Pub Date : 2026-01-14DOI: 10.1016/j.eucr.2026.103348
Katherine Arias , Myriam Lili Ceballos , Juan Lukas Ordoñez , Edwin Abraham Medina , Manuel Duque
Papillary urothelial tumor of low malignant potential is rare in pediatric patients, accounting for only 0.1–0.4 % of bladder tumors under 20 years of age. We present the case of a 14-year-old female with Poland syndrome and history of laryngeal, nasal, and colonic polyposis presented with intermittent gross hematuria, suprapubic pain, and urinary incontinence. Transurethral resection (TUR) identified a papillary urothelial neoplasm of low malignant potential. Genetic testing revealed an ARMC4 variant (primary ciliary dyskinesia), with no known association to PUNLMP. This case highlights the importance of a stepwise approach including early imaging, histologic confirmation, and endoscopic monitoring.
{"title":"Papillary urothelial tumor of low malignant potential in a pediatric patient: case associated with Poland syndrome","authors":"Katherine Arias , Myriam Lili Ceballos , Juan Lukas Ordoñez , Edwin Abraham Medina , Manuel Duque","doi":"10.1016/j.eucr.2026.103348","DOIUrl":"10.1016/j.eucr.2026.103348","url":null,"abstract":"<div><div>Papillary urothelial tumor of low malignant potential is rare in pediatric patients, accounting for only 0.1–0.4 % of bladder tumors under 20 years of age. We present the case of a 14-year-old female with Poland syndrome and history of laryngeal, nasal, and colonic polyposis presented with intermittent gross hematuria, suprapubic pain, and urinary incontinence. Transurethral resection (TUR) identified a papillary urothelial neoplasm of low malignant potential. Genetic testing revealed an ARMC4 variant (primary ciliary dyskinesia), with no known association to PUNLMP. This case highlights the importance of a stepwise approach including early imaging, histologic confirmation, and endoscopic monitoring.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103348"},"PeriodicalIF":0.4,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuroendocrine prostate cancer (NEPC) is often considered treatment-induced. We report a case with pre-existing neuroendocrine differentiation that became evident during androgen receptor signaling inhibitor (ARSI) therapy. A 79-year-old man with metastatic prostate cancer received degarelix plus apalutamide. Prostate-specific antigen (PSA) decreased to <0.01 ng/mL. Subsequently, lung and liver metastases developed while PSA remained low, with neuron-specific enolase rising to 584 ng/mL. Liver biopsy revealed PSA-negative, neuroendocrine marker-positive carcinoma. Re-evaluation of initial biopsy demonstrated positivity for both PSA and neuroendocrine markers, indicating pre-existing neuroendocrine differentiation.
{"title":"Clonal selection of pre-existing neuroendocrine component in prostate cancer during androgen receptor signaling inhibitor therapy: A case report","authors":"Haruka Kubota , Toshiki Kijima , Hadzki Matsuda , Toshitaka Uematsu , Kohei Takei , Masahiro Yashi , Kazuyuki Ishida , Takao Kamai","doi":"10.1016/j.eucr.2026.103347","DOIUrl":"10.1016/j.eucr.2026.103347","url":null,"abstract":"<div><div>Neuroendocrine prostate cancer (NEPC) <u>is often</u> considered treatment-induced. We report a case with pre-existing neuroendocrine differentiation that became evident during androgen receptor signaling inhibitor (ARSI) therapy. A 79-year-old man with metastatic prostate cancer <u>received</u> degarelix plus apalutamide. Prostate-specific antigen (PSA) decreased to <0.01 ng/mL. Subsequently, lung and liver metastases developed while PSA remained low, with neuron-specific enolase rising to 584 ng/mL. Liver biopsy revealed PSA-negative, neuroendocrine marker-positive carcinoma. Re-evaluation of initial biopsy demonstrated positivity for both PSA and neuroendocrine markers, indicating pre-existing neuroendocrine differentiation.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103347"},"PeriodicalIF":0.4,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1016/j.eucr.2026.103342
Paolo Guedes Oliva , Pablo Jiménez Marrero , Rubén Espino Espino , Reinaldo Marrero Domínguez , Irene Expósito Remedios , Rafael Camacho Galán
We report the case of a 26-year-old man diagnosed with multifocal bladder paraganglioma, an exceptionally rare neuroendocrine tumor. The patient presented with hypertension and adrenergic symptoms triggered by micturition, associated with elevated metanephrines and multiple pelvic lesions. He underwent complete laparoscopic resection, including partial cystectomy, achieving initial biochemical remission. Early local recurrence and subsequent peritoneal carcinomatosis, an uncommon metastatic pattern, were observed, requiring systemic therapy. This case highlights the diagnostic challenges, potential for aggressive behavior, and limited therapeutic options in metastatic bladder paraganglioma, underscoring the need for high clinical suspicion, adequate preoperative management, and long-term follow-up.
{"title":"Recurrent bladder paraganglioma with peritoneal dissemination: An unusual pattern of metastatic progression. Case report and literature review","authors":"Paolo Guedes Oliva , Pablo Jiménez Marrero , Rubén Espino Espino , Reinaldo Marrero Domínguez , Irene Expósito Remedios , Rafael Camacho Galán","doi":"10.1016/j.eucr.2026.103342","DOIUrl":"10.1016/j.eucr.2026.103342","url":null,"abstract":"<div><div>We report the case of a 26-year-old man diagnosed with multifocal bladder paraganglioma, an exceptionally rare neuroendocrine tumor. The patient presented with hypertension and adrenergic symptoms triggered by micturition, associated with elevated metanephrines and multiple pelvic lesions. He underwent complete laparoscopic resection, including partial cystectomy, achieving initial biochemical remission. Early local recurrence and subsequent peritoneal carcinomatosis<u>, an uncommon metastatic pattern,</u> were observed, requiring systemic therapy. This case highlights the diagnostic challenges, potential for aggressive behavior, and limited therapeutic options in metastatic bladder paraganglioma, underscoring the need for high clinical suspicion, adequate preoperative management, and long-term follow-up.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103342"},"PeriodicalIF":0.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1016/j.eucr.2026.103344
Lianpeng Gao , Bo Zhu , Xiaoxia Li , Yuyun Wu , Wenbo Zhou , Jiongming Li
A complex pyelocutaneous fistula developed after microwave ablation for recurrent clear cell renal carcinoma following partial nephrectomy. The fistula persisted despite prolonged drainage, antibiotics, ureteral stenting, and other conservative measures. Definitive management required laparoscopic radical nephrectomy with complete excision of the fistulous tract and involved psoas tissue. Histopathology showed chronic inflammation without residual malignancy. This case supports early consideration of radical nephrectomy for refractory, anatomically complex pyelocutaneous fistulas.
{"title":"[A rare case of complex pyelocutaneous fistula following microwave ablation for recurrent renal cell carcinoma successfully managed with radical nephrectomy]","authors":"Lianpeng Gao , Bo Zhu , Xiaoxia Li , Yuyun Wu , Wenbo Zhou , Jiongming Li","doi":"10.1016/j.eucr.2026.103344","DOIUrl":"10.1016/j.eucr.2026.103344","url":null,"abstract":"<div><div>A complex pyelocutaneous fistula developed after microwave ablation for recurrent clear cell renal carcinoma following partial nephrectomy. The fistula persisted despite prolonged drainage, antibiotics, ureteral stenting, and other conservative measures. Definitive management required laparoscopic radical nephrectomy with complete excision of the fistulous tract and involved psoas tissue. Histopathology showed chronic inflammation without residual malignancy. This case supports early consideration of radical nephrectomy for refractory, anatomically complex pyelocutaneous fistulas.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103344"},"PeriodicalIF":0.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1016/j.eucr.2026.103343
Sami Chebbi , Houssem Bel Hadj Alouane , Mohamed Amine Oueslati , Nidham Eddine Kchir , Sami Ben Rhouma
We report a case of bilateral pheochromocytomas in a 45-year-old man with cutaneous findings suggestive of a hereditary disease. Imaging revealed a large right adrenal tumor extending into the inferior vena cava (IVC) and a smaller contralateral lesion. The patient underwent right adrenalectomy with IVC thrombectomy, while the left lesion was managed conservatively. Histopathology confirmed pheochromocytoma with extensive IVC tumor thrombus and no distant metastases. A residual IVC thrombus was treated with anticoagulation and remained stable on follow-up imaging. This case highlights the complexity of managing hereditary pheochromocytomas with vascular invasion.
{"title":"Bilateral pheochromocytomas with locally advanced right adrenal tumor extending into the inferior vena cava in a suspected Von Hippel–Lindau syndrome: A case report","authors":"Sami Chebbi , Houssem Bel Hadj Alouane , Mohamed Amine Oueslati , Nidham Eddine Kchir , Sami Ben Rhouma","doi":"10.1016/j.eucr.2026.103343","DOIUrl":"10.1016/j.eucr.2026.103343","url":null,"abstract":"<div><div>We report a case of bilateral pheochromocytomas in a 45-year-old man with cutaneous findings suggestive of a hereditary disease. Imaging revealed a large right adrenal tumor extending into the inferior vena cava (IVC) and a smaller contralateral lesion. The patient underwent right adrenalectomy with IVC thrombectomy, while the left lesion was managed conservatively. Histopathology confirmed pheochromocytoma with extensive IVC tumor thrombus and no distant metastases. A residual IVC thrombus was treated with anticoagulation and remained stable on follow-up imaging. This case highlights the complexity of managing hereditary pheochromocytomas with vascular invasion.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103343"},"PeriodicalIF":0.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1016/j.eucr.2026.103345
Danhong Yu , Nianyu Xue
Testicular plasmacytoma is an extremely rare malignant tumour whose clinical manifestations resemble those of common testicular tumours, making preoperative diagnosis challenging. This paper reports a case of a 63-year-old male patient who presented for consultation due to'unintentionally discovering enlargement of the right scrotum for four days’. The ultrasound findings bear a striking resemblance to lymphoma, leading to misdiagnosis as lymphoma on ultrasound. Following radical orchiectomy, pathological and immunohistochemical examination confirmed the diagnosis of plasmacytoma. Although rare, testicular plasmacytoma should be considered as part of the differential diagnosis for testicular masses.
{"title":"A case report of testicular plasmacytoma misdiagnosed as lymphoma by ultrasound","authors":"Danhong Yu , Nianyu Xue","doi":"10.1016/j.eucr.2026.103345","DOIUrl":"10.1016/j.eucr.2026.103345","url":null,"abstract":"<div><div>Testicular plasmacytoma is an extremely rare malignant tumour whose clinical manifestations resemble those of common testicular tumours, making preoperative diagnosis challenging. This paper reports a case of a 63-year-old male patient who presented for consultation due to'unintentionally discovering enlargement of the right scrotum for four days’. The ultrasound findings bear a striking resemblance to lymphoma, leading to misdiagnosis as lymphoma on ultrasound. Following radical orchiectomy, pathological and immunohistochemical examination confirmed the diagnosis of plasmacytoma. Although rare, testicular plasmacytoma should be considered as part of the differential diagnosis for testicular masses.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103345"},"PeriodicalIF":0.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.eucr.2026.103340
Harpreet Kaur , Talal Alkayali , Nathan Williams , Sarah A. Schmalzle
While undergoing evaluation for loss of consciousness and traumatic injuries after a single-vehicle collision, a 55-year-old Zimbabwean man residing in Maryland was incidentally noted to have circumferential bladder wall calcification and thickening on CT imaging. Cystoscopy revealed extensive ‘sandy patches’, confirmed by histopathology to represent calcified eggs of Schistosoma haematobium. Genitourinary symptoms were absent, ova were not identified on urine microscopy, and serum eosinophil level was normal, consistent with the primary infection having occurred at least 20 years prior. While structural and functional genitourinary abnormalities were absent, significant complications can occur even after years of asymptomatic disease.
{"title":"Case report: Radiographic and cystoscopic manifestations of chronic urogenital Schistosomiasis in an asymptomatic Zimbabwean man with HIV","authors":"Harpreet Kaur , Talal Alkayali , Nathan Williams , Sarah A. Schmalzle","doi":"10.1016/j.eucr.2026.103340","DOIUrl":"10.1016/j.eucr.2026.103340","url":null,"abstract":"<div><div>While undergoing evaluation for loss of consciousness and traumatic injuries after a single-vehicle collision, a 55-year-old Zimbabwean man residing in Maryland was incidentally noted to have circumferential bladder wall calcification and thickening on CT imaging. Cystoscopy revealed extensive ‘sandy patches’, confirmed by histopathology to represent calcified eggs of <em>Schistosoma haematobium</em>. Genitourinary symptoms were absent, ova were not identified on urine microscopy, and serum eosinophil level was normal, consistent with the primary infection having occurred at least 20 years prior. While structural and functional genitourinary abnormalities were absent, significant complications can occur even after years of asymptomatic disease.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103340"},"PeriodicalIF":0.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.eucr.2026.103339
Rifqi Yanda Muhammad , Joko Pitoyo
Evaluation of 46,XX Disorders of Sex Development (DSD) with severe virilization often yields inconclusive results. We report a case where alternative diagnostics resolved a significant phenotype-karyotype discordance. A 2-year-old with a 46,XX karyotype and penoscrotal hypospadias was evaluated. Diagnostic urethroscopy revealed definitive prostatic tissue and a verumontanum. These findings provided anatomical evidence of Wolffian differentiation, distinct from Müllerian persistence, and incompatible with Congenital Adrenal Hyperplasia (CAH). Identifying the prostate established the diagnosis of 46,XX Testicular DSD, shifting management from gonadectomy to hypospadias repair. Urethroscopy is indispensable for resolving diagnostic discrepancies missed by standard protocols.
{"title":"Prostatic development and verumontanum in a 46,XX karyotype : An embryological paradox redefining diagnostic algorithm for testicular DSD","authors":"Rifqi Yanda Muhammad , Joko Pitoyo","doi":"10.1016/j.eucr.2026.103339","DOIUrl":"10.1016/j.eucr.2026.103339","url":null,"abstract":"<div><div>Evaluation of 46,XX Disorders of Sex Development (DSD) with severe virilization often yields inconclusive results. We report a case where alternative diagnostics resolved a significant phenotype-karyotype discordance. A 2-year-old with a 46,XX karyotype and penoscrotal hypospadias was evaluated. Diagnostic urethroscopy revealed definitive prostatic tissue and a verumontanum. These findings provided anatomical evidence of Wolffian differentiation, distinct from Müllerian persistence, and incompatible with Congenital Adrenal Hyperplasia (CAH). Identifying the prostate established the diagnosis of 46,XX Testicular DSD, shifting management from gonadectomy to hypospadias repair. Urethroscopy is indispensable for resolving diagnostic discrepancies missed by standard protocols.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103339"},"PeriodicalIF":0.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.eucr.2026.103338
Victoria Schulte , Alexandra Carolan , Irina Stanasel , Bruce Schlomer
{"title":"Corrigendum to: Phentolamine rescue for glanular ischemia in the setting of inadvertent administration of high-dose 1:1,000 epinephrine to glans in distal hypospadias surgery [Urol Case Rep, (59), March 2025, 102941. PMID: 39925745]","authors":"Victoria Schulte , Alexandra Carolan , Irina Stanasel , Bruce Schlomer","doi":"10.1016/j.eucr.2026.103338","DOIUrl":"10.1016/j.eucr.2026.103338","url":null,"abstract":"","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103338"},"PeriodicalIF":0.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.eucr.2025.103335
Luowu Wang, Ke Yang, Chaojin Liang, Jun xing, Yao Bai
Primary retroperitoneal seminoma is an extremely rare extragonadal germ cell tumor. A 61-year-old male was referred following the discovery of a retroperitoneal mass on routine physical examination. Computed tomography and PET-CT revealed a soft-tissue nodule near the left renal hilum, suggestive of a neoplasm. The patient underwent surgical resection, and histopathology confirmed seminoma. Scrotal ultrasound showed no testicular abnormalities, thereby excluding a metastatic origin and confirming the diagnosis of primary retroperitoneal seminoma. This case underscores the importance of considering this rare entity in the differential diagnosis of retroperitoneal masses.
{"title":"A rare entity in the retroperitoneum: Case report of a primary seminoma","authors":"Luowu Wang, Ke Yang, Chaojin Liang, Jun xing, Yao Bai","doi":"10.1016/j.eucr.2025.103335","DOIUrl":"10.1016/j.eucr.2025.103335","url":null,"abstract":"<div><div>Primary retroperitoneal seminoma is an extremely rare extragonadal germ cell tumor. A 61-year-old male was referred following the discovery of a retroperitoneal mass on routine physical examination. Computed tomography and PET-CT revealed a soft-tissue nodule near the left renal hilum, suggestive of a neoplasm. The patient underwent surgical resection, and histopathology confirmed seminoma. Scrotal ultrasound showed no testicular abnormalities, thereby excluding a metastatic origin and confirming the diagnosis of primary retroperitoneal seminoma. This case underscores the importance of considering this rare entity in the differential diagnosis of retroperitoneal masses.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"65 ","pages":"Article 103335"},"PeriodicalIF":0.4,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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