In this study, a simple, fast and sensitive voltammetric detection using boron-doped diamond (BDD) electrode was proposed for simultaneous quantification of benzene (BZ), naphthalene (NF) and anthracene (AC) from priority organic pollutants class in real tap water. The electrochemical behaviors of individual and simultaneous BZ, NF and AC studied by cyclic voltammetry (CV) on BDD electrode showed a large separation between their oxidation potential, which allowed the development of simple simultaneous detection method. Differential-pulse voltammetry (DPV) technique operated at step potential of 5 mV and modulation amplitude of 200 mV enabled to reach the lowest limits of detection of 0.40 μM for BZ, 0.04 μM for NF and 0.70 nM for AC, which is appropriate for water quality control related to their environmental quality standards. No significant influence of chloride ions was found and the method was validated in real tap water and surface water spiked with known concentrations of BZ, NF and AC, which proved the practical utility of the method for water quality control.
本研究提出了一种使用掺硼金刚石(BDD)电极的简单、快速和灵敏的伏安检测方法,用于同时定量真实自来水中优先有机污染物类别中的苯(BZ)、萘(NF)和蒽(AC)。在 BDD 电极上用循环伏安法(CV)研究了 BZ、NF 和 AC 的单独和同时电化学行为,结果表明它们的氧化电位之间存在较大的分离,这为开发简单的同时检测方法提供了条件。差分脉冲伏安(DPV)技术在 5 mV 的阶跃电位和 200 mV 的调制幅度下工作,使 BZ、NF 和 AC 的最低检测限分别为 0.40 μM、0.04 μM 和 0.70 nM,适合于与环境质量标准有关的水质控制。该方法在实际自来水和添加了已知浓度的 BZ、NF 和 AC 的地表水中没有发现明显的氯离子影响,证明了该方法在水质控制中的实用性。
{"title":"Simultaneous voltammetric detection of benzene, naphthalene and anthracene from water using boron-doped diamond electrode","authors":"Aniela Pop , Florica Manea , Anamaria Baciu , Sorina Motoc (m. Ilies)","doi":"10.1016/j.sbsr.2024.100641","DOIUrl":"https://doi.org/10.1016/j.sbsr.2024.100641","url":null,"abstract":"<div><p>In this study, a simple, fast and sensitive voltammetric detection using boron-doped diamond (BDD) electrode was proposed for simultaneous quantification of benzene (BZ), naphthalene (NF) and anthracene (AC) from priority organic pollutants class in real tap water. The electrochemical behaviors of individual and simultaneous BZ, NF and AC studied by cyclic voltammetry (CV) on BDD electrode showed a large separation between their oxidation potential, which allowed the development of simple simultaneous detection method. Differential-pulse voltammetry (DPV) technique operated at step potential of 5 mV and modulation amplitude of 200 mV enabled to reach the lowest limits of detection of 0.40 μM for BZ, 0.04 μM for NF and 0.70 nM for AC, which is appropriate for water quality control related to their environmental quality standards. No significant influence of chloride ions was found and the method was validated in real tap water and surface water spiked with known concentrations of BZ, NF and AC, which proved the practical utility of the method for water quality control.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000230/pdfft?md5=41d62b48b62becf79558e6b9870a3105&pid=1-s2.0-S2214180424000230-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.1016/j.sbsr.2024.100640
Yong Wan Cho , Ik Soo Lee , Hye-Won Lim , Young Sook Kim
A biochip assay provides high-throughput and multiplexed analysis of biological samples, chemicals, and natural products. Pruritus is itchiness due to several causes, such as allergy, dry skin, pregnancy, liver disease, kidney disease, and thyroid disease. Treatment of pruritus is associated with reduced immunoglobulin (IgE) and FcεRI levels in sera. Treatment of pruritus include corticosteroid creams or ointment. However, they have side effects, so we need a safer treatment using natural products. Here, we developed an assay using protein chip technology to identify natural products with antipruritic activity that inhibit IgE-FcεRI binding. Of the 28 tested natural product extracts, Corni Fructus extract inhibited human IgE-FcεRI binding and also showed anti-histamine effects in MC/9 mast cells. These results suggest that this protein biochip assay system can be used to identify promising natural product extracts for the treatment of pruritus.
{"title":"Human IgE-FcεRI chip assay to screen natural products for antipruritic activity","authors":"Yong Wan Cho , Ik Soo Lee , Hye-Won Lim , Young Sook Kim","doi":"10.1016/j.sbsr.2024.100640","DOIUrl":"10.1016/j.sbsr.2024.100640","url":null,"abstract":"<div><p>A biochip assay provides high-throughput and multiplexed analysis of biological samples, chemicals, and natural products. Pruritus is itchiness due to several causes, such as allergy, dry skin, pregnancy, liver disease, kidney disease, and thyroid disease. Treatment of pruritus is associated with reduced immunoglobulin (IgE) and FcεRI levels in sera. Treatment of pruritus include corticosteroid creams or ointment. However, they have side effects, so we need a safer treatment using natural products. Here, we developed an assay using protein chip technology to identify natural products with antipruritic activity that inhibit IgE-FcεRI binding. Of the 28 tested natural product extracts, Corni Fructus extract inhibited human IgE-FcεRI binding and also showed anti-histamine effects in MC/9 mast cells. These results suggest that this protein biochip assay system can be used to identify promising natural product extracts for the treatment of pruritus.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000229/pdfft?md5=6c0d1e4e8883ae34b21e965d23276d41&pid=1-s2.0-S2214180424000229-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140281371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-20DOI: 10.1016/j.sbsr.2024.100638
Alaa Kamal Yousif Dafhalla , Th.S. Dhahi , A. Wesam Al-Mufti , Sawsan Ali Saad , Abdulrahman Saad Alqahtani , Mudher Ali Hussein Al-nuaimi , Mohamed Elshaikh Elobaid , Tijjani Adam , Subash C.B. Gopinath
Nanogap nanowires have gained attention for their potential applications in biosensing due to their unique physical properties, such as high surface-to-volume ratios and enhanced sensitivity. These nanowires can be used as electrodes in electrochemical biosensors, improving the sensitivity and selectivity of these devices. They can also be integrated into sensor platforms using mature nano-fabrication procedures. These advancements offer great potential for developing highly sensitive and accurate biosensors for various applications, including biomedical diagnostics, environmental monitoring, and food safety. Nanogap nanowires have revolutionized the field by providing enhanced sensitivity and accuracy in detecting biological molecules. They have also been used in the fabrication of segmented nanowires for chemical sensing, allowing for more precise and targeted detection of specific analytes. Nanogap nanowires have shown promise in protein biomarker analysis, enabling ultra-sensitive detection of protein biomarkers at low levels. This review provides an overview of recent advancements in Nanogap Nanowires and their applications in biosensing.
{"title":"Nanogap nanowires and its applications in biosensing","authors":"Alaa Kamal Yousif Dafhalla , Th.S. Dhahi , A. Wesam Al-Mufti , Sawsan Ali Saad , Abdulrahman Saad Alqahtani , Mudher Ali Hussein Al-nuaimi , Mohamed Elshaikh Elobaid , Tijjani Adam , Subash C.B. Gopinath","doi":"10.1016/j.sbsr.2024.100638","DOIUrl":"https://doi.org/10.1016/j.sbsr.2024.100638","url":null,"abstract":"<div><p>Nanogap nanowires have gained attention for their potential applications in biosensing due to their unique physical properties, such as high surface-to-volume ratios and enhanced sensitivity. These nanowires can be used as electrodes in electrochemical biosensors, improving the sensitivity and selectivity of these devices. They can also be integrated into sensor platforms using mature nano-fabrication procedures. These advancements offer great potential for developing highly sensitive and accurate biosensors for various applications, including biomedical diagnostics, environmental monitoring, and food safety. Nanogap nanowires have revolutionized the field by providing enhanced sensitivity and accuracy in detecting biological molecules. They have also been used in the fabrication of segmented nanowires for chemical sensing, allowing for more precise and targeted detection of specific analytes. Nanogap nanowires have shown promise in protein biomarker analysis, enabling ultra-sensitive detection of protein biomarkers at low levels. This review provides an overview of recent advancements in Nanogap Nanowires and their applications in biosensing.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000205/pdfft?md5=c20707a2a4d3f5285a94cad816da1f8d&pid=1-s2.0-S2214180424000205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19DOI: 10.1016/j.sbsr.2024.100639
Rudrarup Sengupta, Heena Khand, Gabby Sarusi
Utilizing LC resonant metamaterials (MM) for terahertz (THz) impedance spectroscopy has opened new avenues for detection of biomolecules and nanoparticles. A recent revelation highlights the pivotal role of coupling between MM resonance and Fabry-Pérot (FP) oscillations of the substrate. This interaction significantly influences the observed spectral shift (), thereby enhancing the overall sensitivity. In this work, we utilize the FP-MM optical decoupling physics for sensitivity enhancement to detect bio-particles at extremely low concentrations, thereby overcoming the particle detection limit. After implementing these innovations, we discovered that this technology can be leveraged to detect and screen patients infected with the omicron variant of SARS-CoV-2 and other lung related diseases using exhaled breath from patients. Upon achieving excellent agreement between simulations and experimental spectroscopic data, we have successfully detected and screened multiple respiratory-related diseases from the exhaled breath collected on the metasurface in a breathalyzer configuration. We obtained significant even with ultra-low concentrations of bio-particles and demarcated the ranges of for different lung diseases that do no overlap and are not constrained by any limit of detection. This work reveals new prospects for diagnosis and screening of multiple respiratory-related diseases with a single and prompt breath test.
利用低电平谐振超材料(MM)进行太赫兹(THz)阻抗光谱分析为检测生物分子和纳米粒子开辟了新途径。最近的一项发现强调了 MM 共振与基底的法布里-佩罗(Fabry-Pérot,FP)振荡之间耦合的关键作用。这种相互作用极大地影响了观测到的光谱偏移(ΔF),从而提高了整体灵敏度。在这项工作中,我们利用 FP-MM 光学解耦物理学来提高灵敏度,以检测极低浓度的生物微粒,从而克服了微粒检测极限。在实现这些创新后,我们发现这项技术可用于利用患者呼出的气体来检测和筛查感染 SARS-CoV-2 奥米克变种的患者以及其他肺部相关疾病的患者。在模拟和实验光谱数据之间取得极佳的一致性之后,我们成功地在呼吸分析仪配置中从元表面收集的呼出气体中检测和筛查出多种呼吸系统相关疾病。即使生物颗粒的浓度超低,我们也能获得明显的 ΔF,并为不同肺部疾病划定了 ΔF 范围,这些范围不会重叠,也不受任何检测极限的限制。这项工作揭示了通过单一、快速的呼气测试诊断和筛查多种呼吸系统相关疾病的新前景。
{"title":"Screening and diagnosis of respiratory diseases using metamaterial based sensitive terahertz impedance spectroscopy","authors":"Rudrarup Sengupta, Heena Khand, Gabby Sarusi","doi":"10.1016/j.sbsr.2024.100639","DOIUrl":"https://doi.org/10.1016/j.sbsr.2024.100639","url":null,"abstract":"<div><p>Utilizing LC resonant metamaterials (MM) for terahertz (THz) impedance spectroscopy has opened new avenues for detection of biomolecules and nanoparticles. A recent revelation highlights the pivotal role of coupling between MM resonance and Fabry-Pérot (FP) oscillations of the substrate. This interaction significantly influences the observed spectral shift (<span><math><mi>ΔF</mi></math></span>), thereby enhancing the overall sensitivity. In this work, we utilize the FP-MM optical decoupling physics for sensitivity enhancement to detect bio-particles at extremely low concentrations, thereby overcoming the particle detection limit. After implementing these innovations, we discovered that this technology can be leveraged to detect and screen patients infected with the omicron variant of SARS-CoV-2 and other lung related diseases using exhaled breath from patients. Upon achieving excellent agreement between simulations and experimental spectroscopic data, we have successfully detected and screened multiple respiratory-related diseases from the exhaled breath collected on the metasurface in a breathalyzer configuration. We obtained significant <span><math><mi>ΔF</mi></math></span> even with ultra-low concentrations of bio-particles and demarcated the ranges of <span><math><mi>ΔF</mi></math></span> for different lung diseases that do no overlap and are not constrained by any limit of detection. This work reveals new prospects for diagnosis and screening of multiple respiratory-related diseases with a single and prompt breath test.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000217/pdfft?md5=1027b970d9a8bdd3269047ef6c4122e1&pid=1-s2.0-S2214180424000217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140187402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.sbsr.2024.100629
J.D. Aguilera , D. Arranz , A. Peña , P. Marín , M.C. Horrillo , P. de la Presa , D. Matatagui
In this paper, an innovative device with gas remote-sensing capability is proposed, which is based on the interaction between magnetic nanoparticles and gases associated with exhaled breath biomarkers that can have a metabolic origin. Magnetite (Fe₃O₄) nanoparticles of around 30 nm have been used. The gas molecules adsorbed on surface modulate the magnetization of the nanoparticles and magnetostatic surface spin waves (MSSW) propagated on an yttrium iron garnet (YIG) thin film are used to detect this modulation by the induced frequency shift. The optimization of the remote gas sensor has been carried out through simulations of a magnetic model. Simulations show the feasibility of developing a high-performance remote sensor by encapsulating the nanostructures in a polytetrafluoroethylene (PTFE) tube and detecting part per million changes in their magnetization. The results show the possibility of developing new, inexpensive, reusable, contactless magnetic gas sensors employing spin waves as transductor. The developed sensor shows a high sensitivity and selectivity to concentrations as low as 50 ppm of different breath biomarkers.
{"title":"Real-time monitoring of breath biomarkers using magnonic wireless sensor based on magnetic nanoparticles","authors":"J.D. Aguilera , D. Arranz , A. Peña , P. Marín , M.C. Horrillo , P. de la Presa , D. Matatagui","doi":"10.1016/j.sbsr.2024.100629","DOIUrl":"10.1016/j.sbsr.2024.100629","url":null,"abstract":"<div><p>In this paper, an innovative device with gas remote-sensing capability is proposed, which is based on the interaction between magnetic nanoparticles and gases associated with exhaled breath biomarkers that can have a metabolic origin. Magnetite (Fe₃O₄) nanoparticles of around 30 nm have been used. The gas molecules adsorbed on surface modulate the magnetization of the nanoparticles and magnetostatic surface spin waves (MSSW) propagated on an yttrium iron garnet (YIG) thin film are used to detect this modulation by the induced frequency shift. The optimization of the remote gas sensor has been carried out through simulations of a magnetic model. Simulations show the feasibility of developing a high-performance remote sensor by encapsulating the nanostructures in a polytetrafluoroethylene (PTFE) tube and detecting part per million changes in their magnetization. The results show the possibility of developing new, inexpensive, reusable, contactless magnetic gas sensors employing spin waves as transductor. The developed sensor shows a high sensitivity and selectivity to concentrations as low as 50 ppm of different breath biomarkers.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000114/pdfft?md5=60db8e376bfddb7b9fe62bf92822eb07&pid=1-s2.0-S2214180424000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.sbsr.2024.100635
Mehrdad Abbasi , Ali Rasi Mahmoudi , Karim Asadpour-Zeynali
An innovative three-electrode system was developed for electrochemical analysis, aiming to overcome the limitations of conventional approaches. The system incorporates a glassy carbon rod as the working electrode, platinum wire as the counter electrode, and silver wire as the quasi-reference electrode that are positioned within an epoxy resin substrate. The advantages of this type of three-electrode system include the possibility of sample analysis in both drop mode and when immersed in the solution, low manufacturing cost, reduction of chemical consumption, no need for special maintenance protocols, no requirement for stand, absence of liquid junction potential (due to the direct contact of the reference electrode with the solution), usability for on-site analysis, and usability for non-aqueous solutions.
To check the efficiency of this electrode, cyclic voltammetry technique was used. Also, for direct comparison of PTE with conventional three-electrode system and screen-printed electrode (SPE), current density was used instead of peak current. According to the results, PTE system shows more peak current for the same surface area of the working electrode compared to other systems, which shows the high efficiency of the proposed system for electrochemical analysis. Acetaminophen (ACT) was chosen in order to investigate the ability to measure an analyte with PTE using differential pulse voltammetry (DPV). The linear range was obtained from 29.12 μM to 609.37 μM with a detection limit (LOD) 20.22 μM. Also, PTE was used to measure ACT in tablet as real sample.
{"title":"Fabrication of a polishable and reusable triple electrode as a new generation of three-electrode systems for the electrochemical analysis applications through both immersion and drop casting-procedures","authors":"Mehrdad Abbasi , Ali Rasi Mahmoudi , Karim Asadpour-Zeynali","doi":"10.1016/j.sbsr.2024.100635","DOIUrl":"https://doi.org/10.1016/j.sbsr.2024.100635","url":null,"abstract":"<div><p>An innovative three-electrode system was developed for electrochemical analysis, aiming to overcome the limitations of conventional approaches. The system incorporates a glassy carbon rod as the working electrode, platinum wire as the counter electrode, and silver wire as the quasi-reference electrode that are positioned within an epoxy resin substrate. The advantages of this type of three-electrode system include the possibility of sample analysis in both drop mode and when immersed in the solution, low manufacturing cost, reduction of chemical consumption, no need for special maintenance protocols, no requirement for stand, absence of liquid junction potential (due to the direct contact of the reference electrode with the solution), usability for on-site analysis, and usability for non-aqueous solutions.</p><p>To check the efficiency of this electrode, cyclic voltammetry technique was used. Also, for direct comparison of PTE with conventional three-electrode system and screen-printed electrode (SPE), current density was used instead of peak current. According to the results, PTE system shows more peak current for the same surface area of the working electrode compared to other systems, which shows the high efficiency of the proposed system for electrochemical analysis. Acetaminophen (ACT) was chosen in order to investigate the ability to measure an analyte with PTE using differential pulse voltammetry (DPV). The linear range was obtained from 29.12 μM to 609.37 μM with a detection limit (LOD) 20.22 μM. Also, PTE was used to measure ACT in tablet as real sample.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000175/pdfft?md5=c7a40efc2b56536bbc1311380d4898e8&pid=1-s2.0-S2214180424000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140014470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.sbsr.2024.100622
Thuanny Borba Rios , Mariana Rocha Maximiano , Gabriel Cidade Feitosa , Martin Malmsten , Octávio Luiz Franco
Infectious diseases in farm animals triggered by pathogenic microorganisms affect the health and well-being of livestock and human populations. Pathogen detection is an important step for the successful diagnosis, treatment and control of infectious diseases in animals. Pathogens that persist in the poultry and livestock industries can be responsible for more than 70% of emerging infections. Thus, rapid diagnostic tools are extremely important. In recent years, nanotechnology has emerged as a great opportunity to tackle this challenge and to develop fast, accurate and economical diagnostics for the detection of pathogens. Various nanostructures, due to the presence of unique characteristics shown in nanomaterials, have already been applied in biodiagnostics to detect specific molecular targets, including pathogen detection. In this context, this review focuses on the application, role and challenges of nanosensors in detecting disease-causing pathogens in agriculture. Several nanostructures are investigated for their utility in providing innovative solutions for pathogen detection in farm animals. This comprehensive examination seeks to unravel the intricate nanosensors landscape, shedding some light on their role in advancing diagnostic capabilities within the agricultural domain. By elucidating the challenges inherent in their application, the review contributes to the ongoing discourse on harnessing nanotechnology for the detection and management of infectious diseases in livestock, ultimately paving the way for developments in veterinary diagnostics.
{"title":"Nanosensors for animal infectious disease detection","authors":"Thuanny Borba Rios , Mariana Rocha Maximiano , Gabriel Cidade Feitosa , Martin Malmsten , Octávio Luiz Franco","doi":"10.1016/j.sbsr.2024.100622","DOIUrl":"10.1016/j.sbsr.2024.100622","url":null,"abstract":"<div><p>Infectious diseases in farm animals triggered by pathogenic microorganisms affect the health and well-being of livestock and human populations. Pathogen detection is an important step for the successful diagnosis, treatment and control of infectious diseases in animals. Pathogens that persist in the poultry and livestock industries can be responsible for more than 70% of emerging infections. Thus, rapid diagnostic tools are extremely important. In recent years, nanotechnology has emerged as a great opportunity to tackle this challenge and to develop fast, accurate and economical diagnostics for the detection of pathogens. Various nanostructures, due to the presence of unique characteristics shown in nanomaterials, have already been applied in biodiagnostics to detect specific molecular targets, including pathogen detection. In this context, this review focuses on the application, role and challenges of nanosensors in detecting disease-causing pathogens in agriculture. Several nanostructures are investigated for their utility in providing innovative solutions for pathogen detection in farm animals. This comprehensive examination seeks to unravel the intricate nanosensors landscape, shedding some light on their role in advancing diagnostic capabilities within the agricultural domain. By elucidating the challenges inherent in their application, the review contributes to the ongoing discourse on harnessing nanotechnology for the detection and management of infectious diseases in livestock, ultimately paving the way for developments in veterinary diagnostics.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000047/pdfft?md5=e08ecf7d71dc02a08aaab7f342e2e26b&pid=1-s2.0-S2214180424000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139679307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The technology of surface plasmon resonance (SPR) is widely recognized and valued for its ability to rapidly and sensitively investigate biomolecular interactivities in real-time. Herein, we numerically investigate the collective influence of metal/ transition metal dichalcogenide (TMDC)/halide perovskite (HP)/2D carbon (C) and phosphorus (P) allotropes on the functionality of an SPR biosensor deploying Kretschmann configuration. The incident light wavelength is held constant at 633 nm, and radiative properties of the hybrid structure are determined using the attenuated total reflection and transfer matrix techniques. Crucial performance metrics such as quality factor (QF), figure of merit (FoM), sensitivity, and detection accuracy are calculated. The comparison is conducted and evaluated against the current literature using performance outcomes in terms of several prisms such as BK7, BAK1, BAF10, SF5, SF10, SF11, 2S2G, CaF2, and CsF, several TMDCs such as WS2, MoS2, WSe2, MoSe2, and PtSe2, several HPs such as CsPbI3, KSnI3, CsSnI3, and FASnI3, and 2D C/P allotropes such as Graphene, MXene, Black phosphorene (BP), and Blue phosphorene (BlueP) in order to search optimum parameters, and then we implement the best one in each layer of this biosensor design. It is noticed that the SPR heterostructure based on BAK1 prism, plasmonic metal Ag, tungsten disulfide (WS2) TMDC, formamidinium tin iodide (FASnI3) HP and 2D BP exhibits outstanding performance with regard to sensor performance characteristics. The observed FoM and sensitivity are 48.2/RIU and 402°/RIU, respectively. The investigation of the electric field distribution within this biosensor along the normal to the interface is also conducted using the finite difference time domain (FDTD) approach to demonstrate the unique contribution of FASnI3. The findings presented in this study are anticipated to play a key role in the improvement of plasmonic resonance-based biosensing domains like DNA hybridization or formalin detection by employing halide perovskite as an additional layer in SPR biosensors.
{"title":"Numerical investigation into impact of halide perovskite material on the optical performance of prism-loaded hybrid surface plasmon resonance biosensor: A strategy to increase sensitivity","authors":"Sourav Roy , Nibir Mondol , Diponkar Kundu , Anisha Anjum Meem , Md. Rasidul Islam , Md. Amzad Hossain , Md. Biplob Hossain","doi":"10.1016/j.sbsr.2024.100630","DOIUrl":"https://doi.org/10.1016/j.sbsr.2024.100630","url":null,"abstract":"<div><p>The technology of surface plasmon resonance (SPR) is widely recognized and valued for its ability to rapidly and sensitively investigate biomolecular interactivities in real-time. Herein, we numerically investigate the collective influence of metal/ transition metal dichalcogenide (TMDC)/halide perovskite (HP)/2D carbon (C) and phosphorus (P) allotropes on the functionality of an SPR biosensor deploying Kretschmann configuration. The incident light wavelength is held constant at 633 nm, and radiative properties of the hybrid structure are determined using the attenuated total reflection and transfer matrix techniques. Crucial performance metrics such as quality factor (QF), figure of merit (FoM), sensitivity, and detection accuracy are calculated. The comparison is conducted and evaluated against the current literature using performance outcomes in terms of several prisms such as BK7, BAK1, BAF10, SF5, SF10, SF11, 2S2G, CaF<sub>2</sub>, and CsF, several TMDCs such as WS<sub>2</sub>, MoS<sub>2</sub>, WSe<sub>2</sub>, MoSe<sub>2</sub>, and PtSe<sub>2</sub>, several HPs such as CsPbI<sub>3</sub>, KSnI<sub>3</sub>, CsSnI<sub>3</sub>, and FASnI<sub>3</sub>, and 2D C/P allotropes such as Graphene, MXene, Black phosphorene (BP), and Blue phosphorene (BlueP) in order to search optimum parameters, and then we implement the best one in each layer of this biosensor design. It is noticed that the SPR heterostructure based on BAK1 prism, plasmonic metal Ag, tungsten disulfide (WS<sub>2</sub>) TMDC, formamidinium tin iodide (FASnI<sub>3</sub>) HP and 2D BP exhibits outstanding performance with regard to sensor performance characteristics. The observed FoM and sensitivity are 48.2/RIU and 402°/RIU, respectively. The investigation of the electric field distribution within this biosensor along the normal to the interface is also conducted using the finite difference time domain (FDTD) approach to demonstrate the unique contribution of FASnI<sub>3</sub>. The findings presented in this study are anticipated to play a key role in the improvement of plasmonic resonance-based biosensing domains like DNA hybridization or formalin detection by employing halide perovskite as an additional layer in SPR biosensors.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000126/pdfft?md5=6507c07644f71f6f9457c13e30b5d0be&pid=1-s2.0-S2214180424000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.sbsr.2024.100636
Jan Dominiczak , Jakub Krzemiński , Justyna Wojcieszek , Dominik Baraniecki , Filip Budny , Izabela Wojciechowska , Piotr Walter , Andrzej Pepłowski , Łukasz Górski , Małgorzata Jakubowska
Manufacturing technology of ion-selective electrodes (ISEs) for pH measurements is presented. Plasticized polyurethane membranes with tridodecylamine as a pH-selective ionophore were used as receptor layer, whereas electrodes printed with graphene nanoplatelets paste served as transducers. For preliminary experiments, sensors with screen-printed transducers and pH-selective membranes deposited manually or by direct-ink writing, were employed. However, the use of aerosol-jet printing (AJP) technique for the production of transducer as well as deposition of pH-selective polymeric membrane allowed substantial miniaturization of the sensors, leading to low-cost, automated fabrication of millimeter-scale ISEs. The pH sensors were printed on thermoplastic polyurethane (TPU) or polyethylene terephthalate (PET) substrate, the issues of compatibility of membrane and substrate materials were addressed. The average membrane thickness for the ISEs was 225.2 ± 8.0 μm with an additional 20 μm average thickness of other underlying printed layers. The planar dimensions of ISEs were 300 μm (width) by 2 mm, presenting an opportunity for even further miniaturization. Sensors fully printed with the AJP technique yielded a potentiometric response of −53.48 ± 4.26 mV/pH (N = 69) for PET substrate and − 46.71 ± 10.23 mV/pH (N = 66) for TPU substrate. Presented results are important for developing a fully operational electronic tattoo suitable for large-scale manufacturing.
{"title":"Aerosol-jet-printed potentiometric pH sensor for sweat measurements in smart patches","authors":"Jan Dominiczak , Jakub Krzemiński , Justyna Wojcieszek , Dominik Baraniecki , Filip Budny , Izabela Wojciechowska , Piotr Walter , Andrzej Pepłowski , Łukasz Górski , Małgorzata Jakubowska","doi":"10.1016/j.sbsr.2024.100636","DOIUrl":"10.1016/j.sbsr.2024.100636","url":null,"abstract":"<div><p>Manufacturing technology of ion-selective electrodes (ISEs) for pH measurements is presented. Plasticized polyurethane membranes with tridodecylamine as a pH-selective ionophore were used as receptor layer, whereas electrodes printed with graphene nanoplatelets paste served as transducers. For preliminary experiments, sensors with screen-printed transducers and pH-selective membranes deposited manually or by direct-ink writing, were employed. However, the use of aerosol-jet printing (AJP) technique for the production of transducer as well as deposition of pH-selective polymeric membrane allowed substantial miniaturization of the sensors, leading to low-cost, automated fabrication of millimeter-scale ISEs. The pH sensors were printed on thermoplastic polyurethane (TPU) or polyethylene terephthalate (PET) substrate, the issues of compatibility of membrane and substrate materials were addressed. The average membrane thickness for the ISEs was 225.2 ± 8.0 μm with an additional 20 μm average thickness of other underlying printed layers. The planar dimensions of ISEs were 300 μm (width) by 2 mm, presenting an opportunity for even further miniaturization. Sensors fully printed with the AJP technique yielded a potentiometric response of −53.48 ± 4.26 mV/pH (<em>N</em> = 69) for PET substrate and − 46.71 ± 10.23 mV/pH (<em>N</em> = 66) for TPU substrate. Presented results are important for developing a fully operational electronic tattoo suitable for large-scale manufacturing.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000187/pdfft?md5=bed6e922c30218d8d430821ef1090a45&pid=1-s2.0-S2214180424000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140019617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study reports the determination of Tinidazole (TDL) using a modified glassy carbon electrode, poly(bis(2,2′-bipyridine)diresorcinateruthenium(III) chloride) (poly(BBPDRRuC)/GCE) by a newly synthesized mixed ligand complex, bis-(2,2′-bipyridine)diresorcinateruthenium(III) chloride(BBPDRRuC). Electrochemical impedance spectroscopy (EIS) and cyclic voltamettry (CV) results demonstrated modification of the surface of the electrode by a conductive, and electroactive polymer film leading to an enhanced effective electrode surface area and their electrocatalytic role. Appearance of an irreversible reductive peak at much reduced potential with four folds current enhancement at poly(BBPDRRuC)/GCE showed the catalytic effect of the modifier by reduction of TDL. Square wave voltammetry current response of poly(BBPDRRuC)/GCE showed linear dependence on concentration of TDL in the range 10−8˗ 3.0 × 10−4 M with LoD and LoQ of 2.5 nM, and 8.2 nM, respectively. The TDL level in the studied tablet brands were in the range 96.6–101.1% of their labeled values. Spike recovery results in tablet, and human blood serum samples were in the range 98.3˗100.4%, and 98.85 ˗ 99.89%, respectively, and interference recovery results with <4.5% error. The developed method required a simple electrode modification step, a relatively chip, an easily available and non-toxic modifier, provides the least LoD, and reasonably wider linear dynamic range, and had excellent performance for the determination of TDL in tablet formulation and serum samples as compared with recently reported voltammetric methods.
{"title":"Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode","authors":"Getasil Chanie , Adane Kassa , Getinet Tamiru Tigineh , Atakilt Abebe","doi":"10.1016/j.sbsr.2023.100607","DOIUrl":"10.1016/j.sbsr.2023.100607","url":null,"abstract":"<div><p>This study reports the determination of Tinidazole (TDL) using a modified glassy carbon electrode, poly(bis(2,2′-bipyridine)diresorcinateruthenium(III) chloride) (poly(BBPDRRuC)/GCE) by a newly synthesized mixed ligand complex, bis-(2,2′-bipyridine)diresorcinateruthenium(III) chloride(BBPDRRuC). Electrochemical impedance spectroscopy (EIS) and cyclic voltamettry (CV) results demonstrated modification of the surface of the electrode by a conductive, and electroactive polymer film leading to an enhanced effective electrode surface area and their electrocatalytic role. Appearance of an irreversible reductive peak at much reduced potential with four folds current enhancement at poly(BBPDRRuC)/GCE showed the catalytic effect of the modifier by reduction of TDL. Square wave voltammetry current response of poly(BBPDRRuC)/GCE showed linear dependence on concentration of TDL in the range 10<sup>−8</sup>˗ 3.0 × 10<sup>−4</sup> M with LoD and LoQ of 2.5 nM, and 8.2 nM, respectively. The TDL level in the studied tablet brands were in the range 96.6–101.1% of their labeled values. Spike recovery results in tablet, and human blood serum samples were in the range 98.3˗100.4%, and 98.85 ˗ 99.89%, respectively, and interference recovery results with <4.5% error. The developed method required a simple electrode modification step, a relatively chip, an easily available and non-toxic modifier, provides the least LoD, and reasonably wider linear dynamic range, and had excellent performance for the determination of TDL in tablet formulation and serum samples as compared with recently reported voltammetric methods.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180423000594/pdfft?md5=916d0ba85a73cb3211d418624fa64ac4&pid=1-s2.0-S2214180423000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138743514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}