Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"Influence of sintering protocol and translucency-enhancing liquid on the mechanical performance of anterior zirconia crowns","authors":"Nikolaus Kronwitter,&nbsp;Angelika Rauch,&nbsp;Sebastian Hahnel,&nbsp;Martin Rosentritt","doi":"10.1016/j.jmbbm.2025.107290","DOIUrl":"10.1016/j.jmbbm.2025.107290","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to evaluate the effects of a translucency-enhancing liquid (TEL) and high-speed sintering (HS) on the mechanical behavior, with a focus on the survival rates and fracture forces of anterior zirconia crowns with different yttria contents.</div></div><div><h3>Materials and methods</h3><div>Anterior crowns (16 groups, n = 8 per group) were fabricated using four different zirconia materials (3Y-TZP, 4Y-TZP, 5Y-TZP, and multilayer (ML)). The 3Y and 4Y groups were treated with a TEL in three variations: no treatment (NL), two-layer penetration (2L), and four-layer penetration (4L). The 5Y-TZP and ML zirconia crowns served as reference groups without TEL treatment. All specimens underwent either conventional (CS) or high-speed (HS) sintering before being subjected to thermocyclic and mechanical loading (TCML), followed by a load-to-fracture test. Statistics: ANOVA, Bonferroni test, Shapiro-Wilk test, Pearson correlation; α = 0.05.</div></div><div><h3>Results</h3><div>Three specimens in group 5Y-NL-CS and one in group 4Y-NL-HS failed during TCML. Fracture forces varied significantly between different types of zirconia and decreased with increasing yttria content. While mean fracture forces were not affected by HS or TEL treatment, HS of ML and particularly 5Y-TZP crowns was associated with a higher frequency of crown fractures, indicating material- and condition-specific tendencies of potential clinical relevance.</div></div><div><h3>Conclusion</h3><div>Within the limitations of this in-vitro study - including the use of PMMA abutments, failures during TCML, and material- and failure-specific differences - all specimens withstood forces exceeding the physiological loads expected in the anterior region. Under these conditions, TEL treatment and HS of 3Y-TZP and 4Y-TZP zirconia appear to allow the rapid fabrication of anterior crowns while maintaining their mechanical performance. As optical parameters were not assessed, any potential aesthetic implications of TEL or HS cannot be inferred.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107290"},"PeriodicalIF":3.5,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrosion-fatigue of additively manufactured Ti6Al4V","authors":"William W. Hogg,&nbsp;Mueed Jamal,&nbsp;Nathaniel W. Zuckschwerdt,&nbsp;Cohen M. Hess,&nbsp;Susmita Bose,&nbsp;Amit Bandyopadhyay","doi":"10.1016/j.jmbbm.2025.107289","DOIUrl":"10.1016/j.jmbbm.2025.107289","url":null,"abstract":"<div><div>Additive manufacturing (AM) has been used to process complex one-of-a-kind patient-specific implants, along with on-demand manufacturing with innovative geometries. AM parts are more susceptible to fatigue failure due to inherent porosities than conventionally processed parts. This study investigates the high-cycle rotating bending fatigue behavior of laser powder bed fusion (LPBF) processed Ti6Al4V parts in as-processed and hot isostatically pressed (HIPed) conditions, and compares them to commercially available wrought Ti6Al4V. Ti6Al4V is widely used in orthopedic and dental implants due to its high strength-to-weight ratio, good biocompatibility, and excellent corrosion resistance. To understand the fatigue performance of Ti6Al4V parts, a custom cell was designed to fully immerse the fatigue samples in Dulbecco's Modified Eagle Medium (DMEM) for the duration of the test. The fatigue strength was normalized to the compressive yield strength, and it was found that as-processed samples had the greatest compressive strength but approximately half the relative endurance limit (10⁷ cycles) when compared to wrought and HIPed samples. This inferior fatigue performance of as-processed samples was attributed to porosity defects inherent to the AMed parts. However, it was found through fractography and energy-dispersive spectroscopy (EDS) analyses that these internal defects dominated the fatigue crack initiation in as-processed samples, making DMEM immersion have a minimal effect. The wrought and HIPed samples were susceptible to corrosion fatigue, showing a reduction in endurance limit of 9 % and 6 % in relative strength, respectively. This study highlights the need for <em>in situ</em> corrosion fatigue evaluation of additively manufactured load-bearing implants.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107289"},"PeriodicalIF":3.5,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A computational study of forward head posture biomechanics","authors":"Katterine N. Rios-Peralta ,&nbsp;Afonso J.C. Silva ,&nbsp;Ricardo J. Alves-de-Sousa ,&nbsp;Kathleen M. Curran ,&nbsp;David B. MacManus","doi":"10.1016/j.jmbbm.2025.107288","DOIUrl":"10.1016/j.jmbbm.2025.107288","url":null,"abstract":"<div><div>Forward head posture (FHP) is a common postural deviation linked to musculoskeletal disorders and altered cervical spine biomechanics. This study used a validated finite element model (C0–T1, THUMS v4.2) to quantify the biomechanical effects of FHP, with validation against cadaveric data for sagittal balance and range of motion in flexion–extension, axial rotation, and lateral bending. Sagittal balance parameters, including craniovertebral angle (CVA), occipital protuberance to C2 (OP–C2), cervical lordosis (C1–C2 and C2–C7), greater occipital nerve (GON), and C2 nerve root (C2–NR), were measured before and after a 2.5 cm anterior head displacement. FHP increased upper cervical lordosis and decreased lower cervical curvature, accompanied by measurable narrowing of neural foraminal spaces (GON and C2–NR) and elevated cortical bone stresses, particularly between C2–C3. These changes reflect compensatory adaptations that may predispose to pain and degeneration, underscoring the need for early intervention strategies to mitigate long-term spinal health impacts.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107288"},"PeriodicalIF":3.5,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbubble-based indirect measurement of cell loading in hydrogel bioinks during handling of 3D models","authors":"Swaprakash Yogeshwaran ,&nbsp;Leila Donyaparastlivari ,&nbsp;Ayda Pormoustafa ,&nbsp;Vidhi Patel ,&nbsp;Alexander Buffone ,&nbsp;Rajarshi Chattaraj ,&nbsp;Amir K. Miri","doi":"10.1016/j.jmbbm.2025.107286","DOIUrl":"10.1016/j.jmbbm.2025.107286","url":null,"abstract":"<div><div>We present an inverse-engineering method for estimating physical forces within cell suspensions in 3D scaffolds during fabrication using fluorescent, lipid-coated microbubbles (MBs) filled with an inert fluorocarbon gas. MBs deform and rupture under significant mechanical pressure. In this work, we applied the compressibility characteristics of the MBs to estimate the forces acting on a cell-laden model during fabrication and handling. MBs were encapsulated in hydrogels and subjected to hydrostatic pressure for a specific period, and we demonstrated how calibration curves are generated to estimate the pressure around each MB. We further studied MB response via conventional ultrasound imaging and theoretical modeling. This work demonstrates a simple, scalable approach for estimating physical loads that biological cells experience during extrusion, injection, and other biofabrication processes.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107286"},"PeriodicalIF":3.5,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TBI-induced vessel softening increases brain susceptibility to injury with repeated head trauma","authors":"Farshid Shojaeianforoud ,&nbsp;Alexander M. Venezie ,&nbsp;Jose E. Rubio ,&nbsp;Jaques Reifman ,&nbsp;Brittany Coats ,&nbsp;Kenneth L. Monson","doi":"10.1016/j.jmbbm.2025.107287","DOIUrl":"10.1016/j.jmbbm.2025.107287","url":null,"abstract":"<div><div>Repeated traumatic brain injury (TBI) is a significant concern among military personnel, athletes, and abuse victims. However, little is known about the mechanisms that drive the brain's apparent increase in injury susceptibility with repeated loading. One critical factor may be the softening of cerebral blood vessels, which are significantly stiffer than brain tissue and influence its mechanical response during trauma. In this study, we employed a finite element model of a Göttingen minipig head to investigate how progressive vascular softening influences strain changes in brain tissue during both repeated blast and rapid rotation. The model incorporated pig-specific anatomical detail and material properties, including detailed cerebral vasculature. Simulations included six repeated exposures of either blast overpressure or coronal or sagittal rotations at varying severity levels. Additional “no-vasculature” (NV) cases were included for each loading condition to benchmark the mechanical contribution of blood vessels. Vessel softening was applied after each exposure based on previous experiments on Göttingen minipig cerebral arteries. While blast exposures did not generate sufficient strain to induce vessel softening, rotational events led to progressively increasing brain strain with repetition, especially in regions adjacent to softened vessels. These increases progressed toward the NV condition with repetition, consistent with diminishing structural support by softened vessels. Results also showed increasing risk of vessel rupture and axonal injury with repetition. These findings elucidate the biomechanical role of vessel softening in repeated TBI and suggest that even sub-failure vessel damage may exacerbate brain strain in repeated exposures and elevate injury risk.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107287"},"PeriodicalIF":3.5,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viscoelastic phenotyping of meningiomas reveals biomechanical classes and intratumoral heterogeneity","authors":"Jan Saip Aunan-Diop ,&nbsp;José Bonilla ,&nbsp;Bo Halle ,&nbsp;Christian Bonde Pedersen ,&nbsp;Ancuta Ioana Friismose ,&nbsp;Bo Mussmann ,&nbsp;Frantz Rom Poulsen","doi":"10.1016/j.jmbbm.2025.107282","DOIUrl":"10.1016/j.jmbbm.2025.107282","url":null,"abstract":"<div><div>Tumor consistency influences meningioma handling during surgery, but systematic biomechanical classifications are lacking. In this prospective study, 129 tumor slices from 20 meningiomas underwent amplitude-sweep oscillatory rheometry (1–100% strain, 1 Hz) to characterize storage modulus (G′), loss modulus (G″), damping (tan δ), yield strain, and strain stiffening. Curves were normalized, embedded by principal component analysis, and subjected to unsupervised clustering. Three reproducible viscoelastic phenotypes were identified (Cluster A: 29%, B: 61%, C: 9%) that differed significantly across baseline stiffness, stiffening slope, yield strain, and damping (all q &lt; 1 × 10^-7). Cluster C, defined by high stiffness and elevated dissipation, was strongly associated with intraoperative hard grading (OR 82.8, 95% CI 11.0–623.2, p &lt; 0.0001). Tumor-level stiffness index correlated with overall consistency (ρ = 0.48, p = 0.033), and the hard-phenotype fraction tracked both maximum (ρ = 0.54, p = 0.013) and minimum consistency (ρ = 0.53, p = 0.017). Entropy-based heterogeneity did not predict surgical consistency range. Clustering robustness was confirmed by bootstrap (ARI 0.81) and leave-one-tumor-out analysis (ARI 0.79). These findings suggest a quantitative biomechanical classification of meningiomas directly linked to operative handling.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"174 ","pages":"Article 107282"},"PeriodicalIF":3.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of anisotropic biophysical properties of lower leg muscles at passive dorsiflexion and plantarflexion using magnetic resonance elastography and diffusion tensor imaging","authors":"Mahsa Salimi Majd ,&nbsp;Heiko Tzschätzsch ,&nbsp;Tom Meyer ,&nbsp;Noah Jaitner ,&nbsp;Yang Yang ,&nbsp;Neele Hattermann ,&nbsp;Alison N. Agres ,&nbsp;Georg N. Duda ,&nbsp;Steffen Görner ,&nbsp;Jürgen Braun ,&nbsp;Ingolf Sack ,&nbsp;Jing Guo","doi":"10.1016/j.jmbbm.2025.107285","DOIUrl":"10.1016/j.jmbbm.2025.107285","url":null,"abstract":"<div><div>Determining the biomechanical properties of skeletal muscle in-vivo is challenging due to structural anisotropy. In this study, we developed combined diffusion tensor imaging (DTI) and magnetic resonance elastography (MRE) to quantify direction-dependent biophysical properties of the lower leg muscles and their changes during passive plantarflexion (PF) and dorsiflexion (DF).</div><div>Thirteen male volunteers were studied using DTI-MRE. Anisotropic shear-wave-speeds parallel (<span><math><mrow><msub><mi>c</mi><mo>∥</mo></msub></mrow></math></span>) and perpendicular (<span><math><mrow><msub><mi>c</mi><mo>⊥</mo></msub></mrow></math></span>) to the fiber orientation were reconstructed by aligning MRE vector wave fields to the principal fiber axis with rotation angles obtained from DTI tractography. Isotropic <span><math><mrow><msub><mi>c</mi><mtext>iso</mtext></msub></mrow></math></span> was also calculated without rotation for comparison. Fractional anisotropy (FA), radial (RD) and axial diffusivity (AD) were obtained from DTI.</div><div><span><math><mrow><msub><mi>c</mi><mo>∥</mo></msub></mrow></math></span> was higher than <span><math><mrow><msub><mi>c</mi><mo>⊥</mo></msub></mrow></math></span> in tibialis anterior (TibA), whereas the opposite was observed in posterior soleus (SolP). From PF to DF, <span><math><mrow><msub><mi>c</mi><mo>⊥</mo></msub></mrow></math></span> and <span><math><mrow><msub><mi>c</mi><mo>∥</mo></msub></mrow></math></span> changed significantly in all muscles: TibA (−15 ± 11 %, −15 ± 13 %), SolP (8 ± 12 %, 9 ± 11 %), and gastrocnemius medialis (GasM) (11 ± 15 %, 21 ± 14 %), respectively (all p &lt; 0.05). <span><math><mrow><msub><mi>c</mi><mtext>iso</mtext></msub></mrow></math></span> was only sensitive in TibA (−13 ± 7 %) and GasM (4 ± 11 %), both p &lt; 0.05. For DTI, from PF to DF, FA and RD changed significantly in TibA (−20 ± 12 %, 10 ± 7 %), SolP (26 ± 12 %, −6±6 %), and GasM (19 ± 12 %, −5±7 %), respectively (all p &lt; 0.001). AD only changed in SolP (3 ± 5 %, p &lt; 0.01).</div><div>In conclusion, anisotropic MRE was more sensitive to ankle positions in lower leg muscles than isotropic MRE and revealed biomechanical differences between muscle types. In the future, DTI-MRE with anisotropic parameter reconstruction could be used for the detection of subtle structural changes in muscle diseases.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107285"},"PeriodicalIF":3.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A parametric analysis of interbody fusion cages placement: A finite elements approach comparing lumbar lordosis of bullet and steerable banana cages","authors":"Ibrahim El Bojairami ,&nbsp;Carlo Santaguida ,&nbsp;Salim Al Rawahi ,&nbsp;Ahmed Aoude ,&nbsp;Mark Driscoll","doi":"10.1016/j.jmbbm.2025.107281","DOIUrl":"10.1016/j.jmbbm.2025.107281","url":null,"abstract":"<div><h3>Introduction</h3><div>Improper cage placement during spinal interbody fusion surgeries could lead to numerous post-operative complications. Biomechanical factors of such improper placement may result in loss of lumbar lordosis, foraminal stenosis, subsidence, and altered stress distribution to the tissues adjacent to the cage.</div></div><div><h3>Objective</h3><div>The aim of the present study is to compare three different lumbar interbody cage designs, placed posterior, middle, and anterior, and their biomechanical effect on the aforementioned studied parameter.</div></div><div><h3>Methodology</h3><div>Cages and MRI-based lumbar spine models were developed using finite elements. A parametric comparative analysis was then designed to explore cage types, height, and location on lumbar lordosis, foraminal area, cage subsidence, along with normal and shear stresses resulting from each cage configuration under a 500 N compression load.</div></div><div><h3>Results</h3><div>First, the model was validated in light of published data. Simulated results showed that lumbar lordosis and foraminal area are inversely related. The 6-degrees bullet cage showed the highest gain in lordosis (16.5°), while it exhibited a large loss in foraminal area (34.2 mm²). Anterior placement of banana cages, however, showed the best trade-off, effectively recording a 14.5° lordosis gain, a 0.6 mm² loss in foraminal area, a subsidence as low as 0.27 mm, and a moderate cage stress of 13.6–23.1 MPa.</div></div><div><h3>Conclusions</h3><div>Reported data favors banana cages for the highest lordosis gains without compromising the other explored biomechanical factors. However, it is still advised to thoroughly consider patient-specific factors at hand, possible complications of foraminal stenosis, cage migration, and endplates wear prior to choosing an appropriate cage morphology and placement.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"174 ","pages":"Article 107281"},"PeriodicalIF":3.5,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable and osteoconductive sodium alginate-gelatin/amorphous magnesium phosphate 3D-printed scaffolds for craniofacial bone regeneration","authors":"Joyce R. de Souza ,&nbsp;Igor P. Mendes Soares ,&nbsp;Caroline Anselmi ,&nbsp;Prabaha Sikder ,&nbsp;Josimeri Hebling ,&nbsp;Alexandre L.S. Borges ,&nbsp;Eliandra S. Trichês ,&nbsp;Marco C. Bottino","doi":"10.1016/j.jmbbm.2025.107284","DOIUrl":"10.1016/j.jmbbm.2025.107284","url":null,"abstract":"<div><div>This study aimed (1) to develop and characterize 3D-printed hydrogel-based scaffolds composed of sodium alginate and gelatin containing amorphous magnesium phosphate (AMP), and (2) to evaluate the scaffolds’ biological response with alveolar bone–derived mesenchymal stem cells (aBMSCs). Hydrogel inks were prepared with sodium alginate, gelatin, calcium chloride, and varying AMP contents (0 %, 5 %, and 10 %). The scaffolds were fabricated using an extrusion-based 3D bioprinter. First, the formulated hydrogel-based inks were characterized for rheological behavior and printability. After printing, the scaffolds were assessed for morphology, chemical composition, mechanical properties, and swelling/degradation profiles. For <em>in vitro</em> cell-scaffold interaction, scaffolds were seeded with aBMSCs and analyzed for cell viability, matrix mineralization, and osteogenic gene expression via RT-qPCR. Statistical analysis was performed with ANOVA/Sidak or Tukey tests, with confidence intervals (α = 5 %). Rheological analysis showed that all inks exhibited shear-thinning behavior, more pronounced in AMP-containing formulations. Filament drop tests and printability assessments demonstrated filament uniformity and structural fidelity in AMP-containing inks. Morphological analysis revealed well-defined scaffold architecture with regular edges, and SEM confirmed smooth surface morphology with uniform AMP distribution. FTIR spectra displayed characteristic phosphate and polymer bands, while EDS confirmed the presence of magnesium and phosphorus in AMP-containing scaffolds. The swelling behavior increased over 24 h, and all 3D-printed scaffolds fully degraded within 35 days. All formulations supported increased cell viability over time (p ≤ 0.0092). AMP-containing scaffolds enhanced mineralized matrix deposition under osteogenic stimulation (p &lt; 0.0001), particularly in the 10 % AMP group, and promoted upregulation of osteogenic genes (COL1A1, ALPL, and RUNX2). Clinical significance: This study demonstrated that incorporating AMP into alginate-based hydrogels combines printability, biodegradability, and osteoconductive properties. Previous AMP-containing biomaterials lacked optimization for material extrusion-based 3D printing or the synergistic combination with a gelatin-alginate network. This strategy represents an advance in the field, offering a potential biomaterial ink for the fabrication of personalized scaffolds for craniofacial bone regeneration, enabling synergistic modulation of rheology and early osteogenic stimulation.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"174 ","pages":"Article 107284"},"PeriodicalIF":3.5,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive biomechanical material characterization of the human breast fibro-structural support system","authors":"Aroj Bhattarai ,&nbsp;Gregory P. Reece ,&nbsp;Kristy K. Brock ,&nbsp;Krishnaswamy Ravi-Chandar","doi":"10.1016/j.jmbbm.2025.107283","DOIUrl":"10.1016/j.jmbbm.2025.107283","url":null,"abstract":"<div><div>Breast surgery for aesthetic purposes, such as breast augmentation or breast reduction, and breast reconstruction after cancer treatment require an accurate structural (anatomical) and mechanical (functional) understanding of the breast components, including the fascial-ligamentous support system of the breast, to achieve optimal results. This paper aims to provide a comprehensive description of the mechanical behavior of the ligamentous and fascial connective tissues of the human female breast. Fasciae and ligaments obtained from 17 patients between 35 and 85 years of age who were undergoing mastectomy and three female cadavers were tested. Uniaxial tensile tests were conducted, and three constitutive models -- the phenomenological Fung exponential model, the invariant-based anisotropic Gasser-Ogden-Holzapfel model, and the meso-scale structural constitutive model -- were employed to fit the experimental stretch-stress curves. Our results show that the stiffness becomes consistent once collagen fibers are fully stretched, regardless of tissue type or patient factors. This paper presents a comprehensive mechanical characterization of all the connective tissues contributing to the fascial support structures of the breast, collectively termed here as the breast fibro-structural support (BFSS) system. A generalized stress-stretch curve with initial stretch as the only variable effectively captures patient-specific variability.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107283"},"PeriodicalIF":3.5,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145770384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}