Sensing and Bio-Sensing Research最新文献

英文中文

Development of an electrochemiluminescence immunosensor for diagnosis of cystic echinococcosis using a BSA-AuNCs-chitosan-AgNPs-luminol nanocomposite 利用bsa - auncs -壳聚糖- agnps -鲁米诺纳米复合材料研制诊断囊性包虫病的电化学发光免疫传感器

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-05 DOI: 10.1016/j.sbsr.2025.100939

Hassan Nasrollahpour , Sepideh Shafaei , Mohamadreza Rashidi , Ehsan Ahmadpour , Balal Khalilzadeh

Cystic echinococcosis (CE) is a serious zoonotic disease that affects humans and animals worldwide and is caused by the parasite Echinococcus granulosus, which lives in dogs as its final host. Detecting the disease early is vital to prevent serious health problems. However, in the early stages of infection, the body produces only very low levels of antibodies against the parasite. Because of this, routine laboratory tests often struggle to identify the infection at this stage. In this study, we designed a highly sensitive electrochemiluminescence (ECL) immunosensor to detect CE. To amplify the detection signal, we used chitosan–gold nanoclusters decorated with silver nanoparticles (CS-AuNCs-AgNPs), together with a luminol/H₂O₂ ECL system. These nanomaterials were rapidly and uniformly deposited on the electrode surface using chronoamperometry technique, creating a stable nanofilm in just 2 min. We then immobilized antigen B on the electrode as a biological recognition layer to capture CE-specific antibodies. When serum from an experimentally infected mouse was applied, binding of the antibodies to antigen B reduced the ECL signal due to steric hindrance serving as our detection indicator. The successful assembly of nanomaterials on the electrode surface was confirmed using SEM, EDX, and dot-plot analyses. Overall, this work presents a sensitive, rapid, and reproducible platform that holds strong potential for early clinical detection of cystic echinococcosis.

囊性棘球蚴病（CE）是一种严重的人畜共患疾病，在世界范围内影响人类和动物，由颗粒棘球绦虫引起，作为其最终宿主生活在狗身上。及早发现这种疾病对于预防严重的健康问题至关重要。然而，在感染的早期阶段，身体只产生非常低水平的针对寄生虫的抗体。因此，在这一阶段，常规实验室检查往往难以识别感染。在这项研究中，我们设计了一种高灵敏度的电化学发光（ECL）免疫传感器来检测CE。为了放大检测信号，我们使用了壳聚糖-金纳米团簇修饰银纳米粒子（CS-AuNCs-AgNPs），以及鲁米诺/H2O2 ECL系统。这些纳米材料使用计时电流测定技术快速均匀地沉积在电极表面，仅在2分钟内形成稳定的纳米膜。然后我们将抗原B固定在电极上作为生物识别层来捕获ce特异性抗体。当应用实验感染小鼠的血清时，抗体与抗原B的结合由于空间位阻而降低了ECL信号，这是我们的检测指标。通过SEM、EDX和点阵分析证实了纳米材料在电极表面的成功组装。总的来说，这项工作提出了一个敏感、快速、可重复的平台，为囊性包虫病的早期临床检测提供了强大的潜力。

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引用次数: 0

SPR biosensors based on low-dimensional carbon materials for trace urine glucose 基于低维碳材料的微量尿糖SPR生物传感器

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-04 DOI: 10.1016/j.sbsr.2025.100935

Talia Tene , Jessica Alexandra Marcatoma Tixi , Ximena Alexandra Quintana López , Lala Gahramanli , Rana Khankishiyeva , Cristian Vacacela Gomez

Surface plasmon resonance (SPR) biosensors are attractive for non-invasive screening of urine glucose, but their performance depends sensitively on the choice of low-dimensional carbon overlayer and metal stack. Here we numerically compare graphene, semiconducting single-walled carbon nanotubes SWCNT (s-SWCNT), graphene oxide (GO), or reduced graphene oxide (rGO) integrated in a standardized CaF₂/Cu/Si₃N₄/(low-D)/urine stack. Using a transfer-matrix model at 633 nm, with a realistic analyte refractive index change (Δn ≈ 4.6 × 10⁻⁴ RIU) corresponding to 0.015–0.225 g dL⁻¹ urine glucose, we extract angular sensitivity, linewidth, quality factor, figure of merit, a combined sensitivity factor and theoretical limits of detection. Within an effective-medium description of the carbon films, rGO delivers the highest sensitivity and lowest detection limits but broader resonance dips; GO yields the narrowest dips and the highest precision; graphene and s-SWCNTs offer intermediate responses with stable linewidths and minimal angle drift. We also identify practical thickness windows for each overlayer on Cu that balance sensitivity against spectral sharpness. Compared with prior SPR studies that focus on a single carbon coating or Au-based stacks, this work provides a unified framework and quantitative design rules to select Cu-based low-dimensional overlayers for resolving small, bulk urine-glucose-induced refractive-index changes above the clinical baseline and to guide subsequent experimental implementations.

表面等离子体共振（SPR）生物传感器在无创筛选尿糖方面具有吸引力，但其性能敏感地取决于低维碳层和金属堆的选择。在这里，我们在数值上比较了石墨烯、半导体单壁碳纳米管SWCNT （s-SWCNT）、氧化石墨烯（GO）或还原氧化石墨烯（rGO）集成在标准化的CaF₂/Cu/Si₃N₄/（低d）/尿液堆中。在633 nm处使用传递矩阵模型，实际分析物折射率变化（Δn≈4.6 × 10−4 RIU）对应0.015-0.225 g dL−1尿糖，我们提取了角灵敏度、线宽、质量因子、优值、组合灵敏度因子和理论检出限。在碳膜的有效介质描述中，还原氧化石墨烯提供了最高的灵敏度和最低的检测限，但更宽的共振倾角；氧化石墨烯产生最小的倾角和最高的精度；石墨烯和s-SWCNTs提供了稳定的线宽和最小角度漂移的中间响应。我们还确定了Cu上每个覆盖层的实际厚度窗口，以平衡灵敏度与光谱清晰度。与以往的SPR研究相比，这项工作提供了一个统一的框架和定量设计规则，以选择基于cu的低维覆盖层来解决超过临床基线的小批量尿葡萄糖诱导的折射率变化，并指导后续的实验实施。

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引用次数: 0

Magnetic particle imaging using a multi-axis optically pumped magnetometer and multiple flux transformers 利用多轴光泵磁强计和多个磁通变压器进行磁粒子成像

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-04 DOI: 10.1016/j.sbsr.2025.100936

Teruyoshi Sasayama , Shuji Taue , Takashi Yoshida

Biofunctionalized magnetic nanoparticles (MNPs) have been widely studied for biomedical applications, including magnetic particle imaging (MPI), which is a promising diagnostic technique for cancer imaging. Because MNPs generate weak magnetic fields, highly sensitive magnetic sensors, such as optically pumped magnetometers (OPMs), are required. In our previous study, we developed an MPI scanner using an OPM and a flux transformer consisting of input and pickup coils. For rapid and accurate MNP position estimation, it is desirable to measure the magnetic field using an OPM array. OPMs that measure magnetic fields along more than two axes are commercially available. However, OPMs are expensive and difficult to array. Therefore, we propose a method for multipoint measurements using a single OPM and multiple flux transformers. In an experiment, the MNPs were magnetized using an AC magnetic field, and the resulting magnetic signals were detected using two parallel differential-type pickup coils. The detected signals were converted into magnetic fields using orthogonal input coils and measured using a dual-axis OPM. Magnetic images were obtained by scanning a diluted Resovist MNP sample with a motorized stage. The signals from each pickup coil were measured independently and simultaneously, confirming the feasibility of multipoint measurements using a single multi-axis OPM.

生物功能化磁性纳米颗粒（MNPs）在生物医学领域的应用得到了广泛的研究，包括磁颗粒成像（MPI），这是一种很有前途的癌症成像诊断技术。由于MNPs产生弱磁场，因此需要高灵敏度的磁传感器，如光泵浦磁强计（opm）。在我们之前的研究中，我们使用OPM和由输入线圈和拾取线圈组成的磁通变压器开发了MPI扫描仪。为了快速准确地估计MNP位置，需要使用OPM阵列测量磁场。沿着两个以上的轴测量磁场的opm在商业上是可用的。然而，opm既昂贵又难以排列。因此，我们提出了一种使用单个OPM和多个磁通变压器进行多点测量的方法。实验中，用交流磁场对MNPs进行磁化，并使用两个并联差分型拾取线圈检测产生的磁信号。通过正交输入线圈将检测到的信号转换成磁场，并使用双轴OPM进行测量。磁图像是通过扫描稀释的Resovist MNP样品与电动平台。来自每个拾取线圈的信号被独立地同时测量，证实了使用单个多轴OPM进行多点测量的可行性。

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引用次数: 0

Corrigendum to “Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges” <[Sensing and Bio-Sensing Research Volume 48, June 2025, 100783]> “纳米增强生物传感器的最新进展：设计创新、在医疗保健、环境监测和食品安全中的应用以及新出现的研究挑战”的勘误表

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-01 DOI: 10.1016/j.sbsr.2025.100903

Mohamed Hemdan , Khaled Abuelhaded , Abanoub A.S. Shaker , Mohamed M. Ashour , Moustafa M. Abdelaziz , Mohammed I. Dahab , Yara A. Nassar , Amir M.M. Sarguos , Pola S. Zakaria , Haidy A. Fahmy , Sherif S. Abdel Mageed , Mariam O.A. Hamed , Mahmoud F. Mubarak , Mostafa A. Taher , Najla F. Gumaah , Ahmed H. Ragab

引用次数: 0

Corrigendum to “Wavefront-modulated Fabry–Perot fiber biosensor for label-free Lysozyme detection via coupling efficiency analysis” [Sensing and Bio-Sensing Research Volume 50 (December 2025) Article 100901] “通过耦合效率分析用于无标签溶菌酶检测的波前调制法布里-珀罗纤维生物传感器”的勘误表[传感和生物传感研究卷50（2025年12月）第100901条]

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-01 DOI: 10.1016/j.sbsr.2025.100911

Alain Castaño Andres , Javier Barroso , Joseba Zubia , Oskar Arrizabalaga

引用次数: 0

Identification of Acinetobacter baumannii based on plasmonic patterns of silver nanoprism reinforced with 3,3′,5,5′-tetramethylbenzidine and hydrogen peroxide: An innovative DNA-based optical biosensor 基于3,3 ',5,5 ' -四甲基联苯胺和过氧化氢增强银纳米片等离子体模式的鲍曼不动杆菌鉴定：一种创新的dna光学生物传感器

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-01 DOI: 10.1016/j.sbsr.2025.100923

Mahdieh Azimi , Farnaz Bahavarnia , Mohammad Hasanzadeh , Nasrin Shadjou

In this study, silver nanoprisms (AgNPrs) was utilized as optical probe to create advanced DNA-based biosensor (genosensor) for detecting target sequences (cDNA) of A. baumannii using oligonucleotides hybridization strategy. The engineered genosensor demonstrated exceptional sensitivity in the dynamic range from 10⁻¹⁸ to 10⁻⁶ M. The genosensor achieved a low limit of quantification of 10⁻¹⁸ M, making it a highly effective alternative to traditional detection methods. Additionally, specify of the biosensor's was assessed, particularly regarding two mismatch sequences, allowing precise measurement of A. baumannii without extensive preparation steps. Therefore, an efficient biosensor was developed for real-time monitoring and tracking in pathogen detection and introduced DNA-based biosensors as a powerful and next generation diagnostic approach of bacterial infections.

本研究以银纳米片（AgNPrs）为光学探针，利用寡核苷酸杂交策略，建立了先进的基于dna的生物传感器（基因传感器），用于检测鲍曼不动杆菌的靶序列（cDNA）。该基因传感器在10 - 18至10 - 6 M的动态范围内表现出卓越的灵敏度。该基因传感器的定量下限为10 - 18 M，使其成为传统检测方法的高效替代品。此外，对生物传感器的特性进行了评估，特别是关于两个不匹配序列，允许精确测量鲍曼不动杆菌，而无需大量的准备步骤。因此，我们开发了一种高效的生物传感器，用于实时监测和跟踪病原体检测，并将基于dna的生物传感器作为下一代细菌感染的强大诊断方法。

引用次数: 0

Machine learning-driven terahertz graphene-MXene-gold metasurface biosensor for dual COVID-19 and cervical cancer biomarker detection 机器学习驱动的太赫兹石墨烯- mxene -金超表面生物传感器，用于双重COVID-19和宫颈癌生物标志物检测

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-01 DOI: 10.1016/j.sbsr.2025.100920

Jacob Wekalao , Hussein A. Elsayed , Haifa A. Alqhtani , Mostafa R. Abukhadra , Ahmed Mehaney , Amuthakkannan Rajakannu

This study introduces a terahertz (THz) biosensor designed for rapid and precise detection of COVID-19 viral proteins and cervical cancer biomarkers. The device uses a metasurface structure composed of U-shaped MXene-coated resonators and L-shaped gold-coated elements on a graphene-functionalized circular platform built on a silicon dioxide substrate. It operates across 0.308–0.312 THz for COVID-19 detection and 0.799–0.809 THz for cervical cancer screening, achieving sensitivities of 200 GHz/RIU and 300 GHz/RIU. The corresponding figures of merit range from 2.222 to 2.667 RIU⁻¹ for COVID-19 and 4.848–5.455 RIU⁻¹ for cervical cancer, with quality factors above 14 for the latter. A one-dimensional convolutional neural network model optimized the sensor's response, reaching up to 95 % prediction accuracy and showing a strong linear correlation between resonance frequency and refractive index (R² > 0.99). The architecture can be produced using standard lithography and thin-film deposition methods compatible with existing microelectronic processes. The design allows biofunctionalization with target proteins such as SARS-CoV-2 spike antigens and HPV-related biomarkers. Simulation results align with recent experimental findings in THz biosensing, supporting the feasibility of laboratory testing and clinical application.

本研究介绍了一种用于快速精确检测COVID-19病毒蛋白和宫颈癌生物标志物的太赫兹（THz）生物传感器。该装置采用了一种超表面结构，由u形mxene涂层谐振器和l形金涂层元件组成，该结构位于二氧化硅衬底上的石墨烯功能化圆形平台上。其检测范围为0.308-0.312太赫兹，宫颈癌筛查范围为0.799-0.809太赫兹，灵敏度分别为200 GHz/RIU和300 GHz/RIU。相应的优值在COVID-19的2.222 ~ 2.667 RIU−1和宫颈癌的4.848 ~ 5.455 RIU−1之间，后者的质量因子在14以上。一维卷积神经网络模型优化了传感器的响应，预测精度高达95%，共振频率与折射率之间存在很强的线性相关性（R2 > 0.99）。该结构可以使用与现有微电子工艺兼容的标准光刻和薄膜沉积方法来生产。该设计允许与靶蛋白（如SARS-CoV-2刺突抗原和hpv相关生物标志物）进行生物功能化。仿真结果与太赫兹生物传感的最新实验结果一致，支持实验室测试和临床应用的可行性。

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引用次数: 0

Corrigendum to “A robust and highly sensitive electrochemical probe for detection of trace levels of NH3/NH4+ in water based on Berthelot's reaction” [Sensing and Bio-Sensing Research 47 (2025) 100760]. “基于Berthelot反应的用于检测水中痕量NH3/NH4+的坚固和高灵敏度电化学探针”[传感和生物传感研究47(2025)100760]的勘误表。

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-01 DOI: 10.1016/j.sbsr.2025.100905

H. Alwael , A.S. Alharthi , A. Alsolami , M. Oubaha , B. Duffy , R.M. Elshafey , M.S. El-Shahawi

引用次数: 0

Dual emissive carbon dots as Ratiometric fluorescence sensors: A comprehensive review 作为比例荧光传感器的双发射碳点：综述

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-01 DOI: 10.1016/j.sbsr.2025.100930

Samar H. Elagamy , Reem Hasan Obaydo , Aya Barseem , Hayam Lotfy

Ratiometric fluorescence sensing offers significant advantages over traditional fluorescence techniques due to its inherent self-referencing nature, enabling robust and accurate measurements. This review focuses on the utilization of Carbon Dots (CDs) as promising platforms for developing ratiometric fluorescence sensors RFS. It outlines the fundamental principles of ratiometric sensing, highlighting its advantages over traditional fluorescence methods. The sensing mechanisms employed in ratiometric sensors are discussed, including intramolecular charge transfer (ICT), fluorescence resonance energy transfer (FRET), chelation-enhanced fluorescence (CHEF), photoinduced electron transfer (PET), excited-state intramolecular proton transfer (ESIPT), aggregation-induced emission (AIE), static quenching effect (SQE), dynamic quenching (DQE) and internal filtration effect (IFE). Furthermore, various methods for constructing CD-based RFS are investigated in this review, including surface functionalization, doping, mixing strategy, hybridization/compositing, and synthesis of intrinsic dual-emissive CDs. In addition, the diverse applications of CD-based RFS in key areas are discussed, such as environmental monitoring, food safety analysis, pharmaceutical analysis, bioanalysis, and bioimaging. Finally, this review highlights the challenges associated with CD-based RFS and outlines potential directions for future research.

比率荧光传感由于其固有的自参考特性，比传统的荧光技术具有显著的优势，能够实现鲁棒和准确的测量。本文综述了利用碳点（cd）作为有前途的平台来开发比率荧光传感器。它概述了比率传感的基本原理，突出了其优于传统荧光方法的优点。讨论了用于比例传感器的传感机制，包括分子内电荷转移（ICT）、荧光共振能量转移（FRET）、螯合增强荧光（CHEF）、光诱导电子转移（PET）、激化态分子内质子转移（ESIPT）、聚集诱导发射（AIE）、静态猝灭效应（SQE）、动态猝灭效应（DQE）和内部过滤效应（IFE）。此外，本文还研究了构建基于cd的RFS的各种方法，包括表面功能化、掺杂、混合策略、杂化/复合以及合成本征双发射cd。此外，还讨论了基于cd的RFS在环境监测、食品安全分析、药物分析、生物分析和生物成像等关键领域的应用。最后，本综述强调了基于cd的RFS所面临的挑战，并概述了未来研究的潜在方向。

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引用次数: 0

Design of La@ZnO/AuNPs/GO nanocomposites as an electrochemical sensor for acetaminophen detection La@ZnO/AuNPs/GO纳米复合材料检测对乙酰氨基酚的电化学传感器设计

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research

Pub Date : 2025-12-01 DOI: 10.1016/j.sbsr.2025.100929

Hamna Shafaq , Saima Anjum , Sidra Tul Muntaha , Nawal Qureshi , Muhammad Imran Khan , Abdallah Shanableh , Sameh M. Osman , Rafael Luque

This study was aimed to design an innovative and highly sensitive electrochemical sensor for Acetaminophen analysis. La@ZnO/AuNPs/GO nanocomposite was synthesized via hydrothermal approach for the detection of acetaminophen in pharmaceutical products and biological samples. Characterization of La@ZnO/AuNPs/GO was conducted using UV–visible spectroscopy, Fourier transform infrared, X-ray powder diffraction, EIS and electrochemical determination was carried out by DPV and CV. Voltammetric results showed an increased oxidation peak current due to fast electron transfer, which confirmed the oxidation of acetaminophen. DPV was performed for different concentrations of acetaminophen in the range of 0.5–1750 μM. LOD and LOQ for La@ZnO/AuNPs/GO were 0.45 μM and 1.50 μM respectively, for AP detection. The sensor demonstrated a remarkably wide linear detection range, a low detection limit, sustained stability over 25 days, minimal interference, rapid determination capabilities, excellent reproducibility, and consistent repeatability for precise Acetaminophen quantification. These findings indicate that La@ZnO/AuNPs/GO is an exceptional electrode material for identifying the electrocatalytic activity of low-level Acetaminophen.

本研究旨在设计一种创新的、高灵敏度的电化学传感器用于对乙酰氨基酚的分析。通过水热法合成了La@ZnO/AuNPs/氧化石墨烯纳米复合材料，用于药品和生物样品中对乙酰氨基酚的检测。利用紫外可见光谱、傅里叶变换红外光谱、x射线粉末衍射、EIS对La@ZnO/AuNPs/GO进行表征，并通过DPV和CV进行电化学测定。伏安结果表明，由于快速的电子转移，氧化峰电流增加，证实了对乙酰氨基酚的氧化作用。对乙酰氨基酚在0.5 ~ 1750 μM范围内进行DPV。La@ZnO/AuNPs/GO的AP检测LOD和LOQ分别为0.45 μM和1.50 μM。该传感器具有非常宽的线性检测范围、低检出限、25天以上的持续稳定性、最小的干扰、快速的测定能力、出色的重现性和精确的对乙酰氨基酚定量的一致性。这些发现表明La@ZnO/AuNPs/GO是一种特殊的电极材料，用于鉴定低水平对乙酰氨基酚的电催化活性。

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