Substance use disorders (SUDs) contribute to one-fifth of all disability-adjusted life years caused by psychiatric illnesses. They have a high treatment gap. Stigma affects the lives of people with SUDs and is shown to impede the pursuit of valued life goals and recovery from addiction. We studied stigma and QOL in patients with Alcohol Use disorders (AUD). Participants between 18 and 65 years with a clinical diagnosis of AUD were included (inpatients and outpatients). Demographic and clinical data were recorded using a semi-structured questionnaire. ISMIS & WHOQOL-Bref questionnaires were used to assess internalized stigma and quality of life. Of the 141 participants, 89(63.10%) patients had severe self-stigma, 31(22.10%) patients had moderate self-stigma, and 21(14.90) patients had mild self-stigma. In ISMIS, stigma due to alienation (3.22) was higher than social withdrawal, discrimination, stereotype, and stigma resistance. In the WHOQOL-Bref questionnaire, the mean score of social domain (9.45) was the lowest compared to the other domains of the quality of life scale. A significant association was found between the education and the duration of substance use with ISMI grades with people with up to 10th standard education (p-value - 0.002*), living in urban areas (p-value - 0.022*), and ten or more years of substance use (p-value - 0.00002). The various domains of quality of life generally negatively correlated with the internalized stigma score, suggesting that a greater degree of self-stigma is associated with poorer quality of life.
{"title":"Internalized Stigma and Quality of Life in Patients With Alcohol Use Disorder: A Cross-Sectional Study From Gujarat, India","authors":"Saumitra Nemlekar, Urvika Parekh, Rakesh Gandhi, Dhruv Bardolia","doi":"10.2174/2666082219666230517141308","DOIUrl":"https://doi.org/10.2174/2666082219666230517141308","url":null,"abstract":"\u0000\u0000Substance use disorders (SUDs) contribute to one-fifth of all disability-adjusted life years caused by psychiatric illnesses. They have a high treatment gap. Stigma affects the lives of people with SUDs and is shown to impede the pursuit of valued life goals and recovery from addiction. We studied stigma and QOL in patients with Alcohol Use disorders (AUD).\u0000\u0000\u0000\u0000Participants between 18 and 65 years with a clinical diagnosis of AUD were included (inpatients and outpatients). Demographic and clinical data were recorded using a semi-structured questionnaire. ISMIS & WHOQOL-Bref questionnaires were used to assess internalized stigma and quality of life.\u0000\u0000\u0000\u0000Of the 141 participants, 89(63.10%) patients had severe self-stigma, 31(22.10%) patients had moderate self-stigma, and 21(14.90) patients had mild self-stigma. In ISMIS, stigma due to alienation (3.22) was higher than social withdrawal, discrimination, stereotype, and stigma resistance. In the WHOQOL-Bref questionnaire, the mean score of social domain (9.45) was the lowest compared to the other domains of the quality of life scale. A significant association was found between the education and the duration of substance use with ISMI grades with people with up to 10th standard education (p-value - 0.002*), living in urban areas (p-value - 0.022*), and ten or more years of substance use (p-value - 0.00002).\u0000\u0000\u0000\u0000The various domains of quality of life generally negatively correlated with the internalized stigma score, suggesting that a greater degree of self-stigma is associated with poorer quality of life.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41305767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-16DOI: 10.2174/2666082219666230516155749
M. Bahreini, Amirmasoud Kazemzadeh Houjaghan, Pantea Arya, Sepide Aarabi, H. Ashraf
Due to the high transmission rate of COVID-19, the high prevalence of the disease, the high mortality rate, and its effects on mental health, we aimed to assess the current status of psychiatric symptoms. In this observational study, we have assessed various psychiatric presentations and disorders before and after the COVID-19 pandemic within the same time limit. Data have been obtained from the psychiatric interview performed by an attending physician in psychiatry. The following features have been observed after the pandemic: increased depressed mood, irritability, crime trend, physical violations, personality disorders along with improved family support, and decreased suicidal ideation. No significant difference has been observed in the rate of response to psychotherapy and psychiatric medications before and after the time of the pandemic. Increased physical threat and aggression, substance use, and symptoms of psychosis were more frequently observed in the time of the pandemic. The physical threat was mainly committed by younger patients with psychiatric illnesses.
{"title":"Assessment of Patients' Referral Patterns with Complains of Self-harm and Aggression in the COVID-19 Era","authors":"M. Bahreini, Amirmasoud Kazemzadeh Houjaghan, Pantea Arya, Sepide Aarabi, H. Ashraf","doi":"10.2174/2666082219666230516155749","DOIUrl":"https://doi.org/10.2174/2666082219666230516155749","url":null,"abstract":"\u0000\u0000Due to the high transmission rate of COVID-19, the high prevalence of the disease, the high mortality rate, and its effects on mental health, we aimed to assess the current status of psychiatric symptoms.\u0000\u0000\u0000\u0000In this observational study, we have assessed various psychiatric presentations and disorders before and after the COVID-19 pandemic within the same time limit. Data have been obtained from the psychiatric interview performed by an attending physician in psychiatry.\u0000\u0000\u0000\u0000The following features have been observed after the pandemic: increased depressed mood, irritability, crime trend, physical violations, personality disorders along with improved family support, and decreased suicidal ideation. No significant difference has been observed in the rate of response to psychotherapy and psychiatric medications before and after the time of the pandemic.\u0000\u0000\u0000\u0000Increased physical threat and aggression, substance use, and symptoms of psychosis were more frequently observed in the time of the pandemic. The physical threat was mainly committed by younger patients with psychiatric illnesses.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47683451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.2174/2666082219666230418112434
V. Trkulja
{"title":"A few methodological points in candidate gene associations studies in psychiatry with a case study","authors":"V. Trkulja","doi":"10.2174/2666082219666230418112434","DOIUrl":"https://doi.org/10.2174/2666082219666230418112434","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47642321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.2174/2666082219666230418090309
E. Darin
The study of autoaggression is one of the main areas of research work in psychiatry, suicidology, and psychology. Suicidal behavior remains one of the most dangerous forms of autoaggressive behavior. In recent years, both in Russia, and around the world, there has been an increased interest in the problem of non-suicidal injuries. This review aims to analyze, summarize, and present definitions of autoaggression, suicidal behavior, and self-harm that are relevant among Russian authors, as well as present long-term results of dissertation research by Russian authors on this topic. A non-systematic narrative review is presented. In the first section, a search was made for Russian-language, and English-language sources in the databases: ELibrary.ru, PubMed, and the “google scholar” search system. Articles were searched by keywords: SelfInjurious Behavior Suicide Suicidal Ideation Suicide, Attempted, autoaggression, self-harm, and adolescents. In the second section, a search and analysis of dissertation research by Russian authors from 2000 to 2020 are carried out using the database of the Russian State Library. On this topic, a total of 86 papers were found, of which 66 theses directly study these issues, 8 theses have information on this topic in the results and conclusions, and 12 theses were excluded from the results as not relevant. The story is arranged in chronological order from oldest to newest. Abstracts of dissertations are used for citation. The behavior of an autoaggressive nature, self-injurious behavior, and non-suicidal self-harm is currently a phenomenon that is widespread among adolescents. Currently, NSSI is an urgent problem of mental health among adolescents.
{"title":"Auto-aggressive Behavior as a Medical and Social Problem of Our\u0000Time: Definitions, Concepts, and Retrospective of Research by\u0000Russian Authors, Narrative Review","authors":"E. Darin","doi":"10.2174/2666082219666230418090309","DOIUrl":"https://doi.org/10.2174/2666082219666230418090309","url":null,"abstract":"\u0000\u0000The study of autoaggression is one of the main areas of research work\u0000in psychiatry, suicidology, and psychology. Suicidal behavior remains one of the most dangerous forms of autoaggressive behavior. In recent years, both in Russia, and around the world,\u0000there has been an increased interest in the problem of non-suicidal injuries.\u0000\u0000\u0000\u0000This review aims to analyze, summarize, and present definitions of autoaggression,\u0000suicidal behavior, and self-harm that are relevant among Russian authors, as well as present\u0000long-term results of dissertation research by Russian authors on this topic.\u0000\u0000\u0000\u0000A non-systematic narrative review is presented. In the first section, a search was\u0000made for Russian-language, and English-language sources in the databases: ELibrary.ru, PubMed, and the “google scholar” search system. Articles were searched by keywords: SelfInjurious Behavior Suicide Suicidal Ideation Suicide, Attempted, autoaggression, self-harm,\u0000and adolescents. In the second section, a search and analysis of dissertation research by Russian authors from 2000 to 2020 are carried out using the database of the Russian State Library.\u0000On this topic, a total of 86 papers were found, of which 66 theses directly study these issues, 8\u0000theses have information on this topic in the results and conclusions, and 12 theses were excluded from the results as not relevant. The story is arranged in chronological order from oldest to\u0000newest. Abstracts of dissertations are used for citation.\u0000\u0000\u0000\u0000The behavior of an autoaggressive nature, self-injurious behavior, and non-suicidal\u0000self-harm is currently a phenomenon that is widespread among adolescents. Currently, NSSI is\u0000an urgent problem of mental health among adolescents.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45381498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.2174/2666082219666230320153841
Soumitra Nath
Havana syndrome cases increased in Cuba at the end of 2016 and early 2017, and the consequences ranged from minor to severe health concerns. In almost all affected individuals, symptoms like difficulty-concentrating, visual issues, brain-fog, memory problems, tinnitus, and sleep-related complaints were reported. Some initial studies pointed the causative possibility towards energy weapons, ultrasound, microwaves, microbes and chemicals. However, to date, no study has provided a comprehensive explanation of this sudden mysterious syndrome, and the root cause remains unexplained.
{"title":"Havana Syndrome: A Mysterious Illness or a New Domain of Warfare","authors":"Soumitra Nath","doi":"10.2174/2666082219666230320153841","DOIUrl":"https://doi.org/10.2174/2666082219666230320153841","url":null,"abstract":"\u0000\u0000Havana syndrome cases increased in Cuba at the end of 2016 and early 2017, and the consequences ranged from minor to severe health concerns. In almost all affected individuals, symptoms like difficulty-concentrating, visual issues, brain-fog, memory problems, tinnitus, and sleep-related complaints were reported. Some initial studies pointed the causative possibility towards energy weapons, ultrasound, microwaves, microbes and chemicals. However, to date, no study has provided a comprehensive explanation of this sudden mysterious syndrome, and the root cause remains unexplained.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47932911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.2174/2666082219666230320151355
Chakresh Kumar Jain, Khushi R. Mittal, Nandini Jain, Swati Mittal
Within a decade the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9 system), an advanced gene-editing technology became one of the celebrated approaches in modern disease therapeutics and was reported to have a potential role in the alteration of non-coding RNAs segment which are the pivotal causes behind the several mental disorder such as Schizophrenia. In general, Schizophrenia is referred as a neurodevelopmental disorder and symptomatically exhibited by social deficit, cognitive dysfunction, apathy, delusions, hallucinations, etc. At a genomics level large number of loci are susceptible for genetic alteration in schizophrenia and are mostly located in the genome’s non-coding region. With the growing variants and mutations in ncRNA genes (miRNA and lncRNA) strongly associated with schizophrenia, the need to develop a genetic tool to help with the treatment and study of schizophrenia increases. Recently the use of CRISPR/cas9 technology in the productive alteration of non-coding RNAs genes such as miRNA; miR-291, miR-141, and miR-21, lncRNA, lncRNA-21A, AK023948, and LncRNA Rian has been reported. The Cas9 protein and guide RNA (gRNA) together form the CRISPR/Cas9 system is known to be highly specific and efficient for manipulating the impact of gene mutations linked to genomic DNA like ncRNA besides other inheritable genetic diseases. Copy number variations are also found to be linked with schizophrenia. The generation of reciprocal CNVs of 15q13.3 and 16p11.2 in human-induced pluripotent stem cells (iPSCs) with the CRISPR/Cas 9 system has opened new possibilities. Still, there are some limitations and challenges yet to be defeated, like the blood-brain barrier poses an obstacle to treating mental disorders and ethical issues like genomic DNA manipulation of eggs and embryos. This review brings schizophrenia-associated ncRNAs and CRISPR gene-editing technology for the non-coding parts of the genomic DNA together and recent challenges.
{"title":"CRISPR/Cas9 Technology for Non-Coding Gene Editing in Schizophrenia Therapeutics: The Recent Progress And Challenges","authors":"Chakresh Kumar Jain, Khushi R. Mittal, Nandini Jain, Swati Mittal","doi":"10.2174/2666082219666230320151355","DOIUrl":"https://doi.org/10.2174/2666082219666230320151355","url":null,"abstract":"\u0000\u0000Within a decade the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9 system), an advanced gene-editing technology became one of the celebrated approaches in modern disease therapeutics and was reported to have a potential role in the alteration of non-coding RNAs segment which are the pivotal causes behind the several mental disorder such as Schizophrenia. \u0000 \u0000In general, Schizophrenia is referred as a neurodevelopmental disorder and symptomatically exhibited by social deficit, cognitive dysfunction, apathy, delusions, hallucinations, etc. At a genomics level large number of loci are susceptible for genetic alteration in schizophrenia and are mostly located in the genome’s non-coding region. With the growing variants and mutations in ncRNA genes (miRNA and lncRNA) strongly associated with schizophrenia, the need to develop a genetic tool to help with the treatment and study of schizophrenia increases. Recently the use of CRISPR/cas9 technology in the productive alteration of non-coding RNAs genes such as miRNA; miR-291, miR-141, and miR-21, lncRNA, lncRNA-21A, AK023948, and LncRNA Rian has been reported. The Cas9 protein and guide RNA (gRNA) together form the CRISPR/Cas9 system is known to be highly specific and efficient for manipulating the impact of gene mutations linked to genomic DNA like ncRNA besides other inheritable genetic diseases. Copy number variations are also found to be linked with schizophrenia. The generation of reciprocal CNVs of 15q13.3 and 16p11.2 in human-induced pluripotent stem cells (iPSCs) with the CRISPR/Cas 9 system has opened new possibilities. Still, there are some limitations and challenges yet to be defeated, like the blood-brain barrier poses an obstacle to treating mental disorders and ethical issues like genomic DNA manipulation of eggs and embryos. This review brings schizophrenia-associated ncRNAs and CRISPR gene-editing technology for the non-coding parts of the genomic DNA together and recent challenges.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46548168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-16DOI: 10.2174/2666082219666230316144225
P. Theofilou
Parental stress and depression are factors that significantly affect the exercise of the parental role and have an impact on the upbringing of children and their quality of life. The purpose of this study is to investigate the differences between the dependent variables of quality of life, anxiety and depression in relation to the demographic characteristics, as an independent variable, in the entire sample before the implementation of parent counseling. A sample of 160 parents was collected to participate. The psychometric tools have been used are: The Spielberger Stress Trait Anxiety Inventory (STAI), the Beck depression Inventory (BDI), and the Health and well-being Questionnaire (The RAND 36-Item Healthy Survey, SF-36, Version 1.0). It was found that men have better quality of life in both physical and emotional health, lower anxiety and depression. A positive correlation between age and emotional health was found. Younger parents have more anxiety, depression and generally poorer emotional health than older parents. It was found that men have better quality of life in both physical and emotional health, lower anxiety and depression. A positive correlation between age and emotional health was found. Younger parents have more anxiety, depression and generally poorer emotional health than older parents.
{"title":"Anxiety, Depression and Quality of Life among Parents Attending School Counseling Programs: Are they Effected by Sociodemographic Characteristics?","authors":"P. Theofilou","doi":"10.2174/2666082219666230316144225","DOIUrl":"https://doi.org/10.2174/2666082219666230316144225","url":null,"abstract":"\u0000\u0000Parental stress and depression are factors that significantly affect the exercise of the parental role and have an impact on the upbringing of children and their quality of life. The purpose of this study is to investigate the differences between the dependent variables of quality of life, anxiety and depression in relation to the demographic characteristics, as an independent variable, in the entire sample before the implementation of parent counseling. A sample of 160 parents was collected to participate. The psychometric tools have been used are: The Spielberger Stress Trait Anxiety Inventory (STAI), the Beck depression Inventory (BDI), and the Health and well-being Questionnaire (The RAND 36-Item Healthy Survey, SF-36, Version 1.0). It was found that men have better quality of life in both physical and emotional health, lower anxiety and depression. A positive correlation between age and emotional health was found. Younger parents have more anxiety, depression and generally poorer emotional health than older parents.\u0000\u0000\u0000\u0000It was found that men have better quality of life in both physical and emotional health, lower anxiety and depression. A positive correlation between age and emotional health was found. Younger parents have more anxiety, depression and generally poorer emotional health than older parents.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42962967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-02DOI: 10.2174/2666082219666230302142608
Rajat Hegde, P. Gai, Smita Hegde, S. Kulkarni, Kusal K. Das
Oxidative stress is an imbalance between an organism's reactive oxygen species [ROS] production and antioxidant defence capacity. Long-term oxidative stress contributes to cellular ageing and plays a role in the pathogenesis of several diseases. Several investigations indicated that oxidative stress has a role in the pathogenesis of ASD. Present study was undertaken to record the association of GSTTT1 and GSTM1 null genotype among the autistic population of India. Genomic DNA was isolated from 108 autistic children along with healthy age-matched control. The quality and quantity of the isolated genomic DNA were analysed. GSTT1 and GSTM1 null genotype was analysed using polymerase chain reaction with internal positive control. Statistical analysis was performed using SPSS 15.0. Present study included 85 males and 23 females with a mean age of 11.7±3.5 and 75 males and 33 females with a mean age of 11±2.0 in the control group. 32 (29.6%) autistic cases showed null genotypes for GSTT1 and 21(19.4%) autistic children showed null genotypes for GSTM1. 3 (2.85%) control children showed a null genotype for GSTT1 and 5 (4.6%) control children showed a null genotype for GSTM1. The GSTT1 and GSTM1 null genotypes were observed to be significantly associated with the risk of autism (p value-0.0001, OR-14.73, 95% CI 4.35-49.90) and (p value-0.003, OR-4.731, 95% CI 1.71-13.08) respectively. The findings of our study suggested that GSTT1 and GSTM1 null genotype is one of the potential risk factors for autism through oxidative stress mechanism in our population. None
氧化应激是机体活性氧(ROS)产生与抗氧化防御能力之间的失衡。长期氧化应激有助于细胞衰老，并在多种疾病的发病机制中发挥作用。一些研究表明，氧化应激在ASD的发病机制中起作用。本研究旨在记录GSTTT1和GSTM1零基因型在印度自闭症人群中的关联。研究人员从108名自闭症儿童和年龄匹配的健康对照组中分离出基因组DNA。分析分离基因组DNA的质量和数量。采用聚合酶链反应分析GSTT1和GSTM1零基因型，内阳性对照。采用SPSS 15.0进行统计学分析。本研究纳入男性85例，女性23例，平均年龄11.7±3.5岁;对照组男性75例，女性33例，平均年龄11±2.0岁。32例(29.6%)自闭症患儿GSTT1基因型为零，21例(19.4%)自闭症患儿GSTM1基因型为零。3例(2.85%)对照儿童GSTT1基因型为零，5例(4.6%)对照儿童GSTM1基因型为零。GSTT1和GSTM1零基因型分别与自闭症风险显著相关(p值0.0001,OR-14.73, 95% CI 4.35 ~ 49.90)和(p值0.003,OR-4.731, 95% CI 1.71 ~ 13.08)。本研究结果提示GSTT1和GSTM1零基因型通过氧化应激机制是我国人群自闭症的潜在危险因素之一。没有一个
{"title":"Glutathione S Transferase Theta1 and Mu1 (GSTT1 and GSTM1 ) deletion among autistic population of India","authors":"Rajat Hegde, P. Gai, Smita Hegde, S. Kulkarni, Kusal K. Das","doi":"10.2174/2666082219666230302142608","DOIUrl":"https://doi.org/10.2174/2666082219666230302142608","url":null,"abstract":"\u0000\u0000Oxidative stress is an imbalance between an organism's reactive oxygen species [ROS] production and antioxidant defence capacity. Long-term oxidative stress contributes to cellular ageing and plays a role in the pathogenesis of several diseases. Several investigations indicated that oxidative stress has a role in the pathogenesis of ASD.\u0000\u0000\u0000\u0000Present study was undertaken to record the association of GSTTT1 and GSTM1 null genotype among the autistic population of India.\u0000\u0000\u0000\u0000Genomic DNA was isolated from 108 autistic children along with healthy age-matched control. The quality and quantity of the isolated genomic DNA were analysed. GSTT1 and GSTM1 null genotype was analysed using polymerase chain reaction with internal positive control. Statistical analysis was performed using SPSS 15.0.\u0000\u0000\u0000\u0000Present study included 85 males and 23 females with a mean age of 11.7±3.5 and 75 males and 33 females with a mean age of 11±2.0 in the control group. 32 (29.6%) autistic cases showed null genotypes for GSTT1 and 21(19.4%) autistic children showed null genotypes for GSTM1. 3 (2.85%) control children showed a null genotype for GSTT1 and 5 (4.6%) control children showed a null genotype for GSTM1. The GSTT1 and GSTM1 null genotypes were observed to be significantly associated with the risk of autism (p value-0.0001, OR-14.73, 95% CI 4.35-49.90) and (p value-0.003, OR-4.731, 95% CI 1.71-13.08) respectively.\u0000\u0000\u0000\u0000The findings of our study suggested that GSTT1 and GSTM1 null genotype is one of the potential risk factors for autism through oxidative stress mechanism in our population.\u0000\u0000\u0000\u0000None\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41984551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.2174/266608221901230124145026
Domenico De Berardis
{"title":"Meet the Section Editor","authors":"Domenico De Berardis","doi":"10.2174/266608221901230124145026","DOIUrl":"https://doi.org/10.2174/266608221901230124145026","url":null,"abstract":"","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136173521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.2174/266608221901230124143557
R. Badgaiyan
{"title":"Preface","authors":"R. Badgaiyan","doi":"10.2174/266608221901230124143557","DOIUrl":"https://doi.org/10.2174/266608221901230124143557","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43192958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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