Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"Structural finite element analysis of the lumbar spine applied to the conceptual design of a compliant interbody cage implant","authors":"Gabriele Cortis ,&nbsp;Alessandro Agostinelli ,&nbsp;Luca Cortese","doi":"10.1016/j.jmbbm.2025.107314","DOIUrl":"10.1016/j.jmbbm.2025.107314","url":null,"abstract":"<div><div>A detailed solid model of an entire lumbar segment is reconstructed through a reverse engineering approach based on a real patient Computed Tomography DICOM scan. The main structurally and functionally relevant elements have been considered in the model, including the L1-S1 vertebrae, intervertebral discs, ligaments, and the simplified structural and bracing effects of the principal lumbar muscles. Using the model, a structural Finite Element (FE) analysis is setup to provide an insight of stresses and range of motion of the “spinal mechanical system” under typical everyday as well as accidental loads. Organic bone, discs, ligaments physical and structural material data have been retrieved, and both static and fatigue load cases have been taken into account, collecting real world data from a review of literature works and of information available from accessible databases. A validation of the FE model is provided based on the so called Yamamoto protocol first, and then using experimental measurements performed on real patients, again taken from literature works. The numerical model proved to be accurate in the description of the stress states of the different parts of the spine and in reproducing the overall range of motion of the lumbar segment. A tentative design modification of rigid interbody cages and vertebral fixation systems used in present spinal fusion neurosurgery is then proposed, aimed at providing a certain level of compliance to the implant. This should restore a limited range of motion of the two adjacent vertebrae hosting the implant itself, reducing the possibility of subsequent adjacent segments diseases. The new cage and fixation system have been integrated in the FE model to replace a prospective “damaged” L4-L5 disc. The results of the numerical simulation demonstrated that the implant can withstand static and fatigue everyday life loads, as well as accidental overloads without failing. Additionally, the analysis showed that a limited mobility is maintained between the fused vertebrae.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107314"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A computational study of forward head posture biomechanics","authors":"Katterine N. Rios-Peralta ,&nbsp;Afonso J.C. Silva ,&nbsp;Ricardo J. Alves-de-Sousa ,&nbsp;Kathleen M. Curran ,&nbsp;David B. MacManus","doi":"10.1016/j.jmbbm.2025.107288","DOIUrl":"10.1016/j.jmbbm.2025.107288","url":null,"abstract":"<div><div>Forward head posture (FHP) is a common postural deviation linked to musculoskeletal disorders and altered cervical spine biomechanics. This study used a validated finite element model (C0–T1, THUMS v4.2) to quantify the biomechanical effects of FHP, with validation against cadaveric data for sagittal balance and range of motion in flexion–extension, axial rotation, and lateral bending. Sagittal balance parameters, including craniovertebral angle (CVA), occipital protuberance to C2 (OP–C2), cervical lordosis (C1–C2 and C2–C7), greater occipital nerve (GON), and C2 nerve root (C2–NR), were measured before and after a 2.5 cm anterior head displacement. FHP increased upper cervical lordosis and decreased lower cervical curvature, accompanied by measurable narrowing of neural foraminal spaces (GON and C2–NR) and elevated cortical bone stresses, particularly between C2–C3. These changes reflect compensatory adaptations that may predispose to pain and degeneration, underscoring the need for early intervention strategies to mitigate long-term spinal health impacts.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107288"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined experimental and micro finite element analysis of CF/PEEK pedicle screw pullout","authors":"Dominic Mischler ,&nbsp;Matteo Frigelli ,&nbsp;Ivan Zderic ,&nbsp;Michael Indermaur ,&nbsp;Patrik Wili ,&nbsp;Amin Dolati ,&nbsp;Philippe Zysset ,&nbsp;Peter Varga","doi":"10.1016/j.jmbbm.2025.107307","DOIUrl":"10.1016/j.jmbbm.2025.107307","url":null,"abstract":"<div><h3>Purpose</h3><div>Pedicle screw pull-out remains a challenge in thoracolumbar spine fixation, contributing to fixation failure. Computational simulations offer a pathway to optimize screw designs across diverse materials and bone qualities towards reducing failure rates. Non-linear explicit micro-finite element (μFE) simulation was hypothesized to accurately predict pullout forces of CF/PEEK screws, with bone volume fraction (BV/TV) influencing performance. This study aimed to validate the μFE model and assess BV/TV effects on the basis of experimental testing.</div></div><div><h3>Methods</h3><div>Thirteen cadaveric vertebrae were instrumented with 4.5 mm (n = 13) and 5.5 mm (n = 9) CF/PEEK screws using sample-specific 3D-printed guides. Quasi-static pullout tests were conducted and simulated using non-linear explicit μFE models based on high-resolution peripheral quantitative computed tomography (HR-pQCT). Regression analysis evaluated the relationship between BV/TV and pullout force. Correlation coefficient (R²), concordance correlation coefficient (CCC), standard error of estimate (SEE), and relative standard error (RSE) were used to assess the agreement between experimental and μFE-predicted pullout forces.</div></div><div><h3>Results</h3><div>The linear regression relationship between BV/TV and pullout force was significantly different for the 4.5 mm and 5.5 mm screws (p = 0.001). Ordinary least squares (OLS) regression showed significant BV/TV influence on pullout strength (p = 0.001 experimental, p &lt; 0.001 μFE). Linear regression in log10-log10 space for experimental versus μFE forces showed strong correlation (R² = 0.931, p &lt; 0.001), despite μFE overprediction (slope = 0.752 vs. 1:1, p &lt; 0.001; CCC = 0.745, SEE = 428.7 N, RSE = 85.2 %).</div></div><div><h3>Conclusions</h3><div>The validated μFE model accurately predicted pullout strength of pedicle screw of different designs, supported by strong correlation with experimental data, despite light overprediction, potentially due to the lack of insertion damage modeling. The robust <em>in silico</em> framework can be used to enhance orthopedic screw designs, supporting improved fixation stability across diverse bone qualities.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107307"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility in the morphological and mechanical properties of a natural polymer for guided bone regeneration applications","authors":"Benedetta Isella ,&nbsp;Aleksander Drinic ,&nbsp;Alissa Heim ,&nbsp;Hans Leemhuis ,&nbsp;Nadja Kröger ,&nbsp;Rene Tolba ,&nbsp;Alexander Kopp","doi":"10.1016/j.jmbbm.2025.107306","DOIUrl":"10.1016/j.jmbbm.2025.107306","url":null,"abstract":"<div><div>Dental barrier membranes play a key role in guided bone regeneration (GBR) to separate soft tissue from regenerating bone. Bioabsorbable collagen membranes, the gold standard in GBR procedures, are appealing due to elimination of the need for secondary surgeries and mechanical properties mimicking native tissue. However, challenges include rapid degradation, inconsistent reproducibility in mechanical and morphological properties, and use of animal-derived tissues. This study explored silk fibroin, a biocompatible and slowly bioabsorbable biomaterial as an alternative for GBR membranes. Silk fibroin showed comparable mechanical performance and demonstrated improved reproducibility. Two silk fibroin-based multilayered membranes (SF1 and SF2) were developed showing homogeneous appearance, density, and thickness, with lower variability than the other tested commercial options. These membranes exhibited elasto-plastic mechanical behaviour in both dry and hydrated states, supporting improved surgical handling and dimensional stability. Furthermore, elastic modulus in hydrated state (23.8 ± 3.2 MPa for SF1, 27.6 ± 3.9 MPa for SF2), burst pressure (17.5 ± 5.0 mmHg for SF1, 290.0 ± 32.6 mmHg for SF2), and force at first deformation in the suture retention strength test in hydrated state (0.10 ± 0.03 N for SF1, 0.26 ± 0.11 N for SF2) were comparable to commercial collagen membranes, suggesting the suitability for GBR applications. These findings provide a basis for further biological and preclinical characterization as well as clinical application of silk fibroin-based GBR membranes.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107306"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of plate working length on fatigue life in load bearing osteosynthesis constructs: Experimental insights and validated finite element predictions","authors":"Dominic Mischler ,&nbsp;Mark Glyde ,&nbsp;Michael Kowaleski ,&nbsp;Antoine Vautrin ,&nbsp;Simon Lambert ,&nbsp;Peter Varga","doi":"10.1016/j.jmbbm.2025.107322","DOIUrl":"10.1016/j.jmbbm.2025.107322","url":null,"abstract":"<div><h3>Background</h3><div>Fatigue failure of osteosynthesis plates in load bearing constructs remains a significant clinical challenge, with plate working length (PWL) influencing stress distribution and implant life span. Despite conflicting evidence on PWL's impact, finite element (FE) models offer potential for predicting fatigue life, yet their application to PWL-specific fatigue in bone-plate constructs is limited.</div></div><div><h3>Methods</h3><div>This study investigated the effect of PWL on fatigue life in load bearing constructs using experimental cyclic testing and FE modeling. Synthetic bone models with a 10 mm osteotomy gap were stabilized with 3.5 mm stainless steel locking compression plates, testing short (1 empty hole), medium (3 empty holes), and long (5 empty holes) PWL configurations (N = 6 per group) under sinusoidal loading (260 N peak, 3 Hz). A second sub-study assessed the medium PWL across nine load levels (220–380 N). FE models, validated against experimental force-displacement curves, predicted cycles to failure using Basquin's stress-based criteria. Statistical analyses compared experimental and FE-predicted cycles.</div></div><div><h3>Results</h3><div>Shorter PWL significantly increased fatigue life (short: 1.19 × 10⁶ ± 0.28 × 10⁶ cycles; medium: 0.35 × 10⁶ ± 0.07 × 10⁶; long: 0.20 × 10⁶ ± 0.04 × 10⁶; p &lt; 0.003). FE predictions closely matched experimental cycles for medium and long PWL (p &gt; 0.05) but underpredicted for short PWL (p = 0.03), likely due to tied interface assumptions. Most short PWL constructs survived beyond 10⁶ cycles, reaching up to 1.5 million cycles in the very high-cycle fatigue regime without failing, where Basquin's accuracy may decrease. Sub-study 2 showed a strong load-life correlation (R² = 0.96), with FE predictions achieving high accuracy (CCC = 0.972, REE = 6.3 %).</div></div><div><h3>Conclusion</h3><div>Shorter PWL enhances fatigue life in load bearing constructs by reducing plate stress, challenging traditional beliefs favoring longer PWL. FE models effectively predict fatigue life for medium and long PWL, supporting preoperative optimization, but require refinement for short PWL, including frictional contact modeling and alternative fatigue models for very high-cycle fatigue. Validation in physiological conditions is needed to enhance clinical applicability.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107322"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical evaluation of load transfer in Talus focal resurfacing implant: experimental and finite element models","authors":"A. Ramos,&nbsp;M. Vieira","doi":"10.1016/j.jmbbm.2025.107300","DOIUrl":"10.1016/j.jmbbm.2025.107300","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteochondral lesions (OTLs) are common injuries in ankle sprains, occurring in up to 70 % of patients. Recovery options are limited due to the talus bone's poor vascularization. This study aimed to develop a computational model of an ankle joint to evaluate cartilage stress in the presence of an OTL and assess the biomechanical effectiveness of a focal resurfacing prosthesis in reducing joint stress.</div></div><div><h3>Materials and methods</h3><div>Both in silico and physical model models were developed based on a previous case study involving a patient with a medial OTL in the right ankle. A 10 mm diameter focal resurfacing prosthesis was tested in two positions: proud (+0.5 mm) and recessed (−0.5 mm), as recommended in clinical guidelines. Cartilage stress and trabecular bone strain in the talus were evaluated. The in vitro model, produced via additive manufacturing and instrumented with strain gauges, was used to validate the finite element (FE) model by comparing measured and simulated strains.</div></div><div><h3>Results</h3><div>The FE model showed strong agreement with experimental data, with a correlation coefficient of 0.88. Both the lesion and prosthesis placement influenced talar cartilage stress. The OTL increased stress by approximately 23 % near the lesion site and 8 % in more distal regions. The highest cartilage stress (7.20 MPa) occurred with the prosthesis in the recessed position. Prosthesis positioning significantly affected cartilage stress distribution (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>While fixation of the focal prosthesis remains challenging, placing it slightly proud can help reduce stress on talar cartilage. However, excessive proud positioning increases stress on tibial cartilage and should be avoided. Proper prosthesis placement is critical for optimal stress reduction. Furthermore, fixation in the talus reduces trabecular bone strain, potentially mitigating bone loss and enhancing implant stability.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107300"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrodeposited biodegradable Zn-Fe alloy foams: Synergistic control of degradation kinetics and biomechanical properties for cranial bone implants","authors":"Lin Liu ,&nbsp;Xuan Luo ,&nbsp;Zexin Liu ,&nbsp;Kun Chen ,&nbsp;Xiaokangbo Li ,&nbsp;Yang Gao ,&nbsp;Zeqin Cui ,&nbsp;Runhua Yao ,&nbsp;Xiaotong Lu ,&nbsp;Ruiqiang Hang ,&nbsp;Xiaohong Yao","doi":"10.1016/j.jmbbm.2025.107330","DOIUrl":"10.1016/j.jmbbm.2025.107330","url":null,"abstract":"<div><div>Critical-sized craniocerebral defects pose significant reconstruction challenges due to inadequate self-repair capacity and limitations of autologous bone grafts. Addressing this, we pioneer biodegradable Zn-Fe alloy foams fabricated via dual-anode co-deposition, which overcomes elemental segregation in conventional gradient-coated foams, to achieve integrated mechanical and degradation properties. By tailoring deposition current (0.4–0.6 A), electrolyte pH (2.8–3.0), and temperature (25–35 °C), this study establishes a critical link between process-induced microstructural evolution and the resultant scaffold performance in critical-sized cranial defect repair. Key results demonstrate: current-induced densification and pH-mediated defect control enable mechanically-optimized architectures with Plastic Collapse Stress (PCS, 151 ± 6 kPa) and Compressive Young's Modulus (CYM, 500 ± 19 kPa). Degradation kinetics self-regulate physiological pH (7.5–8.0) via mineralized byproducts (Ca₃Fe₂(OH)₁₂/Zn(OH)₂), with degradation rates tunable to 17.67–44.14 mm/y while sustaining &gt;95 % osteoblast viability through controlled Zn²⁺/Fe³⁺ release (1.20–1.69/0.25–0.73 mg/L). The 0.5 A/pH = 3.0/30 °C parameters emerge as a clinically translatable solution, concurrently satisfying cranial bone-matching degradation, biomechanics, and biocompatibility.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107330"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of anisotropic biophysical properties of lower leg muscles at passive dorsiflexion and plantarflexion using magnetic resonance elastography and diffusion tensor imaging","authors":"Mahsa Salimi Majd ,&nbsp;Heiko Tzschätzsch ,&nbsp;Tom Meyer ,&nbsp;Noah Jaitner ,&nbsp;Yang Yang ,&nbsp;Neele Hattermann ,&nbsp;Alison N. Agres ,&nbsp;Georg N. Duda ,&nbsp;Steffen Görner ,&nbsp;Jürgen Braun ,&nbsp;Ingolf Sack ,&nbsp;Jing Guo","doi":"10.1016/j.jmbbm.2025.107285","DOIUrl":"10.1016/j.jmbbm.2025.107285","url":null,"abstract":"<div><div>Determining the biomechanical properties of skeletal muscle in-vivo is challenging due to structural anisotropy. In this study, we developed combined diffusion tensor imaging (DTI) and magnetic resonance elastography (MRE) to quantify direction-dependent biophysical properties of the lower leg muscles and their changes during passive plantarflexion (PF) and dorsiflexion (DF).</div><div>Thirteen male volunteers were studied using DTI-MRE. Anisotropic shear-wave-speeds parallel (<span><math><mrow><msub><mi>c</mi><mo>∥</mo></msub></mrow></math></span>) and perpendicular (<span><math><mrow><msub><mi>c</mi><mo>⊥</mo></msub></mrow></math></span>) to the fiber orientation were reconstructed by aligning MRE vector wave fields to the principal fiber axis with rotation angles obtained from DTI tractography. Isotropic <span><math><mrow><msub><mi>c</mi><mtext>iso</mtext></msub></mrow></math></span> was also calculated without rotation for comparison. Fractional anisotropy (FA), radial (RD) and axial diffusivity (AD) were obtained from DTI.</div><div><span><math><mrow><msub><mi>c</mi><mo>∥</mo></msub></mrow></math></span> was higher than <span><math><mrow><msub><mi>c</mi><mo>⊥</mo></msub></mrow></math></span> in tibialis anterior (TibA), whereas the opposite was observed in posterior soleus (SolP). From PF to DF, <span><math><mrow><msub><mi>c</mi><mo>⊥</mo></msub></mrow></math></span> and <span><math><mrow><msub><mi>c</mi><mo>∥</mo></msub></mrow></math></span> changed significantly in all muscles: TibA (−15 ± 11 %, −15 ± 13 %), SolP (8 ± 12 %, 9 ± 11 %), and gastrocnemius medialis (GasM) (11 ± 15 %, 21 ± 14 %), respectively (all p &lt; 0.05). <span><math><mrow><msub><mi>c</mi><mtext>iso</mtext></msub></mrow></math></span> was only sensitive in TibA (−13 ± 7 %) and GasM (4 ± 11 %), both p &lt; 0.05. For DTI, from PF to DF, FA and RD changed significantly in TibA (−20 ± 12 %, 10 ± 7 %), SolP (26 ± 12 %, −6±6 %), and GasM (19 ± 12 %, −5±7 %), respectively (all p &lt; 0.001). AD only changed in SolP (3 ± 5 %, p &lt; 0.01).</div><div>In conclusion, anisotropic MRE was more sensitive to ankle positions in lower leg muscles than isotropic MRE and revealed biomechanical differences between muscle types. In the future, DTI-MRE with anisotropic parameter reconstruction could be used for the detection of subtle structural changes in muscle diseases.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107285"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical spine posture, but not head-end motion constraints, governs the kinematic and kinetic response in sub-injurious axial impacts","authors":"Darcy W. Thompson-Bagshaw PhD ,&nbsp;Ryan D. Quarrington PhD ,&nbsp;Peter A. Cripton PhD ,&nbsp;Claire F. Jones PhD","doi":"10.1016/j.jmbbm.2025.107321","DOIUrl":"10.1016/j.jmbbm.2025.107321","url":null,"abstract":"<div><div>Head-first impacts can produce traumatic cervical spine injuries resulting in tetraplegia. These injury patterns are thought to relate to the alignment of the loading vector relative to the spinal column. Pre-impact posture and subsequent head and intervertebral kinematics, including spinal buckling and head motion relative to the spine and torso, can generate complex spinal configurations. These motions often precede injury onset and can be observed with <em>ex vivo</em> models in which applied loads remain below injury thresholds. This study examined the kinematic response of the cervical spine to dynamic axial compression at sub-injurious severities, enabling inter- and intra-specimen comparisons across varying initial spinal postures and head motion constraints. Human cervical spine specimens (N = 7) were subjected to repeated 1 m/s axial impacts, while the applied head constraint (sagittal rotation and/or anterior translation) and initial posture (anterior eccentricity and curvature) were varied. Pre-impact head–T1 eccentricity and curvature, head-end motion during impact, intervertebral kinematics, and impact loads were recorded. Head-end anterior translation and flexion rotation were minimal across all constraint conditions (&lt;11.5 mm, &lt;9.0°). Head constraint had no detected effect on peak force (541–2457 N), deformation (3.2–11 mm), or stiffness (81–1074 N/mm) (all p &gt; 0.05). In contrast, greater initial curvature and eccentricity reduced stiffness and peak force, and increased deformation (p &lt; 0.05). Greater initial curvature also produced larger changes in intervertebral flexion-extension during impact (p &lt; 0.05). These results demonstrate that pre-impact posture dictates the cervical spine's sub-injurious axial response at discrete anterior eccentricities, which may be further explored using computational models validated using this dataset.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107321"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Corrosion-fatigue of additively manufactured Ti6Al4V” [J. Mech. Behav. Biomed. Mater. 175 107289]","authors":"William W. Hogg,&nbsp;Mueed Jamal,&nbsp;Nathaniel W. Zuckschwerdt,&nbsp;Cohen M. Hess,&nbsp;Susmita Bose,&nbsp;Amit Bandyopadhyay","doi":"10.1016/j.jmbbm.2025.107304","DOIUrl":"10.1016/j.jmbbm.2025.107304","url":null,"abstract":"","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"175 ","pages":"Article 107304"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}