Heart failure (HF) with low left ventricular ejection fraction (LVEF) is a disease with an unfavorable prognosis, for the treatment of which there is a need to search for drugs that improve patients’ quality of life. Such a group of drugs is inhibitors of sodium-glucose cotransporter type 2 (iSGLT-2). Purpose of the study: to assess the efficacy and safety of the new class of antihyperglycemic drugs — iSGLT-2.
{"title":"Review of the efficacy and safety of SGLT2 inhibitors in heart failure patients with low left ventricular ejection fraction without diabetes mellitus","authors":"E. V. Lomakin","doi":"10.33920/med-03-2209-08","DOIUrl":"https://doi.org/10.33920/med-03-2209-08","url":null,"abstract":"Heart failure (HF) with low left ventricular ejection fraction (LVEF) is a disease with an unfavorable prognosis, for the treatment of which there is a need to search for drugs that improve patients’ quality of life. Such a group of drugs is inhibitors of sodium-glucose cotransporter type 2 (iSGLT-2). Purpose of the study: to assess the efficacy and safety of the new class of antihyperglycemic drugs — iSGLT-2.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122001972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Bibik, A. Myazina, K. Frolov, V. Dotsenko, S. Krivokolysko
In clinical practice, the occurrence of such a side effect as gastrotoxicity can occur in patients taking NSAIDs with any route of administration. In this case, damage not only to the upper parts of the digestive tract is noted, but also to the intestine as a whole, since NSAID-induced enteropathy is manifested by the intestinal permeability disorder with protein exudation and diapedesis of erythrocytes, as well as by the development of erosions, ulcers, and life-threatening complications: bleeding, perforation, intestinal obstruction, and the appearance of circular folds [1]. The purpose of the study: to investigate the morphofunctional state of the stomach after exposure to non-steroidal anti-inflammatory drugs and novel heterocyclic compounds synthesized by us which have been proven to have high analgesic activity in white rats.
{"title":"Impact of new 1,4‑dihydrothiopyridine derivatives with analgesic activity on gastric mucosa","authors":"E. Bibik, A. Myazina, K. Frolov, V. Dotsenko, S. Krivokolysko","doi":"10.33920/med-03-2209-04","DOIUrl":"https://doi.org/10.33920/med-03-2209-04","url":null,"abstract":"In clinical practice, the occurrence of such a side effect as gastrotoxicity can occur in patients taking NSAIDs with any route of administration. In this case, damage not only to the upper parts of the digestive tract is noted, but also to the intestine as a whole, since NSAID-induced enteropathy is manifested by the intestinal permeability disorder with protein exudation and diapedesis of erythrocytes, as well as by the development of erosions, ulcers, and life-threatening complications: bleeding, perforation, intestinal obstruction, and the appearance of circular folds [1]. The purpose of the study: to investigate the morphofunctional state of the stomach after exposure to non-steroidal anti-inflammatory drugs and novel heterocyclic compounds synthesized by us which have been proven to have high analgesic activity in white rats.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128391717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. S. Lukoyanova, E. A. Khanina, M. N. Muravitskaya
Purpose of the study: to investigate the features of adherence to antihypertensive therapy at the outpatient stage.
研究目的:探讨门诊阶段降压治疗的依从性特点。
{"title":"Comparative analysis of adherence to antihypertensive therapy","authors":"A. S. Lukoyanova, E. A. Khanina, M. N. Muravitskaya","doi":"10.33920/med-03-2209-09","DOIUrl":"https://doi.org/10.33920/med-03-2209-09","url":null,"abstract":"Purpose of the study: to investigate the features of adherence to antihypertensive therapy at the outpatient stage.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"29 42","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120836054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. V. Nalyotov, O. S. Nalyotova, M. M. Alesinskiy, I. A. Korovka, E. N. Nalyotova, T. Tverdokhleb
The paper presents a pharmacoeconomic assessment of treatment costs and cost-effectiveness when using various options for antihypertensive pharmacotherapy (AHPT) in patients with hypertension. Purpose of the study: to conduct a comparative pharmacoeconomic analysis of the standard antihypertensive pharmacotherapy and the therapy including quercetin or dihydroquercetin, in patients with hypertension
{"title":"Pharmacoeconomic aspects of various options for antihypertensive pharmacotherapy in patients with hypertension","authors":"S. V. Nalyotov, O. S. Nalyotova, M. M. Alesinskiy, I. A. Korovka, E. N. Nalyotova, T. Tverdokhleb","doi":"10.33920/med-03-2209-05","DOIUrl":"https://doi.org/10.33920/med-03-2209-05","url":null,"abstract":"The paper presents a pharmacoeconomic assessment of treatment costs and cost-effectiveness when using various options for antihypertensive pharmacotherapy (AHPT) in patients with hypertension. Purpose of the study: to conduct a comparative pharmacoeconomic analysis of the standard antihypertensive pharmacotherapy and the therapy including quercetin or dihydroquercetin, in patients with hypertension","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"293 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133692982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitamins are a group of low-molecular-weight organic compounds that have a pronounced biological activity. They regulate the physiological processes that form the basis of physical performance, and functions associated with energy exchange.
{"title":"Antioxidant vitamins in oncological practice","authors":"T. Abakumova, E. G. Aleksandrova, A. Titarenko","doi":"10.33920/med-03-2209-15","DOIUrl":"https://doi.org/10.33920/med-03-2209-15","url":null,"abstract":"Vitamins are a group of low-molecular-weight organic compounds that have a pronounced biological activity. They regulate the physiological processes that form the basis of physical performance, and functions associated with energy exchange.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132959144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose of the study: to evaluate the pharmacological activity of 1,3‑diethylbenzimidazolium triiodide in the treatment of chronic compensated tonsillopharyngitis.
本研究目的:评价1,3 -二乙基苯并咪唑治疗慢性代偿性扁桃体咽炎的药理活性。
{"title":"On pharmacotherapy of chronic tonsillopharyngitis","authors":"E. K. Meloyan","doi":"10.33920/med-03-2209-11","DOIUrl":"https://doi.org/10.33920/med-03-2209-11","url":null,"abstract":"Purpose of the study: to evaluate the pharmacological activity of 1,3‑diethylbenzimidazolium triiodide in the treatment of chronic compensated tonsillopharyngitis.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121266971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Depression is a mental disorder manifested by depressed mood, cognitive and motor retardation, and suicidal ideas. In the modern world, the number of cases of a combination of mental and somatic pathologies is increasing in medical practice. Therefore, the issue of studying and correctly prescribing antidepressants is crucial. It is necessary that the drug should not only treat the mental illness of the patient, but also should not harm his/her physical health. Nialamide belongs to antidepressants, the mechanism of which is non-selective and irreversible inhibition of MAO-A and MAO-B.
{"title":"Nialamide in the treatment of depressive states","authors":"M. A. Mashkovskaya, M. Maksimov","doi":"10.33920/med-03-2209-03","DOIUrl":"https://doi.org/10.33920/med-03-2209-03","url":null,"abstract":"Depression is a mental disorder manifested by depressed mood, cognitive and motor retardation, and suicidal ideas. In the modern world, the number of cases of a combination of mental and somatic pathologies is increasing in medical practice. Therefore, the issue of studying and correctly prescribing antidepressants is crucial. It is necessary that the drug should not only treat the mental illness of the patient, but also should not harm his/her physical health. Nialamide belongs to antidepressants, the mechanism of which is non-selective and irreversible inhibition of MAO-A and MAO-B.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123185107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manifestations of mental maladaptation play an important role in diagnosing the consequences of stressful situations, and methods of their treatment include a wide range of therapeutic interventions. This paper describes a randomized placebo-controlled study of the efficacy and tolerability of the drug glycine based on a pharmaceutical composition of microencapsulated glycine and magnesium stearate in adjustment disorder with a predominance of disturbances in other emotions. In the glycine group, 82.4 % of patients achieved a significant improvement in the CGI score, while in the placebo group, this figure was 14.3 %. Glycine was safe and well tolerated by patients, none of the patients was prematurely excluded due to adverse events. The results of the study confirm the effectiveness of glycine and its superiority over placebo in this sample of patients with an improvement in all measured parameters.
{"title":"Glycine application in the treatment of patients with adjustment Disorders","authors":"V. V. Lagutkina, M. Maksimov","doi":"10.33920/med-03-2209-06","DOIUrl":"https://doi.org/10.33920/med-03-2209-06","url":null,"abstract":"Manifestations of mental maladaptation play an important role in diagnosing the consequences of stressful situations, and methods of their treatment include a wide range of therapeutic interventions. This paper describes a randomized placebo-controlled study of the efficacy and tolerability of the drug glycine based on a pharmaceutical composition of microencapsulated glycine and magnesium stearate in adjustment disorder with a predominance of disturbances in other emotions. In the glycine group, 82.4 % of patients achieved a significant improvement in the CGI score, while in the placebo group, this figure was 14.3 %. Glycine was safe and well tolerated by patients, none of the patients was prematurely excluded due to adverse events. The results of the study confirm the effectiveness of glycine and its superiority over placebo in this sample of patients with an improvement in all measured parameters.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"213 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134454584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arterial hypertension is the main factor in the progression of CKD of any etiology; therefore, effective antihypertensive therapy is a crucial task of healthcare practice. In this work, the authors aim to study the comparative effectiveness of various types of combined antihypertensive therapy in patients with different blood pressure salt sensitivity.
{"title":"Clinical efficacy of combination therapy of arterial hypertension in patients with chronic glomerulonephritis with different blood pressure salt sensitivity","authors":"A. Babkin, T. V. Malykh","doi":"10.33920/med-03-2208-12","DOIUrl":"https://doi.org/10.33920/med-03-2208-12","url":null,"abstract":"Arterial hypertension is the main factor in the progression of CKD of any etiology; therefore, effective antihypertensive therapy is a crucial task of healthcare practice. In this work, the authors aim to study the comparative effectiveness of various types of combined antihypertensive therapy in patients with different blood pressure salt sensitivity.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129082598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Maksimov, A. A. Zvegintseva, A. I. Malykhina, Y. Yashkov, A. Shikaleva
Based on the definition of obesity as a chronic, recurrent disease characterized by excessive deposition of adipose tissue in the body, it is obvious and understandable that the effectiveness of treatment is low, when in 95% of cases, it is not possible to reduce body weight for a long-term period, and a significant part of patients tend to return to initial body weight already in the first year after cessation of therapy. When all diets, psychotherapy and other attempts, including drug treatment, do not bring a special positive result, bariatric surgery methods come to the doctor and the patient’s aid. To date, bariatric surgery has been recognized as the most effective and radical method of treating morbid obesity. Bariatric surgery can lead to impressive results in terms of weight loss and improved health outcomes for patients. This type of surgery has become widespread today, and the number of operations and specialists in this field is growing every year.
{"title":"Bariatric surgery is an effective method of fighting morbid obesity","authors":"M. Maksimov, A. A. Zvegintseva, A. I. Malykhina, Y. Yashkov, A. Shikaleva","doi":"10.33920/med-03-2208-09","DOIUrl":"https://doi.org/10.33920/med-03-2208-09","url":null,"abstract":"Based on the definition of obesity as a chronic, recurrent disease characterized by excessive deposition of adipose tissue in the body, it is obvious and understandable that the effectiveness of treatment is low, when in 95% of cases, it is not possible to reduce body weight for a long-term period, and a significant part of patients tend to return to initial body weight already in the first year after cessation of therapy. When all diets, psychotherapy and other attempts, including drug treatment, do not bring a special positive result, bariatric surgery methods come to the doctor and the patient’s aid. To date, bariatric surgery has been recognized as the most effective and radical method of treating morbid obesity. Bariatric surgery can lead to impressive results in terms of weight loss and improved health outcomes for patients. This type of surgery has become widespread today, and the number of operations and specialists in this field is growing every year.","PeriodicalId":406478,"journal":{"name":"Glavvrač (Chief Medical Officer)","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131389329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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