Nano Today最新文献_第10页

DNA nanohydrogel and Pb2 + -specific recognition enable one-pot electrochemical exosome aptasensor for staging of breast cancer DNA纳米水凝胶和Pb2 +特异性识别使一罐电化学外泌体适体传感器能够用于乳腺癌分期

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-30 DOI: 10.1016/j.nantod.2025.102854

Xiangyue Meng , Xin Zhao , Weijing Liu , Yue Wang , Jie Chen , Kai Chang , Piaopiao Chen

In this study, a one-pot electrochemical aptasensor was developed for the rapid and sensitive detection of tumor-derived exosomes. This strategy used a target-responsive DNA nanohydrogel that integrated an aptamer for specific recognition, with Pb²⁺ serving as the signal output element. The key innovation of this homogeneous method lied in its ability to distinguish between free Pb²⁺ and the G-quadruplex-Pb²⁺ complex through electrochemical analysis. Epithelial cell adhesion molecule (EpCAM) was selected as the target for breast cancer-derived exosomes. The binding of the aptamer to the target triggered the disintegration of the DNA nanohydrogel, exposing abundant G-quadruplexes that selectively bound to Pb²⁺, thereby amplifying the electrochemical signal and enabling sensitive detection. Additionally, the analysis system was completed within 45 min, with a limit of detection (LOD) of 300 particles/mL. Meanwhile, the application of this strategy to clinical samples enabled accurate differentiation between breast cancer patients (n = 40) and healthy controls (n = 12), achieving a specificity, sensitivity, and accuracy of 91.7 % (11/12), 95 % (38/40), and 96.2 %, respectively. Furthermore, this approach demonstrated strong capability in differentiating between early- and advanced-stage cancer with 86.1 % accuracy. These findings were in strong agreement with imaging and pathological results. Overall, this exosome-based liquid biopsy method demonstrates significant potential for enhancing breast cancer diagnosis and staging, providing valuable support for personalized treatment decisions.

在本研究中，开发了一种用于快速灵敏检测肿瘤来源外泌体的一罐电化学配体传感器。该策略使用了一种靶向性DNA纳米水凝胶，该凝胶整合了用于特定识别的适体，Pb2+作为信号输出元件。这种均相方法的关键创新之处在于它能够通过电化学分析区分游离Pb2+和g -四复体Pb2+配合物。上皮细胞粘附分子（Epithelial cell adhesion molecule, EpCAM）被选为乳腺癌源性外泌体的靶标。适配体与靶标的结合触发了DNA纳米水凝胶的解体，暴露出大量选择性结合Pb2+的g -四plex，从而放大了电化学信号并实现了敏感检测。此外，分析系统在45 min内完成，检出限（LOD）为300颗粒/mL。同时，将该策略应用于临床样本，可以准确区分乳腺癌患者（n = 40）和健康对照（n = 12），特异性、敏感性和准确性分别为91.7 %（11/12）、95 %（38/40）和96.2 %。此外，该方法在区分早期和晚期癌症方面表现出很强的能力，准确率为86.1% %。这些发现与影像学和病理结果非常一致。总之，这种基于外泌体的液体活检方法显示了增强乳腺癌诊断和分期的巨大潜力，为个性化治疗决策提供了有价值的支持。

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引用次数: 0

Self-assembled copper-phenolic nanoparticles for antimicrobial therapy by triggering Fenton reaction and cuproptosis-like bacterial death 自组装铜酚纳米颗粒通过触发芬顿反应和铜中毒样细菌死亡进行抗菌治疗

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-14 DOI: 10.1016/j.nantod.2025.102850

Yongcheng Chen , Fang Liu , Haojie Chen , Yue Huang , Yutong Li , Qiao Jin , Jian Ji

The increasing prevalence of antibiotic-resistant bacteria poses a significant threat to global health. This study introduces poly(ethylene glycol)-copper-tannic acid nanoparticles (PCT NPs) as a novel therapeutic strategy for treating bacterial infections. PCT NPs, synthesized via self-assembly of Cu²⁺, tannic acid, and poly(ethylene glycol), exhibit pH-responsive release of Cu²⁺, which generates reactive oxygen species (ROS) and depletes glutathione (GSH) in bacterial cells, leading to cuproptosis-like bacterial death. PCT NPs also demonstrate strong adhesion to bacterial surfaces, enhancing their ability to deliver Cu²⁺ directly to bacterial cells. In vitro experiments demonstrate strong bactericidal activity against MRSA and P. aeruginosa. In vivo studies in murine models of skin and lung infections confirm the efficacy of PCT NPs in reducing bacterial load and promoting wound healing. This work highlights PCT NPs as a promising non-antibiotic alternative for combating deep-seated bacterial infections.

耐抗生素细菌的日益流行对全球健康构成重大威胁。本研究介绍了聚乙二醇铜单宁酸纳米颗粒（PCT NPs）作为一种治疗细菌感染的新策略。PCT NPs是由Cu 2 +、单宁酸和聚乙二醇自组装合成的，它表现出Cu 2 +的ph响应性释放，在细菌细胞中产生活性氧（ROS）并消耗谷胱甘肽（GSH），导致铜中毒样细菌死亡。PCT NPs还表现出对细菌表面的强粘附性，增强了它们直接将Cu 2 +传递到细菌细胞的能力。体外实验显示对MRSA和铜绿假单胞菌有较强的杀菌活性。小鼠皮肤和肺部感染模型的体内研究证实了PCT NPs在减少细菌负荷和促进伤口愈合方面的功效。这项工作强调了PCT NPs作为对抗深层细菌感染的有前途的非抗生素替代品。

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引用次数: 0

An integrated therapeutic strategy to enhance cuproptosis through adaptive activation and microenvironment remodeling of prodrug complexes 通过前药复合物的自适应激活和微环境重塑来促进铜形体形成的综合治疗策略

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-14 DOI: 10.1016/j.nantod.2025.102853

WeiYe Ren , WeiYi Cheng , Li He , Xiujuan Hong , JingQuan Chen , Yajun Wu , Dandan Bao , Yinghui Wei , Ji-Gang Piao , Zhibing Wu

Colorectal cancer (CRC) progression is critically driven by its hydrogen sulfide (H₂S)-rich tumor microenvironment, which paradoxically confers chemoresistance by stabilizing redox homeostasis while promoting immune evasion. To transform this vulnerability into a therapeutic opportunity, we developed an H₂S-responsive dual prodrug system (As-Cu/DSF@TPP⁺) that leverages endogenous H₂S overexpression as a biochemical trigger. This system operates through a cascading mechanism: (1) Tumor-specific H₂S activation reduces nontoxic As⁵⁺ to cytotoxic As³ ⁺, disrupting mitochondrial copper homeostasis and initiating cuproptosis via lipoylated protein aggregation; (2) Released Cu²⁺ reacts with H₂S to generate photothermally active copper sulfide, enabling localized hyperthermia therapy; (3) Disulfiram-derived CuET establishes a self-amplifying loop, simultaneously depleting H₂S through CBS enzyme inhibition and amplifying copper accumulation. The coordinated action achieves dual therapeutic breakthroughs: cascading cuproptosis through mitochondrial copper overload and Fe-S cluster destabilization, coupled with immunogenic cell death-driven TME remodeling that enhances dendritic cell maturation and cytotoxic T-cell infiltration. By integrating H₂S scavenging, cuproptosis induction, and photothermal-immunotherapy, this strategy establishes a "gas signaling molecule-programmed nanotherapy" paradigm. It not only overcomes CRC-specific resistance mechanisms but also provides a universal framework for targeting H₂S-high malignancies, demonstrating how endogenous tumor defense systems can be repurposed into precision therapeutic weapons.

结直肠癌（CRC）的进展是由其富含硫化氢（H₂S）的肿瘤微环境驱动的，该微环境通过稳定氧化还原稳态而促进免疫逃逸，从而矛盾地赋予化疗耐药。为了将这种脆弱性转化为治疗机会，我们开发了一种H₂S响应双前药系统（as - cu /DSF@TPP⁺），该系统利用内源性H₂S过表达作为生化触发器。该系统通过级联机制运行：(1)肿瘤特异性H₂S激活将无毒的As 5 +还原为细胞毒性的As³ +，破坏线粒体铜稳态，并通过脂化蛋白聚集启动铜还原；(2)释放的Cu 2 +与H₂S反应生成光热活性的硫化铜，实现局部热疗；(3)双硫仑衍生CuET建立了一个自扩增回路，同时通过CBS酶抑制消耗H₂S，放大铜积累。协同作用实现了双重治疗突破：通过线粒体铜过载和Fe-S簇不稳定的级联铜退化，加上免疫原性细胞死亡驱动的TME重塑，增强树突状细胞成熟和细胞毒性t细胞浸润。通过整合h2s清除、铜还原诱导和光热免疫疗法，该策略建立了一种“气体信号分子编程纳米疗法”范式。它不仅克服了crc特异性耐药机制，而且为靶向高H₂s恶性肿瘤提供了一个通用框架，展示了内源性肿瘤防御系统如何被重新利用为精确治疗武器。

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引用次数: 0

Inflammation-responsive monocyte-biomimetic nanobubbles realizing microvascular recanalization and xenon neuroprotection in ischemic stroke 炎症反应性单核细胞仿生纳米泡实现缺血性脑卒中微血管再通和氙神经保护

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-12 DOI: 10.1016/j.nantod.2025.102851

Moran Wang , Wenjun Zhao , Qiang Zhang , Mei Li , Xiang Sun , Kailin Wang , Bin Huang , Mingfei Pan , Juan Jin , Ning Gu

Ischemic stroke (IS) is an acute and severed disease with vascular inflammation prior to thrombus events. Considering the current treatment strategies focus on the thrombus-target effect, reaching the early intervention and extending therapeutic time windows remains a key challenge. Herein, inspired by the monocyte infiltration mechanism to the early stroke lesion, nanobubbles encapsulating xenon with monocyte membrane shell (Xe-MNBs) are designed for emergency theranostics of IS. Xe-MNBs quickly target to the inflammatory damaged vessels and competitively inhibit the inflammatory progression via abundant membrane cytokine receptors. Afterwards, Xe-MNBs serve as a platform to recanalize microvasculature and locally deliver neuroprotective Xe in the stroke lesion, synergistically extending the “door-to-needle” streamline. In photothrombotic ischemic stroke mice, the aggregation of Xe-MNBs in stroke brains reaches approximately 8.2 times higher than normal brains within 0.5 h of stroke induction. In vivo results confirmed that blood flow perfusion, neuroprotection and inflammation inhibition can significantly improve the neurological recovery of stroke mice, also investigated by gene transcriptome analysis. This work provides a novel monocyte-biomimetic nanosystem for inflammation-responsive drug delivery and gives a proof of concept for priority management of IS with Xe-MNBs.

缺血性脑卒中（IS）是一种急性切断性疾病，在血栓事件发生前伴有血管炎症。考虑到目前的治疗策略侧重于血栓靶效应，实现早期干预和延长治疗时间窗仍然是一个关键的挑战。在此，受单核细胞浸润早期脑卒中病变机制的启发，设计了用单核细胞膜壳包裹氙的纳米气泡（Xe-MNBs）用于IS的急诊治疗。Xe-MNBs快速靶向炎症损伤血管，并通过丰富的膜细胞因子受体竞争性地抑制炎症进展。然后，Xe- mnbs作为一个平台，重新通微血管，并在脑卒中病变中局部传递神经保护性的Xe，协同延长“门到针”的流线。在光血栓性缺血性脑卒中小鼠中，在脑卒中诱导0.5 h内，脑卒中脑组织中Xe-MNBs的聚集量比正常脑组织高约8.2倍。体内实验结果证实血流灌注、神经保护和炎症抑制能显著改善脑卒中小鼠的神经恢复，并通过基因转录组分析进行了研究。这项工作为炎症反应性药物递送提供了一种新的单核细胞仿生纳米系统，并为使用Xe-MNBs优先管理IS的概念提供了证明。

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引用次数: 0

Harnessing hydrogen spillover: Biomimetic dual-site platinum-gold catalyst mimicking NAD+ -reducing hydrogenase 利用氢溢出：模拟NAD+还原氢化酶的仿生双位点铂金催化剂

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-11 DOI: 10.1016/j.nantod.2025.102852

Panpan Zhao , Rui Li , Jianguo Zhao , Yuehan Zhang , Zhixuan Yu , He Zhang , Shaojun Dong

The hydrogen spillover phenomenon in heterogeneous catalysis shares similarities with the proton-coupled electron transfer (PCET) mechanism observed in natural enzymes. Drawing inspiration from these mechanisms, biomimetic dual-site platinum-gold (PtAu) catalyst was theoretical designed as a model to mimic the function of soluble NAD⁺-reducing hydrogenases (SH). This model catalyst facilitates efficient hydrogen oxidation and NAD⁺ reduction, offering potential applications in both bioelectrocatalysis and biosynthetic systems. In the design, Pt and Au simulated the NiFe and FMN active sites of SH, respectively, with hydrogen spillover serving as an alternative to the PCET mechanism. Experimental results and theoretical calculations revealed the individual contribution and synergistic interactions between Pt and Au, where Pt sites dissociated H₂ to produce active hydrogen which spontaneously spilled to neighboring Au sites for adsorbed NAD⁺ hydrogenation. In biocatalysis, PtAu catalyst exhibited superior NAD⁺ conversion efficiency and selectivity toward 1,4-NADH compared to previously reported Pt-based catalysts. In electrocatalysis, a H₂/O₂ enzymatic biofuel cell was constructed, achieving a maximum power output exceeding 2.0 mW cm⁻² while maintaining excellent operational stability. This mechanism-inspired strategy provided valuable insights into the understanding and design of catalysts, thereby offering greater potential for applications in replacing natural enzymatic catalysis.

多相催化中的氢溢出现象与天然酶中的质子耦合电子转移（PCET）机制有相似之处。从这些机制中获得灵感，仿生双位点铂金（PtAu）催化剂被设计为模拟可溶性NAD+还原氢化酶（SH）功能的模型。该模型催化剂促进了高效的氢氧化和NAD+还原，在生物电催化和生物合成系统中都有潜在的应用。在设计中，Pt和Au分别模拟了SH的NiFe和FMN活性位点，氢气溢出作为PCET机制的替代机制。实验结果和理论计算揭示了Pt和Au之间的个体贡献和协同作用，其中Pt位点解离H2产生活性氢，并自发地溢出到邻近的Au位点吸附NAD+氢化。在生物催化方面，与先前报道的基于pt的催化剂相比，PtAu催化剂对1,4- nadh的转化效率和选择性更高。在电催化方面，构建了H2/O2酶生物燃料电池，最大输出功率超过2.0 mW cm−2，同时保持了良好的运行稳定性。这种机制启发的策略为催化剂的理解和设计提供了有价值的见解，从而为取代天然酶催化的应用提供了更大的潜力。

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引用次数: 0

Glycyrrhetinic acid-albumin nanoparticles with bimodal pharmacological activities for time-dependent restoration of acute liver injury 具有双峰药理活性的甘草次酸-白蛋白纳米颗粒对急性肝损伤时间依赖性恢复的作用

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-09 DOI: 10.1016/j.nantod.2025.102849

Baoyuan Zhang , Yixin Sun , Shengbo Yuan , Shufang Zheng , Yongke Zhang , Zuo Zhang , Dongyu Zhang , Jiayu Guo , Xianbao Shi , Jin Sun , Zhonggui He , Bingjun Sun

Acute liver injury (ALI) represents a critical initiating event for deterioration into severe hepatitis or fatal acute liver failure. Glycyrrhizin acid has shown clinical effectiveness in managing liver injury and hepatitis, but it requires metabolic conversion to glycyrrhetinic acid (GA) to be effective. However, the application of GA is impeded by poor solubility and rapid clearance. Given the ultra-high albumin affinity of GA, three GA-human serum albumin nanoparticles (GA@HSA NPs) with optimized mass ratios (1:0.5, 1:1, and 1:2) were reported. Molecular dynamics simulations revealed that GA predominantly occupied structural domain IIA within Sudlow site I of HSA. Upon administration, the hepatic retention of GA@HSA NPs was significantly increased, especially for 1:2 GA@HSA NPs. Notably, GA@HSA NPs exhibited bimodal pharmacological activities, including time-dependent prophylactic and therapeutic effects on ALI, which were achieved by decreasing intracellular nitric oxide (NO), reactive oxygen species (ROS), and restoring pro-inflammatory macrophages to normal macrophages. In preventive mode, 1:2 GA@HSA NPs even restored liver function indicators involved in ALI to normal levels while ensuring safety, displaying potent therapeutic benefits. These findings established a paradigm for liver targeting therapy, offering mechanistic insights and translational potential for ALI management.

急性肝损伤（ALI）是恶化为严重肝炎或致死性急性肝衰竭的关键起始事件。甘草酸已显示出治疗肝损伤和肝炎的临床有效性，但它需要代谢转化为甘草酸（GA）才能有效。然而，GA的应用受到溶解度差和快速清除的阻碍。考虑到GA对白蛋白的超高亲和力，报道了三种GA-人血清白蛋白纳米颗粒（GA@HSA NPs），其优化质量比为1:0.5、1:1和1:2。分子动力学模拟表明，GA主要占据HSA Sudlow位点I的结构域IIA。给药后，GA@HSA NPs的肝潴留显著增加，尤其是1:2 GA@HSA NPs。值得注意的是，GA@HSA NPs表现出双峰药理活性，包括对ALI的时间依赖性预防和治疗作用，这是通过降低细胞内一氧化氮（NO）、活性氧（ROS）和将促炎巨噬细胞恢复到正常巨噬细胞来实现的。在预防模式下，1:2 GA@HSA NPs甚至可以在确保安全性的情况下将ALI相关的肝功能指标恢复到正常水平，显示出强有力的治疗效果。这些发现为肝脏靶向治疗建立了一个范例，为ALI管理提供了机制见解和转化潜力。

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引用次数: 0

Anti-SV2C single domain nanobodies for molecular imaging in androgen receptor positive prostate cancer 抗sv2c单域纳米体在雄激素受体阳性前列腺癌中的分子成像研究

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-09 DOI: 10.1016/j.nantod.2025.102846

Ziye Liu , Jiahao Zhou , Jiangyan Liu , Chengmu Zhao , Zhencun Cui , Qinqin Wang , Wantong Ma , Xinyao Ma , Futian Tang , Xin Wang , Yumin Li , Dejuan Zhi , Dongsheng Wang

Prostate cancer (PCa) is one of the most prevalent malignant tumors in men worldwide. Because of its highly heterogeneous, the accurate diagnosis of PCa is critical to the selection of appropriate treatment strategy. In present work, high affinity nanobody 1-H9, a variable domain of heavy-chain antibody (VHH) against SV2C was developed by phage display library screening. Showing by 1-H9, SV2C was selectively expressed in androgen receptor (AR) positive prostate tumor cell LNCaP, but not AR negative tumor cell PC3. In LNCaP cells, SV2C and AR were first observed to co-localize on the mitochondrial membrane. Subsequent pull-down assays confirmed that AR, when used as bait, directly interacted with SV2C (the prey), suggesting a physical association between the two proteins. Furthermore, on clinical PCa biopsy specimens, SV2C and AR staining were highly correlated in immunohistochemistry assay. Confirmed in pre-clinical animal models, both fluorescence imaging and ⁶⁸Ga PET/CT imaging showed SV2C was significant enriched in LNCaP tumor. Our results suggest that in contrast to SV2A being used for neuronal endocrine PCa diagnosis, SV2C is a novel biomarker for accurate diagnosis of AR positive PCa. The nanobody 1-H9 developed against SV2C-LD4 domain is promising to be used as an effective molecular imaging probe for AR positive PCa.

前列腺癌是世界范围内最常见的男性恶性肿瘤之一。由于前列腺癌具有高度的异质性，准确的诊断对于选择合适的治疗策略至关重要。本研究通过噬菌体展示文库筛选，构建了高亲和力的抗SV2C重链抗体可变结构域1-H9纳米体。1-H9显示，SV2C在雄激素受体（AR）阳性的前列腺肿瘤细胞LNCaP中选择性表达，而在AR阴性的前列腺肿瘤细胞PC3中不表达。在LNCaP细胞中，SV2C和AR首次被观察到在线粒体膜上共定位。随后的下拉试验证实，当AR被用作诱饵时，它直接与SV2C（猎物）相互作用，这表明两种蛋白质之间存在物理关联。此外，在临床前列腺癌活检标本中，免疫组化检测显示SV2C和AR染色高度相关。临床前动物模型证实，荧光成像和68Ga PET/CT成像均显示LNCaP肿瘤中SV2C显著富集。我们的研究结果表明，与SV2A用于神经内分泌型PCa诊断不同，SV2C是一种准确诊断AR阳性PCa的新型生物标志物。靶向SV2C-LD4结构域的纳米体1-H9有望作为AR阳性PCa的有效分子成像探针。

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引用次数: 0

Self-pumping, pH-responsive Janus fibrous dressing for enhanced immunomodulation and accelerated diabetic wound healing 自泵，ph响应Janus纤维敷料增强免疫调节和加速糖尿病伤口愈合

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-07-04 DOI: 10.1016/j.nantod.2025.102847

Zhou Sha , Jing Li , Yuheng Song , Hongchuang Li , Hongmei Liu , Jiahui Fan , Xueyong Li , Xiang Fei , Meifang Zhu

Diabetic wounds, characterized by excessive exudate accumulation and dysregulated inflammation, pose a global healthcare challenge due to their persistent non-healing nature. Traditional therapies often fail to simultaneously address three critical healing requirements: precise exudate management, coordinated inflammation-immune modulation, and pro-regenerative microenvironment establishment. Here, we present an innovative self-pumping Janus fibrous dressing integrating curcumin-loaded polycaprolactone nanofibers with cotton gauze. Its gradient architecture enables spontaneous exudate drainage and dynamic microenvironment modulation, establishing an optimal milieu for accelerated wound healing. Comprehensive in vitro investigations validate the dressing’s multifunctionality, including sensitive colorimetric pH response, antibacterial properties (>99 % inhibition against S. aureus), and antioxidant capabilities (>90 % DPPH radical scavenging). In vivo studies in a diabetic mice model demonstrate the dressing’s superior wound healing efficacy, with ∼47 % reduction in wound edge maceration, mitigated inflammatory responses, and enhanced angiogenesis compared to commercial cotton dressings. This novel approach provides a promising foundation for the development of advanced wound dressings tailored for the management and healing of chronic wounds.

糖尿病性伤口，其特征是大量渗出物积累和炎症失调，由于其持续不愈合的性质，构成了全球医疗保健的挑战。传统疗法往往不能同时满足三个关键的愈合要求：精确的渗出液管理、协调的炎症免疫调节和促进再生的微环境建立。在这里，我们提出了一种创新的自泵Janus纤维敷料，将姜黄素负载的聚己内酯纳米纤维与棉纱结合在一起。它的梯度结构使自发渗出液引流和动态微环境调节，为加速伤口愈合建立了最佳环境。全面的体外研究证实了该药膏的多功能性，包括敏感的比色pH反应、抗菌性能（对金黄色葡萄球菌的抑制率>； 99% %）和抗氧化能力（>； 90% %的DPPH自由基清除能力）。在糖尿病小鼠模型中的体内研究表明，与商业棉敷料相比，该敷料具有优越的伤口愈合功效，伤口边缘浸渍减少~ 47% %，减轻炎症反应，促进血管生成。这种新颖的方法为开发适合慢性伤口管理和愈合的高级伤口敷料提供了有希望的基础。

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引用次数: 0

Gold nanoparticle-loaded multifunctional Ti3C2Tx MXene nanosheets fabricated by in situ reduction to effectively enhance their catalase-like activity for tumor therapy 利用原位还原法制备了负载金纳米粒子的多功能Ti3C2Tx MXene纳米片，有效增强了其过氧化氢酶样活性，用于肿瘤治疗

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-06-28 DOI: 10.1016/j.nantod.2025.102848

Yuhao Guo , Jinyu Wang , Xiaomei Wu , Qianqian Qiao , Tao Liao , Linwei Li , Ziqiang Xu , Di-Wei Zheng , Ying Kuang , Wenqian Yu , Cao Li

Designing novel, high-performance nanozymes is essential for developing biocatalytic therapeutics, a promising therapeutic approach. In this work, gold nanoparticles (Au NPs)-loaded Ti₃C₂T_x MXene nanosheets (Ti₃C₂T_x-Au) are prepared by in situ reduction and then modified with polyethylene glycol (PEG) to obtain a multifunctional anticancer cascade enzyme system, Ti₃C₂T_x-Au-PEG (TANP). The photothermal properties of Ti₃C₂T_x in the near-infrared (NIR) region allow for its use in photothermal therapy (PTT). The complexation of Au NPs with Ti₃C₂T_x significantly enhances the catalase-like (CAT) activity of TANP, while incubating the glucose oxidase (GOx)- and peroxidase (POD)-like properties of TANP. The strong CAT-like property of TANP allows it to decompose the H₂O₂ overexpressed in cancer cells into O₂, which alleviates hypoxia. It can also be used for glucose catabolism in cancer cells, i.e., GOx-like induced starvation therapy. H₂O₂, one of the glucose degradation products, can be supplied to TANP to generate O₂ and POD-like induced reactive oxygen species (ROS) generation to kill cancer cells. Density functional theory (DFT) calculations provide possible reasons for the enhanced CAT-like activity of Ti₃C₂T_x-Au. Photothermal can enhance enzyme activity and can also be combined with biocatalytic therapy to achieve good therapeutic effects.

设计新颖、高性能的纳米酶是开发生物催化疗法的关键，是一种有前途的治疗方法。本文采用原位还原法制备了负载Ti3C2Tx MXene纳米片（Ti3C2Tx-Au）的金纳米颗粒（Au NPs），并用聚乙二醇（PEG）修饰，得到了多功能抗癌级联酶体系Ti3C2Tx-Au-PEG （TANP）。Ti3C2Tx在近红外（NIR）区域的光热特性允许其用于光热治疗（PTT）。Au NPs与Ti3C2Tx络合显著增强TANP的过氧化氢酶样（CAT）活性，同时培养TANP的葡萄糖氧化酶（GOx）和过氧化物酶（POD）样性质。TANP具有很强的cat样特性，可以将癌细胞中过表达的H2O2分解为O2，缓解缺氧。它也可用于癌细胞的葡萄糖分解代谢，即gox样诱导饥饿治疗。作为葡萄糖降解产物之一的H2O2可以供给TANP生成O2，并产生类似pod的诱导活性氧（reactive oxygen species， ROS）杀死癌细胞。密度泛函理论（DFT）计算为Ti3C2Tx-Au的cat样活性增强提供了可能的原因。光热可以增强酶的活性，也可以与生物催化疗法相结合，达到良好的治疗效果。

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引用次数: 0

Innovative wrinkle fabrication on polymer surfaces: Applications in optics and anti-counterfeiting 聚合物表面的创新皱纹制造：在光学和防伪中的应用

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-06-27 DOI: 10.1016/j.nantod.2025.102843

Dengchong Feng , Xixi Su , Rui Chen , Haoran Chen , Yuzhao Yang , Shaolin Lu , Zhongke Yuan , Xudong Chen

In the realm of advanced materials, wrinkling surface materials stand out for their innovative use of buckling instability to create adjustable micro-nano structures. This technique offers significant advantages over traditional methods, including simplified processes, lower reliance on high-precision equipment, and excellent scalability. In recent years, with a deeper understanding of the mechanisms behind wrinkle formation, the regular and tunable periodic morphology has enabled wrinkling surface materials to shine in the field of optics. Subsequently, the development of wrinkle materials with various responsive properties has opened up new possibilities for cutting-edge applications in anti-counterfeiting and robust smart devices. This review summarizes the principles and methods for generating wrinkles, detailing the mechanisms and main approaches for controlling the surface morphology of wrinkling materials. Finally, we review the applications of wrinkling materials in optics and optical encryption, highlighting their emerging utility and potential in these fields.

在先进材料领域，起皱表面材料因其创新地使用屈曲不稳定性来创建可调节的微纳米结构而脱颖而出。与传统方法相比，该技术具有显著的优势，包括简化流程、降低对高精度设备的依赖以及出色的可扩展性。近年来，随着人们对起皱机理的深入了解，规律可调的周期形态使起皱表面材料在光学领域大出风头。随后，具有各种响应特性的抗皱材料的开发为防伪和强大的智能设备的尖端应用开辟了新的可能性。本文综述了皱褶产生的原理和方法，详细介绍了皱褶材料表面形貌控制的机理和主要途径。最后，综述了起皱材料在光学和光加密领域的应用，强调了它们在这些领域的新兴用途和潜力。

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引用次数: 0