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Case report: Radiographic and cystoscopic manifestations of chronic urogenital Schistosomiasis in an asymptomatic Zimbabwean man with HIV 病例报告:一名无症状的津巴布韦艾滋病毒感染者慢性泌尿生殖器血吸虫病的放射学和膀胱镜表现
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.eucr.2026.103340
Harpreet Kaur , Talal Alkayali , Nathan Williams , Sarah A. Schmalzle
While undergoing evaluation for loss of consciousness and traumatic injuries after a single-vehicle collision, a 55-year-old Zimbabwean man residing in Maryland was incidentally noted to have circumferential bladder wall calcification and thickening on CT imaging. Cystoscopy revealed extensive ‘sandy patches’, confirmed by histopathology to represent calcified eggs of Schistosoma haematobium. Genitourinary symptoms were absent, ova were not identified on urine microscopy, and serum eosinophil level was normal, consistent with the primary infection having occurred at least 20 years prior. While structural and functional genitourinary abnormalities were absent, significant complications can occur even after years of asymptomatic disease.
一名居住在马里兰州的55岁津巴布韦男子在接受一次单一车辆碰撞后的意识丧失和创伤性损伤评估时,偶然发现CT成像显示膀胱壁周向钙化和增厚。膀胱镜检查显示广泛的“沙质斑块”,经组织病理学证实为血血吸虫钙化卵。泌尿生殖系统症状未见,尿镜检未检出卵子,血清嗜酸性粒细胞水平正常,与至少20年前发生的原发感染一致。虽然没有结构性和功能性泌尿生殖系统异常,但即使在无症状疾病多年后,也可能发生明显的并发症。
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引用次数: 0
Prostatic development and verumontanum in a 46,XX karyotype : An embryological paradox redefining diagnostic algorithm for testicular DSD 46,xx核型的前列腺发育和睾丸:一个重新定义睾丸DSD诊断算法的胚胎学悖论
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.eucr.2026.103339
Rifqi Yanda Muhammad , Joko Pitoyo
Evaluation of 46,XX Disorders of Sex Development (DSD) with severe virilization often yields inconclusive results. We report a case where alternative diagnostics resolved a significant phenotype-karyotype discordance. A 2-year-old with a 46,XX karyotype and penoscrotal hypospadias was evaluated. Diagnostic urethroscopy revealed definitive prostatic tissue and a verumontanum. These findings provided anatomical evidence of Wolffian differentiation, distinct from Müllerian persistence, and incompatible with Congenital Adrenal Hyperplasia (CAH). Identifying the prostate established the diagnosis of 46,XX Testicular DSD, shifting management from gonadectomy to hypospadias repair. Urethroscopy is indispensable for resolving diagnostic discrepancies missed by standard protocols.
对46,xx性发育障碍(DSD)伴严重男性化的评估常常产生不确定的结果。我们报告一个病例,其中替代诊断解决显着表型-核型不一致。一个2岁的46,XX核型和阴囊尿道下裂评估。诊断性尿道镜检查显示明确的前列腺组织和尿丘。这些发现提供了Wolffian分化的解剖学证据,不同于m勒氏持续性,与先天性肾上腺增生(CAH)不相容。确定前列腺确定了46,xx睾丸DSD的诊断,将治疗从性腺切除术转移到尿道下裂修复。尿道镜检查对于解决标准方案遗漏的诊断差异是必不可少的。
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引用次数: 0
Corrigendum to: Phentolamine rescue for glanular ischemia in the setting of inadvertent administration of high-dose 1:1,000 epinephrine to glans in distal hypospadias surgery [Urol Case Rep, (59), March 2025, 102941. PMID: 39925745] 对远端尿道下裂手术中不小心给药高剂量1:10 00肾上腺素的情况下,酚度拉明对glu缺血的抢救[ul Case Rep, (59), March 2025, 102941]的更正。PMID: 39925745)
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-07 DOI: 10.1016/j.eucr.2026.103338
Victoria Schulte , Alexandra Carolan , Irina Stanasel , Bruce Schlomer
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引用次数: 0
A rare entity in the retroperitoneum: Case report of a primary seminoma 腹膜后罕见肿瘤:原发性精原细胞瘤1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-02 DOI: 10.1016/j.eucr.2025.103335
Luowu Wang, Ke Yang, Chaojin Liang, Jun xing, Yao Bai
Primary retroperitoneal seminoma is an extremely rare extragonadal germ cell tumor. A 61-year-old male was referred following the discovery of a retroperitoneal mass on routine physical examination. Computed tomography and PET-CT revealed a soft-tissue nodule near the left renal hilum, suggestive of a neoplasm. The patient underwent surgical resection, and histopathology confirmed seminoma. Scrotal ultrasound showed no testicular abnormalities, thereby excluding a metastatic origin and confirming the diagnosis of primary retroperitoneal seminoma. This case underscores the importance of considering this rare entity in the differential diagnosis of retroperitoneal masses.
原发性腹膜后精原细胞瘤是一种极为罕见的生殖道外生殖细胞肿瘤。一位61岁男性病人在常规体格检查中发现腹膜后肿块。计算机断层扫描和PET-CT显示左肾门附近软组织结节,提示肿瘤。患者接受手术切除,组织病理学证实为精原细胞瘤。阴囊超声未见睾丸异常,因此排除转移来源,确认原发性腹膜后精原细胞瘤的诊断。这个病例强调了在鉴别诊断腹膜后肿块时考虑这种罕见实体的重要性。
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引用次数: 0
Cannonball metastases as an initial presentation of urothelial bladder carcinoma: a case report and literature review 炮弹转移作为尿路上皮性膀胱癌的初始表现:1例报告和文献复习
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.eucr.2025.103320
Karthik Rayapureddi , Michael Glover , Haiwei Henry Guo , Emily Chan , Sumit A. Shah
Urothelial carcinoma is the most common bladder cancer; although pulmonary spread occurs, cannonball metastases are rare and classically linked to germ cell and renal cell tumors. Bladder cancer typically presents with painless hematuria, so respiratory-only presentations can delay diagnosis. We report a 42-year-old man with progressive dyspnea and innumerable bilateral cannonball lesions as the initial manifestation of muscle-invasive urothelial carcinoma, without hematuria. To our knowledge, this is the first such initial presentation reported. This case underscore including urothelial carcinoma in the differential for pulmonary cannonball lesions and pursuing early biopsy and cystoscopic evaluation even in the absence of urinary symptoms.
尿路上皮癌是最常见的膀胱癌;虽然肺转移发生,但炮弹转移是罕见的,通常与生殖细胞和肾细胞肿瘤有关。膀胱癌通常表现为无痛性血尿,因此只有呼吸道症状会延误诊断。我们报告一名42岁男性,以进行性呼吸困难和无数双侧炮球病变为肌肉侵袭性尿路上皮癌的初始表现,无血尿。据我们所知,这是第一次报道这样的初步表现。本病例强调在鉴别肺炮弹病变时应包括尿路上皮癌,并在没有泌尿系统症状的情况下进行早期活检和膀胱镜检查。
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引用次数: 0
A case of renal primary neuroendocrine tumor (G3) in which 177Lu-PRRT was effective for disease control 177Lu-PRRT有效控制肾原发性神经内分泌肿瘤(G3) 1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.eucr.2025.103337
Saki Inaba , Toshiki Kijima , Mina Takaoka , Toshitaka Uematsu , Kohei Takei , Masahiro Yashi , Kazuyuki Ishida , Taku Aoki , Takao Kamai
Primary renal neuroendocrine tumor (NET) is extremely rare, with no established treatment for advanced cases. We report high-grade (G3) renal NET effectively treated with peptide receptor radionuclide therapy (PRRT). A 30-year-old man was diagnosed with primary renal NET G3 with liver metastases. After everolimus failure, he received 177Lu-DOTATATE (Lutathera®). Although the tumor continued growing after the first cycle, disease stabilized from the second cycle onwards. Stable disease was maintained for 12 months without severe adverse events, preserving quality of life. 177Lu-PRRT is a promising therapeutic option for high-grade, somatostatin receptor-positive renal NET when other treatments fail.
原发性肾神经内分泌肿瘤(NET)极为罕见,对于晚期病例尚无确定的治疗方法。我们报道用肽受体放射性核素疗法(PRRT)有效治疗高级别(G3)肾净网。一名30岁男性被诊断为原发性肾NET G3伴肝转移。依维莫司失败后,他接受了177Lu-DOTATATE (Lutathera®)治疗。虽然肿瘤在第一个周期后继续生长,但从第二个周期开始,疾病就稳定了。病情稳定维持12个月,无严重不良事件发生,维持了患者的生活质量。当其他治疗失败时,lu - prrt是一种很有前途的治疗选择,用于高级别、生长抑素受体阳性的肾NET。
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引用次数: 0
Renal cell carcinoma with anomalous vascular anatomy in a 15-year-old male: Case report with review of literature 15岁男性肾细胞癌伴异常血管解剖一例报告并文献复习
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.eucr.2025.103322
Manzoor Ahmad , Hazique Jameel , Mohd Rafey , Ahmad Sadiq , Gyan Sachin Rao
Pediatric RCC often presents late and with non-specific symptoms posing diagnostic and surgical challenges especially when associated with vascular anomalies.

Case summary

A 15-year-old boy presented with a progressively enlarging right lumbar lump, intermittent painless hematuria, and early-onset hypertension. Examination showed a firm, ballotable right lumbar mass, with microscopic hematuria and elevated plasma renin. CECT revealed an 8.5 × 7 cm enhancing lower-pole right renal mass with dual arterial supply. Open radical nephrectomy was performed. Histopathology confirmed RCC-NOS, Fuhrman grade II, without lymphovascular invasion. Postoperatively, blood pressure normalized and the patient remains disease-free at 12-month follow-up.
儿童肾细胞癌通常表现为晚期和非特异性症状,特别是当与血管异常相关时,对诊断和手术提出了挑战。15岁男童,表现为逐渐增大的右腰椎肿块、间歇性无痛性血尿及早发性高血压。检查显示右腰椎有一个坚硬的球状肿块,镜下有血尿和血浆肾素升高。CECT显示8.5 × 7cm强化右肾下极肿块伴双动脉供应。行开放性根治性肾切除术。组织病理学证实为RCC-NOS, Fuhrman II级,无淋巴血管浸润。术后血压恢复正常,随访12个月无疾病。
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引用次数: 0
Primary renal sclerosing epithelioid fibrosarcoma: A case report 原发性肾硬化上皮样纤维肉瘤1例
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-31 DOI: 10.1016/j.eucr.2025.103324
Faisl Alslimah , Maher Moazin , Abdulrahman Alshehri , Yasser Alharbi , Ali Howaidi , Saif Alqahtani , Salman Almalki
Sclerosing epithelioid fibrosarcoma (SEF) is a rare variant of fibrosarcoma that primarily arises in the deep soft tissue of the extremities and trunk. Primary SEF in the visceral organs is rare, and only a few cases have been reported. A 20-year-old man was diagnosed with primary renal SEF metastatic to the lymph nodes and bone, which was managed with open right radical nephrectomy and ongoing chemotherapy. Immunohistochemical staining for MUC-4, vimentin, BCL-2, and EMA was positive in tumor cells. Next-generation sequencing revealed the presence of EWSR–CREB3L1 gene fusions and SMARCB1 rearrangement in exon 6.
硬化上皮样纤维肉瘤(SEF)是一种罕见的纤维肉瘤,主要发生在四肢和躯干的深层软组织。在内脏器官的原发性SEF是罕见的,只有少数病例被报道。一名20岁的男性被诊断为原发性肾脏SEF转移到淋巴结和骨,并通过开放式右侧根治性肾切除术和持续化疗进行治疗。肿瘤细胞muc4、vimentin、BCL-2、EMA免疫组化染色呈阳性。下一代测序显示EWSR-CREB3L1基因融合和SMARCB1重排在第6外显子。
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引用次数: 0
Zinner syndrome: Late-Diagnosis in a 55-year-old male and favorable outcome after surgical excision - A case report and review of the literature 津纳综合征:一名55岁男性的晚期诊断和手术切除后的良好结果-一个病例报告和文献回顾
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.eucr.2025.103332
Kinh Luan Thai , Duy Dien Nguyen , Do La Quach , Nho Tinh Le , Le Quy Van Dinh , Minh Dinh Nguyen , Ryan Dobbs , Ho Trong Tan Truong , Tuan Thanh Nguyen , Xuan Thai Ngo
Zinner Syndrome (ZS) is a rare congenital anomaly defined by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. We report a 55-year-old male presenting with chronic perineal pain and LUTS. Imaging confirmed ZS (right renal agenesis, 3.3 × 3.8 cm seminal vesicle cyst). The patient underwent surgical excision, converting from laparoscopic to open due to dense adhesions. He achieved complete symptom resolution and remained stable at two-year follow-up. ZS should be considered in older males with non-specific LUTS. Surgery is effective, and advanced imaging is crucial for diagnosis.
Zinner综合征(ZS)是一种罕见的先天性异常,表现为单侧肾发育不全、同侧精囊囊肿和射精管梗阻。我们报告一个55岁的男性表现为慢性会阴疼痛和LUTS。影像学证实ZS(右肾发育不全,3.3 × 3.8 cm精囊囊肿)。由于粘连较密,患者接受手术切除,由腹腔镜转为开放。患者症状完全缓解,随访两年病情稳定。非特异性LUTS的老年男性应考虑ZS。手术是有效的,先进的影像学对诊断至关重要。
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引用次数: 0
Solitary adrenal gland metastasis detected at 24-month follow-up for muscle-invasive bladder cancer 肌肉浸润性膀胱癌患者24个月随访发现单发肾上腺转移
IF 0.4 Q4 UROLOGY & NEPHROLOGY Pub Date : 2025-12-30 DOI: 10.1016/j.eucr.2025.103334
Nicola Schiavone , Marco Finati , Anna Ricapito , Antonio Fanelli , Gaetano Valerio Palella , Ugo Giovanni Falagario , Luigi Cormio , Carlo Bettocchi , Gian Maria Busetto , Giuseppe Carrieri
Solitary adrenal metastasis from bladder urothelial carcinoma is extremely uncommon. We report a 52-year-old man with high-grade pT3bN0R0 urothelial carcinoma of the bladder, who developed a solitary right adrenal metastasis (59 × 31 mm) 20 months after neoadjuvant chemotherapy and cystectomy (visible at the November 2024 CT, absent in March 2024). Surgical adrenalectomy was aborted due to adhesions and muscular invasion. After systemic therapy, the disease progressed with bilateral adrenal involvement. Adrenal metastases occur in 14 % of bladder cancer cases, isolated adrenal involvement is rare and aggressive; guidelines emphasise individualized multimodal management and suggest that earlier PET/CT may improve outcomes.
膀胱尿路上皮癌单发肾上腺转移极为罕见。我们报告一名52岁男性高级别pT3bN0R0膀胱尿路上皮癌患者,在新辅助化疗和膀胱切除术后20个月发生单发右侧肾上腺转移(59 × 31 mm)(2024年11月CT可见,2024年3月未见)。肾上腺切除术因粘连及肌肉侵入而流产。经过全身治疗后,病情进展到双侧肾上腺受累。14%的膀胱癌病例发生肾上腺转移,孤立的肾上腺受累是罕见的和侵袭性的;指南强调个性化的多模式管理,并建议早期PET/CT可能改善预后。
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引用次数: 0
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Urology Case Reports
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