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Advances in nanocarrier-based nose-to-brain drug delivery systems for neurological disorders - A comprehensive review 基于纳米载体的鼻-脑给药系统治疗神经系统疾病的研究进展
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-05-01 Epub Date: 2026-02-08 DOI: 10.1016/j.powtec.2026.122244
Hesam Kamyab , Sajad Jamalpour , Elham Khalili , Saravanan Rajendran
One promising technology to address the limitations of conventional drug delivery for central nervous system (CNS) disorders is the nose-to-brain drug delivery system. The anatomical advantages of the nasal route, which enable direct transport of therapeutics from the nasal cavity to the brain while bypassing the blood-brain barrier, underpin the growing interest in this innovative approach. This review emphasizes the significance of the nasal cavity's structural features, particularly its rich vascularization and high permeability, which facilitate rapid drug absorption and a swift onset of action, making it a viable pathway for neurological treatments. It also examines the roles of various nanocarriers, such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, lipid nanocapsules, cubosomes, nanoemulsions, nanogels, exosomes, gold nanoparticles, magnetic nanoparticles, quantum dots, and mesoporous silica nanoparticles, in enhancing drug delivery efficiency and targeting precision within this system. To mitigate the potential toxicity of nanoparticles to the nasal mucosa, the review discusses recent advances in formulation strategies, including surface modification, the use of advanced materials, tailoring particle characteristics, and designing novel formulations to optimize release kinetics, drug stability, and targeting specificity. These strategies aim to improve absorption while minimizing adverse effects.
鼻到脑给药系统是一种很有前途的技术,可以解决常规给药对中枢神经系统(CNS)疾病的局限性。鼻路的解剖学优势,使治疗药物从鼻腔直接运输到大脑,而绕过血脑屏障,巩固了对这种创新方法日益增长的兴趣。本文强调鼻腔的结构特点,特别是其丰富的血管化和高通透性,有利于药物的快速吸收和快速起效,使其成为神经系统治疗的可行途径。它还研究了各种纳米载体的作用,如脂质体、聚合纳米颗粒、固体脂质纳米颗粒、纳米结构脂质载体、脂质纳米胶囊、立方体体、纳米乳液、纳米凝胶、外泌体、金纳米颗粒、磁性纳米颗粒、量子点和介孔二氧化硅纳米颗粒,在提高药物递送效率和靶向精度方面。为了减轻纳米颗粒对鼻黏膜的潜在毒性,本文综述了纳米颗粒配方策略的最新进展,包括表面改性、先进材料的使用、定制颗粒特性、设计新配方以优化释放动力学、药物稳定性和靶向特异性。这些策略旨在提高吸收,同时尽量减少副作用。
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引用次数: 0
ZIF-8 derived N-doped carbon framework synergistically enhances WO3 for the photocatalytic degradation of gaseous acetaldehyde ZIF-8衍生的n掺杂碳框架协同增强WO3光催化降解气态乙醛
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1016/j.powtec.2026.122264
Beibei Cai, Shuhao Sun, Fei He
This study developed a nitrogen-doped carbon framework derived from ZIF-8 pyrolysis (NCZ8) as a novel non-metallic co-catalyst and composited it with WO3 for acetaldehyde degradation. The prepared 2% NCZ8/WO3 composite demonstrated enhanced photocatalytic performance, achieving 95.6% mineralization efficiency for acetaldehyde within 90 min under visible light irradiation, significantly higher than that of pure WO3. Characterization results revealed that the nitrogen-rich carbon framework functions through multiple synergistic mechanisms: acting as an efficient electron acceptor to promote charge separation, enhancing reactant adsorption and mass transfer through an increased BET specific surface area, and facilitating the formation of oxygen vacancies and the adsorption of light. Additionally, the photocatalytic degradation mechanism of acetaldehyde was elucidated through in situ diffuse reflectance infrared Fourier transform spectroscopy (in situ DRIFTS) and electron spin resonance (ESR) spectroscopy. This study offers a sustainable, noble-metal-free strategy for modifying WO3-based photocatalysts and deepens the understanding of the mechanistic role of MOF-derived carbon materials in the photocatalytic purification of volatile organic compounds.
本研究开发了一种由ZIF-8热解衍生的氮掺杂碳框架(NCZ8)作为新型非金属共催化剂,并与WO3复合用于乙醛降解。制备的2% NCZ8/WO3复合材料的光催化性能得到增强,在可见光照射下,90 min内对乙醛的矿化效率达到95.6%,明显高于纯WO3。表征结果表明,富氮碳骨架通过多种协同机制发挥作用:作为有效的电子受体促进电荷分离,通过增加BET比表面积增强反应物吸附和传质,促进氧空位的形成和光的吸附。此外,通过原位漫反射红外傅立叶变换光谱(in situ DRIFTS)和电子自旋共振(ESR)光谱研究了乙醛的光催化降解机理。本研究为wo3基光催化剂提供了一种可持续的、无贵金属的改性策略,加深了对mof衍生碳材料在挥发性有机化合物光催化净化中的机理作用的理解。
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引用次数: 0
Numerical study on the fine particle deposition in a squared duct bend during high-speed pneumatic conveying using the Thornton and Ning elastic-perfectly plastic adhesive particle contact model 基于Thornton和Ning弹塑性粘接颗粒接触模型的高速气力输送中细颗粒在方管弯道内沉积的数值研究
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1016/j.powtec.2026.122248
Shiguang Zhang , Hongwei Cao , Hao Chen , Quan Zhang , Huanpeng Liu
Fine particles are found to easily deposit on the wall of bends during high-speed pneumatic conveying, under which the plastic deformation is non-negligible due to critical particle–wall collisions. Therefore, this study aims to investigate the effect of plastic deformation on fine particle deposition. The Thornton and Ning (TN) elastic-perfectly plastic adhesive particle contact model, which considers the plastic deformation into particle deposition, is utilized to numerically investigate 50µm fine particle deposition in a squared duct bend (cultivation ratio equals 1.76) from Kliafas’ experiment under high bulk velocity 52.19ms−1 and 33.09ms−1. The yield stress of particles 0.25–2.0GPa is selected to represent the intensities of plastic deformation. Furthermore, the relationships between particle deposition and plastic deformation under various bulk velocities (5–55ms−1) and particle diameters (5–50µm) are discussed, respectively. The results show that the simulation achieves over 90% consistency in predicting particle velocities, over 70% in predicting particle turbulence intensities, and only 0.44% error (lowest compared to collision models from previous studies) in predicting particle free region length with Kliafas’ experiment. The simulated deposition positions show 90% of particles deposited after the bend and accumulation of deposited particles in the corner, which agrees with previous experimental studies. Results also demonstrate that higher plastic deformation critically increases deposition but shows no effect under low flow velocity (5ms−1) or small particle diameter (5µm) for the glass system. This work will benefit the understanding and application of fine particle pneumatic conveying under high conveying speed.
在高速气力输送过程中,细小颗粒容易沉积在弯道管壁上,在弯道管壁下,由于颗粒与管壁的临界碰撞而产生的塑性变形是不可忽略的。因此,本研究旨在研究塑性变形对细颗粒沉积的影响。利用Thornton和Ning (TN)弹性-完美塑性粘接颗粒接触模型,将塑性变形考虑为颗粒沉积,数值研究了Kliafas实验中在52.19ms−1和33.09ms−1高体速条件下,50µm细颗粒在方形管道弯道(培养比为1.76)内的沉积。选取0.25 ~ 2.0 gpa颗粒的屈服应力表示塑性变形强度。此外,还讨论了不同体积速度(5-55ms−1)和颗粒直径(5-50µm)下颗粒沉积与塑性变形之间的关系。结果表明,Kliafas实验预测粒子速度的一致性达到90%以上,预测粒子湍流强度的一致性达到70%以上,预测粒子自由区长度的误差仅为0.44%(与以往研究的碰撞模型相比最低)。模拟沉积位置显示,90%的颗粒在弯曲后沉积,沉积颗粒在角落堆积,这与以往的实验研究结果一致。结果还表明,较高的塑性变形会严重增加沉积,但在低流速(≤5ms−1)或小颗粒直径(≤5µm)的玻璃体系中没有影响。这项工作将有利于高输送速度下细颗粒气力输送的认识和应用。
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引用次数: 0
A novel apparatus for particle-particle single contact triboelectrification experiments 一种新型颗粒-颗粒单接触摩擦起电实验装置
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-05-01 Epub Date: 2026-02-11 DOI: 10.1016/j.powtec.2026.122259
Otome Obukohwo , Simon Jantač , Andrew Sowinski , Poupak Mehrani , Holger Grosshans
The experiment of a single contact between two sub-centimeter high-speed particles is often difficult to execute, especially if the collision must be physically and electrically isolated, as is the case for triboelectrification studies. Apparatuses designed for this type of experiment fall short of providing high-speed isolated collisions with a high probability of contact. In this article, we propose a novel apparatus that combines pneumatic conveying and acoustic levitation to provide an electrically and physically isolated, high impact speed collision between two sub-centimeter particles with a collision success rate of 93%. We can vary the pre-contact charge, material, and size of both particles, and the impact speed and angle. Test results show that triboelectrification of insulator particles is not solely driven by contact potential difference; it is a stochastic process that requires large datasets to resolve and understand. Our new apparatus can efficiently generate these datasets and provide new insights into the stochastic nature of triboelectrification, and the effect of each of the collision parameters mentioned earlier on particle-particle triboelectrification.
两个亚厘米高速粒子之间单次接触的实验通常很难进行,特别是如果碰撞必须在物理上和电上隔离,就像摩擦电气化研究的情况一样。为这类实验设计的仪器无法提供高概率接触的高速孤立碰撞。在本文中,我们提出了一种结合了气力输送和声悬浮的新型装置,可以在两个亚厘米颗粒之间提供电气和物理隔离的高冲击速度碰撞,碰撞成功率为93%。我们可以改变接触前的电荷、材料和两种颗粒的大小,以及撞击速度和角度。试验结果表明,绝缘子颗粒的摩擦起电并非完全由接触电位差驱动;这是一个随机过程,需要大量的数据集来解决和理解。我们的新设备可以有效地生成这些数据集,并为摩擦起电的随机性以及前面提到的每个碰撞参数对粒子间摩擦起电的影响提供新的见解。
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引用次数: 0
Parametric analysis of biomass combustion in a cyclone combustor using coarse-grained CFD-DEM simulation 基于粗粒度CFD-DEM模拟的旋风燃烧室生物质燃烧参数分析
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1016/j.powtec.2026.122255
Xiaolong Xing , Xiaoke Ku , Jianzhong Lin , Zhaosheng Yu
A coarse-grained computational fluid dynamics-discrete element method (CFD-DEM) model is established to investigate the influence of operating parameters on biomass combustion in a cyclone combustor. Three key parameters, i.e., operating temperature (TO), tangential inlet velocity (UT), and bottom inlet velocity (UB), are examined. Results show that increasing TO elevates the overall parcel temperature, enhances biomass consumption, and mitigates wall erosion, while the average NO and SO2 concentrations in the exhaust gas initially increase and then decrease with TO. An increase in UT raises the parcel temperature, prolongs the parcel residence time, enhances the wall parcel-hold ratio, and reduces NO concentration in the exhaust gas, but it exacerbates wall wear. As UB increases, the parcel residence time reduces and the wall parcel-hold ratio increases, whereas both average NO and SO2 concentrations in the exhaust gas first decrease and then increase, reaching minimum values at UB = 7 m/s and 8 m/s, respectively. These findings provide valuable insights into optimizing the operating conditions of biomass cyclone combustors.
建立了粗粒度计算流体力学-离散元法(CFD-DEM)模型,研究了运行参数对旋风燃烧室生物质燃烧的影响。考察了三个关键参数,即工作温度(TO)、切向进口速度(UT)和底部进口速度(UB)。结果表明:随着TO的增加,总温度升高,生物质消耗增加,壁面侵蚀减轻,废气中平均NO和SO2浓度随TO的增加先升高后降低;UT的增加使包裹温度升高,包裹停留时间延长,壁面包裹保持比增大,废气中NO浓度降低,但加剧了壁面磨损。随着UB的增大,烟气中NO和SO2的平均浓度先降低后升高,分别在UB = 7 m/s和8 m/s时达到最小值。这些发现为优化生物质旋风燃烧器的运行条件提供了有价值的见解。
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引用次数: 0
Rapid dry synthesis of nanosized potassium polytungstate via flame aerosol technology for benzene sensing 火焰气溶胶技术快速干法合成纳米多钨酸钾苯传感
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-04-15 Epub Date: 2026-02-03 DOI: 10.1016/j.powtec.2026.122238
Adrien Baut, Sebastian Kravecz, Andreas T. Güntner
Polytungstates are oxygen-linked assemblies of highly oxidized tungsten polyhedra, valued for their tunability and stability in diverse applications. Traditional synthesis methods (hydrothermal, solvothermal, solid-state) offer material variety but are limited in scalability and their ability to yield nanostructured materials due to long reaction times and high temperatures. Here, we introduce flame aerosol synthesis as a single-step, rapid and dry method to prepare K2W7O22 nanoparticulate powders and coatings. Thereby, monocrystalline and phase-pure K2W7O22 with varying crystal sizes were obtained by controlling flame temperature, residence time and metal ion concentration during particle formation by nucleation, coagulation and sintering. X-ray diffraction and electron microscopy identified the high potassium tolerance of the K2W7O22 lattice (K/W ratio up to 0.6) and phase stability up to 400 °C, before other polytungstates and WO3 polymorphs were formed, respectively. Porous films of such K2W7O22 nanoparticles featured n-type semiconductor behavior that was utilized for the chemoresistive quantification of the air pollutant benzene down to 0.2 parts-per-million at 20% relative humidity. Such sensors were quite selective over other compounds (e.g. alcohols, aldehydes, ketones, CO, NH3 or H2), in particular to chemically similar toluene and xylene (selectivity >18).
多钨酸盐是高度氧化的钨多面体的氧连接组件,因其在各种应用中的可调性和稳定性而受到重视。传统的合成方法(水热法、溶剂热法、固态法)提供了多种材料,但由于反应时间长、温度高,其可扩展性和生成纳米结构材料的能力受到限制。本文介绍了一种单步、快速、干燥的火焰气溶胶合成方法,用于制备K2W7O22纳米颗粒粉末和涂层。通过控制成核、凝聚和烧结过程中火焰温度、停留时间和金属离子浓度,可以得到不同晶粒尺寸的单晶和相纯K2W7O22。x射线衍射和电子显微镜鉴定,在形成其他多钨酸盐和WO3多晶之前,K2W7O22晶格具有较高的耐钾性(K/W比高达0.6),相稳定性高达400°C。这种k2w7022纳米颗粒的多孔膜具有n型半导体行为,用于在20%相对湿度下将空气污染物苯降至百万分之0.2的化学电阻量化。这种传感器对其他化合物(如醇、醛、酮、CO、NH3或H2),特别是对化学性质相似的甲苯和二甲苯具有很强的选择性(选择性>;18)。
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引用次数: 0
Characteristics of gas-solid two-phase flow during coalbed methane horizontal well drilling 煤层气水平井钻井气固两相流动特征
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-04-15 Epub Date: 2026-01-03 DOI: 10.1016/j.powtec.2025.122034
Jiaqi Lu, Shengyong Hu, Qianwen Xue, Guobiao Jia, Tingxu Jin
The transport of cuttings in horizontal wellbores during pneumatic drilling involves complex gas-solid two-phase flow dynamics, where insufficient cutting-carrying capacity of gas often leads to particle accumulation in horizontal sections, causing flow channel blockage. In this study, a coupled computational fluid dynamics-discrete element method (CFD-DEM) framework is employed to investigate the dynamic evolution of cuttings transport during pneumatic drilling. Key control parameters include gas injection, drill pipe rotational speed, particle diameter, and eccentricity. The results show that increasing the gas injection rate effectively suppresses cuttings accumulation, leading to a distinct nonlinear decay in the average cuttings volume fraction. Drill pipe rotation induces a helical gas flow, forming vortex structures within the gas phase field. The resulting centrifugal acceleration drives particles outward. At a rotational speed of 30 rad/min, the maximum particle velocity reaches 1.37 m/s but decreases by 37.2 % when the rotation speed increases to 40 rad/min. Drill pipe eccentricity induces asymmetric Dean vortices, causing significant particle accumulation in narrow annular gaps. At an eccentricity of e = 0.3, the cuttings volume fraction increases markedly, with an increase amplitude reaching 251.7 %. Particle diameter regulates distribution via sedimentation, inertia, and collisions, with large particle inducing flow regime transition from suspension to bed-dragged flow. A dimensionless model captures these nonlinear couplings, advancing understanding of particle transport in confined annular gas-solid flows.
在气动钻井过程中,水平井岩屑运移涉及复杂的气固两相流动动力学,气体携岩屑能力不足往往导致颗粒在水平段堆积,造成流道堵塞。本文采用计算流体动力学-离散元法(CFD-DEM)耦合框架研究了气动钻井过程中岩屑运移的动态演化。关键控制参数包括注气量、钻杆转速、颗粒直径和偏心。结果表明,增加注气量可有效抑制岩屑堆积,导致岩屑平均体积分数出现明显的非线性衰减。钻杆旋转引起螺旋气流,在气相场内形成涡流结构。由此产生的离心加速度将粒子向外驱动。转速为30 rad/min时,最大颗粒速度达到1.37 m/s,转速为40 rad/min时,最大颗粒速度下降37.2%。钻杆偏心引起了不对称的迪安涡流,在狭窄的环形空隙中造成了大量的颗粒堆积。当偏心率e = 0.3时,岩屑体积分数显著增加,增幅达251.7%。颗粒直径通过沉降、惯性和碰撞调节分布,大颗粒诱导流型由悬浮流向拖床流转变。无量纲模型捕获了这些非线性耦合,促进了对密闭环形气固流动中颗粒输运的理解。
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引用次数: 0
Study on the near-field fume diffusion characteristics of overhead welding with single weld spot on large flat wall 大型平壁单点架空焊接近场烟尘扩散特性研究
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-04-15 Epub Date: 2026-02-02 DOI: 10.1016/j.powtec.2026.122233
Xiaofen Ren , Ruixiao Yang , Erqiang Shi , Zihao Cao , Yang Yang , Xin Zhang , Jiaxing Li
Welding fumes emitted during welding processes can pose significant health risks. Most existing studies have focused on the diffusion characteristics of welding fumes in flat welding, whereas the diffusion behavior during overhead welding remains poorly understood. In this study, overhead welding of large flat walls was selected as a case to conduct both experimental and numerical investigations into welding fume diffusion patterns. By capturing the spatial diffusion trajectories of welding fumes in real time, we quantified the diffusion patterns, rates, and displacements at various welding angles. In parallel, a numerical model was developed to examine the diffusion of fume particles during overhead welding, using the particle diffusion radius as an indicator for exposure risk assessment. The results indicate that fumes generated during overhead welding primarily disperse horizontally in all directions along the large flat wall. A welding angle of 70°-90° effectively reduces horizontal fume dispersion, and at 90°, fume and particle temperatures reach ambient levels within approximately 4.0 s. Furthermore, after 20 s, the horizontal dispersion radius (Rp) of particles with a diameter of 1 μm reaches a maximum of 0.3 m, and an empirical formula relating to Rp is proposed. Through comparison with flat welding, the horizontal diffusion radius of welding fume particles in overhead welding is significantly larger, measuring 1.3 times that of flat welding. These findings provide valuable references for health risk assessments in industrial workshops and for designing fume extraction systems for overhead welding.
焊接过程中产生的焊接烟雾会对健康造成重大危害。现有的研究大多集中在平焊中焊接烟雾的扩散特性,而对架空焊接中的扩散行为了解甚少。本研究以大型平壁架空焊接为例,对焊接烟尘扩散规律进行了实验和数值研究。通过实时捕捉焊接烟雾的空间扩散轨迹,我们量化了不同焊接角度下的扩散模式、速率和位移。同时,利用粒子扩散半径作为暴露风险评估指标,建立了一个数值模型来研究架空焊接过程中烟雾粒子的扩散。结果表明:架空焊接产生的烟气主要沿大平面壁向各个方向水平扩散。70°-90°的焊接角度有效地减少了水平烟雾分散,并且在90°时,烟雾和颗粒温度在大约4.0 s内达到环境水平。此外,在20 s后,直径为1 μm的颗粒的水平弥散半径(Rp)最大达到0.3 m,并提出了与Rp相关的经验公式。与平焊相比,架空焊的焊烟颗粒水平扩散半径明显增大,为平焊的1.3倍。研究结果可为工业车间的健康风险评估和架空焊接烟尘抽吸系统的设计提供有价值的参考。
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引用次数: 0
Fingerprinting of fundamental and functional properties of natural plant and mineral powders for guiding their direct or wet-granulation tableting 天然植物和矿物粉末的基本和功能特性的指纹图谱,用于指导其直接或湿造粒压片
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-04-15 Epub Date: 2026-02-02 DOI: 10.1016/j.powtec.2026.122235
Yiting Wang , Yufei Ni , Jinzhi Li , Fei Wu , Lijie Zhao , Yanlong Hong , Lan Shen , Xiao Lin
A comprehensive evaluation was conducted on 27 directly pulverized natural medicinal plant and mineral products (DP-NPs) by analyzing their fundamental and functional characteristics. Multiple analytical methods were employed to establish different classification systems or models, as well as to investigate the influence of powder properties upon critical tablet attributes. The results indicated that: (i) The fundamental properties of DP-NPs showed considerable variation (particularly in the mineral powders), e.g., wettability (contact angle, 64.7o to 121.7o) and flowability (angle of repose, 42.2o to 63.0o); (ii) a classification system for wet-granulation suitability was established with medium and high Liquid/Solid ratio powders (e.g., leaf powders) demonstrated suitability for granulation; (iii) powders were grouped into three categories based on tableting performance: Group 2 (the best: Lycii Fructus/FR3, TS = 3.56 MPa under 240 MPa) > Group 1 (e.g., Gypsum Fibrosum) > Group 3 (the worst: Lablab Semen Album, TS = 0.01 MPa under 240 MPa) using multiple analysis; (iv) powders were categorized into three classes according to their tablet disintegration kinetics: disintegrating (e.g., root powders), expansive (e.g., leaf powders), and dissolved (FR3) ones; and (v) Elastic Net Regression modeling revealed a positive correlation between tensile strength and disintegration time of tablets for the majority of DP-NPs, identifying key variables (e.g., yield pressure) influencing the two critical quality attributes. In summary, this study provides a systematic framework for understanding and predicting the behavior of DP-NPs in tablet production, establishing a scientific foundation for rational formulation design under the Quality by Design (QbD) paradigm.
对27种直接粉碎的天然药用植物矿产品(DP-NPs)进行了综合评价,分析了其基本特性和功能特性。采用多种分析方法建立不同的分类体系或模型,考察粉末性质对片剂关键属性的影响。结果表明:(1)DP-NPs的基本性质(特别是在矿物粉末中)表现出相当大的变化,例如润湿性(接触角64.7 ~ 121.70)和流动性(休止角42.2 ~ 63.00);(ii)建立了适合湿法造粒的分类系统,其中中、高液固比粉末(如叶粉)被证明适合造粒;(iii)根据压片性能将粉末分为3组:2组(最好的是枸杞/FR3,在240 MPa下TS = 3.56 MPa)和gt; 1组(如石膏纤维)和gt; 3组(最差的是Lablab精液集,在240 MPa下TS = 0.01 MPa);(iv)粉末根据其片剂崩解动力学分为三类:崩解型(如根粉)、膨胀型(如叶粉)和溶解型(FR3);弹性网络回归模型显示,大多数DP-NPs片剂的抗拉强度与崩解时间呈正相关,确定了影响这两个关键质量属性的关键变量(如屈服压力)。综上所述,本研究为理解和预测DP-NPs在片剂生产中的行为提供了一个系统框架,为设计质量(QbD)范式下的合理处方设计奠定了科学基础。
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引用次数: 0
Particle redistribution and homogeneity in sand mixing under axial reciprocation using computed tomography 轴向往复作用下砂土混合中的颗粒重分布和均匀性
IF 4.6 2区 工程技术 Q2 ENGINEERING, CHEMICAL Pub Date : 2026-04-15 Epub Date: 2026-01-29 DOI: 10.1016/j.powtec.2026.122223
Ying Liu , Lin Feng Yu , Xu Liang , Yu Qi Jin , Yong Feng Deng , Min Liang Fei , Jie Hu , Han Ke
Particle mixing processes and homogeneity are of great significance in multiple industries, where they govern product quality and processing efficiency. To investigate the flow behavior and mixing performance of particle systems in vertical bladed mixers, Computed Tomography (CT) scanning tests were performed on samples mixed with different paddle types under a combined rotation and axial reciprocation mode, a mode widely applied in industrial mixing processes to enhance axial homogeneity. Tracer particles in the tests were reconstructed in three dimensions utilizing an image computing platform to visualize their distribution. Mixing indices, i.e., particle area ratios, inhomogeneous distribution coefficients, and fluctuation coefficients, were calculated based on an equal-area polar grid method to evaluate mixing homogeneity. The results show that, in the vertical direction, tracer particles initially located in the central region exhibited a net downward migration resulting from incomplete flow reversal, i.e., the upward paddle stroke did not fully return particles displaced downward during the preceding stroke. In the horizontal direction, the overall homogeneity of scanned cross-sections followed a three-stage trapezoidal distribution. Among the tested paddle types, 35° four-bladed paddles achieved a more homogeneous horizontal distribution. Axial reciprocation promoted vertical redistribution and particle recirculation, thereby improving horizontal homogeneity. These findings demonstrate the potential of CT-based analysis for revealing particle-scale mixing mechanisms and support the optimization of particle mixing operations.
颗粒混合过程和均匀性在许多行业中都具有重要意义,它们决定着产品质量和加工效率。为了研究垂直叶片混合器中颗粒系统的流动行为和混合性能,在旋转和轴向往复组合模式下对不同桨型混合的样品进行了计算机断层扫描(CT)测试。旋转和轴向往复组合模式广泛应用于工业混合过程中,以增强轴向均匀性。利用图像计算平台对试验中的示踪粒子进行三维重建,使其分布可视化。采用等面积极坐标网格法计算混合指标,即颗粒面积比、不均匀分布系数和波动系数,评价混合均匀性。结果表明,在垂直方向上,由于流动不完全逆转,最初位于中心区域的示踪颗粒表现出净向下迁移,即向上的桨叶行程并没有完全返回在前一行程中向下位移的颗粒。在水平方向上,扫描截面的整体均匀性遵循三级梯形分布。在试验桨叶类型中,35°四叶桨叶的水平分布更为均匀。轴向往复运动促进了垂直再分布和颗粒再循环,从而改善了水平均匀性。这些发现证明了基于ct的分析在揭示颗粒尺度混合机制和支持颗粒混合操作优化方面的潜力。
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