Sensors and Actuators B: Chemical最新文献

英文中文

A fluorescent optical fiber sensor for real-time, portable detection of alkaline phosphatase activity

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137568

Dan Li , Yutao Shen , Na Li , Xiaolong Li , Mao Li , Zijia Huang , Yong Zhao

Alkaline phosphatase (ALP) is ubiquitous in mammalian tissues, facilitating the dephosphorylation of diverse biomolecules. As a key biomarker, ALP activity monitoring is of great significance for clinical research and disease diagnosis. Here, a sensitive and portable fluorescent fiber optic sensor based on silicon quantum dots (SiQDs) was developed for detecting ALP activity. Green-fluorescent SiQDs were synthesized using a one-pot hydrothermal method. A tapered optical fiber was facilely modified with SiQDs through in situ hydrogel polymerization reaction. The hydrogel-based optical fiber ALP sensor was meticulously designed by incorporating ALP-triggered cascade reaction. ALP catalyzes the substrate hydrolysis to produce ascorbic acid (AA), which then triggers a chromogenic redox reaction between AA and Cu(II)-neocuproine chelate to form highly colored Cu(I)-chelate, effectively quenching the fluorescence of the SiQDs due to inner filter effect. This method provides a linear detection of ALP activity within the range of 0.02–2.0 U/L. The sensor was applied to ALP activity detection in real serum samples, demonstrating its practicability and reliability. This sensor offers the advantages of high sensitivity (a detection limit of 0.015 U/L), exceptional selectivity, good practicability and simplified fabrication, presenting a portable and efficient technique for on-line ultrasensitive detection of ALP activity in biological samples. It provides a new perspective for developing high-performance optical fiber sensors, with significant practical value for applications in health monitoring, clinical diagnostics, and emergency analysis.

{"title":"A fluorescent optical fiber sensor for real-time, portable detection of alkaline phosphatase activity","authors":"Dan Li , Yutao Shen , Na Li , Xiaolong Li , Mao Li , Zijia Huang , Yong Zhao","doi":"10.1016/j.snb.2025.137568","DOIUrl":"10.1016/j.snb.2025.137568","url":null,"abstract":"<div><div>Alkaline phosphatase (ALP) is ubiquitous in mammalian tissues, facilitating the dephosphorylation of diverse biomolecules. As a key biomarker, ALP activity monitoring is of great significance for clinical research and disease diagnosis. Here, a sensitive and portable fluorescent fiber optic sensor based on silicon quantum dots (SiQDs) was developed for detecting ALP activity. Green-fluorescent SiQDs were synthesized using a one-pot hydrothermal method. A tapered optical fiber was facilely modified with SiQDs through in situ hydrogel polymerization reaction. The hydrogel-based optical fiber ALP sensor was meticulously designed by incorporating ALP-triggered cascade reaction. ALP catalyzes the substrate hydrolysis to produce ascorbic acid (AA), which then triggers a chromogenic redox reaction between AA and Cu(II)-neocuproine chelate to form highly colored Cu(I)-chelate, effectively quenching the fluorescence of the SiQDs due to inner filter effect. This method provides a linear detection of ALP activity within the range of 0.02–2.0 U/L. The sensor was applied to ALP activity detection in real serum samples, demonstrating its practicability and reliability. This sensor offers the advantages of high sensitivity (a detection limit of 0.015 U/L), exceptional selectivity, good practicability and simplified fabrication, presenting a portable and efficient technique for on-line ultrasensitive detection of ALP activity in biological samples. It provides a new perspective for developing high-performance optical fiber sensors, with significant practical value for applications in health monitoring, clinical diagnostics, and emergency analysis.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137568"},"PeriodicalIF":8.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of ultrafast-walking stochastic 3D dual-DNA walker nanoprobes for highly sensitive fluorescence detection of extracellular vesicles for cancer diagnosis

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137578

Qingyi Liu , Qiongdan Zhang , Ruiyue Zhang , Zichen Wen , Zhijian Yao , Bin Li , Zheng Yang , Jinhui Hu , Wei Wang , Huizhen Wang , Caiyun Peng

Extracellular vesicles (EVs) serve as a promising biomarker for the early screening and monitoring of cancer through non-invasive testing. However, achieving rapid and sensitive detection of tumor-derived extracellular vesicles (TEVs) remains a significant challenge. In this study, we report an ultrafast-walking stochastic three-dimensional (3D) dual-DNA walker nanoprobes (D-DWN)-based fluorescence biosensor for the detection of EVs. The D-DWN facilitates autonomous movement on AuNP at high speeds, powered by Exo III, which results in the release of fluorophores that act as an analytical signal for the detection of target EVs. Compared to traditional DNA walkers, our proposed D-DWN demonstrates superior reaction kinetics, achieving saturation within 20 min. This advancement enables highly sensitive detection of EVs, with a linear response range from 8 × 10⁵ to 1.28 × 10⁷ particles/μL and a limit of detection of 1.18 particles/μL. Furthermore, clinical samples can be analyzed using the D-DWN to differentiate patients with cancer from healthy individuals. This work is anticipated to provide an effective tool for the accurate detection of EVs, offering potential for early cancer diagnosis and postoperative response prediction.

{"title":"Construction of ultrafast-walking stochastic 3D dual-DNA walker nanoprobes for highly sensitive fluorescence detection of extracellular vesicles for cancer diagnosis","authors":"Qingyi Liu , Qiongdan Zhang , Ruiyue Zhang , Zichen Wen , Zhijian Yao , Bin Li , Zheng Yang , Jinhui Hu , Wei Wang , Huizhen Wang , Caiyun Peng","doi":"10.1016/j.snb.2025.137578","DOIUrl":"10.1016/j.snb.2025.137578","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) serve as a promising biomarker for the early screening and monitoring of cancer through non-invasive testing. However, achieving rapid and sensitive detection of tumor-derived extracellular vesicles (TEVs) remains a significant challenge. In this study, we report an ultrafast-walking stochastic three-dimensional (3D) dual-DNA walker nanoprobes (D-DWN)-based fluorescence biosensor for the detection of EVs. The D-DWN facilitates autonomous movement on AuNP at high speeds, powered by Exo III, which results in the release of fluorophores that act as an analytical signal for the detection of target EVs. Compared to traditional DNA walkers, our proposed D-DWN demonstrates superior reaction kinetics, achieving saturation within 20 min. This advancement enables highly sensitive detection of EVs, with a linear response range from 8 × 10<sup>5</sup> to 1.28 × 10<sup>7</sup> particles/μL and a limit of detection of 1.18 particles/μL. Furthermore, clinical samples can be analyzed using the D-DWN to differentiate patients with cancer from healthy individuals. This work is anticipated to provide an effective tool for the accurate detection of EVs, offering potential for early cancer diagnosis and postoperative response prediction.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137578"},"PeriodicalIF":8.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A β-keto-enamine covalent organic framework fluorescent switch for selective and sensitive UO22 + detection

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137564

Yu Liu , Chunlin Liu , Qiuhui Deng , Yao Yu , Xian Tang , Le Li , Craig A. Grimes , Shengyuan Yang , Qingyun Cai , Deshuai Zhen

Nuclear accidents, uranium mining, and nuclear weapons production pose significant health and environmental concerns, and as a consequence there is ongoing interest in techniques for rapid and selective detection of the uranyl ion (UO₂²⁺). In this study, a β-keto-enamine-linked covalent organic framework (COF) fluorescent probe was synthesized by a simple one-step condensation reaction using 1,3,5-triformylphoroglucinol (Tp) and 3,3′-dihydroxybenzidine (Db). Tp-Db exhibited a UO₂²⁺ detection limit of 99.34 nM and a 10 s reaction time, making it suitable for rapid detection in diverse environmental samples including river water, nuclear wastewater, food, and urine. Experimental analyses and density-functional theory (DFT) calculations reveal that UO₂²⁺ preferentially coordinates with the carbonyl group in Tp-Db through intramolecular charge transfer and electrostatic interactions, and the presence of the hydroxyl assistant group further improves the binding affinity. This study elucidates the interaction mechanism of different functional groups (carbonyl, hydroxyl, and imine) with UO₂²⁺ within the channels of the keto-enamine-linked COF, providing a promising rational basis for the development of an advanced UO₂²⁺ sensing platform.

{"title":"A β-keto-enamine covalent organic framework fluorescent switch for selective and sensitive UO22 + detection","authors":"Yu Liu , Chunlin Liu , Qiuhui Deng , Yao Yu , Xian Tang , Le Li , Craig A. Grimes , Shengyuan Yang , Qingyun Cai , Deshuai Zhen","doi":"10.1016/j.snb.2025.137564","DOIUrl":"10.1016/j.snb.2025.137564","url":null,"abstract":"<div><div>Nuclear accidents, uranium mining, and nuclear weapons production pose significant health and environmental concerns, and as a consequence there is ongoing interest in techniques for rapid and selective detection of the uranyl ion (UO<sub>2</sub><sup>2+</sup>). In this study, a β-keto-enamine-linked covalent organic framework (COF) fluorescent probe was synthesized by a simple one-step condensation reaction using 1,3,5-triformylphoroglucinol (Tp) and 3,3′-dihydroxybenzidine (Db). Tp-Db exhibited a UO<sub>2</sub><sup>2+</sup> detection limit of 99.34 nM and a 10 s reaction time, making it suitable for rapid detection in diverse environmental samples including river water, nuclear wastewater, food, and urine. Experimental analyses and density-functional theory (DFT) calculations reveal that UO<sub>2</sub><sup>2+</sup> preferentially coordinates with the carbonyl group in Tp-Db through intramolecular charge transfer and electrostatic interactions, and the presence of the hydroxyl assistant group further improves the binding affinity. This study elucidates the interaction mechanism of different functional groups (carbonyl, hydroxyl, and imine) with UO<sub>2</sub><sup>2+</sup> within the channels of the keto-enamine-linked COF, providing a promising rational basis for the development of an advanced UO<sub>2</sub><sup>2+</sup> sensing platform.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137564"},"PeriodicalIF":8.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ crystal plane derivation engineering of MOF/MXene inducing electron backflow effect for enhanced triethylamine sensing

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137577

Weining Liu , Xiaoyang Liu , Xi Tan , Mingyang Zhao , Zhao Liu , Ming Yi , Qi Ding , Yaqian Ren , Hairong Li

Triethylamine (TEA) presents considerable threats to public health and production safety because of its toxic and explosive nature, highlighting the urgent need to develop high-performance sensing materials. Traditionally, gas-sensing elements based on p-type metal oxide semiconductor (MOS) have been hindered by their intrinsically low carrier mobility, resulting in performance inferior to n-type MOS. Herein, we successfully constructed Cr₂O₃/TiO₂-X (MCT-X) heterostructures through a in-situ MOF/MXene-derived strategy. The abundant porous nature, along with its increased specific surface area and numerous surface defects, facilitated the interaction between TEA and active centers. Meanwhile, the tightly coupled p-n heterostructures not only enabled rapid carrier migration but also exhibited a rare electron backflow effect. The multidimensional synergistic effects conferred upon MCT-X with excellent sensing properties. The optimal MCT-2 exhibited an outstanding response of 450.01 for TEA (100 ppm, 134 °C), along with superior selectivity, linearity, and stability. Density Functional Theory (DFT) calculations reveal in-depth explanation of the anisotropic charge transport mechanism induced by differences in crystal planes contacts and the sensitization mechanism of the heterostructure. This distinctive synthesis approach, combined with comprehensive mechanistic analysis, offers a strategy for the design of advanced TEA sensing materials.

{"title":"In situ crystal plane derivation engineering of MOF/MXene inducing electron backflow effect for enhanced triethylamine sensing","authors":"Weining Liu , Xiaoyang Liu , Xi Tan , Mingyang Zhao , Zhao Liu , Ming Yi , Qi Ding , Yaqian Ren , Hairong Li","doi":"10.1016/j.snb.2025.137577","DOIUrl":"10.1016/j.snb.2025.137577","url":null,"abstract":"<div><div>Triethylamine (TEA) presents considerable threats to public health and production safety because of its toxic and explosive nature, highlighting the urgent need to develop high-performance sensing materials. Traditionally, gas-sensing elements based on p-type metal oxide semiconductor (MOS) have been hindered by their intrinsically low carrier mobility, resulting in performance inferior to n-type MOS. Herein, we successfully constructed Cr<sub>2</sub>O<sub>3</sub>/TiO<sub>2</sub>-X (MCT-X) heterostructures through a in-situ MOF/MXene-derived strategy. The abundant porous nature, along with its increased specific surface area and numerous surface defects, facilitated the interaction between TEA and active centers. Meanwhile, the tightly coupled p-n heterostructures not only enabled rapid carrier migration but also exhibited a rare electron backflow effect. The multidimensional synergistic effects conferred upon MCT-X with excellent sensing properties. The optimal MCT-2 exhibited an outstanding response of 450.01 for TEA (100 ppm, 134 °C), along with superior selectivity, linearity, and stability. Density Functional Theory (DFT) calculations reveal in-depth explanation of the anisotropic charge transport mechanism induced by differences in crystal planes contacts and the sensitization mechanism of the heterostructure. This distinctive synthesis approach, combined with comprehensive mechanistic analysis, offers a strategy for the design of advanced TEA sensing materials.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137577"},"PeriodicalIF":8.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outstandingly selective n-butanol gas sensor based on ZnS/NiO lychee-shaped nanospheres

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137573

Yujun Guo , Jiayi Qu , Zhenkai Zhang , Zhenyue Liu , Chen Yue , Qiuying Chen , Zhiguo Yang , Yang Mu , Xiaoning Wang , Davoud Dastan , Xi-Tao Yin , Xiaoguang Ma

In this paper, ZnS/NiO p-n heterojunction microspheres were fabricated via a two-step hydrothermal approach. The sensing properties of composites with different ZnS contents were investigated by regulating the ratio of Zn. When containing 25 mol% ZnS, the ZnS/NiO nanosphere sensor achieved a response of 125. The response was improved by a factor of about 83.3 compared to pure NiO. The sensor functions optimally at a temperature of 225 ℃, and it possesses excellent selectivity, a rapid response/recovery time (49/44 s), and long-term stability. Therefore, this paper provides a hydrothermal method to prepare ZnS/NiO nanocomposites with heterojunction, specifically designed to detect n-butanol. After performing a series of characterizations, it was determined that the enhancement of the gas-sensitive properties could be related to the construction of ZnS/NiO heterojunctions and the increase in oxygen vacancies.

引用次数: 0

Nonelectric syringe pump capable of programmable sequential reagent injection for automated microfluidic device operation

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137553

Minseon Kim , Joong Ho Shin

Microfluidic technology has driven significant progress in clinical diagnostics and point-of-care testing (POCT), with ongoing research investigating its diverse applications. However, a key limitation of microfluidic systems lies in the need for devices and methods to propel the liquids. In this study, we developed a programmable, nonelectric syringe pump capable of delivering multiple reagents to microfluidic devices in a sequential manner. A modular sector gear was designed to selectively cover portions of the gear with teeth, enabling precise and versatile control over the pumping timing. Considering the capabilities and characteristics of the pump, it is named Sequence Modifiable, Automated, and Runtime-Tunable pump, or SMART pump. The pump was utilized to detect Escherichia coli (E. coli) O157:H7, a deadly foodborne pathogen, through a microfluidic-based vertical immunoassay (VFA). In experiments involving the detection of E. coli O157:H7 in milk, the limit of detection (LOD) was determined to be 100 CFU/mL, demonstrating a low detection threshold. This nonelectric, multistep immunoassay automation pump, featuring both portability and automation, is anticipated to be highly suitable for POCT applications. Additionally, its capacity to automate complex assay and detection without relying on an external power source suggests its potential utility in resource-limited environments, thereby improving the accessibility of innovative microfluidics-based assays.

{"title":"Nonelectric syringe pump capable of programmable sequential reagent injection for automated microfluidic device operation","authors":"Minseon Kim , Joong Ho Shin","doi":"10.1016/j.snb.2025.137553","DOIUrl":"10.1016/j.snb.2025.137553","url":null,"abstract":"<div><div>Microfluidic technology has driven significant progress in clinical diagnostics and point-of-care testing (POCT), with ongoing research investigating its diverse applications. However, a key limitation of microfluidic systems lies in the need for devices and methods to propel the liquids. In this study, we developed a programmable, nonelectric syringe pump capable of delivering multiple reagents to microfluidic devices in a sequential manner. A modular sector gear was designed to selectively cover portions of the gear with teeth, enabling precise and versatile control over the pumping timing. Considering the capabilities and characteristics of the pump, it is named Sequence Modifiable, Automated, and Runtime-Tunable pump, or SMART pump. The pump was utilized to detect <em>Escherichia coli</em> (<em>E. coli</em>) O157:H7, a deadly foodborne pathogen, through a microfluidic-based vertical immunoassay (VFA). In experiments involving the detection of <em>E</em>. <em>coli</em> O157:H7 in milk, the limit of detection (LOD) was determined to be 100 CFU/mL, demonstrating a low detection threshold. This nonelectric, multistep immunoassay automation pump, featuring both portability and automation, is anticipated to be highly suitable for POCT applications. Additionally, its capacity to automate complex assay and detection without relying on an external power source suggests its potential utility in resource-limited environments, thereby improving the accessibility of innovative microfluidics-based assays.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137553"},"PeriodicalIF":8.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late-model naphthalene diimide material to construct highly sensitive PEC immunosensor for the detection of CEA 构建用于检测癌胚抗原（CEA）的高灵敏度 PEC 免疫传感器的新型萘二亚胺材料

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137572

Ling-Yu Zhao , Huai-Qing Zhao , Xia Li , Lei Shang , Guo-Dong Shen , Rong-Na Ma , Huai-Sheng Wang

Naphthalene diimides (NDIs) have emerged as key candidates in the realms of photocatalysis and photovoltaics because of their semiconducting properties. However, their potential application in photoelectrochemical (PEC) sensing has yet to be fully explored. In this study, two novel NDI derivatives: 2,2′-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)dipropionic acid (NDI-COOH) and its bromine-substituted counterpart, 2,2′-(4,9-dibromo-1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)dipropionic acid (Br-NDI-COOH) were synthesized and characterized. Theoretical and experimental analyses demonstrated that the bromine substitution significantly enhanced the PEC performance of Br-NDI-COOH by extending its absorption spectrum toward visible light. Furthermore, the integration of gold nanoparticles (AuNPs) with Br-NDI-COOH leads to the formation of an AuNPs/Br-NDI-COOH composite material that significantly enhances the PEC signal, which could be used as a signal probe in PEC immunosensor for the detection of the key biomarker carcinoembryonic antigen (CEA). The constructed sensor exhibits remarkable sensitivity, with a detection limit of 1.22 fg·mL⁻¹ and a linear response ranging from 10 fg·mL⁻¹ to 100 ng·mL⁻¹, which indicate the promising potential of the AuNPs/Br-NDI-COOH platform for the sensitive detection of biomarkers in complex biological matrices. This work pioneered the use of NDIs in PEC immunosensing and highlighted the pivotal role of functional group engineering in optimizing the PEC properties of organic semiconductors.

{"title":"Late-model naphthalene diimide material to construct highly sensitive PEC immunosensor for the detection of CEA","authors":"Ling-Yu Zhao , Huai-Qing Zhao , Xia Li , Lei Shang , Guo-Dong Shen , Rong-Na Ma , Huai-Sheng Wang","doi":"10.1016/j.snb.2025.137572","DOIUrl":"10.1016/j.snb.2025.137572","url":null,"abstract":"<div><div>Naphthalene diimides (NDIs) have emerged as key candidates in the realms of photocatalysis and photovoltaics because of their semiconducting properties. However, their potential application in photoelectrochemical (PEC) sensing has yet to be fully explored. In this study, two novel NDI derivatives: 2,2′-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)dipropionic acid (NDI-COOH) and its bromine-substituted counterpart, 2,2′-(4,9-dibromo-1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)dipropionic acid (Br-NDI-COOH) were synthesized and characterized. Theoretical and experimental analyses demonstrated that the bromine substitution significantly enhanced the PEC performance of Br-NDI-COOH by extending its absorption spectrum toward visible light. Furthermore, the integration of gold nanoparticles (AuNPs) with Br-NDI-COOH leads to the formation of an AuNPs/Br-NDI-COOH composite material that significantly enhances the PEC signal, which could be used as a signal probe in PEC immunosensor for the detection of the key biomarker carcinoembryonic antigen (CEA). The constructed sensor exhibits remarkable sensitivity, with a detection limit of 1.22 fg·mL<sup>−1</sup> and a linear response ranging from 10 fg·mL<sup>−1</sup> to 100 ng·mL<sup>−1</sup>, which indicate the promising potential of the AuNPs/Br-NDI-COOH platform for the sensitive detection of biomarkers in complex biological matrices. This work pioneered the use of NDIs in PEC immunosensing and highlighted the pivotal role of functional group engineering in optimizing the PEC properties of organic semiconductors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137572"},"PeriodicalIF":8.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polychromatic fluorescent sensor for hydrogen sulfate anion recognition based on molecular conformation transformation

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137579

Yifan Wu, Chuanxing Yang, Lu Li, Qiaochun Wang, Zhiyun Zhang, Jianhua Su, Xuanying Chen, Lifang Guo

Detection of hydrogen sulfate anion (HSO₄^-) is becoming crucial in biology, environmental sciences, and catalysis scientific fields. Herein, we demonstrate a strategy for precisely and visually detecting hydrogen sulfate anion (HSO₄^-) by polychromic fluorescence variations based on molecular conformation transformation in the mixed solvent of acetonitrile and water (v/v = 4:1) with the detection limit of 5.08 μM. With the combination of a flexible skeleton of N,N’-diphenyl-dihydrodibenzo[a,c]-phenazine (DPAC) and two recognition ‘claws’ of triazole units, the fluorescent sensor DPAC-Tz was designed and synthesized. Depending on the non-covalent binding affinity of triazole units with hydrogen sulfate anions, the bend-to-twisted conformation evolution of DPAC moiety in the excited state was restricted, resulting in the significant fluorescent color conversion from orange to blue. The non-covalent interaction mode was investigated by ¹H NMR spectroscopic analysis and density functional theory (DFT) calculations as well as IGMH analysis, and the application of DPAC-Tz on hydrogen sulfate anions was demonstrated in the living cells imaging. This study explicitly reveals the application prospect of combining flexible scaffolds with dynamic structural evolution and non-covalent intermolecular interactions for analyte sensing, thereby inspiring the exploitation of polychromatic fluorescent sensors with high selectivity and visibility in various chemical detections.

{"title":"Polychromatic fluorescent sensor for hydrogen sulfate anion recognition based on molecular conformation transformation","authors":"Yifan Wu, Chuanxing Yang, Lu Li, Qiaochun Wang, Zhiyun Zhang, Jianhua Su, Xuanying Chen, Lifang Guo","doi":"10.1016/j.snb.2025.137579","DOIUrl":"10.1016/j.snb.2025.137579","url":null,"abstract":"<div><div>Detection of hydrogen sulfate anion (HSO<sub>4</sub><sup>-</sup>) is becoming crucial in biology, environmental sciences, and catalysis scientific fields. Herein, we demonstrate a strategy for precisely and visually detecting hydrogen sulfate anion (HSO<sub>4</sub><sup>-</sup>) by polychromic fluorescence variations based on molecular conformation transformation in the mixed solvent of acetonitrile and water (v/v = 4:1) with the detection limit of 5.08 μM. With the combination of a flexible skeleton of N,N’-diphenyl-dihydrodibenzo[<em>a</em>,<em>c</em>]-phenazine (<strong>DPAC</strong>) and two recognition ‘claws’ of triazole units, the fluorescent sensor <strong>DPAC-Tz</strong> was designed and synthesized. Depending on the non-covalent binding affinity of triazole units with hydrogen sulfate anions, the bend-to-twisted conformation evolution of <strong>DPAC</strong> moiety in the excited state was restricted, resulting in the significant fluorescent color conversion from orange to blue. The non-covalent interaction mode was investigated by <sup><strong>1</strong></sup><strong>H</strong> NMR spectroscopic analysis and density functional theory (DFT) calculations as well as IGMH analysis, and the application of <strong>DPAC-Tz</strong> on hydrogen sulfate anions was demonstrated in the living cells imaging. This study explicitly reveals the application prospect of combining flexible scaffolds with dynamic structural evolution and non-covalent intermolecular interactions for analyte sensing, thereby inspiring the exploitation of polychromatic fluorescent sensors with high selectivity and visibility in various chemical detections.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"433 ","pages":"Article 137579"},"PeriodicalIF":8.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ag nanoparticles sensitized ZnO/MoS2 composites to detect ppb-level NO2 and automobile exhaust gas

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137569

Hao Huang, Zhiguang Pan, Jing Wang, Tianqi Wang, Wenyuan Yang, Hui Yu, Feng Li, Xiangting Dong, Ying Yang

Increasing car ownership and industrialization will undoubtedly increase the amount of NO₂ in the atmosphere, which is immeasurably harmful to the environment and human body. However, the development of sensors capable of rapidly detecting NO₂ at ppb-level and with excellent resistance to humidity remains a great challenge. Here, we prepared Ag@ZnO/MoS₂ composites by hydrothermal method, photodeposition and calcination at specific temperature. The obtained composites showed a flower-like structure. The gas sensing performance tests showed that the Ag@ZnO/MoS₂ sensor has the highest response to 100 ppm-100 ppb NO₂ at 130 °C, short response/recovery time (2.5/3 s), low theoretical detection limit (36 ppb) and excellent humidity resistance. This may be attributed to the construction of heterojunctions and the catalytic effect of Ag nanoparticles. In addition, we have successfully applied Ag@ZnO/MoS₂ sensor to automobile exhaust gas detection, which provides new insights into the development of portable automobile exhaust gas detection sensors.

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引用次数: 0

A wide dynamic range gas analysis model with deep learning based on cavity ring-down spectroscopy

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-03-05 DOI: 10.1016/j.snb.2025.137575

Ruiwei Tang, Yushuo Song, Huidi Zhang, Sheng Zhou

The cavity ring-down spectroscopy (CRDS) plays an important role in the detection of sensitive gas detection. However, the dynamic range of CRDS-based gas sensors is limited due to the reduced accuracy of the ring-down time and the occurrence of low signal intensity under high gas concentration. To overcome the limitation on the dynamic range, a CNN-assisted CRDS algorithm was proposed for gas sensing, designed to handle low and high-concentration absorption spectra simultaneously. A cavity ring-down spectroscopy gas sensing system was implemented, and CO₂ was selected as the target analyte for evaluating the performance of the constructed CNN-assisted algorithm. It is trained on a dataset including absorption spectra of low and high concentrations. The experimental results indicate the feasibility of using a neural network to assist in processing cavity ring-down spectral signals. The dynamic range of the CNN-assisted CRDS technique exceeds that of the traditional CRDS technique by an order of magnitude, improving from 4000 ppm to 40000 ppm. This method provides a way to expand the application of CRDS, especially for applications that require measuring gas concentrations with significant fluctuations, such as industrial emissions, gas leak detection, and geological hazard monitoring.

空腔降环光谱（CRDS）在灵敏气体检测中发挥着重要作用。然而，基于 CRDS 的气体传感器的动态范围受到限制，原因是环降时间的精度降低，以及在高浓度气体下会出现低信号强度。为了克服动态范围的限制，提出了一种用于气体检测的 CNN 辅助 CRDS 算法，旨在同时处理低浓度和高浓度吸收光谱。实现了一个空腔环向下光谱气体传感系统，并选择二氧化碳作为目标分析物来评估所构建的 CNN 辅助算法的性能。该算法在包括低浓度和高浓度吸收光谱的数据集上进行了训练。实验结果表明，使用神经网络辅助处理空腔环降光谱信号是可行的。CNN 辅助 CRDS 技术的动态范围比传统 CRDS 技术高出一个数量级，从 4000 ppm 提高到 40000 ppm。这种方法为扩大 CRDS 的应用范围提供了一种途径，特别是在需要测量具有明显波动的气体浓度的应用领域，如工业排放、气体泄漏检测和地质灾害监测等。

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引用次数: 0

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