Sensors and Actuators B: Chemical最新文献_第7页

CsPbBr3 quantum dots decorated TiO2 nanofibers for superior ethanolamine detection at room temperature under UV irradiation CsPbBr3量子点修饰TiO2纳米纤维，在室温下紫外辐射下检测乙醇胺

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-28 DOI: 10.1016/j.snb.2026.139567

Miao Liu , Jiyu Shi , Xiao Wang , Mei Yan , Peng Song

Ethanolamine (EA) is a volatile organic compound (VOC) that can pollute the environment and pose a threat to human health, and it is necessary to develop efficient gas sensors for continuous detection of EA vapors. Herein, CsPbBr₃ quantum dots (QDs) with perovskite structure were deposited on the surface of TiO₂ nanofibers (NFs) to prepare TiO₂/CsPbBr₃ heterostructures. The new gas sensor based on TiO₂/CsPbBr₃ composite material achieves rapid and accurate detection of EA at low temperature by capturing photo generated electrons in CsPbBr₃ QDs functionalized TiO₂ NFs. The experimental results indicated that the TiO₂/CsPbBr₃ heterostructure displayed a highest EA-sensing performance under UV irradiation, with a response value of 125.5, which increased the response by a factor of 2.8 and 6.3 times compared with those of TiO₂/CsPbBr₃ composite without UV-excitation and pure TiO₂, respectively. Meanwhile, the UV-excited TiO₂/CsPbBr₃-sensor also possesses high selectivity, excellent cyclic reproducibility, long-term durability, and shortened response/recovery time (7.7/9.3 s). The improved EA-sensitive response by UV activation and CsPbBr₃ QDs modifications might be ascribed to the photo-generated electron transfer and the formation of n-p heterojunctions. The EA-sensing mechanism of TiO₂/CsPbBr₃ composite was explored by density functional theory (DFT) calculation on adsorption characteristic and electronic behavior in detail. The modification of TiO₂ with CsPbBr₃ QDs offers an experimental reference for the development potential in the field of low-temperature EA sensors.

乙醇胺（EA）是一种会污染环境并对人体健康构成威胁的挥发性有机化合物（VOC），有必要开发高效的气体传感器对EA蒸气进行连续检测。本文将具有钙钛矿结构的CsPbBr3量子点（QDs）沉积在TiO2纳米纤维（NFs）表面，制备TiO2/CsPbBr3异质结构。基于TiO2/CsPbBr3复合材料的新型气体传感器通过捕获CsPbBr3量子点官能化TiO2 NFs中的光生电子，实现了低温下快速准确的EA检测。实验结果表明，在UV照射下，TiO2/CsPbBr3异质结构表现出最高的ea感应性能，响应值为125.5，分别比未受UV激发的TiO2/CsPbBr3复合材料和纯TiO2提高了2.8倍和6.3倍。同时，紫外光激发的TiO2/ cspbbr3传感器还具有高选择性、良好的循环重现性、长期耐用性和较短的响应/恢复时间（7.7/9.3 s）。通过UV活化和CsPbBr3 QDs修饰提高ea敏感响应可能归因于光产生的电子转移和n-p异质结的形成。通过密度泛函理论（DFT）计算吸附特性和电子行为，探讨了TiO2/CsPbBr3复合材料的ea传感机理。利用CsPbBr3量子点修饰TiO2，为其在低温EA传感器领域的发展潜力提供了实验参考。

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引用次数: 0

Tunable Selectivity: High-performance detection of NO2 and triethylamine enabled by In2O3-Co3O4 heterojunction nanoflowers 选择性可调：利用In2O3-Co3O4异质结纳米花实现NO2和三乙胺的高效检测

IF 8.4 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-28 DOI: 10.1016/j.snb.2026.139562

Zhidong Jin, Jinbo Zhao, Lin Liu, Fei Liu, Shiqiang Li, Jiurong Liu, Lili Wu

This study presents the synthesis of In₂O₃-Co₃O₄ flower-like microspheres via a two-step method, where the In₂O₃ matrix, composed of ultra-thin nanosheets, serves as a scaffold for the surface dispersion of Co₃O₄. By modulating the Co₃O₄ concentration, two sensors (ICO-1 and ICO-10) were fabricated, demonstrating excellent and distinct selectivity at a low optimal temperature of 100 ℃. Among them, ICO-1 exhibited a high response of 1600 to 10 ppm NO₂, while ICO-10 showed a response of 124.32 to 100 ppm triethylamine (TEA) with tunable selectivity. The sensors as well achieved low theoretical detection limits of 100 ppb for NO₂ and 2.5 ppm for TEA, respectively. Systematic characterization revealed that the switching of selectivity originates from the synergistic effects of heterojunction formation, electron depletion layer modulation, and the tailored concentrations of surface chemisorbed oxygen and oxygen vacancies. This work elucidates a feasible pathway for designing highly sensitive and selectively tunable gas sensors by engineering heterojunction composition in metal-oxide semiconductors.

本研究通过两步法合成了In2O3-Co3O4花状微球，其中由超薄纳米片组成的In2O3基质作为Co3O4表面分散的支架。通过调节Co3O4的浓度，制备了两个传感器（ICO-1和ICO-10），在100 ℃的低最适温度下表现出优异的选择性。其中，ICO-1对1600 ~ 10 ppm NO2具有较高的响应，ICO-10对124.32 ~ 100 ppm三乙胺（TEA）具有可调的选择性。这些传感器也分别达到了NO2 100 ppb和TEA 2.5 ppm的低理论检测限。系统表征表明，选择性的切换源于异质结形成、电子耗尽层调制以及表面化学吸附氧和氧空位的定制浓度的协同效应。这项工作阐明了通过工程设计金属氧化物半导体异质结组成来设计高灵敏度和选择性可调谐气体传感器的可行途径。

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引用次数: 0

Fluorescence and colorimetric dual-mode sensor based on red-emitting chiral carbon dots for discrimination of serine enantiomers and basic amino acids 基于红发手性碳点的荧光比色双模传感器用于丝氨酸对映体和碱性氨基酸的鉴别

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-27 DOI: 10.1016/j.snb.2026.139559

Wencai Wang , Yongbo Wang , Yanting Jia , Shaojie Wang , Yuanna Ning , Jinxuan Yang

Chiral recognition of amino acid enantiomers and discrimination of basic amino acids is critical in detecting disease markers and understanding physiological processes. In this work, chiral carbon dots emitting red fluorescence at 630 nm (R-CCDs) were synthesized via a one-step solvothermal method with L-Valine as the chiral source. The R-CCDs demonstrated excellent enantioselective recognition capabilities toward serine enantiomers (L-Ser and D-Ser) through both fluorescence and colorimetric detection modes. Upon addition of L-Ser, the fluorescence of R-CCDs was progressively quenched, accompanied by a distinct color change from brown to pink, whereas D-Ser induced negligible changes in both. Quantitative detection of L-Ser was further achieved via fluorescence and colorimetric methods, with detection limits of 7.68 μM and 0.71 μM, respectively. The developed methods exhibited excellent applicability in complex biological matrices, with recovery rates ranging from 94.69 % to 117.64 % (RSD < 4 %). The chiral recognition mechanism was systematically investigated through spectral analysis and theoretical calculations. Based on the dual-modal signal response of R-CCDs toward amino acids, a one-component dual-mode sensor array was constructed for discrimination of 3 basic amino acids (100 % accuracy). Moreovre, a portable detection device integrated with a signal readout system was developed for on-site and rapid identification of serine enantiomers. This work presents a facile and efficient strategy for the chiral discrimination of serine enantiomers and holds promise for the detection of other chiral bioactive molecules.

氨基酸对映体的手性识别和碱性氨基酸的区分对于检测疾病标志物和理解生理过程至关重要。本文以l -缬氨酸为手性源，采用一步溶剂热法合成了发射630 nm红色荧光的手性碳点（r - ccd）。通过荧光和比色检测模式，r - ccd对丝氨酸对映体（l -丝氨酸和d -丝氨酸）表现出优异的对映选择性识别能力。加入L-Ser后，r - ccd的荧光逐渐猝灭，并伴有明显的从棕色到粉红色的颜色变化，而D-Ser对两者的变化都可以忽略不计。采用荧光法和比色法对L-Ser进行定量检测，检出限分别为7.68 μM和0.71 μM。该方法在复杂的生物基质中具有良好的适用性，回收率为94.69 % ~ 117.64 % （RSD < 4 %）。通过光谱分析和理论计算，系统地研究了手性识别机理。基于r - ccd对氨基酸的双模信号响应，构建了一个单组分双模传感器阵列，用于3种碱性氨基酸的识别（准确度为100% %）。此外，开发了一种集成信号读出系统的便携式检测装置，用于丝氨酸对映体的现场快速鉴定。这项工作为丝氨酸对映体的手性鉴别提供了一种简单有效的策略，并有望用于其他手性生物活性分子的检测。

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引用次数: 0

Early detection of necrotizing enterocolitis via a hypochlorous acid biosensor tracking pathological signals 利用次氯酸生物传感器追踪病理信号，早期发现坏死性小肠结肠炎

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-27 DOI: 10.1016/j.snb.2026.139558

Biao Gu , Yaqian Li , Zefeng Zheng , Boyou Zhang , Jing Liu , Yuebai Zhang , Wei Shi , Jinfa Tou , Dengming Lai , Dandan Wang , Jingjun Zhao , Ruiqing Long , Yongjie Liu , Qiang Shu , Lijia Wang

Necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality among preterm neonates. However, the timely diagnosis of NEC is hindered by the lack of reliable biomarkers. A key pathogenic feature of NEC is the overproduction of hypochlorous acid (HClO) by activated neutrophils and macrophages via the MPO-H₂O₂-Cl⁻ system. Therefore, the development of robust HClO detection tools is crucial for the early diagnosis of NEC. In this study, a novel near-infrared (NIR) fluorescent probe (Cy-1) was developed to monitor HClO, with the aim of enabling early NEC diagnosis. Cy-1 displayed high sensitivity and selectivity toward HClO with a rapid response (40 s), and was capable of detecting both exogenous and endogenous HClO in living cells. Using this probe, we successfully tracked dynamic changes in HClO levels during the cisplatin-induced apoptosis. Furthermore, in vivo fluorescence imaging showed significantly increased fluorescence signals in NEC model mice after Cy-1 administration. This work demonstrated the great potential of Cy-1 as a powerful tool for investigating HClO-associated apoptotic processes, as well as a promising candidate for the early clinical diagnosis of NEC.

坏死性小肠结肠炎（NEC）仍然是早产儿发病率和死亡率的主要原因。然而，由于缺乏可靠的生物标志物，NEC的及时诊断受到阻碍。NEC的一个关键致病特征是活化的中性粒细胞和巨噬细胞通过MPO-H2O2-Cl -毒血症系统产生过量的次氯酸（HClO）。因此，开发强大的HClO检测工具对于NEC的早期诊断至关重要。在本研究中，开发了一种新型近红外（NIR）荧光探针（Cy-1）来监测HClO，目的是实现NEC的早期诊断。Cy-1对HClO具有较高的敏感性和选择性，反应速度快（40 s），能够检测活细胞中的外源性和内源性HClO。利用该探针，我们成功地追踪了顺铂诱导的细胞凋亡过程中HClO水平的动态变化。此外，体内荧光成像显示Cy-1给药后NEC模型小鼠荧光信号明显增加。这项工作证明了Cy-1作为研究hcl相关凋亡过程的强大工具的巨大潜力，以及NEC早期临床诊断的有希望的候选者。

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引用次数: 0

Multifunctional fluorescence probe for detecting viscosity, ONOO– and polarity in vitro and vivo with three channels 多功能荧光探针，用于检测黏度、ONOO和极性的体外和体内三通道

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-27 DOI: 10.1016/j.snb.2026.139556

Ya-Jing Shang , Xing-Hu Wu , Jun-Tao Niu , Chen-Chen Li , Ai-Hong Zhang , Xiao-Lei Zhang , Xu-Ying Liu , Ting Liang , Yan-Fei Kang

The cellular microenvironment (viscosity and polarity) and ONOO^- play significant effects on the maintenance of redox balance, signal transmission, and normal cell operation, even closely associated to the onset of various diseases. Therefore, we designed and synthesized the targeted mitochondrial probe (VNP-M) featuring three distinct switch-on modes for detecting viscosity, ONOO^- and polarity. The emission spectrum of VNP-M displayed remarkable response for viscosity at 680 nm and ONOO^- at 580 nm, respectively. Meanwhile, there was a satisfying correspondence between the area under curve (AUC) of 454–654 nm and the polarity. The fluorescence change mechanism was elaborated in detail by theoretical calculation. The VNP-M showed excellent bioimage application ability for confirmation of cancer cells and diabetes diagnosis in vitro and in vivo. More importantly, leveraging VNP-M, we confirmed for the first time that metformin can alleviate diabetes by inhibiting ferroptosis via the detection of viscosity, polarity and ONOO^-. Therefore, the VNP-M provided a potential tool for exploring disease status and process through simultaneous measure of viscosity, ONOO^- and polarity in mitochondria with three-channel.

细胞微环境（粘度和极性）和ONOO-对氧化还原平衡的维持、信号的传递和细胞的正常运作起着重要的作用，甚至与各种疾病的发生密切相关。因此，我们设计并合成了靶向线粒体探针（VNP-M），该探针具有三种不同的开关模式，用于检测粘度，ONOO-和极性。VNP-M和ONOO-分别在680 nm和580 nm处对黏度有显著响应。同时，454 ~ 654 nm的曲线下面积（AUC）与极性有较好的对应关系。通过理论计算详细阐述了荧光变化机理。在体外和体内实验中，VNP-M在肿瘤细胞确认和糖尿病诊断方面表现出良好的生物图像应用能力。更重要的是，利用VNP-M，我们首次通过检测黏度、极性和ONOO-，证实了二甲双胍可以通过抑制铁下垂来缓解糖尿病。因此，VNP-M通过同时测量三通道线粒体的粘度、ONOO-和极性，为探索疾病状态和过程提供了潜在的工具。

{"title":"Multifunctional fluorescence probe for detecting viscosity, ONOO– and polarity in vitro and vivo with three channels","authors":"Ya-Jing Shang , Xing-Hu Wu , Jun-Tao Niu , Chen-Chen Li , Ai-Hong Zhang , Xiao-Lei Zhang , Xu-Ying Liu , Ting Liang , Yan-Fei Kang","doi":"10.1016/j.snb.2026.139556","DOIUrl":"10.1016/j.snb.2026.139556","url":null,"abstract":"<div><div>The cellular microenvironment (viscosity and polarity) and ONOO<sup>-</sup> play significant effects on the maintenance of redox balance, signal transmission, and normal cell operation, even closely associated to the onset of various diseases. Therefore, we designed and synthesized the targeted mitochondrial probe (<strong>VNP</strong>-<strong>M</strong>) featuring three distinct switch-on modes for detecting viscosity, ONOO<sup>-</sup> and polarity. The emission spectrum of <strong>VNP</strong>-<strong>M</strong> displayed remarkable response for viscosity at 680 nm and ONOO<sup>-</sup> at 580 nm, respectively. Meanwhile, there was a satisfying correspondence between the area under curve (AUC) of 454–654 nm and the polarity. The fluorescence change mechanism was elaborated in detail by theoretical calculation. The <strong>VNP</strong>-<strong>M</strong> showed excellent bioimage application ability for confirmation of cancer cells and diabetes diagnosis in vitro and in vivo. More importantly, leveraging <strong>VNP</strong>-<strong>M</strong>, we confirmed for the first time that metformin can alleviate diabetes by inhibiting ferroptosis via the detection of viscosity, polarity and ONOO<sup>-</sup>. Therefore, the <strong>VNP</strong>-<strong>M</strong> provided a potential tool for exploring disease status and process through simultaneous measure of viscosity, ONOO<sup>-</sup> and polarity in mitochondria with three-channel.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"453 ","pages":"Article 139556"},"PeriodicalIF":3.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An acetylcholinesterase-activated near-infrared frequency upconversion luminescence probe for real-time imaging of oxidative stress-regulated acetylcholinesterase dynamics 一种用于氧化应激调节的乙酰胆碱酯酶动态实时成像的近红外频率上转换发光探针

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-26 DOI: 10.1016/j.snb.2026.139557

Qingchun Lan, Shuqin Fang, Shufen Pan, Xi Chen, Zhibo Zuo, Ling Zhu, Yongquan Wu

We present a rationally engineered near-infrared frequency upconversion luminescence (FUCL) probe, termed PT-2, specifically designed for the selective detection of acetylcholinesterase (AChE) activity in biological systems. This probe incorporates an optimised molecular architecture that combines an oxadiazole-benzothiazole fluorophore with a cyclopropylformate enzymatic trigger, facilitating AChE-specific activation via hydrolysis-mediated intramolecular charge transfer (ICT) switching. PT-2 demonstrates superior sensing properties, rapid activation kinetics, dual-mode fluorescence (FL) and FUCL detection with enhanced FUCL sensitivity (0.22 mU/mL), and exceptional selectivity against biological interferents. In cellular studies, PT-2 revealed that glutamate-induced oxidative stress progressively upregulates AChE expression. Importantly, in vivo investigations enabled differential quantification of exogenous and endogenous AChE in murine models, capturing both inhibitor-mediated suppression and stress-induced activation of enzymatic activity. This work introduces a versatile imaging tool for real-time tracking of AChE pathophysiology and provides mechanistic insights that establish AChE as a mediator of oxidative stress in neurological disorders, thereby advancing diagnostic methodologies for neurodegeneration.

我们提出了一种合理设计的近红外频率上转换发光（FUCL）探针，称为PT-2，专门用于生物系统中乙酰胆碱酯酶（AChE）活性的选择性检测。该探针采用优化的分子结构，结合了恶二唑-苯并噻唑荧光基团和环丙基甲酸酶触发器，通过水解介导的分子内电荷转移（ICT）开关促进ache特异性激活。PT-2具有优异的传感特性，快速的激活动力学，双模式荧光（FL）和FUCL检测，FUCL灵敏度提高（0.22 mU/mL），对生物干扰具有卓越的选择性。在细胞研究中，PT-2显示谷氨酸诱导的氧化应激逐渐上调乙酰胆碱酯酶的表达。重要的是，体内研究在小鼠模型中实现了外源性和内源性AChE的差异量化，捕获了抑制剂介导的抑制和应激诱导的酶活性激活。这项工作引入了一种多功能成像工具，用于实时跟踪AChE病理生理，并提供了建立AChE作为神经系统疾病氧化应激介质的机制见解，从而推进了神经退行性疾病的诊断方法。

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引用次数: 0

Phosphate ion-selective electrode based on a cyclic polyamine ionophore for soil analysis 基于环多胺离子载体的磷离子选择电极用于土壤分析

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-26 DOI: 10.1016/j.snb.2026.139555

Sebin Oh , Jiyeon Ha , Hyen Chung Chun , In Tae Kim , Yang-Rae Kim

Rapid and accurate monitoring of soil phosphorus is crucial for precision agriculture. Unfortunately, conventional methods such as ion chromatography (IC) and inductively coupled plasma-optical emission spectrometry (ICP-OES) are limited by complex sample preparation requirements and long analysis times. To address these issues, we developed a polymeric membrane ion-selective electrode (ISE) for selective detection of dihydrogen phosphate (H₂PO₄⁻) using a newly synthesized cyclic polyamine ionophore, 3-(9-decenyl)-1,5,8-triazacyclodecane-2,4-dione. The optimized ISE exhibited near-Nernstian sensitivity across a wide concentration range (6.76 × 10⁻⁶–6.76 × 10⁻² M) and a detection limit of 4.60 × 10⁻⁶ at pH 6.5. High selectivity was achieved without lipophilic additives, and the ISE maintained its excellent performance over the pH range of 5.5–8.0. When applied to soil extraction solutions from a corn field and horticultural mixed culture soil, the ISE showed good agreement with IC and ICP-OES while enabling continuous monitoring over 13 d. Temporal dynamics of phosphate ions not previously detected by conventional methods were also revealed. The ISE offers rapid responses, minimal sample preparation, and in situ monitoring, making it a practical alternative for field-based phosphate ion monitoring in precision agriculture and environmental management.

快速准确的土壤磷监测对精准农业至关重要。不幸的是，传统的方法，如离子色谱（IC）和电感耦合等离子体光学发射光谱（ICP-OES）受到复杂的样品制备要求和较长的分析时间的限制。为了解决这些问题，我们开发了一种聚合物膜离子选择电极（ISE），用于选择性检测磷酸二氢（H2PO4−），使用新合成的环多胺离子载体，3-（9-癸基）-1,5,8-三氮杂环癸烷-2,4-二酮。优化后的ISE在较宽的浓度范围内（6.76 × 10−6 - 6.76 × 10−2 M）具有接近能斯特的灵敏度，在pH 6.5时检测限为4.60 × 10−6。在不添加亲脂性添加剂的情况下，ISE具有较高的选择性，且在5.5 ~ 8.0的pH范围内均保持了良好的性能。当应用于玉米田和园艺混合栽培土壤的土壤提取溶液时，ISE与IC和ICP-OES表现出良好的一致性，同时能够连续监测超过13 d。磷酸盐离子的时间动态也揭示了以前传统方法无法检测到的。ISE提供快速响应，最少的样品制备和现场监测，使其成为精准农业和环境管理中基于现场的磷酸盐离子监测的实用替代方案。

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引用次数: 0

Proximity ligation dependent immuno-PCR assay for sub-pg/mL quantification of protein biomarker 蛋白生物标志物亚pg/mL定量的近端连接依赖免疫pcr检测

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-26 DOI: 10.1016/j.snb.2026.139551

Rongkai Cai , Ziying Xu , Juan Deng , Kaimin Wang , Danyu Tian , Yilin Yan , Fenyong Sun , Qingzhong Liu

Sensitive detection of low-abundance proteins is essential for early disease diagnosis, yet conventional chemiluminescent immunoassays rarely achieve the required limits. Signal transduction from proteins to DNA offers a solution, as seen in immuno-PCR (IPCR) and proximity ligation assay (PLA). However, IPCR suffers from adsorption-induced background, while PLA is prone to ligation of free unbound probes. Here we demonstrate the Proximity Ligation Dependent Immuno-PCR Assay (PRIPA), which establishes a generalizable solid-phase proximity ligation framework that strictly permits ligation only after antigen-verified, surface-confined binding. Split-DNA reporters effectively resolve IPCR’s nonspecific adsorption background, whereas stringent wash steps suppress the free-probe ligation events typical of PLA, collectively reducing false signals and enhancing robustness. To demonstrate this design in a clinically meaningful context, PRIPA was applied to quantify plasma p-tau¹⁸¹. Using three anchoring strategies, PRIPA achieved a detection limit of 0.024 pg/mL and a linear range of 0.064 – 1000 pg/mL. Plasma spike-and-recovery experiments yielded 99.2–108.4 %, and specificity tests confirmed strong discrimination against non-target proteins (P < 0.001). These results establish PRIPA as a robust and widely applicable analytical platform for reliable sub-pg/mL protein quantification, with p-tau¹⁸¹ serving as a clinically meaningful demonstration of its potential in Alzheimer’s disease detection.

低丰度蛋白的敏感检测对于早期疾病诊断至关重要，但传统的化学发光免疫测定法很少达到所需的限度。从蛋白质到DNA的信号转导提供了一种解决方案，如免疫pcr （IPCR）和接近结扎试验（PLA）所见。然而，IPCR受到吸附诱导背景的影响，而PLA容易被游离的未结合探针结扎。在这里，我们展示了邻近连接依赖免疫pcr测定（PRIPA），它建立了一个通用的固相邻近连接框架，严格允许连接后，抗原验证，表面限制的结合。分裂- dna报告器有效地解决了IPCR的非特异性吸附背景，而严格的洗涤步骤抑制了PLA典型的自由探针连接事件，共同减少了虚假信号并增强了鲁棒性。为了在临床有意义的情况下证明这一设计，应用PRIPA定量血浆p-tau181。通过三种锚定策略，PRIPA的检出限为0.024pg/mL，线性范围为0.064 ~ 1000pg/mL。血浆峰回收率为99.2-108.4%，特异性试验证实了对非靶蛋白的强烈区分（P < 0.001）。这些结果表明，PRIPA是一个可靠的亚pg/mL蛋白定量分析平台，p-tau181在阿尔茨海默病检测中具有临床意义。

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引用次数: 0

Integration of click ligation chain reaction with split DNAzyme for enzyme-free cascade amplification and ultrasensitive nucleic acid detection 链接链反应与分裂DNAzyme的集成用于无酶级联扩增和超灵敏核酸检测

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-26 DOI: 10.1016/j.snb.2026.139550

Fan Wang , Chenglong Bao , Susu Cui , Yongsheng Yu , Weiwei Yang

Nucleic acid-templated click ligation offers a powerful enzyme-free amplification route for nucleic acid detection with high specificity and simplicity. However, achieving rapid, low-cost, portable, and ultrasensitive detection remains challenging. Herein, we develop an enzyme-free cascade amplification system, nucleic acid-templated split DNAzyme click ligation chain reaction (NA-SpDzyme-CLCR), by rationally integrating Cu₂O-catalyzed nucleic acid-templated click ligation chain reaction with a split Mg^2 + -dependent DNAzyme for ultrasensitive nucleic acid detection. In this system, target-triggered ligation products undergo covalent reassembly to form catalytically active DNAzymes, which exhibit robust recycling cleavage with high single turnover (k_obs.s = 0.94 ± 0.07 min⁻¹) and multiple turnover (k_obs.m = 0.37 ± 0.02 min⁻¹) numbers, enabling efficient secondary signal amplification. As a proof of concept, we established fluorescence and lateral flow strip assays using the NA-SpDzyme-CLCR system, achieving detection limits of 0.3 aM (fluorescence) and 2 aM (visual), while exhibiting excellent specificity in discriminating single-base mismatches and reliable performance in complex biological matrices. Furthermore, these assays enable versatile detection of the target of interest by customizing the probe recognition sequences. Benefiting from its enzyme-free, high sensitivity, versatility, and compatibility, the NA-SpDzyme-CLCR provides a robust platform for low-abundance biomarker detection and holds great promise for point-of-care diagnostics.

核酸模板点击结扎为核酸检测提供了一种强大的无酶扩增途径，具有高特异性和简便性。然而，实现快速、低成本、便携和超灵敏的检测仍然具有挑战性。本文通过将cu20催化的核酸模板化裂解DNAzyme点击连接链反应与Mg2+依赖的裂解DNAzyme合理整合，构建了一种无酶级联扩增系统——核酸模板化裂解DNAzyme点击连接链反应（NA-SpDzyme-CLCR），用于超灵敏核酸检测。在该系统中，靶触发的连接产物经过共价重组形成具有催化活性的DNAzymes，其具有高单次周转率（kobs），表现出强大的再循环裂解。S = 0.94±0.07min-1)；M = 0.37±0.02min-1)数，实现高效的二次信号放大。为了验证这一概念，我们使用NA-SpDzyme-CLCR系统建立了荧光和横向流动条带分析，检测限分别为0.3 aM（荧光）和2 aM（视觉），同时在区分单碱基错配方面表现出出色的特异性，在复杂的生物基质中表现可靠。此外，通过定制探针识别序列，这些检测能够对感兴趣的目标进行通用检测。得益于其无酶、高灵敏度、多功能性和兼容性，NA-SpDzyme-CLCR为低丰度生物标志物检测提供了一个强大的平台，并为即时诊断提供了巨大的希望。

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引用次数: 0

MVSP-SACFormer: A mixed gas identification method under low- resource conditions MVSP-SACFormer：一种低资源条件下的混合气体识别方法

IF 3.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2026-01-26 DOI: 10.1016/j.snb.2026.139554

Renwei Guan , Kailin Zhang , Hanzhe Liu , Jianbo Li , Ziwen Wang , Xinxin Sun , Jingli Feng , Yan Li , Xuyang Zhu , Ju Zhang

Inspired by the mammalian olfactory system, electronic nose (e-nose) technology has been widely applied in environmental monitoring, food safety, and medical diagnostics. However, mixed gas identification still faces two challenges. Firstly, the gas sensor array exhibits significant cross-sensitivity and low selectivity, resulting in highly overlapped responses among different gases, with redundant features masking key discriminative information. This leads to a sparse and undefined decision space. Secondly, in practical applications, e-nose systems often suffer from limited training samples, making existing methods unstable under low-resource conditions. To solve these problems, this paper proposes MVSP-SACFormer, a mixed gas identification framework tailored for low-resource situations. In the feature extraction phase, we design a Multi-View Subspace Projection Encoding (MVSP) mechanism, which maps raw sensor responses into multiple low-dimensional subspaces via independent random observation matrices, generating compressed features that are structurally diverse and information-complementary. This enhances feature expressiveness under low resource. In the modeling phase, we construct a Spectral-Aware Convolutional Transformer (SACFormer) that fuses spectral, dynamic temporal, and spatial structural features to deeply model the key patterns within complex mixed gas responses. Experiments on two public mixed gas datasets demonstrate that MVSP-SACFormer achieves outstanding recognition performance even when using only 40 % of the training data: achieving 98.03 % classification accuracy on a methane–ethylene mixture dataset, and 97.06 % on an ethylene–carbon monoxide mixture dataset. These results validate that the proposed method serves as a universal pattern recognition framework for e-nose systems under low-resource conditions.

受哺乳动物嗅觉系统的启发，电子鼻技术在环境监测、食品安全、医疗诊断等领域得到了广泛的应用。然而，混合气的识别仍然面临着两个挑战。首先，气体传感器阵列具有显著的交叉灵敏度和低选择性，导致不同气体之间的响应高度重叠，冗余特征掩盖了关键的判别信息。这将导致稀疏且未定义的决策空间。其次，在实际应用中，电子鼻系统经常受到训练样本有限的影响，使得现有方法在低资源条件下不稳定。为了解决这些问题，本文提出了MVSP-SACFormer，这是一种针对低资源情况量身定制的混合气体识别框架。在特征提取阶段，我们设计了一种多视图子空间投影编码（MVSP）机制，该机制通过独立的随机观测矩阵将原始传感器响应映射到多个低维子空间中，生成结构多样且信息互补的压缩特征。这增强了低资源下的特性表现力。在建模阶段，我们构建了一个光谱感知卷积变压器（SACFormer），它融合了光谱、动态时间和空间结构特征，以深入模拟复杂混合气体响应中的关键模式。在两个公共混合气体数据集上的实验表明，即使只使用40%的训练数据，MVSP-SACFormer也取得了出色的识别性能：在甲烷-乙烯混合物数据集上实现了98.03%的分类准确率，在乙烯-一氧化碳混合物数据集上实现了97.06%的分类准确率。结果表明，该方法可作为低资源条件下电子鼻系统的通用模式识别框架。

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