, and Retrospective of Research by\u0000Russian Authors, Narrative Review","authors":"E. Darin","doi":"10.2174/2666082219666230418090309","DOIUrl":"https://doi.org/10.2174/2666082219666230418090309","url":null,"abstract":"\u0000\u0000The study of autoaggression is one of the main areas of research work\u0000in psychiatry, suicidology, and psychology. Suicidal behavior remains one of the most dangerous forms of autoaggressive behavior. In recent years, both in Russia, and around the world,\u0000there has been an increased interest in the problem of non-suicidal injuries.\u0000\u0000\u0000\u0000This review aims to analyze, summarize, and present definitions of autoaggression,\u0000suicidal behavior, and self-harm that are relevant among Russian authors, as well as present\u0000long-term results of dissertation research by Russian authors on this topic.\u0000\u0000\u0000\u0000A non-systematic narrative review is presented. In the first section, a search was\u0000made for Russian-language, and English-language sources in the databases: ELibrary.ru, PubMed, and the “google scholar” search system. Articles were searched by keywords: SelfInjurious Behavior Suicide Suicidal Ideation Suicide, Attempted, autoaggression, self-harm,\u0000and adolescents. In the second section, a search and analysis of dissertation research by Russian authors from 2000 to 2020 are carried out using the database of the Russian State Library.\u0000On this topic, a total of 86 papers were found, of which 66 theses directly study these issues, 8\u0000theses have information on this topic in the results and conclusions, and 12 theses were excluded from the results as not relevant. The story is arranged in chronological order from oldest to\u0000newest. Abstracts of dissertations are used for citation.\u0000\u0000\u0000\u0000The behavior of an autoaggressive nature, self-injurious behavior, and non-suicidal\u0000self-harm is currently a phenomenon that is widespread among adolescents. Currently, NSSI is\u0000an urgent problem of mental health among adolescents.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45381498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.2174/2666082219666230320153841
Soumitra Nath
Havana syndrome cases increased in Cuba at the end of 2016 and early 2017, and the consequences ranged from minor to severe health concerns. In almost all affected individuals, symptoms like difficulty-concentrating, visual issues, brain-fog, memory problems, tinnitus, and sleep-related complaints were reported. Some initial studies pointed the causative possibility towards energy weapons, ultrasound, microwaves, microbes and chemicals. However, to date, no study has provided a comprehensive explanation of this sudden mysterious syndrome, and the root cause remains unexplained.
{"title":"Havana Syndrome: A Mysterious Illness or a New Domain of Warfare","authors":"Soumitra Nath","doi":"10.2174/2666082219666230320153841","DOIUrl":"https://doi.org/10.2174/2666082219666230320153841","url":null,"abstract":"\u0000\u0000Havana syndrome cases increased in Cuba at the end of 2016 and early 2017, and the consequences ranged from minor to severe health concerns. In almost all affected individuals, symptoms like difficulty-concentrating, visual issues, brain-fog, memory problems, tinnitus, and sleep-related complaints were reported. Some initial studies pointed the causative possibility towards energy weapons, ultrasound, microwaves, microbes and chemicals. However, to date, no study has provided a comprehensive explanation of this sudden mysterious syndrome, and the root cause remains unexplained.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47932911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.2174/2666082219666230320151355
Chakresh Kumar Jain, Khushi R. Mittal, Nandini Jain, Swati Mittal
Within a decade the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9 system), an advanced gene-editing technology became one of the celebrated approaches in modern disease therapeutics and was reported to have a potential role in the alteration of non-coding RNAs segment which are the pivotal causes behind the several mental disorder such as Schizophrenia. In general, Schizophrenia is referred as a neurodevelopmental disorder and symptomatically exhibited by social deficit, cognitive dysfunction, apathy, delusions, hallucinations, etc. At a genomics level large number of loci are susceptible for genetic alteration in schizophrenia and are mostly located in the genome’s non-coding region. With the growing variants and mutations in ncRNA genes (miRNA and lncRNA) strongly associated with schizophrenia, the need to develop a genetic tool to help with the treatment and study of schizophrenia increases. Recently the use of CRISPR/cas9 technology in the productive alteration of non-coding RNAs genes such as miRNA; miR-291, miR-141, and miR-21, lncRNA, lncRNA-21A, AK023948, and LncRNA Rian has been reported. The Cas9 protein and guide RNA (gRNA) together form the CRISPR/Cas9 system is known to be highly specific and efficient for manipulating the impact of gene mutations linked to genomic DNA like ncRNA besides other inheritable genetic diseases. Copy number variations are also found to be linked with schizophrenia. The generation of reciprocal CNVs of 15q13.3 and 16p11.2 in human-induced pluripotent stem cells (iPSCs) with the CRISPR/Cas 9 system has opened new possibilities. Still, there are some limitations and challenges yet to be defeated, like the blood-brain barrier poses an obstacle to treating mental disorders and ethical issues like genomic DNA manipulation of eggs and embryos. This review brings schizophrenia-associated ncRNAs and CRISPR gene-editing technology for the non-coding parts of the genomic DNA together and recent challenges.
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