Nano Today最新文献_第2页

Morphology-driven UV photodetection in self-powered Pt/ZnO Schottky devices

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102754

Xiaohu Chen , Binesh Puthen Veettil , Noushin Nasiri

Emerging nanostructured materials have opened new frontiers in the design of high-performance optoelectronic devices, particularly for self-powered photodetection applications. Here, we present the novel self-powered UV photodetection capabilities of Pt/ZnO Schottky barrier devices that fabricated with two distinct ZnO morphologies: dendrite-like nanoclusters (DNCs) and nano- micro-cluster arrays (NMCAs). Both architectures demonstrate robust self-powered UV photodetection performance, albeit with significant differences in their optoelectronic behavior. The DNC-based UV photodetector (Pt/ZnO_DNCs), characterized by weak inter-nanoparticle connections and smaller structural dimensions, exhibits reduced photocurrent, higher noise levels, and non-linear photoresponse dynamics under elevated UV illumination. Conversely, the NMCA-based devices (Pt/ZnO_NMCAs), formed through capillary-driven self-assembly of DNCs using a single ethanol droplet, achieve a dramatic enhancement in performance, with a nearly thousand-fold increase in photocurrent, alongside excellent repeatability and long-term stability. Furthermore, the Pt/ZnO_NMCAs exhibit a 3.5-fold improvement in response time, with a rise time of 9.6 s compared to 51.9 s for the DNC-based variant under a UV light intensity of 2.5 mW·cm^-² in self-powered mode. These findings underscore the significant potential of NMCA-structured ZnO nanomaterials as high-performance candidates for photoconductive devices, advancing the development of self-powered optoelectronic technologies.

新兴的纳米结构材料为高性能光电器件的设计，尤其是自供电光电探测应用开辟了新的领域。在这里，我们展示了新型 Pt/ZnO 肖特基势垒器件的自供电紫外光检测能力，该器件采用两种不同的 ZnO 形态制造：树枝状纳米团簇（DNC）和纳米微团簇阵列（NMCAs）。这两种结构都显示出强大的自供电紫外光检测性能，尽管它们的光电行为存在显著差异。基于 DNC 的紫外光光电探测器（Pt/ZnODNCs）的特点是纳米粒子间的连接较弱，结构尺寸较小，在高强度紫外光照射下表现出光电流降低、噪声水平升高和非线性光响应动态。相反，基于 NMCA 的器件（Pt/ZnONMCAs）是通过使用单个乙醇液滴进行毛细管驱动的 DNC 自组装形成的，其性能显著提高，光电流增加了近千倍，同时还具有出色的可重复性和长期稳定性。此外，Pt/ZnONMCAs 的响应时间提高了 3.5 倍，在自供电模式下，紫外光强度为 2.5 mW-cm-²，上升时间为 9.6 秒，而基于 DNC 的变体为 51.9 秒。这些发现强调了 NMCA 结构氧化锌纳米材料作为光电导器件高性能候选材料的巨大潜力，推动了自供电光电技术的发展。

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引用次数: 0

Regulation of signaling pathways by metal and metal-doped nanozymes in inflammatory bowel disease: A therapeutic perspective

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102747

Mydhili Govindarasu , Jomon George Joy , Garima Sharma , Jin-Chul Kim

Inflammatory bowel disease (IBD) is a chronic condition driven by oxidative stress and dysregulated immune responses. Key pathways like nuclear factor-kappa B (NF-κB) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) play pivotal roles in IBD pathogenesis. By altering these pathways, pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β are suppressed, lowering inflammation and re-establishing immunological balance. Novel treatments for IBD have been developed using metal-based nanozymes that are designed to replicate natural enzymatic processes. These nanozymes, including iron-doped, zinc-doped, ceria-doped, transition metal-doped, and noble metal-doped variants, exhibit robust catalytic activities, such as superoxide dismutase (SOD)-like, catalase (CAT)-like, and peroxidase (POD)-like functions. By scavenging reactive oxygen species (ROS) and restoring redox balance, they mitigate oxidative stress, a key driver of IBD progression. These nanozymes interact with important signaling pathways linked to IBD in addition to their enzymatic roles. They inhibit NF-κB signaling, reducing the release of pro-inflammatory cytokines, and regulate the JAK/STAT pathway to balance immunological responses. Their therapeutic potential is increased by this dual action, which concurrently addresses immunological dysregulation and oxidative stress. Metal-doped nanozymes are a promising substitute for conventional anti-inflammatory and immunosuppressive therapies due to their precise, targeted action. The review article explores the latest developments in metal based nanozyme research, their catalytic characteristics, and how they affect IBD treatment, as well as potential future paths for the area.

{"title":"Regulation of signaling pathways by metal and metal-doped nanozymes in inflammatory bowel disease: A therapeutic perspective","authors":"Mydhili Govindarasu , Jomon George Joy , Garima Sharma , Jin-Chul Kim","doi":"10.1016/j.nantod.2025.102747","DOIUrl":"10.1016/j.nantod.2025.102747","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is a chronic condition driven by oxidative stress and dysregulated immune responses. Key pathways like nuclear factor-kappa B (NF-κB) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) play pivotal roles in IBD pathogenesis. By altering these pathways, pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β are suppressed, lowering inflammation and re-establishing immunological balance. Novel treatments for IBD have been developed using metal-based nanozymes that are designed to replicate natural enzymatic processes. These nanozymes, including iron-doped, zinc-doped, ceria-doped, transition metal-doped, and noble metal-doped variants, exhibit robust catalytic activities, such as superoxide dismutase (SOD)-like, catalase (CAT)-like, and peroxidase (POD)-like functions. By scavenging reactive oxygen species (ROS) and restoring redox balance, they mitigate oxidative stress, a key driver of IBD progression. These nanozymes interact with important signaling pathways linked to IBD in addition to their enzymatic roles. They inhibit NF-κB signaling, reducing the release of pro-inflammatory cytokines, and regulate the JAK/STAT pathway to balance immunological responses. Their therapeutic potential is increased by this dual action, which concurrently addresses immunological dysregulation and oxidative stress. Metal-doped nanozymes are a promising substitute for conventional anti-inflammatory and immunosuppressive therapies due to their precise, targeted action. The review article explores the latest developments in metal based nanozyme research, their catalytic characteristics, and how they affect IBD treatment, as well as potential future paths for the area.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102747"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Administration route-commended concise organ-selective mRNA transfection (ACCOST) by cyclic disulfide-primed short polyethylenimine

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102741

Ruonan Ye , Qiongzhe Ren , Limin Chang , Siqi Zhang , Changchang Deng , Li Cao , Meng Shi , Bo Lou , Fenghua Meng , Shi Du , Keyun Ren , Xijun Piao , Congcong Xu , Zhiyuan Zhong

mRNA technology holds great promise for addressing a spectrum of diseases. Achieving widespread clinical utility of mRNA therapeutics requires effective transfection of mRNA to specific organs. Here we introduce a cyclic disulfide-primed short polyethyleneimine (CD-PEI) polymer that demonstrates administration route-commended concise organ-selective mRNA transfection (ACCOST) in vivo. The cyclic disulfide groups on the PEI polymer facilitate thiol-mediated cytosolic mRNA delivery and high transfection of different types of cells including hard-to-transfect immune cells. Remarkably, CD-PEI-mRNA complex achieves nearly 100 % organ-specific transfection in pancreas, lymph nodes, brain/spinal cord, and spleen via intraperitoneal, subcutaneous, intrathecal injection, and intravenous injections, respectively, with negligible accumulation in non-target organs. The intravenous injection to pregnant mice results in selective mRNA expression in the placenta instead. The spleen targeting occurs likely via erythrocyte-hijacking mechanism and systemically administered mRNA vaccines elicit robust antigen-specific anti-tumor immunity in murine B16-OVA model. Therefore, our ACCOST technology presents a novel strategy for organ-specific mRNA transfection.

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引用次数: 0

Visualizing the substrate-dependent structural evolution of Na2WO4 via in-situ transmission electron microscopy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102751

Kunkun Wei , Yutao Ren , Yilin Zhao , Fangwei Liu , Xutao Chen , Yue Wang , Shihui Zou , Chengyuan Liu , Yang Pan , Jianguo Huang , Wentao Yuan , Zhongkang Han , Yong Wang , Jie Fan

Supported nanocatalysts often undergo sintering at elevated temperatures, whereas the dispersion of large particles into small particles is uncommon. Here, we discover that Na₂WO₄ evolves from large bulk particles to evenly distributed high-concentration nanoclusters on the ZrO₂ surface but remains as large particles on the TiO₂ surface at high temperatures. This substrate-dependent structural evolution is visualized by in-situ transmission electron microscopy and rationalized by the differing interactions between Na₂WO₄ and the substrates. The great potential of this substrate-dependent structural evolution in developing advanced Na₂WO₄ cluster catalysts is demonstrated using methyl chloride-to-vinyl chloride as a probe reaction. Benefiting from the presence of high-concentration Na₂WO₄ nanoclusters that effectively couple ·CH₂Cl radicals, Na₂WO₄/ZrO₂ exhibits a C₂H₃Cl selectivity of 31.9 % and a yield of 20.0 % at 700 °C, which is much higher than those of Na₂WO₄/TiO₂.

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引用次数: 0

A nuclei bombing nano-system improves STING-activated cancer immunotherapy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102749

Shuai Guo , Tianwang Guan , Rundong Tai , Long Ma , Yushen Ke , Jujian Ye , Huiwan Chen , Yuxuan Pan , Xiaodong Ning , Xueqin Shi , Zhilin Deng , Yafang Xiao , Shaohui Deng , Peier Chen , Zhenhua Li , Xiaozhong Qiu , Kelong Fan , Zheyu Shen , Caiwen Ou

The activation of the stimulator of interferon genes (STING) pathway presents a promising therapeutic strategy for pancreatic cancer by enhancing immune responses and reprogramming the immunosuppressive tumor microenvironment (TME). Ferroptosis, an iron-dependent form of cell death, can synergize with STING activation through reactive oxygen species (ROS)-induced DNA damage. However, its efficacy is hindered by poor vascularization, inefficient delivery of STING agonists, and tumor resistance mechanisms that suppress ROS levels. To overcome these limitations, we developed a "nuclei bombing" nano-system using extremely small cuprous oxide modified magneto-human heavy chain ferritin (ES-CO@M-HFn). This system targets pancreatic cancer cells overexpressing transferrin receptor 1 (TfR1) and releases Cu⁺ and Fe³⁺ ions in response to the acidic (pH 6.8) and glutathione (GSH)-rich TME. These ions form a Cu-Fe catalytic cycle under high H₂O₂ levels, continuously generating Fe²⁺, Cu⁺, and robust ROS, thereby inducing ferroptosis and cuproptosis. This creates a synergistic feedback loop that amplifies oxidative damage, leading to extensive DNA damage and tumor cell destruction—termed the "nuclei bombing" effect. The resulting DNA fragments activate the STING pathway, reprogramming the TME by maturing dendritic cells, repolarizing macrophages, and activating CD8⁺ T cells. This comprehensive approach generates a potent immune response, significantly suppressing tumor growth and metastasis, and offers a transformative strategy for pancreatic cancer treatment.

{"title":"A nuclei bombing nano-system improves STING-activated cancer immunotherapy","authors":"Shuai Guo , Tianwang Guan , Rundong Tai , Long Ma , Yushen Ke , Jujian Ye , Huiwan Chen , Yuxuan Pan , Xiaodong Ning , Xueqin Shi , Zhilin Deng , Yafang Xiao , Shaohui Deng , Peier Chen , Zhenhua Li , Xiaozhong Qiu , Kelong Fan , Zheyu Shen , Caiwen Ou","doi":"10.1016/j.nantod.2025.102749","DOIUrl":"10.1016/j.nantod.2025.102749","url":null,"abstract":"<div><div>The activation of the stimulator of interferon genes (STING) pathway presents a promising therapeutic strategy for pancreatic cancer by enhancing immune responses and reprogramming the immunosuppressive tumor microenvironment (TME). Ferroptosis, an iron-dependent form of cell death, can synergize with STING activation through reactive oxygen species (ROS)-induced DNA damage. However, its efficacy is hindered by poor vascularization, inefficient delivery of STING agonists, and tumor resistance mechanisms that suppress ROS levels. To overcome these limitations, we developed a \"nuclei bombing\" nano-system using extremely small cuprous oxide modified magneto-human heavy chain ferritin (ES-CO@M-HFn). This system targets pancreatic cancer cells overexpressing transferrin receptor 1 (TfR1) and releases Cu<sup>+</sup> and Fe<sup>3+</sup> ions in response to the acidic (pH 6.8) and glutathione (GSH)-rich TME. These ions form a Cu-Fe catalytic cycle under high H₂O₂ levels, continuously generating Fe<sup>2+</sup>, Cu<sup>+</sup>, and robust ROS, thereby inducing ferroptosis and cuproptosis. This creates a synergistic feedback loop that amplifies oxidative damage, leading to extensive DNA damage and tumor cell destruction—termed the \"nuclei bombing\" effect. The resulting DNA fragments activate the STING pathway, reprogramming the TME by maturing dendritic cells, repolarizing macrophages, and activating CD8<sup>+</sup> T cells. This comprehensive approach generates a potent immune response, significantly suppressing tumor growth and metastasis, and offers a transformative strategy for pancreatic cancer treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102749"},"PeriodicalIF":13.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The peptide-Au clusters inhibit EGFR exon 19 deletion mutant non-small cell lung cancer

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-05 DOI: 10.1016/j.nantod.2025.102744

Wencong Zhao , Wendi Huo , Haoran Dang , Zhongying Du , Qing Yuan , Kai Cao , Xueyun Gao

Epidermal growth factor receptor (EGFR) exon 19 deletions are a common mutation that can lead to non-small cell lung cancer (NSCLC). Here, we designed and synthesized Au clusters coated with EGFR-target peptides to treat EGFR exon 19 deletions mutated NSCLC. Two sequences of peptides (namely P1 and P2 peptide) were designed for synthesis two Au clusters (namely P1-Au and P2-Au), respectively. These two clusters specifically target the extracellular region of EGFR and enter cancer cells through endocytosis. ICP-MS measurements, enzyme activity experiments and cytotoxicity studies in H1650 cells (exon 19 deletions of EGFR) demonstrated that P1-Au clusters have stronger targeting ability towards EGFR, well inhibits EGFR phosphorylation and outcome a better anti-tumor effect than that of P2-Au clusters. Further experiments revealed that the P1-Au clusters enter H1650 cells through the clathrin-mediated endocytosis pathway, escape from lysosomes to the cytoplasm, and inhibit the phosphorylation of EGFR exon 19 deletions and its downstream protein to induce cancer cell apoptosis. P1-Au clusters significantly inhibited the tumor growth in an H1650 xenograft model via suppress EGFR exon 19 deletions mutant activation.

表皮生长因子受体（EGFR）19外显子缺失是一种常见的突变，可导致非小细胞肺癌（NSCLC）。在此，我们设计并合成了涂有表皮生长因子受体靶向肽的金簇，用于治疗表皮生长因子受体19外显子缺失突变的非小细胞肺癌。我们设计了两种肽序列（即 P1 肽和 P2 肽），分别用于合成两个金簇（即 P1-Au 和 P2-Au）。这两个金簇特异性地靶向表皮生长因子受体的胞外区域，并通过内吞作用进入癌细胞。ICP-MS测量、酶活性实验以及对H1650细胞（表皮生长因子受体19外显子缺失）的细胞毒性研究表明，P1-Au簇对表皮生长因子受体的靶向能力更强，能很好地抑制表皮生长因子受体的磷酸化，抗肿瘤效果优于P2-Au簇。进一步的实验发现，P1-Au 簇通过凝集素介导的内吞途径进入 H1650 细胞，从溶酶体逸出到细胞质，抑制表皮生长因子受体 19 外显子缺失及其下游蛋白的磷酸化，从而诱导癌细胞凋亡。P1-Au 簇通过抑制表皮生长因子受体 19 号外显子缺失突变体的活化，显著抑制了 H1650 异种移植模型的肿瘤生长。

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引用次数: 0

Harnessing Zn-volatility for compositional tuning in PtZn nanoalloy catalysts

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-04 DOI: 10.1016/j.nantod.2025.102746

Bingqing Yao , Chaokai Xu , Yaxin Tang , Yankun Du , Shengdong Tan , Sheng Dai , Guangfu Luo , Qian He

Bimetallic nanoalloys have gained extensive attention due to their tunable properties and wide range of catalytic applications. However, achieving good compositional control in nanoalloy catalysts remains a formidable challenge. In this work, we demonstrate that heat treatment can be used to tune the composition of Pt-Zn nanoalloy catalysts, leveraging the volatile nature of zinc to enhance their performance in propane dehydrogenation. Through identical location scanning transmission electron microscopy (IL-STEM) using an in situ gas cell, as well as other complementary techniques, we observed that the zinc content of the Pt-Zn nanoalloy particles can be tuned via heat treatment under hydrogen. The extent of change appeared to be influenced by experimental details such as the original composition of the particles, as well as heat treatment conditions such as temperature and flow rate. Our experimental results, supported by theoretical calculations, suggest that Zn volatilization can be controlled when the alloys reach certain compositions such as the intermetallic phase. This approach offers a new strategy for developing better Pt-Zn catalysts.

{"title":"Harnessing Zn-volatility for compositional tuning in PtZn nanoalloy catalysts","authors":"Bingqing Yao , Chaokai Xu , Yaxin Tang , Yankun Du , Shengdong Tan , Sheng Dai , Guangfu Luo , Qian He","doi":"10.1016/j.nantod.2025.102746","DOIUrl":"10.1016/j.nantod.2025.102746","url":null,"abstract":"<div><div>Bimetallic nanoalloys have gained extensive attention due to their tunable properties and wide range of catalytic applications. However, achieving good compositional control in nanoalloy catalysts remains a formidable challenge. In this work, we demonstrate that heat treatment can be used to tune the composition of Pt-Zn nanoalloy catalysts, leveraging the volatile nature of zinc to enhance their performance in propane dehydrogenation. Through identical location scanning transmission electron microscopy (IL-STEM) using an <em>in situ</em> gas cell, as well as other complementary techniques, we observed that the zinc content of the Pt-Zn nanoalloy particles can be tuned <em>via</em> heat treatment under hydrogen. The extent of change appeared to be influenced by experimental details such as the original composition of the particles, as well as heat treatment conditions such as temperature and flow rate. Our experimental results, supported by theoretical calculations, suggest that Zn volatilization can be controlled when the alloys reach certain compositions such as the intermetallic phase. This approach offers a new strategy for developing better Pt-Zn catalysts.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102746"},"PeriodicalIF":13.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building high-contrast afterglow nanoprobe using semiconducting polymer nanoparticles and CuRu nanozyme for prolonged surgical navigation

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-04 DOI: 10.1016/j.nantod.2025.102750

Di Zhao , Aifang Zhou , Tengfei Zhang , Chen Han , Hong-Min Meng , Yuehe Lin , Zhaohui Li

Precise real-time imaging of tumor boundary is critical for effectively and thoroughly eliminating tumor residuals during surgery to prevent recurrence. Organic afterglow luminescent probes, well known for their high signal-to-background ratio (SBR), are particularly promising for imaging in vivo. However, current afterglow imaging systems still face limitations in surgical navigation: "always-on" probes offer poor contrast between the tumor area and surrounding normal tissues, and lack the enduring imaging capability needed for complete tumor excision. In this work, we developed a novel tumor microenvironment-activated afterglow nanoprobe, denoted as FMCR, by integrating the semiconducting polymer 2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene (MEHPPV) with CuRu nanozyme for enhanced intravital afterglow imaging. The CuRu nanozyme component of FMCR exhibits robust catalase-like activity, continuously catalyzing the conversion of overexpressed hydrogen peroxide (H₂O₂) present in the tumor microenvironment to oxygen (O₂), which increased the aerobic afterglow signal distinctly. More importantly, this CuRu nanozyme could sustainably and stably produce O₂ by catalyzing endogenous H₂O₂ over the long term, greatly prolonging the decay time of afterglow imaging. In vivo experiments revealed that FMCR facilitated the imaging of subcutaneously xenografted 4T1 tumors in living mice, with a remarkable SBR of 20.18. Furthermore, guided by afterglow imaging of FMCR, surgery was performed to effectively remove intraperitoneal tumor nodules, including those as smaller as 2–4.5 mm in diameter, which demonstrated the immense potential of FMCR for precise surgical navigation.

{"title":"Building high-contrast afterglow nanoprobe using semiconducting polymer nanoparticles and CuRu nanozyme for prolonged surgical navigation","authors":"Di Zhao , Aifang Zhou , Tengfei Zhang , Chen Han , Hong-Min Meng , Yuehe Lin , Zhaohui Li","doi":"10.1016/j.nantod.2025.102750","DOIUrl":"10.1016/j.nantod.2025.102750","url":null,"abstract":"<div><div>Precise real-time imaging of tumor boundary is critical for effectively and thoroughly eliminating tumor residuals during surgery to prevent recurrence. Organic afterglow luminescent probes, well known for their high signal-to-background ratio (SBR), are particularly promising for imaging <em>in vivo</em>. However, current afterglow imaging systems still face limitations in surgical navigation: \"always-on\" probes offer poor contrast between the tumor area and surrounding normal tissues, and lack the enduring imaging capability needed for complete tumor excision. In this work, we developed a novel tumor microenvironment-activated afterglow nanoprobe, denoted as FMCR, by integrating the semiconducting polymer 2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene (MEHPPV) with CuRu nanozyme for enhanced intravital afterglow imaging. The CuRu nanozyme component of FMCR exhibits robust catalase-like activity, continuously catalyzing the conversion of overexpressed hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) present in the tumor microenvironment to oxygen (O<sub>2</sub>), which increased the aerobic afterglow signal distinctly. More importantly, this CuRu nanozyme could sustainably and stably produce O<sub>2</sub> by catalyzing endogenous H<sub>2</sub>O<sub>2</sub> over the long term, greatly prolonging the decay time of afterglow imaging. <em>In vivo</em> experiments revealed that FMCR facilitated the imaging of subcutaneously xenografted 4T1 tumors in living mice, with a remarkable SBR of 20.18. Furthermore, guided by afterglow imaging of FMCR, surgery was performed to effectively remove intraperitoneal tumor nodules, including those as smaller as 2–4.5 mm in diameter, which demonstrated the immense potential of FMCR for precise surgical navigation.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102750"},"PeriodicalIF":13.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal endothelial dysfunction treatments: Recent advances in non-invasive treatment strategies

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-02 DOI: 10.1016/j.nantod.2025.102740

Nataliia Gnyliukh , Rabah Boukherroub , Sabine Szunerits

The corneal endothelium plays an essential role in the maintenance of a healthy vision. However, in contrast to epithelial cells with high proliferation rates and a turnover lifespan of six to seven days that allows maintenance of constant cell density and high control of cell adhesion, human corneal endothelial cells (HCECs) do not normally proliferate. Therefore, loss of HCECs density over time leads to corneal transparency loss, and the development of corneal edema, bullous keratopathy and other eye diseases. Developments for repairing HCECs are continuously searched for and are evolving around possible topical drug applications as well as emerging strategies such as CRISPR-Cas9 gene editing, antisense oligonucleotides (ASOs) and nanotechnological concepts. Here, the state-of-the-art treatment strategies for corneal endothelial diseases (e.g. Fuch's endothelial corneal dystrophy (FECD), corneal edema, bullous keratopathy) will be outlined with a special focus on where topical applications have shown positive therapeutic outcomes.

引用次数: 0

Integrating autophagy inhibition and ROS clearance in biohybrid nanoparticles for low-temperature cancer photothermal therapy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-04-02 DOI: 10.1016/j.nantod.2025.102737

Suleixin Yang , Ruie Chen , Peng Hua , Yi Wu , Meiwan Chen

Photothermal therapy (PTT) demands efficient cancer ablation at relative low temperatures and minimal thermal damage to normal tissues, but suffers from both the protective autophagy-related thermal resistance in cancer cell and reactive oxygen species (ROS)-induced damage to normal cells. Here, we screened out curcumin-Fe ultrasmall nanoparticles (Cur-Fe) that manifested efficient photothermal conversion efficiency (η = 43.38 %) and ROS scavenging ability. Additionally, CRISPR/Cas9 plasmids (pCas-ATG5/ATG7) were also constructed to safely and precisely knockdown the protective autophagy for thermal resistance alleviation. The core Cur-Fe/ATG@^TKPF (CFA@T), which was composed of anionic Cur-Fe and pCas-ATGs, was encapsulated by cationic thioketal-crosslinked and fluorinated polyethyleneimine (^TKPF) via electrostatic interaction. Further, CFA@TC was formed by CFA@T coated with an acidic pH-responsive shell OHC-PEG-CHO via Schiff base. Attributed to its dual responsiveness to pH and ROS, CFA@TC exhibited efficient tumor targeting and uptake following intravenous injection. Upon irradiation with a 652 nm laser, CFA@TC demonstrated enhanced efficacy in eradicating cancer cells by inhibiting autophagy, while concurrently mitigating inflammatory responses through intracellular ROS scavenging in vivo and in vitro. Taken together, our study provides a proof-of-concept that CRISPR can be effective for autophagy inhibition, and its integration with ROS-induced inflammatory responses relief can further improve PTT.

{"title":"Integrating autophagy inhibition and ROS clearance in biohybrid nanoparticles for low-temperature cancer photothermal therapy","authors":"Suleixin Yang , Ruie Chen , Peng Hua , Yi Wu , Meiwan Chen","doi":"10.1016/j.nantod.2025.102737","DOIUrl":"10.1016/j.nantod.2025.102737","url":null,"abstract":"<div><div>Photothermal therapy (PTT) demands efficient cancer ablation at relative low temperatures and minimal thermal damage to normal tissues, but suffers from both the protective autophagy-related thermal resistance in cancer cell and reactive oxygen species (ROS)-induced damage to normal cells. Here, we screened out curcumin-Fe ultrasmall nanoparticles (Cur-Fe) that manifested efficient photothermal conversion efficiency (η = 43.38 %) and ROS scavenging ability. Additionally, CRISPR/Cas9 plasmids (pCas-ATG5/ATG7) were also constructed to safely and precisely knockdown the protective autophagy for thermal resistance alleviation. The core Cur-Fe/ATG@<sup>TK</sup>PF (CFA@T), which was composed of anionic <u>C</u>ur-<u>F</u>e and pCas-<u>A</u>TGs, was encapsulated by cationic thioketal-crosslinked and fluorinated polyethyleneimine (<sup><u>T</u>K</sup>PF) via electrostatic interaction. Further, CFA@TC was formed by CFA@T coated with an acidic pH-responsive shell OH<u>C</u>-PEG-CHO via Schiff base. Attributed to its dual responsiveness to pH and ROS, CFA@TC exhibited efficient tumor targeting and uptake following intravenous injection. Upon irradiation with a 652 nm laser, CFA@TC demonstrated enhanced efficacy in eradicating cancer cells by inhibiting autophagy, while concurrently mitigating inflammatory responses through intracellular ROS scavenging <em>in vivo</em> and <em>in vitro</em>. Taken together, our study provides a proof-of-concept that CRISPR can be effective for autophagy inhibition, and its integration with ROS-induced inflammatory responses relief can further improve PTT.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"63 ","pages":"Article 102737"},"PeriodicalIF":13.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0