Pub Date : 2024-09-25DOI: 10.1038/s41569-024-01068-0
Thomas Münzel, Omar Hahad, Jos Lelieveld, Michael Aschner, Mark J. Nieuwenhuijsen, Philip J. Landrigan, Andreas Daiber
Healthy, uncontaminated soils and clean water support all life on Earth and are essential for human health. Chemical pollution of soil, water, air and food is a major environmental threat, leading to an estimated 9 million premature deaths worldwide. The Global Burden of Disease study estimated that pollution was responsible for 5.5 million deaths related to cardiovascular disease (CVD) in 2019. Robust evidence has linked multiple pollutants, including heavy metals, pesticides, dioxins and toxic synthetic chemicals, with increased risk of CVD, and some reports suggest an association between microplastic and nanoplastic particles and CVD. Pollutants in soil diminish its capacity to produce food, leading to crop impurities, malnutrition and disease, and they can seep into rivers, worsening water pollution. Deforestation, wildfires and climate change exacerbate pollution by triggering soil erosion and releasing sequestered pollutants into the air and water. Despite their varied chemical makeup, pollutants induce CVD through common pathophysiological mechanisms involving oxidative stress and inflammation. In this Review, we provide an overview of the relationship between soil and water pollution and human health and pathology, and discuss the prevalence of soil and water pollutants and how they contribute to adverse health effects, focusing on CVD.
{"title":"Soil and water pollution and cardiovascular disease","authors":"Thomas Münzel, Omar Hahad, Jos Lelieveld, Michael Aschner, Mark J. Nieuwenhuijsen, Philip J. Landrigan, Andreas Daiber","doi":"10.1038/s41569-024-01068-0","DOIUrl":"https://doi.org/10.1038/s41569-024-01068-0","url":null,"abstract":"<p>Healthy, uncontaminated soils and clean water support all life on Earth and are essential for human health. Chemical pollution of soil, water, air and food is a major environmental threat, leading to an estimated 9 million premature deaths worldwide. The Global Burden of Disease study estimated that pollution was responsible for 5.5 million deaths related to cardiovascular disease (CVD) in 2019. Robust evidence has linked multiple pollutants, including heavy metals, pesticides, dioxins and toxic synthetic chemicals, with increased risk of CVD, and some reports suggest an association between microplastic and nanoplastic particles and CVD. Pollutants in soil diminish its capacity to produce food, leading to crop impurities, malnutrition and disease, and they can seep into rivers, worsening water pollution. Deforestation, wildfires and climate change exacerbate pollution by triggering soil erosion and releasing sequestered pollutants into the air and water. Despite their varied chemical makeup, pollutants induce CVD through common pathophysiological mechanisms involving oxidative stress and inflammation. In this Review, we provide an overview of the relationship between soil and water pollution and human health and pathology, and discuss the prevalence of soil and water pollutants and how they contribute to adverse health effects, focusing on CVD.</p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"35 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-24DOI: 10.1038/s41569-024-01083-1
John C. Lin, Dang Nguyen, Anthony Zhong
John C. Lin and colleagues explore the history of racial disparities in cardiovascular outcomes and discuss the landmark findings of the CARDIA study and its contribution to the minority stress model.
John C. Lin 及其同事探讨了心血管疾病结果中种族差异的历史，并讨论了 CARDIA 研究的里程碑式发现及其对少数民族压力模型的贡献。
{"title":"Minority stress, discrimination and cardiovascular health","authors":"John C. Lin, Dang Nguyen, Anthony Zhong","doi":"10.1038/s41569-024-01083-1","DOIUrl":"https://doi.org/10.1038/s41569-024-01083-1","url":null,"abstract":"John C. Lin and colleagues explore the history of racial disparities in cardiovascular outcomes and discuss the landmark findings of the CARDIA study and its contribution to the minority stress model.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"39 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142313848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Turning back time: the promise of cardiac regeneration","authors":"Elsa Lawrence, Catherine H. Wilson","doi":"10.1038/s41569-024-01085-z","DOIUrl":"10.1038/s41569-024-01085-z","url":null,"abstract":"Elsa Lawrence and Catherine Wilson discuss the study that reported the existence of a transient regenerative window in mammals.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 12","pages":"846-846"},"PeriodicalIF":41.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-24DOI: 10.1038/s41569-024-01090-2
The 20th anniversary of Nature Reviews Cardiology comes at a time of exciting innovation for cardiovascular research and clinical cardiology, with the advent of nucleic acid-targeted therapeutics, applications of artificial intelligence, promotion of a healthy cardiovascular exposome, personalization of medicine, and recognition of the importance of diversity, equity and inclusion in health care.
{"title":"20 years of Nature Reviews Cardiology","authors":"","doi":"10.1038/s41569-024-01090-2","DOIUrl":"10.1038/s41569-024-01090-2","url":null,"abstract":"The 20th anniversary of Nature Reviews Cardiology comes at a time of exciting innovation for cardiovascular research and clinical cardiology, with the advent of nucleic acid-targeted therapeutics, applications of artificial intelligence, promotion of a healthy cardiovascular exposome, personalization of medicine, and recognition of the importance of diversity, equity and inclusion in health care.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"735-736"},"PeriodicalIF":41.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41569-024-01090-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142313849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-23DOI: 10.1038/s41569-024-01084-0
Kan Yan Chloe Li, Anne Bonnin
In this Tools of the Trade article, Li and Bonnin describe the use of cryo-X-ray phase contrast imaging to assess frozen myocardial biopsy samples.
在这篇 "贸易工具 "文章中，Li 和 Bonnin 描述了如何使用低温 X 射线相衬成像技术来评估冷冻心肌活检样本。
{"title":"Cryo-X-ray phase contrast imaging for 3D structural and molecular analysis of frozen biopsy samples","authors":"Kan Yan Chloe Li, Anne Bonnin","doi":"10.1038/s41569-024-01084-0","DOIUrl":"10.1038/s41569-024-01084-0","url":null,"abstract":"In this Tools of the Trade article, Li and Bonnin describe the use of cryo-X-ray phase contrast imaging to assess frozen myocardial biopsy samples.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 12","pages":"845-845"},"PeriodicalIF":41.7,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-20DOI: 10.1038/s41569-024-01079-x
Elizabeth E. Crouch
A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.
{"title":"The molecular landscape of vascular cells in the human brain","authors":"Elizabeth E. Crouch","doi":"10.1038/s41569-024-01079-x","DOIUrl":"10.1038/s41569-024-01079-x","url":null,"abstract":"A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 12","pages":"847-848"},"PeriodicalIF":41.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-20DOI: 10.1038/s41569-024-01072-4
Fabrizia Bonacina,Xiangyu Zhang,Nicolas Manel,Laurent Yvan-Charvet,Babak Razani,Giuseppe D Norata
Lysosomes have a central role in the disposal of extracellular and intracellular cargo and also function as metabolic sensors and signalling platforms in the immunometabolic reprogramming of macrophages and other immune cells in atherosclerosis. Lysosomes can rapidly sense the presence of nutrients within immune cells, thereby switching from catabolism of extracellular material to the recycling of intracellular cargo. Such a fine-tuned degradative response supports the generation of metabolic building blocks through effectors such as mTORC1 or TFEB. By coupling nutrients to downstream signalling and metabolism, lysosomes serve as a crucial hub for cellular function in innate and adaptive immune cells. Lysosomal dysfunction is now recognized to be a hallmark of atherogenesis. Perturbations in nutrient-sensing and signalling have profound effects on the capacity of immune cells to handle cholesterol, perform phagocytosis and efferocytosis, and limit the activation of the inflammasome and other inflammatory pathways. Strategies to improve lysosomal function hold promise as novel modulators of the immunoinflammatory response associated with atherosclerosis. In this Review, we describe the crosstalk between lysosomal biology and immune cell function and polarization, with a particular focus on cellular immunometabolic reprogramming in the context of atherosclerosis.
{"title":"Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis.","authors":"Fabrizia Bonacina,Xiangyu Zhang,Nicolas Manel,Laurent Yvan-Charvet,Babak Razani,Giuseppe D Norata","doi":"10.1038/s41569-024-01072-4","DOIUrl":"https://doi.org/10.1038/s41569-024-01072-4","url":null,"abstract":"Lysosomes have a central role in the disposal of extracellular and intracellular cargo and also function as metabolic sensors and signalling platforms in the immunometabolic reprogramming of macrophages and other immune cells in atherosclerosis. Lysosomes can rapidly sense the presence of nutrients within immune cells, thereby switching from catabolism of extracellular material to the recycling of intracellular cargo. Such a fine-tuned degradative response supports the generation of metabolic building blocks through effectors such as mTORC1 or TFEB. By coupling nutrients to downstream signalling and metabolism, lysosomes serve as a crucial hub for cellular function in innate and adaptive immune cells. Lysosomal dysfunction is now recognized to be a hallmark of atherogenesis. Perturbations in nutrient-sensing and signalling have profound effects on the capacity of immune cells to handle cholesterol, perform phagocytosis and efferocytosis, and limit the activation of the inflammasome and other inflammatory pathways. Strategies to improve lysosomal function hold promise as novel modulators of the immunoinflammatory response associated with atherosclerosis. In this Review, we describe the crosstalk between lysosomal biology and immune cell function and polarization, with a particular focus on cellular immunometabolic reprogramming in the context of atherosclerosis.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"204 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1038/s41569-024-01087-x
Irene Fernández-Ruiz
The non-steroidal mineralocorticoid receptor antagonist finerenone reduces the risk of adverse outcomes in patients with heart failure with mildly reduced ejection fraction or with preserved ejection fraction, according to findings presented at the ESC Congress 2024.
{"title":"Finerenone improves outcomes in HFmrEF and HFpEF","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01087-x","DOIUrl":"10.1038/s41569-024-01087-x","url":null,"abstract":"The non-steroidal mineralocorticoid receptor antagonist finerenone reduces the risk of adverse outcomes in patients with heart failure with mildly reduced ejection fraction or with preserved ejection fraction, according to findings presented at the ESC Congress 2024.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"739-739"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1038/s41569-024-01089-9
Irene Fernández-Ruiz
In patients with heart failure and secondary mitral valve regurgitation, transcatheter edge-to-edge repair is non-inferior to mitral valve surgery with respect to a composite of death, hospitalization for heart failure, reintervention, implantation of an assist device or stroke at 1 year after the procedure, according to findings from the MATTERHORN trial.
{"title":"TEER is non-inferior to surgery in patients with secondary mitral regurgitation","authors":"Irene Fernández-Ruiz","doi":"10.1038/s41569-024-01089-9","DOIUrl":"10.1038/s41569-024-01089-9","url":null,"abstract":"In patients with heart failure and secondary mitral valve regurgitation, transcatheter edge-to-edge repair is non-inferior to mitral valve surgery with respect to a composite of death, hospitalization for heart failure, reintervention, implantation of an assist device or stroke at 1 year after the procedure, according to findings from the MATTERHORN trial.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"742-742"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-19DOI: 10.1038/s41569-024-01080-4
Gregory B. Lim
In the NOTION-3 trial, percutaneous coronary intervention reduced the occurrence of major adverse cardiac events compared with conservative treatment in patients who were undergoing transcatheter aortic valve implantation for severe aortic stenosis and who had stable coronary artery disease.
{"title":"Combining TAVI with PCI in patients with aortic stenosis and CAD","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01080-4","DOIUrl":"10.1038/s41569-024-01080-4","url":null,"abstract":"In the NOTION-3 trial, percutaneous coronary intervention reduced the occurrence of major adverse cardiac events compared with conservative treatment in patients who were undergoing transcatheter aortic valve implantation for severe aortic stenosis and who had stable coronary artery disease.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"742-742"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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