Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"Automatic adjustment of dental crowns using Laplacian mesh editing","authors":"Oliver Roffmann ,&nbsp;Meike Stiesch ,&nbsp;Christof Hurschler ,&nbsp;Andreas Greuling","doi":"10.1016/j.jmbbm.2024.106878","DOIUrl":"10.1016/j.jmbbm.2024.106878","url":null,"abstract":"<div><div>Currently, the restoration of missing teeth by means of dental implants is a common treatment method in dentistry. Ensuring optimal contact between teeth (occlusion) when designing the occlusal surface of an implant-supported crown is crucial for the patient. Although there are various occlusal concepts and guidelines for achieving optimised occlusion, adapting an occlusal surface is challenging. The contact points must be established in certain areas of the occlusal surface without impairing the aesthetics of the teeth and the masticatory function. A computer-aided, automated modelling approach can assist in the design process and can reduce the reliance on manual labour. This study aimed to develop a modelling approach that enables the automatic adaptation of an occlusal surface to specific occlusal concepts while preserving the natural appearance. In this study, the occlusal surface of an implant-supported crown based on a scanned first right mandibular molar was adopted. Nominal contact points were determined based on occlusal concepts by Ramfjord and Ash (RA) and Thomas (T). The shape of the occlusal surface was then adapted concerning the desired contact points using Laplacian mesh editing. The modification results were validated for different forces and crown materials (3Y-TZP and PMMA) using a finite element contact analysis. The contact analysis results showed that locations with high compressive stresses correspond with the locations of the nominal contact points. The reaction forces were more evenly distributed in PMMA crowns, due to the lower Young's modulus of PMMA compared to 3Y-TZP. Furthermore, the occlusal scheme with fewer contact points (RA) showed higher maximum reaction forces per contact area. The presented method enables the automated adaptation of an (implant-supported) crown to specific occlusal schemes, proving to be valuable in dental CAD.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106878"},"PeriodicalIF":3.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical characteristics of spinal cord tissue by indentation","authors":"Oskar Neumann ,&nbsp;Harsh Vardhan Surana ,&nbsp;Stephen Melly ,&nbsp;Paul Steinmann ,&nbsp;Silvia Budday","doi":"10.1016/j.jmbbm.2024.106863","DOIUrl":"10.1016/j.jmbbm.2024.106863","url":null,"abstract":"<div><div>The mechanical properties of brain and spinal cord tissue have proven to be extremely complex and difficult to assess. Due to the heterogeneous and ultra-soft nature of the tissue, the available literature shows a large variance in mechanical parameters derived from experiments. In this study, we performed a series of indentation experiments to systematically investigate the mechanical properties of porcine spinal cord tissue in terms of their sensitivity to indentation tip diameter, loading rate, holding time, ambient temperature along with cyclic and oscillatory dynamic loading. Our results show that spinal cord white matter tissue is more compliant than grey matter tissue with apparent moduli of 128.7 and 403.8 Pa, respectively. They show similar viscoelastic behavior with stress relaxation time constants of <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>1</mn></mrow></msub><mo>=</mo><mn>1</mn><mo>.</mo><mn>38</mn><mspace></mspace></mrow></math></span>s and <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>2</mn></mrow></msub><mo>=</mo><mn>36</mn><mo>.</mo><mn>29</mn><mspace></mspace></mrow></math></span>s for grey matter and <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>1</mn></mrow></msub><mo>=</mo><mn>1</mn><mo>.</mo><mn>46</mn><mspace></mspace></mrow></math></span>s and <span><math><mrow><msub><mrow><mi>τ</mi></mrow><mrow><mn>2</mn></mrow></msub><mo>=</mo><mn>46</mn><mo>.</mo><mn>10</mn><mspace></mspace></mrow></math></span>s for white matter, while the initial peak force decreased by 54 % for grey and 59 % for white matter tissue. An increase of the applied loading rate by two orders of magnitude led to an approximate doubling of the apparent modulus for both tissue types. Thermal variations showed a decrease in apparent modulus of up to 30 % after heating from 20 to 37.0 °C. Our dynamic tests revealed a significant influence of cyclic preload on the stiffness, with a drop of up to 20 % and a relative decrease of up to 60 % after the first cycle compared to the total modulus drop after five cycles for spinal cord grey matter tissue. Oscillatory indentation experiments identified similar loss moduli for spinal cord grey and white matter tissue and a higher storage modulus for white matter tissue. This work provides systematic insights into the mechanical properties of spinal cord tissue under different loading scenarios using nanoindentation.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106863"},"PeriodicalIF":3.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, additive manufacturing, and characterization of an organ-on-chip microfluidic device for oral mucosa analogue growth","authors":"Foteini Machla ,&nbsp;Paraskevi Kyriaki Monou ,&nbsp;Panagiotis Artemiou ,&nbsp;Ioannis Angelopoulos ,&nbsp;Vasileios Zisis ,&nbsp;Emmanuel Panteris ,&nbsp;Orestis Katsamenis ,&nbsp;Eric Williams ,&nbsp;Emmanouil Tzimtzimis ,&nbsp;Dimitrios Tzetzis ,&nbsp;Dimitrios Andreadis ,&nbsp;Alexander Tsouknidas ,&nbsp;Dimitrios Fatouros ,&nbsp;Athina Bakopoulou","doi":"10.1016/j.jmbbm.2024.106877","DOIUrl":"10.1016/j.jmbbm.2024.106877","url":null,"abstract":"<div><h3>Introduction</h3><div>Α customized organ-on-a-chip microfluidic device was developed for dynamic culture of oral mucosa equivalents (Oral_mucosa_chip-OMC).</div></div><div><h3>Materials and methods</h3><div>Additive Manufacturing (AM) was performed via stereolithography (SLA) printing. The dimensional accuracy was evaluated via microfocus computed tomography (mCT), the surface characteristics via scanning electron microscopy (SEM), while the mechanical properties via nanoindentation and compression tests. Computational fluid dynamics (CFD) optimized net forces towards the culture area. An oral mucosa equivalent comprising a multilayered epithelium derived by culture of TR146 cells at the air-liquid interface (ALI) and a lamina propria-analogue based on a collagen-I/fibrin hydrogel was maintained under ultra-precise flow conditions.</div></div><div><h3>Results</h3><div>An open-type device concept encompassing two interconnected chambers for long-term dynamic culture was developed and characterized for AM parameters, mechanical and biological properties. The split-inlet flow channel architecture allowed even distribution and symmetric flow velocity to the culture area. Cell viability exceeded 90%, while mCT and SEM indicated the 0° building angle as the most accurate SLA condition. CFD further showed that the 0° and 30° building angles most accurately reproduced the channel flow velocity predicted by the initial CAD model.</div></div><div><h3>Conclusion</h3><div>This study developed a customized, easy-to-produce, and cell-friendly OMC device, providing a 3D tool for biocompatibility assessment of biomaterials.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106877"},"PeriodicalIF":3.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive methodology to assess human bone transversal toughness based on macroscopic specimens, the compliance method, and 3D bio-faithful numerical simulations","authors":"T. Kurtz ,&nbsp;Y. Godio-Raboutet ,&nbsp;F.L.B. Ribeiro ,&nbsp;J.-L. Tailhan","doi":"10.1016/j.jmbbm.2024.106869","DOIUrl":"10.1016/j.jmbbm.2024.106869","url":null,"abstract":"<div><div>This study proposes a method for assessing the transverse toughness of human long-bone cortical tissue. The method is based on a three-point bending test of pre-notched femur diaphysis segments, post-processed using the compliance method coupled with numerical simulations. Given the cracking nature of bone and if cracking processes remain confined to the crack tip, it is assumed that the compliance method can be used. Numerical simulations are based on a bio-faithful 3D reconstruction of the bones tested and a detailed consideration of the boundary and loading conditions of the mechanical test. The resulting toughness values obtained on embalmed bones range from <span><math><msub><mrow><mi>G</mi></mrow><mrow><mi>c</mi></mrow></msub></math></span>=4.3 to 7.1 N/mm. The assumptions made, the biofidelity of the simulations, and the ability of the method to determine an intrinsic toughness value of cortical bone, considered a heterogeneous material, are discussed. Although related to embalmed bones, and considering the limitations this state can induce, the toughness values obtained are consistent with data from the literature. Due to the larger specimen size, they are also more realistic, ensuring a complete description of the material’s crack extension resistance curve. They mainly characterize the medial and lateral quadrants of the bone transversal section. The study concludes that the proposed method provides a robust approach for assessing bone transversal toughness.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106869"},"PeriodicalIF":3.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The human patellar tendon is mechanically homogenous at its mid-substance","authors":"Adam Kositsky ,&nbsp;Lauri Stenroth ,&nbsp;Ervin Nippolainen ,&nbsp;Jari Torniainen ,&nbsp;Janne T.A. Mäkelä ,&nbsp;Petri Paakkari ,&nbsp;Tommi Paakkonen ,&nbsp;Heikki Kröger ,&nbsp;Juha Töyräs ,&nbsp;Isaac O. Afara ,&nbsp;Rami K. Korhonen","doi":"10.1016/j.jmbbm.2024.106875","DOIUrl":"10.1016/j.jmbbm.2024.106875","url":null,"abstract":"<div><div>The human patellar tendon contains distinct fascicle bundles across its mediolateral and anteroposterior regions. Studies have suggested region-specific behaviour during <em>in vivo</em> actions, but it is unclear whether such regional differences result from localized variation in composition and mechanical properties within the tendon itself. Furthermore, the viscoelastic properties of any region of the human patellar tendon have not been well described previously. Here, a comprehensive investigation of the composition and material properties of six regions (three mediolateral × two anteroposterior) of the human patellar tendon was performed on tendons harvested from eight cadaver knees. Thorough viscoelastic (stress relaxation and sinusoidal) and elastic (failure) mechanical tests were conducted on dumbbell-shaped samples. Uronic acid (proteoglycan), hydroxyproline (collagen), and water contents were measured from the samples after mechanical testing. No systematic between-region differences were found for any measured biomechanical or biochemical parameter. However, the phase difference between stress and strain decreased as a function of increasing sinusoidal frequency (from 0.1 Hz to 5 Hz), suggesting the human patellar tendon behaves more elastically at higher strain rates. These results indicate the human patellar tendon is a homogenous material at its mid-substance and that other factors, such as geometrical constraints, enthesis properties, and insertion points, may be responsible for any region-specific behaviour <em>in vivo</em>. Additionally, the more elastic behaviour of the human patellar tendon as strain rate increases likely supports improved joint control and enhanced movement economy during fast actions such as sprinting.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106875"},"PeriodicalIF":3.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical behavior of cantilevered 3-unit implant-supported prostheses made of PEKK and monolithic zirconia: A finite element study","authors":"Hatem S. Sadek ,&nbsp;Noha M. Anany ,&nbsp;Mohamed I. El-Anwar ,&nbsp;Abdulaziz Alhotan ,&nbsp;Al-Hassan Diab ,&nbsp;Mostafa Aldesoki ,&nbsp;Tarek M. Elshazly ,&nbsp;Christoph Bourauel","doi":"10.1016/j.jmbbm.2024.106872","DOIUrl":"10.1016/j.jmbbm.2024.106872","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the biomechanical performance of various designs of cantilevered three-unit implant-supported prostheses, using two distinct prosthetic materials and under different loading conditions.</div></div><div><h3>Method</h3><div>Three mandibular models were created with varying implant positions to support a 3-unit prosthesis using two materials (Zirconia and PEKK), resulting in three different designs: distal cantilever (M1), fixed-fixed (M2), and mesial cantilever (M3). The geometric model was created by segmenting a CBCT scan of an edentulous mandible using Mimics software, followed by refinement in 3-Matic to generate a trabecular bone core encased by a 2 mm-thick cortical shell and a 1 mm-thick mucosal layer. Implant CAD files were integrated, and the models were processed in SolidWorks to finalize solid geometries. These were then imported into ANSYS for mesh generation and finite element analysis, with materials assumed to be isotropic and elastic. Models underwent 3 different static loading protocols (Vertical 100 N, 30° Oblique 50 N, 45° Oblique 50 N). Von Mises stress and total deformation were calculated.</div></div><div><h3>Results</h3><div>Model 2 demonstrated the best performance. Under vertical loading, PEKK prostheses showed lower stress than zirconia in the prosthetic body (10–45 %) and the cortical bone (3–40 %), but higher stresses in the implant (4–10 %). Compared to vertical loading, oblique loading generated higher stress but remained within a safe range without compromising function.</div></div><div><h3>Conclusion</h3><div>The fixed-fixed design showed optimal biomechanical performance. The mesial cantilever was more favorable than the distal for stress distribution. Zirconia provided superior stress dissipation, while PEKK showed reduced stress in the prosthetic body but increased stress I the implant and bone.</div></div><div><h3>Clinical significance</h3><div>The study provides prosthodontists with evidence recommending design and materials for 3-unit implant-supported prostheses. Zirconia is ideal for cantilevered designs, resisting high bending forces and minimizing implant stress, while PEKK is more suitable for fixed-fixed designs with lower stress levels.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106872"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and age differentially affect stiffness, injury susceptibility, and composition of murine uterosacral ligaments","authors":"Catalina S. Bastías ,&nbsp;Lea M. Savard ,&nbsp;Kathryn R. Jacobson ,&nbsp;Kathleen A. Connell ,&nbsp;Sarah Calve ,&nbsp;Virginia L. Ferguson ,&nbsp;Callan M. Luetkemeyer","doi":"10.1016/j.jmbbm.2024.106874","DOIUrl":"10.1016/j.jmbbm.2024.106874","url":null,"abstract":"<div><div>Pelvic organ prolapse is a debilitating condition that diminishes quality of life, and it has been linked to pregnancy and aging. Injury of the uterosacral ligaments (USLs), which provide apical support to the pelvic organs, is a major cause of uterine prolapse. In this study, we examined the effect of pregnancy and age on the apparent elastic modulus, susceptibility to collagen damage, and extracellular matrix (ECM) composition of the murine USL. USLs from mice at three different stages of pregnancy and across two age groups were mechanically tested and evaluated for collagen microdamage. Raman spectroscopy was used to evaluate changes in ECM composition. Our findings reveal that (1) all USLs subjected to mechanical stretch sustained collagen microdamage, (2) both pregnancy and age significantly affected USL stiffness and injury susceptibility, and (3) pregnancy, but not age, altered ECM composition. Overall, this work represents a major step toward understanding the role of tissue microstructure and mechanical function in USL injury, which should guide novel ECM-targeted treatment and prevention strategies for uterine prolapse.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106874"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed suction clamps for tensile testing of brain tissue","authors":"J. Zwirner ,&nbsp;J.N. Waddell ,&nbsp;B. Ondruschka ,&nbsp;K.C. Li","doi":"10.1016/j.jmbbm.2024.106873","DOIUrl":"10.1016/j.jmbbm.2024.106873","url":null,"abstract":"<div><div>The conventional mounting of ultra-soft biological tissues often involves gluing it between two plates or manually tightening grips. Both methods demand delicate handling skills and are time-consuming. This study outlines the design and practical application of 3D-printed suction clamps for uniaxial tension tests on brain samples. Successful testing was defined by the absence of relevant slippage or the sample being drawn into the clamp. A total of 112 deer brain samples underwent testing using a universal testing machine after one freeze-thaw cycle. These samples were obtained from eight different brain regions. During sample preparation, 7 out of all samples failed. Among the 105 tests, 89 (85%) were successful. Of the 16 unsuccessful tests, 15 samples (14%) slipped, while only one sample (1%) was drawn into the clamp to an extent that testing became impossible. Medulla oblongata samples exhibited exceptionally high slippage at 38%, whereas samples from the temporal cortex, external capsule, and putamen had the lowest slippage in only one single case. In conclusion, suction clamps facilitate high-throughput testing through user-friendly and rapid sample mounting. Testing success is contingent on the specific brain site, with sample slippage being the primary reason for testing failures, while sample inspiration into the clamp is negligible.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106873"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cutting forces and microdamage during indentation cutting of bone","authors":"Ger Reilly ,&nbsp;David Taylor","doi":"10.1016/j.jmbbm.2024.106870","DOIUrl":"10.1016/j.jmbbm.2024.106870","url":null,"abstract":"<div><div>In surgery, bone can be cut by applying force to a wedge-shaped blade. The published literature is relatively sparse regarding the biomechanics of this type of indentation cutting, especially regarding the relationships between blade geometry, bone quality, cutting force and microdamage. Microdamage created near the cut surfaces can be beneficial, as a trigger for bone remodelling, but it is known that excessive fracture damage can prolong the healing time. In this research, specimens of compact bovine bone were tested by cutting using wedge blades of different geometries. We labelled and measured microdamage occurring during bone cutting for the first time. We found that there were statistically significant effects arising from the variation in wedge angle, edge radius and blade orientation (with respect to bone's anisotropic structure) on both the magnitude of the cutting force and the extent of the microdamage. Interestingly, we found that the amount of damage occurring during cutting is directly correlated to the cutting force which causes the damage, independent of other factors. This work contributes to a better understanding of the biomechanics of this important surgical cutting process.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106870"},"PeriodicalIF":3.3,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrosion fatigue of as-extruded Mg-xGa alloys in simulated bodily fluids with various glucose contents","authors":"Jiebin Zou ,&nbsp;Jia Ma ,&nbsp;Ziyue Zhang ,&nbsp;Lingxiong Sun ,&nbsp;Mohammed R.I. Abueida ,&nbsp;Song Zhang ,&nbsp;Xiaopeng Lu ,&nbsp;Yan Li ,&nbsp;Hongyan Tang ,&nbsp;Qiang Wang","doi":"10.1016/j.jmbbm.2024.106866","DOIUrl":"10.1016/j.jmbbm.2024.106866","url":null,"abstract":"<div><div>The medical devices are subjected to dynamic loads and surrounding physiological condition of the bodily fluids, which will impact the degradation behavior of magnesium (Mg) alloy implants. In this work, the corrosion fatigue (CF) and corrosion behaviors of Mg-<em>x</em>Ga (<em>x</em> = 1, 1.5, and 2 wt%) alloys in Hank's balanced salt solutions (HBSS) with 1 g/L and 3 g/L glucose are thoroughly studied. It is concluded that Mg-2Ga alloy exhibits excellent mechanical and fatigue behaviors. Its ultimate tensile strength (UTS) is 234 MPa, yield strength (YS) is 145 MPa, elongation (EL) is 15%, fatigue limits (<em>σ</em>_<em>f</em>) is 111 MPa in air, 48 MPa in HBSS with 1 g/L glucose, and 66 MPa in HBSS with 3 g/L glucose. The high glucose content in simulated bodily fluids has the function of inhibiting the corrosion reaction of alloy which is favorable to CF.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"163 ","pages":"Article 106866"},"PeriodicalIF":3.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}