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Ewing Sarcoma of Kidney: A Rare Entity 肾脏尤文肉瘤:罕见实体
IF 0.3 Pub Date : 2024-06-07 DOI: 10.1055/s-0044-1786993
V. Aithal A., Sajitha K., M. Mathias
Abstract Primary renal origin of Ewing sarcoma/PNET (primitive neuroectodermal tumor) is a rare entity in the adult population and has an aggressive outcome. The entity was first coined by Arthur Purdy stout in 1918 and recognized under family of small round cell tumor. Radiologically it is difficult to distinguish from primary clear cell carcinoma of kidney from Ewing/PNET. Diagnosis of this requires histopathology, immunohistochemistry (IHC), and cytogenetics studies. A 40-year-old female presented with hematuria and radiology found a mass lower pole of left kidney with extension into renal hilum. Nephrectomy was done for the case and the histopathology diagnosis of small round cell tumor of left kidney was given. Followed by IHC, diagnosis of malignant round cell tumor was suggestive of Ewing sarcoma. Microscopy showed cells with small, round, hyperchromatic nuclei, scant cytoplasm, and inconspicuous nucleoli. Increased mitosis was noted (15/10 high power field). Multiple foci of pseudorosettes, areas of hemorrhage, and necrosis lymphovascular emboli were seen. IHC done outside showed NKX 2-2, synaptophysin positivity, CD99 diffuse membranous positivity, cytokeratin perinuclear dot like positivity, and negative for CD20, CD3, desmin, CD34, S100, and Pax8. Impression of malignant round cell tumor was suggestive of Ewing sarcoma. Ewing sarcoma is one of the rare yet highly aggressive tumors. This should be kept as differential diagnosis in young adults with renal mass, as on radiologically it cannot be differentiated from renal cell carcinoma. Diagnosis of Ewing sarcoma is done using histopathology, IHC, and cytogenetic study. Early diagnosis helps in initiation of surgery, chemotherapy, and radiotherapy and helps in increasing the survival rate.
摘要 原发性肾源性尤文肉瘤/PNET(原始神经外胚层瘤)在成人中十分罕见,且具有侵袭性。阿瑟-珀迪-斯托特(Arthur Purdy stout)于 1918 年首次提出该实体,并将其归入小圆细胞瘤家族。从放射学角度来看,它很难与原发性肾透明细胞癌和 Ewing/PNET 区分开来。其诊断需要进行组织病理学、免疫组化(IHC)和细胞遗传学研究。一名 40 岁女性因血尿就诊,放射科检查发现左肾下极肿块,并向肾门延伸。对该病例进行了肾切除术,组织病理学诊断为左肾小圆形细胞瘤。随后进行了 IHC 检测,恶性圆形细胞瘤的诊断提示为尤文肉瘤。显微镜检查显示,细胞核小而圆,高色素,胞浆稀少,核小体不明显。有丝分裂增多(15/10 高倍视野)。可见多个假灶、出血区和坏死淋巴管栓塞。外部 IHC 显示 NKX 2-2、突触素阳性、CD99 弥漫膜阳性、细胞角蛋白核周点状阳性,CD20、CD3、desmin、CD34、S100 和 Pax8 阴性。恶性圆形细胞瘤的印象提示为尤文肉瘤。尤文肉瘤是一种罕见但侵袭性极强的肿瘤。对于患有肾肿块的年轻成人,应将其作为鉴别诊断,因为从放射学角度来看,它无法与肾细胞癌区分开来。尤文肉瘤的诊断需要通过组织病理学、IHC 和细胞遗传学研究来完成。早期诊断有助于启动手术、化疗和放疗,并有助于提高存活率。
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引用次数: 0
Sarcomatoid Cholangiocarcinoma: An Unusual Tumor Posing Diagnostic Challenges 肉瘤样胆管癌:一种给诊断带来挑战的罕见肿瘤
IF 0.3 Pub Date : 2024-06-07 DOI: 10.1055/s-0044-1787557
Pooja Vijayan, Kishan Prasad Hosapatna Laxminarayana, Jayaprakash Shetty K., Shruthi Shruthi, A. K.
Abstract Sarcomatoid intrahepatic cholangiocarcinoma is an uncommon tumor that accounts for fewer than 1% of hepatobiliary system cancers. Frequently exhibits weight loss, fever, and stomach pain. This case study describes a 72-year-old woman who had been experiencing nausea, vomiting, and stomach pain for the previous 2 months. Histopathology and immunohistochemistry confirmed the diagnosis of sarcomatoid cholangiocarcinoma.
摘要 肉瘤样肝内胆管癌是一种不常见的肿瘤,占肝胆系统癌症的 1%以下。肉瘤样肝内胆管癌通常表现为体重减轻、发热和胃痛。本病例研究描述了一名 72 岁的女性,她在过去两个月中一直感到恶心、呕吐和胃痛。组织病理学和免疫组化确诊为肉瘤样胆管癌。
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引用次数: 0
Identification of Factors Associated with Nonspecific Neck Pain in Working Women 职业女性非特异性颈痛的相关因素识别
IF 0.3 Pub Date : 2024-06-07 DOI: 10.1055/s-0044-1786994
Reetika Yadav, Pragya Kumar, J. K. Chawla
Abstract Objectives  Neck pain is a broad term that encompasses both nonspecific neck pain and neck pain-related disorders. It causes discomfort, impaired quality of life, disability, and affects workability alike in men as well as women. This study was designed to determine prevalence and evaluate the association of different factors with the occurrence of nonspecific neck pain in working women. Materials and Methods  A cross-sectional study was performed on working women ( n  = 196) age group between 25 and 53 years. A Google Form of the Questionnaire for the Evaluation of Risk Factors Associated With Non-Specific Neck Pain scale and Neck Disability Index (NDI) scale was given to individuals and further objective assessment of physical factors was conducted. Statistical Analysis  The association between individual, workplace, lifestyle, physical and psychological factors, and NDI levels of disability was also investigated using Pearson's correlation test and the chi-squared test using SPSS version 28.0. Results  Frequency of nonspecific neck pain in working women was 47.55%. Marital status was a significant (χ 2  = 8.89) factor toward occurrence of neck pain in working women. Number of working hours/week (χ 2  = 19.97), number of hours spend for entertainment on the computer (χ 2  = 41.84), and height of keyboard & mouse (χ 2  = 18.52) were significant factors leading to neck pain at workplace. Lifestyle factors such as mobile phones usage ( p -value = 0.02) and posture assumed while using them (χ 2  = 19.56) were significantly associated with neck disability. Levels of disability were significantly influenced by physical factors like tragus-to-wall tests ( r  = 0.33) and cervical flexion and extension ranges ( r  = 0.41 and r  = 0.31). Importantly, psychological factors were strongly associated with neck pain and disability. Conclusion  Factors under psychological, workplace, and lifestyle domains were found significantly associated with nonspecific neck pain in working women.
摘要 目的 颈痛是一个广义的术语,包括非特异性颈痛和与颈痛相关的疾病。无论男女,颈痛都会导致不适、生活质量下降、残疾并影响工作能力。本研究旨在确定职业女性非特异性颈痛的患病率,并评估不同因素与非特异性颈痛发生的关联。材料和方法 对 25-53 岁年龄段的职业女性(196 人)进行了横断面研究。研究人员使用谷歌非特异性颈部疼痛相关风险因素评估问卷和颈部残疾指数(NDI)量表,并对身体因素进行了进一步的客观评估。统计分析 使用 SPSS 28.0 版进行皮尔逊相关检验和卡方检验,研究个人、工作场所、生活方式、身体和心理因素与 NDI 残疾程度之间的关联。结果 职业女性非特异性颈部疼痛的发生率为 47.55%。婚姻状况是职业女性发生颈部疼痛的一个重要因素(χ 2 = 8.89)。每周工作时数(χ 2 = 19.97)、使用电脑娱乐的时数(χ 2 = 41.84)以及键盘和鼠标的高度(χ 2 = 18.52)是导致工作场所颈部疼痛的重要因素。使用手机(p -value = 0.02)和使用手机时的姿势(χ 2 = 19.56)等生活方式因素与颈部残疾显著相关。外耳对墙壁测试(r = 0.33)和颈椎屈伸幅度(r = 0.41 和 r = 0.31)等物理因素对残疾程度有明显影响。重要的是,心理因素与颈部疼痛和残疾密切相关。结论 发现心理、工作场所和生活方式等方面的因素与职业女性的非特异性颈部疼痛有很大关系。
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引用次数: 0
Occupational Stress, Strain, and Coping among Nursing Personnel: A Hospital-Based Cross-sectional Study 护理人员的职业压力、紧张和应对:一项基于医院的横断面研究
IF 0.3 Pub Date : 2024-06-07 DOI: 10.1055/s-0044-1786992
Shamili Kowshik, Dhanpal Hn, Rahul Shil
Abstract Background  Nurses are the backbone of the health care system and the largest health care force in the world. They work in multidisciplinary areas in hospitals, nursing homes, government and private sectors, and research and development, which makes them the most stressful personnel in clinical areas. Objectives  This paper aims to explore occupational stress, strain, and coping among nurses working in a hospital in Bengaluru. Methodology  A nonexperimental hospital-based cross-sectional study was conducted from November 2, 2022, to December 2, 2022, using a purposive sampling technique. A total of 77 nurses from different areas participated in the study. Data were collected by the researcher himself through the revised version of the Occupational Stress Inventory scale. Descriptive statistics were used with the mean, standard deviation, frequency, and percentage. To check the association, chi-square analysis was used. Results  The research shows that the majority of the nurses had maladaptive stress in terms of role insufficiency, role ambiguity, role boundary, and physical environment (PE). It was observed that there was a high level of vocational strain (VS) and interpersonal strain with an average social support system (SS) among nurses. A significant association was found between gender and occupational role questionnaire (ORQ) factors like PE, designation of the nurse and ORQ in the area of responsibility, and PE of the working area. In the personal strain questionnaire factor, VS was significantly associated with gender. Furthermore, a significant association was also found between gender and personal resources questionnaire factors like self-care coping and SS coping skills. Conclusion  Our data suggested a moderate to high level of occupational stress with less SS among nurses. Consequently, it is imperative for health care organizations to acknowledge the existence of occupational stress and collaborate toward devising a resolution, enabling nurses to provide patients with optimal care.
摘要 背景 护士是医疗保健系统的中坚力量,也是世界上最大的医疗保健队伍。他们在医院、疗养院、政府和私营部门以及研发部门等多学科领域工作,这使他们成为临床领域压力最大的人员。本文旨在探讨在班加罗尔一家医院工作的护士的职业压力、应变和应对方法。方法 采用目的性抽样技术,于 2022 年 11 月 2 日至 2022 年 12 月 2 日开展了一项基于医院的非实验性横断面研究。共有 77 名来自不同地区的护士参与了研究。数据由研究者本人通过修订版职业压力量表收集。描述性统计使用了平均数、标准差、频率和百分比。为检验相关性,采用了卡方分析法。结果 研究表明,大多数护士在角色不足、角色模糊、角色边界和物理环境(PE)方面存在适应不良的压力。研究发现,护士的职业压力(VS)和人际关系压力较高,社会支持系统(SS)一般。研究发现,性别与职业角色问卷(ORQ)因素(如 PE、护士的称谓与责任区的 ORQ 以及工作区的 PE)之间存在明显关联。在个人压力问卷因素中,VS 与性别显著相关。此外,性别与个人资源问卷因素(如自我护理应对和 SS 应对技能)之间也存在明显关联。结论 我们的数据表明,护士的职业压力为中度至高度紧张,而 SS 较小。因此,医疗机构必须承认职业压力的存在,并合作制定解决方案,使护士能够为患者提供最佳护理。
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引用次数: 0
A Report of a Rare Case of Bi-Rooted Bimaxillary Deciduous Canines 双根双颌落叶犬齿罕见病例报告
IF 0.3 Pub Date : 2024-06-07 DOI: 10.1055/s-0044-1787555
Mohamed Shaji, S. Bhandary, Simna Abhilash, Dhvani Abhijit Tanna
Abstract Primary teeth have considerably fewer anomalies than permanent teeth. Rarely does a primary canine have two roots. This kind of strange abnormality could cause issues with exfoliation or extraction. The significance of anomalies must be emphasized to make a proper diagnosis and ensure a successful course of therapy. As far as we are aware, Dakshina Kannada district has never previously reported a maxillary deciduous canine with two roots. The objective of this case study was to raise awareness of the potential morphological changes in deciduous canines and to emphasize the implications of precise diagnosis and radiographic imaging from various viewpoints. To allow a better treatment outcome and prevent unintended problems, clinicians should take into account all potential tooth abnormalities or anomalies, following a periodic intraoral and radiographic evaluations.
摘要 与恒牙相比,乳牙的异常情况要少得多。犬齿很少有双根的。这种奇怪的异常可能会导致脱落或拔牙问题。必须强调异常的重要性,以便做出正确的诊断,确保治疗的成功。据我们所知,达克希纳卡纳达地区以前从未报道过上颌脱落犬齿有两条牙根的情况。本病例研究旨在提高人们对落叶犬齿潜在形态变化的认识,并从不同角度强调精确诊断和放射成像的意义。为了取得更好的治疗效果并防止意外问题的发生,临床医生应在定期进行口内和放射影像学评估后,考虑到所有潜在的牙齿异常或异常现象。
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引用次数: 0
Early Physical Therapy Management of a Patient with Diaphragmatic Eventration Following Diaphragmatic Plication: A Case Report 膈肌钳夹术后膈肌内陷患者的早期物理治疗管理:病例报告
IF 0.3 Pub Date : 2024-06-04 DOI: 10.1055/s-0044-1782642
Dipika Prajapati, Abeeshna Ashok
Diaphragmatic plication is the recommended surgical procedure for the treatment of diaphragmatic eventration in those who have failed conservative care. The present case report describes a 63-year-old male patient who presented with breathlessness on exertional activities. Chest X-ray and Computed Tomography (CT) of the thorax revealed diaphragmatic eventration on the right side. After failed conservative management, the patient underwent diaphragmatic plication surgery and was followed up with postoperative physical therapy management. Physical therapy intervention was started from 3 days postsurgery and was continued for 1 week. The treatment goals focused on reducing breathlessness, reducing pain on the incision site, preventing postoperative complications, and improving functional capacity. The present study highlights the benefits of early physical therapy interventions including incentive spirometer, dyspnea relieving techniques, Transcutaneous Electrical Nerve Stimulation (TENS), and light- to moderate-intensity aerobic exercises in the patient after plication surgery.
膈肌成形术是治疗保守治疗失败的膈肌偶发症的推荐手术方法。本病例报告描述了一名 63 岁的男性患者,他在劳累时出现呼吸困难。胸部 X 光片和计算机断层扫描(CT)显示其右侧横膈膜偶发症。保守治疗无效后,患者接受了横膈膜固定手术,并在术后接受了物理治疗。物理治疗干预从术后 3 天开始,持续 1 周。治疗目标主要集中在减少呼吸困难、减轻切口部位疼痛、预防术后并发症和提高功能能力上。本研究强调了早期物理治疗干预的益处,包括激励式肺活量计、呼吸困难缓解技术、经皮神经电刺激(TENS)和轻中度强度的有氧运动。
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引用次数: 0
Assessment of Knowledge on Cervical Cancer among Women with a View to Develop Information Booklet 评估妇女对宫颈癌的了解程度,以便编制信息手册
IF 0.3 Pub Date : 2024-06-04 DOI: 10.1055/s-0044-1787132
Chetan Naik, Priya Jyothi Monteiro
Introduction Cervical cancer manifests in the cervix cells, the lower part of the uterus connecting to the vagina. Similar to other cancers, the exact cause of cervical cancer remains uncertain and idiopathic. However, it is established that the human papilloma virus plays a significant role in initiating cellular changes in the cervix. In India, the lack of cancer awareness and screening facilities results in many women presenting at an advanced and deadly stage of the disease, negatively impacting their prognosis and clinical outcomes. Methods A total of 255 women aged between 18 and 45 years, who were either patients or accompanying bystanders at a tertiary care hospital, were selected using purposive sampling technique. Statistical Analysis Descriptive statistics were used to represent the sociodemographic characteristics levels. Association of sociodemographic variables levels is determined using chi-squared test. Results The mean age of the participants was 31.83 ± 6.83 years, majority (162 [63.5%]) were living in a rural area, most (175 [68.6%]) of the participants were married, majority (254 [99.6%]) of the subjects were not having any family history of cervical cancer, most (202 [79.2%]) of the participants were having a single sexual partner, majority (108 [42.4%]) were not having any information on cervical cancer, most (134 [52.5%]) of the participants were unaware of cervical cancer screening, 39 (15.3%) were aware but delaying, 26 (10.2%) were aware, 17 (6.7%) were aware but not decided to do, 16 (6.3%) were aware but undecided, and 21 (8.2%) were in “others” category. Conclusion Although women are having good knowledge and positive attitude toward cervical cancer screening and prevention, still there is a gap to transform it into practice. There is a need for more educational programs to connect identified knowledge slits and uplift regular practice of cervical cancer screening.
导言 宫颈癌主要发生在子宫颈细胞上,即子宫下部连接阴道的部位。与其他癌症类似,宫颈癌的确切病因仍不确定,而且是特发性的。不过,已经确定的是,人类乳头状瘤病毒在引发宫颈细胞变化方面起着重要作用。在印度,由于缺乏癌症意识和筛查设施,许多妇女在疾病晚期和致命阶段才就诊,这对她们的预后和临床结果产生了负面影响。方法 采用目的性抽样技术,共选取了 255 名年龄在 18 至 45 岁之间的妇女,她们要么是一家三级医院的患者,要么是旁观者。统计分析 采用描述性统计来表示社会人口学特征水平。社会人口学变量水平之间的关联采用卡方检验。结果 参与者的平均年龄为 31.83 ± 6.83 岁,大多数(162 [63.5%])居住在农村地区,大多数(175 [68.6%])已婚,大多数(254 [99.6%])没有宫颈癌家族史,大多数(202 [79.2%])只有一个性伴侣,大多数(108 [42.大多数参与者(134 人 [52.5%])不了解宫颈癌筛查,39 人(15.3%)了解但拖延,26 人(10.2%)了解,17 人(6.7%)了解但未决定,16 人(6.3%)了解但未决定,21 人(8.2%)属于 "其他 "类别。结论 虽然妇女对宫颈癌筛查和预防有良好的认识和积极的态度,但要将其转化为实践仍有差距。有必要开展更多的教育计划,以弥补已发现的知识缺陷,并提高宫颈癌筛查的常规做法。
{"title":"Assessment of Knowledge on Cervical Cancer among Women with a View to Develop Information Booklet","authors":"Chetan Naik, Priya Jyothi Monteiro","doi":"10.1055/s-0044-1787132","DOIUrl":"https://doi.org/10.1055/s-0044-1787132","url":null,"abstract":"\u0000 Introduction Cervical cancer manifests in the cervix cells, the lower part of the uterus connecting to the vagina. Similar to other cancers, the exact cause of cervical cancer remains uncertain and idiopathic. However, it is established that the human papilloma virus plays a significant role in initiating cellular changes in the cervix. In India, the lack of cancer awareness and screening facilities results in many women presenting at an advanced and deadly stage of the disease, negatively impacting their prognosis and clinical outcomes.\u0000 Methods A total of 255 women aged between 18 and 45 years, who were either patients or accompanying bystanders at a tertiary care hospital, were selected using purposive sampling technique.\u0000 Statistical Analysis Descriptive statistics were used to represent the sociodemographic characteristics levels. Association of sociodemographic variables levels is determined using chi-squared test.\u0000 Results The mean age of the participants was 31.83 ± 6.83 years, majority (162 [63.5%]) were living in a rural area, most (175 [68.6%]) of the participants were married, majority (254 [99.6%]) of the subjects were not having any family history of cervical cancer, most (202 [79.2%]) of the participants were having a single sexual partner, majority (108 [42.4%]) were not having any information on cervical cancer, most (134 [52.5%]) of the participants were unaware of cervical cancer screening, 39 (15.3%) were aware but delaying, 26 (10.2%) were aware, 17 (6.7%) were aware but not decided to do, 16 (6.3%) were aware but undecided, and 21 (8.2%) were in “others” category.\u0000 Conclusion Although women are having good knowledge and positive attitude toward cervical cancer screening and prevention, still there is a gap to transform it into practice. There is a need for more educational programs to connect identified knowledge slits and uplift regular practice of cervical cancer screening.","PeriodicalId":40092,"journal":{"name":"Journal of Health and Allied Sciences NU","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitude of Students and Audiologist Professionals towards Patient-Centered Care in Audiology 学生和听力学专业人员对听力学中以患者为中心的护理的态度
IF 0.3 Pub Date : 2024-06-04 DOI: 10.1055/s-0044-1787107
Swati Goyal, Prajwal Kumar E., Chethana P. Murthy, Prashanth P. Prabhu
Background: In audiology, the service model has always been practitioner-centric or techno-centric. However, the model has evolved into client-centric over the years. Patient centeredness is a growing trend in healthcare as it improves the outcomes of the intervention and patient satisfaction. This study was conducted with the aim of determining the preferences of undergraduates, postgraduates, and working professionals toward a patient-centered framework for the service delivery model. Materials & methods: This study employed a survey design where the data was collected using an online questionnaire (patient–practitioner orientation scale). A total of 60 individuals participated in the survey which included undergraduate students, postgraduate students, and working professionals. Results: The analysis of the findings revealed that there was no significant difference in the attitude toward preferences between postgraduate students and working professionals. However, a significant difference was found between undergraduate students and working professionals and undergraduate students and postgraduate students. Conclusions: This study concludes that the postgraduate students and working professionals are more patient-centric than the undergraduate students. However, further studies are needed to compare the attitudes of working professionals with varying years of work experience.
背景:在听力学领域,服务模式一直是以从业人员为中心或以技术为中心。然而,多年来,这种模式已演变为以客户为中心。以患者为中心是医疗保健领域日益增长的趋势,因为它能提高干预效果和患者满意度。本研究旨在确定本科生、研究生和在职专业人员对以患者为中心的服务提供模式框架的偏好。材料与方法:本研究采用调查设计,通过在线问卷(患者-从业人员导向量表)收集数据。共有 60 人参与了调查,其中包括本科生、研究生和在职专业人员。调查结果分析结果显示,研究生和在职专业人员对偏好的态度没有显著差异。但是,本科生和在职专业人员之间以及本科生和研究生之间存在明显差异。结论本研究得出结论,研究生和在职专业人员比本科生更以患者为中心。不过,还需要进一步研究,比较不同工作年限的在职专业人员的态度。
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引用次数: 0
Elucidating Genes and Transcription Factors of Human Peripheral Blood Lymphocytes Involved in the Cellular Response upon Exposure to Ionizing Radiation for Biodosimetry and Triage: An In Silico Approach 阐明人类外周血淋巴细胞在暴露于电离辐射时参与细胞反应的基因和转录因子,用于生物模拟和分流:硅学方法
IF 0.3 Pub Date : 2024-06-04 DOI: 10.1055/s-0044-1782634
Pavan Gollapalli, Vishakh Radhakrishna, S. N, Tamizh Selvan Gnanasekaran
Background Gene expression–based biodosimetry is a promising method for estimating radiation dose following exposure. A panel of highly radio-responsive genes in human peripheral blood was used in the current investigation to create and evaluate a unique gene expression–based radiological biodosimetry method. Methodology In human cellular research, we reviewed the literature on genes and proteins correlating to radiation response in vivo and in vitro. We looked at two publicly accessible independent radiation response gene expression profiles (GSE1977 and GSE1725) and identified the differentially expressed genes (DEGs). Results The obtained data exhibited 42 genes with substantial differential expression, 25 of which were upregulated and 17 of which were downregulated in ionizing radiation exposure groups compared with control groups. The gene ontology enrichment analysis revealed that the hub genes are significantly involved in the regulation of the mitotic cell cycle phase transition, regulation of the mitotic cell cycle, and mitotic cell cycle checkpoint signaling. Out of the 42 DEGs, four top genes (CDK1, CCNB1, UBC, and UBB) were obtained through network centrality features. However, the multicomponent filtering procedure for radiation response genes resulted in cyclin-dependent kinase 1 (CDK1) as a critical gene in the dataset curated. Conclusion Our findings suggest the possibility of discovering novel gene connections involved in the cellular response of human peripheral blood lymphocytes upon exposure to ionizing radiation.
背景 基于基因表达的生物剂量测定法是一种很有前途的估算辐射照射剂量的方法。本研究利用人体外周血中的一组高放射反应基因来创建和评估一种独特的基于基因表达的放射生物剂量学方法。方法 在人体细胞研究中,我们查阅了与体内和体外辐射反应相关的基因和蛋白质的文献。我们查阅了两份可公开获取的独立辐射响应基因表达谱(GSE1977 和 GSE1725),并确定了差异表达基因(DEGs)。结果 所获数据显示,与对照组相比,电离辐射暴露组有 42 个基因表达存在显著差异,其中 25 个基因上调,17 个基因下调。基因本体富集分析显示,这些中枢基因明显参与了有丝分裂细胞周期相变调控、有丝分裂细胞周期调控和有丝分裂细胞周期检查点信号转导。在 42 个 DEGs 中,通过网络中心性特征得到了四个顶级基因(CDK1、CCNB1、UBC 和 UBB)。然而,辐射反应基因的多组分过滤程序导致细胞周期蛋白依赖性激酶 1(CDK1)成为数据集中的关键基因。结论 我们的研究结果表明,有可能发现涉及人类外周血淋巴细胞暴露于电离辐射时的细胞反应的新型基因连接。
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引用次数: 0
Dynamic Interplay of Age and Protein Malnutrition on the Pharmacokinetic Profile of Acetaminophen in Wistar Rats 年龄和蛋白质营养不良对对乙酰氨基酚在 Wistar 大鼠中的药代动力学特征的动态影响
IF 0.3 Pub Date : 2024-06-03 DOI: 10.1055/s-0044-1786996
Varsha Augustin, Vinitha D'Souza, Madhura R. J., M. Badanthadka, B. Mamatha, K. Vijayanarayana
Objectives Age and protein malnutrition (PMN) are well-known determinants of drug pharmacokinetics. The combined influence of age and nutrition on the pharmacokinetics of acetaminophen (APAP) remains insufficiently explored; therefore, this study investigates the role of age and PMN on APAP pharmacokinetics. Materials and Methods Wistar rat weanlings were divided into four groups. Groups ND-5 (n = 6) and ND-18 (n = 6) were fed with normal diet (ND, 18% protein) and groups LPD-5 (n = 6) and LPD-18 (n = 6) were fed with low-protein diet (LPD, 10%) for 5 and 18 months, respectively. Blood samples were collected at different time intervals (0, 0.5, 1, 3, 6, 24, 36, and 48 hours), and plasma was separated and analyzed for APAP using high-performance liquid chromatography. Pharmacokinetic data was analyzed by the noncompartmental model using Phoenix WinNonlin 8.3 software. Results The pharmacokinetic parameters of APAP were elevated in both LPD groups compared with their age-matched controls. The average area under the curve was increased by approximately 131% (LPD-5) and 17.57% (LPD-18), and the average maximum plasma concentrations (Cmax) was increased by 33.5% (LPD-5) and 26.3% (LPD-18) compared with their respective age-matched controls. The average mean retention time was approximately 114% (LPD-5) and 17.4% (LPD-18) higher than their respective age-matched controls, whereas the clearance rate (Cl/F) and volume distribution (Vz/F) of the drug were significantly lower. Consequently, there was a 68.5% (ND-5) and 4.73% (ND-18) prolongation in the mean half-life of APAP. Conclusion The altered pharmacokinetics may arise from the intricate interplay of dietary and age influences on physiology, protein binding, and cytochrome P450enzyme activity/expression. However, the exact reason requires further investigation for a better understanding of vulnerable populations.
目的 众所周知,年龄和蛋白质营养不良(PMN)是药物代谢动力学的决定因素。年龄和营养对对乙酰氨基酚(APAP)药代动力学的综合影响尚未得到充分探讨,因此,本研究探讨了年龄和 PMN 对 APAP 药代动力学的作用。材料与方法 Wistar 断奶大鼠分为四组。ND-5组(n = 6)和ND-18组(n = 6)喂食正常饮食(ND,18%蛋白质),LPD-5组(n = 6)和LPD-18组(n = 6)分别喂食低蛋白饮食(LPD,10%)5个月和18个月。在不同时间间隔(0、0.5、1、3、6、24、36 和 48 小时)采集血样,使用高效液相色谱法分离和分析血浆中的 APAP。药代动力学数据采用 Phoenix WinNonlin 8.3 软件的非室模型进行分析。结果 与年龄匹配的对照组相比,LPD 两组患者的 APAP 药代动力学参数均有所升高。与各自年龄匹配的对照组相比,平均曲线下面积增加了约 131%(LPD-5)和 17.57%(LPD-18),平均最大血浆浓度(Cmax)增加了 33.5%(LPD-5)和 26.3%(LPD-18)。与年龄匹配的对照组相比,平均滞留时间分别延长了约 114%(LPD-5)和 17.4%(LPD-18),而药物清除率(Cl/F)和体积分布(Vz/F)则明显降低。因此,APAP 的平均半衰期分别延长了 68.5%(ND-5)和 4.73%(ND-18)。结论 药代动力学的改变可能是由于饮食和年龄对生理、蛋白质结合和细胞色素 P450 酶活性/表达的影响错综复杂。不过,具体原因还需要进一步研究,以便更好地了解易感人群。
{"title":"Dynamic Interplay of Age and Protein Malnutrition on the Pharmacokinetic Profile of Acetaminophen in Wistar Rats","authors":"Varsha Augustin, Vinitha D'Souza, Madhura R. J., M. Badanthadka, B. Mamatha, K. Vijayanarayana","doi":"10.1055/s-0044-1786996","DOIUrl":"https://doi.org/10.1055/s-0044-1786996","url":null,"abstract":"\u0000 Objectives Age and protein malnutrition (PMN) are well-known determinants of drug pharmacokinetics. The combined influence of age and nutrition on the pharmacokinetics of acetaminophen (APAP) remains insufficiently explored; therefore, this study investigates the role of age and PMN on APAP pharmacokinetics.\u0000 Materials and Methods Wistar rat weanlings were divided into four groups. Groups ND-5 (n = 6) and ND-18 (n = 6) were fed with normal diet (ND, 18% protein) and groups LPD-5 (n = 6) and LPD-18 (n = 6) were fed with low-protein diet (LPD, 10%) for 5 and 18 months, respectively. Blood samples were collected at different time intervals (0, 0.5, 1, 3, 6, 24, 36, and 48 hours), and plasma was separated and analyzed for APAP using high-performance liquid chromatography. Pharmacokinetic data was analyzed by the noncompartmental model using Phoenix WinNonlin 8.3 software.\u0000 Results The pharmacokinetic parameters of APAP were elevated in both LPD groups compared with their age-matched controls. The average area under the curve was increased by approximately 131% (LPD-5) and 17.57% (LPD-18), and the average maximum plasma concentrations (Cmax) was increased by 33.5% (LPD-5) and 26.3% (LPD-18) compared with their respective age-matched controls. The average mean retention time was approximately 114% (LPD-5) and 17.4% (LPD-18) higher than their respective age-matched controls, whereas the clearance rate (Cl/F) and volume distribution (Vz/F) of the drug were significantly lower. Consequently, there was a 68.5% (ND-5) and 4.73% (ND-18) prolongation in the mean half-life of APAP.\u0000 Conclusion The altered pharmacokinetics may arise from the intricate interplay of dietary and age influences on physiology, protein binding, and cytochrome P450enzyme activity/expression. However, the exact reason requires further investigation for a better understanding of vulnerable populations.","PeriodicalId":40092,"journal":{"name":"Journal of Health and Allied Sciences NU","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Health and Allied Sciences NU
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