Sensing and Bio-Sensing Research最新文献_第5页

Magnetic particle imaging using a multi-axis optically pumped magnetometer and multiple flux transformers 利用多轴光泵磁强计和多个磁通变压器进行磁粒子成像

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.sbsr.2025.100936

Teruyoshi Sasayama , Shuji Taue , Takashi Yoshida

Biofunctionalized magnetic nanoparticles (MNPs) have been widely studied for biomedical applications, including magnetic particle imaging (MPI), which is a promising diagnostic technique for cancer imaging. Because MNPs generate weak magnetic fields, highly sensitive magnetic sensors, such as optically pumped magnetometers (OPMs), are required. In our previous study, we developed an MPI scanner using an OPM and a flux transformer consisting of input and pickup coils. For rapid and accurate MNP position estimation, it is desirable to measure the magnetic field using an OPM array. OPMs that measure magnetic fields along more than two axes are commercially available. However, OPMs are expensive and difficult to array. Therefore, we propose a method for multipoint measurements using a single OPM and multiple flux transformers. In an experiment, the MNPs were magnetized using an AC magnetic field, and the resulting magnetic signals were detected using two parallel differential-type pickup coils. The detected signals were converted into magnetic fields using orthogonal input coils and measured using a dual-axis OPM. Magnetic images were obtained by scanning a diluted Resovist MNP sample with a motorized stage. The signals from each pickup coil were measured independently and simultaneously, confirming the feasibility of multipoint measurements using a single multi-axis OPM.

生物功能化磁性纳米颗粒（MNPs）在生物医学领域的应用得到了广泛的研究，包括磁颗粒成像（MPI），这是一种很有前途的癌症成像诊断技术。由于MNPs产生弱磁场，因此需要高灵敏度的磁传感器，如光泵浦磁强计（opm）。在我们之前的研究中，我们使用OPM和由输入线圈和拾取线圈组成的磁通变压器开发了MPI扫描仪。为了快速准确地估计MNP位置，需要使用OPM阵列测量磁场。沿着两个以上的轴测量磁场的opm在商业上是可用的。然而，opm既昂贵又难以排列。因此，我们提出了一种使用单个OPM和多个磁通变压器进行多点测量的方法。实验中，用交流磁场对MNPs进行磁化，并使用两个并联差分型拾取线圈检测产生的磁信号。通过正交输入线圈将检测到的信号转换成磁场，并使用双轴OPM进行测量。磁图像是通过扫描稀释的Resovist MNP样品与电动平台。来自每个拾取线圈的信号被独立地同时测量，证实了使用单个多轴OPM进行多点测量的可行性。

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引用次数: 0

Enhanced electrochemical detection of hemoglobin in chronic kidney disease (CKD) anemic patients' serum by Ni2Co(WO4)2 enriched copper nanocomposite Ni2Co(WO4)2富集铜纳米复合材料增强慢性肾脏疾病（CKD）贫血患者血清血红蛋白的电化学检测

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-02-12 DOI: 10.1016/j.sbsr.2025.100847

Kiran Batool , Faiqa Gull , Dilshad Hussain , Sana Shaheen , Fatima Hassan , Rubaida Mahmood , Muhammad Najam-ul-Haq , Batool Fatima

Anemia is associated with impaired hemoglobin (Hb) concentrations, resulting from the kidneys not producing enough erythropoietin, which leads to a decrease in red blood cells. Hemoglobin (Hb) detection is thus vital for diagnosing anemia, preventing complications, monitoring treatment efficacy, improving quality of life, and reducing morbidity rates. An electrochemical sensor based on the nickel‑cobalt bis tungstate-Cu (Ni₂Co(WO₄)₂-Cu) nanocomposite is developed using the self-combustion method to detect Hb in the blood of anemic patients. The fabricated nanocomposite is characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV–Vis), and Fourier transform infrared spectroscopy (FTIR). Sensing parameters, including scan rate, pH, concentration, and interference, are optimized. The linearity and detection limits for Ni₂Co(WO₄)₂-Cu coated onto a glassy carbon electrode (GCE) are 10–70 μM and 0.2 μM, respectively. The Hb recovery from real samples is 80–89%. The sensor stability is evaluated by 100 cyclic voltammetry (CV) cycles. Ni₂Co(WO₄)₂-Cu/GCE can efficiently monitor hemoglobin (Hb) levels in the blood of patients with chronic kidney disease (CKD). Pearson and Spearman correlation tests are used to examine the relationship between Hb and the estimated glomerular filtration rate (eGFR). This analysis reveals that Hb levels are linked to eGFR in CKD. Hb and eGFR levels in blood can thus be used as predictive biomarkers of CKD before the development of end-stage renal failure. Ni₂Co(WO₄)₂-Cu/GCE electrochemical sensor can be used in point-of-care devices and has potential applications in clinical diagnosis.

贫血与血红蛋白（Hb）浓度受损有关，由于肾脏不能产生足够的促红细胞生成素，从而导致红细胞减少。因此，血红蛋白（Hb）检测对于诊断贫血、预防并发症、监测治疗效果、提高生活质量和降低发病率至关重要。研制了一种基于镍钴铋钨酸- cu （Ni2Co(WO4)2-Cu）纳米复合材料的电化学传感器，利用自燃法检测贫血患者血液中的Hb。采用x射线衍射（XRD）、扫描电子显微镜（SEM）、紫外可见光谱（UV-Vis）和傅里叶变换红外光谱（FTIR）对制备的纳米复合材料进行了表征。传感参数，包括扫描速率，pH值，浓度和干扰，进行了优化。在玻碳电极（GCE）上涂覆Ni2Co(WO4)2-Cu的线性范围为10 ~ 70 μM，检出限为0.2 μM。实际样品的Hb回收率为80-89%。通过100次循环伏安法（CV）来评价传感器的稳定性。Ni2Co(WO4)2-Cu/GCE可有效监测慢性肾病（CKD）患者血液中血红蛋白（Hb）水平。Pearson和Spearman相关试验用于检验Hb和估计肾小球滤过率（eGFR）之间的关系。该分析揭示了慢性肾病中Hb水平与eGFR相关。因此，血液中Hb和eGFR水平可以作为终末期肾衰竭发展前CKD的预测性生物标志物。Ni2Co(WO4)2-Cu/GCE电化学传感器可用于医疗点设备，在临床诊断中具有潜在的应用前景。

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引用次数: 0

Cerium-doped SnO₂ nanoparticles as an efficient electrochemical sensor for furazolidone detection in food and biological samples 铈掺杂sno2纳米颗粒作为食品和生物样品中呋喃唑酮检测的高效电化学传感器

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-02-11 DOI: 10.1016/j.sbsr.2026.100977

E. Jegalakshmi , M. Rameshbabu , Manikandan Ayyar , S. Sasi Florence , D. Shanmugapriya , V. Mohanavel , P. Sagayaraj , Mani Govindasamy , S. Muthupandi , K. Prabha , R. Balachandran

Excessive utilization of antimicrobial agents in agricultural practices and food production results in detrimental impacts on both human wellness and environmental systems. Electrochemical detection devices serve as crucial instruments for monitoring the concentrations of these antimicrobial compounds. This research presents the fabrication of pristine and cerium-modified tin oxide nanomaterials using a straightforward co-precipitation technique for electrochemical detection purposes. The morphological and crystalline characteristics of the synthesized materials were investigated using XRD, SEM, XPS and FTIR. Among the tested compositions, tin oxide nanomaterials containing 1% cerium dopant demonstrated superior detection capabilities when compared to undoped samples and those containing 3% and 5% cerium concentrations, making it the optimal choice for cyclic voltammetry and differential pulse voltammetry investigations conducted in acidic conditions (pH 2). Furthermore, the cerium-modified tin oxide detection system exhibited excellent reproducibility, long-term stability, consistent performance, and resistance to interfering substances. Practical validation was performed using authentic biological samples including human serum, honey, and poultry tissue extracts. The cerium-enhanced tin oxide sensing platform represents an economical, user-friendly, and highly sensitive solution for antimicrobial detection, contributing significantly to advancements in sensor technology development.

在农业实践和粮食生产中过度使用抗菌剂会对人类健康和环境系统产生有害影响。电化学检测装置是监测这些抗菌化合物浓度的重要工具。本研究提出了一种用于电化学检测目的的直接共沉淀法制备原始的和铈修饰的氧化锡纳米材料。采用XRD、SEM、XPS和FTIR对合成材料的形貌和晶体特征进行了表征。在所测试的组合物中，含有1%铈掺杂的氧化锡纳米材料与未掺杂样品以及含有3%和5%铈浓度的样品相比，表现出更好的检测能力，使其成为在酸性条件下（pH 2）进行循环伏安法和差分脉冲伏安法研究的最佳选择。此外，铈修饰的氧化锡检测系统具有良好的重现性、长期稳定性、性能一致性和抗干扰性。实际验证使用真实的生物样品进行，包括人血清，蜂蜜和家禽组织提取物。铈增强氧化锡传感平台代表了一种经济、用户友好、高灵敏度的抗菌检测解决方案，为传感器技术的发展做出了重大贡献。

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引用次数: 0

Advanced nano-biosensors with multiscale applications: A comprehensive review 具有多尺度应用的先进纳米生物传感器综述

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-01-16 DOI: 10.1016/j.sbsr.2026.100965

Ayush Madan , Abdulhakim Umar Toro , Ramandeep Saini , Edward Terhemen Akange , Mehdi Rahimi

Nanobiosensors have emerged as transformative analytical platforms by integrating nanoscale materials with biological recognition to achieve ultrasensitive, selective, and real-time detection across diverse application domains. This comprehensive review critically synthesizes recent advances in nanobiosensor design through a unified multiscale framework that links nanoscale sensing mechanisms, mesoscopic device architectures, and macroscopic system integration. We systematically evaluate major nanomaterials, including carbon nanotubes, quantum dots, metallic nanoparticles, nanowires, and polymer nanocomposites, correlating their physicochemical properties with sensing performance metrics such as sensitivity, selectivity, stability, and reproducibility. Emphasis is placed on mechanistic signal transduction pathways, including electron transfer, field-effect modulation, plasmonic resonance, and fluorescence-based energy transfer, to explain observed performance trade-offs. Multiscale application pathways are analyzed across healthcare diagnostics, environmental monitoring, food safety, and agriculture, demonstrating that practical deployment depends on coordinated integration beyond nanoscale sensitivity alone. Key challenges limiting translation, including biocompatibility, fouling, fabrication scalability, and long-term signal stability, are critically assessed alongside emerging mitigation strategies such as hybrid architectures, surface engineering, and AI-assisted signal processing. By reframing multiscale nanobiosensing as a system-level design paradigm rather than a material-centric pursuit, this review provides actionable guidelines for rational sensor development and highlights future directions toward robust, scalable, and application-ready nanobiosensor technologies for global deployment.

纳米生物传感器通过将纳米材料与生物识别相结合，在不同的应用领域实现超灵敏、选择性和实时检测，已经成为变革性的分析平台。本文通过统一的多尺度框架，将纳米级传感机制、介观器件架构和宏观系统集成联系起来，对纳米生物传感器设计的最新进展进行了综合评述。我们系统地评估了主要的纳米材料，包括碳纳米管、量子点、金属纳米粒子、纳米线和聚合物纳米复合材料，将它们的物理化学性质与灵敏度、选择性、稳定性和可重复性等传感性能指标相关联。重点放在机械信号转导途径，包括电子转移，场效应调制，等离子体共振和基于荧光的能量转移，以解释观察到的性能权衡。本文分析了医疗诊断、环境监测、食品安全和农业领域的多尺度应用途径，证明了实际部署依赖于纳米级灵敏度之外的协调集成。限制转译的关键挑战，包括生物相容性、污垢、制造可扩展性和长期信号稳定性，与混合架构、表面工程和人工智能辅助信号处理等新兴缓解策略一起进行了严格评估。通过将多尺度纳米生物传感重新定义为系统级设计范式，而不是以材料为中心的追求，本综述为合理的传感器开发提供了可操作的指导方针，并强调了面向全球部署的强大、可扩展和应用就绪的纳米生物传感器技术的未来方向。

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引用次数: 0

Factorial design–assisted simultaneous electrochemical sensing of neonicotinoid pesticides using a Ni–rGO-modified electrode ni - rgo修饰电极对新烟碱类农药的析因设计辅助电化学传感

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-03-03 DOI: 10.1016/j.sbsr.2026.100992

Lueda Kulla , Ana Ameda , Petr Jakubec , Besnik Baraj , Alma Shehu , Sadik Cenolli , Nevila Broli , Majlinda Vasjari , Michal Otyepka

Neonicotinoids such as imidacloprid (IMI) and thiamethoxam (THMX), together with paraquat (PQ), are widely used agrochemicals that pose significant environmental and food safety risks due to their toxicity and persistence. Simultaneous electrochemical detection of these pesticides remains challenging because of intrinsically overlapping redox signals. Unlike conventional graphene-based electrochemical sensors that rely on peak separation, this work introduces a factorial design–assisted strategy enabling quantitative interpretation of overlapping responses and simultaneous group detection of structurally similar neonicotinoid pesticides. A chemometric-assisted electrochemical sensing approach was developed for rapid, reliable, and on-site analysis using a carbon paste electrode modified with nickel-decorated reduced graphene oxide (Ni–rGO/CPE). To the best of our knowledge, this represents one of the first application of a Ni–rGO composite combined with factorial design to quantitatively evaluate a multi-analyte pesticide system. Carbon paste electrodes served as a low-cost, versatile proof-of-concept platform. The Ni–rGO/CPE exhibited enhanced electron-transfer properties and stable electrochemical performance, confirmed by cyclic voltammetry and electrochemical impedance spectroscopy. Differential pulse voltammetry enabled detection with limits of 0.77 ppm for IMI, 1.63 ppm for THMX, and 0.70 ppm for PQ, with linear response ranges of 3–154 ppm (IMI), 4–110 ppm (THMX), and 3–119 ppm (PQ). The sensor demonstrated good reproducibility (RSD = 5.2% for IMI and 5.6% for PQ). Factorial analysis identified THMX as the dominant contributor, while PQ exhibited a suppressive interference effect, enabling quantitative interpretation of mixed-analyte responses. The method was successfully validated in river water and mandarin samples, demonstrating satisfactory accuracy and reproducibility, with recoveries of 88.5–112.6% for IMI and 76.9–108.1% for mixed solutions. This work demonstrates the potential of graphene-based nanocomposites combined with factorial design as a scalable strategy for multi-analyte pesticide detection, with further improvements achievable through integration into printed electrode systems for practical on-site monitoring.

新烟碱类如吡虫啉（IMI）和噻虫嗪（THMX）以及百草枯（PQ）是广泛使用的农用化学品，由于其毒性和持久性而构成重大的环境和食品安全风险。同时电化学检测这些农药仍然具有挑战性，因为本质上重叠的氧化还原信号。与依赖峰分离的传统石墨烯电化学传感器不同，这项工作引入了一种因子设计辅助策略，可以定量解释重叠响应并同时对结构相似的新烟碱类农药进行组检测。利用镍修饰的还原氧化石墨烯（Ni-rGO /CPE）修饰碳糊电极，开发了一种化学计量辅助电化学传感方法，用于快速、可靠和现场分析。据我们所知，这是第一次应用镍还原氧化石墨烯复合材料结合析因设计来定量评估多分析物农药系统。碳糊电极是一种低成本、多功能的概念验证平台。循环伏安法和电化学阻抗谱证实了Ni-rGO /CPE具有增强的电子转移性能和稳定的电化学性能。差分脉冲伏安法检测IMI的限限为0.77 ppm， THMX为1.63 ppm， PQ为0.70 ppm，线性响应范围为3-154 ppm (IMI), 4-110 ppm （THMX）和3-119 ppm （PQ）。该传感器具有良好的重现性（IMI RSD = 5.2%, PQ RSD = 5.6%）。析因分析发现THMX是主要因素，而PQ表现出抑制干扰效应，从而可以定量解释混合分析物的反应。该方法在河水和柑桔样品中成功验证，具有良好的准确度和重现性，IMI的回收率为88.5 ~ 112.6%，混合溶液的回收率为76.9 ~ 108.1%。这项工作证明了石墨烯基纳米复合材料结合析因设计作为一种可扩展的多分析物农药检测策略的潜力，通过集成到印刷电极系统中进行实际的现场监测，可以进一步改进。

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引用次数: 0

Innovative approaches to HER2 detection: Biosensors in breast cancer management HER2检测的创新方法：生物传感器在乳腺癌管理中的应用

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-12-20 DOI: 10.1016/j.sbsr.2025.100948

Babak Nejati , Sepideh Shadravan , Mohammad Mahdi Heidari , Atefe Etebari , Ahmad Mobed , Sajjad Jafarzadeh

Breast cancer is the most common malignancy among women globally, accounting for approximately 670,000 deaths in 2022. The overexpression of the HER2 protein in breast cancer has established it as a pivotal target for diagnostic and therapeutic strategies. Recent advancements in biosensor technology have significantly improved the detection, monitoring, and treatment of HER2-positive breast cancer. This review focuses on the latest innovations in biosensor design and functionality, including the use of nanomaterials, electrochemical, and optical biosensors, all tailored for the sensitive and specific detection of HER2. We explore not only recent advancements but also conventional methods such as FISH, CISH, and IHC, demonstrating how these approaches, in conjunction with biosensor technologies, facilitate real-time monitoring of treatment responses and disease progression, thereby offering personalized management strategies for patients. Additionally, we discuss the integration of biosensor technologies with microfluidics and wearable devices, highlighting their immense potential in point-of-care diagnostics. The novelty of this work lies in its comprehensive synthesis of current research, referencing articles published over the past two years, with a focus on biosensors specific to HER2 detection. This work particularly emphasizes multi-modal sensing approaches and their practical applications in clinical settings. By summarizing key findings and ongoing studies, this review aims to elucidate the transformative role of biosensors in enhancing breast cancer management and improving patient outcomes.

乳腺癌是全球妇女中最常见的恶性肿瘤，2022年约有67万人死于乳腺癌。乳腺癌中HER2蛋白的过表达使其成为诊断和治疗策略的关键靶点。最近生物传感器技术的进步显著改善了her2阳性乳腺癌的检测、监测和治疗。本文综述了生物传感器设计和功能的最新创新，包括纳米材料、电化学和光学生物传感器的使用，所有这些都是为灵敏和特异性检测HER2而量身定制的。我们不仅探讨了最近的进展，还探讨了传统的方法，如FISH、CISH和IHC，展示了这些方法如何与生物传感器技术相结合，促进治疗反应和疾病进展的实时监测，从而为患者提供个性化的管理策略。此外，我们还讨论了生物传感器技术与微流体和可穿戴设备的集成，强调了它们在即时诊断方面的巨大潜力。这项工作的新颖之处在于它全面综合了当前的研究，参考了过去两年发表的文章，重点是针对HER2检测的生物传感器。这项工作特别强调多模态传感方法及其在临床环境中的实际应用。通过总结主要发现和正在进行的研究，本综述旨在阐明生物传感器在加强乳腺癌管理和改善患者预后方面的变革作用。

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引用次数: 0

Realistic image-based simulations of multicellular systems exposed to electric fields for applications in impedance sensing and electrical stimulation 多细胞系统暴露于电场中的真实图像模拟，用于阻抗传感和电刺激

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2025-12-20 DOI: 10.1016/j.sbsr.2025.100950

Julius Zimmermann , Lam Vien Che , Trevor M. Kickliter , Simon Adrian , Ursula van Rienen

Advanced microscopy techniques enable live imaging of biological processes in multicellular systems with subcellular resolution. New insights into tissue–electric field interactions are unlocked by combining microscopy with microelectrodes for impedance analysis and electrical stimulation. However, a streamlined pipeline to develop realistic numerical simulations for electric field computations from imaging data is currently lacking. We present a user-friendly, automated, and efficient solution to bridge this gap. The method relies on well-established open-source software and can be readily deployed on a high-performance computing cluster. Verification cases with known analytical solutions demonstrate the high accuracy and reliability of the method. As demonstration cases of application scenarios of our method, we show how the electric field exposure of multicellular geometries imaged by 3D fluorescence microscopy can be numerically computed. Moreover, impedance spectra and the local effect of electrical stimulation by microelectrodes are computed. Finally, sensitivities to cell state and morphology are outlined, providing a basis for the rational design of future experiments.

先进的显微镜技术使多细胞系统中生物过程的实时成像具有亚细胞分辨率。通过将显微镜与微电极相结合进行阻抗分析和电刺激，解锁了组织电场相互作用的新见解。然而，目前还缺乏一种流线型的管道来根据成像数据进行电场计算的实际数值模拟。我们提出了一个用户友好、自动化和高效的解决方案来弥合这一差距。该方法依赖于完善的开源软件，可以很容易地部署在高性能计算集群上。已知解析解的验证实例表明，该方法具有较高的准确性和可靠性。作为我们方法应用场景的演示案例，我们展示了如何通过三维荧光显微镜成像多细胞几何的电场暴露可以进行数值计算。此外，还计算了微电极电刺激的阻抗谱和局部效应。最后概述了对细胞状态和形态的敏感性，为今后实验的合理设计提供了依据。

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引用次数: 0

The role of artificial intelligence and the internet of things in chitosan synthesis and electrochemical sensors applications: A brief overview 人工智能和物联网在壳聚糖合成和电化学传感器应用中的作用：综述

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-01-30 DOI: 10.1016/j.sbsr.2026.100970

Yohan , Irkham , Irwan Kurnia , Natasha Fransisca , Adisyahputra , Yeni Wahyuni Hartati

Over the past ten years, chitosan has attracted substantial scientific and industrial interest due to its natural abundance, biodegradability, and versatile functional properties. These attributes have enabled its rapid advancement across multiple sectors, including wastewater treatment, biomedical engineering, and sensor technology. Chitosan, a polysaccharide and polyelectrolyte polymer rich in amine and hydroxyl groups, offers vast potential for chemical modification. AI technologies have been utilized in chitosan synthesis for optimizing particle size, separation, coagulation, solubility, and sensor performance. Additionally, chitosan-based sensors have demonstrated efficacy in potentiometric and voltammetric applications. This review highlights the emerging roles of chitosan compound synthesis strategies for electrochemical sensors, advanced physicochemical characterization approaches, the functional role of chitosan in potentiometric and voltammetric sensing, and recent progress in integrating AI and IoT into both chitosan synthesis and chitosan-based sensor systems. A comparative analysis of recent references highlights gaps in the consistency of AI adoption and indicates a growing trend toward chitosan-based sensor development. This review provides an integrated perspective on how AI and IoT can accelerate innovation in chitosan synthesis and chitosan-based self-powered sensors, while outlining future opportunities for next-generation smart sensing and biosensing technologies.

在过去的十年中，壳聚糖因其丰富的天然资源、可生物降解性和多种功能特性而引起了科学和工业的广泛关注。这些特性使其在多个领域迅速发展，包括废水处理、生物医学工程和传感器技术。壳聚糖是一种富含胺和羟基的多糖和聚电解质聚合物，具有巨大的化学改性潜力。人工智能技术已被应用于壳聚糖的合成中，以优化粒径、分离、混凝、溶解性和传感器性能。此外，壳聚糖为基础的传感器已经证明了在电位和伏安应用的有效性。本文综述了壳聚糖复合合成策略在电化学传感器中的新作用、先进的物理化学表征方法、壳聚糖在电位和伏安传感中的功能作用，以及人工智能和物联网在壳聚糖合成和壳聚糖传感器系统中的最新进展。对最近参考文献的比较分析突出了人工智能采用一致性的差距，并表明基于壳聚糖的传感器开发的趋势日益增长。本文综述了人工智能和物联网如何加速壳聚糖合成和壳聚糖自供电传感器的创新，同时概述了下一代智能传感和生物传感技术的未来机遇。

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引用次数: 0

An active magnetic compensative cardiomagnetic measurement system based on tunneling magnetic sensors 一种基于隧道磁传感器的主动磁补偿心磁测量系统

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-01-30 DOI: 10.1016/j.sbsr.2026.100975

Guoshuo Peng , Jialin Shi , Hanxun Zhang , Qifeng Jiao , Zhenhu Jin , Jiamin Chen

This study presents the successful development of an active magnetically compensative magnetocardiogram (MCG) detection system based on tunneling magnetic resistance (TMR) sensors. The active magnetic compensation system compensates for environmental magnetic noise in real-time using a three-axis coil, ultimately reducing the environmental static magnetic field to below 60 pT, with a shielding factor on the order of 10⁶. The system has a bandwidth of 10 kHz, allowing for the suppression of wideband AC magnetic disturbances, and achieves a background noise level on the order of 10 pT. The reliable MCG signals are successfully acquired and processed by a differential TMR sensor arrangement. The experimental results demonstrate that the MCG signals acquired using the tunneling magnetoresistance (TMR) sensor exhibit clearly identifiable QRS complexes, T waves, and P waves. These features show strong consistency with those observed in both the simultaneously recorded electrocardiogram (ECG) signals and the MCG signals obtained using optically pumped magnetometers (OPMs). In conclusion, the results of this experiment demonstrate the viability and efficacy of the MCG detection system based on TMR sensors, establishing a foundation for further research and applications of the cardiac magnetic signal.

本研究成功开发了一种基于隧道磁阻（TMR）传感器的主动磁补偿心磁图（MCG）检测系统。主动磁补偿系统利用三轴线圈对环境磁噪声进行实时补偿，最终将环境静磁场降低到60pt以下，屏蔽系数为106数量级。该系统的带宽为10 kHz，可抑制宽带交流磁干扰，并实现10 pT量级的背景噪声水平。通过差分TMR传感器布置，成功获取和处理了可靠的MCG信号。实验结果表明，利用隧道磁电阻（TMR）传感器采集的MCG信号具有清晰的QRS复合物、T波和P波。这些特征与同时记录的心电图（ECG）信号和使用光泵磁强计（OPMs）获得的MCG信号所观察到的结果具有很强的一致性。综上所述，本实验结果验证了基于TMR传感器的MCG检测系统的可行性和有效性，为心脏磁信号的进一步研究和应用奠定了基础。

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引用次数: 0

Application and development of isothermal amplification and gene editing technology in cardiovascular diseases 等温扩增和基因编辑技术在心血管疾病中的应用与发展

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.sbsr.2026.100971

Jianguang Guo , Qingsong Wu , Linfeng Xie , Xiaofu Dai , Liangwan Chen

Cardiovascular disease (CVD) continues to be the leading cause of death and disability worldwide, creating a pressing need for diagnostic approaches that are rapid, sensitive, and accessible, particularly for early detection and point-of-care testing (POCT). Traditional clinical instruments, including biomarker assays and imaging modalities, are still limited by their lack of timeliness and inadequate facilitation of personalized risk assessment. Recently, nucleic acid–based biosensing has emerged as a promising strategy for cardiovascular diagnostics. Isothermal amplification methods, including loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA), enable fast and highly sensitive nucleic acid detection under constant-temperature conditions, making them well suited for portable and decentralized testing. In parallel, CRISPR/Cas-based detection systems offer programmable and sequence-specific recognition, and their integration with isothermal amplification has been experimentally shown to substantially enhance the detection of low-abundance cardiovascular nucleic acid biomarkers. Beyond diagnostics, CRISPR technologies are also being applied to mechanistic studies and gene-based therapeutic research. However, fully autonomous diagnostic–therapeutic closed-loop systems remain largely conceptual. This review summarizes current biosensing platforms and discusses their translational potential in cardiovascular precision medicine.

心血管疾病（CVD）仍然是世界范围内死亡和残疾的主要原因，迫切需要快速、敏感和可获得的诊断方法，特别是早期发现和即时检测（POCT）。传统的临床仪器，包括生物标志物分析和成像模式，仍然受到缺乏及时性和个性化风险评估的不足的限制。最近，基于核酸的生物传感已成为心血管诊断的一种有前途的策略。等温扩增方法，包括环介导等温扩增（LAMP）和重组酶聚合酶扩增（RPA），能够在恒温条件下快速、高灵敏度地检测核酸，非常适合便携式和分散检测。与此同时，基于CRISPR/ cas的检测系统提供可编程和序列特异性识别，并且它们与等温扩增的集成已被实验证明可以大大增强对低丰度心血管核酸生物标志物的检测。除了诊断之外，CRISPR技术还被应用于机制研究和基于基因的治疗研究。然而，完全自主的诊断-治疗闭环系统在很大程度上仍然是概念性的。本文综述了目前的生物传感平台，并讨论了它们在心血管精准医学中的转化潜力。

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