Diagnostic and treatment guidelines for renal medullary carcinoma are not established. A 52-year-old Japanese woman presented to her general physician with symptoms of cough and respiratory distress. A primary malignant tumor of the right kidney and multiple metastases were suspected during imaging; therefore, she was referred to our department for consultation. The results of a computed tomography-guided tumor biopsy revealed a diagnosis of renal medullary carcinoma without sickle cell hemoglobinopathy. This case was atypical because renal medullary carcinoma was not accompanied by sickle cell hemoglobinopathy and the patient was Japanese.
{"title":"A rare case of renal medullary carcinoma without sickle cell hemoglobinopathy in a Japanese woman","authors":"Masanori Ishizaki , Masaru Hasumi , Kazumichi Muramatsu , Misa Iijima , Nobuaki Shimizu","doi":"10.1016/j.eucr.2025.102996","DOIUrl":"10.1016/j.eucr.2025.102996","url":null,"abstract":"<div><div>Diagnostic and treatment guidelines for renal medullary carcinoma are not established. A 52-year-old Japanese woman presented to her general physician with symptoms of cough and respiratory distress. A primary malignant tumor of the right kidney and multiple metastases were suspected during imaging; therefore, she was referred to our department for consultation. The results of a computed tomography-guided tumor biopsy revealed a diagnosis of renal medullary carcinoma without sickle cell hemoglobinopathy. This case was atypical because renal medullary carcinoma was not accompanied by sickle cell hemoglobinopathy and the patient was Japanese.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"60 ","pages":"Article 102996"},"PeriodicalIF":0.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-02DOI: 10.1016/j.eucr.2025.102997
Juliana Arenas Hoyos , Jeff Lawrence Pugach , Lynne M. Eger , Sandy Cope-Yokoyama , Shane F. Batie
Schistosomiasis is a parasitic infection that may be difficult to diagnose in non-endemic regions and may manifest with epididymal involvement.
Testicular schistosomiasis remains a rare disease. The diagnosis is based on clinical suspicion due to a low degree of specificity when it comes to laboratory tests and imaging studies. Treatment mainstays are anthelminthic medication and excision.
We present the first report of epididymal schistosomiasis in a pediatric patient in the United States. Patients require a definitive histologic diagnosis. It is helpful to obtain a thorough history to elucidate exposure to endemic areas as part of assessment and treatment.
{"title":"Pediatric epididymal schistosomiasis, challenging diagnosis, and implications","authors":"Juliana Arenas Hoyos , Jeff Lawrence Pugach , Lynne M. Eger , Sandy Cope-Yokoyama , Shane F. Batie","doi":"10.1016/j.eucr.2025.102997","DOIUrl":"10.1016/j.eucr.2025.102997","url":null,"abstract":"<div><div>Schistosomiasis is a parasitic infection that may be difficult to diagnose in non-endemic regions and may manifest with epididymal involvement.</div><div>Testicular schistosomiasis remains a rare disease. The diagnosis is based on clinical suspicion due to a low degree of specificity when it comes to laboratory tests and imaging studies. Treatment mainstays are anthelminthic medication and excision.</div><div>We present the first report of epididymal schistosomiasis in a pediatric patient in the United States. Patients require a definitive histologic diagnosis. It is helpful to obtain a thorough history to elucidate exposure to endemic areas as part of assessment and treatment.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"60 ","pages":"Article 102997"},"PeriodicalIF":0.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.eucr.2025.102995
Dar Yoffe , Joseph GR. Paturzo , Alexandra Payne , Erin Hays , Michael Markel , Gaurav Bandi
Paraneoplastic Limbic Encephalitis (PLE) is a neurocognitive condition caused by an immune response to neuronal proteins linked to malignancy, such as testicular cancer. We report a 25-year-old male with cognitive and personality changes. His initial MRI showed vasogenic edema. A subsequent CT scan revealed bilateral hydroceles, and a follow-up scrotal US uncovered a right testicular mass, leading to a radical orchiectomy that confirmed a Sertoli cell tumor. Following orchiectomy and immunomodulating therapy, the patient's symptoms showed near-complete resolution within a year. This is the first documented case of PLE resulting from a non-germ cell testicular tumor.
{"title":"Paraneoplastic limbic encephalitis secondary to sertoli cell testicular tumor: A case report","authors":"Dar Yoffe , Joseph GR. Paturzo , Alexandra Payne , Erin Hays , Michael Markel , Gaurav Bandi","doi":"10.1016/j.eucr.2025.102995","DOIUrl":"10.1016/j.eucr.2025.102995","url":null,"abstract":"<div><div>Paraneoplastic Limbic Encephalitis (PLE) is a neurocognitive condition caused by an immune response to neuronal proteins linked to malignancy, such as testicular cancer. We report a 25-year-old male with cognitive and personality changes. <u>His initial</u> MRI showed vasogenic edema. <u>A subsequent</u> CT scan revealed bilateral hydroceles, and a follow-up scrotal US uncovered a right testicular mass, leading to a radical orchiectomy that confirmed a Sertoli cell tumor. Following orchiectomy and immunomodulating therapy, the patient's symptoms showed near-complete <u>resolution</u> within a year. This is the first documented case of PLE resulting from a non-germ cell testicular tumor.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"60 ","pages":"Article 102995"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01DOI: 10.1016/j.eucr.2025.102993
Luca Bertozzi , Eileen Zhang , Mohadese Behtaj , Olivia Gordon , Michael J. Whalen
Prostate basal cell carcinoma (BCC) is a rare pathologic variant with a poorly understood molecular profile. Here, we describe a case of prostate BCC and compare its genetic alterations to cases in the literature. After presenting with hematuria, our patient underwent definitive radical prostatectomy for his localized biopsy-proven BCC. Somatic and germline testing revealed mutations in PIK3R1, KMT2D, and NOTCH1, and MUTYH, NBN, and MSH3, respectively. Upon literature review, we found that prostate BCC mutations disrupt cell growth, epigenetic regulation, and cell fate determination. With no consensus guidelines available, experimental targeted therapies have shown promise for prostate BCC management.
{"title":"Molecular profiling of basal cell carcinoma of the prostate: A case report and literature review","authors":"Luca Bertozzi , Eileen Zhang , Mohadese Behtaj , Olivia Gordon , Michael J. Whalen","doi":"10.1016/j.eucr.2025.102993","DOIUrl":"10.1016/j.eucr.2025.102993","url":null,"abstract":"<div><div>Prostate basal cell carcinoma (BCC) is a rare pathologic variant with a poorly understood molecular profile. Here, we describe a case of prostate BCC and compare its genetic alterations to cases in the literature. After presenting with hematuria, our patient underwent definitive radical prostatectomy for his localized biopsy-proven BCC. Somatic and germline testing revealed mutations in PIK3R1, KMT2D, and NOTCH1, and MUTYH, NBN, and MSH3, respectively. Upon literature review, we found that prostate BCC mutations disrupt cell growth, epigenetic regulation, and cell fate determination. With no consensus guidelines available, experimental targeted therapies have shown promise for prostate BCC management.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"60 ","pages":"Article 102993"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urinary myiasis, a rare condition caused by the infestation of fly larvae in the urinary tract, poses diagnostic challenges due to its nonspecific symptoms and low prevalence. We report a 52-year-old woman with persistent dysuria, frequency despite multiple treatments for suspected infections. Cystoscopy revealed erythema and debris, but imaging and laboratory tests were unremarkable. A live larva was identified in urine analysis, confirming the diagnosis. Treatment involved improved hygiene and hydration. Prompt recognition and management is needed to prevent complications. Awareness of this rare condition is crucial, particularly in individuals with poor sanitation and underlying urinary tract abnormalities.
{"title":"Urinary myiasis; a case report and literature review","authors":"Siavash Vaziri , Zeinab Mohseni Afshar , Mohammad-Bagher Rajabalian , Behzad Narouie , Babak Sayad , Seyed Hamid Madani , Zohreh Bartani , Mehdi Sedighi , Negar Radpour , Hamidreza Momeni","doi":"10.1016/j.eucr.2025.102992","DOIUrl":"10.1016/j.eucr.2025.102992","url":null,"abstract":"<div><div>Urinary myiasis, a rare condition caused by the infestation of fly larvae in the urinary tract, poses diagnostic challenges due to its nonspecific symptoms and low prevalence. We report a 52-year-old woman with persistent dysuria, frequency despite multiple treatments for suspected infections. Cystoscopy revealed erythema and debris, but imaging and laboratory tests were unremarkable. A live larva was identified in urine analysis, confirming the diagnosis. Treatment involved improved hygiene and hydration. Prompt recognition and management is needed to prevent complications. Awareness of this rare condition is crucial, particularly in individuals with poor sanitation and underlying urinary tract abnormalities.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"59 ","pages":"Article 102992"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1016/j.eucr.2025.102988
Kunind Oberoi , Kapil Sethi
A 73-year-old man underwent uncomplicated robotic-assisted laparoscopic prostatectomy (RALP). Nineteen days later, he developed constipation, obstipation, and distension. Imaging confirmed sigmoid volvulus, and he was subsequently managed with endoscopic detorsion. Recurrence occurred two months later, requiring colectomy.
Sigmoid volvulus has not been reported after RALP. RALP may contribute to sigmoid volvulus due to operative patient positioning, pneumoperitoneum, and mesenteric mobilization. Clinicians should be aware of this potential complication, particularly in elderly patients with predisposing anatomical factors. Consideration may be needed to laterally repair any sigmoid released during dissection in RALP.
{"title":"Recurrent sigmoid volvulus after robotic-assisted laparoscopic prostatectomy","authors":"Kunind Oberoi , Kapil Sethi","doi":"10.1016/j.eucr.2025.102988","DOIUrl":"10.1016/j.eucr.2025.102988","url":null,"abstract":"<div><div>A 73-year-old man underwent uncomplicated robotic-assisted laparoscopic prostatectomy (RALP). Nineteen days later, he developed constipation, obstipation, and distension. Imaging confirmed sigmoid volvulus, and he was subsequently managed with endoscopic detorsion. Recurrence occurred two months later, requiring colectomy.</div><div>Sigmoid volvulus has not been reported after RALP. RALP may contribute to sigmoid volvulus due to operative patient positioning, pneumoperitoneum, and mesenteric mobilization. Clinicians should be aware of this potential complication, particularly in elderly patients with predisposing anatomical factors. Consideration may be needed to laterally repair any sigmoid released during dissection in RALP.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"59 ","pages":"Article 102988"},"PeriodicalIF":0.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-19DOI: 10.1016/j.eucr.2025.102989
Kanagavel Yathwin, Rajiv Raj D., Vittalraj Pavitra, Sanjanika S., Balaji Singh K.
Para-testicular fibrous pseudotumors (PFP) are rare benign reactive lesions comprising of 6 % of para-testicular masses. Often misdiagnosed as malignant due to clinical and radiological overlap, they are frequently treated with aggressive surgery. We report a case of a 70-year-old male with a left inguinal swelling diagnosed post-orchidectomy as PFP. Histopathology revealed collagen-rich fibrotic tissue with lymphoplasmacytic infiltrates and IgG4-positive plasma cells. While PFP treatment requires surgical resection, testicle-sparing procedures with intraoperative frozen section assessment may prevent unnecessary orchidectomy. Further studies are needed to establish diagnostic protocols and explore the association between PFP and IgG4-related diseases.
{"title":"IgG4-related para-testicular fibrous pseudotumor- A rare benign testicular mass mimicking malignancy: A case report and literature review","authors":"Kanagavel Yathwin, Rajiv Raj D., Vittalraj Pavitra, Sanjanika S., Balaji Singh K.","doi":"10.1016/j.eucr.2025.102989","DOIUrl":"10.1016/j.eucr.2025.102989","url":null,"abstract":"<div><div>Para-testicular fibrous pseudotumors (PFP) are rare benign reactive lesions comprising of 6 % of para-testicular masses. Often misdiagnosed as malignant due to clinical and radiological overlap, they are frequently treated with aggressive surgery. We report a case of a 70-year-old male with a left inguinal swelling diagnosed post-orchidectomy as PFP. Histopathology revealed collagen-rich fibrotic tissue with lymphoplasmacytic infiltrates and IgG4-positive plasma cells. While PFP treatment requires surgical resection, testicle-sparing procedures with intraoperative frozen section assessment may prevent unnecessary orchidectomy. Further studies are needed to establish diagnostic protocols and explore the association between PFP and IgG4-related diseases.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"59 ","pages":"Article 102989"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-19DOI: 10.1016/j.eucr.2025.102990
Ibrahim Fathallah , Ayham Qatza , Ahmed Al-Talep , Abd Alrhman Alajrd , Ahmad Alsaede , Mohammad Oudeh Alhussien
Hydatid disease, primarily affecting liver and lungs, poses challenges with isolated renal cysts. A 29-year-old female with intermittent right flank pain and urinary burning was diagnosed with a Bosniak category 4 hydatid cyst (HC) after positive echinococcus antibodies. Imaging confirmed the diagnosis, leading to a three-month albendazole treatment followed by right nephrectomy and partial liver resection. Histopathological analysis confirmed HC and chronic pyelonephritis. The patient had an uneventful recovery and returned to normal activities. Hydatid cysts in the kidney are rare, often requiring surgical intervention for symptomatic cases. Accurate diagnosis and timely surgical intervention are crucial for effective management.
{"title":"Successful nephrectomy of isolated renal hydatid cyst associated with chronic pyelonephritis: A case report from Syria","authors":"Ibrahim Fathallah , Ayham Qatza , Ahmed Al-Talep , Abd Alrhman Alajrd , Ahmad Alsaede , Mohammad Oudeh Alhussien","doi":"10.1016/j.eucr.2025.102990","DOIUrl":"10.1016/j.eucr.2025.102990","url":null,"abstract":"<div><div>Hydatid disease, primarily affecting liver and lungs, poses challenges with isolated renal cysts. A 29-year-old female with intermittent right flank pain and urinary burning was diagnosed with a Bosniak category 4 hydatid cyst (HC) after positive echinococcus antibodies. Imaging confirmed the diagnosis, leading to a three-month albendazole treatment followed by right nephrectomy and partial liver resection. Histopathological analysis confirmed HC and chronic pyelonephritis. The patient had an uneventful recovery and returned to normal activities. Hydatid cysts in the kidney are rare, often requiring surgical intervention for symptomatic cases. Accurate diagnosis and timely surgical intervention are crucial for effective management.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"59 ","pages":"Article 102990"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report on one rare clinical case where renal tumors of different histological types occurred simultaneously. An 84-year-old male with two right renal tumors underwent radical nephrectomy. Pathology revealed chromophobe renal cell carcinoma (ChRCC) and clear cell renal cell carcinoma (ccRCC). He had a 3-year recurrence-free survival without renal function decline.
{"title":"Renal tumors with different histological types occurring in the same kidney: A case report","authors":"Maeda Akihiro , Kazuma Udo , Masahiro Ito , Maki Kawasaki , Hiroaki Kakinoki , Shohei Tobu , Mitsuru Noguchi","doi":"10.1016/j.eucr.2025.102991","DOIUrl":"10.1016/j.eucr.2025.102991","url":null,"abstract":"<div><div>We report on one rare clinical case where renal tumors of different histological types occurred simultaneously. An 84-year-old male with two right renal tumors underwent radical nephrectomy. Pathology revealed chromophobe renal cell carcinoma (ChRCC) and clear cell renal cell carcinoma (ccRCC). He had a 3-year recurrence-free survival without renal function decline.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"59 ","pages":"Article 102991"},"PeriodicalIF":0.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-17DOI: 10.1016/j.eucr.2025.102987
Anna Colarieti , Giovanni Burgio , Anna Carmen Leonetti , Davide Fabbricatore , Silvia Attanasio , Alessandro Carriero
Genitourinary tuberculosis accounts for 8–15 % of cases of extrapulmonary tuberculosis, with the testis being an infrequent site of involvement, seen in 3 % of individuals with genital tuberculosis. Testicular tuberculosis often presents with symptoms that mimic those of other testicular conditions, including neoplasms, infections and testicular torsion. We report the case of a 51-year-old male with a history of tuberculosis 11 years prior, who presented with left testicular pain, swelling, and an ulcer. Initial ultrasound findings suggested were unclear and only the histopathological examination ultimately confirmed a diagnosis of testicular tuberculosis. The patient was treated with complete clinical resolution.
{"title":"Unilateral testicular abscess: A rare manifestation of late-stage reactivation of extrapulmonary tuberculosis","authors":"Anna Colarieti , Giovanni Burgio , Anna Carmen Leonetti , Davide Fabbricatore , Silvia Attanasio , Alessandro Carriero","doi":"10.1016/j.eucr.2025.102987","DOIUrl":"10.1016/j.eucr.2025.102987","url":null,"abstract":"<div><div>Genitourinary tuberculosis accounts for 8–15 % of cases of extrapulmonary tuberculosis, with the testis being an infrequent site of involvement, seen in 3 % of individuals with genital tuberculosis. Testicular tuberculosis often presents with symptoms that mimic those of other testicular conditions, including neoplasms, infections and testicular torsion. We report the case of a 51-year-old male with a history of tuberculosis 11 years prior, who presented with left testicular pain, swelling, and an ulcer. Initial ultrasound findings suggested were unclear and only the histopathological examination ultimately confirmed a diagnosis of testicular tuberculosis. The patient was treated with complete clinical resolution.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"59 ","pages":"Article 102987"},"PeriodicalIF":0.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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