Primary prostatic sarcomas are extremely rare, accounting for less than 0.1 % of prostatic malignancies. They arise from mesenchymal stromal cells and exhibit aggressive behavior. We report a 45-year-old man with progressive lower urinary tract symptoms, abdominal distension, and weight loss. Imaging revealed a large pelvic mass inseparable from the prostate. Exploratory laparotomy showed a >30 cm encapsulated tumor, completely excised with partial prostate. Histopathology confirmed a high-grade undifferentiated sarcoma with heterologous differentiation. At two-year follow-up, the patient remained disease-free. Complete surgical excision remains the cornerstone of management, while multimodal therapy may be considered for high-risk or recurrent cases.
{"title":"High-grade undifferentiated prostatic sarcoma with heterologous differentiation: A rare case report and literature review","authors":"Abenezer Bogale Abera , Lijalem Mekonnen Geremew , Hailemaryam Shiferaw , Shiferaw Gedefa Fentie , Yasin Worku","doi":"10.1016/j.eucr.2025.103289","DOIUrl":"10.1016/j.eucr.2025.103289","url":null,"abstract":"<div><div>Primary prostatic sarcomas are extremely rare, accounting for less than 0.1 % of prostatic malignancies. They arise from mesenchymal stromal cells and exhibit aggressive behavior. We report a 45-year-old man with progressive lower urinary tract symptoms, abdominal distension, and weight loss. Imaging revealed a large pelvic mass inseparable from the prostate. Exploratory laparotomy showed a >30 cm encapsulated tumor, completely excised with partial prostate. Histopathology confirmed a high-grade undifferentiated sarcoma with heterologous differentiation. At two-year follow-up, the patient remained disease-free. Complete surgical excision remains the cornerstone of management, while multimodal therapy may be considered for high-risk or recurrent cases.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103289"},"PeriodicalIF":0.4,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-23DOI: 10.1016/j.eucr.2025.103293
Jun Yang, Yuan-Yuan Zhu, Shao-Jun Li
Xanthogranulomatous Prostatitis (XGP) is a rare benign inflammatory condition of the prostate. Patients typically present with lower urinary tract symptoms or elevated serum prostate-specific antigen (PSA) levels. Differentiating XGP from prostate cancer (PCa) based solely on multiparametric MRI (mpMRI) findings remains challenging, as histopathological examination is the gold standard for definitive diagnosis. This case report describes a 57-year-old man diagnosed with XGP. Symptomatic remission was achieved following a 4-week course of antibiotic therapy combined with an alpha-blocker.
{"title":"Xanthogranulomatous prostatitis: A case report","authors":"Jun Yang, Yuan-Yuan Zhu, Shao-Jun Li","doi":"10.1016/j.eucr.2025.103293","DOIUrl":"10.1016/j.eucr.2025.103293","url":null,"abstract":"<div><div>Xanthogranulomatous Prostatitis (XGP) is a rare benign inflammatory condition of the prostate. Patients typically present with lower urinary tract symptoms or elevated serum prostate-specific antigen (PSA) levels. Differentiating XGP from prostate cancer (PCa) based solely on multiparametric MRI (mpMRI) findings remains challenging, as histopathological examination is the gold standard for definitive diagnosis. This case report describes a 57-year-old man diagnosed with XGP. Symptomatic remission was achieved following a 4-week course of antibiotic therapy combined with an alpha-blocker.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103293"},"PeriodicalIF":0.4,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.eucr.2025.103288
Madhavan N, Balabhaskar H, Nirmal KP, Manoj Kumar G, Sunil Ashok, Manu Jose Chirayath, Rajiv S Thomas, Ritu Raj, Amal Mohan, Abraham I Thomas, Trissia Mary George
Bladder cancer in the pediatric and adolescent population is exceedingly rare.Genetic susceptibility factors, including polymorphisms in phase II detoxifying enzymes, may play a role in early tumorigenesis. We report the case of a 16-year-old male with recurrent gross hematuria, ultimately diagnosed with low-grade papillary urothelial carcinoma following transurethral resection of bladder tumor (TURBT). Genetic analysis identified a UGT1A1 polymorphism associated with reduced enzymatic activity, a known determinant of impaired detoxification, and the patient had coexistent Gilbert's syndrome. We discuss clinical presentation, management, and the potential correlation between UGT1A1 alterations, Gilbert's syndrome, environmental carcinogen exposure, and bladder carcinogenesis.
{"title":"Low-grade non–muscle-invasive urothelial carcinoma of the bladder in a 16-year-old boy with UGT1A1 polymorphism and Gilbert's syndrome: A case report","authors":"Madhavan N, Balabhaskar H, Nirmal KP, Manoj Kumar G, Sunil Ashok, Manu Jose Chirayath, Rajiv S Thomas, Ritu Raj, Amal Mohan, Abraham I Thomas, Trissia Mary George","doi":"10.1016/j.eucr.2025.103288","DOIUrl":"10.1016/j.eucr.2025.103288","url":null,"abstract":"<div><div>Bladder cancer in the pediatric and adolescent population is exceedingly rare.Genetic susceptibility factors, including polymorphisms in phase II detoxifying enzymes, may play a role in early tumorigenesis. We report the case of a 16-year-old male with recurrent gross hematuria, ultimately diagnosed with low-grade papillary urothelial carcinoma following transurethral resection of bladder tumor (TURBT). Genetic analysis identified a UGT1A1 polymorphism associated with reduced enzymatic activity, a known determinant of impaired detoxification, and the patient had coexistent Gilbert's syndrome. We discuss clinical presentation, management, and the potential correlation between UGT1A1 alterations, Gilbert's syndrome, environmental carcinogen exposure, and bladder carcinogenesis.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103288"},"PeriodicalIF":0.4,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.eucr.2025.103286
Yunfei Li , Zhuang Li , Junjie Zhu , Maohua Suo , Huaibin Qin , Zhengguang Luo , Yukun Xiao , Bensi Zhang , Xiaoyu Lv
{"title":"A rare case of scrotal vascular fibroblastoma with rapid growth: diagnostic challenges and pathological features","authors":"Yunfei Li , Zhuang Li , Junjie Zhu , Maohua Suo , Huaibin Qin , Zhengguang Luo , Yukun Xiao , Bensi Zhang , Xiaoyu Lv","doi":"10.1016/j.eucr.2025.103286","DOIUrl":"10.1016/j.eucr.2025.103286","url":null,"abstract":"","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103286"},"PeriodicalIF":0.4,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.eucr.2025.103285
Yazeid Alrefaey , Ibrahim Beshawri , Omar Shaikhomar , Ayman Younos , Mohammed Almoflihi , Salahadin Lamy
Retroperitoneal ganglioneuromas are rare, benign neural crest–derived tumors that typically occur in children and infrequently in adults. Their preoperative diagnosis is difficult due to nonspecific imaging findings, requiring histopathological confirmation. We report a 51-year-old man with an incidentally discovered retroperitoneal mass during evaluation for leukocytosis. Imaging showed a 7.8 × 4.5 × 8 cm lesion adjacent to the right kidney and duodenum. The tumor was completely excised through a robotic-assisted approach, and histopathology confirmed ganglioneuroma. This case emphasizes considering ganglioneuroma in the differential diagnosis of retroperitoneal tumors and demonstrates the feasibility and safety of robotic-assisted excision for such lesions.
{"title":"Adult retroperitoneal Ganglioneuroma: Case report of an incidental mass treated with robotic excision","authors":"Yazeid Alrefaey , Ibrahim Beshawri , Omar Shaikhomar , Ayman Younos , Mohammed Almoflihi , Salahadin Lamy","doi":"10.1016/j.eucr.2025.103285","DOIUrl":"10.1016/j.eucr.2025.103285","url":null,"abstract":"<div><div>Retroperitoneal ganglioneuromas are rare, benign neural crest–derived tumors that typically occur in children and infrequently in adults. Their preoperative diagnosis is difficult due to nonspecific imaging findings, requiring histopathological confirmation. We report a 51-year-old man with an incidentally discovered retroperitoneal mass during evaluation for leukocytosis. Imaging showed a 7.8 × 4.5 × 8 cm lesion adjacent to the right kidney and duodenum. The tumor was completely excised through a robotic-assisted approach, and histopathology confirmed ganglioneuroma. This case emphasizes considering ganglioneuroma in the differential diagnosis of retroperitoneal tumors and demonstrates the feasibility and safety of robotic-assisted excision for such lesions.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103285"},"PeriodicalIF":0.4,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.eucr.2025.103287
Miguel Gil, José Cabrita Carneiro, Luís Campos Pinheiro
Non-ischaemic priapism is a rare subtype, almost always associated with trauma. We report the case of a 26-years-old male with significant medical history of relapsing Henoch-Schönlein purpura, who presented with a painless, persistent erection for 1-week. Notably, there was no history of trauma. Nevertheless, corporal blood analysis and imaging confirmed the suspicion of non-ischaemic priapism, caused by a right intracavernosal artery fistula at the base of the penis. He underwent selective artery embolization with microcoils with immediate detumescence and no long-term sexual dysfunction.
{"title":"Non-ischaemic priapism without trauma in a patient with relapsing Henoch-Schönlein purpura","authors":"Miguel Gil, José Cabrita Carneiro, Luís Campos Pinheiro","doi":"10.1016/j.eucr.2025.103287","DOIUrl":"10.1016/j.eucr.2025.103287","url":null,"abstract":"<div><div>Non-ischaemic priapism is a rare subtype, almost always associated with trauma. We report the case of a 26-years-old male with significant medical history of relapsing Henoch-Schönlein purpura, who presented with a painless, persistent erection for 1-week. Notably, there was no history of trauma. Nevertheless, corporal blood analysis and imaging confirmed the suspicion of non-ischaemic priapism, caused by a right intracavernosal artery fistula at the base of the penis. He underwent selective artery embolization with microcoils with immediate detumescence and no long-term sexual dysfunction.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103287"},"PeriodicalIF":0.4,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.eucr.2025.103281
Lorena Vera Ubillús , Rocío Zavala Zavala, Segundo Gamboa Kcomt
We report a neovesicovaginal fistula in a woman with an ileal neobladder after radical cystectomy, caused by prolonged retention of a double-J ureteral stent that became calcified. The patient presented with continuous urinary leakage and recurrent infection. Diagnosis was confirmed by cystoscopy, methylene blue testing, and cystography. Transvaginal repair with two-layer closure and anterior vaginal wall reinforcement was performed; a Foley catheter was maintained for 21 days. Recovery was uneventful; the catheter was removed after imaging confirmed no urinary leak. This case emphasizes the need for stent surveillance and supports transvaginal repair as an effective option in selected neovesicovaginal fistulas.
{"title":"Neovesicovaginal fistula due to a retained double-J stent in an ileal neobladder: surgical management and clinical considerations","authors":"Lorena Vera Ubillús , Rocío Zavala Zavala, Segundo Gamboa Kcomt","doi":"10.1016/j.eucr.2025.103281","DOIUrl":"10.1016/j.eucr.2025.103281","url":null,"abstract":"<div><div>We report a neovesicovaginal fistula in a woman with an ileal neobladder after radical cystectomy, caused by prolonged retention of a double-J ureteral stent that became calcified. The patient presented with continuous urinary leakage and recurrent infection. Diagnosis was confirmed by cystoscopy, methylene blue testing, and cystography. Transvaginal repair with two-layer closure and anterior vaginal wall reinforcement was performed; a Foley catheter was maintained for 21 days. Recovery was uneventful; the catheter was removed after imaging confirmed no urinary leak. This case emphasizes the need for stent surveillance and supports transvaginal repair as an effective option in selected neovesicovaginal fistulas.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103281"},"PeriodicalIF":0.4,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.eucr.2025.103280
Mehdi Dadpour , Sara Besharati , Nima Saeedi , Mohammad Sajjad Zabihi , Emadoddin Hosseinjani , Mohammadreza Kamranmanesh , Reza Paeizi , Nooshin Ahmadi , Peyman Mohammadi Torbati
Juxtaglomerular cell tumor (JGCT), or reninoma, is a rare renin-secreting renal neoplasm that typically presents with severe hypertension, hypokalemia, and elevated renin and aldosterone levels. We describe an atypical case of a 21-year-old male with morbid obesity and resistant hypertension who exhibited normal biochemical findings despite the presence of a renal mass. He underwent partial nephrectomy, resulting in immediate normalization of blood pressure and subsequent regression of left ventricular hypertrophy. This case underscores the importance of considering JGCT in patients with refractory hypertension and a renal mass, even when the characteristic biochemical profile is absent.
{"title":"Atypical juxtaglomerular cell tumor in a young male with resistant hypertension and normal renin–aldosterone levels","authors":"Mehdi Dadpour , Sara Besharati , Nima Saeedi , Mohammad Sajjad Zabihi , Emadoddin Hosseinjani , Mohammadreza Kamranmanesh , Reza Paeizi , Nooshin Ahmadi , Peyman Mohammadi Torbati","doi":"10.1016/j.eucr.2025.103280","DOIUrl":"10.1016/j.eucr.2025.103280","url":null,"abstract":"<div><div>Juxtaglomerular cell tumor (JGCT), or reninoma, is a rare renin-secreting renal neoplasm that typically presents with severe hypertension, hypokalemia, and elevated renin and aldosterone levels. We describe an atypical case of a 21-year-old male with morbid obesity and resistant hypertension who exhibited normal biochemical findings despite the presence of a renal mass. He underwent partial nephrectomy, resulting in immediate normalization of blood pressure and subsequent regression of left ventricular hypertrophy. This case underscores the importance of considering JGCT in patients with refractory hypertension and a renal mass, even when the characteristic biochemical profile is absent.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103280"},"PeriodicalIF":0.4,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.eucr.2025.103282
Lianghu Chen , Qiong Lyu , Lingjie Xu , Jing Tian
A 76-year-old male, diagnosed with type 2 diabetes one year prior, was prescribed dapagliflozin. Imaging revealed perirenal effusion resembling "sweating kidneys".The exact mechanism of SGLT2 inhibitor-induced perirenal exudation remains unclear, but hypotheses include volume depletion that leads to increased renal capsule permeability, inflammation of urinary infections that extends to the kidneys, and hypersensitivity reactions that cause swelling and fluid exudation.
{"title":"“Sweating Kidneys” refers to perirenal effusion as a complication of SGLT2i: A case reports","authors":"Lianghu Chen , Qiong Lyu , Lingjie Xu , Jing Tian","doi":"10.1016/j.eucr.2025.103282","DOIUrl":"10.1016/j.eucr.2025.103282","url":null,"abstract":"<div><div>A 76-year-old male, diagnosed with type 2 diabetes one year prior, was prescribed dapagliflozin. Imaging revealed perirenal effusion resembling \"sweating kidneys\".The exact mechanism of SGLT2 inhibitor-induced perirenal exudation remains unclear, but hypotheses include volume depletion that leads to increased renal capsule permeability, inflammation of urinary infections that extends to the kidneys, and hypersensitivity reactions that cause swelling and fluid exudation.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103282"},"PeriodicalIF":0.4,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.eucr.2025.103284
Daniel I. Sanford , Alexandra Lee , Shelby Smith , Mark Sicov , Dicken S. Ko , Hsi-Yang Wu
Testicular ischemia is a urologic emergency that is most commonly caused by testicular torsion, though other etiologies have been described. We present a patient who had two separate episodes of acute testicular ischemia followed by an eventual new diagnosis of a hypercoagulable state.
{"title":"Bilateral testicular ischemia caused by heterozygous factor V Leiden","authors":"Daniel I. Sanford , Alexandra Lee , Shelby Smith , Mark Sicov , Dicken S. Ko , Hsi-Yang Wu","doi":"10.1016/j.eucr.2025.103284","DOIUrl":"10.1016/j.eucr.2025.103284","url":null,"abstract":"<div><div>Testicular ischemia is a urologic emergency that is most commonly caused by testicular torsion, though other etiologies have been described. We present a patient who had two separate episodes of acute testicular ischemia followed by an eventual new diagnosis of a hypercoagulable state.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"64 ","pages":"Article 103284"},"PeriodicalIF":0.4,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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