Journal of the Mechanical Behavior of Biomedical Materials最新文献_第7页

Relevance of mode mixity when contrasted with adhesion variability in dental restorations 模式混合的相关性，当对比粘连变异性在牙科修复。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-14 DOI: 10.1016/j.jmbbm.2025.107227

Yannick Yasothan , Mariam Diarra , Jan Neggers , Nicolas Schmitt , Johan Hoefnagels , Elsa Vennat

Dental repair treatments often involve a bonded ceramic prosthesis, where the bonded interface constitutes a weakness subjected to complex mechanical stresses, leading to mixed interface loading. In such cases, the mixed-mode interface properties are of interest in predicting the ultimate moment of failure, however, their characterization can be laborious. This paper shows that the influence of mode mixity is insignificant with respect to interface adhesion variability, even for interfaces created under laboratory conditions. This result is obtained from miniature mixed-mode bending tests on bonded dental assemblies with varying mode mixity. In situ microscopy images were used, in combination with digital image correlation, to measure the crack propagation, which plays a critical part in computing the interface toughness. Next, a full uncertainty analysis of all error sources provides an upper bound for the expected variability. In contrast, the influence of mode mixity was much smaller than the measured interface toughness variability leading to the conclusion that the actual interface has a spread in toughness which is likely due to surface roughness and chemical variations along the adhesion surface, instead of due to mode mixity. This interface variability is shown to be much larger than the influence of mode mixity, if present at all. Consequently, in the short term, mode mixity analyses have little impact in the understanding of these interfaces, allowing more attention to be given to the source of the interface variability.

牙科修复治疗通常涉及粘合陶瓷假体，其中粘合界面构成一个弱点，受到复杂的机械应力，导致混合界面加载。在这种情况下，混合模式界面特性对预测最终失效时刻很有意义，然而，它们的表征可能很费力。本文表明，模态混合对界面粘附变异性的影响是微不足道的，即使是在实验室条件下创建的界面。这一结果是通过对不同模态混合的粘结牙组件进行微型混合模弯曲试验得到的。利用原位显微图像，结合数字图像相关，测量裂纹扩展，这在计算界面韧性中起着至关重要的作用。接下来，对所有误差源进行全面的不确定性分析，为期望的可变性提供一个上限。相比之下，模态混合对界面韧性变化的影响要小得多，从而得出结论，实际界面的韧性是分散的，这可能是由于表面粗糙度和粘附表面的化学变化，而不是由于模态混合。如果存在的话，这种界面变异性比模态混合的影响要大得多。因此，在短期内，模态混合分析对理解这些界面影响不大，可以更多地关注界面变异性的来源。

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引用次数: 0

Nano-mechanical mapping of human and porcine abdominal aortic aneurysm 人与猪腹主动脉瘤的纳米机械成像。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-14 DOI: 10.1016/j.jmbbm.2025.107229

Aratrika Pan , Stevan Glisic , Blain Jones , Anna Debski , Arunark Kolipaka , Michael Go , Gunjan Agarwal

Abdominal aortic aneurysm (AAA) is characterized by extensive remodeling of the extracellular matrix. The propensity of AAA rupture is dependent on the macro as well as micro and nanoscale heterogeneity in its mechanical properties. Previous studies have shown that AAA tissue comprises of mechanically soft and stiff regions as compared to healthy tissue. However, the correlation of these heterogeneous mechanical properties to its structural components are not well characterized. In this study we used atomic force microscopy (AFM) to analyze human AAA tissue, extracted at the time of vascular surgery. In addition, healthy and diseased aortic tissue from a porcine model of AAA were examined. AFM was used to generate topographical images of tissue sections in a fluid environment, which were identified to be collagenous or non-collagenous regions. Quantitative Nanomechanical Mapping of the corresponding regions was performed to ascertain the local modulus. Transmission electron microscopy (TEM) and histological staining were used to localize calcific deposits. Our results indicate that AAA tissue is mechanically heterogenous with the modulus of collagenous regions being twice that of non-collagenous regions. The moduli of porcine AAA were comparable to that of human AAA and higher than healthy aorta from the corresponding animals. In addition, AAA tissue was interspersed with nanoscale particles of higher moduli, likely representing calcific deposits. The presence of calcific deposits was verified using TEM imaging and a dual histological staining approach consisting of Von Kossa and degraded collagen staining. We thus elucidate the nanoscale mechanical heterogeneity in AAA which can be attributed in part to collagen fibrils and calcific deposits.

腹主动脉瘤（AAA）的特征是细胞外基质的广泛重塑。AAA材料的断裂倾向不仅取决于其力学性能的宏观非均质性，还取决于其微观和纳米尺度的非均质性。先前的研究表明，与健康组织相比，AAA组织由机械柔软和僵硬的区域组成。然而，这些异质力学性能与其结构组分的相关性并没有很好地表征。在这项研究中，我们使用原子力显微镜（AFM）来分析在血管手术时提取的人类AAA组织。此外，还对猪AAA模型的健康和病变主动脉组织进行了检查。AFM用于在流体环境中生成组织切片的地形图像，这些图像被识别为胶原区或非胶原区。对相应区域进行了定量的纳米力学映射，以确定局部模量。透射电镜（TEM）和组织学染色用于定位钙化沉积。我们的结果表明，AAA组织具有机械异质性，胶原区域的模量是非胶原区域的两倍。猪主动脉的模量与人主动脉模量相当，且高于相应动物的健康主动脉模量。此外，AAA组织散布着高模量的纳米级颗粒，可能代表钙化沉积。通过TEM成像和Von Kossa染色和降解胶原染色的双重组织学染色方法证实了钙化沉积的存在。因此，我们阐明了AAA纳米尺度的力学异质性，这可以部分归因于胶原原纤维和钙化沉积。

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引用次数: 0

Segmental asymmetry and multiplanar motion of the lumbar spine: Cadaveric insights into spinal pathologies 腰椎节段性不对称和多平面运动：脊柱病理的尸体观察。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-13 DOI: 10.1016/j.jmbbm.2025.107230

Asghar Rezaei , Alexander Hooke , Babak Dashtdar , Areonna Schreiber , Abdelrahman M. Hamouda , Kai-Nan An , Benjamin Elder , Kenton Kaufman , Lichun Lu

The lumbar spine plays a critical role in supporting multiplanar motion and distributing loads during daily activities. While global spinal symmetry is often assumed in biomechanical assessments, segmental asymmetries may exist and contribute to conditions such as low back pain (LBP). The present study investigates the multiplanar kinematic behavior and torque asymmetry of the lumbar spine using cadaveric specimens, focusing on identifying segmental asymmetries that may be masked in global motion analysis. A novel experimental setup combining a 6°-of-freedom robotic system with optical metrology was used to apply controlled flexion-extension, lateral bending, and axial rotation to human lumbar spines. The metrology system enabled precise, non-contact tracking of vertebral motion in three dimensions, ensuring accurate quantification of segmental kinematics. Symmetrical motion inputs were applied bilaterally during lateral bending and axial rotation, while torque responses were recorded. Segmental range of motion (ROM) and torque asymmetries were quantified in the coronal and axial planes. Despite symmetrical inputs, torque outputs showed asymmetries exceeding 15 % in several specimens. Segmental ROM asymmetries were observed in most vertebrae, sometimes exceeding 40 %, and could vary across planes without consistent correlation. Notably, some spines exhibited segmental asymmetry despite overall torque symmetry, highlighting the limitations of global assessments. These findings underscore the importance of segment-level analysis in spinal biomechanics. Hidden asymmetries may have clinical implications for diagnosing and treating LBP. Spinal pathologies and alignment appear to partially account for subject-specific asymmetries in lateral bending and axial rotation.

腰椎在日常活动中起着支持多平面运动和分配负荷的关键作用。虽然在生物力学评估中通常假设脊柱整体对称，但节段性不对称可能存在，并导致腰痛（LBP）等疾病。本研究利用尸体标本研究腰椎的多平面运动行为和扭矩不对称性，重点是识别可能在全局运动分析中被掩盖的节段不对称性。将6°自由度机器人系统与光学测量相结合的新型实验装置用于控制人体腰椎的屈伸、侧向弯曲和轴向旋转。计量系统使精确的，非接触的椎体运动的跟踪在三维空间，确保准确的定量节段运动学。在横向弯曲和轴向旋转过程中，对称运动输入在两侧施加，同时记录扭矩响应。在冠状面和轴向面量化了节段运动范围（ROM）和扭矩不对称。尽管输入是对称的，但在一些试件中，扭矩输出的不对称性超过15%。在大多数椎骨中观察到节段性ROM不对称，有时超过40%，并且可能在各个平面上变化而没有一致的相关性。值得注意的是，尽管整体扭矩对称，但一些脊柱表现出节段不对称，这突出了整体评估的局限性。这些发现强调了脊柱生物力学中节段水平分析的重要性。隐性不对称可能对腰痛的诊断和治疗具有临床意义。脊柱病理和对齐似乎部分解释了受试者特异性不对称的侧弯和轴向旋转。

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引用次数: 0

Physics-Informed Neural Networks (PINNs) for solving the forward and inverse problems of prostate biomechanics 用于解决前列腺生物力学正反问题的物理信息神经网络（pinn）。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-11 DOI: 10.1016/j.jmbbm.2025.107225

María Ferrón-Vivó, Enrique Nadal, José Manuel Navarro-Jiménez, Santiago Gregori, María José Rupérez

This work introduces a novel integration of Physics-Informed Neural Networks (PINNs) with hyperelastic material modeling, employing the Neo-Hookean model to estimate the stiffness of soft tissue organs based on realistic anatomical geometries. Specifically, we propose the modeling of the prostate biomechanics as an initial application of this framework. By combining machine learning with principles of continuum mechanics, the methodology leverages finite element method (FEM) simulations and magnetic resonance imaging (MRI)-derived prostate models to address forward and inverse biomechanical problems. The PINN framework demonstrates the ability to provide accurate material property estimations, requiring limited data while overcoming challenges in data scarcity. This approach marks a significant advancement in patient-specific precision medicine, enabling improved diagnostics, personalized treatment planning, and broader applications in the biomechanical characterization of other soft tissues and organ systems.

这项工作引入了一种新的物理信息神经网络（pinn）与超弹性材料建模的集成，采用Neo-Hookean模型来估计基于真实解剖几何的软组织器官的刚度。具体来说，我们建议将前列腺生物力学建模作为该框架的初步应用。通过将机器学习与连续介质力学原理相结合，该方法利用有限元法（FEM）模拟和磁共振成像（MRI）衍生的前列腺模型来解决正向和反向生物力学问题。PINN框架展示了提供准确的材料属性估计的能力，需要有限的数据，同时克服了数据稀缺的挑战。这种方法标志着患者特异性精准医学的重大进步，使改进的诊断、个性化的治疗计划和更广泛的应用于其他软组织和器官系统的生物力学表征。

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引用次数: 0

Poro-viscoelastic mechanical characterization of healthy and osteoarthritic human articular cartilage 健康和患骨关节炎的人关节软骨的孔粘弹性力学特性。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-10 DOI: 10.1016/j.jmbbm.2025.107226

Jessica Faber , Alexander Greiner , Paula Büttner , Chiara Schoppe , Lars Bräuer , Friedrich Paulsen , Torsten Blunk , Mario Perl , Marcel Betsch , Silvia Budday

Articular cartilage serves an important mechanical function in the human body. For the design of implants for cartilage repair after injury or disease, it is key to thoroughly understand the unique mechanical properties of the native tissue. Here, we use multimodal mechanical testing combined with poro-viscoelastic modeling, finite element simulations, and histology to characterize the region-specific macroscopic large-strain mechanical properties of healthy and osteoarthritic human articular cartilage as well as their relation to the underlying microanatomy. We individually characterize tissue from medial and lateral sides, respectively, of the human femoral condyle and tibial plateau. Our results show that there are no significant differences between the medial and lateral sides, but tissue from the tibial plateau is slightly softer than tissue from the femoral condyle. Osteoarthritis leads to a significantly softened mechanical response, which correlates with corresponding microstructural changes. Through the presented combination of experiments and poro-viscoelastic material parameter identification for healthy and osteoarthritic cartilage, we confirm a reduction in stiffness and an increase in permeability due to the disease. The parameters can be valuable for future finite element simulations of the knee joint The presented results will help guide the design of implants that are able to restore cartilage structure and function, bridging biomechanics and regenerative medicine for osteoarthritis treatment.

关节软骨在人体中起着重要的机械作用。对于软骨损伤或疾病后修复植入物的设计，深入了解原生组织的独特力学特性是关键。在这里，我们使用多模态力学测试，结合孔隙粘弹性模型、有限元模拟和组织学来表征健康和骨关节炎患者关节软骨的区域特异性宏观大应变力学特性及其与底层显微解剖结构的关系。我们分别描述了人类股骨髁和胫骨平台内侧和外侧的组织。我们的结果显示，内侧和外侧之间没有显著差异，但胫骨平台的组织比股骨髁的组织稍软。骨关节炎导致机械反应明显软化，这与相应的微结构变化有关。通过对健康软骨和骨关节炎软骨的实验和孔粘弹性材料参数的识别，我们证实了疾病导致的刚度降低和通透性增加。这些参数对未来膝关节的有限元模拟具有重要价值。本文的结果将有助于指导能够恢复软骨结构和功能的植入物的设计，连接生物力学和骨关节炎治疗的再生医学。

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引用次数: 0

Shear-induced rotation mechanism of VWF A2 domain plays important role in mediating platelet adhesion VWF A2结构域的剪切诱导旋转机制在介导血小板粘附中起重要作用

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-10 DOI: 10.1016/j.jmbbm.2025.107224

Kuan-Yu Pan , Shu-Wei Chang

von Willebrand Factor (VWF) is a blood glycoprotein which plays an important role in mediating platelet adhesion to damaged blood vessel during hemostasis. It is known that the shear stress in blood stretches the A2 structural domain and regulates the platelet adhesion behavior through the cleavage by the metalloprotease ADAMTS13. The mechanical forces mediating the cleavage rate and the unfolding mechanism of A2 domain where the cleavage site (Tyr1605–Met1606 in β₄) resides is highly related to proper regulation of VWF proteolysis for maintaining normal hemostasis. Past studies have addressed the unfolding mechanism by conducting AFM experiments or SMD simulations. However, the local interaction of VWF with the surrounding fluid under shear flow were not considered, which might influence the unfolding pathway and the force required to facilitate the exposure of the cleavage site. Therefore, it's intriguing to study the unfolding pathway under shear flow at the molecular level to identify the conformational intermediates and force responses. In this study, we perform a molecular dynamics simulation with imposed shear flow on the VWF A2 domain to reveal how shear flow alters its molecular structure. Our results reveal that the loading condition strongly affects the molecular unfolding of VWF on its capability of rotation, which is crucial for stabilizing the βsheet and reducing the unfolding force under physiological condition. These findings provide fundamental knowledge for the development of future treatments of related diseases.

血管性血友病因子（VWF）是一种血糖糖蛋白，在止血过程中介导血小板粘附到受损血管中起重要作用。已知血液中的剪切应力拉伸A2结构域，并通过金属蛋白酶ADAMTS13的裂解调节血小板粘附行为。调节卵裂速率的机械力和卵裂位点（β4中的Tyr1605-Met1606）所在的A2结构域的展开机制与适当调节VWF蛋白水解以维持正常止血密切相关。过去的研究通过AFM实验或SMD模拟来解决展开机制。然而，在剪切流动下，未考虑VWF与周围流体的局部相互作用，这可能会影响展开路径和促进解理位点暴露所需的力。因此，在分子水平上研究剪切流作用下的展开途径，以识别构象中间体和力响应是很有意义的。在这项研究中，我们对VWF A2结构域进行了剪切流的分子动力学模拟，以揭示剪切流如何改变其分子结构。结果表明，加载条件对VWF分子展开的旋转能力有很大影响，而旋转能力对生理条件下稳定β片和减小展开力至关重要。这些发现为今后相关疾病的治疗提供了基础知识。

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引用次数: 0

Mechanical characterization of the equine linea alba and finite element modeling of suture patterns effects on its closure 马白线的力学特性及对缝合模式影响的有限元建模。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-10 DOI: 10.1016/j.jmbbm.2025.107228

Jellis Bollens , Lise Gheysen , Maria Verkade , Janne Stael , Ann Martens , Patrick Segers

Postoperative incisional complications are common in horses following abdominal surgery, which typically involves an incision through the abdominal wall along the linea alba. The linea alba is a fibrous band running in the craniocaudal direction along the ventral abdomen. This incision is closed with sutures, where the choice of suture pattern and surgical technique has shown to influence the rate of complications.

Therefore, this study investigated how different suture patterns and variations influence the stresses in the tissue by combining experimental and computational biomechanics. The mechanical properties of the equine linea alba were first characterized using uniaxial tensile tests. The samples were loaded in either the longitudinal, craniocaudal, or the transversal, laterolateral, direction. Based on the resulting stress-strain data, the Gasser-Ogden-Holzapfel material model was calibrated. This material model was then applied to develop a finite element model of the sutured linea alba, using an interrupted suture pattern. By changing the bite size, the distance from the incision to the suture entry point in the tissue, and the step size, the distance between stitches, their effect on the maximum principal stresses was analyzed. Additionally, a continuous suture pattern was modeled for comparison with the interrupted pattern.

The tensile tests revealed stiffer behavior of the linea alba in the longitudinal direction compared to the transversal direction. An increase in bite and step size led to a rise in the maximum principal stresses, with bite size having the largest effect. Switching from an interrupted to a continuous pattern only slightly increased stresses.

术后切口并发症在腹部手术后的马中很常见，这通常涉及沿白线穿过腹壁的切口。白线是沿腹侧沿颅侧方向的纤维带。该切口用缝线闭合，缝线模式和手术技术的选择影响了并发症的发生率。因此，本研究通过实验和计算生物力学相结合的方法研究了不同缝合方式和变化对组织内应力的影响。首先用单轴拉伸试验表征了马白线的力学性能。样品加载在纵向，颅侧，或横向，外侧，方向。基于得到的应力应变数据，对Gasser-Ogden-Holzapfel材料模型进行了校准。然后应用该材料模型建立缝合后白线的有限元模型，采用中断缝合模式。通过改变咬口大小、切口到组织缝线入口点的距离、步长、缝线之间的距离，分析它们对最大主应力的影响。此外，连续缝合模式建模与间断缝合模式进行比较。拉伸试验显示，与横向相比，白线在纵向上的刚度更大。咬合和步长的增加导致最大主应力的增加，其中咬合尺寸的影响最大。从中断模式切换到连续模式只会轻微增加压力。

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引用次数: 0

Biomechanical evaluation of shape-optimized CAD/CAM magnesium plates for mandibular reconstruction 形状优化CAD/CAM镁板下颌骨重建的生物力学评价

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107222

Philipp Ruf , Kilian Richthofer , Vincenzo Orassi , Claudius Steffen , Georg N. Duda , Max Heiland , Sara Checa , Carsten Rendenbach

Magnesium CAD/CAM miniplates are a promising alternative to titanium plates for mandibular reconstruction. However, gas formation is an inherent part of the magnesium degradation process, and thus, the quantity of magnesium used in fixation scenarios should be limited. Previous studies described several strategies to limit material volume, such as plate thickness reduction and shape-optimization. In particular, shape-optimization has been described as a strategy to limit material volume while maintaining mechanical integrity.

In consequence, the present study compared a shape-optimized CAD/CAM magnesium miniplate with standard CAD/CAM magnesium miniplates of varying thicknesses using a biomechanical finite element model. A single-segment mandibular reconstruction was chosen as the investigative scenario, evaluated under different biting tasks to assess the different plate shapes.

The shape-optimized magnesium plate demonstrated similar primary fixation stability compared to standard CAD/CAM magnesium miniplates, despite having reduced plate material and surface area. Shape optimization could help minimize magnesium volume and surface area to mitigate the issue of gas formation during the degradation process in vivo while maintaining biomechanical performance comparable to common CAD/CAM miniplates.

镁CAD/CAM微型钢板是一种很有前途的下颌重建钛板替代品。然而，气体的形成是镁降解过程的固有部分，因此，在固定场景中使用的镁的数量应该受到限制。先前的研究描述了几种限制材料体积的策略，如板厚度减少和形状优化。特别是，形状优化被描述为一种在保持机械完整性的同时限制材料体积的策略。因此，本研究使用生物力学有限元模型将形状优化的CAD/CAM微型镁板与不同厚度的标准CAD/CAM微型镁板进行了比较。选择单节段下颌骨重建作为研究场景，在不同的咬合任务下评估不同的钢板形状。与标准CAD/CAM镁微型板相比，形状优化的镁板显示出相似的初级固定稳定性，尽管减少了板材料和表面积。形状优化可以帮助减少镁的体积和表面积，以减轻体内降解过程中气体形成的问题，同时保持与普通CAD/CAM微型板相当的生物力学性能。

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引用次数: 0

A review of strategies for improving the mechanical properties of 3D bioprinted skin grafts 改善生物3D打印皮肤移植物机械性能的策略综述。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107223

Zhongxuan Shi , Hao Lv , Yu Wang , Danyang Zhao , Dong Han

As the largest organ of the human body, the skin serves as a crucial protective barrier against external damage. While traditional approaches to skin injury treatment increasingly struggle to meet clinical demands, three-dimensional (3D) bioprinting has emerged as an innovative approach for tissue-engineered skin regeneration. Nevertheless, challenges persist regarding the mechanical integrity of bioprinted constructs, particularly post-printing graft shrinkage. This review systematically examines three key strategies for enhancing the mechanical properties of 3D bioprinted skin grafts: (i) Biomaterial innovation through novel material development and composite systems that substantially improve structural stability; (ii) Advanced structural design incorporating bioinspired architectures, topological optimization, and gradient configurations to achieve biomimetic mechanical performance; (iii) Post-fabrication processing techniques involving novel crosslinking methods and parameter modulation to reinforce mechanical strength. By critically analyzing these synergistic enhancement strategies, this work establishes a conceptual framework to guide future research in developing clinically viable 3D bioprinted skin substitutes with optimal biomechanical functionality.

作为人体最大的器官，皮肤是抵御外界伤害的重要保护屏障。虽然传统的皮肤损伤治疗方法越来越难以满足临床需求，但三维（3D）生物打印已经成为组织工程皮肤再生的一种创新方法。然而，关于生物打印结构的机械完整性，特别是打印后移植物收缩方面的挑战仍然存在。本综述系统地研究了增强生物3D打印皮肤移植物机械性能的三个关键策略：(i)通过新型材料开发和复合系统进行生物材料创新，从而大大提高结构稳定性；（ii）先进的结构设计，结合仿生建筑，拓扑优化和梯度配置，以实现仿生机械性能；（iii）涉及新型交联方法和参数调制的后期加工技术，以增强机械强度。通过批判性地分析这些协同增强策略，本工作建立了一个概念框架，以指导未来开发具有最佳生物力学功能的临床可行的3D生物打印皮肤替代品的研究。

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引用次数: 0

Increasing the fatigue strength of laser-powder bed fusion manufactured Ti6Al4V hip stems by means of appropriate post-treatments 通过适当的后处理提高激光粉末床熔合Ti6Al4V髋骨的疲劳强度。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107221

Stefan Schroeder , Jens Gibmeier , Phuong Thao Mai , Maximilian C.M. Fischer , Moritz M. Innmann , Tobias Renkawitz , J. Philippe Kretzer

Due to the lower fatigue resistance of LPBF manufactured Ti6Al4V alloy compared to wrought material, hip stems are still manufactured conventionally, despite the advantages of patient-specific joint replacements. Therefore, the aim of the study was the investigation of appropriate post-treatments to increase the fatigue resistance of LPBF manufactured Ti6Al4V alloy using a four-point bending setup and a Locati-test. The results showed that only a combination of a hot isostatic pressing process and a sufficient surface treatment can lead to similar fatigue results as wrought material. Thereby, machining, deep rolling and shot peening turned out to be suitable surface treatments. For complex geometries like hip stems, shot peening is the most sufficient surface treatment. A combined surface treatment of shot peening and polishing led to similar fatigue results as the shot peening process alone. It can be followed that a combination of shot peening with a previous hot isostatic pressing process leads to satisfying fatigue results comparable to the wrought material and can be applied on complex geometries like hip stems. In addition, shoulder and neck area of a hip stem can be polished after the HIP process and the shot peening procedure without any reduction in fatigue strength.

由于与变形材料相比，LPBF制造的Ti6Al4V合金的抗疲劳性较低，尽管患者特定关节置换术具有优势，但仍采用传统方法制造髋关节干。因此，本研究的目的是研究适当的后处理，以提高LPBF制造的Ti6Al4V合金的抗疲劳性能，使用四点弯曲装置和定位试验。结果表明，只有热等静压工艺和充分的表面处理相结合才能产生与变形材料相似的疲劳结果。因此，机械加工、深滚和喷丸处理是合适的表面处理方法。对于复杂的几何形状，如髋杆，喷丸强化是最充分的表面处理。喷丸强化和抛光相结合的表面处理与单独喷丸强化处理产生的疲劳效果相似。由此可以看出，喷丸强化与先前的热等静压工艺相结合，可以产生与锻造材料相当的令人满意的疲劳结果，并且可以应用于复杂的几何形状，如髋杆。此外，髋关节茎的肩部和颈部区域可以在hip工艺和喷丸强化程序后抛光，而不会降低疲劳强度。

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引用次数: 0