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Awareness of Basic Life Support among Speech and Hearing Professionals 言语和听力专业人员的基本生命支持意识
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-08-10 DOI: 10.1055/s-0043-1772199
A. Suman, A. Neupane, Arpita Singha Chowdhury
Abstract Introduction  One of the most important aspects of happiness is one's health. Increased industrialization in developing nations has contributed to a change in disease patterns away from infectious illness as the major cause of morbidity and mortality toward chronic diseases such as heart disease and trauma. Most emergency circumstances need immediate medical attention before a person is taken to the hospital; therefore, public awareness and training programs can aid in providing efficient basic life support care and services. Only a few works of literature on basic life support and prehospital emergency care in an Indian context are available and are usually studied among school teachers. However, no comparable research including allied health experts such as speech and hearing professionals has yet been published in the literature. Aim  The present study aimed at exploring the awareness of speech and hearing professionals regarding basic life support in an Indian context. Methods  The questionnaire consisted of two sections where section A comprised 6 questions related to demographic details and participant's experience, and section B composed of 17 questions related to knowledge of normal bodily physiology, medical emergencies, and first aid and related aspects. A cross-sectional exploratory study design was conducted on 250 participants. Out of 250 responses, 42 of them were incomplete and so were removed from the study. Therefore, a total of 208 complete responses received from the participants in the age range of 22 to 60 years from across 23 states and 1 union territory of India were included in the study. Results  The result revealed a low percentage of speech and hearing professionals with an adequate understanding of basic life support. The majority of them were found to have insufficient knowledge of normal bodily physiology, medical emergencies, and first aid and related aspects. Discussion  Being the first of its kind, the present study revealed limited awareness about basic life support among professionals, and therefore, the need to improvise the knowledge of basic life support and prehospital emergency care. This may be achieved by introducing training programs of various natures and dimensions to speech and hearing professionals.
摘要简介 幸福最重要的方面之一是健康。发展中国家工业化程度的提高促使疾病模式发生了变化,从作为发病率和死亡率主要原因的传染病转变为心脏病和创伤等慢性病。在将患者送往医院之前,大多数紧急情况都需要立即就医;因此,公众意识和培训计划可以帮助提供有效的基本生命支持护理和服务。只有少数关于印度背景下基本生命支持和院前急救的文献可用,通常在学校教师中进行研究。然而,文献中尚未发表包括言语和听力专业人士等相关健康专家在内的可比研究。目标 本研究旨在探讨言语和听力专业人员在印度背景下对基本生命支持的认识。方法 问卷由两部分组成,其中A部分包括6个与人口统计细节和参与者经历有关的问题,B部分包括17个与正常身体生理学、医疗紧急情况、急救和相关方面知识有关的问题。对250名参与者进行了横断面探索性研究设计。在250份回复中,有42份是不完整的,因此被从研究中删除。因此,来自印度23个邦和1个联邦直辖区的22至60岁参与者共收到208份完整的回复。后果 结果显示,对基本生命支持有充分了解的言语和听力专业人员比例较低。他们中的大多数人对正常身体生理、医疗紧急情况、急救和相关方面的知识不足。讨论 作为同类研究中的第一项,本研究揭示了专业人员对基本生命支持的认识有限,因此需要即兴掌握基本生命支持和院前急救的知识。这可以通过向言语和听力专业人员引入各种性质和维度的培训计划来实现。
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引用次数: 0
Analysis of the Anatomical Variations in Sylvian Fissure Using MRI 应用MRI分析西尔维娅裂的解剖变异
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-08-08 DOI: 10.1055/s-0043-1772198
Kevin N. Aranha, Mahesh Mijar, Malathi Bhat
Abstract Background  The most common surgical approach in neurosurgery to diagnose and treat tumors and aneurysms is the transylvian-pterional approach. The classification of Sylvian fissure (SF) was proposed based on pure anatomical observations by Yasargil. The SF is the most identifiable feature of the superolateral brain surface, which divides the parietal and frontal lobes from the temporal lobe which lies below. Aim  The aim was to identify the anatomical variations in SF (bilaterally) in the normal population and to identify its morphological asymmetry. Setting and Design  This was a retrospective, observational descriptive record-based study which was done to identify the anatomical variations and morphological asymmetry in SF (bilaterally) in the normal healthy population using a 1.5-T magnetic resonance imaging (MRI) system. Materials and Methods  The SF was classified into five types. The categorization of the SF was done by MRI, either using T1-weighted images in three planes. Statistical Analysis  Percentage and frequency using SPSS 23.0. Results  In this study, we found that type 4 was most common in the general population of 100 patients. We found type 1 was most common in age groups above 50 up to 60 years of age. Types 2 and 4 SF were found in all age groups. Bilateral presentation of the SF can be considered as symmetric in 85% of the general population and asymmetric in 15% of the population considered in this study. Conclusion  Classification of the SF types on MRI was shown to be reliable and practicable. Sound knowledge of SF anatomy before neurosurgery can help reduce procedure-related morbidity, ischemic lesions, or edema.
背景在神经外科中诊断和治疗肿瘤和动脉瘤最常见的手术入路是经外侧-翼点入路。Sylvian裂隙(SF)的分类是由Yasargil根据纯粹的解剖观察提出的。SF是大脑上外侧表面最易识别的特征,它将顶叶和额叶与位于下方的颞叶分开。目的探讨正常人群SF(双侧)的解剖变异及其形态不对称性。背景和设计:本研究采用1.5 t磁共振成像(MRI)系统,对正常健康人群SF(双侧)的解剖变异和形态不对称性进行回顾性、观察性、描述性记录研究。材料与方法将SF分为5类。通过MRI对SF进行分类,在三个平面上使用t1加权图像。统计分析采用SPSS 23.0统计软件。结果在本研究中,我们发现4型在100例患者的一般人群中最为常见。我们发现1型在50岁到60岁以上的年龄组中最常见。2型和4型SF在所有年龄组均有发现。在本研究中,85%的一般人群中SF的双侧表现为对称,15%的人群中SF的双侧表现为不对称。结论MRI对SF分型可靠、实用。神经外科手术前对SF解剖的充分了解有助于减少手术相关的发病率、缺血性病变或水肿。
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引用次数: 0
Role of Genetic Markers in Dental Caries: A Literature Review 遗传标记在龋病中的作用:文献综述
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-31 DOI: 10.1055/s-0043-1771387
Disha Sharma, S. Bhandary
Abstract Introduction  This article reviews the literature on the role of genetic markers in the initiation and progression of dental caries and provides a modern understanding of the disease etiology. Dental caries is a complex, chronic, multifactorial disease which is influenced by genetic, environmental, and social factors. Identification of genetic risk factors will help screen and identify susceptible patients to better understand the contribution of genes in caries etiopathogenesis to formulate various diagnostic and novel therapeutic approaches in the management of the disease. Materials and Methods  Innovations and ideas were retrieved based on the literature in journals and textbooks indexed in PubMed, Google Scholar, Scopus, and Web of Science database. The theories obtained are then summarized into a continuous series; thus, readers can more easily understand the ideas and innovations offered. Results Through interactions of the involved gene products, genetic markers have been constructed and provide us with insights into the molecular mechanisms underlying caries. There can also be gene–gene interactions or gene–environment interactions that create epigenetic effects that all possibly contribute to caries risk and resistance. A variety of caries markers have been identified, including genes affecting salivary flow rates and composition, tooth formation genes, as well as immune genes. Conclusion  Information derived from various diverse studies will provide new tools to target individuals and/or populations for a more efficient and effective implementation of new preventive measures and diagnostic and novel therapeutic approaches in the management of dental caries.
摘要简介 本文综述了遗传标记在龋齿发生和发展中的作用的文献,并提供了对疾病病因的现代理解。龋齿是一种复杂、慢性、多因素的疾病,受遗传、环境和社会因素的影响。遗传风险因素的识别将有助于筛选和识别易感患者,更好地了解基因在龋齿发病中的作用,从而制定各种诊断和新的治疗方法来治疗该疾病。材料和方法 创新和想法是根据PubMed、Google Scholar、Scopus和Web of Science数据库中索引的期刊和教科书中的文献检索的。然后将所获得的理论总结为一个连续的系列;因此,读者可以更容易地理解所提供的思想和创新。结果通过相关基因产物的相互作用,构建了遗传标记,为我们深入了解龋齿的分子机制提供了依据。也可能存在基因-基因相互作用或基因-环境相互作用,产生表观遗传效应,所有这些都可能导致龋齿风险和耐药性。已经鉴定出多种龋齿标志物,包括影响唾液流速和成分的基因、牙齿形成基因以及免疫基因。结论 来自各种不同研究的信息将为针对个人和/或人群提供新的工具,以便在龋齿管理中更有效地实施新的预防措施以及诊断和治疗方法。
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引用次数: 0
Reality Faced by Dental Students during COVID-19 Pandemic Situation 新冠肺炎疫情期间牙科学生面临的现实
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-28 DOI: 10.1055/s-0043-1770961
T. Bhosale, Roshni Mathew, A. Hegde
Abstract The COVID-19 pandemic was causing an unfavorable effect on the education and mental health of students. Much information about this virus is available, but its effect on mental health has been overlooked during this pandemic. Also, disruption in the academic year had led to more of virtual learning. The pros and cons of virtual learning need to be assessed, there is a need to evaluate whether there has been a shift in approach toward dental practice. So in our survey, we evaluated the mental health, efficiency of virtual learning, and attitude toward future dental practices among dental students during the COVID-19 pandemic. Objectives  The aim of this study was to evaluate the mental health, efficiency of virtual learning, and attitude toward future dental practices among dental students during the COVID-19 pandemic. Materials and Methods  In this study, we included 87 final-year dental undergraduate students from A B Shetty Memorial Institute of Dental Sciences (ABSMIDS). The study was conducted through online questionnaire using google link. Results  In our survey, we found that many of the student's mental health was affected as they experienced certain level of depression, isolation, and mood swings, which affected their sleeping pattern. So we can consider counseling sessions for the students. We also found that virtual learning is a convenient alternative, but it also has some drawbacks as it caused physical discomforts like eye strain, back pain, etc. The students' responses were overwhelmingly positive with regard to future dental practices, but they felt there is a need to treat patients with protective equipment and guidance. Conclusions  Our study showed that this pandemic had hampered the mental health status of students in some ways. Also, it showed that virtual learning is helpful and is a convenient alternative, but it has some drawbacks as it causes physical discomforts. The students' responses were overwhelmingly positive with regard to future dental practices, but they need to treat patients with protective equipment. The Covid pandemic waves had made it difficult to control the situation, which resulted in extended periods of lockdown. Hence, these factors should be considered for the benefit of students in order to manage any future outbreaks in a better way.
新冠肺炎疫情对学生的教育和心理健康造成了不利影响。关于这种病毒的信息很多,但在这次大流行期间,人们忽视了它对精神健康的影响。此外,学年的中断导致了更多的虚拟学习。需要对虚拟学习的利弊进行评估,有必要评估牙科实践的方法是否发生了转变。因此,在我们的调查中,我们评估了2019冠状病毒病大流行期间牙科学生的心理健康状况、虚拟学习的效率以及对未来牙科实践的态度。目的本研究旨在评估2019冠状病毒病大流行期间牙科学生的心理健康状况、虚拟学习效率和对未来牙科实践的态度。材料与方法在本研究中,我们纳入了来自AB谢蒂纪念牙科科学研究所(ABSMIDS)的87名牙科本科生。本研究通过谷歌链接进行在线问卷调查。在我们的调查中,我们发现许多学生的心理健康受到了影响,因为他们经历了一定程度的抑郁、孤立和情绪波动,这影响了他们的睡眠模式。所以我们可以考虑为学生提供心理咨询。我们还发现,虚拟学习是一种方便的选择,但它也有一些缺点,因为它会导致身体不适,如眼睛疲劳,背部疼痛等。对于未来的牙科实践,学生们的反应是压倒性的积极,但他们觉得有必要用防护设备和指导来治疗病人。结论本次疫情在一定程度上影响了学生的心理健康状况。此外,该研究还表明,虚拟学习是一种有益的、方便的替代方法,但它也有一些缺点,因为它会导致身体不适。对于未来的牙科治疗,学生们的反应是压倒性的积极,但他们需要用防护设备来治疗病人。新冠肺炎大流行浪潮使局势难以控制,导致封锁时间延长。因此,为了学生的利益,应考虑这些因素,以便更好地管理未来的任何疫情。
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引用次数: 0
Will Earmuffs Improve Neonate Behavior in The Neonatal Intensive Care Unit? 耳罩能改善新生儿在重症监护室的行为吗?
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-26 DOI: 10.1055/s-0043-1771401
Sujatha R. Kannappan, Tirikhumla Chang, Jeevitha Alva
Abstract Background  Modern advanced technologies in the neonatal intensive care unit (NICU) have created more noise sources of varying frequencies and intensities, increasing the risk of hearing loss in infants. This study aimed to determine the effect of earmuffs on neonatal behavior. Materials and Methods  This study was conducted in the 13-bed level III-A NICU of a 1,000-bed tertiary care teaching hospital. Preexperimental, one-group pretest, posttest design was adopted in the study. Twenty-seven neonates were selected using nonprobability and purposive sampling techniques. The noise level was checked using a dosimeter (sound level meter SL-4030), the baseline variables were collected, and earmuffs were applied to the neonates for 2 hours in the morning and 2 hours in the evening for 3 consecutive days. An observational checklist was used to assess neonatal behavior. Results  The mean age in days was 2.19 ± 0.96, the mean weight in kilograms was 2.92 ± 0.43, and the mean gestational week was 37.56 ± 1.50. The mean sound level in the NICU was 56.7 + 14, which was higher than the NICU's recommended noise level. The most noise-generating events and equipment found in NICU were human-made noise and ventilator bubbling sounds. There was a significant difference in the mean behavioral score among neonates using earmuffs, as the “ p -value was < 0.05.” However, there was no association between pretest neonatal behavior with baseline data ( p  > 0.05). Conclusions  This study revealed that wearing earmuffs had a beneficial impact on enhancing newborn behavior.
背景现代新生儿重症监护病房(NICU)的先进技术产生了更多不同频率和强度的噪声源,增加了婴儿听力损失的风险。本研究旨在确定耳罩对新生儿行为的影响。材料与方法本研究在某拥有1000张床位的三级教学医院的13张床位的III-A级新生儿重症监护室进行。本研究采用前实验、一组前测试、后测试设计。采用非概率和目的性抽样技术选取27例新生儿。使用剂量计(声级计SL-4030)检查噪声水平,收集基线变量,并连续3天给新生儿戴上耳罩,早晚各2小时。观察性检查表用于评估新生儿行为。结果平均年龄2.19±0.96天,平均体重2.92±0.43公斤,平均妊娠周37.56±1.50周。NICU平均声级为56.7 + 14,高于NICU推荐声级。在新生儿重症监护室中发现的产生噪音最多的事件和设备是人为噪音和呼吸机鼓泡声。使用耳罩的新生儿的平均行为评分差异有统计学意义(p值为0.05)。结论:本研究表明,戴耳罩对提高新生儿行为有有益的影响。
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引用次数: 0
Mental Well-being Among Adolescents: A Cross-Sectional Survey 青少年心理健康:一项横断面调查
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-26 DOI: 10.1055/s-0043-1771384
Lavina Rodrigues, A. Safeekh, Jacintha Veigas
Abstract Background  Adolescent mental well-being is a concern for health care specialists as the prevalence of mental health issues appears to peak in this age group. Aim  Our aim was to determine the level of mental well-being among adolescents. Methods  The study was conducted using the descriptive survey approach among 720 adolescents of 16 to 17 years. Baseline proforma and the Warwick–Edinburgh Mental Well-being Scale were the tools used to collect the data. Results  Almost three-fourth of adolescents had good mental well-being, whereas 2.08% experienced poor mental well-being. The chi-square test showed a significant association between mental well-being and selected demographic variables such as stream under study ( p  = 0.001), type of family ( p  = 0.006), area of residence ( p  = 0.001), educational status of the father ( p  = 0.011), and occupational status of the father ( p  = 0.001). Conclusion  Appropriate interventions by health care professionals are needed to focus on submerged risky behaviors and obstacles to promote mental well-being among adolescents.
青少年心理健康是卫生保健专家关注的问题,因为心理健康问题的患病率似乎在这个年龄组达到顶峰。目的我们的目的是确定青少年的心理健康水平。方法采用描述性调查法对720名16 ~ 17岁青少年进行调查。基线形式表和沃里克-爱丁堡心理健康量表是收集数据的工具。结果近四分之三的青少年心理健康状况良好,2.08%的青少年心理健康状况不佳。卡方检验显示,心理幸福感与选定的人口统计学变量(如研究的学科(p = 0.001)、家庭类型(p = 0.006)、居住地区(p = 0.001)、父亲的教育程度(p = 0.011)和父亲的职业状况(p = 0.001)之间存在显著关联。结论需要卫生保健专业人员采取适当的干预措施,重点关注潜在危险行为和障碍,以促进青少年的心理健康。
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引用次数: 0
Well-Being and Resilience among Undergraduate Students at a Selected University 某高校本科生的幸福感与适应力
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-18 DOI: 10.1055/s-0043-1770069
V. Vineesha, Renita Flavia Monteiro, Viji Prasad
Abstract Introduction : Today's students of healthcare professional courses are the pillars of future healthcare delivery system. Research studies have found that they are affected with psychological disorders. Objectives  The objectives of the study were to assess the levels of well-being, resilience, and its relationship. Materials and Methods  A descriptive correlational research design was adopted to assess the well-being and resilience among undergraduate students. A total of 135 participants studying in all levels of Bachelor of Medicine and Bachelor of Surgery (MBBS), Bachelor of Dental Surgery (BDS), Bachelor of Physiotherapy (BPT), Bachelor of Science in Nursing (B.Sc Nursing), and Bachelor of Pharmacy (B.Pharm) were selected by disproportionate stratified random sampling technique. The tools used for data collection were demographic Proforma, Connor Davidson Resilience Scale, and positive emotion, engagement, relationships, meaning, and accomplishment (PERMA) scale. The reliability of the tool was tested by using Cronbach's alpha formula that was found to have a score of 0.925 for Connor Davidson Resilience Scale and a score of 0.916 for PERMA Scale. Pilot study was conducted to find out the feasibility of the study. Statistical Analysis  The data were analyzed by descriptive and inferential statistics using SPSS version 20.0. Results  The mean well-being and resilience of the study participants were 160.34 and 73.67, respectively. Majority (49.6%) had normal level of well-being and greater resilience (77%). The correlation was 0.237 and it was statistically significant ( p  < 0.05). Conclusion  There was an association between level of well-being and selected demographic variables such as age, education, level of study, religion, and residence, whereas level of resilience had significant association with education, religion, and socioeconomic status. Students' resilience can be promoted by implementing educational strategies and creating a supportive environment.
摘要简介:今天的医疗保健专业课程学生是未来医疗保健提供系统的支柱。研究发现他们有心理障碍。目标 这项研究的目的是评估幸福感、恢复力及其关系的水平。材料和方法 采用描述性相关研究设计来评估本科生的幸福感和恢复力。共有135名参与者通过不成比例的分层随机抽样技术选择了医学学士和外科学士(MBBS)、牙科外科学士(BDS)、物理治疗学士(BPT)、护理理学学士(B.Sc Nursing)和药学学士(B.Pharm)。用于数据收集的工具是人口统计形式表、康纳·戴维森弹性量表和积极情绪、参与、关系、意义和成就(PERMA)量表。该工具的可靠性通过使用Cronbachα公式进行测试,发现Connor Davidson弹性量表的得分为0.925,PERMA量表的分数为0.916。进行了初步研究,以查明该研究的可行性。统计分析 数据采用SPSS 20.0版进行描述性和推断统计学分析。后果 研究参与者的平均幸福感和恢复力分别为160.34和73.67。大多数人(49.6%)的幸福感水平正常,恢复力更强(77%)。相关系数为0.237,具有统计学意义(p < 0.05)。结论 幸福水平与选定的人口变量(如年龄、教育程度、学习水平、宗教和居住地)之间存在关联,而韧性水平与教育、宗教和社会经济地位之间存在显著关联。可以通过实施教育策略和创造支持性环境来提高学生的适应力。
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引用次数: 0
Effectiveness of Hyperbaric Oxygen Therapy in the Management of Osteoradionecrosis of the Jaw: A Systematic Review 高压氧治疗治疗颌骨放射性骨坏死的有效性:系统综述
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-07-12 DOI: 10.1055/s-0043-1770981
R. Mohandas, Subhashree Mohapatra, Rutuja Narkhede, S. Kheur
Abstract Osteoradionecrosis (ORN) of the jaws is the most dangerous long-term side effect of head and neck radiation therapy that can significantly affect the quality of life of the patients. In ORN of the jaw, the bone within the radiation field becomes devitalized and gets exposed via the overlying skin or mucosa, which remains unhealed. Hyperbaric oxygen therapy (HBOT) is used as an adjunctive therapy along with surgical debridement for the management of ORN of the jaws. HBOT promotes angiogenesis, neovascularization, fibroblast and osteoblast proliferation, and collagen production. However, the benefit of HBOT in improving the healing of tissues in patients with ORN remains controversial because of low evidence. The present systematic review aimed to compare the available data on the efficacy of HBOT on the healing of ORN of the jaw. Databases like PubMed, Scopus, Cochrane, Science Direct, Lilac, and Web of Science were searched without any date filter to obtain the relevant articles. A total of six articles met the eligibility criteria and were further processed for data extraction. Two retrospective studies observed that HBOT combined with surgical debridement promoted wound healing in patients with early stages of ORN of the jaws. Similarly, a prospective study reported that prophylactic HBOT reduced the risk of the development of ORN of the jaws following surgery to irradiated jaws. In contrast, three randomized controlled trials (RCTs) reported that HBOT did not improve the healing outcome of patients with advanced lesions of ORN of the jaws. Based on the scope of this review, we concluded that the routine use of HBOT for the prevention or management of ORN of the jaws is not recommended. Adjunctive HBOT may be considered in patients who have failed conservative therapy and subsequent surgical resection and are regarded to be at high risk.
颌骨放射性骨坏死(osteradionecrosis, ORN)是头颈部放射治疗中最危险的长期副作用,严重影响患者的生活质量。在下颚的ORN中,辐射场内的骨骼变得失活,并通过覆盖的皮肤或粘膜暴露出来,这些皮肤或粘膜仍未愈合。高压氧治疗(HBOT)作为辅助治疗与手术清创一起用于治疗颌骨的ORN。HBOT促进血管生成、新血管形成、成纤维细胞和成骨细胞增殖以及胶原蛋白的产生。然而,由于证据不足,HBOT在改善ORN患者组织愈合方面的益处仍然存在争议。本系统综述旨在比较HBOT对颌骨ORN愈合效果的现有数据。检索PubMed、Scopus、Cochrane、Science Direct、Lilac和Web of Science等数据库,不使用任何日期过滤来获取相关文章。共有6篇文章符合入选标准,并对其进行进一步处理以提取数据。两项回顾性研究发现,HBOT联合手术清创促进了早期颌骨ORN患者的伤口愈合。同样,一项前瞻性研究报道,预防性HBOT降低了放射颌骨手术后颌骨发生ORN的风险。相比之下,三个随机对照试验(rct)报道HBOT并没有改善颌骨ORN晚期病变患者的愈合结果。基于本综述的范围,我们得出结论,不推荐常规使用HBOT来预防或治疗颌骨的ORN。对于保守治疗和手术切除失败的高危患者,可以考虑辅助HBOT。
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引用次数: 0
Drug Reprofiling: A Prospective Approach to Battle Chronic Ailments 药物重组:对抗慢性病的前瞻性方法
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-06-20 DOI: 10.1055/s-0043-1769903
N. Aggarwal, S. M. Sindhoor, N. Naveen, B. Gowthami, P. Biju
Abstract The concept of drug “reprofiling” has garnered attention in the recent past post the outbreak of coronavirus disease 2019 when traditional drug discovery seemed to fail. Even though repurposing is called pharma-friendly in terms of monetary relief, clinical trials play an integral role in repurposed nontarget /combination moieties. Nevertheless, when a drug exhibits no returns to the market, an exhaustive study on mechanism of action (MOA) can help for reprofiling of drugs for new indications. However, several papers have claimed that scarcity of resources and data access, and staffing issues, tends to pull down reprofiling of drugs. In contrast to this notion, a total of 155 patented articles to date give a strong base for drug repurposing. In the present review, a scientific prospection of reprofiled antifungal and antiviral agents for the past decade was made using the PubMed database wherein a total of 410 and 768 publications have resulted respectively. The authors have attempted to focus their attention to repurposing antifungal drugs for chronic ailments and infectious diseases by understanding their MOA. For example, antifungal azoles, which work by blocking ergosterol synthesis, can be repurposed as they inhibit histone deacetylase as well significantly decrease the production of cytokines and modulate the inflammatory pathways used by cancer cells. Hence, we believe that the mentioned Food and Drug Administration-approved drug candidates can be utilized to treat nontarget diseases, notably rare/neglected diseases as well as chronic illnesses and the more recent viral infections that are spreading globally.
摘要药物“再加工”的概念在2019冠状病毒病爆发后的最近一段时间里引起了人们的关注,当时传统的药物发现似乎失败了。尽管就货币减免而言,重新调整用途被称为对制药有利,但临床试验在重新调整用途的非靶点/组合部分发挥着不可或缺的作用。然而,当一种药物在市场上没有回报时,对作用机制(MOA)进行详尽的研究有助于为新适应症重新规划药物。然而,几篇论文声称,资源和数据访问的稀缺,以及人员配备问题,往往会导致药物的重新备案。与此相反,迄今为止共有155篇专利文章为药物再利用奠定了坚实的基础。在本综述中,使用PubMed数据库对过去十年中重新应用的抗真菌和抗病毒药物进行了科学展望,其中分别发表了410篇和768篇出版物。作者试图通过了解抗真菌药物的MOA,将注意力集中在将抗真菌药物重新用于慢性病和传染病上。例如,通过阻断麦角固醇合成发挥作用的抗真菌唑类药物可以被重新利用,因为它们抑制组蛋白脱乙酰酶,并显著减少细胞因子的产生,调节癌症细胞使用的炎症途径。因此,我们认为,上述美国食品药品监督管理局批准的候选药物可用于治疗非靶向疾病,尤其是罕见/被忽视的疾病、慢性病和最近在全球传播的病毒感染。
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引用次数: 0
Association between Kinesiophobia, Anxiety, and Chronic Neck Pain among Computer Programmers in Bangalore 班加罗尔计算机程序员运动恐惧症、焦虑症和慢性颈痛的相关性
IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-06-20 DOI: 10.1055/s-0043-1770072
Kamakshi Ghaie, Milan Anand
Abstract Background  Owing to progress in information and communication technology, use of computers has been increased in developed nations. Neck discomfort is known to have psychological effect that makes daily life challenging and contributes toward persistence. To create an effective, reliable rehabilitation plan and improve the existing protocols available for the patients, the proposed study attempted to address the subject of the association between kinesiophobia, anxiety, and chronic neck pain. Objective  The aim of this study was to find the association between kinesiophobia, anxiety, and severe neck pain among computer programmers. Method  After getting the consent, 388 subjects based on selection criteria were recruited from various information technology industries in Bangalore. Then, the subjects underwent a check for neck pain using Nordic Musculoskeletal questionnaires that were divided into case and control groups, respectively. Subjects were thereafter assessed for kinesiophobia and anxiety using Tampa Scale of Kinesiophobia and Penn State Worry Questionnaire, respectively. Descriptive and inferential statistics were used for the collected data using SPSS software. Results  Out of 388 participants, the neck pain prevalence was found to be 68.80%. The result shows that the mean and standard deviation for kinesiophobia and anxiety score was 43.47 ± 16.132 and 47.15 ± 22.799 for case group, respectively, whereas for control group, it was 22.40 ± 6.470 and 21.92 ± 9.656, respectively. Significant association between kinesiophobia anxiety and long-term neck pain in computer programmers that shows p-value less than 0.05 was detected with chi-squared test. Conclusion  There was positive association seen in kinesiophobia and anxiety among computer programmers with persistent neck pain.
背景由于信息和通信技术的进步,计算机的使用在发达国家有所增加。众所周知,颈部不适会产生心理影响,使日常生活充满挑战,并有助于坚持不懈。为了制定一个有效、可靠的康复计划,并改进现有的治疗方案,本研究试图探讨运动恐惧症、焦虑和慢性颈部疼痛之间的关系。目的本研究的目的是发现在计算机程序员中运动恐惧症、焦虑和严重颈部疼痛之间的联系。方法征得同意后,按照选择标准从班加罗尔各信息技术行业招募388名受试者。然后,受试者使用北欧肌肉骨骼调查问卷进行颈部疼痛检查,这些调查问卷分别被分为病例组和对照组。随后分别使用坦帕运动恐惧症量表和宾夕法尼亚州立大学焦虑问卷对受试者进行运动恐惧症和焦虑的评估。采用SPSS软件对收集的数据进行描述性统计和推断性统计。结果388名参与者中,颈痛患病率为68.80%。结果显示,病例组运动恐惧症和焦虑得分的平均值和标准差分别为43.47±16.132和47.15±22.799,而对照组的平均值和标准差分别为22.40±6.470和21.92±9.656。通过卡方检验,发现运动恐惧症焦虑与计算机程序员长期颈部疼痛存在显著相关,p值小于0.05。结论计算机程序员持续性颈痛患者的运动恐惧症与焦虑存在正相关。
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引用次数: 0
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Journal of Health and Allied Sciences NU
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