Nano Today最新文献_第6页

Lipid peroxidation in macrophages essentially contributes to the development of lung fibrosis

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-03 DOI: 10.1016/j.nantod.2024.102612

Guangzhe Zheng , Jie Zhang , Jin He , Xi Zhou , Huazhong Li , Lingguo Bu , Bingxue Nie , Juan Ma , Xingyi Wang , Sijin Liu , Shuping Zhang , Yu Qi , Changwen Zhang

Particle-induced pulmonary fibrosis is a common health threat issue, which gives rise to considerable morbidity and even death worldwide. Nonetheless, the roles and underlying molecular mechanisms for different types of cells in driving fibroblast transformation remain elusive. Growing evidence suggests that macrophages crucially determine the initiation of fibroblast transformation through the well-known pro-inflammatory responses and inappropriate repair of inflammation. Encouragingly, we here observed remarkable lipid peroxidation (LPO) in macrophages in bronchoalveolar lavage fluid (BALF) from patients with pneumoconiosis (namely occupational dust-induced pulmonary fibrosis) in comparison to lower levels of LPO in BALF macrophages from the control individuals without pulmonary fibrosis. To corroborate these observations, we examined LPO and the downstream events (including ferroptosis and fibroblast activation) in vitro and in vivo. Strikingly, macrophages exhibited differential responses to diverse particles, and the most remarkable LPO was observed in cells upon exposure to graphene oxide nanosheets (GON), a fundamental composition of carbon-based airborne fine particles, relative to other widely spread particles, such as SiO₂ and Fe₂O₃. The subsequent mechanistic investigations revealed that GON enhanced the induction of transforming growth factor-beta 1, a decisive cytokine in promoting lung fibrosis, accounting for reinforced fibroblast activation. Animal experiments further validated GON-induced LPO in macrophages and fibroblast activation. This study opens a new avenue to understand particle-induced lung fibrosis, and also pinpoints the therapeutic significance of macrophagic LPO.

{"title":"Lipid peroxidation in macrophages essentially contributes to the development of lung fibrosis","authors":"Guangzhe Zheng , Jie Zhang , Jin He , Xi Zhou , Huazhong Li , Lingguo Bu , Bingxue Nie , Juan Ma , Xingyi Wang , Sijin Liu , Shuping Zhang , Yu Qi , Changwen Zhang","doi":"10.1016/j.nantod.2024.102612","DOIUrl":"10.1016/j.nantod.2024.102612","url":null,"abstract":"<div><div>Particle-induced pulmonary fibrosis is a common health threat issue, which gives rise to considerable morbidity and even death worldwide. Nonetheless, the roles and underlying molecular mechanisms for different types of cells in driving fibroblast transformation remain elusive. Growing evidence suggests that macrophages crucially determine the initiation of fibroblast transformation through the well-known pro-inflammatory responses and inappropriate repair of inflammation. Encouragingly, we here observed remarkable lipid peroxidation (LPO) in macrophages in bronchoalveolar lavage fluid (BALF) from patients with pneumoconiosis (namely occupational dust-induced pulmonary fibrosis) in comparison to lower levels of LPO in BALF macrophages from the control individuals without pulmonary fibrosis. To corroborate these observations, we examined LPO and the downstream events (including ferroptosis and fibroblast activation) <em>in vitro</em> and <em>in vivo</em>. Strikingly, macrophages exhibited differential responses to diverse particles, and the most remarkable LPO was observed in cells upon exposure to graphene oxide nanosheets (GON), a fundamental composition of carbon-based airborne fine particles, relative to other widely spread particles, such as SiO<sub>2</sub> and Fe<sub>2</sub>O<sub>3</sub>. The subsequent mechanistic investigations revealed that GON enhanced the induction of transforming growth factor-beta 1, a decisive cytokine in promoting lung fibrosis, accounting for reinforced fibroblast activation. Animal experiments further validated GON-induced LPO in macrophages and fibroblast activation. This study opens a new avenue to understand particle-induced lung fibrosis, and also pinpoints the therapeutic significance of macrophagic LPO.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102612"},"PeriodicalIF":13.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic labeling of physically tunable hydrogel-induced mesenchymal stem cell spheroids with IONPs for MRI tracking and bone regeneration

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-31 DOI: 10.1016/j.nantod.2024.102620

Jia Yan , Hanbang Chen , Yuyao Pan , Yue Yan , Shijia Tang , Qiao Zhou , Ke Hu , Zhaobin Guo , Ning Gu , Feimin Zhang

Bone tissue engineering based on seed cells, biomimetic scaffolds and growth factors emerges as a novel therapeutic option for bone defect. The survival, retention, and function of seed cells after implantation into the defect area are crucial for bone tissue regeneration. However, conventional transplantation of seed cells has limitations such as insufficient transplantation efficiency, survival rate, and cell function. Non-invasive monitoring of engrafted cells to dynamically acquire their growth and differentiation information in vivo presents a challenge in developing tissue engineering applications. Here, we reported magnetically labeled stem cell spheroids induced by physically tunable hydrogel for magnetic resonance imaging (MRI) tracking and bone regeneration. The magnetic stem cell spheroids, integrating spheroid cultivation with the magnetic responsiveness of iron oxide nanoparticles, demonstrated enhanced osteogenic functionality and MRI visibility. This approach is anticipated to facilitate dynamic non-invasive monitoring of cell survival, differentiation, and other status in tissue engineering complexes, thereby expanding its application in visualizing bone defect restoration.

{"title":"Magnetic labeling of physically tunable hydrogel-induced mesenchymal stem cell spheroids with IONPs for MRI tracking and bone regeneration","authors":"Jia Yan , Hanbang Chen , Yuyao Pan , Yue Yan , Shijia Tang , Qiao Zhou , Ke Hu , Zhaobin Guo , Ning Gu , Feimin Zhang","doi":"10.1016/j.nantod.2024.102620","DOIUrl":"10.1016/j.nantod.2024.102620","url":null,"abstract":"<div><div>Bone tissue engineering based on seed cells, biomimetic scaffolds and growth factors emerges as a novel therapeutic option for bone defect. The survival, retention, and function of seed cells after implantation into the defect area are crucial for bone tissue regeneration. However, conventional transplantation of seed cells has limitations such as insufficient transplantation efficiency, survival rate, and cell function. Non-invasive monitoring of engrafted cells to dynamically acquire their growth and differentiation information <em>in vivo</em> presents a challenge in developing tissue engineering applications. Here, we reported magnetically labeled stem cell spheroids induced by physically tunable hydrogel for magnetic resonance imaging (MRI) tracking and bone regeneration. The magnetic stem cell spheroids, integrating spheroid cultivation with the magnetic responsiveness of iron oxide nanoparticles, demonstrated enhanced osteogenic functionality and MRI visibility. This approach is anticipated to facilitate dynamic non-invasive monitoring of cell survival, differentiation, and other status in tissue engineering complexes, thereby expanding its application in visualizing bone defect restoration.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102620"},"PeriodicalIF":13.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal H2S generation promotes the function restoration of spinal cord from acute injury

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-31 DOI: 10.1016/j.nantod.2024.102625

Yihan Chen , Yuanqing Ding , Min Ge , Ya-Xuan Zhu , Yanling You , Zhixin Chen , Yiming Tao , Rong Xie , Han Lin , Jianlin Shi

Spinal cord injury (SCI) refers to either a temporary or permanent damage to the spinal cord caused by external forces, which frequently leads to the acute or sustained impairment on the motor and sensory functions of spinal cord and several chronic systemic complications. Current clinical interventions fail to meet the therapeutic needs in a satisfactory way due to the limited efficacy associated with the blood-spinal cord barrier (BSCB). Here, we propose a strategy for the treatment of spinal cord injury (SCI) using a NIR photothermal-controlled release gas nano-generator based on silicene (SNS) nanosheets. This nano gas-generator greatly promotes nerve regeneration attributing to the physiological effects of H₂S, including the inhibition on inflammation and oxidative stress, protections of nerve cells from the injury, promotion of neuron formation and reduction of glial scar formation. The results show that H₂S-generator is capable of reducing the expressions of activated microglia macrophages and pro-inflammatory cytokines via the NF-κB pathway in SCI mice, which significantly promotes the axon regeneration and functional recovery after SCI. The sustained effectiveness of the generator in the repair of SCI offers a promising prospect in the treatments of a range of neuro-degenerations in addition to spinal cord injury, such as Parkinson's disease and Alzheimer's disease.

{"title":"Photothermal H2S generation promotes the function restoration of spinal cord from acute injury","authors":"Yihan Chen , Yuanqing Ding , Min Ge , Ya-Xuan Zhu , Yanling You , Zhixin Chen , Yiming Tao , Rong Xie , Han Lin , Jianlin Shi","doi":"10.1016/j.nantod.2024.102625","DOIUrl":"10.1016/j.nantod.2024.102625","url":null,"abstract":"<div><div>Spinal cord injury (SCI) refers to either a temporary or permanent damage to the spinal cord caused by external forces, which frequently leads to the acute or sustained impairment on the motor and sensory functions of spinal cord and several chronic systemic complications. Current clinical interventions fail to meet the therapeutic needs in a satisfactory way due to the limited efficacy associated with the blood-spinal cord barrier (BSCB). Here, we propose a strategy for the treatment of spinal cord injury (SCI) using a NIR photothermal-controlled release gas nano-generator based on silicene (SNS) nanosheets. This nano gas-generator greatly promotes nerve regeneration attributing to the physiological effects of H<sub>2</sub>S, including the inhibition on inflammation and oxidative stress, protections of nerve cells from the injury, promotion of neuron formation and reduction of glial scar formation. The results show that H<sub>2</sub>S-generator is capable of reducing the expressions of activated microglia macrophages and pro-inflammatory cytokines via the NF-κB pathway in SCI mice, which significantly promotes the axon regeneration and functional recovery after SCI. The sustained effectiveness of the generator in the repair of SCI offers a promising prospect in the treatments of a range of neuro-degenerations in addition to spinal cord injury, such as Parkinson's disease and Alzheimer's disease.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102625"},"PeriodicalIF":13.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hafnium oxide-based sensitizer with radiation-triggered cuproptosis for radiotherapy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-31 DOI: 10.1016/j.nantod.2024.102626

Xue Wang , Dongmei Wang , You Liao , Xihong Guo , Qingwei Song , Wenchao Liu , Chenglu Gu , Shuanglong Du , Baoyun Sun , Zhanjun Gu

Advanced sensitizers hold significant clinical importance in improving precise tumor radiotherapy while minimizing harm to normal tissues. In our work, the HfO₂-based radiosensitizer (ES@HM-HfO₂:Cu) is developed, in which Cu ions are doped in the shell of the HfO₂ nanocapsules, and elesclomol (ES), the Cu ionophore, is filled in the hollow mesoporous structure. Following the X-ray irradiation, ES@HM-HfO₂:Cu nanocapsules with high-energy deposition effect enable precise and controllable release of Cu ions within the tumor to trigger cuproptosis, exerting dual sensitization outcomes. Consequently, the ES@HM-HfO₂:Cu, leveraging the advantage of cuproptosis activation, achieves a tumor inhibition rate of 77.9 % with no apparent toxicity. Notably, the cuproptosis induced by the released Cu ions from ES@HM-HfO₂:Cu nanocapsules under X-ray irradiation reinforces the sensitization of HM-HfO₂ by promoting mitochondrial lipoylated protein aggregation and iron-sulfur cluster protein loss. Hence, the innovative HfO₂-based radioenhancer achieves intensified radiosensitization through X-ray-responsive cuproptosis, offering profound medical implications for advancing clinical radiotherapy.

{"title":"Hafnium oxide-based sensitizer with radiation-triggered cuproptosis for radiotherapy","authors":"Xue Wang , Dongmei Wang , You Liao , Xihong Guo , Qingwei Song , Wenchao Liu , Chenglu Gu , Shuanglong Du , Baoyun Sun , Zhanjun Gu","doi":"10.1016/j.nantod.2024.102626","DOIUrl":"10.1016/j.nantod.2024.102626","url":null,"abstract":"<div><div>Advanced sensitizers hold significant clinical importance in improving precise tumor radiotherapy while minimizing harm to normal tissues. In our work, the HfO<sub>2</sub>-based radiosensitizer (ES@HM-HfO<sub>2</sub>:Cu) is developed, in which Cu ions are doped in the shell of the HfO<sub>2</sub> nanocapsules, and elesclomol (ES), the Cu ionophore, is filled in the hollow mesoporous structure. Following the X-ray irradiation, ES@HM-HfO<sub>2</sub>:Cu nanocapsules with high-energy deposition effect enable precise and controllable release of Cu ions within the tumor to trigger cuproptosis, exerting dual sensitization outcomes. Consequently, the ES@HM-HfO<sub>2</sub>:Cu, leveraging the advantage of cuproptosis activation, achieves a tumor inhibition rate of 77.9 % with no apparent toxicity. Notably, the cuproptosis induced by the released Cu ions from ES@HM-HfO<sub>2</sub>:Cu nanocapsules under X-ray irradiation reinforces the sensitization of HM-HfO<sub>2</sub> by promoting mitochondrial lipoylated protein aggregation and iron-sulfur cluster protein loss. Hence, the innovative HfO<sub>2</sub>-based radioenhancer achieves intensified radiosensitization through X-ray-responsive cuproptosis, offering profound medical implications for advancing clinical radiotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102626"},"PeriodicalIF":13.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid nanoparticles produce chimeric antigen receptor macrophages (CAR-M) in situ for the treatment of solid tumors

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-31 DOI: 10.1016/j.nantod.2024.102610

Jing-e Zhou , Ziyu Zhou , Zhehao Wang , Lei Sun , Fubing Li , Yu Tang , Rui Liu , JiaHui Liu , Xiaobin Zheng , Lei Yu , Nan Xu , Jing Wang , Zhang Zhang , Qiang Xu , Taiwei Sun , Ceshi Chen , Zhiqiang Yan

Chimeric antigen receptor-macrophage (CAR-M) therapy has shown significant promise for solid tumor treatment. However, its clinical implementation faces challenges due to the intricate ex vivo manufacture procedures involved. Given that the nano drug delivery system (NDDS) is readily taken up by macrophages in vivo, we here propose a convenient approach for in situ CAR-M generation. We first developed lipid nanoparticles loaded with Trop2-CAR plasmid DNA (LNP/CAR Trop2). In vivo experiments showed that LNP/CAR Trop2 could transfect macrophages and produce CAR-M following either intravenous or intratumoral injection. Notably, the majority of CAR-M displayed an M1 phenotype, resulting in the selective elimination of Trop2-overexpressing tumor cells and a reduction in tumor volume in tumor-bearing mice. Furthermore, the produced CAR-M in situ promoted the proliferation of NK cells and CD8 + T cells, further augmenting their anti-tumor effect. This strategy transforms the inherent disadvantage of NDDSs being easily taken up by macrophages into an advantage, enabling the generation of CAR-M in situ and circumventing the complex preparation process ex vivo. This study will improve the convenience and practicality of clinical use of CAR-M and provide a new approach for solid tumors therapy.

{"title":"Lipid nanoparticles produce chimeric antigen receptor macrophages (CAR-M) in situ for the treatment of solid tumors","authors":"Jing-e Zhou , Ziyu Zhou , Zhehao Wang , Lei Sun , Fubing Li , Yu Tang , Rui Liu , JiaHui Liu , Xiaobin Zheng , Lei Yu , Nan Xu , Jing Wang , Zhang Zhang , Qiang Xu , Taiwei Sun , Ceshi Chen , Zhiqiang Yan","doi":"10.1016/j.nantod.2024.102610","DOIUrl":"10.1016/j.nantod.2024.102610","url":null,"abstract":"<div><div>Chimeric antigen receptor-macrophage (CAR-M) therapy has shown significant promise for solid tumor treatment. However, its clinical implementation faces challenges due to the intricate ex vivo manufacture procedures involved. Given that the nano drug delivery system (NDDS) is readily taken up by macrophages in vivo, we here propose a convenient approach for in situ CAR-M generation. We first developed lipid nanoparticles loaded with Trop2-CAR plasmid DNA (LNP/CAR Trop2). In vivo experiments showed that LNP/CAR Trop2 could transfect macrophages and produce CAR-M following either intravenous or intratumoral injection. Notably, the majority of CAR-M displayed an M1 phenotype, resulting in the selective elimination of Trop2-overexpressing tumor cells and a reduction in tumor volume in tumor-bearing mice. Furthermore, the produced CAR-M in situ promoted the proliferation of NK cells and CD8 + T cells, further augmenting their anti-tumor effect. This strategy transforms the inherent disadvantage of NDDSs being easily taken up by macrophages into an advantage, enabling the generation of CAR-M in situ and circumventing the complex preparation process ex vivo. This study will improve the convenience and practicality of clinical use of CAR-M and provide a new approach for solid tumors therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102610"},"PeriodicalIF":13.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Convex Lens” of DNA damage: A nanomedicine enhances anti-PD-1 immunotherapy as immunogenic cell death inducer for “cold” melanoma

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-31 DOI: 10.1016/j.nantod.2024.102598

Wenjun Wang , Yu Liu , Dong Chen , Jiajia Pang , Chunyu Lai , Mingbao Gu , Meilun Zhai , Qian Yu , Yang Wang , Xuanwen Bao , Yangyang Li , Xiaomeng Dai , Dong Chen , Peng Zhao , Jinghong Xu , Rui Lei

Immune checkpoint blockade therapy combined with DNA-damaging therapy can enhance antitumor effects; however, for low-immunogenic melanoma, the efficacy is limited due to impaired antigen presentation and T cell dysfunction. Therefore, we have developed a self-assembled nanodrug (C-GaP) containing an ATR inhibitor, ceralasertib, which can block the DNA damage response, along with the metal ion gallium(Ⅲ), which is capable of inducing DNA replication stress, further exerting a cascading amplification effect on DNA damage. The C-GaP nanodrug exhibits a uniform size distribution and demonstrates outstanding performance in inducing DNA damage, inhibiting proliferation, and promoting apoptosis and immunogenic cell death (ICD) in melanoma cells. Further experiments demonstrate that the C-GaP nanodrug inhibits the phosphorylation of Chk1, enhances the expression of γ-H2AX and cleaved caspase3, and inhibits the PI3K-AKT pathway in vitro. Intriguingly, the C-GaP nanodrug induces dendritic cell activation by triggering ICD in melanoma cells and further induces the activation of helper T cells and cytotoxic T cells, which result in significant antitumor effects in vivo. Moreover, the administration of C-GaP elevates the PD-L1 expression in tumors, while the combination therapy of C-GaP nanodrug and an anti-PD-1 antibody achieves better tumor-suppressive efficacy. Therefore, this designed C-GaP nanomedicine exhibits an antitumor effect as an inducer of ICD.

{"title":"“Convex Lens” of DNA damage: A nanomedicine enhances anti-PD-1 immunotherapy as immunogenic cell death inducer for “cold” melanoma","authors":"Wenjun Wang , Yu Liu , Dong Chen , Jiajia Pang , Chunyu Lai , Mingbao Gu , Meilun Zhai , Qian Yu , Yang Wang , Xuanwen Bao , Yangyang Li , Xiaomeng Dai , Dong Chen , Peng Zhao , Jinghong Xu , Rui Lei","doi":"10.1016/j.nantod.2024.102598","DOIUrl":"10.1016/j.nantod.2024.102598","url":null,"abstract":"<div><div>Immune checkpoint blockade therapy combined with DNA-damaging therapy can enhance antitumor effects; however, for low-immunogenic melanoma, the efficacy is limited due to impaired antigen presentation and T cell dysfunction. Therefore, we have developed a self-assembled nanodrug (C-GaP) containing an ATR inhibitor, ceralasertib, which can block the DNA damage response, along with the metal ion gallium(Ⅲ), which is capable of inducing DNA replication stress, further exerting a cascading amplification effect on DNA damage. The C-GaP nanodrug exhibits a uniform size distribution and demonstrates outstanding performance in inducing DNA damage, inhibiting proliferation, and promoting apoptosis and immunogenic cell death (ICD) in melanoma cells. Further experiments demonstrate that the C-GaP nanodrug inhibits the phosphorylation of Chk1, enhances the expression of γ-H2AX and cleaved caspase3, and inhibits the PI3K-AKT pathway <em>in vitro</em>. Intriguingly, the C-GaP nanodrug induces dendritic cell activation by triggering ICD in melanoma cells and further induces the activation of helper T cells and cytotoxic T cells, which result in significant antitumor effects <em>in vivo.</em> Moreover, the administration of C-GaP elevates the PD-L1 expression in tumors, while the combination therapy of C-GaP nanodrug and an anti-PD-1 antibody achieves better tumor-suppressive efficacy. Therefore, this designed C-GaP nanomedicine exhibits an antitumor effect as an inducer of ICD.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102598"},"PeriodicalIF":13.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart multifunctional Cu2O@RuO2 nanozyme for angiogenesis and osteogenesis in periodontitis

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-31 DOI: 10.1016/j.nantod.2024.102624

Yuyang Li , Faheem Muhammad , Xiwen Chen , Deao Gu , Wen Li , Jiayi Tang , Mingyue Cheng , Jiang Du , Shuwei Qiao , Yu Deng , Qing Yu , Hui Wei , Leiying Miao

Nanozymes have emerged as promising nanomaterials for the treatment of inflammation-related diseases by eliminating excessive reactive oxide species (ROS) and immunoregulation. However, persistent inflammation invariably causes severe alveolar destruction in periodontitis; and the alleviation of inflammation alone by neglecting the impairment of vascular functions could not effectively realize periodontal regeneration. Herein, a multifunctional copper-ruthenium oxide-based yolk-shell nanozyme (Cu₂O@RuO₂, CRNC) is designed to promote effective periodontal regeneration. The ruthenium oxide (RuO₂) shell serves to alleviate inflammation by eliminating ROS and triggering macrophage polarization, whereas the cuprous oxide (Cu₂O) core acts as a responsive Cu^2 + nano-reservoir for promoting angiogenesis and osteogenesis. Results demonstrated that CRNC could activate transforming growth factor β/phosphatidylinositol 3-kinase (TGF-β/PI3K) and hypoxia-inducible factors (HIF-1α) signals, aiding angiogenesis in the human umbilical vein endothelial cells and osteogenesis in periodontal ligament stem cells, respectively. The multifunctional CRNC nanozyme successfully decreased periodontal inflammation and ameliorated alveolar regeneration in a periodontitis model. This study provides promising insights into periodontitis treatment by targeting both angiogenesis and osteogenesis.

{"title":"Smart multifunctional Cu2O@RuO2 nanozyme for angiogenesis and osteogenesis in periodontitis","authors":"Yuyang Li , Faheem Muhammad , Xiwen Chen , Deao Gu , Wen Li , Jiayi Tang , Mingyue Cheng , Jiang Du , Shuwei Qiao , Yu Deng , Qing Yu , Hui Wei , Leiying Miao","doi":"10.1016/j.nantod.2024.102624","DOIUrl":"10.1016/j.nantod.2024.102624","url":null,"abstract":"<div><div>Nanozymes have emerged as promising nanomaterials for the treatment of inflammation-related diseases by eliminating excessive reactive oxide species (ROS) and immunoregulation. However, persistent inflammation invariably causes severe alveolar destruction in periodontitis; and the alleviation of inflammation alone by neglecting the impairment of vascular functions could not effectively realize periodontal regeneration. Herein, a multifunctional copper-ruthenium oxide-based yolk-shell nanozyme (Cu<sub>2</sub>O@RuO<sub>2</sub>, CRNC) is designed to promote effective periodontal regeneration. The ruthenium oxide (RuO<sub>2</sub>) shell serves to alleviate inflammation by eliminating ROS and triggering macrophage polarization, whereas the cuprous oxide (Cu<sub>2</sub>O) core acts as a responsive Cu<sup>2 +</sup> nano-reservoir for promoting angiogenesis and osteogenesis. Results demonstrated that CRNC could activate transforming growth factor β/phosphatidylinositol 3-kinase (TGF-β/PI3K) and hypoxia-inducible factors (HIF-1α) signals, aiding angiogenesis in the human umbilical vein endothelial cells and osteogenesis in periodontal ligament stem cells, respectively. The multifunctional CRNC nanozyme successfully decreased periodontal inflammation and ameliorated alveolar regeneration in a periodontitis model. This study provides promising insights into periodontitis treatment by targeting both angiogenesis and osteogenesis.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102624"},"PeriodicalIF":13.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cucurbit[7]uril-achieved supramolecular nanoplatform capable of targeted depletion of specific pathogen for efficient bacterial keratitis therapy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-28 DOI: 10.1016/j.nantod.2024.102614

Mingji Jiang , Xinyi Wang , Yuhui Zhang , Jing Wang , Jing Kang , Bailiang Wang , Alideertu Dong , Yu Liu

Antibacterial supramolecular nanoplatforms have attracted increasing attention in the field of biomedicine owing to their unique properties. Herein, a cucurbit[7]uril-mediated targeted supramolecular nanoparticles (MPPM⸦CB[7]) is developed to enable selective elimination of pathogenic bacteria from complex communities by using atom transfer radical polymerization (ATRP) to graft antibacterial quaternary ammonium salt monomers (1-pentyl-1-quaternary ammonium-3-vinyl-imidazole (PQVI)) and Escherichia coli (E. coli)-targeted glucosamine units (2-(methacrylamido)-glucopyranose, MAG) onto magnetic nanoparticles (MNPs), and then assembling PQVI with cucurbit[7]uril (CB[7]) via host-guest complexation. Interestingly, MPPM⸦CB[7] host–guest complex exhibits enhanced targeting toward E. coli as compared to MPPM, and the antibacterial activity is turned on through the disassembly of the MPPM⸦CB[7] host–guest complex upon the addition of competitive amantadine (AD) in situ, accompanied by efficient antibacterial performance against pathogenic bacteria Escherichia coli K12 BW25113 (10⁷ colony-forming units, 99.99 %) without harming the probiotic members Lactococcus lactis ATCC 11454 (L. lactis). Particularly, high in vivo therapeutic effectiveness is achieved in E. coli and L. lactis-induced bacterial keratitis. Besides, the magnetic recovery of MPPM reduces its residue in the body, thereby lowering the potential side effects. This CB[7]-mediated supramolecular nanoparticles may provide a new strategy for treatment of ocular disease and have the potential to replace antibiotic treatment.

{"title":"Cucurbit[7]uril-achieved supramolecular nanoplatform capable of targeted depletion of specific pathogen for efficient bacterial keratitis therapy","authors":"Mingji Jiang , Xinyi Wang , Yuhui Zhang , Jing Wang , Jing Kang , Bailiang Wang , Alideertu Dong , Yu Liu","doi":"10.1016/j.nantod.2024.102614","DOIUrl":"10.1016/j.nantod.2024.102614","url":null,"abstract":"<div><div>Antibacterial supramolecular nanoplatforms have attracted increasing attention in the field of biomedicine owing to their unique properties. Herein, a cucurbit[7]uril-mediated targeted supramolecular nanoparticles (MPPM⸦CB[7]) is developed to enable selective elimination of pathogenic bacteria from complex communities by using atom transfer radical polymerization (ATRP) to graft antibacterial quaternary ammonium salt monomers (1-pentyl-1-quaternary ammonium-3-vinyl-imidazole (PQVI)) and <em>Escherichia coli</em> (<em>E. coli</em>)-targeted glucosamine units (2-(methacrylamido)-glucopyranose, MAG) onto magnetic nanoparticles (MNPs), and then assembling PQVI with cucurbit[7]uril (CB[7]) via host-guest complexation. Interestingly, MPPM⸦CB[7] host–guest complex exhibits enhanced targeting toward <em>E. coli</em> as compared to MPPM<em>,</em> and the antibacterial activity is turned on through the disassembly of the MPPM⸦CB[7] host–guest complex upon the addition of competitive amantadine (AD) <em>in situ</em>, accompanied by efficient antibacterial performance against pathogenic bacteria <em>Escherichia coli</em> K12 BW25113 (10<sup>7</sup> colony-forming units, 99.99 %) without harming the probiotic members <em>Lactococcus lactis</em> ATCC 11454 (<em>L. lactis</em>). Particularly, high <em>in vivo</em> therapeutic effectiveness is achieved in <em>E. coli</em> and <em>L. lactis</em>-induced bacterial keratitis. Besides, the magnetic recovery of MPPM reduces its residue in the body, thereby lowering the potential side effects. This CB[7]-mediated supramolecular nanoparticles may provide a new strategy for treatment of ocular disease and have the potential to replace antibiotic treatment.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102614"},"PeriodicalIF":13.2,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-driven dynamic dual-network structure enables hydroplastic polymers with ultrahigh strength and tunable performance

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-28 DOI: 10.1016/j.nantod.2024.102617

Zhen Huang , Penghao Sun , Fuhao Dong , Mujaheed Halliru Saad , He Liu , Xu Xu , Can Jin

Hydroplastic polymers have attracted much attention due to their good combination of hydroformability and environmental sustainability. However, the instability of the network structure of hydroplastic polymers constructed from a single non-covalent physical interaction makes it challenging to achieve satisfactory mechanical properties and hydroforming simultaneously. Herein, a cellulose hydroplastic polymer (Cel-hydroplastic) was proposed that is fabricated by constructing a dynamic dual cross-linking network (boronic ester and hydrogen bonds) between cellulose nanofibers (CNF) and synthetic copolymer containing a catechol structure (PHD). Notably, CNF promotes water-driven reorganization of the dynamic dual network, which allows Cel-hydroplastic to switch arbitrarily between 2D and 3D shapes. Meanwhile, introducing CNF enables Cel-hydroplastic with high mechanical strength (tensile strength: 128.30 MPa dry; 44.50 MPa at relative humidity 90 %). Furthermore, Cel-hydroplastic can be easily recycled and efficiently biodegraded in natural environments. Overall, these outstanding properties position Cel-hydroplastic as a promising candidate for the next generation of environmentally friendly materials.

{"title":"Water-driven dynamic dual-network structure enables hydroplastic polymers with ultrahigh strength and tunable performance","authors":"Zhen Huang , Penghao Sun , Fuhao Dong , Mujaheed Halliru Saad , He Liu , Xu Xu , Can Jin","doi":"10.1016/j.nantod.2024.102617","DOIUrl":"10.1016/j.nantod.2024.102617","url":null,"abstract":"<div><div>Hydroplastic polymers have attracted much attention due to their good combination of hydroformability and environmental sustainability. However, the instability of the network structure of hydroplastic polymers constructed from a single non-covalent physical interaction makes it challenging to achieve satisfactory mechanical properties and hydroforming simultaneously. Herein, a cellulose hydroplastic polymer (Cel-hydroplastic) was proposed that is fabricated by constructing a dynamic dual cross-linking network (boronic ester and hydrogen bonds) between cellulose nanofibers (CNF) and synthetic copolymer containing a catechol structure (PHD). Notably, CNF promotes water-driven reorganization of the dynamic dual network, which allows Cel-hydroplastic to switch arbitrarily between 2D and 3D shapes. Meanwhile, introducing CNF enables Cel-hydroplastic with high mechanical strength (tensile strength: 128.30 MPa dry; 44.50 MPa at relative humidity 90 %). Furthermore, Cel-hydroplastic can be easily recycled and efficiently biodegraded in natural environments. Overall, these outstanding properties position Cel-hydroplastic as a promising candidate for the next generation of environmentally friendly materials.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102617"},"PeriodicalIF":13.2,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered bacterium-nanomedicine complexes in cancer therapy: Designs, applications and challenges

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-12-27 DOI: 10.1016/j.nantod.2024.102623

Zhongming Jie , Xiaoli Yan , Bingyan Xiong , Jianlin Shi

In recent years, nanomedicines have shown extensive potential applications in tumor therapy, which, however, still suffer from various drawbacks such as unsatisfactory targeting efficiency, insufficient tumor penetration, and serious side effects, leading to the greatly limited therapeutic effectiveness of tumors and impeded development of nanocatalytic medicine. In contrast, engineered bacteria and their secretions exhibit promising characteristics of selectively targeting the tumor microenvironments and stimulating robust immune responses. Nonetheless, as a new type of treatment, bacterium-based therapeutics still faces critical issues such as bio-safety and suboptimal efficacies. Nowadays, an increasing number of studies have confirmed that the combination between nanomedicines and engineered bacteria can perfectly highlight the advantages of both approaches, and furthermore, present the synergistic potentials between them based on their respective strengths, thus providing great possibilities for future cancer treatments. In order to promote the advance of this research field, we review the most recent progresses in the field by introducing various types of complexes between engineered bacteria or their metabolites and nanomedicines, as well as the synergetic mechanisms of actions in tumor therapy. Additionally, the key issues in the existing field and their future prospects are discussed and prospected to further aid the development of this field.

{"title":"Engineered bacterium-nanomedicine complexes in cancer therapy: Designs, applications and challenges","authors":"Zhongming Jie , Xiaoli Yan , Bingyan Xiong , Jianlin Shi","doi":"10.1016/j.nantod.2024.102623","DOIUrl":"10.1016/j.nantod.2024.102623","url":null,"abstract":"<div><div>In recent years, nanomedicines have shown extensive potential applications in tumor therapy, which, however, still suffer from various drawbacks such as unsatisfactory targeting efficiency, insufficient tumor penetration, and serious side effects, leading to the greatly limited therapeutic effectiveness of tumors and impeded development of nanocatalytic medicine. In contrast, engineered bacteria and their secretions exhibit promising characteristics of selectively targeting the tumor microenvironments and stimulating robust immune responses. Nonetheless, as a new type of treatment, bacterium-based therapeutics still faces critical issues such as bio-safety and suboptimal efficacies. Nowadays, an increasing number of studies have confirmed that the combination between nanomedicines and engineered bacteria can perfectly highlight the advantages of both approaches, and furthermore, present the synergistic potentials between them based on their respective strengths, thus providing great possibilities for future cancer treatments. In order to promote the advance of this research field, we review the most recent progresses in the field by introducing various types of complexes between engineered bacteria or their metabolites and nanomedicines, as well as the synergetic mechanisms of actions in tumor therapy. Additionally, the key issues in the existing field and their future prospects are discussed and prospected to further aid the development of this field.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102623"},"PeriodicalIF":13.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0