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Cannonball metastases as an initial presentation of urothelial bladder carcinoma: a case report and literature review 炮弹转移作为尿路上皮性膀胱癌的初始表现:1例报告和文献复习
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.eucr.2025.103320
Karthik Rayapureddi , Michael Glover , Haiwei Henry Guo , Emily Chan , Sumit A. Shah
Urothelial carcinoma is the most common bladder cancer; although pulmonary spread occurs, cannonball metastases are rare and classically linked to germ cell and renal cell tumors. Bladder cancer typically presents with painless hematuria, so respiratory-only presentations can delay diagnosis. We report a 42-year-old man with progressive dyspnea and innumerable bilateral cannonball lesions as the initial manifestation of muscle-invasive urothelial carcinoma, without hematuria. To our knowledge, this is the first such initial presentation reported. This case underscore including urothelial carcinoma in the differential for pulmonary cannonball lesions and pursuing early biopsy and cystoscopic evaluation even in the absence of urinary symptoms.
尿路上皮癌是最常见的膀胱癌;虽然肺转移发生,但炮弹转移是罕见的,通常与生殖细胞和肾细胞肿瘤有关。膀胱癌通常表现为无痛性血尿,因此只有呼吸道症状会延误诊断。我们报告一名42岁男性,以进行性呼吸困难和无数双侧炮球病变为肌肉侵袭性尿路上皮癌的初始表现,无血尿。据我们所知,这是第一次报道这样的初步表现。本病例强调在鉴别肺炮弹病变时应包括尿路上皮癌,并在没有泌尿系统症状的情况下进行早期活检和膀胱镜检查。
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引用次数: 0
A case of renal primary neuroendocrine tumor (G3) in which 177Lu-PRRT was effective for disease control 177Lu-PRRT有效控制肾原发性神经内分泌肿瘤(G3) 1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.eucr.2025.103337
Saki Inaba , Toshiki Kijima , Mina Takaoka , Toshitaka Uematsu , Kohei Takei , Masahiro Yashi , Kazuyuki Ishida , Taku Aoki , Takao Kamai
Primary renal neuroendocrine tumor (NET) is extremely rare, with no established treatment for advanced cases. We report high-grade (G3) renal NET effectively treated with peptide receptor radionuclide therapy (PRRT). A 30-year-old man was diagnosed with primary renal NET G3 with liver metastases. After everolimus failure, he received 177Lu-DOTATATE (Lutathera®). Although the tumor continued growing after the first cycle, disease stabilized from the second cycle onwards. Stable disease was maintained for 12 months without severe adverse events, preserving quality of life. 177Lu-PRRT is a promising therapeutic option for high-grade, somatostatin receptor-positive renal NET when other treatments fail.
原发性肾神经内分泌肿瘤(NET)极为罕见,对于晚期病例尚无确定的治疗方法。我们报道用肽受体放射性核素疗法(PRRT)有效治疗高级别(G3)肾净网。一名30岁男性被诊断为原发性肾NET G3伴肝转移。依维莫司失败后,他接受了177Lu-DOTATATE (Lutathera®)治疗。虽然肿瘤在第一个周期后继续生长,但从第二个周期开始,疾病就稳定了。病情稳定维持12个月,无严重不良事件发生,维持了患者的生活质量。当其他治疗失败时,lu - prrt是一种很有前途的治疗选择,用于高级别、生长抑素受体阳性的肾NET。
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引用次数: 0
Renal cell carcinoma with anomalous vascular anatomy in a 15-year-old male: Case report with review of literature 15岁男性肾细胞癌伴异常血管解剖一例报告并文献复习
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.eucr.2025.103322
Manzoor Ahmad , Hazique Jameel , Mohd Rafey , Ahmad Sadiq , Gyan Sachin Rao
Pediatric RCC often presents late and with non-specific symptoms posing diagnostic and surgical challenges especially when associated with vascular anomalies.

Case summary

A 15-year-old boy presented with a progressively enlarging right lumbar lump, intermittent painless hematuria, and early-onset hypertension. Examination showed a firm, ballotable right lumbar mass, with microscopic hematuria and elevated plasma renin. CECT revealed an 8.5 × 7 cm enhancing lower-pole right renal mass with dual arterial supply. Open radical nephrectomy was performed. Histopathology confirmed RCC-NOS, Fuhrman grade II, without lymphovascular invasion. Postoperatively, blood pressure normalized and the patient remains disease-free at 12-month follow-up.
儿童肾细胞癌通常表现为晚期和非特异性症状,特别是当与血管异常相关时,对诊断和手术提出了挑战。15岁男童,表现为逐渐增大的右腰椎肿块、间歇性无痛性血尿及早发性高血压。检查显示右腰椎有一个坚硬的球状肿块,镜下有血尿和血浆肾素升高。CECT显示8.5 × 7cm强化右肾下极肿块伴双动脉供应。行开放性根治性肾切除术。组织病理学证实为RCC-NOS, Fuhrman II级,无淋巴血管浸润。术后血压恢复正常,随访12个月无疾病。
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引用次数: 0
Primary renal sclerosing epithelioid fibrosarcoma: A case report 原发性肾硬化上皮样纤维肉瘤1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-31 DOI: 10.1016/j.eucr.2025.103324
Faisl Alslimah , Maher Moazin , Abdulrahman Alshehri , Yasser Alharbi , Ali Howaidi , Saif Alqahtani , Salman Almalki
Sclerosing epithelioid fibrosarcoma (SEF) is a rare variant of fibrosarcoma that primarily arises in the deep soft tissue of the extremities and trunk. Primary SEF in the visceral organs is rare, and only a few cases have been reported. A 20-year-old man was diagnosed with primary renal SEF metastatic to the lymph nodes and bone, which was managed with open right radical nephrectomy and ongoing chemotherapy. Immunohistochemical staining for MUC-4, vimentin, BCL-2, and EMA was positive in tumor cells. Next-generation sequencing revealed the presence of EWSR–CREB3L1 gene fusions and SMARCB1 rearrangement in exon 6.
硬化上皮样纤维肉瘤(SEF)是一种罕见的纤维肉瘤,主要发生在四肢和躯干的深层软组织。在内脏器官的原发性SEF是罕见的,只有少数病例被报道。一名20岁的男性被诊断为原发性肾脏SEF转移到淋巴结和骨,并通过开放式右侧根治性肾切除术和持续化疗进行治疗。肿瘤细胞muc4、vimentin、BCL-2、EMA免疫组化染色呈阳性。下一代测序显示EWSR-CREB3L1基因融合和SMARCB1重排在第6外显子。
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引用次数: 0
Zinner syndrome: Late-Diagnosis in a 55-year-old male and favorable outcome after surgical excision - A case report and review of the literature 津纳综合征:一名55岁男性的晚期诊断和手术切除后的良好结果-一个病例报告和文献回顾
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.eucr.2025.103332
Kinh Luan Thai , Duy Dien Nguyen , Do La Quach , Nho Tinh Le , Le Quy Van Dinh , Minh Dinh Nguyen , Ryan Dobbs , Ho Trong Tan Truong , Tuan Thanh Nguyen , Xuan Thai Ngo
Zinner Syndrome (ZS) is a rare congenital anomaly defined by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. We report a 55-year-old male presenting with chronic perineal pain and LUTS. Imaging confirmed ZS (right renal agenesis, 3.3 × 3.8 cm seminal vesicle cyst). The patient underwent surgical excision, converting from laparoscopic to open due to dense adhesions. He achieved complete symptom resolution and remained stable at two-year follow-up. ZS should be considered in older males with non-specific LUTS. Surgery is effective, and advanced imaging is crucial for diagnosis.
Zinner综合征(ZS)是一种罕见的先天性异常,表现为单侧肾发育不全、同侧精囊囊肿和射精管梗阻。我们报告一个55岁的男性表现为慢性会阴疼痛和LUTS。影像学证实ZS(右肾发育不全,3.3 × 3.8 cm精囊囊肿)。由于粘连较密,患者接受手术切除,由腹腔镜转为开放。患者症状完全缓解,随访两年病情稳定。非特异性LUTS的老年男性应考虑ZS。手术是有效的,先进的影像学对诊断至关重要。
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引用次数: 0
Solitary adrenal gland metastasis detected at 24-month follow-up for muscle-invasive bladder cancer 肌肉浸润性膀胱癌患者24个月随访发现单发肾上腺转移
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.eucr.2025.103334
Nicola Schiavone , Marco Finati , Anna Ricapito , Antonio Fanelli , Gaetano Valerio Palella , Ugo Giovanni Falagario , Luigi Cormio , Carlo Bettocchi , Gian Maria Busetto , Giuseppe Carrieri
Solitary adrenal metastasis from bladder urothelial carcinoma is extremely uncommon. We report a 52-year-old man with high-grade pT3bN0R0 urothelial carcinoma of the bladder, who developed a solitary right adrenal metastasis (59 × 31 mm) 20 months after neoadjuvant chemotherapy and cystectomy (visible at the November 2024 CT, absent in March 2024). Surgical adrenalectomy was aborted due to adhesions and muscular invasion. After systemic therapy, the disease progressed with bilateral adrenal involvement. Adrenal metastases occur in 14 % of bladder cancer cases, isolated adrenal involvement is rare and aggressive; guidelines emphasise individualized multimodal management and suggest that earlier PET/CT may improve outcomes.
膀胱尿路上皮癌单发肾上腺转移极为罕见。我们报告一名52岁男性高级别pT3bN0R0膀胱尿路上皮癌患者,在新辅助化疗和膀胱切除术后20个月发生单发右侧肾上腺转移(59 × 31 mm)(2024年11月CT可见,2024年3月未见)。肾上腺切除术因粘连及肌肉侵入而流产。经过全身治疗后,病情进展到双侧肾上腺受累。14%的膀胱癌病例发生肾上腺转移,孤立的肾上腺受累是罕见的和侵袭性的;指南强调个性化的多模式管理,并建议早期PET/CT可能改善预后。
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引用次数: 0
Management of a crochet hook penetrating perineal injury: A case report 钩针刺穿会阴伤1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.eucr.2025.103336
Asmelash Gebresilase Tewelde , Yirgalem Teklebirhan Gebreziher , Hadush Tesfay Negash , Birhane Mekonen Negash
Removing an embedded barbed hook in the body without causing further tissue damage is a challenge in the emergency department (ED). A crochet hook is one of these barbed hooks.
A 6-year-old male child presented to our hospital after 1 hour of crochet hook needle injury to the perineum. On perineal examination there was a sharp material imbedded in the anterior perineal area on the right side from the medial raphe. His follow-up course was uneventful.
The advance-and-cut method is the most practiced and successful. The choice of management techniques depends on the anatomic location and depth of the hook.
如何在不造成进一步组织损伤的情况下取出体内嵌入的倒钩是急诊科(ED)面临的一个挑战。钩针就是其中一种带刺的钩。一6岁男童会阴钩针损伤1小时后就诊。会阴检查发现在会阴前区右侧有一个尖锐的物质从内侧缝处嵌入。他接下来的旅程平淡无奇。先进后切的方法是最常用和最成功的方法。处理技术的选择取决于钩的解剖位置和深度。
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引用次数: 0
Robot-assisted nephroureterectomy in a patient with left-sided inferior vena cava: a case report 机器人辅助肾输尿管切除术治疗左侧下腔静脉1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.eucr.2025.103333
Masahiro Katsui, Konan Sakai, Takemi Shishido, Hiroki Ide
Left-sided inferior vena cava (LS-IVC) is a rare congenital vascular anomaly that can complicate retroperitoneal surgery because of altered venous and lymphatic anatomy. We report a case of robot-assisted nephroureterectomy performed in a patient with LS-IVC. A 67-year-old woman with right ureteral urothelial carcinoma underwent surgery after careful preoperative vascular assessment. Tailored robotic port placement enabled safe single-docking nephroureterectomy without vascular injury. This case highlights the importance of anatomical awareness and strategic surgical planning when performing robotic surgery in patients with rare vascular anomalies.
左侧下腔静脉(LS-IVC)是一种罕见的先天性血管异常,由于静脉和淋巴解剖结构的改变,可以使腹膜后手术复杂化。我们报告一例机器人辅助肾输尿管切除术在患者进行了LS-IVC。一位67岁的女性右输尿管尿路上皮癌在术前仔细评估血管后接受手术。量身定制的机器人端口放置使安全的单对接肾输尿管切除术没有血管损伤。本病例强调了在对罕见血管异常患者进行机器人手术时解剖意识和手术策略规划的重要性。
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引用次数: 0
Laparoscopic treatment of ureteroduodenal fistula: Case report, technique, and review 腹腔镜治疗输尿管十二指肠瘘:病例报告、技术及回顾
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.eucr.2025.103331
Alexandre Saboia Leitão Junior, Marllon Rodrigues Ferreira, Rommel Prata Regadas, Ricardo Reges Maia de Oliveira, Gabriel Silva Lima
Ureteroduodenal fistula is extremely rare, with fewer than 20 reported cases. We describe a 50-year-old woman with recurrent flank pain and hematuria whose imaging showed proximal ureteral hydronephrosis, a 2-cm stone, and a migrated metallic foreign body. During laparoscopic ureterolithotomy, dense adhesions revealed a fistula caused by transduodenal needle penetration with associated stone formation. Laparoscopic removal of the stone and foreign body, duodenal repair, and ureteral suturing with stent placement were successfully performed. The patient recovered uneventfully and remained asymptomatic at 6 months. This represents the first laparoscopic management of ureteroduodenal fistula, highlighting a safe, kidney-sparing alternative to open surgery.
输尿管十二指肠瘘极为罕见,报告病例不足20例。我们描述了一位50岁的女性复发性腹痛和血尿,其影像学显示输尿管近端肾积水,2厘米结石和金属异物迁移。在腹腔镜输尿管取石术中,密集的粘连显示由经十二指肠针穿入引起的瘘伴伴结石形成。成功行腹腔镜下结石异物取出、十二指肠修复、输尿管缝合及支架置入术。6个月时,患者恢复平稳,无症状。这是输尿管十二指肠瘘的第一次腹腔镜治疗,强调了一种安全的、保留肾脏的开放手术替代方法。
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引用次数: 0
Paraganglioma of the urinary bladder: A case report and discussion of the literature 膀胱副神经节瘤1例报告及文献讨论
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-26 DOI: 10.1016/j.eucr.2025.103327
Samuel S. Iofel , Daniel Groves , Carlos A. Puyo , Lija Joseph , Robert A. Edelstein
Urinary bladder paragangliomas (UBPGL) are rare neuroendocrine tumors that originate from extra-adrenal paraganglia in the bladder.
We report the case of a 67-year-old patient who presented with a submucosal bladder tumor. A hypertensive crisis developed during the initial attempt at cystoscopic resection, and biopsies demonstrated a UBPGL.
The importance of considering UBPGL in the differential diagnosis of submucosal bladder tumors is discussed. Appropriate perioperative blood pressure management and the choice of surgical approach can optimize outcomes and prevent morbidity.
摘要膀胱副神经节瘤(UBPGL)是一种罕见的神经内分泌肿瘤,起源于膀胱肾上腺外副神经节。我们报告的情况下,一个67岁的病人谁提出了粘膜下膀胱肿瘤。在膀胱镜切除的最初尝试中出现高血压危象,活检显示为UBPGL。本文讨论了考虑UBPGL在膀胱粘膜下肿瘤鉴别诊断中的重要性。适当的围手术期血压管理和手术入路的选择可以优化结果和预防发病率。
{"title":"Paraganglioma of the urinary bladder: A case report and discussion of the literature","authors":"Samuel S. Iofel ,&nbsp;Daniel Groves ,&nbsp;Carlos A. Puyo ,&nbsp;Lija Joseph ,&nbsp;Robert A. Edelstein","doi":"10.1016/j.eucr.2025.103327","DOIUrl":"10.1016/j.eucr.2025.103327","url":null,"abstract":"<div><div>Urinary bladder paragangliomas (UBPGL) are rare neuroendocrine tumors that originate from extra-adrenal paraganglia in the bladder.</div><div>We report the case of a 67-year-old patient who presented with a submucosal bladder tumor. A hypertensive crisis developed during the initial attempt at cystoscopic resection, and biopsies demonstrated a UBPGL.</div><div>The importance of considering UBPGL in the differential diagnosis of submucosal bladder tumors is discussed. Appropriate perioperative blood pressure management and the choice of surgical approach can optimize outcomes and prevent morbidity.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103327"},"PeriodicalIF":0.4,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145897991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Urology Case Reports
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