Nano Today最新文献_第3页

Pure organic phosphorescent scintillator for glucose metabolism regulation-enhanced low-dose X-ray-induced photodynamic therapy 用于葡萄糖代谢调节增强型低剂量 X 射线诱导光动力疗法的纯有机磷光闪烁体

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-13 DOI: 10.1016/j.nantod.2024.102548

Xiaoyu Zhang , Yating Wen , Baojie Du , Yating Huang , Yunxiang Liu , Rong Zhang , Liping Li , Ruiping Zhang

X-ray-induced photodynamic therapy (X-PDT) leverages the penetration power of X-rays to generate reactive oxygen species (ROS) within deep tissues for cancer treatment, merging the benefits of both photodynamic therapy and radiotherapy. Traditional X-PDT, however, typically relies on inorganic scintillators containing heavy-metals to act as energy transducers, exciting nearby photosensitizers to produce singlet oxygen. Moreover, the hypoxia conditions prevalent in tumors can severely diminish the efficacy of X-PDT. Here, we report a metal-free, self-enhanced organic phosphorescent nanoscintillator (termed OPSG NPs) capable of efficiently generating singlet oxygen under low-dose X-ray irradiation, facilitated by glucose metabolism regulation. OPSG NPs are constructed through a self-assembly behavior driven by molecular interactions between an organic phosphorescent scintillator and a glucose transporter 1 (GLUT1) inhibitor. The OPSG NPs serve dual functions, acting as both scintillator and photosensitizer, which can be activated by direct X-ray irradiation. Additionally, they possess the ability to inhibit glucose supply and reduce oxygen consumption for tumor cell respiration. This strategy effectively alleviates the hypoxia within the tumor microenvironment and consequently enhances the therapeutic efficacy of X-PDT. Both in vitro and in vivo studies demonstrate the excellent antitumor X-PDT performance. This glucose metabolism regulation-enhanced low-dose X-PDT strategy paves the way for more efficient therapy against deep-seated tumors.

X 射线诱导的光动力疗法（X-PDT）利用 X 射线的穿透力在深层组织内产生活性氧（ROS）来治疗癌症，融合了光动力疗法和放射疗法的优点。然而，传统的 X-PDT 通常依赖含有重金属的无机闪烁体作为能量转换器，激发附近的光敏剂产生单线态氧。此外，肿瘤中普遍存在的缺氧条件会严重削弱 X-PDT 的功效。在此，我们报告了一种无金属、自增强的有机磷光纳米闪烁体（称为 OPSG NPs），它能在低剂量 X 射线照射下有效地产生单线态氧，并能通过葡萄糖代谢调节发挥作用。OPSG NPs 是通过有机磷光闪烁体和葡萄糖转运体 1（GLUT1）抑制剂之间的分子相互作用驱动的自组装行为构建的。OPSG NPs 具有双重功能，既是闪烁体又是光敏剂，可通过直接 X 射线照射激活。此外，它们还具有抑制葡萄糖供应和减少肿瘤细胞呼吸耗氧量的能力。这种策略能有效缓解肿瘤微环境中的缺氧状况，从而提高 X-PDT 的疗效。体外和体内研究都证明了 X-PDT 卓越的抗肿瘤性能。这种葡萄糖代谢调节增强型低剂量 X-PDT 策略为更有效地治疗深部肿瘤铺平了道路。

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引用次数: 0

Encapsulated solid-liquid dual continuous pathways with low modulus and high thermal conductivity for dynamic target autonomous thermal management 具有低模量和高导热性的封装固液双连续通路，用于动态目标自主热管理

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-11 DOI: 10.1016/j.nantod.2024.102549

Qingxia He, Mengmeng Qin, Heng Zhang, Shuo Wang, Wei Feng

Materials that exhibit both high thermal conductivity and soft elasticity are essential for effective thermal management in complex dynamic environments. Additionally, these materials can serve as sensing layers to interact with external conditions. However, materials that possess high thermal conductivity often have a high modulus, which limits their soft elasticity. In this study, we introduce a novel solid-liquid dual-oriented pathway embedded in modified PDMS. This design incorporates continuous liquid metal pathways and vertically aligned graphene, allowing for the optimal utilization of their high thermal conductivity, low modulus, and excellent resilience. The resulting LM-VGA/mPDMS composites exhibit impressive thermal conductivity (κ_⊥ = 7.32 Wm^–1K⁻¹) alongside soft elasticity and a remarkably low elastic modulus of 71.14 kPa. The LM-VGA/mPDMS composite facilitates effective thermal management in both dynamic and static conditions. Furthermore, the LM-VGA/mPDMS composites function as non-contact, self-powered sensors capable of accurately detecting object positions and states, making them suitable for dynamic target autonomous thermal management.

同时具有高导热性和软弹性的材料对于在复杂的动态环境中进行有效的热管理至关重要。此外，这些材料还可用作传感层，与外部条件相互作用。然而，具有高热导率的材料通常具有较高的模量，这限制了它们的软弹性。在本研究中，我们介绍了一种嵌入改性 PDMS 的新型固液双向通路。这种设计结合了连续的液态金属通路和垂直排列的石墨烯，使它们的高热导率、低模量和出色的弹性得到了最佳利用。由此产生的 LM-VGA/mPDMS 复合材料不仅具有令人印象深刻的热导率（κ⊥ = 7.32 Wm-1K-1），还具有柔软的弹性和 71.14 kPa 的超低弹性模量。LM-VGA/mPDMS 复合材料有助于在动态和静态条件下进行有效的热管理。此外，LM-VGA/mPDMS 复合材料还具有非接触、自供电传感器的功能，能够准确检测物体的位置和状态，因此适用于动态目标自主热管理。

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引用次数: 0

In Vivo MRI tracking of bone mesenchymal stem cell viability with a T1-T2 switchable contrast agent 利用 T1-T2 可切换造影剂进行体内磁共振成像追踪骨间充质干细胞的存活率

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-11 DOI: 10.1016/j.nantod.2024.102551

Jincong Yan , Zhongzhong Lu , Mingsheng Xu , Jihuan Liu , Ye Zhang , Yi Cao , Renjun Pei

The successful implementation of stem cell therapy requires the development of imaging techniques to track transplanted stem cells in vivo and monitor their fate over time. Most in vivo imaging methods focus on providing information about the distribution and migration of transplanted stem cells, while monitoring their viability-crucial for optimizing therapy-remains undeveloped. Although a few in vivo imaging techniques have been developed for assessing the viability of transplanted stem cells, their applicability is restricted by limited penetration depth. To address this, magnetic resonance imaging (MRI) that is collaboratively utilized with tailored contrast agents has been explored to track the viability of transplanted stem cells without this limitation. However, currently available MRI contrast agents struggle with low accuracy in monitoring viability due to poor controllability or minimal signal change in response to cell death. Here, we present an extremely small iron oxide nanoparticles (ESIONPs)-based T₁-T₂ switchable MRI contrast agent (ESIONPs-GSH) designed to accurately detect cell apoptosis in response to elevated reactive oxygen species (ROS).Specifically, ESIONPs-GSH was obtained by modifying the surface of ESIONPs with ROS-sensitive glutathione (GSH) and amphipathic 3-((3-aminopropyl) dimethylammonio) propane-1-sulfonate (ADPS) molecules. The results demonstrate that ESIONPs-GSH is biocompatible, with negligible effects on the proliferation and differentiation of bone mesenchymal stem cells (BMSCs) post-labeling. Additionally, BMSCs labeled with ESIONPs-GSH exhibit T₁ contrast; upon cell death, increasing cellular ROS oxidize GSH and induce cross-linking of ESIONPs-GSH, resulting in a switch to T₂ contrast. Benefiting from the significantly contrasting signal following the T₁-T₂ contrast switch, ESIONPs-GSH allows for accurate assessment of the survival of BMSCs transplanted into the axillary regions of mice through MRI monitoring. ESIONPs-GSH enabled MRI can effectively track transplanted stem cell viability in vivo without penetration depth limitations, making it a promising tool for guiding stem cell-based therapies.

干细胞疗法的成功实施需要开发成像技术，以追踪体内移植的干细胞，并随着时间的推移监测其命运。大多数体内成像方法侧重于提供有关移植干细胞分布和迁移的信息，而监测其存活率--对优化治疗至关重要--仍未得到开发。虽然目前已开发出一些用于评估移植干细胞存活能力的体内成像技术，但由于穿透深度有限，其适用性受到限制。为了解决这个问题，人们探索了磁共振成像（MRI）技术，该技术与定制的造影剂配合使用，可跟踪移植干细胞的存活率，而不受这种限制。然而，由于可控性差或细胞死亡时信号变化极小，目前可用的磁共振成像造影剂在监测存活率方面的准确性很低。具体来说，ESIONPs-GSH是通过在ESIONPs表面修饰对ROS敏感的谷胱甘肽（GSH）和两性离子3-((3-aminopropyl) dimethylammonio) propane-1-sulfonate（ADPS）分子而获得的。研究结果表明，ESIONPs-GSH 具有生物相容性，标记后对骨间充质干细胞（BMSCs）的增殖和分化影响微乎其微。此外，用 ESIONPs-GSH 标记的 BMSCs 显示出 T1 对比度；当细胞死亡时，增加的细胞 ROS 会氧化 GSH 并诱导 ESIONPs-GSH 交联，从而转为 T2 对比度。ESIONPs-GSH 在 T1-T2 对比度转换后会产生明显的对比度信号，因此可以通过核磁共振成像监测准确评估移植到小鼠腋窝部位的 BMSCs 的存活情况。ESIONPs-GSH支持的核磁共振成像可有效追踪移植干细胞在体内的存活情况，而不受穿透深度的限制，使其成为指导干细胞疗法的一种有前途的工具。

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引用次数: 0

MXene - A frontier exploiter in carbon dioxide conversion: Synthesis and adsorption MXene--二氧化碳转化的前沿技术：合成与吸附

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-08 DOI: 10.1016/j.nantod.2024.102546

Ting Yan , L.C. Xu , W.G. Pan , L.W. Wang

MXene, as a novel two-dimensional material, has garnered global attention due to its unique structure and outstanding physicochemical properties. MXene-based adsorption/catalytic agents, characterized by their high specific surface area, abundant surface functional groups, excellent conductivity, and tunability, are considered excellent materials for carbon dioxide (CO₂) adsorption and conversion. In recent years, the synthesis methods of MXene have evolved from the initial hydrofluoric acid (HF) etching to Lewis acid molten salt etching, significantly reducing the risks and pollution associated with the synthesis process while enhancing yield and performance. This review provides a comprehensive overview of the application of MXene materials in the adsorption and catalytic conversion of CO₂. It first outlines the development history of MXene. Subsequently, the synthesis methods of MXene are discussed, with particular emphasis on the advantages of fluorine-free synthesis methods, including relatively mild etching conditions, safety, pollution-free nature, and ease of control. Later, we elucidate its progress in CO₂ adsorption and conversion. Finally, the prospects of MXene materials in the field of CO₂ conversion are discussed, along with an exploration of the strengths and weaknesses of current synthesis methods. It has pointed out that MXene holds significant potential in constructing a sustainable carbon cycle economy, underscoring its crucial role in sustainable development.

MXene 作为一种新型二维材料，因其独特的结构和出色的物理化学特性而备受全球关注。基于 MXene 的吸附/催化剂具有高比表面积、丰富的表面官能团、优异的导电性和可调性等特点，被认为是二氧化碳（CO2）吸附和转化的绝佳材料。近年来，MXene 的合成方法已从最初的氢氟酸（HF）蚀刻发展到路易斯酸熔盐蚀刻，大大降低了合成过程中的风险和污染，同时提高了产量和性能。本综述全面概述了 MXene 材料在二氧化碳吸附和催化转化中的应用。首先概述了 MXene 的发展历史。随后，讨论了 MXene 的合成方法，特别强调了无氟合成方法的优势，包括蚀刻条件相对温和、安全、无污染和易于控制。随后，我们阐释了其在二氧化碳吸附和转化方面的进展。最后，讨论了 MXene 材料在二氧化碳转化领域的前景，并探讨了当前合成方法的优缺点。报告指出，MXene 在构建可持续碳循环经济方面具有巨大潜力，强调了其在可持续发展中的关键作用。

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引用次数: 0

Emerging intelligent wearable devices for cardiovascular health monitoring 用于心血管健康监测的新兴智能可穿戴设备

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-08 DOI: 10.1016/j.nantod.2024.102544

Yiqian Wang , Yang Zou , Zhou Li

Cardiovascular diseases have long posed a significant threat to human health. Wearable devices are increasingly vital in cardiovascular health monitoring, disease screening, and early warning because of their non-invasiveness, real-time data provision and continuous monitoring capability. The collection, processing, and analysis of data in cardiovascular health monitoring involve numerous repetitive and standardized tasks, where artificial intelligence (AI) technology plays a pivotal role. AI is particularly effective in handling large volumes of data, thus enhancing the diagnostic and predictive capabilities of wearable devices. This review summarizes essential indicators for assessing cardiovascular health and provides a comprehensive introduction to commonly used non-invasive monitoring methods, including pulse pressure, photoplethysmography, electrocardiogram, bioimpedance analysis, seismocardiography/ ballistocardiography, and ultrasonography. Additionally, some impressive advances in wearable cardiovascular health monitoring technologies are reviewed and their integration with AI is highlighted, demonstrating typical application cases from recent years. Finally, the review discusses the current challenges of integrating AI into wearable devices for cardiovascular health monitoring, focusing on aspects from device design, algorithm optimization, comfort, reliability, and security. With the seamless integration of AI and wearable devices, a new generation of wearable intelligent devices promises to revolutionize the monitoring, prevention and management strategies of cardiovascular diseases.

长期以来，心血管疾病一直对人类健康构成重大威胁。可穿戴设备因其非侵入性、实时数据提供和持续监测能力，在心血管健康监测、疾病筛查和早期预警方面发挥着越来越重要的作用。心血管健康监测中的数据收集、处理和分析涉及大量重复性和标准化的任务，人工智能（AI）技术在其中发挥着举足轻重的作用。人工智能在处理大量数据方面尤为有效，从而提高了可穿戴设备的诊断和预测能力。本综述总结了评估心血管健康的基本指标，并全面介绍了常用的无创监测方法，包括脉压、光电血压计、心电图、生物阻抗分析、地震心动图/弹道心动图和超声波检查。此外，还回顾了可穿戴心血管健康监测技术的一些令人印象深刻的进展，并重点介绍了这些技术与人工智能的结合，展示了近年来的典型应用案例。最后，综述讨论了当前将人工智能集成到心血管健康监测可穿戴设备中的挑战，重点关注设备设计、算法优化、舒适性、可靠性和安全性等方面。随着人工智能与可穿戴设备的无缝整合，新一代可穿戴智能设备有望彻底改变心血管疾病的监测、预防和管理策略。

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引用次数: 0

Biomechanically matched and multistage hybrid porous scaffolds for stem cell-based osteochondral regeneration 用于干细胞骨软骨再生的生物力学匹配多级混合多孔支架

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-04 DOI: 10.1016/j.nantod.2024.102539

Shao-Jie Wang , Rong-Hui Deng , Chang-Hui Song , Fu-Zhen Yuan , Peng-Qiang Li , Xiao-Yan Cao , Xing Wang , Lin Lin , Ji-Ying Zhang , Yu-Fang Zhu , Jia-Kuo Yu

Osteochondral tissue has limited self-repair ability owing to its ischemic microenvironment and mechanically challenging conditions. Cell-based tissue engineering, a promising strategy for osteochondral regeneration, is influenced by the osteochondral-inducing scaffolds, such as bioactive agents and bionic microstructures, and mechanical properties. The current platforms are unsatisfactory because they fail to match the mechanical strength of natural osteochondral tissue while retaining high porosity and bioactivity. Hence, we developed growth factor-free multistage porous hybrid scaffolds composed of poly(lactic-co-glycolic acid) (PLGA) backbones with milli-micrometer two-stage pores and bioactive poly(γ-ethyl-l-glutamate) (PELG) thermo-responsive hydrogel. Highly porous pure PLGA backbones with controllable pore structures and tunable mechanical strength were prepared using low-temperature deposition modeling 3D printing and salt-leaching method with sodium chloride (NaCl) as a porogen. The arginine-glycine-aspartic acid (RGD) peptide and the chondrogenic molecule kartogenin (KGN) were conjugated to the terminals of poly(ethylene glycol) and PELG to enhance cell proliferation and induce cartilage differentiation, respectively. Moreover, the multistage PLGA/^RGDPELG_KGN porous hybrid scaffolds provided conducive environments for the proliferation and chondrogenesis of peripheral blood-derived mesenchymal stem cells (PBMSCs) and successfully repaired critical-sized osteochondral defects in the rabbit femoral trochlea, indicating its clinical potential for osteochondral repair.

骨软骨组织由于其缺血微环境和具有机械挑战性的条件，自我修复能力有限。基于细胞的组织工程是一种很有前景的骨软骨再生策略，它受到骨软骨诱导支架（如生物活性剂和仿生微结构）和机械性能的影响。目前的平台不能令人满意，因为它们无法在保持高孔隙率和生物活性的同时，达到天然骨软骨组织的机械强度。因此，我们开发了不含生长因子的多级多孔混合支架，由具有毫微米级两级孔隙的聚乳酸-共聚乙醇酸（PLGA）骨架和生物活性聚γ-乙基-谷氨酸（PELG）热响应水凝胶组成。以氯化钠（NaCl）为成孔剂，采用低温沉积建模三维打印和盐浸法制备了具有可控孔隙结构和可调机械强度的高多孔纯聚乳酸乙二胺（PLGA）骨架。精氨酸-甘氨酸-天冬氨酸（RGD）肽和软骨生成分子卡托原蛋白（KGN）分别被连接到聚乙二醇和PELG的末端，以增强细胞增殖和诱导软骨分化。此外，多级PLGA/RGDPELGKGN多孔杂化支架为外周血间充质干细胞（PBMSCs）的增殖和软骨生成提供了有利的环境，并成功修复了家兔股骨蹄部临界大小的骨软骨缺损，显示了其在骨软骨修复方面的临床潜力。

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引用次数: 0

Enhanced glomerular transfection by BMP7 gene nanocarriers inhibits CKD and promotes SOX9-dependent tubule regeneration 通过 BMP7 基因纳米载体增强肾小球转染可抑制 CKD 并促进 SOX9 依赖性肾小管再生

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-04 DOI: 10.1016/j.nantod.2024.102545

Yifan Tai , Zhen Liu , Yanrong Wang , Xinyan Zhang , Ruifang Li , Jiangyue Yu , Yao Chen , Lili Zhao , Jia Li , Xueyuan Bai , Deling Kong , Adam C. Midgley

Renal fibrosis and loss of kidney function are key characteristics of chronic kidney disease (CKD). To address the lack of effective treatments, multifunctional layer-by-layer (LbL) assembled polymeric gene-carrier nanoparticles (PCHS-NP) are prepared to realize preferential accumulation and retention within renal glomerular cells, thereby effectively leveraging cortically localized structures for the synthesis and paracrine secretion of the antifibrotic growth factor, bone morphogenetic protein-7 (BMP7). PCHS-NP had stable homogenous morphologies, kidney-targeting functionality, antioxidative effects, and high transfection efficiency. In unilateral ureteral obstruction (UUO)-induced renal fibrosis, a single systemic injection of PCHS-NP prevents tubular atrophy and interstitial fibrosis, and the resultant tissue microenvironment is more conducive to tubular regeneration driven by the upregulation of proliferative SOX9-expressing tubular cells. In longer-term folic acid (FA)-induced renal fibrosis, we show that early, late, and repeat systemic injections restore kidney health and function. This study indicates that PCHS-NP accomplish a promising therapeutic option for the treatment of CKD.

肾脏纤维化和肾功能丧失是慢性肾脏病（CKD）的主要特征。为了解决缺乏有效治疗方法的问题，研究人员制备了多功能逐层（LbL）组装聚合物基因载体纳米颗粒（PCHS-NP），以实现在肾小球细胞内的优先积聚和保留，从而有效利用皮质局部结构合成和旁分泌抗纤维化生长因子骨形态发生蛋白-7（BMP7）。PCHS-NP 具有稳定的均质形态、肾脏靶向功能、抗氧化作用和高转染效率。在单侧输尿管梗阻（UUO）诱导的肾脏纤维化中，单次全身注射PCHS-NP可防止肾小管萎缩和间质纤维化，由此产生的组织微环境更有利于表达SOX9的增殖性肾小管细胞上调所驱动的肾小管再生。在长期叶酸（FA）诱导的肾脏纤维化中，我们发现早期、晚期和重复全身注射叶酸都能恢复肾脏的健康和功能。这项研究表明，PCHS-NP是治疗慢性肾功能衰竭的一种很有前景的治疗方案。

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引用次数: 0

Dynamics of strong metal-support interactions: Investigating Pt and Pt-based alloys on CdS nanorods through experimental and simulated approaches 强金属-支撑相互作用的动力学：通过实验和模拟方法研究 CdS 纳米棒上的铂和铂基合金

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-11-02 DOI: 10.1016/j.nantod.2024.102543

Jiuyi Hu , Jiayu Xu , Ri Feng , Shaohui Zheng , Jiajia Li , Zhicheng Zhang , Wenjing Liu , Faisal Saleem

The catalytic performance of supported metal nanoparticles (NPs) is greatly affected by metal-support interaction (MSI). Understanding the mechanisms and dynamics of MSI in heterogeneous catalysis remains challenging. Traditionally, MSI studies have focused on metal oxide supports and rarely compared MSI between Pt and Pt-based alloys, despite the importance of Pt in catalysis. In this study, we introduce CdS nanorods as a novel support material and investigate the MSI behavior of both Pt and Pt-based alloy NPs using in situ TEM electron beam irradiation. Our findings show that Pt NPs have strong MSI with CdS and that encapsulation layers form over Pt NPs because Pt has the high surface energy. On the other hand, Pt-based alloys have weaker MSI. These experiments were validated by direct thermal annealing for four hours. Molecular dynamics simulations were used to explain the observed behavior, providing insights into how the surface energy differences between Pt and Pt-based alloys influence their interactions with CdS nanorods. These findings offer valuable insights into catalyst design, highlighting the potential for controlling MSI strength to optimize catalytic performance in heterogeneous systems.

金属-支撑物相互作用（MSI）对支撑金属纳米粒子（NPs）的催化性能有很大影响。了解异相催化中 MSI 的机理和动态仍具有挑战性。尽管铂在催化过程中具有重要作用，但传统的 MSI 研究主要集中在金属氧化物支撑上，很少对铂和铂基合金之间的 MSI 进行比较。在本研究中，我们引入了 CdS 纳米棒作为新型支撑材料，并利用原位 TEM 电子束辐照研究了铂和铂基合金 NPs 的 MSI 行为。我们的研究结果表明，铂氮氧化物与 CdS 具有很强的 MSI，并且由于铂具有很高的表面能，在铂氮氧化物上形成了封装层。另一方面，铂基合金的 MSI 较弱。这些实验通过直接热退火四小时进行了验证。分子动力学模拟用于解释观察到的行为，为了解铂和铂基合金之间的表面能差异如何影响它们与 CdS 纳米棒的相互作用提供了见解。这些发现为催化剂设计提供了宝贵的见解，突出了控制 MSI 强度以优化异质体系催化性能的潜力。

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引用次数: 0

Glucose-gated nanocoating endowing polyetheretherketone implants for enzymatic gas therapy to boost infectious diabetic osseointegration 葡萄糖门控纳米涂层赋予聚醚醚酮植入物以酶气疗法，促进感染性糖尿病骨整合

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-10-31 DOI: 10.1016/j.nantod.2024.102541

Jiahe Li , Menglin Fan , Zheng Jiao , Yau Kei Chan , Lei Cheng , Jiyao Li , Yi Deng , Kunneng Liang

The hyperglycemic micromilieu surrounding implants in diabetic patients leads to high failure rate of implantation and implant-associated infection. Carbon monoxide (CO) has been reported to combat infections; however, its on-demand liberation and the elucidation of the underlying antibacterial mechanism remain challenging. To address this issue, we develop a multipurpose orthopedic implant comprising polyetheretherketone, glucose oxidase (GOx), and manganese carbonyl nanocrystals (MnCO), serving as a glucose-gated nanocoating for enzymatic gas therapy to improve infectious diabetic osseointegration. The GOx acts as a glucose-actuated gate responsive to hyperglycemia, thereby delivering CO in situ triggered by the GOx-driven Fenton-like reaction of MnCO nanocrystals. The released CO considerably prevents bacterial multiplication by penetrating the membrane, binding to cytochrome bo₃, and interfering with the respiratory chain in vitro. Furthermore, the engineered implant displays desired antibacterial properties and enhances osseointegration in vivo. Collectively, the orthopedic nanocoating implant is capable of delivering glucose-gated enzymatic gas therapy, promising for treating infectious diabetic bone defects.

糖尿病患者植入物周围的高血糖微环境导致植入失败率和植入物相关感染率居高不下。据报道，一氧化碳（CO）具有抗感染作用；然而，按需释放一氧化碳以及阐明其潜在的抗菌机制仍是一项挑战。为了解决这个问题，我们开发了一种由聚醚醚酮、葡萄糖氧化酶（GOx）和羰基锰纳米晶体（MnCO）组成的多用途骨科植入物，作为一种葡萄糖门控纳米涂层，用于酶促气体疗法，以改善糖尿病感染性骨结合。GOx 可作为葡萄糖触发门对高血糖做出反应，从而在 GOx 驱动的 MnCO 纳米晶体的芬顿反应触发下原位释放二氧化碳。释放出的 CO 可穿透薄膜，与细胞色素 bo3 结合，并在体外干扰呼吸链，从而大大阻止了细菌的繁殖。此外，这种工程植入物还具有理想的抗菌特性，并能增强体内的骨结合。总之，骨科纳米涂层植入物能够提供葡萄糖门控酶气体疗法，有望用于治疗感染性糖尿病骨缺损。

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引用次数: 0

Atomic scale in-situ observation of gas-solid interaction regulating the pre-nucleation process of Pd atomic clusters 原子尺度原位观测调节钯原子团簇预成核过程的气固相互作用

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2024-10-30 DOI: 10.1016/j.nantod.2024.102533

Yuchen Zhu, Yinghui Sun, Zhitao Zhao, Yingying Xu, Hao Li, Rongming Wang

Advancements in nanotechnology have propelled the understanding of atomic-scale nucleation processes, essential for the evolution of atomic manufacturing. The process of amorphous precursors nucleation showcases a complex transition influenced by various factors. Utilizing aberration-corrected ETEM and theoretical calculation, we explore the nucleation of amorphous Pd atomic clusters. This study examines the nucleation dynamics and gas-solid interaction regulating of Pd clusters on ultrathin carbon films, prepared via electron beam evaporation. HRTEM observation and FFT analysis reveal that, in the early stage of nucleation, Pd cluster growth predominantly follows an Ostwald ripening-like mechanism. Atoms from smaller clusters migrate and attach to larger ones, facilitating their progression to critical nucleation size. Environmental conditions significantly influence this process; hydrogen atmospheres lower the surface energy of Pd clusters, reducing the critical nucleation size, while argon atmospheres impede growth of Pd clusters by occupying migration sites on the carbon surface. These insights into atomic cluster behavior and environmental interactions are crucial for understanding the early stages of nucleation from amorphous to crystalline and can help opens new avenues for the controlled fabrication of materials with optimized functionalities.

纳米技术的进步推动了对原子尺度成核过程的了解，这对原子制造业的发展至关重要。非晶前驱体的成核过程展示了受各种因素影响的复杂转变。利用像差校正 ETEM 和理论计算，我们探索了非晶钯原子簇的成核过程。本研究探讨了电子束蒸发法制备的超薄碳膜上钯原子簇的成核动力学和气固相互作用调控。HRTEM 观察和 FFT 分析表明，在成核的早期阶段，钯簇的生长主要遵循类似奥斯特瓦尔德熟化的机制。较小簇团中的原子迁移并附着到较大的簇团上，促进它们向临界成核尺寸发展。环境条件会对这一过程产生重大影响；氢气环境会降低钯簇的表面能，从而减小临界成核尺寸，而氩气环境则会占据碳表面的迁移位点，从而阻碍钯簇的生长。这些关于原子团簇行为和环境相互作用的见解对于理解从无定形到晶体成核的早期阶段至关重要，有助于为控制制造具有优化功能的材料开辟新的途径。

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