Pub Date : 2023-07-21DOI: 10.22328/2077-9828-2023-15-2-114-118
T. M. Cherkasova, A. B. Kazanina, N. Gurevich, E. Kravtsova, V. M. Moskvina
In the modern world, the problem of simultaneous infection with syphilis and HIV infection is of particular relevance. The same conditions and transmission routes, identical contingents at risk of infection, make it possible to assume the presence of coinfection with a high degree of probability. It should be noted that in an HIV-infected pregnant woman, against the background of receiving antiretroviral therapy, the clinical picture of syphilis changes, its diagnosis becomes difficult, and the risk of infection of the newborn increases.
{"title":"Realization of early congenital latent syphilis in a newborn from an HIV-infected mother","authors":"T. M. Cherkasova, A. B. Kazanina, N. Gurevich, E. Kravtsova, V. M. Moskvina","doi":"10.22328/2077-9828-2023-15-2-114-118","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-114-118","url":null,"abstract":"In the modern world, the problem of simultaneous infection with syphilis and HIV infection is of particular relevance. The same conditions and transmission routes, identical contingents at risk of infection, make it possible to assume the presence of coinfection with a high degree of probability. It should be noted that in an HIV-infected pregnant woman, against the background of receiving antiretroviral therapy, the clinical picture of syphilis changes, its diagnosis becomes difficult, and the risk of infection of the newborn increases.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45022476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.22328/2077-9828-2023-15-2-100-105
A. Khryanin, D. V. Kapustin, A. P. Nadeev, V. Sturov, E. V. Pushkarev
An important role in a number of different clinical manifestations of HIV infection is played by the pathology of the skin and mucous membranes. Kaposi sarcoma (KS) is a multifocal malignant tumor of vascular origin with a predominant lesion of the skin and involvement of internal organs. Prior to the development of the HIV epidemic, KS was considered a rare tumor. Under conditions of increasing immunosuppression, HIV-associated KS tends to have a more severe course, generalization, and is accompanied by damage to visceral organs, leading to the death of patients. The authors demonstrate a clinical case of generalized KS with lesions of the skin, mucous membranes and internal organs (lungs) in a patient with HIV infection. The pulmonary form of KS is rare, but often leads to death.
{"title":"Generalized HIV-associated kaposi's sarcoma with multiorgan lesion in a comorbid patient","authors":"A. Khryanin, D. V. Kapustin, A. P. Nadeev, V. Sturov, E. V. Pushkarev","doi":"10.22328/2077-9828-2023-15-2-100-105","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-100-105","url":null,"abstract":"An important role in a number of different clinical manifestations of HIV infection is played by the pathology of the skin and mucous membranes. Kaposi sarcoma (KS) is a multifocal malignant tumor of vascular origin with a predominant lesion of the skin and involvement of internal organs. Prior to the development of the HIV epidemic, KS was considered a rare tumor. Under conditions of increasing immunosuppression, HIV-associated KS tends to have a more severe course, generalization, and is accompanied by damage to visceral organs, leading to the death of patients. The authors demonstrate a clinical case of generalized KS with lesions of the skin, mucous membranes and internal organs (lungs) in a patient with HIV infection. The pulmonary form of KS is rare, but often leads to death.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46820459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.22328/2077-9828-2023-15-2-69-80
Z. Zagdyn, N. V. Kobesov, E. V. Verbitskaya, V. L. Denuyshenkov
Objective. Evaluation of the global HIV burden in Russia, identification of progress made and outstanding problems for 1987–2021.Materials and methods. The analysis of national and foreign publications, data obtained from Rosstat, from forms of federal statistical observation and the FNM of the AIDS Center of Rospotrebnadzor was carried out. The study used information-analytical, epidemiological and statistical methods. Mathematical calculations were performed using the SPSS-26 program.Results and discussion. In Russia, the target indicators of the state program of HIV/AIDS response strategy is being provided in different directions: the greatest success has been achieved in conducting chemoprevention of mother to child HIV transmission, somewhat less in the coverage of the population with HIV testing, which amounted to 26.1% versus the target indicator of 30.0% in 2021, the number of newly detected cases of HIV infection is decreasing (from 73.7 to 71.0 thousand people in 2020–2021, versus the target indicators of 76.1 and 72.3 thousand people, respectively), there is decreasing the HIV incidence (40.4 per 100 thousand. in 2021 versus 68.5 in 2015). Antiretroviral therapy (ART) coverage of patients registered in AIDS Centers went up from 12.4% to 78.9% in 2007–2021. Meanwhile, the determining factor in the HIV/AIDS epidemic progress in Russia is a heterosexual route (F=75.1, p<0.0001) leading to the penetration of infection into all population segments. In addition, despite the increase in the coverage of ART for people living with HIV (PLWH), the HIV mortality rate is remaining high (11.6 per 100 thousand population in 2021, versus 7.9 in 2007).Conclusion. In recent years, there has been a positive trend in the coverage of three-stage HIV chemoprophylaxis in pregnant women, women in labor and newborns. The number of HIV population based screening tests is increasing annually. There is an increase in the ART coverage of patients and a decrease in the number of newly diagnosed cases of the disease. However, along with the observed increase in the HIV spread through heterosexual contacts, it is necessary to strengthen information and preventive measures, especially among the reproductive age group. The high HIV mortality rate is continuing to remain, despite the increase in ART coverage of PLWH. The identified problems need to be solved comprehensively based on the results of large-scale sociological research conducted in various regions of Russia.
{"title":"The global burden of HIV/AIDS in Russia in terms of public health. Part 1","authors":"Z. Zagdyn, N. V. Kobesov, E. V. Verbitskaya, V. L. Denuyshenkov","doi":"10.22328/2077-9828-2023-15-2-69-80","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-69-80","url":null,"abstract":"Objective. Evaluation of the global HIV burden in Russia, identification of progress made and outstanding problems for 1987–2021.Materials and methods. The analysis of national and foreign publications, data obtained from Rosstat, from forms of federal statistical observation and the FNM of the AIDS Center of Rospotrebnadzor was carried out. The study used information-analytical, epidemiological and statistical methods. Mathematical calculations were performed using the SPSS-26 program.Results and discussion. In Russia, the target indicators of the state program of HIV/AIDS response strategy is being provided in different directions: the greatest success has been achieved in conducting chemoprevention of mother to child HIV transmission, somewhat less in the coverage of the population with HIV testing, which amounted to 26.1% versus the target indicator of 30.0% in 2021, the number of newly detected cases of HIV infection is decreasing (from 73.7 to 71.0 thousand people in 2020–2021, versus the target indicators of 76.1 and 72.3 thousand people, respectively), there is decreasing the HIV incidence (40.4 per 100 thousand. in 2021 versus 68.5 in 2015). Antiretroviral therapy (ART) coverage of patients registered in AIDS Centers went up from 12.4% to 78.9% in 2007–2021. Meanwhile, the determining factor in the HIV/AIDS epidemic progress in Russia is a heterosexual route (F=75.1, p<0.0001) leading to the penetration of infection into all population segments. In addition, despite the increase in the coverage of ART for people living with HIV (PLWH), the HIV mortality rate is remaining high (11.6 per 100 thousand population in 2021, versus 7.9 in 2007).Conclusion. In recent years, there has been a positive trend in the coverage of three-stage HIV chemoprophylaxis in pregnant women, women in labor and newborns. The number of HIV population based screening tests is increasing annually. There is an increase in the ART coverage of patients and a decrease in the number of newly diagnosed cases of the disease. However, along with the observed increase in the HIV spread through heterosexual contacts, it is necessary to strengthen information and preventive measures, especially among the reproductive age group. The high HIV mortality rate is continuing to remain, despite the increase in ART coverage of PLWH. The identified problems need to be solved comprehensively based on the results of large-scale sociological research conducted in various regions of Russia.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42978717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.22328/2077-9828-2023-15-2-59-68
P. Safonova, O. Koltsova
Objective. To assess ART adherence and treatment continuity in young adults living with HIV since birth or childhood in the first years after transition from paediatric to adult service of the AIDS Center, as well as to analyse factors associated with treatment adherence interruption after transition to adult care.Materials and methods. In our study, 86 cases of young people living with HIV since birth or childhood were obtained by chart audit and analyzed, among whom 53.5% were girls and 64.0% lived at home at the time of their 18th birthday, who have been transferred from paediatric to adult care of the AIDS Center for more than one year.Results and discussion. The majority (92%) of young adults living with HIV since birth or childhood retained in the health care system in the first year after the transition, but only 53–62% were highly adherent to treatment and monitoring for HIV infection in the first years after the transition. Episodes of non-adherence to treatment during childhood and adolescence, «more complex» ART scheme and the lack of adult’s social support at the time of 18th birthday increase the likelihood of interruption in treatment adherence in the first year after transition to adult care, while the combination of these factors has negative consequences for adherence and continuity of treatment for a longer period of time.Conclusion. Successful transition from paediatric to adult care for patients living with HIV since birth or childhood requires special additional attention of the health care system, contributes to the health protection of each patient, aims to stop HIV in the second generation.
{"title":"Adherence to treatment in young people with perinatal HIV infection in the first years after transition from pediatric to the adult medical service","authors":"P. Safonova, O. Koltsova","doi":"10.22328/2077-9828-2023-15-2-59-68","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-59-68","url":null,"abstract":"Objective. To assess ART adherence and treatment continuity in young adults living with HIV since birth or childhood in the first years after transition from paediatric to adult service of the AIDS Center, as well as to analyse factors associated with treatment adherence interruption after transition to adult care.Materials and methods. In our study, 86 cases of young people living with HIV since birth or childhood were obtained by chart audit and analyzed, among whom 53.5% were girls and 64.0% lived at home at the time of their 18th birthday, who have been transferred from paediatric to adult care of the AIDS Center for more than one year.Results and discussion. The majority (92%) of young adults living with HIV since birth or childhood retained in the health care system in the first year after the transition, but only 53–62% were highly adherent to treatment and monitoring for HIV infection in the first years after the transition. Episodes of non-adherence to treatment during childhood and adolescence, «more complex» ART scheme and the lack of adult’s social support at the time of 18th birthday increase the likelihood of interruption in treatment adherence in the first year after transition to adult care, while the combination of these factors has negative consequences for adherence and continuity of treatment for a longer period of time.Conclusion. Successful transition from paediatric to adult care for patients living with HIV since birth or childhood requires special additional attention of the health care system, contributes to the health protection of each patient, aims to stop HIV in the second generation.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47962249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.22328/2077-9828-2023-15-2-81-89
A. A. Savina, A. S. Lukmanov, E. Zemlyanova
Background. In the beginning of 2000s infectious mortality in Russian regions was predominantly determined by socially significant diseases i.e. TB, hepatitis and HIV. Over 20-year period contribution of HIV to mortality within the class «Certain infectious and parasitic diseases» increased multi-fold and it moved to the top of ranking. According to experts’ opinion, accelerated increase of mortality from HIV in the second decade of XXI century was partly conditioned by peculiarities of registration of death causes as well as insufficient antiretroviral coverage in Russian regions.Objective. Identification of trends and features of the dynamics of mortality from HIV/AIDS in certain age groups in the subjects of the Russian Federation.Materials and methods. Analysis of mortality indicators in Russian regions was conducted using official statistics of Rosstat and Federal Service for Surveillance in Healthcare for 2000–2021. Method of direct ranking was applied to analyze mortality from HIV-associated causes.Results and discussion. According to official statistics, mortality from HIV-associated causes has reached its peak values in 2018. Analysis of gender differences shows that mortality in males is twice higher than in females. There are substantial differences in regional levels of mortality from HIV-associated causes. The highest mortality levels from those causes were registered in several regions of Siberia and Urals.Conclusion. The study results show that Kemerovo region is the most unfavourable in terms of HIV-mortality. In 2021, the indicator estimated 50.4 per 100,000 that is nearly 5-fold higher than the country’s average. The number of HIV deaths in Kemerovo region was higher than cumulative number of deaths from external causes (alcohol poisonings, suicides, homicides, drownings and transport injuries). High levels of mortality from HIV were also registered in Perm territory (32.3), Irkutsk (32.2), Novosibirsk (27.5) and Sverdlovsk (26.4) regions.
{"title":"HIV-mortality trends in the regions of Russian Federation","authors":"A. A. Savina, A. S. Lukmanov, E. Zemlyanova","doi":"10.22328/2077-9828-2023-15-2-81-89","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-81-89","url":null,"abstract":"Background. In the beginning of 2000s infectious mortality in Russian regions was predominantly determined by socially significant diseases i.e. TB, hepatitis and HIV. Over 20-year period contribution of HIV to mortality within the class «Certain infectious and parasitic diseases» increased multi-fold and it moved to the top of ranking. According to experts’ opinion, accelerated increase of mortality from HIV in the second decade of XXI century was partly conditioned by peculiarities of registration of death causes as well as insufficient antiretroviral coverage in Russian regions.Objective. Identification of trends and features of the dynamics of mortality from HIV/AIDS in certain age groups in the subjects of the Russian Federation.Materials and methods. Analysis of mortality indicators in Russian regions was conducted using official statistics of Rosstat and Federal Service for Surveillance in Healthcare for 2000–2021. Method of direct ranking was applied to analyze mortality from HIV-associated causes.Results and discussion. According to official statistics, mortality from HIV-associated causes has reached its peak values in 2018. Analysis of gender differences shows that mortality in males is twice higher than in females. There are substantial differences in regional levels of mortality from HIV-associated causes. The highest mortality levels from those causes were registered in several regions of Siberia and Urals.Conclusion. The study results show that Kemerovo region is the most unfavourable in terms of HIV-mortality. In 2021, the indicator estimated 50.4 per 100,000 that is nearly 5-fold higher than the country’s average. The number of HIV deaths in Kemerovo region was higher than cumulative number of deaths from external causes (alcohol poisonings, suicides, homicides, drownings and transport injuries). High levels of mortality from HIV were also registered in Perm territory (32.3), Irkutsk (32.2), Novosibirsk (27.5) and Sverdlovsk (26.4) regions.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68331222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.22328/2077-9828-2023-15-2-106-113
M. A. Savchenko, N. Voinov, D. Sitovskaya, O. M. Vorobieva, Y. Zabrodskaya, R. Grozov, A. Panteleev
Aim of the study. To present a clinical observation of a combined brain tissue lesion in a patient with HIV infection, which emphasizes the complexity of the differential diagnosis process when making a final diagnosis, the need for interdisciplinary interaction of trained specialists.Materials and methods. The description of clinical observation, results of instrumental diagnostic methods is performed. The data of histological and immunohistochemical examination of the biopsy of the patient’s brain tissue are presented.Results and conclusion. Damage to the central nervous system in patients with HIV infection is characterized by a wide range of etiological factors. Diagnosis, in this case, is a complex task and requires a comprehensive examination of the patient, including performing computed tomography, magnetic resonance imaging of the brain, as well as cultural and molecular genetic methods of studying cerebrospinal fluid. Pathognomonic clinical manifestations and neuroradiological syndromes do not exist, and several pathogens can be released simultaneously in the biological fluids of the patient. In addition to determining the etiology of the infectious process, it is necessary to exclude a brain tumor lesion with possible biopsy, histological and immunohistochemical verification of the neoplasm.
{"title":"Combination of primary CNS lymphoma and mycobacteriosis of the brain in the background of HIV infection","authors":"M. A. Savchenko, N. Voinov, D. Sitovskaya, O. M. Vorobieva, Y. Zabrodskaya, R. Grozov, A. Panteleev","doi":"10.22328/2077-9828-2023-15-2-106-113","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-106-113","url":null,"abstract":"Aim of the study. To present a clinical observation of a combined brain tissue lesion in a patient with HIV infection, which emphasizes the complexity of the differential diagnosis process when making a final diagnosis, the need for interdisciplinary interaction of trained specialists.Materials and methods. The description of clinical observation, results of instrumental diagnostic methods is performed. The data of histological and immunohistochemical examination of the biopsy of the patient’s brain tissue are presented.Results and conclusion. Damage to the central nervous system in patients with HIV infection is characterized by a wide range of etiological factors. Diagnosis, in this case, is a complex task and requires a comprehensive examination of the patient, including performing computed tomography, magnetic resonance imaging of the brain, as well as cultural and molecular genetic methods of studying cerebrospinal fluid. Pathognomonic clinical manifestations and neuroradiological syndromes do not exist, and several pathogens can be released simultaneously in the biological fluids of the patient. In addition to determining the etiology of the infectious process, it is necessary to exclude a brain tumor lesion with possible biopsy, histological and immunohistochemical verification of the neoplasm.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44409906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.22328/2077-9828-2023-15-2-90-99
E. Tsybikova, I. Lapshina
Objective: to study the dynamics of mortality from tuberculosis and HIV infection, as well as the causes of death of contingents with tuberculosis and HIV infection, in Russia and the subjects of the Russian Federation, in the period before and during the COVID-19 pandemic.Materials and methods. Rosstat data for 2002–2021 were used to analyze mortality from tuberculosis, HIV infection, infectious diseases and COVID-19 in Russia. Information on the number and causes of death of contingents with tuberculosis and HIV infection was obtained from Federal statistical observation Forms No. 61, No. 8 and No. 33 for 2012–2021. Information on the causes of death of contingents with tuberculosis, including from COVID-19, was received upon request from 16 subjects of the Russian Federation. Statistical analysis was carried out using the program Stat Tech v.2.8.8 (developed by Stattech LLC, Russia).Results and discussion. In Russia, during the pandemic (2020–2021), there was a synchronous decrease in mortality from infectious diseases, tuberculosis and HIV infection. At the same time, a «reverse transition» was registered in the dynamics of these indicators, as a result of which the rates of reduction in mortality from HIV infection exceeded those from tuberculosis for the first time in the last 20 years.The main factor that had a positive impact on the dynamics of mortality from HIV infection was an increase in the coverage of HIV-infected patients with antiretroviral therapy, the share of which increased to 82.2% and 83.3% in 2020–2021 (2019 — 71%). The deterioration of the epidemic situation of tuberculosis during the pandemic was due to the introduction of restrictive measures (lockdown), which led to a decrease in the proportion of the population covered by screening aimed at early detection of tuberculosis among the population. As a result, in the structure of the deceased contingents with tuberculosis, the proportion of those whose cause of death was tuberculosis increased to 30% (ICD-10 A15–A19).Such dynamics was due to an increase to 7.6% in the proportion of patients diagnosed with tuberculosis posthumously (in 2019 — 4.8%). In addition, among the deceased contingents with tuberculosis, every 3rd was a patient with tuberculosis combined with HIV infection. During the pandemic, in 16 regions of the Russian Federation, the proportion of deaths from COVID-19 was low and amounted to only 2.3% in the structure of deceased contingents with tuberculosis.Conclusion. During the pandemic (2020–2021) in Russia, there was a slowdown in the rate of decline in mortality from tuberculosis, due to an increase in the proportion of patients in whom tuberculosis was detected late as a result of post-mortem diagnosis. Maintaining a high proportion of patients with tuberculosis combined with HIV infection in the structure of deceased populations with tuberculosis slows down the rate of reduction in mortality from HIV infection.
{"title":"Mortality from tuberculosis and HIV infection in Russia in the period before and during the COVID-19 pandemic","authors":"E. Tsybikova, I. Lapshina","doi":"10.22328/2077-9828-2023-15-2-90-99","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-90-99","url":null,"abstract":"Objective: to study the dynamics of mortality from tuberculosis and HIV infection, as well as the causes of death of contingents with tuberculosis and HIV infection, in Russia and the subjects of the Russian Federation, in the period before and during the COVID-19 pandemic.Materials and methods. Rosstat data for 2002–2021 were used to analyze mortality from tuberculosis, HIV infection, infectious diseases and COVID-19 in Russia. Information on the number and causes of death of contingents with tuberculosis and HIV infection was obtained from Federal statistical observation Forms No. 61, No. 8 and No. 33 for 2012–2021. Information on the causes of death of contingents with tuberculosis, including from COVID-19, was received upon request from 16 subjects of the Russian Federation. Statistical analysis was carried out using the program Stat Tech v.2.8.8 (developed by Stattech LLC, Russia).Results and discussion. In Russia, during the pandemic (2020–2021), there was a synchronous decrease in mortality from infectious diseases, tuberculosis and HIV infection. At the same time, a «reverse transition» was registered in the dynamics of these indicators, as a result of which the rates of reduction in mortality from HIV infection exceeded those from tuberculosis for the first time in the last 20 years.The main factor that had a positive impact on the dynamics of mortality from HIV infection was an increase in the coverage of HIV-infected patients with antiretroviral therapy, the share of which increased to 82.2% and 83.3% in 2020–2021 (2019 — 71%). The deterioration of the epidemic situation of tuberculosis during the pandemic was due to the introduction of restrictive measures (lockdown), which led to a decrease in the proportion of the population covered by screening aimed at early detection of tuberculosis among the population. As a result, in the structure of the deceased contingents with tuberculosis, the proportion of those whose cause of death was tuberculosis increased to 30% (ICD-10 A15–A19).Such dynamics was due to an increase to 7.6% in the proportion of patients diagnosed with tuberculosis posthumously (in 2019 — 4.8%). In addition, among the deceased contingents with tuberculosis, every 3rd was a patient with tuberculosis combined with HIV infection. During the pandemic, in 16 regions of the Russian Federation, the proportion of deaths from COVID-19 was low and amounted to only 2.3% in the structure of deceased contingents with tuberculosis.Conclusion. During the pandemic (2020–2021) in Russia, there was a slowdown in the rate of decline in mortality from tuberculosis, due to an increase in the proportion of patients in whom tuberculosis was detected late as a result of post-mortem diagnosis. Maintaining a high proportion of patients with tuberculosis combined with HIV infection in the structure of deceased populations with tuberculosis slows down the rate of reduction in mortality from HIV infection.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44646796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-20DOI: 10.22328/2077-9828-2023-15-2-19-36
G. N. Khokhlova, O. Koltsova, E. Isaeva, E. Boeva, V. Rassokhin
Many infectious diseases still have medical and social significance, the late detection and untimely treatment of which causes persistent health disorders, leading to early disability. Drug therapy has significantly reduced mortality among people on the background or after infections, increasing the duration and quality of life. However, lesions of the nervous system in human immunodeficiency virus (HIV), viral hepatitis, new coronavirus and other infections, and related neurocognitive disorders cause great concern, are accompanied by complex and clinically important problems.The authors conducted an analytical review of publications and their own research based on the experience of implementing cognitive training in neurocognitive rehabilitation programs that have proven their effectiveness for patients with cognitive disorders against the background of socially significant infections and comorbid conditions.
{"title":"Cognitive training as a technology for protecting and restoring the functions of the central nervous system in patients with infectious pathology","authors":"G. N. Khokhlova, O. Koltsova, E. Isaeva, E. Boeva, V. Rassokhin","doi":"10.22328/2077-9828-2023-15-2-19-36","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-19-36","url":null,"abstract":"Many infectious diseases still have medical and social significance, the late detection and untimely treatment of which causes persistent health disorders, leading to early disability. Drug therapy has significantly reduced mortality among people on the background or after infections, increasing the duration and quality of life. However, lesions of the nervous system in human immunodeficiency virus (HIV), viral hepatitis, new coronavirus and other infections, and related neurocognitive disorders cause great concern, are accompanied by complex and clinically important problems.The authors conducted an analytical review of publications and their own research based on the experience of implementing cognitive training in neurocognitive rehabilitation programs that have proven their effectiveness for patients with cognitive disorders against the background of socially significant infections and comorbid conditions.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42466180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-20DOI: 10.22328/2077-9828-2023-15-2-37-47
H. Huynh, D. Valutite, A. N. Schemelev, V. S. Davydenko, Y. Ostankova, T. Truong, T. Tran, T. Nguyen, A. Semenov
Background. In Vietnam, there has been an increase in efforts to monitor and prevent mother-to-child transmission of HIV since 2013. However, data on HIV drug resistance among HIV-1 infected children younger than 18 months of age remain limited. The study fills a critical knowledge gap by providing important insights into the prevalence of resistance among this population in the Southern and Central Highland provinces of Vietnam.Objective. This study aimed to determine the prevalence of HIV drug resistance and patterns of mutation among treatment-naïve children under the age of 18 months who had been recently diagnosed with HIV.Material and methods. Between May 2017 and May 2021, stored remnant DBS samples were collected from children under the age of 18 months who had been diagnosed with HIV through routine Early Infant Diagnosis testing in Central Highland and Southern Vietnam. HIV drug resistance tests were performed, and interpretation was done using the Stanford algorithm.Results and discussion. Overall, 111 samples with eligible viremia for sequencing (ct value <31) were collected for genotyping, in which 110 protease sequences and 106 complete reverse transcriptase regions were generated. Males were 61.3%, 52.3% were aged from 6 weeks to <9 months and 37.0% were breastfed. Access to mother-to-child intervention was reported in 60.3%. The accumulation of major drug resistance mutations was found in 43.8% of infants and most of them were resistant to Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI) (37.7%). High-level resistance to Nevirapine was present in 40% of cases. The risk factors associated with NNRTI resistance were antiretroviral prophylaxis (aOR: 3.68, 95% CI: 1.83–7.45) and breast-feeding history (aOR: 2.16, 95% CI: 1.03–4.53). CRF01-AE was the predominant subtype.Conclusion. The study identified a high prevalence of resistance to NNRTIs among HIV-1 infected infants less than 18 months of age in the Southern and Central Highland provinces of Vietnam. This highlights the need for further investigation and a potentially larger national survey to confirm the extent of this issue in Vietnam. Our findings support the current actions of the Vietnam Ministry of Health, which prioritize integrase inhibitor-based regimens as the preferred first line of ART for children to achieve durable viral suppression and minimize treatment failure. This approach aligns with the recommendations of the World Health Organization.
{"title":"Prevalence of HIV-1 drug resistance among early diagnosed HIV-infected children enrolled through the national program for prevention of mother-to-child transmission in Southern and Central Highland provinces — Vietnam within 2017–2021","authors":"H. Huynh, D. Valutite, A. N. Schemelev, V. S. Davydenko, Y. Ostankova, T. Truong, T. Tran, T. Nguyen, A. Semenov","doi":"10.22328/2077-9828-2023-15-2-37-47","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-37-47","url":null,"abstract":"Background. In Vietnam, there has been an increase in efforts to monitor and prevent mother-to-child transmission of HIV since 2013. However, data on HIV drug resistance among HIV-1 infected children younger than 18 months of age remain limited. The study fills a critical knowledge gap by providing important insights into the prevalence of resistance among this population in the Southern and Central Highland provinces of Vietnam.Objective. This study aimed to determine the prevalence of HIV drug resistance and patterns of mutation among treatment-naïve children under the age of 18 months who had been recently diagnosed with HIV.Material and methods. Between May 2017 and May 2021, stored remnant DBS samples were collected from children under the age of 18 months who had been diagnosed with HIV through routine Early Infant Diagnosis testing in Central Highland and Southern Vietnam. HIV drug resistance tests were performed, and interpretation was done using the Stanford algorithm.Results and discussion. Overall, 111 samples with eligible viremia for sequencing (ct value <31) were collected for genotyping, in which 110 protease sequences and 106 complete reverse transcriptase regions were generated. Males were 61.3%, 52.3% were aged from 6 weeks to <9 months and 37.0% were breastfed. Access to mother-to-child intervention was reported in 60.3%. The accumulation of major drug resistance mutations was found in 43.8% of infants and most of them were resistant to Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI) (37.7%). High-level resistance to Nevirapine was present in 40% of cases. The risk factors associated with NNRTI resistance were antiretroviral prophylaxis (aOR: 3.68, 95% CI: 1.83–7.45) and breast-feeding history (aOR: 2.16, 95% CI: 1.03–4.53). CRF01-AE was the predominant subtype.Conclusion. The study identified a high prevalence of resistance to NNRTIs among HIV-1 infected infants less than 18 months of age in the Southern and Central Highland provinces of Vietnam. This highlights the need for further investigation and a potentially larger national survey to confirm the extent of this issue in Vietnam. Our findings support the current actions of the Vietnam Ministry of Health, which prioritize integrase inhibitor-based regimens as the preferred first line of ART for children to achieve durable viral suppression and minimize treatment failure. This approach aligns with the recommendations of the World Health Organization.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46283811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-20DOI: 10.22328/2077-9828-2023-15-2-48-58
T. Balde, A. Shchemelev, Y. Ostankova, S. Boumbaly, D. Valutite, V. S. Davydenko, E. Serikova, E. B. Zueva, E. Anufrieva, V. V. Skvoroda, D. A. Vasileva, E. Esaulenko, A. Semenov, A. Totolian
The aim of this study was to assess the prevalence and study of the molecular genetic characteristics of the human immunodeficiency virus in pregnant women of the Republic of Guinea.Materials and methods. The material for the study was blood plasma samples of 972 pregnant women from the Republic of Guinea. The patients were examined for the presence of HIV infection serological (Ag+Ab) and molecular markers (RNA). For patients with a positive PCR result and a sufficient viral load (>500 c/ml), the genetic sequences of the pol gene fragment responsible for the synthesis of pro and rev proteins were obtained by Sanger sequencing. These sequences were used for phylogenetic analysis and examined for drug resistance mutations.Results and discussion. 12.96% of patients was positive in ELISA. Among women who were positive in ELISA, RNA was detected in 76.98% of cases, however, in 11 cases, RNA was detected in patients without serological markers of HIV infection, so the incidence of HIV RNA in the entire surveyed population was 11.11%. In the vast majority of cases, the circulating recombinant form 02_AG is found. Based on the analysis, we assume a significant contribution of recombinant forms of HIV to the genetic diversity of the virus in the region under study.The incidence of DR mutations was quite high (26.80%). The most frequent substitutions were in position 20 of the protease (70.10%, 95% CI 59.96–78.98%), of which the K20I mutation was dominant. In addition, the L10I/V mutation was relatively common, increasing the replication of viruses with other PI resistance mutations. Among the mutations associated with HIV resistance to NNRTIs, a non-polymorphic mutation V179T was found.Conclusion. An important factor influencing the effectiveness of Prevention of Mother to Child Transmission identified in this study was the high prevalence of PDR among pregnant women in Guinea. The high prevalence of drug resistance mutations found in this study in pregnant women, as well as in ART-naive women, indicates that current regimens in Guinea are insufficient to prevent vertical HIV infection.
{"title":"HIV in pregnant women group in the Republic of Guinea: frequency and genetic characteristics","authors":"T. Balde, A. Shchemelev, Y. Ostankova, S. Boumbaly, D. Valutite, V. S. Davydenko, E. Serikova, E. B. Zueva, E. Anufrieva, V. V. Skvoroda, D. A. Vasileva, E. Esaulenko, A. Semenov, A. Totolian","doi":"10.22328/2077-9828-2023-15-2-48-58","DOIUrl":"https://doi.org/10.22328/2077-9828-2023-15-2-48-58","url":null,"abstract":"The aim of this study was to assess the prevalence and study of the molecular genetic characteristics of the human immunodeficiency virus in pregnant women of the Republic of Guinea.Materials and methods. The material for the study was blood plasma samples of 972 pregnant women from the Republic of Guinea. The patients were examined for the presence of HIV infection serological (Ag+Ab) and molecular markers (RNA). For patients with a positive PCR result and a sufficient viral load (>500 c/ml), the genetic sequences of the pol gene fragment responsible for the synthesis of pro and rev proteins were obtained by Sanger sequencing. These sequences were used for phylogenetic analysis and examined for drug resistance mutations.Results and discussion. 12.96% of patients was positive in ELISA. Among women who were positive in ELISA, RNA was detected in 76.98% of cases, however, in 11 cases, RNA was detected in patients without serological markers of HIV infection, so the incidence of HIV RNA in the entire surveyed population was 11.11%. In the vast majority of cases, the circulating recombinant form 02_AG is found. Based on the analysis, we assume a significant contribution of recombinant forms of HIV to the genetic diversity of the virus in the region under study.The incidence of DR mutations was quite high (26.80%). The most frequent substitutions were in position 20 of the protease (70.10%, 95% CI 59.96–78.98%), of which the K20I mutation was dominant. In addition, the L10I/V mutation was relatively common, increasing the replication of viruses with other PI resistance mutations. Among the mutations associated with HIV resistance to NNRTIs, a non-polymorphic mutation V179T was found.Conclusion. An important factor influencing the effectiveness of Prevention of Mother to Child Transmission identified in this study was the high prevalence of PDR among pregnant women in Guinea. The high prevalence of drug resistance mutations found in this study in pregnant women, as well as in ART-naive women, indicates that current regimens in Guinea are insufficient to prevent vertical HIV infection.","PeriodicalId":37381,"journal":{"name":"HIV Infection and Immunosuppressive Disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44520168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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