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In-situ TEM/STEM observations of intermetallic growth and reverse transformation of ultra-fine bainitic steel

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-12 DOI: 10.1016/j.nantod.2025.102637

Aleksandra Królicka , Malwina Sikora , Francisca G. Caballero , Andrzej M. Żak

Advanced bainitic steels are an intensively developing research field for demanding industrial applications. The novel grade cementite-free, ultra-fine BainNiAlCu bainitic steel was designed to introduce intermetallic strengthening at elevated temperatures. The principal aim of the research was to understand the sequence of precipitation phenomena and decomposition mechanisms of the metastable bainitic structure as a function of temperature. The studies used the MEMS heating holder and dynamic electron microscopy STEM/TEM observations. The applied thermal cycles enabled the observation of the precipitation processes of the B2-ordered intermetallic phase and the reverse transformation of the bainitic structure into austenite. The dynamic precipitation processes of the L12 and B2 phases were evaluated as a function of temperature, where the most intensive precipitation of the B2 phase occurred at 550 °C. The metastable bainitic matrix was thermally stable up to 500 °C, then decomposition processes were observed. Moreover, the dynamic processes of reverted austenite growth are observed at 650 °C. Austenite growth was noticed at 700 °C at the previous prior austenite grain boundary and may constitute a premise for the “austenite memory” effect. The designed steel is characterized by enhanced thermal stability compared to conventional bainitic steels and indicates the promising alloy design concept for advanced steels. It was confirmed, that in-situ electron microscopy provides an immense capability for better understanding the crucial solid-phase phenomena.

{"title":"In-situ TEM/STEM observations of intermetallic growth and reverse transformation of ultra-fine bainitic steel","authors":"Aleksandra Królicka , Malwina Sikora , Francisca G. Caballero , Andrzej M. Żak","doi":"10.1016/j.nantod.2025.102637","DOIUrl":"10.1016/j.nantod.2025.102637","url":null,"abstract":"<div><div>Advanced bainitic steels are an intensively developing research field for demanding industrial applications. The novel grade cementite-free, ultra-fine BainNiAlCu bainitic steel was designed to introduce intermetallic strengthening at elevated temperatures. The principal aim of the research was to understand the sequence of precipitation phenomena and decomposition mechanisms of the metastable bainitic structure as a function of temperature. The studies used the MEMS heating holder and dynamic electron microscopy STEM/TEM observations. The applied thermal cycles enabled the observation of the precipitation processes of the B2-ordered intermetallic phase and the reverse transformation of the bainitic structure into austenite. The dynamic precipitation processes of the L12 and B2 phases were evaluated as a function of temperature, where the most intensive precipitation of the B2 phase occurred at 550 °C. The metastable bainitic matrix was thermally stable up to 500 °C, then decomposition processes were observed. Moreover, the dynamic processes of reverted austenite growth are observed at 650 °C. Austenite growth was noticed at 700 °C at the previous prior austenite grain boundary and may constitute a premise for the “austenite memory” effect. The designed steel is characterized by enhanced thermal stability compared to conventional bainitic steels and indicates the promising alloy design concept for advanced steels. It was confirmed, that in-situ electron microscopy provides an immense capability for better understanding the crucial solid-phase phenomena.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102637"},"PeriodicalIF":13.2,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High spatiotemporal resolution transmission electron microscopy and diffraction: Progress from subnanosecond laser-induced structural dynamics to femtosecond quantum tomography

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-11 DOI: 10.1016/j.nantod.2025.102638

Sergei A. Aseyev , Boris N. Mironov , Denis G. Poydashev , Evgeny A. Ryabov , R.J. Dwayne Miller , Zheng Li , Ming Zhang , Anatoly A. Ischenko

The use of short photoelectron pulses, pioneered in the 1980s, opened up the possibility of studying structural dynamics with high spatiotemporal resolution. The combination of nano-pico-femtosecond lasers with electron-based technology has become extremely fruitful for observing the behavior of atoms and molecules on their natural length and time scales. In imaging mode, this concept soon led to the creation of 4D transmission electron microscopy. In the electron diffraction mode, the achievement of ultrabright electron sources provided a unique opportunity to shoot molecular movies with atomic resolution. These sources are at their fundamental space charge limit with sufficient brightness to literally light up atomic motions. The high sensitivity of this approach, combined with low radiation damage, made it possible to atomically resolve reaction dynamics with nanograms of material. In contrast to the X-ray free electron lasers (XFELs), the development of ultrabright electron sources made it possible to conduct experiments on very thin films of promising materials in small-scale facilities in standard laboratories. The extension to quantum tomography has recently opened a new page in the study of matter using short electron bunches. Here we review the development of ultrafast transmission electron microscopy and diffraction techniques that enable detection of structural dynamics on the primary timescales.

{"title":"High spatiotemporal resolution transmission electron microscopy and diffraction: Progress from subnanosecond laser-induced structural dynamics to femtosecond quantum tomography","authors":"Sergei A. Aseyev , Boris N. Mironov , Denis G. Poydashev , Evgeny A. Ryabov , R.J. Dwayne Miller , Zheng Li , Ming Zhang , Anatoly A. Ischenko","doi":"10.1016/j.nantod.2025.102638","DOIUrl":"10.1016/j.nantod.2025.102638","url":null,"abstract":"<div><div>The use of short photoelectron pulses, pioneered in the 1980s, opened up the possibility of studying structural dynamics with high spatiotemporal resolution. The combination of nano-pico-femtosecond lasers with electron-based technology has become extremely fruitful for observing the behavior of atoms and molecules on their natural length and time scales. In imaging mode, this concept soon led to the creation of 4D transmission electron microscopy. In the electron diffraction mode, the achievement of ultrabright electron sources provided a unique opportunity to shoot molecular movies with atomic resolution. These sources are at their fundamental space charge limit with sufficient brightness to literally light up atomic motions. The high sensitivity of this approach, combined with low radiation damage, made it possible to atomically resolve reaction dynamics with nanograms of material. In contrast to the X-ray free electron lasers (XFELs), the development of ultrabright electron sources made it possible to conduct experiments on very thin films of promising materials in small-scale facilities in standard laboratories. The extension to quantum tomography has recently opened a new page in the study of matter using short electron bunches. Here we review the development of ultrafast transmission electron microscopy and diffraction techniques that enable detection of structural dynamics on the primary timescales.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102638"},"PeriodicalIF":13.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold beer-inspired multifunctional nanozyme for ischemic stroke with rapid thrombus clearance and long-lasting hydrogen therapy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-11 DOI: 10.1016/j.nantod.2025.102636

Jinlu Wei , Zhibin Zhou , Xinyue Pu , Xuefei Wu , Yuyang Zhang , Tingting Zhong , Wenjing Huang , Zhiwei Zhong , Xiaolei Wang

Ischemic stroke is a thrombus-inflammatory disease caused by cerebral vascular blockage. The narrow treatment window presents challenges for timely intervention and neurological recovery. Inspired by cold beer, we developed a multifunctional nanozyme (CREKA-MOF@Pd/H₂-uPA, denoted as CMPd(H)U). After injection, CMPd(H)U efficiently targeted the thrombus and combined with gas therapy to expedite thrombolysis and restore blood flow. Additionally, CMPd(H)U released hydrogen (H₂) to eliminate reactive oxygen species (ROS), thereby mitigating reperfusion injury. Furthermore, CMPd(H)U demonstrated anti-inflammatory and neuroprotective properties by modulating microglial polarization towards the M2 phenotype and inhibiting neuronal pyroptosis. Animal behavioral experiments confirmed the effectiveness of the system in promoting neuromotor function recovery post-stroke.

引用次数: 0

Scalable liposomes functionalization via membrane lipid exchange mechanisms

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-10 DOI: 10.1016/j.nantod.2025.102630

Xizi Long , Chiho Kataoka-Hamai , Chia-Lun Ho , Wei-Lun Huang , Yi-Ho Kuo , Li-Ting Yang , Wei-Peng Li , Akihiro Okamoto

Extracellular vesicles are pivotal in intercellular communication and hold significant promise for medical applications. However, limitations in their mass production and challenges in replicating their complex functions with artificial liposomes necessitate innovative solutions. We functionalize liposomes by combining the scalable production advantages of artificial liposomes with the vesicle fusion and formation mechanisms of bacteria. By incubating the gram-negative Shewanella oneidensis MR-1, known for its electrochemically active outer membrane cytochromes (OMCs), with liposomes containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine for 24 hours, we achieved a substantial yield of membrane-integrated liposomes (MILs) incorporating OMCs. Circular dichroism spectroscopy confirmed the preservation of redox activity and strong inter-heme exciton coupling in the OMCs. These components were successfully delivered to Escherichia coli K-12 by incubation with MILs, retaining their functionality. Furthermore, the slow membrane exchange process did not result in cellular viability loss or lysis, allowing for the recycling of microbial cells and minimizing contaminants from lysed cells, which is advantageous for scaling up. Building on our previous work where MIL-coated titanium dioxide nanoparticles significantly enhanced radical production and effectively treated orthotopic liver tumors in vivo, our methodology to generate the MIL has promising potential to spearhead novel integrations of synthetic and biological systems for medical technologies.

{"title":"Scalable liposomes functionalization via membrane lipid exchange mechanisms","authors":"Xizi Long , Chiho Kataoka-Hamai , Chia-Lun Ho , Wei-Lun Huang , Yi-Ho Kuo , Li-Ting Yang , Wei-Peng Li , Akihiro Okamoto","doi":"10.1016/j.nantod.2025.102630","DOIUrl":"10.1016/j.nantod.2025.102630","url":null,"abstract":"<div><div>Extracellular vesicles are pivotal in intercellular communication and hold significant promise for medical applications. However, limitations in their mass production and challenges in replicating their complex functions with artificial liposomes necessitate innovative solutions. We functionalize liposomes by combining the scalable production advantages of artificial liposomes with the vesicle fusion and formation mechanisms of bacteria. By incubating the gram-negative <em>Shewanella oneidensis</em> MR-1, known for its electrochemically active outer membrane cytochromes (OMCs), with liposomes containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine for 24 hours, we achieved a substantial yield of membrane-integrated liposomes (MILs) incorporating OMCs. Circular dichroism spectroscopy confirmed the preservation of redox activity and strong inter-heme exciton coupling in the OMCs. These components were successfully delivered to <em>Escherichia coli</em> K-12 by incubation with MILs, retaining their functionality. Furthermore, the slow membrane exchange process did not result in cellular viability loss or lysis, allowing for the recycling of microbial cells and minimizing contaminants from lysed cells, which is advantageous for scaling up. Building on our previous work where MIL-coated titanium dioxide nanoparticles significantly enhanced radical production and effectively treated orthotopic liver tumors <em>in vivo</em>, our methodology to generate the MIL has promising potential to spearhead novel integrations of synthetic and biological systems for medical technologies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102630"},"PeriodicalIF":13.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optically-modulated and mechanically-flexible MXene artificial synapses with visible-to-near IR broadband-responsiveness

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-10 DOI: 10.1016/j.nantod.2025.102633

Chung Won Lee , Seung Ju Kim , Han-Kyun Shin , Young-Jun Cho , Changhyeon Yoo , Sang Sub Han , Hyo-Jong Lee , Jung Han Kim , Yeonwoong Jung

The inherent limitations of von Neumann computing associated with its inefficient parallel-processing of massive data become increasingly pronounced in state-of-the-art digital device technologies. Artificial synapses of the human brain-inspired neuromorphic computing are emerging as a viable solution, which demands to explore unconventional materials responsive to a variety of electrical and/or optical stimuli. Herein, we report that solution-processed titanium carbide MXene (Ti₃C₂T_x) exhibits essential characteristics for optoelectronic synapses-based neuromorphic computing. Specifically, it presents optically-triggered synaptic plasticity with memory effects in a broad spectral range, as well as accompanying a large degree of mechanical deformability. By leveraging the optoelectronics-mechanics coupling, we demonstrate that MXene-based devices can simulate vital functionalities demanded in artificial neural networks (ANNs) such as associative learning behaviors and high-accuracy pattern recognition. Furthermore, the operational principle of the MXene optoelectronic synapses is unveiled in the context of the charge trapping/de-trapping mechanism enabled by its processing-introduced bandgap opening.

{"title":"Optically-modulated and mechanically-flexible MXene artificial synapses with visible-to-near IR broadband-responsiveness","authors":"Chung Won Lee , Seung Ju Kim , Han-Kyun Shin , Young-Jun Cho , Changhyeon Yoo , Sang Sub Han , Hyo-Jong Lee , Jung Han Kim , Yeonwoong Jung","doi":"10.1016/j.nantod.2025.102633","DOIUrl":"10.1016/j.nantod.2025.102633","url":null,"abstract":"<div><div>The inherent limitations of von Neumann computing associated with its inefficient parallel-processing of massive data become increasingly pronounced in state-of-the-art digital device technologies. Artificial synapses of the human brain-inspired neuromorphic computing are emerging as a viable solution, which demands to explore unconventional materials responsive to a variety of electrical and/or optical stimuli. Herein, we report that solution-processed titanium carbide MXene (Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>) exhibits essential characteristics for optoelectronic synapses-based neuromorphic computing. Specifically, it presents optically-triggered synaptic plasticity with memory effects in a broad spectral range, as well as accompanying a large degree of mechanical deformability. By leveraging the optoelectronics-mechanics coupling, we demonstrate that MXene-based devices can simulate vital functionalities demanded in artificial neural networks (ANNs) such as associative learning behaviors and high-accuracy pattern recognition. Furthermore, the operational principle of the MXene optoelectronic synapses is unveiled in the context of the charge trapping/de-trapping mechanism enabled by its processing-introduced bandgap opening.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102633"},"PeriodicalIF":13.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of liquid-phase TEM in the fields of electrocatalysis and photocatalysis

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-08 DOI: 10.1016/j.nantod.2024.102629

Yueshuai Wang , Guoyu Huang , Jiarui Wang , Hangyi Zhao , Zhengli Li , Zhihong Zhang , Manling Sui , Yue Lu

The evolution of active sites at the solid-liquid interface plays a decisive role in determining the performance and stability of electrocatalysis and photocatalysis. As a powerful in situ characterization technique, Liquid-Phase Transmission Electron Microscopy (LP-TEM) offers unique opportunities to analyze the dynamic reaction processes at solid-liquid interfaces with nano- or even atomic-scale resolution. In this review, we first trace the development history of LP-TEM technology, highlighting its advantages for elucidating liquid-phase catalytic reaction systems. Integrating electrochemical and light illumination modules into LP-TEM vividly demonstrates the dynamic evolution processes of electrocatalysis and photocatalysis. Furthermore, we systematically summarize and discuss its applications in the electrocatalytic oxygen evolution reaction (OER), electrocatalytic CO₂ reduction reaction (CO₂RR), electrocatalytic oxygen reduction reaction (ORR), and photocatalytic hydrogen production, clarifying their current developmental status. Additionally, we address the limitations and challenges of the current LP-TEM technique, such as spatial resolution and electron beam damage, providing insights for future improvements.

{"title":"Applications of liquid-phase TEM in the fields of electrocatalysis and photocatalysis","authors":"Yueshuai Wang , Guoyu Huang , Jiarui Wang , Hangyi Zhao , Zhengli Li , Zhihong Zhang , Manling Sui , Yue Lu","doi":"10.1016/j.nantod.2024.102629","DOIUrl":"10.1016/j.nantod.2024.102629","url":null,"abstract":"<div><div>The evolution of active sites at the solid-liquid interface plays a decisive role in determining the performance and stability of electrocatalysis and photocatalysis. As a powerful <em>in situ</em> characterization technique, Liquid-Phase Transmission Electron Microscopy (LP-TEM) offers unique opportunities to analyze the dynamic reaction processes at solid-liquid interfaces with nano- or even atomic-scale resolution. In this review, we first trace the development history of LP-TEM technology, highlighting its advantages for elucidating liquid-phase catalytic reaction systems. Integrating electrochemical and light illumination modules into LP-TEM vividly demonstrates the dynamic evolution processes of electrocatalysis and photocatalysis. Furthermore, we systematically summarize and discuss its applications in the electrocatalytic oxygen evolution reaction (OER), electrocatalytic CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR), electrocatalytic oxygen reduction reaction (ORR), and photocatalytic hydrogen production, clarifying their current developmental status. Additionally, we address the limitations and challenges of the current LP-TEM technique, such as spatial resolution and electron beam damage, providing insights for future improvements.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102629"},"PeriodicalIF":13.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143176723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assembled micellar photosensitizers for combating bacterial infections and activating systemic acquired resistance

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-08 DOI: 10.1016/j.nantod.2024.102627

Yinglong Wu , Zunpan She , Xiaodong Zhang , Lihe Sun , Xiaokai Chen , Jingjing Guo , Xinkun Ma , Long Gu , Dongdong Wang , Hongzhong Chen , Fang Zeng , Shuizhu Wu , Yanli Zhao

Bactericides are still the main tools for managing plant diseases, while long-term and large-scale use often brings many problems, such as resistance to the applied chemicals and damage to ecological environment. To address these issues, we develop visible-light-absorbing photosensitizers (TTT and MTTT) with aggregation-induced emission feature, and further assemble them with a cationic surfactant octadecyltrimethylammonium bromide (OTAB) to form the micellar photosensitizer (MTTT@OTAB). The fabricated MTTT@OTAB can target phytopathogen Pseudomonas syringae pv. tomato DC3000 at the infection sites of the model plant Arabidopsis thaliana via electrostatic interactions, and then eliminate them through photodynamic effect under white light irradiation. More importantly, reactive oxygen species (ROS) produced through the photosensitization of MTTT@OTAB can also induce an immune response known as systemic acquired resistance by regulating the ROS-azelaic acid (AzA)- glycerol-3-phosphate (G3P) signaling pathway in Arabidopsis, thereby preventing secondary infections. Collectively, the present study demonstrates the development of photosensitizer systems with robust photodynamic effect under the normal plant growth conditions, which holds great potential as alternatives to the conventional agrochemicals for sustainable protection of agriculture against destructive bacterial infections.

{"title":"Self-assembled micellar photosensitizers for combating bacterial infections and activating systemic acquired resistance","authors":"Yinglong Wu , Zunpan She , Xiaodong Zhang , Lihe Sun , Xiaokai Chen , Jingjing Guo , Xinkun Ma , Long Gu , Dongdong Wang , Hongzhong Chen , Fang Zeng , Shuizhu Wu , Yanli Zhao","doi":"10.1016/j.nantod.2024.102627","DOIUrl":"10.1016/j.nantod.2024.102627","url":null,"abstract":"<div><div>Bactericides are still the main tools for managing plant diseases, while long-term and large-scale use often brings many problems, such as resistance to the applied chemicals and damage to ecological environment. To address these issues, we develop visible-light-absorbing photosensitizers (TTT and MTTT) with aggregation-induced emission feature, and further assemble them with a cationic surfactant octadecyltrimethylammonium bromide (OTAB) to form the micellar photosensitizer (MTTT@OTAB). The fabricated MTTT@OTAB can target phytopathogen <em>Pseudomonas syringae</em> pv. <em>tomato</em> DC3000 at the infection sites of the model plant <em>Arabidopsis thaliana</em> via electrostatic interactions, and then eliminate them through photodynamic effect under white light irradiation. More importantly, reactive oxygen species (ROS) produced through the photosensitization of MTTT@OTAB can also induce an immune response known as systemic acquired resistance by regulating the ROS-azelaic acid (AzA)- glycerol-3-phosphate (G3P) signaling pathway in <em>Arabidopsis</em>, thereby preventing secondary infections. Collectively, the present study demonstrates the development of photosensitizer systems with robust photodynamic effect under the normal plant growth conditions, which holds great potential as alternatives to the conventional agrochemicals for sustainable protection of agriculture against destructive bacterial infections.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102627"},"PeriodicalIF":13.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microalgae-based drug delivery microspheres for treatment of hyperuricemia with renal injury

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-05 DOI: 10.1016/j.nantod.2024.102607

Xiaoyang Liu , Jia Dong , Jiarong Cui , Yixin Zheng , Huiqun Hu , Ruoxi Wang , Kaiyue Wang , Danni Zhong , Hui Huang , Yichun Zheng , Min Zhou

Hyperuricemia is a common metabolic disease caused by an abnormally high level of uric acid (UA) due to excessive production or insufficient renal excretion, which progresses continuously and leads to severe kidney damage. In this study, an oral microsphere strategy (Eug/Lut@HAMA) was developed by encapsulating euglena (Eug) and luteolin (Lut) within methacrylated hyaluronic acid (HAMA) microspheres as a potential treatment for hyperuricemia with renal injury. Eug has UA adsorption capabilities, Lut aids in reducing UA formation, and HAMA microspheres possess adhesive properties. Eug/Lut@HAMA effectively reduced UA levels and provided protective effects against UA-induced reactive oxygen species production and cellular apoptosis. The microspheres demonstrated reduced gastric drug loss, prolonged intestinal retention, and sustained Eug and Lut release. Eug and Lut exhibit complementarity in the treatment of acute/chronic hyperuricemia, with Eug increasing UA excretion and Lut decreasing UA production. Eug/Lut@HAMA offered multiple benefits in improving renal injury, including anti-inflammatory, antioxidant, and anti-fibrotic properties. Additionally, Eug/Lut@HAMA demonstrated long-term biosafety for oral administration. This study presents a novel, effective, and safe approach to managing acute/chronic hyperuricemia with renal injury by reducing UA production and enhancing UA excretion.

{"title":"Microalgae-based drug delivery microspheres for treatment of hyperuricemia with renal injury","authors":"Xiaoyang Liu , Jia Dong , Jiarong Cui , Yixin Zheng , Huiqun Hu , Ruoxi Wang , Kaiyue Wang , Danni Zhong , Hui Huang , Yichun Zheng , Min Zhou","doi":"10.1016/j.nantod.2024.102607","DOIUrl":"10.1016/j.nantod.2024.102607","url":null,"abstract":"<div><div>Hyperuricemia is a common metabolic disease caused by an abnormally high level of uric acid (UA) due to excessive production or insufficient renal excretion, which progresses continuously and leads to severe kidney damage. In this study, an oral microsphere strategy (Eug/Lut@HAMA) was developed by encapsulating euglena (Eug) and luteolin (Lut) within methacrylated hyaluronic acid (HAMA) microspheres as a potential treatment for hyperuricemia with renal injury. Eug has UA adsorption capabilities, Lut aids in reducing UA formation, and HAMA microspheres possess adhesive properties. Eug/Lut@HAMA effectively reduced UA levels and provided protective effects against UA-induced reactive oxygen species production and cellular apoptosis. The microspheres demonstrated reduced gastric drug loss, prolonged intestinal retention, and sustained Eug and Lut release. Eug and Lut exhibit complementarity in the treatment of acute/chronic hyperuricemia, with Eug increasing UA excretion and Lut decreasing UA production. Eug/Lut@HAMA offered multiple benefits in improving renal injury, including anti-inflammatory, antioxidant, and anti-fibrotic properties. Additionally, Eug/Lut@HAMA demonstrated long-term biosafety for oral administration. This study presents a novel, effective, and safe approach to managing acute/chronic hyperuricemia with renal injury by reducing UA production and enhancing UA excretion.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102607"},"PeriodicalIF":13.2,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal imaging-guided sonodynamic therapy for orthotopic liver cancer using a functionalized sonosensitizer

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-04 DOI: 10.1016/j.nantod.2024.102618

Mengxuan Wang , Nisi Zhang , Rui Li , Josquin Foiret , Katherine W. Ferrara , Xiuli Yue , Zhifei Dai

Liver cancer remains a significant global health challenge, with rising incidence rates and limited treatment options, underscoring the urgent need for innovative and effective therapeutic strategies. Sonodynamic therapy (SDT) stands as a promising non-invasive treatment technique, yet its advancement faces challenges due to difficulties in precisely co-localizing the tumor, sonosensitizers, and focused ultrasound (FUS). Additionally, the absence of feasible methods for in vivo detection of reactive oxygen species (ROS) hampers further research and development in this field. Herein, our study introduces a novel sonosensitizer, a phthalocyanine-conjugated mesoporous silicate nanoparticle loaded with allylhydrazine (PAMSN). We confirm that PAMSN not only amplifies the fluorescent signal of phthalocyanine (1.9-fold) but also generates nitrogen gas bubbles via the interaction between allylhydrazine (ALZ) and ROS. This distinct attribute positions PAMSN as a versatile multimodal contrast agent suitable for in vivo tumor imaging and SDT applications. Moreover, we establish a FUS platform that integrates fluorescent and ultrasonic imaging guidance, ensuring the precise delivery of ultrasound to the targeted area. In conjunction with PAMSN, this platform can effectively treat orthotopic liver cancer in a murine model while in vivo monitoring of ROS and detection of cavitation are enabled. In conclusion, PAMSN-mediated SDT with the multimodal imaging-guided SDT platform facilitates a precise and controllable SDT process, providing a promising tool for safer and more effective SDT in clinical tumor treatment.

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引用次数: 0

A tightly coupled electromagnetic-triboelectric hybrid generator for wind energy harvesting and environmental monitoring

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-01-03 DOI: 10.1016/j.nantod.2024.102628

Hanlin Zhou , Zhi Cao , Zhong Lin Wang , Zhiyi Wu

Small distributed wind harvesters, offering flexible deployment, lower costs, and localized power, complement large wind turbines in wind energy utilization. This paper reports a tightly coupled electromagnetic-triboelectric hybrid generator (ETHG). The electromagnetic generator (EMG) component changes the magnetic field by rotating the magnetizing material, while the magnet and coil remain stationary to facilitate close integration with the triboelectric nanogenerator (TENG) component. Furthermore, the output performance of the TENG component is optimized by studying friction materials and electrode. Finally, at a wind speed of 18.28 m/s, the TENG and EMG components can provide open-circuit voltages of 936 V and 10.35 V, and short-circuit currents of 29.6 µA and 4.27 mA, respectively, and can charge a 3.3 mF commercial capacitor to 3.5 V in just 12.1 s. Additionally, the self-powered environmental temperature and humidity monitoring system assisted by the ETHG can continuously transmit environmental temperature and humidity information to receiver at 3-s intervals. This study provides guidance for distributed energy harvesting and has broad application prospects in environmental monitoring and self-powered sensor networks.

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引用次数: 0

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