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Antibacterial and Wound Healing Activity of 2% Formulation of 2-Medpy-3-CN on Infected Burn Wounded Animal Model 2% 2-Medpy-3-CN制剂对感染性烧伤动物模型的抗菌及创面愈合作用
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.2
Vasantha Kumari Neela, Nor Maziah Ahmad, Surajo Adamu Wada, Arun Kumar Karunanidhi
Introduction: Humans have learned to recognize and process plants into medicinal forms through centuries. Burns can spread to other tissues, especially when infected with bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSA). The study aimed to assess the in vivo antibacterial and wound healing activity of 2% formulation of 2-Medpy-3-CN on infected burn wounded animal model. Methods: In vitro antibacterial activity of the Alsti was done by broth dilution and disc diffusion methods. Alsti 2% ointment was prepared for the infected burn wound treatment. A total of 18 rats are grouped into A, B, C, and D, the first three groups (A-C) were injured thermally, and Group D was used as healthy controls. The three test Groups were exposed to MRSA ATCC 43300 at 105 CFU/mL. Group A was treated with 2% Alsti, Group B with Silver sulfadiazine 1% (SSD), and Group C was untreated. Wounds healing was assessed by the healed area and microscopic identification of hematoxylin and eosin (H&E)-stained skin tissue. Results: Wound healing progresses with application of Alsti 2% ointment as observed through wound diameter and histopathological changes of the skin. Wound diameter decreases with treatments, while the contrary was observed in the non-treated group. Microscopic observation of the stained skin showed that epidermal development, and collagen formation progress with treatment days. Untreated wounds showed marked inflammation, progressive ulceration, and necrosis. Conclusion: Alsti 2% formulation showed antibacterial and wound healing activities, hence, can be used as alternative in burn wound infections.
几个世纪以来,人类已经学会了识别并将植物加工成药物。烧伤可以扩散到其他组织,特别是当感染了耐甲氧西林金黄色葡萄球菌(MRSA)等细菌时。本研究旨在评价2% 2-Medpy-3-CN制剂对感染性烧伤模型动物的体内抗菌和创面愈合活性。方法:采用肉汤稀释法和盘片扩散法测定其体外抑菌活性。制备2% Alsti软膏用于感染性烧伤创面的治疗。将18只大鼠分为A、B、C、D四组,前三组(A-C组)热损伤,D组为健康对照组。三个实验组均以105 CFU/mL的剂量暴露于MRSA ATCC 43300。A组2% Alsti治疗,B组1%磺胺嘧啶银(SSD)治疗,C组不治疗。通过苏木精和伊红(H&E)染色皮肤组织的愈合面积和显微鉴定来评估伤口愈合情况。结果:应用2% Alsti软膏后,创面愈合进展,通过创面直径及皮肤组织病理学变化观察。伤口直径随治疗而减小,而未治疗组则相反。显微镜下观察染色皮肤的表皮发育,胶原蛋白的形成随着治疗时间的推移而进展。未治疗的伤口表现出明显的炎症、进行性溃疡和坏死。结论:2% Alsti制剂具有抗菌和创面愈合作用,可作为烧伤创面感染的替代剂型。
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引用次数: 0
Relationship of Physical Environmental Conditions of Houses with the Incidence of Pneumonia among Children under Five 房屋物理环境条件与5岁以下儿童肺炎发病率的关系
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.28
T. R. Sinaga, S. Purba, Jek Amidos Pardede, I. E. Purba, Henny Syapitri, Sandeep Poddar
Introduction: In 2019, according to the World Health Organization (WHO), pneumonia is the leading infectious cause of death in children under the age of five. In 2017, pneumonia killed 808,694 children under five, accounting for 15% of all fatalities among children under the age of five. Methods: An observational analytic survey with a case control design was used as the study approach. The research samples were collected using a simple random sampling procedure with 48 children under the age of five separated into two groups, 24 samples for the case group and 24 samples for the control group. The research was carried out between February and July of 2020. This study tools used were observation sheets and rollmeters.The data was analyzed using univariate and bivariate analysis using the Chi-Square test at a significance level of 0.05. Results: The results showed that there was a relationship between incidence of pneumonia in children under five with different variables, respectively, ventilation area, floor type, wall type, presence of smoke hole. Conclusion: It implies that the community should pay attention to the overall condition of the house, one of which is by improving home ventilation, adjusting the room area to the number of occupants, quitting smoking in the house, and cleaning the floor more often.
简介:根据世界卫生组织(世界卫生组织)的数据,2019年,肺炎是五岁以下儿童的主要传染病死亡原因。2017年,肺炎导致808694名五岁以下儿童死亡,占五岁以下所有死亡人数的15%。方法:采用病例对照设计的观察性分析调查作为研究方法。研究样本采用简单的随机抽样程序收集,48名5岁以下儿童分为两组,病例组24份,对照组24份。这项研究于2020年2月至7月进行。这项研究使用的工具是观察表和测辊仪。使用卡方检验对数据进行单变量和双变量分析,显著性水平为0.05。结果:5岁以下儿童的肺炎发病率与通风面积、地板类型、墙壁类型、是否有烟孔等不同变量存在相关性。结论:这意味着社区应该关注房子的整体状况,其中之一是改善家庭通风,根据居住人数调整房间面积,戒烟,并经常清洁地板。
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引用次数: 0
Amelogenesis Imperfecta Restorations Survival Rate: A Retrospective Study Amegenesis不全修复生存率的回顾性研究
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.31
A. Zagdwon, Anas Omar, M. Kowash
Introduction: Amelogenesis imperfecta (AI) is a rare genetic disease affecting both dentitions. Factors such as age, socioeconomic status, dentition and AI type and severity should be taken into consideration in treatment planning. Aim: This retrospective study aimed to assess the survival rate of AI main restorative options and the effects of gender and dentition type. Methods: The study sample comprised 28 dental records of patients aged 5-17 years affected by AI (15 females, 13 males) and with anterior and/or posterior restoration in primary and/or permanent tooth/teeth. The fate of each restoration was classified into three categories: failed, withdrawn and censored and analyzed by the life table method of survival analysis. Results: Out of 233 restorations performed, the most frequently used restoration was preformed metal crowns (PMCs), followed by anterior composite, posterior composite, adhesive casting, Ketac fill and amalgam respectively. The two main restorations, PMCs and anterior composite were included in the statistical analysis. The survival rate of PMCs was significantly higher than anterior composite (p<0.001). The anterior composite restorations survived significantly longer in males (p<0.05). Females had significantly better survival rate of PMCs (p<0.05). There was no statistically significant effect of the operator group of restoration survival. Conclusion: The anterior composite restorations survived significantly longer in males and females had significantly better survival rate of PMCs than males.
引言:发育不全(AI)是一种罕见的遗传性疾病,影响两个牙列。在治疗计划中应考虑年龄、社会经济地位、牙列和AI类型和严重程度等因素。目的:本回顾性研究旨在评估人工智能主要修复方案的生存率以及性别和牙列类型的影响。方法:研究样本包括28份年龄为5-17岁的人工智能患者(15名女性,13名男性)的牙齿记录,这些患者的乳牙和/或恒牙具有前牙和//或后牙修复。每一次修复的命运被分为三类:失败、撤回和审查,并用生存分析的生命表方法进行分析。结果:在233种修复体中,最常用的修复体是预成形金属冠(PMCs),其次是前部复合物、后部复合物、粘合剂铸造、Ketac填充物和汞合金。统计分析包括两种主要的修复体,PMCs和前复合体。PMCs的生存率显著高于前复合体(p<0.001)。前复合体修复体在男性中存活时间显著更长(p<0.05)。女性的PMCs生存率显著更好(p<0.01)。手术组的修复生存率没有统计学显著影响。结论:前部复合修复体在男性中存活时间明显较长,女性PMCs的存活率明显高于男性。
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引用次数: 0
Tualang and Kelulut Honey Reduced Lipopolysaccharides-stimulated Inflammatory Responses of Microglia 土郎和克鲁鲁特蜂蜜降低脂多糖刺激的小胶质细胞炎症反应
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.47
Z. Low, Kaiyuan Tan, Y. Keong, C. Looi, Y. Y. Ooi
Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen species (ROS) and alter their surface marker expression levels. This study used Malaysian honey, Tualang honey (TH), and Kelulut honey (KH) to determine lipopolysaccharide (LPS)-stimulated inflammatory responses of microglia. TH and KH at 0.1% were used in the current study as our findings showed no significant difference in the cell viability between BV2 cells treated with 0.1 % of TH and KH and control group. TH and KH reduced the ROS level significantly by 41.62±1.06% and 49.16±0.63%, respectively, and slightly reduced the expression of co-stimulatory molecules, CD40 and CD11b in LPS-activated BV2 cells. Our preliminary findings proposed an in-depth future study on the anti-inflammatory effect of TH and KH on microglial activation.
小胶质细胞的活动是维持中枢神经系统(CNS)稳态的关键。然而,长时间的小胶质细胞激活与神经退行性疾病的病理有关。激活的小胶质细胞会增加炎症细胞因子、活性氧(ROS)的产生,并改变其表面标记物的表达水平。本研究使用马来西亚蜂蜜、土朗蜂蜜(TH)和克鲁鲁特蜂蜜(KH)来测定脂多糖(LPS)刺激的小胶质细胞炎症反应。本研究使用0.1%的TH和KH,因为我们的研究结果显示,0.1% TH和KH处理的BV2细胞与对照组之间的细胞活力没有显著差异。TH和KH分别显著降低了41.62±1.06%和49.16±0.63%的ROS水平,并轻微降低了lps激活的BV2细胞中共刺激分子CD40和CD11b的表达。我们的初步发现为进一步深入研究TH和KH对小胶质细胞激活的抗炎作用奠定了基础。
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引用次数: 0
Challenges in the use Electronic Medical Records in Middle Eastern Countries: A Narrative Review 中东国家使用电子病历面临的挑战:述评
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.43
A. Hamdan, Rosliza Abdul Manaf, Aidalina Mahmud
Electronic Medical Records (EMRs) have great value in healthcare, as they enhance healthcare quality, decrease costs, optimize patient safety and health care research. Worldwide and particularly in the Middle Eastern countries have pushed for usage and implement EMR systems. However, there were some obstacles and challenges toward implementation of the EMR system. This review aims to look at the challenges and constraints of using and adopting EMR in Middle Eastern countries. Electronic databases of PubMed, country reports, newspaper, magazine articles, and hospital reports between 2008 to 2021 were used. Most common challenges highlighted were high cost of EMR implementation, lack of training, insufficient information technology personnel support, poor acceptance of new technology, confidentiality, and privacy concerns. Understanding the hurdles of using EMR technology in health care setting is essential for decision makers to focus on economic and human factors challenges to enhance the use and acceptance of EMR systems.
电子医疗记录(emr)在医疗保健中具有巨大的价值,因为它们可以提高医疗保健质量、降低成本、优化患者安全和医疗保健研究。在世界范围内,特别是在中东国家,已经推动了电子病历系统的使用和实施。然而,电子病历系统的实施存在一些障碍和挑战。本综述旨在研究中东国家使用和采用电子病历的挑战和制约因素。使用了2008年至2021年间PubMed、国家报告、报纸、杂志文章和医院报告的电子数据库。最常见的挑战是EMR实施的高成本、缺乏培训、信息技术人员支持不足、对新技术的接受程度低、保密性和隐私问题。了解在卫生保健环境中使用电子病历技术的障碍对于决策者关注经济和人为因素挑战以提高电子病历系统的使用和接受度至关重要。
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引用次数: 1
Bilateral Thumb Lymphocutaneous Sporotrichosis 双侧拇指淋巴皮肤孢子菌病
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.52
S. Samsudin
Sporotrichosis is a fungal infection caused by Sporothrix, a thermally dimorphic fungus that affects humans and animals. It is most commonly associated with cutaneous and subcutaneous tissue exposed to fungus-containing soil, moss, or organic material. Sporotrichosis is challenging to diagnose because it can mimic various other dermatological diseases. Thus, as demonstrated in this case, the importance of making a diagnosis based on history and a thorough physical examination, as misdiagnosis can delay proper treatment. A 53-year-old Malay woman presented with bilateral thumb swelling that had been treated with two courses of antibiotics but had failed, resulting in disease progression. Clinical suspicion of lymphocutaneous sporotrichosis was made based on history, physical examination, and investigations finding. The patient was started on an empirical course of Itraconazole 200mg twice daily, and the lesions responded well.
孢子丝菌病是一种由孢子丝菌引起的真菌感染,孢子丝菌是一种影响人类和动物的热二型真菌。它最常见于暴露于含有真菌的土壤、苔藓或有机物质的皮肤和皮下组织。孢子丝菌病很难诊断,因为它可以模拟其他各种皮肤病。因此,正如本例所示,根据病史和彻底的身体检查进行诊断的重要性,因为误诊可能会延误正确的治疗。一名53岁的马来妇女出现双侧拇指肿胀,接受了两个疗程的抗生素治疗,但均失败,导致疾病进展。根据病史、体格检查和调查结果,对淋巴皮肤孢子丝菌病提出临床怀疑。患者开始服用伊曲康唑200mg的经验疗程,每天两次,病变反应良好。
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引用次数: 0
Mantle Cell Lymphona Masquerading as Obstructive Sleep Apnoea 套细胞淋巴瘤伪装成阻塞性睡眠呼吸暂停
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.51
N. L. Ishak, S. T. Tan, Mahfida Mahat
Tonsillar malignancy typically presents with asymmetrical tonsillar enlargement, lesion on the tonsils, sore throat or a neck mass. We report a case of unsuspected tonsillar malignancy in a 56-year-old gentleman who presented with symptoms of obstructive sleep apnoea. His tonsils were grade III bilaterally with normal mucosa. Tonsillectomy was performed to improve patient’s compliance with Continuous Positive Airway Pressure (CPAP) therapy. These tonsillar specimens were reported to be Mantle Cell Lymphoma (MCL) based on the histology and ancillary studies. This case highlights that benign-looking symmetrical tonsillar enlargement can harbour occult malignancy. It is important to note that OSA symptoms may be the presentation for haematological malignancies. Tonsillar specimens should be sent for histopathological examination regardless of the indication to avoid misdiagnosis and delay in treatment.
扁桃体恶性肿瘤通常表现为不对称的扁桃体肿大、扁桃体病变、喉咙痛或颈部肿块。我们报告一例未被怀疑扁桃体恶性肿瘤在一个56岁的绅士谁提出了阻塞性睡眠呼吸暂停的症状。双侧扁桃体III级,粘膜正常。扁桃体切除术是为了提高患者对持续气道正压(CPAP)治疗的依从性。这些扁桃体标本根据组织学和辅助研究报告为套细胞淋巴瘤(MCL)。本病例强调良性对称扁桃体肿大可隐匿恶性肿瘤。值得注意的是,呼吸暂停症状可能是血液系统恶性肿瘤的表现。不论指征如何,均应送扁桃体标本进行组织病理学检查,以免误诊和延误治疗。
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引用次数: 0
Nutritional Factors Determining Body Fat Percentage of Adolescent Boys in 5 Districts of Jakarta 雅加达5个地区青少年男孩体脂百分比的营养因素
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.30
L. Sitoayu, N. Gifari, Putri Ronitawati, Rachmanida Nuzrina, Mury Kuswari
Introduction: Adolescence is one of the life stages that play a key role and is also affected by the epidemiology transition as the result of the development of the era. Consuming a lot of fast food and junk food nowadays causes adolescents, both girls and boys, to be subjected to nutritional problems such as the high body fat percentage. Adolescent boys even tend to be unaware of their health. This study aims to analyse nutritional factors which have an effect on body fat percentage in adolescent boys. Methods: This study was performed involving 1046 high school students in 5 Jakarta districts. Spearman’s correlation and multiple linear regression were used for the data analysis of this study. Results: The result shows that there was a relationship between BMI-for-age, energy and macronutrient intakes, and body fat percentage. Adolescents with excessive intakes got affected by their body fat percentage, although their BMI-for-age is normal. The result of multivariate analysis suggests that BMI-for-age had the most effect on body fat percentage. Conclusion: There needs to be a regular education for adolescent boys to be aware of their body fat percentage and other factors that have an effect on it.
引言:青春期是人生中起关键作用的阶段之一,也受到时代发展导致的流行病学转变的影响。如今,大量食用快餐和垃圾食品会导致青少年,包括男孩和女孩,出现营养问题,如高体脂率。十几岁的男孩甚至往往不知道自己的健康状况。本研究旨在分析影响青春期男孩体脂百分比的营养因素。方法:本研究涉及雅加达5个地区的1046名高中生。本研究采用Spearman相关和多元线性回归进行数据分析。结果:研究结果表明,年龄、能量和大量营养素摄入量的BMI与体脂百分比之间存在相关性。摄入过多的青少年会受到身体脂肪百分比的影响,尽管他们的BMI在年龄上是正常的。多变量分析的结果表明,BMI对体脂百分比的影响最大。结论:需要对青春期男孩进行定期教育,让他们意识到自己的体脂百分比和其他影响体脂百分比的因素。
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引用次数: 0
Face and Content Validity of a Handwriting Program for Children With Handwriting Difficulties 手写困难儿童手写程序的人脸和内容有效性
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.34
Mahfuzah Zainol, Masne Kadar, Nor Afifi Razaob, Farahiyah Wan Yunus
Introduction: Occupational therapists have been developing various handwriting intervention that has fundamental occupational goals with known validity to guide professional practice in the treatment of children with handwriting difficulties. This study aimed to explore the development and content validation of a developed handwriting intervention programme for children with handwriting difficulties. Methods: This study employed a combination of qualitative and quantitative methodology based on the sequential exploratory design in two main stages. The first stage is the focus group discussion and followed by a validation procedure using face and content validity scored by the expert reviewers. A total of thirteen experts participated in this study. Results: The findings were analyzed thematically according to physical appearance, language used, and content in the developed programme. The face and content validity report a convincing value, ranging from 0.99 to 1.00 of S-CVI values on four aspects, relevancy, clarity, simplicity, and ambiguity in the developed programme. Conclusion: This study provided preliminary approval for the development and validation of a handwriting intervention programme for children with handwriting difficulties to support the demand in the Malaysian school curriculum.
引言:职业治疗师一直在开发各种具有基本职业目标且有效性已知的笔迹干预措施,以指导治疗笔迹困难儿童的专业实践。本研究旨在探索为有书写困难的儿童开发的手写干预计划的开发和内容验证。方法:本研究采用定性和定量相结合的方法,分两个主要阶段进行顺序探索设计。第一阶段是焦点小组讨论,然后是使用专家评审员评分的面部和内容有效性的验证程序。共有13名专家参与了这项研究。结果:根据身体外观、语言使用和开发的节目内容对研究结果进行了主题分析。面部和内容的有效性报告了一个令人信服的值,在四个方面,即相关性、清晰性、简单性和模糊性,S-CVI值的范围从0.99到1.00不等。结论:本研究为制定和验证针对书写困难儿童的书写干预计划提供了初步批准,以支持马来西亚学校课程的需求。
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引用次数: 0
Self Efficacy and Nurses’ Disaster Competency in Disaster Preparedness Management 防灾管理中的自我效能感与护士灾害能力
Pub Date : 2023-05-15 DOI: 10.47836/mjmhs.19.3.40
I. Khairina, Nelwati Nelwati, Esthika Ariany Maisa
Introduction: Natural disasters are catastrophic events with geological, and hydrological origins such as earthquakes, floods, hurricanes, landslides that can cause fatalities, property damage and social environmental disruption. The threat of geological disasters like tsunami and earthquakes as well as the threat of hydrometeorology, such as floods, landslides, hurricanes, and fires normally occur in Indonesia. Nurses have a role to play in educating the public and engaging in the crisis. This research aims to determine the relationship between nurses’ self-efficacy and disaster preparedness management competency. Method: This research is a quantitative study with a cross-sectional approach. The population consisted of nurses who served in the Emergency Room at three disaster referral hospitals in Padang. According to the inclusion criteria, nurses who participated in this study were selected by the purposive sampling method as 1st level disaster nurses, as many as 60 nurses. The data collection was carried out from August to October 2020. Results: This research shows that there was a significant relationship between nurses’ self-efficacy and disaster preparedness management with a p-value of 0.0001 and a strong relationship with a value of r = 0.673. There was a relationship between disaster management competencies and disaster preparedness management with a p-value of 0.0001, the strength of the relationship was moderate with a value of r = 0.473. Conclusion: The nurse is one of the resources responsible for disaster preparedness management in the community. Educating the nurses about disaster preparedness management increases the nurses’ readiness. Nurses can take action in managing the disaster response.
简介:自然灾害是由地质和水文原因引起的灾难性事件,如地震、洪水、飓风、山体滑坡,可能造成死亡、财产损失和社会环境破坏。海啸和地震等地质灾害的威胁以及洪水、山体滑坡、飓风和火灾等水文气象的威胁通常发生在印度尼西亚。护士在教育公众和参与危机中可以发挥作用。本研究旨在探讨护士自我效能感与灾害准备管理能力之间的关系。方法:本研究采用横断面方法进行定量研究。人口由在巴东三家灾难转诊医院急诊室服务的护士组成。根据纳入标准,采用有针对性的抽样方法,选择参与本研究的护士为一级灾难护士,多达60名。数据收集于2020年8月至10月进行。结果:本研究表明,护士的自我效能感与灾害准备管理之间存在显著关系,p值为0.0001,r值为0.673。灾害管理能力和备灾管理之间存在关系,p值为0.0001,关系强度适中,r值为0.473。结论:护士是负责社区防灾管理的资源之一。对护士进行防灾管理教育,提高了护士的应变能力。护士可以采取行动管理救灾工作。
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引用次数: 0
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Malaysian Journal of Medicine and Health Sciences
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