Sensing and Bio-Sensing Research最新文献_第7页

Detection of vaccinia virus proteins in wastewater environment using biofunctionalized optical fiber semi-distributed FBG-assisted interferometric probes 利用生物功能化光纤半分布式 FBG 辅助干涉探针检测废水环境中的疫苗病毒蛋白

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-10-23 DOI: 10.1016/j.sbsr.2024.100699

Albina Abdossova , Aina Adilzhankyzy , Kuanysh Seitkamal , Massimo Olivero , Guido Perrone , Wilfried Blanc , Luca Vangelista , Daniele Tosi

In this work, we present the detection of proteins expressed by poxvirus with fiber-optic probes based on a semi-distributed interferometer (SDI) assisted by a fiber Bragg grating (FBG), performing the measurement directly into a wastewater sample. Modern biosafety applications benefit from real-time, dynamic-sensing technologies that can perform diagnostic tasks into a wide set of analytes, with a particular emphasis on wastewater, which appears to collect a significant number of viral titers in urban and indoor environments. The SDI/FBG probe can perform substantial progress in this field, as it embeds a dual sensitivity mechanism to refractive index changes (sensitivity up to 266.1 dB/RIU (refractive index units)) that can be exploited in biosensing, while simultaneously having the capability to measure the temperature (sensitivity 9.888 pm/°C), thus providing an intrinsic cross-sensitivity compensation. In addition, a standard FBG analyzer can be used as an interrogator, improving affordability and real-time detection over previous works. The probes have been functionalized with antibodies specific for L1, A27 and A33 vaccinia virus proteins, performing detection of a protein concentration in a scenario compatible with online viral threat detection. Direct detection of wastewater samples shows that the L1-functionalized sensor has a higher response, 9.1–11.3 times higher than A33 and A27, respectively, with a maximum response of up to 1.99 dB and excellent specificity. Dynamic detection in wastewater shows that the sensors have a response over multiple detection cycles, with a sensitivity of 0.024–0.153 dB for each 10-fold increase of concentration.

在这项工作中，我们利用基于半分布式干涉仪（SDI）的光纤探针，在光纤布拉格光栅（FBG）的辅助下检测痘病毒表达的蛋白质，直接对废水样本进行测量。现代生物安全应用得益于实时、动态传感技术，这种技术可以对多种分析物执行诊断任务，尤其侧重于废水，因为废水似乎收集了城市和室内环境中大量的病毒滴度。SDI/FBG 探头可在这一领域取得重大进展，因为它具有对折射率变化的双重灵敏度机制（灵敏度高达 266.1 dB/RIU（折射率单位）），可用于生物传感，同时还具有测量温度的能力（灵敏度为 9.888 pm/°C），从而提供内在的交叉灵敏度补偿。此外，标准 FBG 分析仪可用作询问器，与以前的研究相比，提高了经济性和实时检测能力。探针已被 L1、A27 和 A33 疫苗病毒蛋白特异性抗体功能化，可在与在线病毒威胁检测兼容的情况下检测蛋白浓度。废水样本的直接检测表明，L1 功能化传感器的响应更高，分别是 A33 和 A27 的 9.1-11.3 倍，最大响应高达 1.99 分贝，特异性极佳。废水中的动态检测表明，传感器在多个检测周期内都有响应，浓度每增加 10 倍，灵敏度为 0.024-0.153 dB。

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引用次数: 0

Biosensors and biomarkers: A dynamic duo towards Alzheimer's disease detection 生物传感器和生物标记物：检测阿尔茨海默病的动态二重奏

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-10-23 DOI: 10.1016/j.sbsr.2024.100704

Jun Sung Park , Waqas Ahmad , Kyonghwan Choe , Riaz Ahmad , Tae Ju Park , Myeong Ok Kim

Alzheimer's disease is the most common and costly chronic progressive neurodegenerative disorder, with the highest global public health impact. However, diagnosing this neurodegenerative disorder is challenging and often relies on traditional clinical diagnostics techniques applied after symptoms appear, which are complex, costly, time-consuming, and potentially intrusive methods. This hinders the development of effective tools for Point-of-Care applications. To address these limitations, researchers have been developing several biosensing techniques utilizing biosensors, which have excellent selectivity and sensitivity for detecting Alzheimer's disease biomarkers at an early stage more efficiently and promptly. This comprehensive study focuses on promising biomarkers for Alzheimer's disease detection in various bio-fluids, as well as the accompanying obstacles and advantages. Furthermore, we provide a comprehensive review of current biosensing techniques, focusing on electrochemical and optical biosensors, which are well-known for their exceptional sensitivity and selectivity in detecting Alzheimer's disease biomarkers. These biosensors facilitate the early diagnosis of Alzheimer's disease in point-of-care testing, thereby enhancing point-of-care applications for Alzheimer's disease. We also explore bioelectronic tongues and bioelectronic noses as innovative, non-invasive tools for detecting biomarkers in Alzheimer's disease, which further facilitates point-of-care applications for Alzheimer's disease.

阿尔茨海默病是最常见、最昂贵的慢性进行性神经退行性疾病，对全球公共健康的影响最大。然而，诊断这种神经退行性疾病具有挑战性，通常依赖于症状出现后应用的传统临床诊断技术，这些方法复杂、昂贵、耗时，而且可能具有侵入性。这阻碍了用于护理点应用的有效工具的开发。为了解决这些局限性，研究人员利用生物传感器开发了多种生物传感技术，这些技术具有极佳的选择性和灵敏度，能更有效、更及时地在早期阶段检测阿尔茨海默病生物标志物。本综合研究侧重于各种生物流体中有望用于阿尔茨海默病检测的生物标记物，以及相应的障碍和优势。此外，我们还全面综述了当前的生物传感技术，重点介绍了电化学和光学生物传感器，它们在检测阿尔茨海默病生物标记物方面以其卓越的灵敏度和选择性而著称。这些生物传感器有助于在护理点检测中对阿尔茨海默病进行早期诊断，从而提高了阿尔茨海默病的护理点应用。我们还探索将生物电子舌和生物电子鼻作为检测阿尔茨海默病生物标志物的创新型无创工具，从而进一步促进阿尔茨海默病的护理点应用。

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引用次数: 0

Sensitive and real-time monitoring of microbial growth using a dielectric sensor with a 65-GHz LC-oscillator array and polytetrafluoroethylene membrane 使用带有 65 GHz LC 振荡器阵列和聚四氟乙烯膜的介电传感器，对微生物生长进行灵敏的实时监测

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-10-23 DOI: 10.1016/j.sbsr.2024.100703

Yoshihisa Yamashige , Siyao Chen , Yuichi Ogawa , Takashi Kawano , Shojiro Kikuchi

In this study, we report a sensitive real-time microbial growth monitoring technique using a complementary metal-oxide semiconductor (CMOS) dielectric sensor with a polytetrafluoroethylene (PTFE) membrane. The sensor comprised an LC oscillator array operating at 65-GHz, whose resonant frequency was altered according to the dielectric properties of the region approximately 15 μm from the surface. We previously reported the rapid detection of viable Escherichia coli suspended in a liquid medium using the dielectric sensor; however, sensing growing cells was challenging owing to their tendency to float outside the effective sensing area in the suspended medium. To address this, we propose a new method to enhance the sensitivity of the device using a PTFE membrane that retains cells inside the effective area during measurement. Experiments using Escherichia coli suggested that the use of the membrane more than doubled sensitivity, reducing inspection times for practical applications. Furthermore, experiments with Lactococcus lactis, Staphylococcus epidermidis, and Saccharomyces cerevisiae demonstrated that this method can be used to monitor the growth of various microbes. In addition, variations in the output values of each oscillator facilitated the determination of microbial characteristics, such as cell size and growth distribution. This microbial growth monitoring technique is expected to find applications across a wide range of fields, such as food inspection, environmental hygiene monitoring, antibiotic susceptibility testing, new drug discovery, and the exploration of beneficial microbes.

在这项研究中，我们报告了一种使用带有聚四氟乙烯（PTFE）膜的互补金属氧化物半导体（CMOS）介质传感器的灵敏实时微生物生长监测技术。该传感器由一个工作频率为 65 GHz 的 LC 振荡器阵列组成，其谐振频率根据距离表面约 15 μm 区域的介电特性而改变。我们以前曾报道过利用介电传感器快速检测悬浮在液体介质中的大肠杆菌，但由于生长中的细胞容易漂浮在悬浮介质的有效感应区域之外，因此感应生长中的细胞具有挑战性。为了解决这个问题，我们提出了一种新方法，利用聚四氟乙烯膜在测量过程中将细胞保留在有效区域内，从而提高设备的灵敏度。使用大肠杆菌进行的实验表明，使用这种膜可将灵敏度提高一倍以上，从而缩短实际应用中的检测时间。此外，使用乳酸乳球菌、表皮葡萄球菌和酿酒酵母进行的实验表明，这种方法可用于监测各种微生物的生长。此外，每个振荡器输出值的变化有助于确定微生物的特征，如细胞大小和生长分布。这种微生物生长监测技术有望在食品检验、环境卫生监测、抗生素敏感性测试、新药研发和有益微生物探索等广泛领域得到应用。

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引用次数: 0

Sensitivity Approach for Blood Glucose Impedance Data Using the Geselowitz Theorem 利用格塞洛维茨定理的血糖阻抗数据灵敏度方法

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-09-26 DOI: 10.1016/j.sbsr.2024.100698

Bruna Gabriela Pedro , John Alexander Gomez Sanchez , Pedro Bertemes-Filho

The article presents a preclinical study focused on developing a non-invasive blood glucose monitoring device. Current glucose monitoring methods, such as capillary or venous tests, are inconvenient for frequent use, making continuous monitoring challenging. This study explores the BGP (Bruna Gabriela Pedro) model, which links electrical impedance to blood glucose levels, as a potential alternative. Using the Geselowitz Theorem and impedance spectroscopy in a 4-electrode configuration, the study investigates the relationship between blood conductivity and glucose concentration. Impedance spectra were recorded for five human blood samples with glucose concentrations between 106 and 188 mg/dL. These samples were housed in an insulating container with four stainless steel electrodes. Conductivity was calculated using the Geselowitz Theorem at 1.0, 3.9, and 24.9 kHz. A finite element model built in COMSOL was employed to assess electrode sensitivity, which had a maximum regression error of 3.75 %. The results demonstrated a sigmoid relationship between blood glucose concentration and conductivity, with impedance decreasing non-linearly as glucose levels increased. Sensitivity diminished for glucose concentrations exceeding 188 mg/dL. An increase of 82 mg/dL in glucose concentration led to conductivity changes of 1.14, 2.82, and 5.14 S/m at frequencies of 1.0, 3.9, and 24.9 kHz, respectively. The findings suggest that the BGP analytical model could be refined through the inclusion of additional data on glucose's impact on electrical impedance. These improvements could support the development of non-invasive glucose meters. The research holds significant clinical potential for the creation of a simple, cost-effective glucose monitoring device. Continuous glucose monitoring could enhance diagnostic accuracy and support better therapeutic decision-making, particularly in emergency care. The affordability and accessibility of such a device may benefit a broad patient base.

文章介绍了一项临床前研究，重点是开发一种无创血糖监测设备。目前的血糖监测方法，如毛细血管或静脉测试，不方便经常使用，使得连续监测具有挑战性。本研究探讨了 BGP（Bruna Gabriela Pedro）模型，该模型将电阻抗与血糖水平联系起来，可作为一种潜在的替代方法。该研究利用格塞洛维茨定理和 4 个电极配置的阻抗谱，研究了血液电导率与葡萄糖浓度之间的关系。研究人员记录了葡萄糖浓度在 106 至 188 mg/dL 之间的五个人体血液样本的阻抗光谱。这些样本被放置在一个带有四个不锈钢电极的绝缘容器中。在 1.0、3.9 和 24.9 kHz 频率下，使用格塞洛维茨定理计算电导率。采用 COMSOL 建立的有限元模型评估电极灵敏度，其最大回归误差为 3.75%。结果表明，血糖浓度与电导率之间呈弧形关系，阻抗随血糖水平的升高而非线性下降。葡萄糖浓度超过 188 毫克/分升时，灵敏度降低。葡萄糖浓度每增加 82 毫克/分升，在频率为 1.0、3.9 和 24.9 千赫时，电导率的变化分别为 1.14、2.82 和 5.14 S/m。研究结果表明，可以通过加入更多有关葡萄糖对电阻抗影响的数据来改进 BGP 分析模型。这些改进将有助于无创血糖仪的开发。这项研究具有巨大的临床潜力，可用于制造简单、经济的葡萄糖监测设备。连续葡萄糖监测可以提高诊断的准确性，支持更好的治疗决策，特别是在急救护理中。这种设备价格低廉，使用方便，可使广大患者受益。

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引用次数: 0

A Fiber optics based surface enhanced Raman spectroscopy sensor for chemical and biological sensing 用于化学和生物传感的基于光纤的表面增强拉曼光谱传感器

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-09-24 DOI: 10.1016/j.sbsr.2024.100686

Jiayu Liu , Bohong Zhang , Amjed Abdullah , Sura A. Muhsin , Jie Huang , Mahmoud Almasri

This paper investigates an innovative surface-enhanced Raman scattering (SERS) sensor developed on a side-polished multimode optical fiber core. The optical fiber was integrated into specifically designed 3-dimensional printed mold, where manual polishing of the fiber took place. Microsphere Photolithography (MPL) techniques was employed to pattern periodic nanoantenna arrays on the polished surface, incorporating multiple disk diameters at a fixed periodicity. Subsequent gold deposition/lift-off were carried out to transfer the pattern from the photoresist to the fiber core, resulting in highly periodic hexagonal closed pack (HCP) arrays of nanodisks. These arrays can significantly enhance the SERS signal intensity compared to that of the fiber tip. The sensor's performance was demonstrated using various concentrations of Rhodamine 6G (R6G) dye ranging from 10⁻⁵ to 10⁻⁹ M as a function of disk diameter and sensing surface area. The resulting spectra revealed characteristic peak positions that aligned well with the fingerprint Raman spectra of R6G. The results demonstrates that the sensitivity is 10⁻⁹ M for the sensor with an 800 nm disk diameter.

本文研究了一种在侧面抛光的多模光纤芯上开发的创新型表面增强拉曼散射（SERS）传感器。光纤被集成到专门设计的三维印刷模具中，在模具中对光纤进行手工抛光。采用微球光刻（MPL）技术在抛光表面上绘制周期性纳米天线阵列图案，以固定的周期整合多个圆盘直径。随后进行金沉积/剥离，将图案从光刻胶转移到光纤纤芯，从而形成高度周期性的六边形封闭包（HCP）纳米盘阵列。与光纤尖端相比，这些阵列能显著增强 SERS 信号强度。利用罗丹明 6G (R6G) 染料的不同浓度（10-5 至 10-9 M），作为圆盘直径和传感表面积的函数，展示了传感器的性能。产生的光谱显示出特征峰位置，与 R6G 的指纹拉曼光谱非常吻合。结果表明，圆盘直径为 800 nm 的传感器的灵敏度为 10-9 M。

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引用次数: 0

Computational and experimental study of AC measurements performed by a double-nanohole plasmonic nanopore sensor on 20 nm silica nanoparticles 20 纳米二氧化硅纳米颗粒上的双纳米孔等离子纳米孔传感器进行交流测量的计算和实验研究

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-09-21 DOI: 10.1016/j.sbsr.2024.100694

Homayoun Asadzadeh , Scott Renkes , MinJun Kim , George Alexandrakis

A novel method of AC sensing is presented that uses a double nanohole (DNH) nanoaperture atop a solid-state nanopore (ssNP) to trap analytes and measure their optical and electrical properties. In this method analytes are propelled by an external applied voltage towards the sensor until they are trapped at the DNH-ssNP interface via a self-induced back action (SIBA) plasmonic force. We have previously named this method SIBA Actuated Nanopore Electrophoresis (SANE) sensing and have shown its ability to perform concurrent optical and DC electrical measurements. Here, we extend this method to AC sensing of 20 nm SiO₂ (silica) nanoparticles, using voltage modulation over a wide range of frequencies applied on top of a baseline DC bias. The sensor was constructed using two-beam GFIS Focused Ion Beam (FIB) lithography, incorporating Ne FIB to mill the DNH and He FIB to drill a central 30 nm ssNP. We utilized COMSOL Multiphysics simulations to explore the multi-frequency AC current conductance properties of the silica nanoparticles trapped at the SANE sensor. These simulations computed conductance changes and phase shifts induced by the presence of the nanoparticle over an AC frequency range of 20 Hz to 100 kHz. Experimental measurements confirmed the trends seen in the computational data. Additional computational studies were then performed to dissect the underlying mechanisms driving the observed AC measurements. Looking forward, we aim to adapt this technology for probing therapeutic nanoparticles non-invasively, offering a promising tool for enhancing quality control of nanoparticle-mediated drug and gene delivery systems.

本文介绍了一种新型交流传感方法，该方法在固态纳米孔（ssNP）顶端使用双纳米孔（DNH）纳米孔来捕获分析物，并测量其光学和电学特性。在这种方法中，分析物被外加电压推向传感器，直到它们通过自诱导反作用（SIBA）质子力被捕获在 DNH-ssNP 接口上。我们曾将这种方法命名为 SIBA 驱动纳米孔电泳（SANE）传感，并展示了它同时进行光学和直流电测量的能力。在这里，我们将这种方法扩展到 20 nm SiO2（二氧化硅）纳米粒子的交流传感，在基线直流偏压的基础上使用宽频率范围的电压调制。该传感器采用双光束 GFIS 聚焦离子束 (FIB) 光刻技术制造，其中 Ne FIB 用于铣削 DNH，He FIB 用于钻取中心 30 nm 的 ssNP。我们利用 COMSOL 多物理场仿真来探索 SANE 传感器上捕获的二氧化硅纳米粒子的多频率交流电流电导特性。这些模拟计算了纳米粒子的存在在 20 Hz 至 100 kHz 的交流频率范围内引起的电导变化和相移。实验测量结果证实了计算数据中的趋势。随后，我们又进行了其他计算研究，以剖析驱动观察到的交流测量结果的潜在机制。展望未来，我们的目标是将这项技术应用于非侵入性的治疗纳米粒子探测，为加强纳米粒子介导的药物和基因递送系统的质量控制提供一种前景广阔的工具。

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引用次数: 0

Analysis of plant physiological responses based on leaf color changes through the development and application of a wireless plant sensor 通过开发和应用无线植物传感器，根据叶色变化分析植物生理反应

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-09-21 DOI: 10.1016/j.sbsr.2024.100688

Kaori Kohzuma , Ko-ichiro Miyamoto

Optical sensing has been used to monitor the physiological responses of plants noninvasively and in real-time. In this study, we developed a low-cost plant sensor that performed a spectroscopic measurement at eight wavelengths in the visible region. The sensor head of the system was attached directly to the underside of the leaf, not blocking the light, and eliminating correction work because of the constant distance between the sensor head and the sample. The collected data was shared in the cloud via a network, thereby enabling remote monitoring. The characteristics of the plant sensor as a spectral photometer were validated, with major wavelengths also showing good correlations with those of a conventional spectrometer. The reflectance of 620 nm in this sensor detected plant aging indicator chlorophyll, and 550 nm detected stress indicator xanthophyll. In the field test, these plant physiological responses, seasonal leaf color changes and environmental stresses, were observed remotely. The results indicate that the novel spectroscopic measurement from the underside of the leaf is effective to realize accurate and stable measurement of the plant leaf. The plant sensor can be a powerful tool in the field of agriculture and ecological study by realizing simultaneous, multi-point and remote monitoring at a low cost.

光学传感已被用于非侵入式实时监测植物的生理反应。在这项研究中，我们开发了一种低成本植物传感器，可在可见光区域的八个波长进行光谱测量。该系统的传感器头直接贴在叶片背面，不会遮挡光线，而且由于传感器头与样本之间的距离恒定，因此无需校正工作。收集到的数据通过网络在云端共享，从而实现远程监控。植物传感器作为光谱光度计的特性得到了验证，其主要波长与传统光谱仪的波长具有良好的相关性。该传感器中 620 纳米波长的反射率可检测植物老化指标叶绿素，550 纳米波长的反射率可检测胁迫指标黄绿素。在实地测试中，这些植物生理反应、季节性叶色变化和环境胁迫都是通过远程观测到的。结果表明，这种从叶片背面进行光谱测量的新方法能有效实现对植物叶片的精确、稳定测量。该植物传感器可以低成本实现多点同步远程监测，是农业和生态研究领域的有力工具。

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引用次数: 0

An innovative eco-friendly optical sensor designed specifically to detect gallium ions in environmental samples 专为检测环境样品中镓离子而设计的创新型环保光学传感器

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-09-20 DOI: 10.1016/j.sbsr.2024.100687

Mahmood D. Aljabri , Salah M. El-Bahy , Refat El-Sayed , Khaled F. Debbabi , Alaa S. Amin , Naglaa M. Mohamed

A novel membrane optical sensor with high selectivity and sensitivity was developed for detecting ultra-low concentrations of gallium (Ga³⁺) ions. This sensor utilized a newly synthesized compound, 4,4′-1,3-pHenylene bis(azanylyli-dene) bis(methanylylidene))bis(N,N-dimethylaniline) (PBABMBD), as its ionophore, combined with 9-(diethylamino)-5-(octadecanoylimino)-5H-benzo[a] phenoxazine (ETH-5294) as a chromoionophore within a polyvinyl chloride (PVC) membrane matrix. The impact of various parameters on the fabrication of the optical sensor and its ability to detect Ga³⁺ ions was thoroughly examined and fine-tuned for optimization. Demonstrating a broad linear dynamic range from 6.25 × 10⁻⁹ to 3.75 × 10⁻⁶ M, the sensor boasts impressive detection and quantification limits of 1.75 and 6.00 × 10⁻⁹ M Ga³⁺ ions, respectively. Furthermore, the sensor demonstrates a swift response time of just 3.0 min and can undergo multiple rejuvenations with 0.25 M HNO₃ solutions. The study examined the impact of potential interfering ions on the detection of Ga³⁺ions. Fortunately, the results showed that the created optical sensor was very selective for Ga³⁺ ions and barely reacts with other anions and cations, especially indium (III). Furthermore, the sensor proved effective in accurately detecting Ga³⁺ ions across a range of samples, including food, alloys, water, and biological specimens.

为检测超低浓度的镓（Ga3+）离子，开发了一种具有高选择性和灵敏度的新型膜光学传感器。该传感器采用了一种新合成的化合物--4,4′-1,3-亚茚双(偶氮苯基)双(甲基亚茚))双(N,N-二甲基苯胺)(PBABMBD)作为其离子载体、与作为发色团的 9-（二乙基氨基）-5-（十八碳酰亚氨基）-5H-苯并[a]吩噁嗪（ETH-5294）结合，置于聚氯乙烯（PVC）膜基质中。我们深入研究了各种参数对光学传感器制造及其检测 Ga3+ 离子能力的影响，并对其进行了微调优化。该传感器具有从 6.25 × 10-9 到 3.75 × 10-6 M 的宽线性动态范围，其 Ga3+ 离子的检测和定量限分别为 1.75 和 6.00 × 10-9 M，令人印象深刻。此外，该传感器的响应时间仅为 3.0 分钟，并能在 0.25 M HNO3 溶液中多次恢复活力。研究考察了潜在干扰离子对 Ga3+ 离子检测的影响。幸运的是，研究结果表明，所创建的光学传感器对 Ga3+ 离子具有很高的选择性，几乎不会与其他阴离子和阳离子（尤其是铟（III））发生反应。此外，该传感器还能有效准确地检测各种样品中的 Ga3+ 离子，包括食品、合金、水和生物样本。

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引用次数: 0

Universal strategy for rapid design and analysis of gas detection peptide chips with positional preference 快速设计和分析具有位置偏好的气体检测肽芯片的通用策略

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-09-19 DOI: 10.1016/j.sbsr.2024.100697

Honghao Zhang , Xi Zhang , Yingjun Si , Hui Li , Jiyang Han , Chuan Yang , Hui Yang

The design and analysis of gas detection chips directly affect their detection efficiency and applicability. Detection devices are currently restricted by detection principles, facing drawbacks like intricate structural design, limited applicability, and low detection efficiency. We have designed a complete set of design and analysis scheme for a peptide gas detection chip. First, we selected specific and high-affinity peptide combinations from existing peptide-gas affinity datasets. Then, the peptide chip's arrangement was grouped according to the variations in peptides' affinity towards different gases. Peptides were arranged based on their affinity levels within each group, striking a balance between discrimination and flexibility in the design of the chip. Finally, we evaluated the analysis methods by generating simulated data based on a reference affinity matrix constructed from actual data. Due to the preprocessing role of chip design on affinity data, all methods can effectively accomplish gas classification. In gas concentration prediction tasks, our method reduced mean square error to 0.41, significantly outperforming other methods. This gas detection scheme shortens the development cycle of chip design and analysis methods, fully utilizing the specificity of peptides, enhancing gas analysis effectiveness, and demonstrating the agile development of gas detection chips.

气体检测芯片的设计和分析直接影响其检测效率和适用性。目前，检测设备受检测原理限制，存在结构设计复杂、适用性有限、检测效率低等缺点。我们设计了一套完整的多肽气体检测芯片设计和分析方案。首先，我们从现有的多肽-气体亲和性数据集中选择了特异性和高亲和性的多肽组合。然后，根据多肽对不同气体亲和力的变化对多肽芯片的排列进行分组。每组中的多肽根据其亲和力水平进行排列，从而在芯片设计的区分度和灵活性之间取得平衡。最后，我们根据实际数据构建的参考亲和力矩阵生成模拟数据，对分析方法进行了评估。由于芯片设计对亲和性数据的预处理作用，所有方法都能有效完成气体分类。在气体浓度预测任务中，我们的方法将均方误差降至 0.41，明显优于其他方法。该气体检测方案缩短了芯片设计和分析方法的开发周期，充分利用了多肽的特异性，提高了气体分析的有效性，体现了气体检测芯片的敏捷开发。

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引用次数: 0

Sediment microbial fuel cells capable of powering outdoor environmental monitoring sensors 能够为室外环境监测传感器供电的沉积物微生物燃料电池

IF 5.4 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100695

Yolina Hubenova , Ivo Bardarov , Eleonora Hubenova , Evelina Slavcheva

In this study, Sediment Microbial Fuel Cells (SMFCs) prototypes have been developed to operate under open-air conditions and power sensors for environmental monitoring. Two SMFCs with a volume of 50 l each, consisting of two types of anodic materials – graphite and coke, were operated on-field for over a year. The electrical outputs have been recorded and compared with the measured environmental parameters such as temperature, light illumination, atmospheric pressure, humidity, etc. The statistical analysis of the obtained data shows that temperature changes between 0 and 14 °C do not affect the power achieved. On the contrary, the sunlight irradiation showed a second-order polynomial correlation with the current generated by the SMFCs, increasing the latter during the days. The cathode reactions significantly impacted the power density achieved by both explored SMFCs and the system's sustainability. The metallurgical coke is suggested to be used as an inexpensive and convenient anode material for SMFCs giving compatible results to the widely used graphite.

本研究开发了沉积物微生物燃料电池（SMFC）原型，可在露天条件下运行，并为环境监测传感器供电。两个体积各为 50 升的 SMFC 由石墨和焦炭两种阳极材料组成，在现场运行了一年多。电输出已被记录下来，并与温度、光照、大气压力、湿度等测量环境参数进行了比较。对所获数据的统计分析显示，0 至 14 °C 之间的温度变化不会影响所实现的功率。相反，太阳光辐照与 SMFC 产生的电流呈二阶多项式关系，后者在日间不断增加。阴极反应对所探索的 SMFC 达到的功率密度和系统的可持续性都有很大影响。建议将冶金焦炭用作 SMFC 的廉价且方便的阳极材料，其结果与广泛使用的石墨相一致。

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