Nano Today最新文献_第2页

Modular arborized fog harvesting device with coordinated mechanism of capture and transport 具有捕捉和运输协调机制的模块化芯轴采雾装置

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-23 DOI: 10.1016/j.nantod.2024.102557

Huayang Zhang , Shangzhen Xie , Guangyi Tian , Yihang Zhang , Zhiguang Guo

With global water scarcity a growing problem, fog harvesting technology has emerged as an effective solution. Industrial development and population growth have exacerbated the need for efficient, dismantlable, and assembled fog harvesting devices, as well as the requirement to optimize the droplet capture-transport relationship. In this study, a novel modular bionic 3D tree-like structure for fog harvesting system (3D-TSFHS) was developed to achieve rapid droplet transport by means of Nepenthes-inspired superslip leaves (SSLs). In addition, aluminum (Al) cones with superhydrophilic and superhydrophobic (SHL-SHB) patterns were prepared to enhance the droplet capture efficiency by drawing on the special wettability and structural features of various plants and animals such as cactus, spider silk, desert beetles, lizards and camphor leaves. This artificial design significantly enhances the overall capture and transport relationship. The resulting embedded superslip leaves Al cone fog harvesting (E-SLAC-FH) dramatically improves the fog harvesting efficiency and exhibits excellent durability. Assembling this fog harvesting into a 3D-TSFHS achieves a high fog harvesting efficiency of 0.462 g∙cm⁻²∙min⁻¹. The system's modular design and its exceptional durability ensure its potential for a wide range of applications in a variety of real-world scenarios.

随着全球缺水问题日益严重，雾收集技术已成为一种有效的解决方案。工业发展和人口增长加剧了对高效、可拆卸、可组装的雾收集装置的需求，同时也提出了优化液滴捕获-传输关系的要求。本研究开发了一种新颖的模块化仿生三维树状结构雾收集系统（3D-TSFHS），通过受尼芬切斯启发的超滑叶（SSL）实现雾滴的快速传输。此外，还利用仙人掌、蜘蛛丝、沙漠甲虫、蜥蜴和樟树叶等各种动植物的特殊润湿性和结构特征，制备了具有超亲水和超疏水（SHL-SHB）图案的铝（Al）锥体，以提高液滴捕获效率。这种人工设计大大增强了整体捕捉和传输关系。由此产生的嵌入式超滑动叶片 Al cone 收雾器（E-SLAC-FH）极大地提高了收雾效率，并表现出卓越的耐用性。将这种雾收集装置组装到三维-TSFHS 中，可实现 0.462 g∙cm-2∙min-1 的高雾收集效率。该系统的模块化设计和卓越的耐用性确保了其在各种实际应用场景中的广泛应用潜力。

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引用次数: 0

Therapeutic advances of magnetic nanomaterials in chronic wound healing 磁性纳米材料在慢性伤口愈合方面的治疗进展

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-23 DOI: 10.1016/j.nantod.2024.102554

Jingyi Li , Yaqi Yang , Guofang Zhang , Jianfei Sun , Yang Li , Bing Song

Millions of patients worldwide suffer from chronic and non-healing wounds, leading to hospitalizations, infections, and even fatalities. Despite advances in clinical therapies, wound management remains a significant challenge due to the complex wound environment and increasing antibiotic resistance. Consequently, there is an urgent need for innovative strategies to address chronic wound treatment. Among the emerging approaches, nanomaterial-based therapeutic systems, especially magnetically responsive strategies, are gaining considerable attention. Upon exposure to an external magnetic field, magnetic nanomaterials (MNMs) can induce electromagnetic, magnetothermal, and magnetomechanical effects at the wound site. Additionally, compared with other exogenous stimuli-responsive therapies, magnetic fields offer distinct advantages, including non-invasiveness, deep tissue penetration, and high sensitivity for remote control and actuation of cells. In this review, we first outline the fundamental properties, design strategies, and biological mechanisms of MNMs and discuss their various applications in chronic wound therapy, such as antibacterial effects, magnetothermal therapy, controlled drug delivery, mechanical cell manipulation, wireless electrical stimulation, and dual-stimulation approaches. We then highlight recent advancements in MNMs for wound monitoring and management, including magnetic nanorobots and “smart dressings”. Finally, we offer our insights on the current challenges of MNMs and propose future directions to enhance their clinical translation. Overall, this review emphasizes the potential of magnetic nanomaterial-based therapeutic systems to transform the landscape of chronic wound management.

全世界有数百万患者患有慢性伤口和伤口不愈合，导致住院、感染甚至死亡。尽管临床疗法不断进步，但由于伤口环境复杂和抗生素耐药性不断增加，伤口管理仍然是一项重大挑战。因此，迫切需要创新的策略来解决慢性伤口治疗问题。在新出现的方法中，基于纳米材料的治疗系统，尤其是磁响应策略，正受到广泛关注。暴露于外部磁场时，磁性纳米材料（MNM）可在伤口部位诱发电磁、磁热和磁力学效应。此外，与其他外源性刺激响应疗法相比，磁场具有独特的优势，包括非侵入性、深层组织穿透性以及远程控制和驱动细胞的高灵敏度。在这篇综述中，我们首先概述了 MNM 的基本特性、设计策略和生物机制，并讨论了它们在慢性伤口治疗中的各种应用，如抗菌效果、磁热疗法、可控药物输送、机械细胞操纵、无线电刺激和双重刺激方法。然后，我们重点介绍了磁性纳米机器人和 "智能敷料 "等磁性纳米材料在伤口监测和管理方面的最新进展。最后，我们就目前磁性纳米机器人所面临的挑战发表了自己的见解，并提出了加强其临床应用的未来方向。总之，本综述强调了基于磁性纳米材料的治疗系统改变慢性伤口管理格局的潜力。

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引用次数: 0

Breaking biological barriers: Engineering polymeric nanoparticles for cancer therapy 打破生物障碍：用于癌症治疗的工程聚合物纳米粒子

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-22 DOI: 10.1016/j.nantod.2024.102552

Elmer Austria Jr. , Marcela Bilek , Pegah Varamini , Behnam Akhavan

Polymeric nanoparticles (PNPs) have evolved over the past few decades as promising vehicles to deliver drugs to treat cancer. However, their clinical application remains limited mainly due to several biological obstacles. These include rapid clearance from the bloodstream, complex hemorheological dynamics, suboptimal biodistribution, limited tumor accumulation and extravasation, inefficient cellular internalization and trafficking, and offsite toxicity. How can we carefully tune the physicochemical properties of PNPs to break these barriers? This review answers this question by comprehensively and critically examining recent advances and trends in engineering the physicochemical properties of PNPs to enhance their efficacy in cancer drug delivery. It sheds light on the underpinning mechanisms regulated by size, shape, and surface chemistry critical in overcoming heterogeneous biological barriers. Synergistic effects and the interplay between these physicochemical properties are discussed in detail. The types of PNPs, based on form, morphology, and fabrication strategies, are critically reviewed and evaluated according to their physicochemical properties, which directly impact the efficacy of the drug delivery systems and their fate upon administration. The review concludes by proposing design principles and future research directions to enhance the clinical translation of PNPs and their advancement towards more effective cancer treatments.

过去几十年来，聚合纳米粒子（PNPs）已发展成为治疗癌症的药物输送载体，前景广阔。然而，它们的临床应用仍然受到限制，主要原因是存在一些生物学障碍。这些障碍包括：从血液中快速清除、复杂的血液流变动力学、生物分布不理想、肿瘤蓄积和外渗有限、细胞内化和贩运效率低下以及异地毒性。我们如何才能精心调整 PNPs 的理化特性以打破这些障碍？这篇综述通过全面、批判性地研究 PNPs 理化特性工程学的最新进展和趋势来回答这个问题，从而提高其在癌症药物递送中的功效。它揭示了由尺寸、形状和表面化学调控的、对克服异质性生物障碍至关重要的基础机制。报告详细讨论了这些物理化学特性之间的协同效应和相互作用。根据 PNPs 的形式、形态和制造策略，对 PNPs 的类型进行了批判性的评论，并根据其理化特性对其进行了评估，这些理化特性直接影响到给药系统的药效和给药后的转归。综述最后提出了设计原则和未来研究方向，以加强 PNPs 的临床转化，推动其向更有效的癌症治疗方向发展。

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引用次数: 0

Mixed ion-electron conductive materials: A path to higher energy density all-solid-state lithium-ion batteries 混合离子电子导电材料：通往能量密度更高的全固态锂离子电池之路

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-22 DOI: 10.1016/j.nantod.2024.102556

Abdulkadir Kızılaslan , Recep Kızılaslan , Akira Miura , Kiyoharu Tadanaga

The cathode of conventional lithium-ion batteries(LIBs) consist of three components including active materials, binders, and electron conductive agents. Binders and conductive agents, which are not directly involved in Faradaic reactions, should be minimized to incorporate more active materials into the electrode. Unlike conventional LIBs, in all-solid-state batteries(ASSBs) - considered as the next-generation batteries-, there is no liquid electrolyte to impart ionic conductivity through wetting the electrodes. Therefore, cathodes for ASSBs require both ion and electron-conducting additives to facilitate charge transport which complicates the preparation of the cathode with intimate triple contact between active material, ion conductive agent and electron conductive agent. In this perspective, mixed ion-electron conductive(MIEC) materials can be regarded as intrinsic ion-electron conductors for electrodes to ease the cathode preparation, boost gravimetric/volumetric energy density, and dig the path to monocomponent electrodes -solely active materials-. This review covers the potential of MIEC materials to be utilized as active material, binder, interlayer, and conductive scaffold to boost the electrochemical performance of solid-state LIBs. Besides, the potential of ASSBs with monocomponent electrodes was evaluated from the perspective of MIEC materials. Moreover, the feasibility of 2D structures were evaluated as MIEC materials for the ASSB electrodes. The concept of MIEC was not be confined to intrinsic MIEC materials but the materials that turned into MIEC by compositing, doping or heat-treatment were considered as MIEC materials in this study.

传统锂离子电池（LIBs）的阴极由活性材料、粘合剂和电子导电剂三部分组成。粘合剂和导电剂不直接参与法拉第反应，应尽量减少使用，以便在电极中加入更多活性材料。与传统 LIB 不同，被视为下一代电池的全固态电池（ASSB）中没有液态电解质通过润湿电极来赋予离子导电性。因此，全固态电池的阴极需要同时使用离子导电添加剂和电子导电添加剂来促进电荷传输，这使得制备活性材料、离子导电剂和电子导电剂三者紧密接触的阴极变得更加复杂。从这个角度来看，离子电子混合导电（MIEC）材料可被视为电极的固有离子电子导体，从而简化阴极制备过程，提高重力/体积能量密度，并为单组分电极--纯活性材料--开辟道路。本综述介绍了 MIEC 材料作为活性材料、粘合剂、夹层和导电支架来提高固态 LIB 电化学性能的潜力。此外，还从 MIEC 材料的角度评估了单组分电极 ASSB 的潜力。此外，还评估了二维结构作为 ASSB 电极 MIEC 材料的可行性。在本研究中，MIEC 的概念并不局限于固有的 MIEC 材料，通过复合、掺杂或热处理变成 MIEC 的材料也被视为 MIEC 材料。

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引用次数: 0

Smart hydrogel dressing for machine learning-enabled visual monitoring and promote diabetic wound healing 智能水凝胶敷料可通过机器学习进行视觉监控，促进糖尿病伤口愈合

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-22 DOI: 10.1016/j.nantod.2024.102559

Duanyu Deng , Lihua Liang , Kaize Su , Han Gu , Xu Wang , Yan Wang , Xiangcun Shang , Wenhuan Huang , Henghui Chen , Xiaoxian Wu , Wing-Leung Wong , Dongli Li , Kun Zhang , Panpan Wu , Keke Wu

Diabetic wounds are complex complications characterized by long-term chronic inflammation, vascular damage, and difficulties in healing. Monitoring wound pH can serve as an early warning system for infection risk and enhance wound management by tracking changes in wound pH. In this study, a machine learning-assisted analysis smart hydrogel as wound dressing was developed by utilizing a double cross-linked network hydrogel of gelatin methacrylate (GelMA) and chitosan methacrylate (CMCSMA) as the matrix, a compound of cobalt-gallic acid based metal-phenolic nanoparticles (GACo MPNs) as the active ingredients, and phenol red as the pH indicator. This smart hydrogel exhibits excellent injection performance, shape adaptability and mechanical strength. Besides, a series of in vitro experiments demonstrated the favorable biocompatibility and bioactivity of GelMA/CMCSMAP-GACo hydrogel, encompassing its antibacterial, anti-inflammatory, antioxidant, and angiogenic properties. In vivo experiments show that this hydrogel significantly improved the repair of diabetic wounds in mice. Interestingly, the hydrogel exhibited unique visual pH monitoring properties, which can be seamlessly integrated with a smartphone for image visualization and further enable reliable wound pH assessment using machine learning algorithms to enhance wound management based on wound pH. Overall, this study presented a comprehensive regenerative strategy for the management of diabetic wounds.

糖尿病伤口是一种复杂的并发症，其特点是长期慢性炎症、血管损伤和愈合困难。监测伤口 pH 值可作为感染风险的早期预警系统，并通过跟踪伤口 pH 值的变化加强伤口管理。本研究以甲基丙烯酸明胶（GelMA）和甲基丙烯酸壳聚糖（CMCSMA）的双交联网络水凝胶为基质，以金属酚纳米颗粒（GACo MPNs）为活性成分，以酚红为 pH 指示剂，开发了一种机器学习辅助分析智能水凝胶伤口敷料。这种智能水凝胶具有优异的注射性能、形状适应性和机械强度。此外，一系列体外实验表明，GelMA/CMCSMAP-GACo 水凝胶具有良好的生物相容性和生物活性，包括抗菌、消炎、抗氧化和血管生成特性。体内实验表明，这种水凝胶能明显改善小鼠糖尿病伤口的修复。有趣的是，这种水凝胶还具有独特的视觉 pH 值监测特性，可与智能手机无缝集成，实现图像可视化，并利用机器学习算法进一步实现可靠的伤口 pH 值评估，从而根据伤口 pH 值加强伤口管理。总之，这项研究提出了一种管理糖尿病伤口的综合再生策略。

{"title":"Smart hydrogel dressing for machine learning-enabled visual monitoring and promote diabetic wound healing","authors":"Duanyu Deng , Lihua Liang , Kaize Su , Han Gu , Xu Wang , Yan Wang , Xiangcun Shang , Wenhuan Huang , Henghui Chen , Xiaoxian Wu , Wing-Leung Wong , Dongli Li , Kun Zhang , Panpan Wu , Keke Wu","doi":"10.1016/j.nantod.2024.102559","DOIUrl":"10.1016/j.nantod.2024.102559","url":null,"abstract":"<div><div>Diabetic wounds are complex complications characterized by long-term chronic inflammation, vascular damage, and difficulties in healing. Monitoring wound pH can serve as an early warning system for infection risk and enhance wound management by tracking changes in wound pH. In this study, a machine learning-assisted analysis smart hydrogel as wound dressing was developed by utilizing a double cross-linked network hydrogel of gelatin methacrylate (GelMA) and chitosan methacrylate (CMCSMA) as the matrix, a compound of cobalt-gallic acid based metal-phenolic nanoparticles (GACo MPNs) as the active ingredients, and phenol red as the pH indicator. This smart hydrogel exhibits excellent injection performance, shape adaptability and mechanical strength. Besides, a series of <em>in vitro</em> experiments demonstrated the favorable biocompatibility and bioactivity of GelMA/CMCSMAP-GACo hydrogel, encompassing its antibacterial, anti-inflammatory, antioxidant, and angiogenic properties. <em>In vivo</em> experiments show that this hydrogel significantly improved the repair of diabetic wounds in mice. Interestingly, the hydrogel exhibited unique visual pH monitoring properties, which can be seamlessly integrated with a smartphone for image visualization and further enable reliable wound pH assessment using machine learning algorithms to enhance wound management based on wound pH. Overall, this study presented a comprehensive regenerative strategy for the management of diabetic wounds.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"60 ","pages":"Article 102559"},"PeriodicalIF":13.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural-based UV-shielding additives to protect photosensitive pesticides: Production of nanoparticles from the co-self-assembly of lignin and tannin 保护光敏农药的天然紫外线屏蔽添加剂：利用木质素和单宁的共自组装生产纳米颗粒

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-16 DOI: 10.1016/j.nantod.2024.102550

Ya Ma , Javier Remón , Lingjuan Luo , Wei Ding , Zhicheng Jiang , Bi Shi

This work explores the development of a renewable, carbon-neutral, light-colored UV-shielding film to protect photosensitive pesticides from solar radiation, as these chemicals are easily degraded under UV light, substantially reducing their efficiency and causing soil and water pollution. The abundant benzene rings in lignin and phenolic hydroxyls in tannin boosted the co-self-assembly of lignin and tannin into composite nanospheres by the simultaneous π-π stacking and H-bonding interactions between these two biopolymers. These lignin-tannin (LT) composite nanoparticles were used as natural UV-shielding additives to coat a poly-vinyl-alcohol (PVA) film, endowing the PVA-LT film with an excellent UV-shielding ability (>95 % efficiency) due to the strong π-π stacking and concentrated phenolic hydroxyls. Typical photosensitive pesticides covered with the PVA-LT film significantly increased their remaining rate by 1.5 times compared to those under the uncoated film. Besides, intensive intermolecular hydrogen bonds were generated between PVA and the abundant phenolic hydroxyl groups exposed on the hydrophilic shell of the LT coating, enhancing the mechanical properties and water vapor retention of the composite film. Our biodegradable composite film derived from natural plant extracts not only protected photosensitive pesticides from UV irradiation but also allowed the transmission of visible light to guarantee the photosynthesis process of crops.

由于光敏性农药在紫外线照射下很容易降解，大大降低了农药的使用效率，并造成土壤和水污染，因此这项研究探索开发一种可再生、碳中性、浅色的紫外线屏蔽膜，以保护光敏性农药免受太阳辐射。木质素中丰富的苯环和单宁中的酚羟基通过这两种生物聚合物之间同时存在的π-π堆积和H键相互作用，促进了木质素和单宁共同自组装成复合纳米球。这些木质素-单宁（LT）复合纳米粒子被用作天然紫外线屏蔽添加剂，涂覆在聚乙烯醇（PVA）薄膜上，由于强π-π堆积和浓缩的酚羟基，PVA-LT 薄膜具有极佳的紫外线屏蔽能力（效率高达 95%）。与未涂覆薄膜相比，涂覆 PVA-LT 薄膜的典型光敏农药的残留率显著提高了 1.5 倍。此外，PVA 与暴露在 LT 涂层亲水外壳上的大量酚羟基之间产生了密集的分子间氢键，从而增强了复合薄膜的机械性能和保水性。我们从天然植物提取物中提取的可生物降解复合膜不仅能保护光敏农药免受紫外线照射，还能透过可见光，保证农作物的光合作用过程。

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引用次数: 0

In situ atomic observation of transformation twinning in nanocrystals 原位原子观测纳米晶体中的转化孪晶

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-16 DOI: 10.1016/j.nantod.2024.102547

Qiubo Zhang , Hui Dong , Amy Ren , Yifan Nie , Haimei Zheng

The formation of twinning in nanocrystals impacts their physical and chemical properties. However, the pathways of transformation twinning triggered by an external stimulus is not well-understood. Here, we investigated the transformation twinning of face-centered cubic (FCC) metal nanocrystals under electron beam irradiation, utilizing transmission electron microscopy (TEM) with high spatiotemporal resolution. We found that a bi-crystal twin can form through swap motion as well as via a structural destruction-repair mechanism. The destruction-repair of crystal structure during twinning involves structure disruption, defects formation, and subsequent recrystallization. Regarding twinning through swap motion, nanocrystals maintain a relatively intact crystal structure, while crystal defects form and propagate during twin nucleation. For the transformation twinning evolving from a bi-crystal twin to fivefold twins (or the reverse processes in detwinning), twinning is accompanied by the decomposition of the twin boundaries, interface migration, and strain modulations. Our results provide new mechanistic understandings of transformation twinning in nanocrystals.

纳米晶体中孪晶的形成会影响其物理和化学特性。然而，人们对外界刺激引发转化孪晶的途径还不甚了解。在此，我们利用高时空分辨率的透射电子显微镜（TEM）研究了面心立方（FCC）金属纳米晶体在电子束辐照下的转变孪晶。我们发现，双晶孪生既可以通过交换运动形成，也可以通过结构破坏-修复机制形成。孪晶过程中晶体结构的破坏-修复包括结构破坏、缺陷形成和随后的再结晶。关于通过交换运动形成的孪晶，纳米晶体保持相对完整的晶体结构，而晶体缺陷则在孪晶成核过程中形成和扩散。对于从双晶孪晶演变为五倍孪晶的转变孪晶（或脱晶中的相反过程），孪晶伴随着孪晶边界的分解、界面迁移和应变调制。我们的研究结果为理解纳米晶体中的转变孪晶提供了新的机理。

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引用次数: 0

Energy-based surgery generated carbonized particles promote the development of ovarian cancer 基于能量的手术产生的碳化粒子会促进卵巢癌的发展

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-15 DOI: 10.1016/j.nantod.2024.102555

Yan Chen , Jian Liu , Binhan Wang , Xiao Liang , Yanfei Yang , Xia Zhao , Min Luo , Xiawei Wei

Cancer patients face a high risk of tumor recurrence and metastasis after surgery. Surgical stress has been reported to be an important trigger for cancer recurrence and metastasis. Energy-based surgical devices have become the most commonly used surgical tool in recent years. However, there is a lack of studies investigating whether using energy-based surgical devices promotes the development of residual tumors. This study aimed to examine the impact of energy-based surgery on tumor growth in comparison to conventional surgery. Results indicated that energy-based surgery is more likely to promote tumor growth than conventional surgery. Further investigation revealed that the carbonized particles produced by energy-based surgical devices during tissue combustion are robust inducers, strongly inducing the polarization of M2-like macrophages in vivo and in vitro. Additionally, carbonized particles induced an immunosuppressive tumor microenvironment in vivo, promoting tumor growth similarly to energy-based surgery. These findings suggested that the production of carbonized particles during energy-based surgery contributed to the development of residual tumor cells. Therefore, it is advisable to implement measures to either eliminate or prevent the production of carbonized particles during energy-based surgery procedures.

癌症患者术后面临肿瘤复发和转移的高风险。据报道，手术应激是癌症复发和转移的重要诱因。近年来，基于能量的手术设备已成为最常用的手术工具。然而，目前还缺乏对使用能量手术设备是否会促进残留肿瘤发展的研究。本研究旨在探讨与传统手术相比，能量手术对肿瘤生长的影响。结果表明，与传统手术相比，能量手术更有可能促进肿瘤生长。进一步研究发现，能量手术设备在组织燃烧过程中产生的碳化颗粒是一种强诱导剂，能在体内和体外强烈诱导 M2 样巨噬细胞极化。此外，碳化粒子还能在体内诱导免疫抑制性肿瘤微环境，促进肿瘤生长，这一点与能量手术类似。这些研究结果表明，能量手术过程中产生的碳化粒子导致了残留肿瘤细胞的发展。因此，最好采取措施消除或防止能量手术过程中产生碳化粒子。

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引用次数: 0

Adipose tissue targeted sequential delivery system regulating glycolipid metabolism for systemic obesity and its comorbidities 调节糖脂代谢的脂肪组织定向序贯给药系统，用于治疗全身性肥胖症及其合并症

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-14 DOI: 10.1016/j.nantod.2024.102553

Yingxian Chen , Xinmiao Lan , Junhua Han , Xin Xiang , Qingmeng Li , Xiaolong Xu , Tingting Wang , Siying Huang , Jianzhong Shen , Xiaowei Ma

Obesity has emerged as a chronic, relapsing, progressive disease globally. Available methods including pharmacotherapy, surgery, and limotherapy, may lead to toxicities and gastrointestinal disturbances due to their lack of adipose tissue targetability. Increasing energy expenditure and reducing gluconeogenesis through browning of white adipose tissue (WAT) is a therapeutic target for obesity and its comorbidities. Here, we constructed a biomimetic discoidal recombinant high-density lipoprotein (rHDL) with high specificity for scavenger receptor class B type I (SR-BI). rHDL enables targeted delivery of combination drugs (RM) containing rosiglitazone (Rosi) and metformin (Met) to WAT, liver, and intestine, that express elevated levels of SR-BI, resulting in promoted browning of WAT, enhanced mitochondrial biogenesis, and adipocyte thermogenesis increase. For oral delivery, rHDL@RM was loaded in pH-senstive sodium alginate chitosan complex microspheres (MS), enabling stepwise release in the gastrointestinal tract, with mucosal penetration capability that facilitating longlasting lipid-lowering effect. Diet-induced obese (DIO) mice treated with rHDL@RM/MS showed 44.6 % reduction in body weight, with decreased serum glucose and lipid levels. Obesity comorbidities, including NAFLD, gut microbiome disorders, systemic lipid metabolism abnormalities, and chronic inflammation, were all effectively suppressed. Our designed rHDL@RM/MS oral-nanoplatform represents a valuable therapeutic strategy for painless treatment of systemic obesity and related comorbidities.

肥胖症已成为一种全球性的慢性、复发性、进展性疾病。现有的方法包括药物疗法、手术疗法和限制疗法，由于缺乏对脂肪组织的靶向性，可能会导致毒性和胃肠道功能紊乱。通过白脂肪组织（WAT）褐变来增加能量消耗和减少葡萄糖生成是肥胖症及其合并症的治疗目标。在这里，我们构建了一种生物仿生盘状重组高密度脂蛋白（rHDL），它对清道夫受体 B 类 I 型（SR-BI）具有高度特异性。rHDL 可以将含有罗格列酮（Rosi）和二甲双胍（Met）的联合药物（RM）靶向递送到 SR-BI 表达水平升高的白脂肪组织、肝脏和肠道，从而促进白脂肪组织褐变、线粒体生物生成增强和脂肪细胞产热增加。在口服给药方面，将 rHDL@RM 添加到具有 pH 值选择性的海藻酸钠壳聚糖复合微球（MS）中，使其能够在胃肠道中逐步释放，并具有粘膜渗透能力，从而促进持久的降脂效果。经 rHDL@RM/MS 治疗的饮食诱发肥胖（DIO）小鼠体重下降了 44.6%，血清葡萄糖和血脂水平也有所下降。肥胖合并症，包括非酒精性脂肪肝、肠道微生物组紊乱、全身脂质代谢异常和慢性炎症均得到有效抑制。我们设计的rHDL@RM/MS口服纳米平台是无痛治疗全身性肥胖及相关并发症的重要治疗策略。

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引用次数: 0

CD33 targeted EzH1 regulated nanotherapy epigenetically inhibits fusion oncoprotein (AML1-ETO) rearranged acute myeloid leukemia in both in vitro and in vivo Patient Derived Xenograft models 在体外和体内患者衍生异种移植模型中，CD33 靶向 EzH1 调控纳米疗法从表观遗传学角度抑制融合癌蛋白（AML1-ETO）重排的急性髓性白血病

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-14 DOI: 10.1016/j.nantod.2024.102542

Avinash Chandra Kushwaha , Boddu Mrunalini , Devangi Ghosh , Pankaj Malhotra , Surajit Karmakar , Subhasree Roy Choudhury

Acute myeloid leukemia (AML) is one of the most heterogeneous myeloid malignancies wherein the genetic and epigenetic markers contribute to AML pathogenesis. Genetic regulators such as fusion oncogene, AML1-ETO, controls AML pathogenesis and contribute to ∼20 % AML cases. The epigenetic factors such as histone methyltransferase, EzH1, is highly overexpressed in AML and regulate AML proliferation. The EzH1 inhibition overturns disease pathology but available therapeutics exhibit off-target toxicity and frequent relapses which lack AML targeting ability. Here, we have prepared CD33-targeted S30 aptamer-functionalized human serum albumin nanoparticles for EzH1 siRNA delivery for the first time as anti-AML therapeutics in vitro, in vivo nude mice and patient-derived xenografts models. The S30 aptamer functionalization enhanced the transfection efficiency and cytotoxicity through apoptosis and increased the reduction of c-Kit⁺ leukemia cells along with upregulation of myeloid differentiation markers, CD11b and Gr-1, in nude mice AML xenografts. The nanoparticles exhibited the similar efficacy with improved survival outcome in patient-derived xenografts. Furthermore, we for the first time showed that transcription factor, C-Myb, directly regulates EzH1 through promoter binding which regulates the functional characteristics of in vivo AML. The present nanotherapy abrogates C-Myb–EzH1 crosstalk mediated AML pathogenesis and holds future translation potential as novel anti-AML therapeutics.

急性髓性白血病（AML）是异质性最强的髓系恶性肿瘤之一，遗传和表观遗传标记物对AML的发病机制起着重要作用。基因调控因子（如融合癌基因 AML1-ETO）控制着急性髓细胞白血病的发病机制，并导致 20% 的急性髓细胞白血病病例。组蛋白甲基转移酶 EzH1 等表观遗传因子在急性髓细胞性白血病中高度过表达，并调控急性髓细胞性白血病的增殖。抑制 EzH1 可改善疾病的病理变化，但现有的治疗药物具有脱靶毒性，且经常复发，缺乏针对急性髓细胞性白血病的靶向能力。在此，我们首次制备了 CD33 靶向 S30 通感素功能化人血清白蛋白纳米颗粒，用于在体外、体内裸鼠和患者衍生异种移植模型中递送 EzH1 siRNA 作为抗 AML 治疗药物。在急性髓细胞性白血病裸鼠异种移植中，S30 aptamer 功能化提高了转染效率，通过细胞凋亡增强了细胞毒性，减少了 c-Kit+ 白血病细胞，同时上调了髓系分化标志物 CD11b 和 Gr-1。纳米颗粒在患者来源的异种移植中也表现出类似的疗效，并改善了存活率。此外，我们首次发现转录因子 C-Myb 通过启动子结合直接调控 EzH1，从而调控体内急性髓细胞性白血病的功能特征。本纳米疗法可抑制C-Myb-EzH1串联介导的急性髓细胞性白血病发病机制，未来有望转化为新型抗急性髓细胞性白血病疗法。

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