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Polyelectrolyte nanocomplexes responsive to pathological neuronal discharge realize precise drug delivery for treating acute epilepsy via neurotransmitter homeostasis modulation 多电解质纳米复合物响应病理神经元放电，通过调节神经递质稳态，实现治疗急性癫痫的精确给药

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-10-11 DOI: 10.1016/j.nantod.2025.102916

Xinrui Zhao , Rong Yang , Yage Sun , Wenguang Liu

Abnormal neuronal discharge due to disordered neurotransmitter homeostasis and harsh inflammation in epileptic focus is prone to cause recurrent seizures. However, current difficulties in drug delivery across blood-brain barrier (BBB) and regulation of complex pathological microenvironment hinder complete control of epilepsy with clinical therapies. Herein, a novel microenvironment-responsive drug-loaded polyelectrolyte nanocomplex (HCT-Fu@VB₆) formed by electrostatic self-assembly between tryptophan-modified hydroxypropyl chitosan (HCT) and fucoidan (Fu) with efficient vitamin B₆ (VB₆) loading, is developed for potent epilepsy treating, innovatively aiming to modulate neurotransmitters balance and attenuate the neuroinflammatory responses. Specifically, HCT confers the nanoparticles with specific binding affinity towards L-type amino acid transporter 1 expressed on brain endothelial cells, thereby significantly contributing to enhanced trans-BBB drug delivery efficiency. The fucoidan-containing polyelectrolyte nanocomplexes serve to provide intrinsic antioxidant property. Notably, the prepared polyelectrolyte nanocomplexes are dissociated in response to the mimic pathological neuronal discharges due to disturbed electrostatic equilibrium, facilitating accelerated VB₆ release for enhanced oxidative stress mitigation and effective neurotransmitter homeostasis modulation, acting as a competitive antagonist of ATP-gated purinergic P2RX7. The developed HCT-Fu@VB₆ nanoparticles demonstrate significant therapeutic efficacy as an electrically responsive trans-BBB drug delivery system, remarkably reducing seizure in epileptic rats while maintaining an excellent safety profile.

由于神经递质稳态紊乱和癫痫病灶严重炎症引起的异常神经元放电容易引起反复发作。然而，目前在血脑屏障（BBB）药物传递和复杂病理微环境调控方面的困难阻碍了临床治疗对癫痫的完全控制。本文通过色氨酸修饰的羟丙基壳聚糖（HCT）和高效负载维生素B6 （VB6）的岩藻糖聚糖（Fu）之间的静电自组装形成一种新型微环境响应型载药多电解质纳米复合物（HCT-Fu@VB6），用于有效治疗癫痫，创新地旨在调节神经递质平衡和减轻神经炎症反应。具体来说，HCT赋予纳米颗粒与脑内皮细胞上表达的l型氨基酸转运蛋白1的特异性结合亲和力，从而显著提高了跨血脑屏障给药效率。含岩藻糖苷的聚电解质纳米复合物具有固有的抗氧化性能。值得注意的是，所制备的多电解质纳米复合物在静电平衡被扰乱的模拟病理神经元放电的反应中解离，促进加速VB6的释放，增强氧化应激缓解和有效的神经递质稳态调节，作为atp门控嘌呤能P2RX7的竞争性拮抗剂。开发的HCT-Fu@VB6纳米颗粒作为一种电反应性的跨血脑屏障药物传递系统显示出显著的治疗效果，显著减少癫痫大鼠的癫痫发作，同时保持良好的安全性。

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引用次数: 0

Corrigendum to “Biodegradable multimodal biomaterials with microenvironmental adaptability and orderly delivery of H2S and bFGF for the treatment of spinal cord injury” [Nano Today 66 (2026) 102890] “具有微环境适应性和有序输送H2S和bFGF的可生物降解多模态生物材料用于脊髓损伤治疗”的勘误表[Nano Today 66 (2026) 102890]

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-10-09 DOI: 10.1016/j.nantod.2025.102914

Junqing Huang , Jiamen Shen , Yu Huang , Yanfang Zhao , Yibo Ying , Yanran Bi , Liuxi Chu , Xinwang Ying , Qian Xu , Junpeng Xu , Ping Wu , Jiansong Ji , Zhouguang Wang

引用次数: 0

Tailored apoptotic vesicles promote bone regeneration by stepping on osteoinductive accelerator via ITGA10-AKT signaling activation 定制的凋亡囊泡通过ITGA10-AKT信号激活，通过踩骨诱导加速器促进骨再生

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-10-06 DOI: 10.1016/j.nantod.2025.102912

Yuhe Jiang , Zeying Wang , Ruiyi Guo , Yike Liao , Hao Qiu , Yunsong Liu , Ping Zhang , Yuan Zhu , Wenyue Li , Xiao Zhang , Yongsheng Zhou

Apoptotic vesicles (apoVs) have shown good potential in treating bone disease including osteoporosis. However, the efficient production of highly energetic apoVs is one of the critical limitations for their clinical applications. In this study, we contributed to reconstructing a gradual senescence process in mesenchymal stem cell (MSC)-derived apoVs. Our findings displayed that their essential properties remained consistent throughout replicative aging and individual’s aging. Nevertheless, their protein composition and biological functions were significantly altered by the age of donor. Through proteomic assay, we identified integrin α 10 (ITGA10) as a highly efficient apoV osteoinductivity accelerator in both humans and mice, and have targeted it for apoV customization. On this basis, we demonstrated accelerator-based approaches to prepare amounts of ITGA10-enriched apoVs by magnetic-activated sorting and sonic loading. These engineered apoVs proved effective in ameliorating osteoprotic bone loss. Their osteoinductivity was attributed to the activation of downstream AKT signaling in recipient MSCs by the high content of ITGA10. In summary, we have laid the groundwork for customizing apoVs through an accelerator-based strategy, aiming to obtain superior therapeutic effectors in the field of bone regenerative biomedicine.

凋亡囊泡（apoVs）在治疗骨质疏松等骨病方面显示出良好的潜力。然而，高效生产高能载脂蛋白是其临床应用的关键限制之一。在这项研究中，我们重建了间充质干细胞（MSC）衍生的apoVs的逐渐衰老过程。我们的研究结果表明，它们的基本特性在复制衰老和个体衰老过程中保持一致。然而，它们的蛋白质组成和生物学功能随着供体年龄的变化而显著改变。通过蛋白质组学分析，我们发现整合素α 10 （ITGA10）在人类和小鼠中都是一种高效的apoV骨诱导促进剂，并针对apoV定制。在此基础上，我们展示了基于加速器的方法，通过磁激活分选和声波加载制备大量富含itga10的apov。这些工程化的apov被证明在改善骨质流失方面是有效的。它们的成骨性归因于高含量的ITGA10激活了受体MSCs中的下游AKT信号。综上所述，我们已经通过基于加速器的策略为定制apov奠定了基础，旨在骨再生生物医学领域获得卓越的治疗效果。

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引用次数: 0

Redox-driven mechanoregulation of invasive TNBC cells using poly(tannic acid) nanospheres 利用聚单宁酸纳米球对侵袭性TNBC细胞的氧化还原驱动机制调控

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-10-06 DOI: 10.1016/j.nantod.2025.102907

Minhee Ku , Suhui Jeong , Nara Yoon , Hwain Myeong , Jinwon Kwon , Jaemoon Yang , Sungbaek Seo

Poly(tannic acid) (pTA) nanospheres, assembled from natural tannic acid molecules, exhibit strong intracellular antioxidant activity and effectively modulate the invasive behaviour of triple-negative breast cancer (TNBC) cells. Acting as redox-active nanostructures, pTA nanospheres suppress proliferation and induce mechanoregulatory changes, including altered nuclear morphology, cytoskeletal disassembly, and diminished cell polarity. Specifically, pTA treatment causes spatial mislocalization of MT1-MMP from the invasive front to the perinuclear zone, disrupting its colocalization with F-actin and reducing its matrix-degrading capacity. High-resolution STED and TEM imaging reveal vimentin network collapse and mitochondrial redistribution along microtubules. Metabolic profiling shows a marked decline in oxidative phosphorylation-linked ATP production. Despite these functional disruptions, cleaved caspase-3 remains undetectable, indicating a non-apoptotic, cytostatic state accompanied by autophagy and redox signalling compensation. These findings demonstrate that pTA nanospheres exert redox-driven mechanoregulation in TNBC cells, limiting their invasive potential without inducing cell death, and highlight their promise as a non-lethal nanotherapeutics approach for post-surgical or adjuvant control of metastatic progression.

聚单宁酸（pTA）纳米球由天然单宁酸分子组装而成，具有很强的细胞内抗氧化活性，可有效调节三阴性乳腺癌（TNBC）细胞的侵袭行为。作为氧化还原活性纳米结构，pTA纳米球抑制增殖并诱导机械调节变化，包括核形态改变、细胞骨架解体和细胞极性减弱。具体来说，pTA治疗导致MT1-MMP从侵袭前沿到核周区域的空间错定位，破坏其与f -肌动蛋白的共定位，降低其基质降解能力。高分辨率STED和TEM成像显示静脉蛋白网络崩溃和线粒体沿微管重新分布。代谢分析显示氧化磷酸化相关的ATP产生明显下降。尽管存在这些功能破坏，但切割后的caspase-3仍然无法检测到，这表明caspase-3处于非凋亡、细胞抑制状态，并伴有自噬和氧化还原信号补偿。这些发现表明，pTA纳米球在TNBC细胞中发挥氧化还原驱动的机制调节作用，在不诱导细胞死亡的情况下限制了它们的侵袭潜力，并突出了它们作为手术后或辅助控制转移进展的非致死性纳米治疗方法的前景。

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引用次数: 0

Corrigendum to “Macrophage-targeted polysaccharide nano-immunomodulators with spatial- and time-programmed drug release for cancer therapy” [Nano Today 66 (2026) 102893] “巨噬细胞靶向多糖纳米免疫调节剂用于癌症治疗的空间和时间编程药物释放”的更正[Nano Today 66 (2026) 102893]

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-10-04 DOI: 10.1016/j.nantod.2025.102913

Li Xu , Jiaqian Miao , Danni Xu , Xuan Mo , Junjie Wang , Sisi Chen , Bing Liu , Guangbo Ge , Xinyuan Zhu , Hongping Deng

引用次数: 0

Distinct immunological features of Ferritin and AP205 nanovaccines lead to differing therapeutic outcomes against chronic hepatitis B 铁蛋白和AP205纳米疫苗不同的免疫学特性导致对慢性乙型肝炎不同的治疗结果

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-10-01 DOI: 10.1016/j.nantod.2025.102909

Xiaoxiao Zhou , Wenjun Wang , Yiyuan Zheng , Jiyu Ding , Mingzhao Zhu

Ferritin and AP205 are two well-established representative nanoparticle platforms widely used in vaccine development. However, their immunological properties, vaccine efficacy, and underlying mechanisms remain incompletely characterized. In this study, we systematically compared the immune profiles of Ferritin- and AP205-based nanovaccines, explored their mechanisms of action, and evaluated their efficiency in the AAV-HBV infection mouse model. Our results demonstrated that the AP205 vaccine, which incorporates intrinsic ssRNA as a built-in adjuvant, elicited a stronger antibody response with a balanced IgG1/IgG2c profile. In contrast, the Ferritin vaccine supplemented with extrinsic CpG adjuvant induced an IgG1-biased antibody response. At the T cell level, the AP205 vaccine promoted a more mature germinal center T follicular helper (GC-Tfh) cell response, whereas the Ferritin+CpG vaccine stimulated a stronger Th1 response, likely due to enhanced dendritic cell activation by CpG. We further showed that codelivery of antigen and adjuvant is necessary and sufficient to augment IgG2c response for both platforms. Functionally, although the AP205-preS1 vaccine exhibited superior preventive efficacy against acute AAV-HBV infection compared to the Ferritin-preS1 +CpG vaccine, it showed reduced therapeutic efficacy against chronic AAV-HBV infection, highlighting the importance of Th1 immunity in viral clearance. Together, these findings suggest that the AP205 platform may serve as an effective platform for prophylactic vaccines, while Ferritin+CpG may hold greater potential for therapeutic applications requiring strong Th1 responses, such as chronic hepatitis B (CHB).

铁蛋白和AP205是两种具有代表性的纳米颗粒平台，广泛应用于疫苗开发。然而，它们的免疫学特性、疫苗效力和潜在机制仍不完全清楚。在本研究中，我们系统地比较了基于铁蛋白和ap205的纳米疫苗的免疫特性，探讨了它们的作用机制，并评估了它们在AAV-HBV感染小鼠模型中的有效性。我们的研究结果表明，包含内在ssRNA作为内置佐剂的AP205疫苗引发了更强的抗体反应，具有平衡的IgG1/IgG2c谱。相比之下，铁蛋白疫苗补充外源性CpG佐剂诱导igg1偏向抗体反应。在T细胞水平上，AP205疫苗促进了更成熟的生发中心T滤泡辅助细胞（GC-Tfh）反应，而铁蛋白+CpG疫苗刺激了更强的Th1反应，可能是由于CpG增强了树突状细胞的激活。我们进一步表明，抗原和佐剂的共递送对于增强两种平台的IgG2c应答是必要和充分的。功能上，虽然AP205-preS1疫苗对急性AAV-HBV感染的预防效果优于铁蛋白- pres1 +CpG疫苗，但对慢性AAV-HBV感染的治疗效果却有所降低，这凸显了Th1免疫在病毒清除中的重要性。总之，这些发现表明AP205平台可能作为预防性疫苗的有效平台，而铁蛋白+CpG可能在需要强Th1反应的治疗应用中具有更大的潜力，例如慢性乙型肝炎（CHB）。

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引用次数: 0

One-dimensional ferromagnetism revealed by Kondo effect and linear V/W-shaped anisotropic magnetoresistance 近藤效应揭示的一维铁磁性和线性V/ w型各向异性磁阻

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-10-01 DOI: 10.1016/j.nantod.2025.102908

Zheng Wei , Yu-Hao Wan , Wenxiang Wang , Jiawang You , Zhisheng Peng , Julienne Impundu , Tao He , Changzhi Gu , Hongxuan Ren , Yong Jun Li , Qing-Feng Sun , Lianfeng Sun

Magnetic anisotropy can remove Mermin-Wagner prohibitions for magnetic order in two-dimensional materials. An interesting and fundamental question is to explore magnetism in materials/structures with still lower dimensions. Here we show that there is one-dimensional ferromagnetism along the edges between a molybdenum (Mo) strip and a monolayer graphene (MLG). When a Mo strip is deposited across an MLG with magnetron sputtering, the MLG underneath Mo is removed due to a solid-solid reaction, making two newly-formed, one-dimensional edges between the Mo strip and the MLG. For one Mo strip on an MLG, Kondo effect and anisotropic magnetoresistance (AMR) can be observed, which exhibits a unique linear V/W-shape in small magnetic fields. For two parallel Mo strips on a single MLG, besides Kondo effect and AMR, spin Hall effect (SHE) and inverse spin Hall effect (ISHE) have been observed at temperature up to 300 K, which implies the antiferromagnetic coupling between the edges. These results indicate the coexistence of Kondo effect and one-dimensional ferromagnetism and great potential applications.

磁各向异性可以消除二维材料中磁序的Mermin-Wagner禁令。一个有趣而基本的问题是探索低维材料/结构中的磁性。在这里，我们展示了沿钼（Mo）带和单层石墨烯（MLG）之间的边缘存在一维铁磁性。当磁控溅射沉积Mo条在MLG上时，由于固-固反应，Mo下面的MLG被移除，在Mo条和MLG之间形成两个新形成的一维边缘。对于MLG上的Mo条带，可以观察到近藤效应和各向异性磁电阻（AMR），在小磁场下呈现出独特的线性V/ w形状。在300 K温度下，对单根MLG上的两条平行Mo条，除了近田效应和AMR外，还观察到自旋霍尔效应（SHE）和逆自旋霍尔效应（ISHE），这表明边缘之间存在反铁磁耦合。这些结果表明近藤效应与一维铁磁性共存，具有广阔的应用前景。

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引用次数: 0

Revolutionizing role of magnetic field-guided MnFe2O4@ZIF-8@retinoic acid in DUCA conduits for inflammation inhibition and peripheral nerve regeneration 革命性的作用磁场引导MnFe2O4@ZIF-8@维甲酸在DUCA导管炎症抑制和周围神经再生

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-09-30 DOI: 10.1016/j.nantod.2025.102910

Majid Sharifi , Majid Salehi , Somayeh Ebrahimi-Barough , Mohammad Kamalabadi-Farahani

Neuroma formation following the repair of nerve injuries exceeding 0.9 cm in length severely impedes functional recovery. To overcome this challenge, we engineered magnetically responsive core-shell nanoparticles (MnFe₂O₄@ZIF-8@Retinoic acid, MFZR; 90–360 nm) to guide regeneration within a decellularized umbilical cord artery (DUCA) conduit. We investigated the synergistic effect of MFZR under an external magnetic field (MF) on Schwann cell behavior in vitro and on sciatic nerve repair in a rat model. Under MF exposure, MFZR significantly enhanced Schwann cell migration, alignment, and elongation on DUCA conduits. In-vivo, the MFZR+MF combination potently promoted functional recovery, as measured by the sciatic functional index, muscle compound action potential, and nerve conduction velocity, without inducing DUCA-related inflammation. Histological analysis demonstrated robust regeneration, characterized by increased axon diameter, an improved G-ratio, and elevated expression of S100 and NF-200. This regeneration was facilitated by a healing-promoting M2 macrophage polarization at the injury site. Critically, the strategy exhibited no systemic toxicity. These findings establish that magnetically guided MFZR effectively prevents neuroma in the DUCA conduits, orchestrates a pro-regenerative microenvironment, and achieves significant functional recovery, offering a promising translatable strategy for nerve repair.

长度超过0.9 cm的神经损伤修复后形成的神经瘤严重阻碍功能恢复。为了克服这一挑战，我们设计了磁响应核壳纳米颗粒（MnFe2O4@ZIF-8@维甲酸，MFZR; 90-360 nm）来引导去细胞脐带动脉（DUCA）导管内的再生。我们研究了外磁场作用下MFZR对体外雪旺细胞行为和大鼠坐骨神经修复的协同作用。在中频暴露下，MFZR显著增强了DUCA导管上雪旺细胞的迁移、排列和伸长。在体内，通过坐骨功能指数、肌肉复合动作电位和神经传导速度测量，MFZR+MF联合有效促进功能恢复，而不会引起duca相关炎症。组织学分析显示再生强劲，其特征是轴突直径增加，g比改善，S100和NF-200表达升高。损伤部位促进愈合的M2巨噬细胞极化促进了这种再生。关键的是，该策略没有表现出系统性毒性。这些发现表明，磁引导MFZR有效地预防了DUCA导管中的神经瘤，协调了一个促进再生的微环境，并实现了显著的功能恢复，为神经修复提供了一种有前途的可翻译策略。

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引用次数: 0

Non-invasive CRISPR/Cas9 nanocapsules specifically edit α-synuclein for effective Parkinson’s disease treatment 非侵入性CRISPR/Cas9纳米胶囊特异性编辑α-突触核蛋白，有效治疗帕金森病

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-09-30 DOI: 10.1016/j.nantod.2025.102903

Qingshan Yang , Yujing Sang , Nan Geng , Yang Liu , Dongya Zhang , Yan Zou , Meng Zheng

Parkinson’s disease (PD) is the most common movement disorders, affecting more than 1 % of the elderly population aged over 60 years old. Targeting the accumulation of the toxic protein α-synuclein (α-Syn) (SNCA) is a common therapeutic strategy for PD. CRISPR/Cas9 gene technology could provide an avenue to achieve reduced levels of this protein. However, the lack of effective and safe brain delivery vectors greatly hampers its applications for brain disorders. In this paper, we developed glucose directed single-particle nanocapsules that efficiently delivers CRISPR/Cas9 into targeted brain lesions to specifically edit the SNCA gene. Our CRISPR/Cas9 nanocapsules have a small size of 32 nm and formed with a polymeric shell which protects Cas9/sgRNA from enzymatic degradation. Benefitting from surface glucose decoration, our nanocapsules exhibited blood brain barrier (BBB) permeability and accumulation in brain lesions after intravenous administration. Additionally, CRISPR/Cas9 nanocapsules selectively reduced expression of the SNCA leading to down regulation of α-Syn protein, M1/M2 microglial re-polarization, amelioration of neuroinflammation and recovery of tryptophan hydroxylase (TH) in A53T transgenic mice. Importantly, CRISPR/Cas9 nanocapsules significantly improved performance of mice in a variety behavioral test with negligible side effects. Therefore, the CRISPR/Cas9 nanocapsules provides a versatile but potent platform for genetic engineering in brain disorders, especially genome mutations relevant to neuronal disease.

帕金森病（PD）是最常见的运动障碍，影响超过1 %的60岁以上老年人口。靶向毒性蛋白α-突触核蛋白（α-Syn）（SNCA）的积累是PD的常用治疗策略。CRISPR/Cas9基因技术可以提供降低这种蛋白水平的途径。然而，缺乏有效和安全的脑传递载体，极大地阻碍了其在脑疾病中的应用。在本文中，我们开发了葡萄糖定向单颗粒纳米胶囊，可以有效地将CRISPR/Cas9递送到靶向脑病变中，特异性编辑SNCA基因。我们的CRISPR/Cas9纳米胶囊具有32 nm的小尺寸，由聚合物外壳形成，可以保护Cas9/sgRNA免受酶促降解。得益于表面葡萄糖修饰，我们的纳米胶囊在静脉给药后表现出血脑屏障（BBB）的渗透性和脑病变的积聚。此外，CRISPR/Cas9纳米胶囊选择性地降低SNCA的表达，导致A53T转基因小鼠α-Syn蛋白下调、M1/M2小胶质细胞再极化、神经炎症改善和色氨酸羟化酶（TH）恢复。重要的是，CRISPR/Cas9纳米胶囊显著提高了小鼠在各种行为测试中的表现，副作用可以忽略不计。因此，CRISPR/Cas9纳米胶囊为大脑疾病，特别是与神经元疾病相关的基因组突变的基因工程提供了一个多功能但有效的平台。

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引用次数: 0

Stimuli-responsive halloysite colloidosomes for active delivery of antiviral agents in plant protection 刺激反应性高岭土胶体体在植物保护中抗病毒药物的主动递送

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-09-29 DOI: 10.1016/j.nantod.2025.102904

Avital Ella Ben-Haim , Reut Amar Feldbaum , Uri Perry , Antolin Jesila Jesu Amalraj , Karthik Ananth Mani , Einat Zelinger , Einat Native-Roth , Mohamed Samara , Aviv Dombrovsky , Guy Mechrez

This study introduces a novel root protection method against Tobamovirus, using thermally responsive water-in-oil colloidosomes stabilized by halloysite nanotubes (HNTs). These colloidosomes are formed in situ through a cost-effective process using HNTs, canola oil, water, and two trietoxysilanes: (3-aminopropyl)trietoxysilanes (APTES) and Dodecyltriethoxysilane (DTES). The combination of hydrophilic APTES and hydrophobic DTES allows precise control over emulsion type and enables the formation of stable colloidosomes. A key feature of this system is the solar-triggered release of chlorinated trisodium phosphate (Cl-TSP), an antiviral agent that disinfects the root area and inactivates viral particles. The amount and timing of Cl-TSP release were measured, demonstrating controlled and localized delivery. The formulation provided high protection in tomato plants, while remaining biofriendly and environmentally safe. This work offers a smart-release platform for effective and sustainable crop protection.

本研究介绍了一种利用高岭土纳米管（HNTs）稳定的热响应性油包水胶体体保护根抗托巴莫病毒的新方法。这些胶体体是通过使用HNTs、菜籽油、水和两种三乙基氧基硅烷（3-氨基丙基）三乙基氧基硅烷（APTES）和十二烷基三乙基氧基硅烷（DTES）的经济有效的工艺在原位形成的。亲水性APTES和疏水性DTES的结合可以精确控制乳液类型，并使形成稳定的胶体体。该系统的一个关键特点是太阳能触发的氯化磷酸三钠（Cl-TSP）的释放，这是一种抗病毒药物，可以消毒根部并灭活病毒颗粒。测定了Cl-TSP的释放量和释放时间，显示出控制和局部释放。该配方在番茄植株中提供了高保护，同时保持生物友好和环境安全。这项工作为有效和可持续的作物保护提供了一个智能释放平台。

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引用次数: 0