Journal of the Mechanical Behavior of Biomedical Materials最新文献_第2页

Associations between age and mechanical properties in skeletally immature human patellar tendons 骨骼未成熟的人髌骨肌腱的年龄和力学特性之间的关系

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2026-01-07 DOI: 10.1016/j.jmbbm.2026.107341

Luke T. Mattar , Svenja A. Höger , Anja M. Wackerle , Jayson J. Baggett , Armin Runer , Kevin G. Shea , Volker Musahl , Richard E. Debski

The objective was to quantify the mechanical properties of the central region of skeletally immature human patellar tendons and the associations with age. Twenty-six patella-patellar tendon complexes were examined (range 0.1–9.9 years, 17 males, 9 females). The cross-sectional area at the midsubstance of the native and dog-boned patellar tendons were measured using a 3D laser scanning system. The patellar tendons underwent a mechanical testing protocol to failure with loading criteria normalized to cross-sectional area. Associations between mechanical properties, native cross-sectional area, and age were determined using Pearson or Spearman's correlations. The only association observed between age and mechanical properties was a positive association between age and ultimate stress (R² = 0.21, p = 0.02), thus as age increased, the ultimate stress increased. No association between age and modulus was found (p > 0.05). A positive association between age and native cross-sectional area was observed (R² = 0.64, p = 0.001). Furthermore, 46 % of specimens lacked a typical toe region of the stress-strain curve. Increased ultimate stress with age may indicate the patellar tendon adapts throughout maturation to increase the force per unit area withstood before failing. In combination with the increases in native cross-sectional area, the patellar tendon may adapt to increased loading occurring at the knee throughout maturation at the macrostructural and microstructural levels. The lack of a toe region in some patellar tendons may indicate additional differences in tissue architecture such as smaller collagen crimp angles, more collagen cross-linking, or lower elastin concentrations. Thus, the current study provides information on changes in tissue function throughout growth and development.

目的是量化骨未成熟人类髌骨肌腱中心区域的力学特性及其与年龄的关系。对26例髌骨-髌骨肌腱复合体进行了检查（年龄范围0.1-9.9岁，男性17例，女性9例）。使用3D激光扫描系统测量原生和狗骨髌骨肌腱中间物质的横截面积。髌骨肌腱进行了力学测试，加载标准归一化为横截面积。力学性能、自然横截面积和年龄之间的关系采用Pearson或Spearman相关来确定。年龄与力学性能之间的唯一相关关系是年龄与极限应力之间的正相关关系（R2 = 0.21, p = 0.02），因此随着年龄的增加，极限应力增加。年龄与模量之间无相关性（p > 0.05）。年龄与原生横截面积呈正相关（R2 = 0.64, p = 0.001）。此外，46%的试件缺乏典型的应力-应变曲线脚趾区域。随着年龄增长而增加的极限应力可能表明髌腱在整个成熟过程中适应在失效前增加单位面积承受的力。结合固有横截面积的增加，髌骨肌腱可以在宏观结构和微观结构水平上适应膝关节在成熟过程中增加的负荷。某些髌骨肌腱缺少趾区可能表明组织结构存在其他差异，如胶原卷曲角度较小、胶原交联较多或弹性蛋白浓度较低。因此，目前的研究提供了在生长发育过程中组织功能变化的信息。

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引用次数: 0

Modeling thoracolumbar fascia mechanical tensile behavior with microstructure-level descriptors 用微结构级描述符模拟胸腰椎筋膜力学拉伸行为

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2026-01-06 DOI: 10.1016/j.jmbbm.2025.107317

Alexandre Lagache , Jérémie Girardot , Claudio Vergari , Sébastien Laporte

Modeling of fasciae remains limited, despite their recognized role in chronic pain. Developing a comprehensive mechanical model of fasciae could significantly enhance our understanding of their pain-related mechanisms and improve their prevention. This paper presents a computational approach capable of simulating the mechanical behavior of fibrous tissues based on their mesostructure. The thoracolumbar fascia was selected as a case study due to the availability of its experimentally derived mechanical properties in the literature. A discrete element model was developed, representing collagen fibers as bilinear springs and the proteoglycan matrix as elastic beams. The model was subjected to uniaxial tensile tests across various parameter sets defining fiber threshold distributions. Four test configurations were implemented to evaluate key aspects of the model: the influence of fiber properties, validation against experimental data, anisotropic response, and the role of inter-fiber contact. The simulations revealed a broad range of hyperelastic behaviors resulting from subtle variations in fiber properties, suggesting potential adaptability across different fascia types. The numerical outcomes closely matched experimental results, despite the absence of a precise microstructural description of the tested samples. The model demonstrated anisotropic behavior aligned with the preferential fiber orientations, as expected in fibrous tissues. Additionally, contact interactions produced internal force reactions and localized stress within the sample. Overall, the proposed model successfully reproduced experimental tensile behavior while offering valuable insights into local mechanical responses and anisotropy, contributing to a better understanding of fascia mechanics and their potential role in chronic pain.

Significance statement

Growing evidence links chronic low back pain to altered mechanical properties of the thoracolumbar fascia. As fascia mechanics emerges from its fibrous mesostructure, elucidating this relationship is crucial. Yet, no existing numerical models directly derive macroscopic mechanical behavior from mesoscale structural organization. We developed a discrete element model that predicts the thoracolumbar fascia’s mechanical response from its mesostructural architecture. Validated against previous experimental tensile data, the model accurately reproduced the fascia’s elastic behavior. By quantitatively bridging mesostructure and mechanical response within the elastic range, this work provides a numerical framework to explore how fascial architecture governs the tissue mechanical properties which contribute to pain mechanisms.

尽管筋膜在慢性疼痛中起着公认的作用，但其建模仍然有限。建立一个全面的筋膜力学模型可以大大提高我们对其疼痛相关机制的理解，并改善其预防。本文提出了一种基于纤维组织细观结构模拟纤维组织力学行为的计算方法。选择胸腰筋膜作为案例研究，是因为在文献中有实验得出的力学特性。建立了离散元模型，将胶原纤维表示为双线性弹簧，将蛋白聚糖基质表示为弹性梁。该模型在定义纤维阈值分布的各种参数集上进行了单轴拉伸试验。采用了四种测试配置来评估模型的关键方面：纤维特性的影响、实验数据的验证、各向异性响应以及纤维间接触的作用。模拟揭示了纤维特性的细微变化导致的广泛的超弹性行为，表明了不同筋膜类型的潜在适应性。数值结果与实验结果密切匹配，尽管缺乏测试样品的精确微观结构描述。该模型显示各向异性行为与纤维组织中的优先纤维取向一致。此外，接触相互作用在样品内产生内力反应和局部应力。总的来说，所提出的模型成功地再现了实验拉伸行为，同时为局部力学反应和各向异性提供了有价值的见解，有助于更好地理解筋膜力学及其在慢性疼痛中的潜在作用。越来越多的证据表明慢性腰痛与胸腰筋膜力学特性的改变有关。筋膜力学是从纤维细观结构中产生的，阐明这种关系是至关重要的。然而，目前还没有直接从中尺度结构组织中推导宏观力学行为的数值模型。我们开发了一个离散单元模型，从介观结构结构来预测胸腰椎筋膜的力学响应。与先前的实验拉伸数据进行了验证，该模型准确地再现了筋膜的弹性行为。通过在弹性范围内定量地桥接介观结构和力学响应，这项工作为探索筋膜结构如何控制有助于疼痛机制的组织力学特性提供了一个数值框架。

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引用次数: 0

Agarose as a tissue mimic for porcine kidney at the micro-length scale 琼脂糖作为猪肾微尺度组织模拟物的研究。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2026-01-05 DOI: 10.1016/j.jmbbm.2026.107332

Aadarsh Mishra , Riaz Akhtar , Robin O. Cleveland

Agarose gels are frequently utilized to simulate tissue. This study aimed to find an appropriate agarose concentration that matches the mechanical characteristics of pig kidney at the micro length scale and compare these to macro-scale properties. For all agarose samples and porcine kidneys, the shear storage modulus and loss modulus were measured at the micro-length scale using nanoindentation measurements with a 100 μm diameter probe, for frequencies from 10 Hz to 110 Hz. Measurements at the macro-length scale were carried out with a rheometer from 0.1 Hz to a maximum of 9.5 Hz at a shear strain amplitude of 0.1 % and fit to a fractional derivative mechanical model. The storage modulus at the micro-length scale was higher by factor of 1.2–70 than the storage modulus at macro-length scale in kidney samples and agarose (depending on agarose concentration), which was linked to gel and tissue microstructure. An agarose concentration of 1.2 % best fitted the kidney tissue properties at microscale.

琼脂糖凝胶经常被用来模拟组织。本研究旨在寻找合适的琼脂糖浓度，以匹配猪肾脏在微观尺度上的力学特性，并将其与宏观尺度上的特性进行比较。对于所有琼脂糖样品和猪肾，使用直径为100 μm的纳米压痕测量，在10 Hz至110 Hz的频率范围内测量了剪切储存模量和损失模量。在宏观长度尺度上，在0.1 Hz至最大9.5 Hz的剪切应变幅度为0.1%的情况下，使用流变仪进行测量，并适合分数阶导数力学模型。肾脏样品和琼脂糖（取决于琼脂糖浓度）在微长度尺度上的存储模量比在大长度尺度上的存储模量高1.2-70倍，这与凝胶和组织微观结构有关。琼脂糖浓度为1.2%最适合微尺度下的肾脏组织特性。

引用次数: 0

Biomimetic PEEK implants with hierarchical mechanics and enhanced bioactivity 具有分层力学和增强生物活性的仿生PEEK植入物。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-12-30 DOI: 10.1016/j.jmbbm.2025.107325

Junfeng Zhang , Zhanpeng Liu , Qili Sun , Ye Tian , Jing Nie , Enze Zhao , Fenbo Ma , Bin Tang , Shuaishuai Cao

Polyetheretherketone (PEEK) exhibits significant potential in orthopedic implant applications due to its elastic modulus closely resembling that of natural bone; however, its inherently bioinert surface limits the efficacy of osseointegration. Inspired by natural biomineralization processes, this study developed an innovative coating strategy based on microbially induced calcium carbonate precipitation (MICP). Through sulfonation treatment of PEEK (SPEEK), a calcium carbonate bioactive coating enriched with calcium and magnesium elements was constructed on its surface using Sporosarcina pasteurii. Characterization results revealed that the coating exhibited a microporous structure, superhydrophilicity, and a depth-dependent modulus gradient (decreasing from 6.5 GPa to 4.5 GPa) along with mechanical heterogeneity from the surface to the substrate, successfully mimicking the hierarchical mechanical architecture of native bone. In vitro cellular experiments demonstrated that SPEEK-MICP-6D significantly enhanced the proliferation, viability, and expression of osteogenesis-related genes (ALP, Runx2, Col1, BSP) in MC3T3-E1 preosteoblasts. This enhanced bioactivity was primarily attributed to the sustained release of calcium and magnesium ions from the coating, coupled with its biomimetic mechanical microenvironment. The MICP modification method offers advantages of low cost, sustainability, and scalability, providing a highly promising platform for the development of next-generation PEEK orthopedic implants that integrate biomimetic mechanical properties with enhanced bioactivity.

聚醚醚酮（PEEK）由于其弹性模量与天然骨非常相似，在骨科植入物应用中表现出巨大的潜力；然而，其固有的生物惰性表面限制了骨整合的效果。受自然生物矿化过程的启发，本研究开发了一种基于微生物诱导碳酸钙沉淀（MICP）的创新涂层策略。通过磺化处理PEEK (SPEEK)，利用巴氏孢杆菌在其表面构建了富含钙、镁元素的碳酸钙生物活性涂层。表征结果表明，该涂层具有微孔结构、超亲水性和深度相关的模量梯度（从6.5 GPa降至4.5 GPa），并且具有从表面到基体的力学不均匀性，成功地模仿了天然骨的分层力学结构。体外细胞实验表明，speik - micp - 6d显著增强MC3T3-E1成骨前细胞的增殖、活力和成骨相关基因（ALP、Runx2、Col1、BSP）的表达。这种增强的生物活性主要归因于钙和镁离子从涂层中持续释放，再加上其仿生机械微环境。MICP改性方法具有低成本、可持续性和可扩展性的优点，为下一代PEEK骨科植入物的开发提供了一个非常有前途的平台，该植入物将仿生机械性能与增强的生物活性相结合。

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引用次数: 0

Electrodeposited biodegradable Zn-Fe alloy foams: Synergistic control of degradation kinetics and biomechanical properties for cranial bone implants 电沉积可生物降解的锌铁合金泡沫：颅骨植入物降解动力学和生物力学性能的协同控制

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-12-30 DOI: 10.1016/j.jmbbm.2025.107330

Lin Liu , Xuan Luo , Zexin Liu , Kun Chen , Xiaokangbo Li , Yang Gao , Zeqin Cui , Runhua Yao , Xiaotong Lu , Ruiqiang Hang , Xiaohong Yao

Critical-sized craniocerebral defects pose significant reconstruction challenges due to inadequate self-repair capacity and limitations of autologous bone grafts. Addressing this, we pioneer biodegradable Zn-Fe alloy foams fabricated via dual-anode co-deposition, which overcomes elemental segregation in conventional gradient-coated foams, to achieve integrated mechanical and degradation properties. By tailoring deposition current (0.4–0.6 A), electrolyte pH (2.8–3.0), and temperature (25–35 °C), this study establishes a critical link between process-induced microstructural evolution and the resultant scaffold performance in critical-sized cranial defect repair. Key results demonstrate: current-induced densification and pH-mediated defect control enable mechanically-optimized architectures with Plastic Collapse Stress (PCS, 151 ± 6 kPa) and Compressive Young's Modulus (CYM, 500 ± 19 kPa). Degradation kinetics self-regulate physiological pH (7.5–8.0) via mineralized byproducts (Ca₃Fe₂(OH)₁₂/Zn(OH)₂), with degradation rates tunable to 17.67–44.14 mm/y while sustaining >95 % osteoblast viability through controlled Zn²⁺/Fe³⁺ release (1.20–1.69/0.25–0.73 mg/L). The 0.5 A/pH = 3.0/30 °C parameters emerge as a clinically translatable solution, concurrently satisfying cranial bone-matching degradation, biomechanics, and biocompatibility.

由于自身修复能力不足和自体骨移植的局限性，临界尺寸的颅脑缺损带来了重大的重建挑战。为了解决这一问题，我们首创了通过双阳极共沉积制造可生物降解的锌铁合金泡沫，克服了传统梯度涂层泡沫中的元素偏析，实现了综合机械和降解性能。通过调整沉积电流（0.4-0.6 A）、电解质pH（2.8-3.0）和温度（25-35°C），本研究在临界尺寸颅骨缺损修复中建立了过程诱导的微观结构演变与由此产生的支架性能之间的关键联系。关键结果表明：电流诱导致密化和ph介导的缺陷控制可以实现塑性崩溃应力（PCS, 151±6 kPa）和压缩杨氏模量（CYM, 500±19 kPa）的机械优化结构。降解动力学通过矿化副产物(Ca3Fe2（OH)12/Zn(OH)2）自我调节生理pH(7.5-8.0)，降解速率可调至17.67-44.14 mm/y，同时通过控制Zn2+/Fe3+释放（1.20-1.69/0.25-0.73 mg/L）维持95%的成骨细胞活力。0.5 A/pH = 3.0/30°C参数成为临床可翻译的解决方案，同时满足颅骨匹配降解，生物力学和生物相容性。

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引用次数: 0

Calibration of Drucker–Prager plasticity in prosthetic materials: From experimental characterization to reverse-engineering finite element analysis 假肢材料的Drucker-Prager塑性校正：从实验表征到逆向工程有限元分析

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-12-30 DOI: 10.1016/j.jmbbm.2025.107328

Christoph Moos , Stefan Kolling , Bernd Wöstmann , Maximiliane Amelie Schlenz , Sebastian Wille

Objective:

Accurate simulation of prosthetic materials requires constitutive models that capture pressure sensitivity and tension–compression asymmetry beyond linear elasticity.

Methods:

This study presents a reverse-engineering workflow to calibrate a Drucker–Prager based constitutive model in LS-DYNA using the semi-analytical model for polymers MAT 187L SAMP Light for a resin composite (Brilliant Crios) and a polymer-infiltrated ceramic network (Vita Enamic). Unconfined uniaxial compression, three-point bending, and Brazilian disc tests provide elastic constants and strength measures that serve as inputs and calibration targets. An analytical initialization maps experimentally determined yield stresses to the linear Drucker–Prager yield surface, supplying reliable starting parameters for finite element reverse-engineering optimization.

Results:

The calibrated model captures the material response in the calibration tests (three-point bending and Brazilian disc) within the pre-peak regime, and an out-of-sample punch-through test confirms the transferability of the parameters without additional tuning. Compared to von Mises characterization approaches, the pressure-dependent characterization was achieved with only one additional test configuration, shifting effort from experiments to numerical computation optimization.

Significance:

Within these limits, the results support pressure-dependent, asymmetric plasticity as a practical basis for predictive finite element analysis of dental restoratives, while highlighting that explicit damage and strain-rate effects should be incorporated in future work to model softening and failure consistently.

目的：假肢材料的精确模拟需要本构模型能够捕捉线性弹性之外的压力敏感性和拉压不对称性。方法：本研究提出了一种逆向工程工作流程，使用聚合物MAT 187L SAMP Light半解析模型校准LS-DYNA中基于Drucker-Prager的本构模型，该模型适用于树脂复合材料（Brilliant Crios）和聚合物渗透陶瓷网络（Vita Enamic）。无侧限单轴压缩、三点弯曲和巴西圆盘测试提供弹性常数和强度测量，作为输入和校准目标。解析初始化将实验确定的屈服应力映射到线性Drucker-Prager屈服面，为有限元逆向工程优化提供可靠的起始参数。结果：校准模型捕获了峰前状态下校准测试（三点弯曲和巴西圆盘）中的材料响应，样品外穿孔测试确认了参数的可转移性，而无需额外调整。与von Mises表征方法相比，压力相关表征仅通过一个额外的测试配置即可实现，将工作从实验转移到数值计算优化。意义：在这些限制范围内，结果支持压力依赖、不对称塑性作为牙科修复体预测有限元分析的实用基础，同时强调在未来的工作中应纳入明确的损伤和应变率效应，以一致地模拟软化和破坏。

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引用次数: 0

Fracture resistance of a short fiber-reinforced flowable resin composite compared with different types of flowable resin composites 短纤维增强可流动树脂复合材料与不同类型可流动树脂复合材料的抗断裂性能比较

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-12-30 DOI: 10.1016/j.jmbbm.2025.107327

Shuhei Watanabe , Toshiki Takamizawa , Rei Muto , Shunichi Suda , Ryo Ishii , Mark A. Latta , Wayne W. Barkmeier , Masashi Miyazaki

Objectives

This study aimed to evaluate the fracture resistance of a short fiber-reinforced flowable resin composite and compare it with that of different types of flowable resin composites.

Methods

A total of 10 commercially available flowable resin composites were used, including a flowable short fiber-reinforced resin composite (SFRC), five bulk-fill flowable resin composites, two injectable resin composites, and two single-shade flowable resin composites. The flexural strength (σ_F), flexural modulus, and resilience (R) were measured using a three-point bending flexural test. Additionally, a fatigue flexural strength (FFS) test was performed using repeated subcritical loading at a frequency of 20 Hz for 50,000 cycles. The fracture toughness (K_IC) was measured using the single-edge notched beam three-point bending test. All tests were performed after 24 h of storage or 10,000 thermal cycles.

Results

The flowable SFRC demonstrated significantly higher σ_F, FFS, and K_IC than the other flowable resin composites. However, all the flowable resin composites demonstrated statistically significant reductions in σ_F, R, FFS, and K_IC after thermal cycles compared with those at baseline.

Significance

The flowable SFRC had superior fracture resistance under external force, not only under a monotonic static load but also under repeated subcritical load stress. The findings indicate that the flowable SFRC is a promising resin composite due to its superior outcomes in the FFS test and other fracture resistance tests.

目的评价短纤维增强可流动树脂复合材料的抗断裂性能，并与不同类型的可流动树脂复合材料进行比较。方法采用10种市售可流动树脂复合材料，包括1种可流动短纤维增强树脂复合材料（SFRC）、5种散装填充可流动树脂复合材料、2种可注射树脂复合材料和2种单色可流动树脂复合材料。采用三点弯曲试验法测定了材料的抗弯强度（σF）、抗弯模量（σF）和回弹性(R)。此外，还进行了疲劳弯曲强度（FFS）测试，使用频率为20 Hz的重复亚临界载荷进行了50,000次循环。采用单刃缺口梁三点弯曲试验测量断裂韧性（KIC）。所有测试均在24小时储存或10,000次热循环后进行。结果可流动SFRC的σF、FFS和KIC明显高于其他可流动树脂复合材料。然而，与基线相比，所有可流动树脂复合材料在热循环后的σF、R、FFS和KIC均有统计学上的显著降低。意义可流动SFRC不仅在单调静载荷作用下，而且在重复亚临界载荷应力作用下均具有较好的抗外力断裂性能。研究结果表明，可流动SFRC在FFS试验和其他抗断裂试验中表现优异，是一种很有前途的树脂复合材料。

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引用次数: 0

Surface and microstructural properties of denture base materials: Effects of manufacturing techniques, surface treatments, and aging protocols 义齿基托材料的表面和微观结构特性：制造技术、表面处理和老化方案的影响

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-12-29 DOI: 10.1016/j.jmbbm.2025.107331

Laura Brose , Andreas Koenig , Paul Kemmesies , Saba Tamjidtash , Nadine Kommerein , Katharina Doll-Nikutta , Meike Stiesch , Martin Rosentritt , Sebastian Hahnel

Objectives

Understanding denture base material properties under aging conditions is crucial for assessing their clinical performance and impact on oral health. This study evaluated the behaviour of polymethylmethacrylate (PMMA), dimethacrylate-based polymers (DMA), and polyetheretherketone (PEEK) denture base materials after aging (thermal, mechanical, chemical), based on parameters (surface, mechanical, sorptive, structural) and considering manufacturing techniques (auto-curing, milling, 3D printing).

Material and methods

Disc-shaped specimens (2 mm × 8 mm, n = 10 per group; total n = 500) were manufactured from five denture base materials: PMMA (auto-curing, milling), DMA (3D printing: 90°/45° orientation), PEEK (milling). Standardized rough or fine surfaces were applied. Specimens underwent separate aging protocols: thermocycling, toothbrush abrasion, storage in HCl/NaOCl. Surface and material properties were analyzed prior and after aging. Data were evaluated using non-parametric tests (Kruskal-Wallis, Mann-Whitney U, α = 0.05). Effect sizes were calculated.

Results

Compared to other materials, PEEK showed few significant changes in surface parameters, microhardness, and indentation after aging. All materials exhibited strong effect sizes for water absorption and solubility (r ≥ 0.85∗∗∗). In PMMA, aging significantly reduced surface and mechanical properties, especially in rough-treated specimens. DMA printed with 90° was less affected by aging than with 45°, particularly after fine treatment. Milled PMMA with fine treatment showed the highest aging resistance among PMMA variants. Generally, rough surfaces were more susceptible to aging than fine surfaces.

Conclusion

Aging resistance of denture base materials depends on surface treatment, material, and manufacturing technique. Adequate polishing reduces aging effects on surface and mechanical properties. Milling yields reliable results, while 3D printing requires further optimization.

目的了解老化条件下义齿基托材料的性能对评估其临床性能和对口腔健康的影响至关重要。本研究评估了聚甲基丙烯酸甲酯（PMMA）、二甲基丙烯酸甲酯基聚合物（DMA）和聚醚醚酮（PEEK）义齿基托材料在老化（热、机械、化学）后的行为，基于参数（表面、机械、吸附、结构），并考虑了制造技术（自动固化、研磨、3D打印）。材料与方法采用PMMA（自动固化、铣削）、DMA （3D打印：90°/45°取向）、PEEK（铣削）五种义齿基托材料制作盘状标本（2mm × 8mm，每组n = 10，共n = 500）。采用标准化的粗糙或精细表面。标本进行了不同的老化方案：热循环、牙刷磨损、HCl/NaOCl储存。分析了时效前后的表面和材料性能。采用非参数检验对数据进行评价（Kruskal-Wallis, Mann-Whitney U, α = 0.05）。计算了效应量。结果与其他材料相比，老化后PEEK的表面参数、显微硬度和压痕变化不大。所有材料的吸水性和溶解度均表现出很强的效应大小（r≥0.85∗∗）。在PMMA中，老化显著降低了表面和机械性能，特别是在粗糙处理的样品中。与45°印刷相比，90°印刷的DMA受老化的影响较小，特别是经过精细处理后。经精细处理的磨粒PMMA在PMMA变型中表现出最高的抗老化性能。一般来说，粗糙的表面比精细的表面更容易老化。结论义齿基托材料的抗老化性能与表面处理、材料和制造工艺有关。适当的抛光可以减少表面和机械性能的老化效应。铣削产生可靠的结果，而3D打印需要进一步优化。

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引用次数: 0

Controlled microstructural evolution of Hydroxyapatite–Bioglass® nanocomposites via two-step sintering 两步烧结法制备羟基磷灰石-生物玻璃纳米复合材料

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-12-29 DOI: 10.1016/j.jmbbm.2025.107329

Mohamad Hassan Taherian , Thi Anh Le , Anh Van Thi Le , Dung My Thi Dang , Tin Chanh Duc Doan , Chien Mau Dang , Martin Bolduc

Hydroxyapatite (HA)–Bioglass® (45S) nanocomposites were fabricated via two-step sintering (TSS) to optimize densification, phase stability, and mechanical performance for potential bone regeneration applications. Composite nanopowders were prepared by a sol–gel route, compacted into pellets, and subjected to a TSS protocol with systematically varied temperatures and holding times. The selected two-step sintering (TSS2) parameters were identified as an initial temperature of 1150 °C with a 15 min hold, followed by a seconday treatment at 1050 °C for 25 h, which yielded the best balance of densification and phase stability. X-ray diffraction and scanning electron microscopy revealed that HA remained the primary phase, while β-tricalcium phosphate (β-TCP) formation increased with Bioglass® content, enhancing fracture toughness via crack-bridging and transformation-induced local compressive stresses. Bulk density and nanoindentation measurements showed that Bioglass® acted as an effective sintering aid, promoting densification and improving hardness, elastic modulus, and toughness. Among the studied compositions, the 10 wt% Bioglass® composite processed under selected TSS2 conditions exhibited the highest density and superior mechanical properties, while maintaining nanoscale grains (<100 nm). These results demonstrate that controlled TSS can effectively tailor the microstructure and performance of HA– Bioglass® composites, offering a promising strategy for advanced bioceramic implants.

羟基磷灰石(HA) -生物玻璃®（45S）纳米复合材料通过两步烧结（TSS）制备，以优化致密化，相稳定性和机械性能，用于潜在的骨再生应用。复合纳米粉末通过溶胶-凝胶途径制备，压实成颗粒，并在系统变化的温度和保温时间下进行TSS协议。选择的两步烧结（TSS2）参数为初始温度为1150°C，保温15分钟，然后在1050°C下进行第二次烧结，保温25小时，这可以获得致密化和相稳定性的最佳平衡。x射线衍射和扫描电镜显示，HA仍然是主要相，而β-磷酸三钙（β-TCP）的形成随着biglass®含量的增加而增加，通过裂缝桥接和转化引起的局部压应力增强了断裂韧性。体积密度和纳米压痕测量表明，生物玻璃®作为一种有效的烧结助剂，促进致密化，提高硬度、弹性模量和韧性。在所研究的组合物中，在选定的TSS2条件下加工的10 wt%生物玻璃®复合材料具有最高的密度和优异的力学性能，同时保持了纳米级颗粒（<100 nm）。这些结果表明，可控的TSS可以有效地定制HA -生物玻璃®复合材料的微观结构和性能，为先进的生物陶瓷植入物提供了一个有前途的策略。

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引用次数: 0

Tetrahedral microFE models of human trabecular bone can be a valid alternative to voxel-based hexahedral models: A comparative study using an open-source workflow 人类小梁骨的四面体微有限元模型可以是基于体素的六面体模型的有效替代：使用开源工作流程的比较研究

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-12-25 DOI: 10.1016/j.jmbbm.2025.107326

Giulia Fraterrigo , Alfonso Dario Santamaria , Gianluca Iori , Martino Pani , Gianluigi Crimi , Enrico Schileo , Fulvia Taddei

引用次数: 0