Journal of the Mechanical Behavior of Biomedical Materials最新文献_第7页

Mechanical characterization of the equine linea alba and finite element modeling of suture patterns effects on its closure 马白线的力学特性及对缝合模式影响的有限元建模。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-10 DOI: 10.1016/j.jmbbm.2025.107228

Jellis Bollens , Lise Gheysen , Maria Verkade , Janne Stael , Ann Martens , Patrick Segers

Postoperative incisional complications are common in horses following abdominal surgery, which typically involves an incision through the abdominal wall along the linea alba. The linea alba is a fibrous band running in the craniocaudal direction along the ventral abdomen. This incision is closed with sutures, where the choice of suture pattern and surgical technique has shown to influence the rate of complications.

Therefore, this study investigated how different suture patterns and variations influence the stresses in the tissue by combining experimental and computational biomechanics. The mechanical properties of the equine linea alba were first characterized using uniaxial tensile tests. The samples were loaded in either the longitudinal, craniocaudal, or the transversal, laterolateral, direction. Based on the resulting stress-strain data, the Gasser-Ogden-Holzapfel material model was calibrated. This material model was then applied to develop a finite element model of the sutured linea alba, using an interrupted suture pattern. By changing the bite size, the distance from the incision to the suture entry point in the tissue, and the step size, the distance between stitches, their effect on the maximum principal stresses was analyzed. Additionally, a continuous suture pattern was modeled for comparison with the interrupted pattern.

The tensile tests revealed stiffer behavior of the linea alba in the longitudinal direction compared to the transversal direction. An increase in bite and step size led to a rise in the maximum principal stresses, with bite size having the largest effect. Switching from an interrupted to a continuous pattern only slightly increased stresses.

术后切口并发症在腹部手术后的马中很常见，这通常涉及沿白线穿过腹壁的切口。白线是沿腹侧沿颅侧方向的纤维带。该切口用缝线闭合，缝线模式和手术技术的选择影响了并发症的发生率。因此，本研究通过实验和计算生物力学相结合的方法研究了不同缝合方式和变化对组织内应力的影响。首先用单轴拉伸试验表征了马白线的力学性能。样品加载在纵向，颅侧，或横向，外侧，方向。基于得到的应力应变数据，对Gasser-Ogden-Holzapfel材料模型进行了校准。然后应用该材料模型建立缝合后白线的有限元模型，采用中断缝合模式。通过改变咬口大小、切口到组织缝线入口点的距离、步长、缝线之间的距离，分析它们对最大主应力的影响。此外，连续缝合模式建模与间断缝合模式进行比较。拉伸试验显示，与横向相比，白线在纵向上的刚度更大。咬合和步长的增加导致最大主应力的增加，其中咬合尺寸的影响最大。从中断模式切换到连续模式只会轻微增加压力。

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引用次数: 0

Biomechanical evaluation of shape-optimized CAD/CAM magnesium plates for mandibular reconstruction 形状优化CAD/CAM镁板下颌骨重建的生物力学评价

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107222

Philipp Ruf , Kilian Richthofer , Vincenzo Orassi , Claudius Steffen , Georg N. Duda , Max Heiland , Sara Checa , Carsten Rendenbach

Magnesium CAD/CAM miniplates are a promising alternative to titanium plates for mandibular reconstruction. However, gas formation is an inherent part of the magnesium degradation process, and thus, the quantity of magnesium used in fixation scenarios should be limited. Previous studies described several strategies to limit material volume, such as plate thickness reduction and shape-optimization. In particular, shape-optimization has been described as a strategy to limit material volume while maintaining mechanical integrity.

In consequence, the present study compared a shape-optimized CAD/CAM magnesium miniplate with standard CAD/CAM magnesium miniplates of varying thicknesses using a biomechanical finite element model. A single-segment mandibular reconstruction was chosen as the investigative scenario, evaluated under different biting tasks to assess the different plate shapes.

The shape-optimized magnesium plate demonstrated similar primary fixation stability compared to standard CAD/CAM magnesium miniplates, despite having reduced plate material and surface area. Shape optimization could help minimize magnesium volume and surface area to mitigate the issue of gas formation during the degradation process in vivo while maintaining biomechanical performance comparable to common CAD/CAM miniplates.

镁CAD/CAM微型钢板是一种很有前途的下颌重建钛板替代品。然而，气体的形成是镁降解过程的固有部分，因此，在固定场景中使用的镁的数量应该受到限制。先前的研究描述了几种限制材料体积的策略，如板厚度减少和形状优化。特别是，形状优化被描述为一种在保持机械完整性的同时限制材料体积的策略。因此，本研究使用生物力学有限元模型将形状优化的CAD/CAM微型镁板与不同厚度的标准CAD/CAM微型镁板进行了比较。选择单节段下颌骨重建作为研究场景，在不同的咬合任务下评估不同的钢板形状。与标准CAD/CAM镁微型板相比，形状优化的镁板显示出相似的初级固定稳定性，尽管减少了板材料和表面积。形状优化可以帮助减少镁的体积和表面积，以减轻体内降解过程中气体形成的问题，同时保持与普通CAD/CAM微型板相当的生物力学性能。

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引用次数: 0

A review of strategies for improving the mechanical properties of 3D bioprinted skin grafts 改善生物3D打印皮肤移植物机械性能的策略综述。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107223

Zhongxuan Shi , Hao Lv , Yu Wang , Danyang Zhao , Dong Han

As the largest organ of the human body, the skin serves as a crucial protective barrier against external damage. While traditional approaches to skin injury treatment increasingly struggle to meet clinical demands, three-dimensional (3D) bioprinting has emerged as an innovative approach for tissue-engineered skin regeneration. Nevertheless, challenges persist regarding the mechanical integrity of bioprinted constructs, particularly post-printing graft shrinkage. This review systematically examines three key strategies for enhancing the mechanical properties of 3D bioprinted skin grafts: (i) Biomaterial innovation through novel material development and composite systems that substantially improve structural stability; (ii) Advanced structural design incorporating bioinspired architectures, topological optimization, and gradient configurations to achieve biomimetic mechanical performance; (iii) Post-fabrication processing techniques involving novel crosslinking methods and parameter modulation to reinforce mechanical strength. By critically analyzing these synergistic enhancement strategies, this work establishes a conceptual framework to guide future research in developing clinically viable 3D bioprinted skin substitutes with optimal biomechanical functionality.

作为人体最大的器官，皮肤是抵御外界伤害的重要保护屏障。虽然传统的皮肤损伤治疗方法越来越难以满足临床需求，但三维（3D）生物打印已经成为组织工程皮肤再生的一种创新方法。然而，关于生物打印结构的机械完整性，特别是打印后移植物收缩方面的挑战仍然存在。本综述系统地研究了增强生物3D打印皮肤移植物机械性能的三个关键策略：(i)通过新型材料开发和复合系统进行生物材料创新，从而大大提高结构稳定性；（ii）先进的结构设计，结合仿生建筑，拓扑优化和梯度配置，以实现仿生机械性能；（iii）涉及新型交联方法和参数调制的后期加工技术，以增强机械强度。通过批判性地分析这些协同增强策略，本工作建立了一个概念框架，以指导未来开发具有最佳生物力学功能的临床可行的3D生物打印皮肤替代品的研究。

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引用次数: 0

Increasing the fatigue strength of laser-powder bed fusion manufactured Ti6Al4V hip stems by means of appropriate post-treatments 通过适当的后处理提高激光粉末床熔合Ti6Al4V髋骨的疲劳强度。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107221

Stefan Schroeder , Jens Gibmeier , Phuong Thao Mai , Maximilian C.M. Fischer , Moritz M. Innmann , Tobias Renkawitz , J. Philippe Kretzer

Due to the lower fatigue resistance of LPBF manufactured Ti6Al4V alloy compared to wrought material, hip stems are still manufactured conventionally, despite the advantages of patient-specific joint replacements. Therefore, the aim of the study was the investigation of appropriate post-treatments to increase the fatigue resistance of LPBF manufactured Ti6Al4V alloy using a four-point bending setup and a Locati-test. The results showed that only a combination of a hot isostatic pressing process and a sufficient surface treatment can lead to similar fatigue results as wrought material. Thereby, machining, deep rolling and shot peening turned out to be suitable surface treatments. For complex geometries like hip stems, shot peening is the most sufficient surface treatment. A combined surface treatment of shot peening and polishing led to similar fatigue results as the shot peening process alone. It can be followed that a combination of shot peening with a previous hot isostatic pressing process leads to satisfying fatigue results comparable to the wrought material and can be applied on complex geometries like hip stems. In addition, shoulder and neck area of a hip stem can be polished after the HIP process and the shot peening procedure without any reduction in fatigue strength.

由于与变形材料相比，LPBF制造的Ti6Al4V合金的抗疲劳性较低，尽管患者特定关节置换术具有优势，但仍采用传统方法制造髋关节干。因此，本研究的目的是研究适当的后处理，以提高LPBF制造的Ti6Al4V合金的抗疲劳性能，使用四点弯曲装置和定位试验。结果表明，只有热等静压工艺和充分的表面处理相结合才能产生与变形材料相似的疲劳结果。因此，机械加工、深滚和喷丸处理是合适的表面处理方法。对于复杂的几何形状，如髋杆，喷丸强化是最充分的表面处理。喷丸强化和抛光相结合的表面处理与单独喷丸强化处理产生的疲劳效果相似。由此可以看出，喷丸强化与先前的热等静压工艺相结合，可以产生与锻造材料相当的令人满意的疲劳结果，并且可以应用于复杂的几何形状，如髋杆。此外，髋关节茎的肩部和颈部区域可以在hip工艺和喷丸强化程序后抛光，而不会降低疲劳强度。

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引用次数: 0

Shaping the mechanical properties of a gelatin hydrogel interface via amination 通过胺化形成明胶水凝胶界面的机械性能

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-01 DOI: 10.1016/j.jmbbm.2025.107219

Génesis Ríos Adorno , Kyle B. Timmer , Raul A. Sun Han Chang , Jiachun Shi , Simon A. Rogers , Brendan A.C. Harley

Injuries to musculoskeletal interfaces, such as the tendon-to-bone insertion of the rotator cuff, present significant physiological and clinical challenges for repair due to complex gradients of structure, composition, and cellularity. Advances in interface tissue engineering require stratified biomaterials able to both provide local instructive signals to support multiple tissue phenotypes while also reducing the risk of strain concentrations and failure at the transition between dissimilar materials. Here, we describe adaptation of a thiolated gelatin (Gel-SH) hydrogel via selective amination of carboxylic acid subunits on the gelatin backbone. The magnitude and kinetics of HRP-mediated primary crosslinking and carbodiimide-mediated secondary crosslinking reactions can be tuned through amination and thiolation of carboxylic acid subunits on the gelatin backbone. We also show that a stratified biomaterial comprised of mineralized (bone-mimetic) and non-mineralized (tendon-mimetic) collagen scaffold compartments linked by an aminated Gel-SH hydrogel demonstrate improved mechanical performance and reduced strain concentrations. Together, these results highlight significant mechanical advantages that can be derived from modifying the gelatin macromer via controlled amination and thiolation and suggest an avenue for tuning the mechanical performance of hydrogel interfaces within stratified biomaterials.

肌肉骨骼界面损伤，如肩袖的肌腱-骨插入，由于结构、组成和细胞结构的复杂梯度，对修复提出了重大的生理和临床挑战。界面组织工程的进展需要分层的生物材料，既能提供局部指导信号，支持多种组织表型，又能降低应变浓度和不同材料之间过渡失败的风险。在这里，我们描述了适应巯基明胶（凝胶- sh）水凝胶通过选择性胺化羧酸亚基上的明胶主链。通过明胶骨架上羧酸亚基的胺化和巯基化，可以调节酶介导的一级交联和碳二亚胺介导的二级交联反应的强度和动力学。我们还表明，由氨基化凝胶- sh水凝胶连接的矿化（模拟骨）和非矿化（模拟肌腱）胶原支架室组成的分层生物材料可以改善机械性能并降低应变浓度。总之，这些结果强调了通过控制胺化和硫代化修饰明胶大分子可以获得的显著机械优势，并为调整分层生物材料中水凝胶界面的机械性能提供了一条途径。

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引用次数: 0

Simulated oral environment affects zirconia aging and mechanical strength 模拟口腔环境影响氧化锆老化和机械强度

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-01 DOI: 10.1016/j.jmbbm.2025.107217

Danyal A. Siddiqui , Smriti G. Natarajan , Bhuvana Lakkasetter Chandrashekar , Danieli C. Rodrigues

Background

Zirconia is an emerging alternative to titanium for dental implant systems. However, zirconia surfaces can deteriorate under aqueous conditions, thereby compromising mechanical performance. The goal of this study was to assess the impact of biological exposure or aging simulating the oral cavity on the surface integrity and mechanical strength of surface-treated zirconia.

Methods

Partially yttria- or magnesia-stabilized zirconia specimens were polished, acid-etched, or sandblasted. Zirconia disks were exposed to mammalian cells or bacteria. Surface degradation via tetragonal-to-monoclinic phase transformation was assessed by Raman microscopy. Zirconia bars were subjected to accelerated aging by exposure to autoclave steam. Surface morphology was examined by scanning electron microscopy, and mechanical strength was measured using four-point bend test loading until failure.

Results

Early-colonizing oral bacteria significantly increased monoclinic content ∼5-fold on acid-etched yttria-stabilized zirconia versus control (p < 0.05). Surface monoclinic content on acid-etched zirconia increased rapidly (54.6 ± 9.3 %) after 4 h of aging before plateauing (77.0 ± 5.7 %) after 20 h. In contrast, polished or sandblasted zirconia exhibited minimal monoclinic content (∼4 %) after 4 h that gradually increased to ∼40 % by 20 h. Acid-etching treatment significantly reduced the flexural strength of zirconia (585 ± 34 MPa) while sandblasting variants were statistically similar (922 ± 52 MPa) to machined control (921 ± 74 MPa). Aging reduced the flexural strength of machined or sandblasted zirconia, which was significant (p < 0.05) for machined zirconia (782 ± 178 MPa).

Conclusions

Acid-etching and/or exposure to acidic environment increase zirconia susceptibility to surface degradation, impacting its surface and mechanical properties.

背景氧化锆是牙科种植体系统中钛的新兴替代品。然而，氧化锆表面在水环境下会变质，从而影响机械性能。本研究的目的是评估生物暴露或模拟口腔老化对表面处理氧化锆表面完整性和机械强度的影响。方法对部分氧化钇或镁稳定的氧化锆试样进行抛光、酸蚀或喷砂处理。氧化锆盘暴露于哺乳动物细胞或细菌中。通过拉曼显微镜评估四方到单斜相变的表面降解。氧化锆棒暴露在高压灭菌器蒸汽中加速老化。通过扫描电子显微镜检查表面形貌，并使用四点弯曲试验加载直至失效来测量机械强度。结果与对照组相比，早期定植的口腔细菌在酸蚀钇稳定氧化锆上的单斜晶含量显著增加约5倍（p < 0.05）。酸蚀氧化锆的表面单斜含量在时效4小时后迅速增加（54.6±9.3%），而在20小时后镀平（77.0±5.7%）。相比之下，抛光或喷砂氧化锆的表面单斜含量在4小时后最低（~ 4%），在20小时后逐渐增加到~ 40%。酸蚀处理显著降低了氧化锆的抗弯强度（585±34 MPa），而喷砂处理的变化与加工控制（921±74 MPa）相似（922±52 MPa）。老化降低了机械氧化锆和喷砂氧化锆的抗弯强度，其中机械氧化锆的抗弯强度显著降低（p < 0.05）（782±178 MPa）。结论酸蚀和/或暴露于酸性环境中会增加氧化锆的表面降解敏感性，影响其表面和力学性能。

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引用次数: 0

Characterization of the fatigue threshold behavior of UHMWPE 超高分子量聚乙烯的疲劳阈值行为表征。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-10-01 DOI: 10.1016/j.jmbbm.2025.107220

Bethany B. Smith , Anurag Roy , Robert O. Ritchie , Lisa A. Pruitt

Ultra-high-molecular-weight-polyethylene (UHMWPE) has been the material of choice for bearings in total joint replacements (TJRs) for decades as a result of its excellent wear resistance, chemical inertness, energetic toughness, low friction, and biocompatibility. Utilization of this polymer in orthopedic devices requires oxidation, wear, and fatigue resistance. Balancing these important properties by tailoring processing techniques and modulating microstructural features has been an ongoing endeavor in the field. Research into the clinical applications of UHMWPE has primarily focused on the challenges of wear and oxidation while studies into the realm of fatigue have been more limited. Literature gaps exist in fully understanding the fatigue crack initiation near notches or propagation of small existing flaws in UHMWPE used in TJRs. In particular, the characterization of the fatigue thresholds and near-threshold fatigue behavior of orthopedic grade UHMWPE has yet to be thoroughly explored. In this work, we characterized the fatigue crack arrest threshold of clinically-relevant UHMWPE formulations. Correlations between the fatigue thresholds and bulk mechanical properties as well as microstructural properties were examined across these medical resins. The important role played by crosslinking in influencing the fatigue performance of UHMWPE is highlighted in this study. In addition, it is established that J-integral fracture toughness is the best predictor of fatigue thresholds and could possibly be used as a stand-in metric for fatigue performance if thresholds cannot be directly ascertained. Finally, this study corroborates that the true constitutive parameters best describe the mechanical behavior of UHMWPE.

超高分子量聚乙烯（UHMWPE）由于其优异的耐磨性、化学惰性、能量韧性、低摩擦和生物相容性，几十年来一直是全关节置换术（TJRs）中轴承的首选材料。这种聚合物在骨科设备中的应用要求具有抗氧化、耐磨损和抗疲劳性能。通过定制加工技术和调制微观结构特征来平衡这些重要特性一直是该领域的持续努力。对超高分子量聚乙烯临床应用的研究主要集中在磨损和氧化方面，而对疲劳领域的研究则更为有限。在充分了解超高分子量聚乙烯在TJRs中存在的小缺陷在缺口附近的疲劳裂纹萌生或扩展方面存在文献空白。特别是，骨科级超高分子量聚乙烯的疲劳阈值和近阈值疲劳行为的表征还有待深入探讨。在这项工作中，我们表征了临床相关的超高分子量聚乙烯配方的疲劳裂纹止裂阈值。研究了这些医用树脂的疲劳阈值与体力学性能以及微观结构性能之间的相关性。本研究强调了交联对超高分子量聚乙烯疲劳性能的重要影响。此外，还确定了j积分断裂韧性是疲劳阈值的最佳预测指标，如果不能直接确定阈值，则可以将其用作疲劳性能的替代指标。最后，本研究证实了真实本构参数最能描述超高分子量聚乙烯的力学行为。

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引用次数: 0

Preparation and characterization of lithium disilicate glass-ceramics derived from sol-gel route with varied agitation speeds 溶胶-凝胶法制备不同搅拌速度的二硅酸锂微晶玻璃

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-09-30 DOI: 10.1016/j.jmbbm.2025.107218

Yaming Zhang , Xinyi Bai , Ding Li , Xi Liu , Xigeng Lyu , Fu Wang

Lithium disilicate (LD) glass-ceramics were fabricated through conventional sol-gel and pressureless sintering methods, with the influence of stirring speeds (200, 400, 600 and 1000 rpm) on their microstructural evolution, phase formation, and mechanical properties being systematically investigated. The variation in agitation speed significantly affected the agglomerated sizes and morphological characteristics of the gel-derived LD powers, which in true induced noticeable differences in phase compositions and crystallinities of both the precursor powers and the final glass-ceramics. These morphological variations directly correlated with the archived relative densities of the sintered LD glass-ceramics, and the mechanical property variations were also linked with the differing aspect ratios of the precipitated LD crystals within the microstructures. Optimal performance was obtained at the stirring speed of 400 rpm, yielding glass-ceramics with exceptional properties: highest relative density (94.01 ± 0.16 %), flexural strength (182.72 ± 1.5 MPa), hardness (3.84 ± 0.20 GPa), and fracture toughness (3.07 ± 0.17 MPa·m^1/2). These finding demonstrated that mechanical stirring parameters profoundly influenced the characteristics of gel-derived LD powders and resultant glass-ceramics, suggesting potential applicability of this process control strategy to other gel-derived lithium silicate materials, including Li₂SiO₃ and Li₄SiO₄.

采用溶胶-凝胶法和无压烧结法制备了二硅酸锂（LD）微晶玻璃，系统研究了搅拌速度（200、400、600和1000 rpm）对其显微组织演变、相形成和力学性能的影响。搅拌速度的变化显著影响了凝胶衍生LD粉体的团聚尺寸和形态特征，从而导致了前驱体粉体和最终微晶玻璃的相组成和结晶度的显著差异。这些形态变化与烧结LD微晶玻璃的相对密度直接相关，力学性能的变化也与微观结构中析出LD晶体的不同长宽比有关。在400 rpm的搅拌速度下获得最佳性能，得到的微晶玻璃具有优异的性能：最高的相对密度（94.01±0.16%）、抗弯强度（182.72±1.5 MPa）、硬度（3.84±0.20 GPa）和断裂韧性（3.07±0.17 MPa·m1/2）。这些发现表明，机械搅拌参数深刻地影响了凝胶衍生LD粉末和所得微晶玻璃的特性，表明该过程控制策略可能适用于其他凝胶衍生的硅酸锂材料，包括Li2SiO3和Li4SiO4。

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引用次数: 0

Mechanical properties of porous 3D-printed polycaprolactone: Experimental and numerical study 多孔3d打印聚己内酯的力学性能：实验和数值研究

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-09-30 DOI: 10.1016/j.jmbbm.2025.107216

Mohammad Hadi Yazdanpanah , Sadegh Rahmati , Shahrouz Yousefzadeh , Javad Akbari , Hormoz Nouraei

This study presents a systematic investigation into the porosity–strength relationships of 3D-printed polycaprolactone (PCL) to develop predictive models for the tensile behavior of porous structures intended for biomedical applications. The research investigates the impact of void geometry and porosity levels on the mechanical response under uniaxial tensile loading, utilizing Finite Element Method (FEM) simulations and Scanning Electron Microscopy (SEM) to elucidate stress distribution, plastic deformation, and fracture mechanisms. Three void geometries—circular, square, and triangular—were analyzed across porosity levels ranging from 6 % to 30 %. Circular voids demonstrated superior stress uniformity and deformation homogeneity, while square and triangular voids exhibited localized stress concentrations and earlier onset of plasticity. Increasing porosity resulted in a marked reduction in yield stress, with maximum decreases of 24 % in square voids, 23 % in triangular voids, and 15 % in circular voids. SEM analysis revealed manufacturing defects that significantly influenced deformation behavior. The adopted Elastic-Plastic numerical model showed strong agreement with experimental observations in terms of yielding force and ultimate force, presenting an error of less than 10 %. A statistical model was developed, achieving R-squared values exceeding 0.95, which enabled the reliable estimation of tensile properties within the studied porosity range. These findings offer critical insights into the mechanical optimization of porous PCL scaffolds, providing a robust framework for future design strategies in biomedical engineering.

本研究对3d打印聚己内酯（PCL）的孔隙率-强度关系进行了系统的研究，以开发用于生物医学应用的多孔结构拉伸行为的预测模型。该研究调查了孔隙几何形状和孔隙度水平对单轴拉伸载荷下力学响应的影响，利用有限元法（FEM）模拟和扫描电子显微镜（SEM）来阐明应力分布、塑性变形和断裂机制。研究人员分析了三种孔隙几何形状——圆形、方形和三角形，孔隙度从6%到30%不等。圆形孔洞表现出较好的应力均匀性和变形均匀性，而正方形和三角形孔洞表现出局部应力集中和较早的塑性。孔隙度的增加导致屈服应力显著降低，方形孔洞最大降低24%，三角形孔洞最大降低23%，圆形孔洞最大降低15%。扫描电镜分析表明，制造缺陷对变形行为有显著影响。所采用的弹塑性数值模型在屈服力和极限力方面与实验结果吻合较好，误差小于10%。建立了一个统计模型，其r平方值超过0.95，从而能够在研究的孔隙率范围内可靠地估计拉伸性能。这些发现为多孔PCL支架的力学优化提供了重要的见解，为生物医学工程的未来设计策略提供了一个强大的框架。

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引用次数: 0

Fused filament fabrication manufactured biological scaffolds: An investigation of mechanical properties by using the Taguchi method and machine learning techniques 熔融丝制备生物支架：利用田口法和机器学习技术研究其力学性能。

IF 3.5 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials

Pub Date : 2025-09-28 DOI: 10.1016/j.jmbbm.2025.107215

Idil Tartici , Paulo Bartolo

Tissue engineering scaffolds are three-dimensional, biocompatible, biodegradable, and porous structures designed to support cell attachment, proliferation, and differentiation, leading to new tissue formation. Designing optimal scaffolds is complex, requiring the optimisation of various physical, chemical, and biological properties, which are cell- or tissue-dependent. For hard tissue applications such as bone, compressive strength is a critical property and can be adjusted by modifying printing conditions. The mechanical properties of scaffolds produced using different microstructural polymers (semi-crystalline and amorphous) depend on parameters that significantly impact filament extrusion and the crystallisation process. This study investigates the effect of key process parameters (printing temperature, printing speed, and flow) on scaffold mechanical properties using the Taguchi method. Three biocompatible polymers with different microstructures—polycaprolactone, polylactic acid, and polyethylene terephthalate glycol—were examined. Results show a high correlation between process parameters and compressive strength using the Taguchi method, but prediction accuracy remained low. Therefore, four machine learning algorithms—Random Forest (RF), Support Vector Regression (SVR), K-Nearest Neighbor (K-NN), and Gradient Boosting Regression (GBR)—were applied to enhance predictive performance. Notably, the RF and GBR algorithms achieved approximately 99 % prediction accuracy when evaluated on the test dataset.

组织工程支架是三维的、生物相容性的、可生物降解的多孔结构，旨在支持细胞附着、增殖和分化，从而形成新的组织。设计最佳支架是复杂的，需要优化各种物理、化学和生物特性，这些特性是细胞或组织依赖的。对于硬组织的应用，如骨，抗压强度是一个关键的性质，可以通过修改打印条件进行调整。使用不同微观结构聚合物（半晶和非晶）生产的支架的机械性能取决于显著影响长丝挤压和结晶过程的参数。本研究采用田口法研究了关键工艺参数（打印温度、打印速度和流量）对支架力学性能的影响。研究了三种不同微观结构的生物相容性聚合物——聚己内酯、聚乳酸和聚对苯二甲酸乙二醇酯。结果表明，田口法的工艺参数与抗压强度具有较高的相关性，但预测精度较低。因此，四种机器学习算法——随机森林（RF）、支持向量回归（SVR）、k -最近邻（K-NN）和梯度增强回归（GBR）——被应用于提高预测性能。值得注意的是，当在测试数据集上进行评估时，RF和GBR算法达到了大约99%的预测精度。

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引用次数: 0