Sensors and Actuators B: Chemical最新文献_第5页

An ultra-high response humidity sensor based on porous boron nitride nanofibers: For respiratory monitoring and non-contact sensing

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-03 DOI: 10.1016/j.snb.2025.137744

Shuqiao Zhang , Jing Lin , Chao Yu , Zhonglu Guo , Chengchun Tang , Yang Huang

Advanced humidity sensors with high response and fast response/recovery time are crucial for environmental and real-time respiratory monitoring applications. Porous boron nitride nanofibers (BNNFs), characterized by high specific surface area, small diameters, non-toxicity, and excellent thermal and chemical stability, have emerged as a promising material for developing advanced humidity sensors. Herein, a humidity sensor utilizing porous BNNFs as a novel humidity-sensitive material has been demonstrated. The sensor exhibits ultra-high response (seven orders of magnitude change), wide humidity detection range (11 % to 93 % RH), fast response/recovery time (1.03 s/4.67 s) (measured as the relative humidity is changed between 11 % and 93 %), and excellent repeatability and selectivity. The porous BNNFs possess high specific surface area and abundant micro/mesopores, which provide active sites and transport channels for efficient water molecules transfer and dispersion. Concurrently, their hydrophilic functional groups enable rapid adsorption through hydrogen bonding, collectively contributing to enhanced sensor performance. Given the remarkable sensing properties, the porous BNNFs humidity sensor has been successfully applied in respiratory monitoring and non-contact sensing. The test results demonstrate that the sensor can accurately achieve real-time monitoring of 63 min⁻¹ high-frequency breaths and distinguish between different breathing patterns under varying physiological states. Additionally, the sensor exhibits a pronounced responsiveness to millimeter-scale variations in fingertip distance. These results highlight its potential for non-contact health monitoring systems and next-generation high-precision respiratory monitoring sensors.

{"title":"An ultra-high response humidity sensor based on porous boron nitride nanofibers: For respiratory monitoring and non-contact sensing","authors":"Shuqiao Zhang , Jing Lin , Chao Yu , Zhonglu Guo , Chengchun Tang , Yang Huang","doi":"10.1016/j.snb.2025.137744","DOIUrl":"10.1016/j.snb.2025.137744","url":null,"abstract":"<div><div>Advanced humidity sensors with high response and fast response/recovery time are crucial for environmental and real-time respiratory monitoring applications. Porous boron nitride nanofibers (BNNFs), characterized by high specific surface area, small diameters, non-toxicity, and excellent thermal and chemical stability, have emerged as a promising material for developing advanced humidity sensors. Herein, a humidity sensor utilizing porous BNNFs as a novel humidity-sensitive material has been demonstrated. The sensor exhibits ultra-high response (seven orders of magnitude change), wide humidity detection range (11 % to 93 % RH), fast response/recovery time (1.03 s/4.67 s) (measured as the relative humidity is changed between 11 % and 93 %), and excellent repeatability and selectivity. The porous BNNFs possess high specific surface area and abundant micro/mesopores, which provide active sites and transport channels for efficient water molecules transfer and dispersion. Concurrently, their hydrophilic functional groups enable rapid adsorption through hydrogen bonding, collectively contributing to enhanced sensor performance. Given the remarkable sensing properties, the porous BNNFs humidity sensor has been successfully applied in respiratory monitoring and non-contact sensing. The test results demonstrate that the sensor can accurately achieve real-time monitoring of 63 min<sup>−1</sup> high-frequency breaths and distinguish between different breathing patterns under varying physiological states. Additionally, the sensor exhibits a pronounced responsiveness to millimeter-scale variations in fingertip distance. These results highlight its potential for non-contact health monitoring systems and next-generation high-precision respiratory monitoring sensors.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137744"},"PeriodicalIF":8.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel NIR absorption and emission probe for imaging of RNA dynamics in live cells and tumor models 用于活细胞和肿瘤模型中 RNA 动态成像的新型近红外吸收和发射探针

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-03 DOI: 10.1016/j.snb.2025.137732

Shumei Huang , Xiaomeng Du , Zhenxin Lin , Gang Chen , Yin Jiang , Wenhui You , Shen Zeng , Huatang Zhang

This study presents the development of a novel RNA-targeted fluorescent probe, O-698, for real-time imaging of RNA in living cells and tumor models. O-698 exhibits significant RNA sensitivity with low cytotoxicity and strong near-infrared (NIR) fluorescence. Subcellular localization studies demonstrated that O-698 selectively binds to RNA in nucleoli and cytoplasm, with minimal overlap with other organelle markers, and outperforms existing commercial RNA probes in terms of specificity and intensity. Furthermore, O-698 demonstrated exceptional stability in cells, maintaining fluorescence for over 8 h, and was effective in monitoring RNA dynamics in response to RNA polymerase inhibition. Upon binding with RNA, O-698 offers a high signal-to-noise ratio for precise visualization without the need for wash steps. In 3D multicellular tumor spheroids, O-698 demonstrated robust penetration and uniform distribution throughout the tumor-like mass, reflecting its excellent capability to diffuse in dense biological tissues. In vivo imaging in tumor-bearing mice revealed strong fluorescence signals at the tumor injection site, consistent with the deep imaging capability of O-698. These findings underscore the potential of O-698 as a powerful tool for studying RNA dynamics in both cellular and in vivo environments. Overall, the rapid, stable, and wash-free imaging capabilities of O-698 make it a promising probe for real-time monitoring of RNA behavior, providing valuable insights into drug mechanisms and therapeutic efficacy.

{"title":"A novel NIR absorption and emission probe for imaging of RNA dynamics in live cells and tumor models","authors":"Shumei Huang , Xiaomeng Du , Zhenxin Lin , Gang Chen , Yin Jiang , Wenhui You , Shen Zeng , Huatang Zhang","doi":"10.1016/j.snb.2025.137732","DOIUrl":"10.1016/j.snb.2025.137732","url":null,"abstract":"<div><div>This study presents the development of a novel RNA-targeted fluorescent probe, <strong>O-698</strong>, for real-time imaging of RNA in living cells and tumor models. <strong>O-698</strong> exhibits significant RNA sensitivity with low cytotoxicity and strong near-infrared (NIR) fluorescence. Subcellular localization studies demonstrated that <strong>O-698</strong> selectively binds to RNA in nucleoli and cytoplasm, with minimal overlap with other organelle markers, and outperforms existing commercial RNA probes in terms of specificity and intensity. Furthermore, <strong>O-698</strong> demonstrated exceptional stability in cells, maintaining fluorescence for over 8 h, and was effective in monitoring RNA dynamics in response to RNA polymerase inhibition. Upon binding with RNA, <strong>O-698</strong> offers a high signal-to-noise ratio for precise visualization without the need for wash steps. In 3D multicellular tumor spheroids, <strong>O-698</strong> demonstrated robust penetration and uniform distribution throughout the tumor-like mass, reflecting its excellent capability to diffuse in dense biological tissues. In vivo imaging in tumor-bearing mice revealed strong fluorescence signals at the tumor injection site, consistent with the deep imaging capability of <strong>O-698</strong>. These findings underscore the potential of <strong>O-698</strong> as a powerful tool for studying RNA dynamics in both cellular and in vivo environments. Overall, the rapid, stable, and wash-free imaging capabilities of <strong>O-698</strong> make it a promising probe for real-time monitoring of RNA behavior, providing valuable insights into drug mechanisms and therapeutic efficacy.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137732"},"PeriodicalIF":8.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Target-responsive DNAzyme hydrogel reinforced by click reaction for surface enhanced Raman scattering detection of okadaic acid

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-03 DOI: 10.1016/j.snb.2025.137756

Ming Wang, Lizhen Zhao, Yuling Hu, Gongke Li

Shellfish toxins are common marine toxins that have attracted worldwide attention due to their serious threats to food safety and human health. In this work, DNA hydrogel based on rolling circle amplification (RCA) and click reaction was developed for surface enhanced Raman scattering (SERS) detection of okadaic acid (OA) combined with target-responsive DNAzyme signal amplification. The RCA strands containing azido-dCTP were combined with cross-linked strands with ethynyl groups via click reaction to form a DNA hydrogel framework. The click reaction strengthened the DNA hydrogel network, making it more rigid and easier to manipulate during the detection process. The aptamer and DNAzyme were introduced into the DNA hydrogel as functionalized DNA components. Upon the specific recognition of OA by the aptamer, the DNAzyme released via the displacement reaction would continuously cleave the enzyme cutting site within the substrate strand to liberate the SERS signal tag. The functionalized DNA hydrogel concurrently achieved the functions of target recognition, signal conversion and signal amplification. Under optimal conditions, this strategy could detect OA with limits of detection as low as 0.2 nmol/L within 30 min. The SERS signal intensity showed good linear relationship with OA concentration in the range of 1.0–300.0 nmol/L. The practical application was validated for detecting trace amounts of OA in aquatic product samples. The stable DNA hydrogel combined with target-responsive DNAzyme signal amplification offers a universal strategy for rapid detection of trace toxins in complex matrixes.

{"title":"Target-responsive DNAzyme hydrogel reinforced by click reaction for surface enhanced Raman scattering detection of okadaic acid","authors":"Ming Wang, Lizhen Zhao, Yuling Hu, Gongke Li","doi":"10.1016/j.snb.2025.137756","DOIUrl":"10.1016/j.snb.2025.137756","url":null,"abstract":"<div><div>Shellfish toxins are common marine toxins that have attracted worldwide attention due to their serious threats to food safety and human health. In this work, DNA hydrogel based on rolling circle amplification (RCA) and click reaction was developed for surface enhanced Raman scattering (SERS) detection of okadaic acid (OA) combined with target-responsive DNAzyme signal amplification. The RCA strands containing azido-dCTP were combined with cross-linked strands with ethynyl groups via click reaction to form a DNA hydrogel framework. The click reaction strengthened the DNA hydrogel network, making it more rigid and easier to manipulate during the detection process. The aptamer and DNAzyme were introduced into the DNA hydrogel as functionalized DNA components. Upon the specific recognition of OA by the aptamer, the DNAzyme released via the displacement reaction would continuously cleave the enzyme cutting site within the substrate strand to liberate the SERS signal tag. The functionalized DNA hydrogel concurrently achieved the functions of target recognition, signal conversion and signal amplification. Under optimal conditions, this strategy could detect OA with limits of detection as low as 0.2 nmol/L within 30 min. The SERS signal intensity showed good linear relationship with OA concentration in the range of 1.0–300.0 nmol/L. The practical application was validated for detecting trace amounts of OA in aquatic product samples. The stable DNA hydrogel combined with target-responsive DNAzyme signal amplification offers a universal strategy for rapid detection of trace toxins in complex matrixes.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137756"},"PeriodicalIF":8.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total antioxidant capacity assessment and accurate quantification of ascorbic acid and glutathione utilizing the enhanced multi-mimetic of Cu-CeO₂ NPs decorated PCN-224

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-02 DOI: 10.1016/j.snb.2025.137709

Yani Liu , Haoyu Chen , Lin Chai , Jing Liu , Shu Huang , Feng Liu , Xiaohua Zhu , Youyu Zhang , Meiling Liu , Shouzhuo Yao

The emergence of various nanozymes has revolutionized approaches to detecting total antioxidant capacity (TAC) in food and biological samples; however, the precise quantification of specific antioxidant species such as ascorbic acid (AA) and glutathione (GSH) continue to present significant challenges. Inspired by the functional characteristics of oxidoreductases, we have developed Cu-CeO₂ nanoparticles adorned PCN-224, which exhibit multiple mimetic behaviors, including oxidase (OXD), ascorbate oxidase (AAO), and glutathione peroxidase (GPx)-like activities. This innovative PCN-224@Cu-CeO₂ is designed for the quantitative evaluation of TAC in food, pharmaceuticals, and biological samples. Simultaneously, it enables the accurate determination of AA and GSH levels with favorable selectivity. The integration of nanozymes onto metal-organic frameworks significantly enhances both stability and catalytic efficiency. Furthermore, utilizing the multi-mimetics activity of the same materials simplifies the biosensing processes for TAC and individual antioxidants in tablets, beverages, fruits, and cells, thereby considerably diminishing experimental intricacy. Our findings not only advance the development and applications of novel nanozymes with exceptional multi-mimetic properties but also tackle selectivity challenges associated with colorimetric detection platforms that rely on oxidase and peroxidase activities.

{"title":"Total antioxidant capacity assessment and accurate quantification of ascorbic acid and glutathione utilizing the enhanced multi-mimetic of Cu-CeO₂ NPs decorated PCN-224","authors":"Yani Liu , Haoyu Chen , Lin Chai , Jing Liu , Shu Huang , Feng Liu , Xiaohua Zhu , Youyu Zhang , Meiling Liu , Shouzhuo Yao","doi":"10.1016/j.snb.2025.137709","DOIUrl":"10.1016/j.snb.2025.137709","url":null,"abstract":"<div><div>The emergence of various nanozymes has revolutionized approaches to detecting total antioxidant capacity (TAC) in food and biological samples; however, the precise quantification of specific antioxidant species such as ascorbic acid (AA) and glutathione (GSH) continue to present significant challenges. Inspired by the functional characteristics of oxidoreductases, we have developed Cu-CeO₂ nanoparticles adorned PCN-224, which exhibit multiple mimetic behaviors, including oxidase (OXD), ascorbate oxidase (AAO), and glutathione peroxidase (GPx)-like activities. This innovative PCN-224@Cu-CeO<sub>2</sub> is designed for the quantitative evaluation of TAC in food, pharmaceuticals, and biological samples. Simultaneously, it enables the accurate determination of AA and GSH levels with favorable selectivity. The integration of nanozymes onto metal-organic frameworks significantly enhances both stability and catalytic efficiency. Furthermore, utilizing the multi-mimetics activity of the same materials simplifies the biosensing processes for TAC and individual antioxidants in tablets, beverages, fruits, and cells, thereby considerably diminishing experimental intricacy. Our findings not only advance the development and applications of novel nanozymes with exceptional multi-mimetic properties but also tackle selectivity challenges associated with colorimetric detection platforms that rely on oxidase and peroxidase activities.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137709"},"PeriodicalIF":8.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid room-temperature NO2 detection based on Bi2S3/polyoxometalate heterostructures: the synergy of increased electron transportation and heterojunction effect

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-02 DOI: 10.1016/j.snb.2025.137742

Ping Li , Ying Yang , Feng Li , Wenyuan Pei , Dan Li , Hui Yu , Xiangting Dong , Tianqi Wang

With the significant increase in global awareness of environmental protection, green non-toxic gas sensors have become an important tool to promote sustainable development. In this work, a gas sensor based on Bi₂S₃ green non-toxic semiconductor material was successfully prepared. By introducing polyoxometalate (POMs) electron acceptor into Bi₂S₃ sensing material, its detection ability for NO₂ gas was significantly improved. At room temperature (25°C), the Bi₂S₃/1%PW₁₂ sensor has a response value of 41.88 to 100 ppm NO₂, which is 4.36 times the response value of the Bi₂S₃ sensor (9.61), highlighting its excellent detection performance. In addition, we thoroughly evaluated the selectivity, repeatability and other key gas sensing parameters of the sensor, further confirming its high-potential in practical applications. Through analysis of the mechanism underlying the performance enhancement, it is found that the appropriate addition of PW₁₂ as an electron acceptor can effectively inhibit the electron-hole recombination, thus significantly improving the performance of the sensor. This important discovery opens up a new way and method for the performance optimization of gas sensors, and is expected to inject new vitality into the future development of gas sensor technology.

{"title":"Rapid room-temperature NO2 detection based on Bi2S3/polyoxometalate heterostructures: the synergy of increased electron transportation and heterojunction effect","authors":"Ping Li , Ying Yang , Feng Li , Wenyuan Pei , Dan Li , Hui Yu , Xiangting Dong , Tianqi Wang","doi":"10.1016/j.snb.2025.137742","DOIUrl":"10.1016/j.snb.2025.137742","url":null,"abstract":"<div><div>With the significant increase in global awareness of environmental protection, green non-toxic gas sensors have become an important tool to promote sustainable development. In this work, a gas sensor based on Bi<sub>2</sub>S<sub>3</sub> green non-toxic semiconductor material was successfully prepared. By introducing polyoxometalate (POMs) electron acceptor into Bi<sub>2</sub>S<sub>3</sub> sensing material, its detection ability for NO<sub>2</sub> gas was significantly improved. At room temperature (25°C), the Bi<sub>2</sub>S<sub>3</sub>/1%PW<sub>12</sub> sensor has a response value of 41.88 to 100 ppm NO<sub>2</sub>, which is 4.36 times the response value of the Bi<sub>2</sub>S<sub>3</sub> sensor (9.61), highlighting its excellent detection performance. In addition, we thoroughly evaluated the selectivity, repeatability and other key gas sensing parameters of the sensor, further confirming its high-potential in practical applications. Through analysis of the mechanism underlying the performance enhancement, it is found that the appropriate addition of PW<sub>12</sub> as an electron acceptor can effectively inhibit the electron-hole recombination, thus significantly improving the performance of the sensor. This important discovery opens up a new way and method for the performance optimization of gas sensors, and is expected to inject new vitality into the future development of gas sensor technology.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137742"},"PeriodicalIF":8.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A high-performance light-induced thermoelastic spectroscopy sensor based on a high-Q value quartz tuning fork load

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-01 DOI: 10.1016/j.snb.2025.137713

Hanxu Ma , Xiaorong Sun , Shunda Qiao , Ying He , Chu Zhang , Yufei Ma

This paper reports for the first time a high-performance light-induced thermoelastic spectroscopy (LITES) sensor based on a high-quality factor (Q) quartz tuning fork (QTF) as the load. The high-Q QTF, sealed in a vacuum and featuring a Q factor of about 50000, is connected in series with a commercially available standard QTF to enable piezoelectric signal filtering, thereby increasing the overall Q-factor. Methane (CH₄), a highly flammable and explosive gas, is chosen as the target for this study. Compared to the bare QTF mode, the series QTF mode increased the Q value of the QTF detector by 2.11 times and the signal-to-noise ratio (SNR) of the CH₄-LITES sensor by 1.73 times. Under varying CH₄ concentrations, the series QTF mode-based CH₄-LITES sensor demonstrated an excellent linear response, with a calculated minimum detection limit (MDL) of 0.96 ppm. According to Allan deviation analysis, the MDL of the CH₄-LITES sensor was improved to 0.16 ppm when the average time of the system was 100 s. Additionally, to assess the frequency selectivity of the series QTF mode, external acoustic waves with a center frequency of 32.768 kHz were used for interference testing. The SNR of the bare QTF mode decreased by a factor of 108.92, while the SNR of the series QTF mode only decreased by a factor of 26.88. These results show that the series QTF mode provides 4 times greater anti-noise capacity, significantly enhancing the frequency selectivity of the LITES sensor.

{"title":"A high-performance light-induced thermoelastic spectroscopy sensor based on a high-Q value quartz tuning fork load","authors":"Hanxu Ma , Xiaorong Sun , Shunda Qiao , Ying He , Chu Zhang , Yufei Ma","doi":"10.1016/j.snb.2025.137713","DOIUrl":"10.1016/j.snb.2025.137713","url":null,"abstract":"<div><div>This paper reports for the first time a high-performance light-induced thermoelastic spectroscopy (LITES) sensor based on a high-quality factor (<em>Q</em>) quartz tuning fork (QTF) as the load. The high-Q QTF, sealed in a vacuum and featuring a <em>Q</em> factor of about 50000, is connected in series with a commercially available standard QTF to enable piezoelectric signal filtering, thereby increasing the overall Q-factor. Methane (CH<sub>4</sub>), a highly flammable and explosive gas, is chosen as the target for this study. Compared to the bare QTF mode, the series QTF mode increased the <em>Q</em> value of the QTF detector by 2.11 times and the signal-to-noise ratio (SNR) of the CH<sub>4</sub>-LITES sensor by 1.73 times. Under varying CH<sub>4</sub> concentrations, the series QTF mode-based CH<sub>4</sub>-LITES sensor demonstrated an excellent linear response, with a calculated minimum detection limit (MDL) of 0.96 ppm. According to Allan deviation analysis, the MDL of the CH<sub>4</sub>-LITES sensor was improved to 0.16 ppm when the average time of the system was 100s. Additionally, to assess the frequency selectivity of the series QTF mode, external acoustic waves with a center frequency of 32.768kHz were used for interference testing. The SNR of the bare QTF mode decreased by a factor of 108.92, while the SNR of the series QTF mode only decreased by a factor of 26.88. These results show that the series QTF mode provides 4 times greater anti-noise capacity, significantly enhancing the frequency selectivity of the LITES sensor.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137713"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent respiratory rate detection using disposable paper-based humidity sensor and precise peak-seeking algorithm 利用一次性纸质湿度传感器和精确的峰值搜索算法进行智能呼吸频率检测

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-01 DOI: 10.1016/j.snb.2025.137738

Chong Tan , Yu Cao , Nan Xie , Mingxiang Zhang , Lili Liu , Haichao Yu , Changhong Wang , Yaowen Jiang , Yuanming Wu , Zhen Yuan , Zaihua Duan , Yadong Jiang , Huiling Tai

The traditional respiratory rate detection techniques, such as clinic monitor and ventilator, are often limited to specific application scenarios due to their complexity and high cost. In this work, we propose a disposable and cost-effective paper-based (PB) LiCl humidity sensor. The results show that the PB LiCl humidity sensor can detect a relative humidity (RH) range of 28.8–91.5 %, with alternating current impedance of 562.9 and direct current resistance response of 10,928.8 at 91.5 % RH (25°C). Notably, the incorporation of LiCl reduces the resistance of the paper material, which makes it easier for the circuit to obtain the resistance value. To achieve automatic recognition of respiratory rate, we propose a precise peak-seeking algorithm based on extreme value detection, addressing the baseline drift issue encountered in actual respiratory detection by humidity sensor. The corresponding circuit system is designed, which can accurately capture and analyze humidity changes caused by respiration, generate real-time respiratory response curves, and calculate respiratory rates, achieving intelligent respiratory rate detection. This work provides a useful reference for developing portable and low-cost respiratory detection equipment based on the disposable PB LiCl humidity sensor.

{"title":"Intelligent respiratory rate detection using disposable paper-based humidity sensor and precise peak-seeking algorithm","authors":"Chong Tan , Yu Cao , Nan Xie , Mingxiang Zhang , Lili Liu , Haichao Yu , Changhong Wang , Yaowen Jiang , Yuanming Wu , Zhen Yuan , Zaihua Duan , Yadong Jiang , Huiling Tai","doi":"10.1016/j.snb.2025.137738","DOIUrl":"10.1016/j.snb.2025.137738","url":null,"abstract":"<div><div>The traditional respiratory rate detection techniques, such as clinic monitor and ventilator, are often limited to specific application scenarios due to their complexity and high cost. In this work, we propose a disposable and cost-effective paper-based (PB) LiCl humidity sensor. The results show that the PB LiCl humidity sensor can detect a relative humidity (RH) range of 28.8–91.5 %, with alternating current impedance of 562.9 and direct current resistance response of 10,928.8 at 91.5 % RH (25°C). Notably, the incorporation of LiCl reduces the resistance of the paper material, which makes it easier for the circuit to obtain the resistance value. To achieve automatic recognition of respiratory rate, we propose a precise peak-seeking algorithm based on extreme value detection, addressing the baseline drift issue encountered in actual respiratory detection by humidity sensor. The corresponding circuit system is designed, which can accurately capture and analyze humidity changes caused by respiration, generate real-time respiratory response curves, and calculate respiratory rates, achieving intelligent respiratory rate detection. This work provides a useful reference for developing portable and low-cost respiratory detection equipment based on the disposable PB LiCl humidity sensor.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"436 ","pages":"Article 137738"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A near-infrared AIE-active Ir(III) complex with a super-large stokes shift and efficient singlet oxygen generation

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-01 DOI: 10.1016/j.snb.2025.137741

Lei Wang , Haoke Zhang , Yuge Guan , Chun Liu

Iridium complexes have shown broad applicability across various fields, particularly in bioimaging and photodynamic therapy owing to their exceptional photophysical properties. However, their effectiveness in biological applications is often constrained by aggregation-caused quenching (ACQ), which reduces luminescence efficiency, impairs precise targeting, and lowers singlet oxygen generation. Herein, this study report the design and synthesis of a novel trifluoromethylated cationic cyclometalated Ir(III) complex incorporating diphenylamino (DPA) and trifluoromethyl groups, which exhibits desirable Aggregation-Induced Emission (AIE) characteristics, an ultra-large Stokes shift, and near-infrared (NIR) emission. Comprehensive structural and photophysical analyses, including single-crystal X-ray diffraction and transmission electron microscopy, reveal that these Ir(III) complexes exhibit strong aggregation behavior, significant π-π and C-H···F interactions, and remarkable oxygen sensitivity in ethyl cellulose (EC) films (

K_{SV}^{app}

= 0.05586 Torr^-¹). Notably, the DPA-modified complex Ir3 enhances singlet oxygen generation within intracellular environments, exhibiting distinct phototoxicity and minimal dark toxicity against Henrietta Lacks (HeLa) cells. This work advances the design strategy for AIE-active Ir(III) complexes for photodynamic therapy (PDT) and oxygen sensing, providing insights into developing functional materials with enhanced NIR emission, large Stokes shifts, and selective bioimaging capabilities. These findings lay a promising foundation for further application of Ir(III) complexes in cancer phototherapy and other biomedical fields.

铱复合物因其卓越的光物理特性，已在各个领域显示出广泛的适用性，尤其是在生物成像和光动力疗法方面。然而，它们在生物应用中的有效性往往受到聚集引起的淬灭（ACQ）的限制，ACQ 会降低发光效率，影响精确靶向，并降低单线态氧的生成。在此，本研究报告了一种新型三氟甲基阳离子环甲基化 Ir(III) 复合物的设计与合成，该复合物含有二苯基氨基（DPA）和三氟甲基，具有理想的聚集诱导发射（AIE）特性、超大斯托克斯位移和近红外（NIR）发射。包括单晶 X 射线衍射和透射电子显微镜在内的全面结构和光物理分析表明，这些铱（III）配合物具有很强的聚集行为、显著的 π-π 和 C-H-F 相互作用，并且在乙基纤维素（EC）薄膜中具有显著的氧敏感性（KSVapp= 0.05586 Torr-¹）。值得注意的是，DPA修饰的复合物Ir3能增强细胞内环境中单线态氧的生成，对Henrietta Lacks（HeLa）细胞具有明显的光毒性和最小的暗毒性。这项工作推进了用于光动力疗法（PDT）和氧传感的 AIE 活性 Ir(III)复合物的设计策略，为开发具有增强的近红外发射、大斯托克斯偏移和选择性生物成像能力的功能材料提供了见解。这些发现为 Ir(III)配合物在癌症光疗和其他生物医学领域的进一步应用奠定了良好的基础。

{"title":"A near-infrared AIE-active Ir(III) complex with a super-large stokes shift and efficient singlet oxygen generation","authors":"Lei Wang , Haoke Zhang , Yuge Guan , Chun Liu","doi":"10.1016/j.snb.2025.137741","DOIUrl":"10.1016/j.snb.2025.137741","url":null,"abstract":"<div><div>Iridium complexes have shown broad applicability across various fields, particularly in bioimaging and photodynamic therapy owing to their exceptional photophysical properties. However, their effectiveness in biological applications is often constrained by aggregation-caused quenching (ACQ), which reduces luminescence efficiency, impairs precise targeting, and lowers singlet oxygen generation. Herein, this study report the design and synthesis of a novel trifluoromethylated cationic cyclometalated Ir(III) complex incorporating diphenylamino (DPA) and trifluoromethyl groups, which exhibits desirable Aggregation-Induced Emission (AIE) characteristics, an ultra-large Stokes shift, and near-infrared (NIR) emission. Comprehensive structural and photophysical analyses, including single-crystal X-ray diffraction and transmission electron microscopy, reveal that these Ir(III) complexes exhibit strong aggregation behavior, significant π-π and C-H···F interactions, and remarkable oxygen sensitivity in ethyl cellulose (EC) films (<span><math><msubsup><mrow><mi>K</mi></mrow><mrow><mi>SV</mi></mrow><mrow><mi>app</mi></mrow></msubsup></math></span>= 0.05586 Torr<sup>-</sup>¹). Notably, the DPA-modified complex <strong>Ir3</strong> enhances singlet oxygen generation within intracellular environments, exhibiting distinct phototoxicity and minimal dark toxicity against Henrietta Lacks (HeLa) cells. This work advances the design strategy for AIE-active Ir(III) complexes for photodynamic therapy (PDT) and oxygen sensing, providing insights into developing functional materials with enhanced NIR emission, large Stokes shifts, and selective bioimaging capabilities. These findings lay a promising foundation for further application of Ir(III) complexes in cancer phototherapy and other biomedical fields.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137741"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-site detection of extracellular antibiotic resistance genes by magnetic solid phase extraction-light driven amplification-lateral flow assay

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-01 DOI: 10.1016/j.snb.2025.137707

Yi-Nan Yang , Zhao-Hui Wang , Yue Huang , Li-Xia Yan , Xiao-Dong Huang , Wen-Long Wang , Wen-Feng Zhao , Yong-Wei Feng , Yi Zhang

Antibiotic resistance genes (ARGs), especially extracellular ARGs (eARGs), are recognized as emerging pollutants that pose significant threats to public health and the environment, characterized by their increased transmission risk across bacterial genera and the difficulty in monitoring them. Herein, a comprehensive method for the efficient detection of eARGs was developed, integrating magnetic solid phase extraction (MSPE), light-driven (LD) recombinase polymerase amplification (RPA), and lateral flow assay (LFA). Initially, Fe₃O₄@polydopamine (Fe₃O₄@PDA) was utilized as the adsorbent in MSPE to extract eARGs from samples. The extracellular sulfonamide resistance gene sul1 was chosen as a model analyte for this study. Subsequently, the efficiency of nucleic acid amplification was significantly enhanced by 2.2 times compared to traditional water-bathed RPA, through the implementation of LD-RPA. This technique employed a portable laser flashlight as the light source and Fe₃O₄@PDA as the photosensitive medium, facilitating rapid and efficient amplification of the target gene. Following amplification, the specifically designed LFA was utilized for the detection of the amplicons. The resulting assay demonstrated a wide linear range of 10 copies/µL to 1.0 × 10⁵ copies/µL in the eluent of MSPE (R² = 0.9939), with a remarkable detection limit of 10 copies/µL eluent, corresponding to 3.3 × 10⁻² copies/µL in water samples. The entire analytical procedure costs only 35 min. To validate the method, environmental water samples were tested, and the results obtained were found to be in good agreement with those from real-time quantitative polymerase chain reaction, further substantiating the accuracy and efficacy of the integrated MSPE–LD-RPA–LFA approach.

{"title":"On-site detection of extracellular antibiotic resistance genes by magnetic solid phase extraction-light driven amplification-lateral flow assay","authors":"Yi-Nan Yang , Zhao-Hui Wang , Yue Huang , Li-Xia Yan , Xiao-Dong Huang , Wen-Long Wang , Wen-Feng Zhao , Yong-Wei Feng , Yi Zhang","doi":"10.1016/j.snb.2025.137707","DOIUrl":"10.1016/j.snb.2025.137707","url":null,"abstract":"<div><div>Antibiotic resistance genes (ARGs), especially extracellular ARGs (eARGs), are recognized as emerging pollutants that pose significant threats to public health and the environment, characterized by their increased transmission risk across bacterial genera and the difficulty in monitoring them. Herein, a comprehensive method for the efficient detection of eARGs was developed, integrating magnetic solid phase extraction (MSPE), light-driven (LD) recombinase polymerase amplification (RPA), and lateral flow assay (LFA). Initially, Fe<sub>3</sub>O<sub>4</sub>@polydopamine (Fe<sub>3</sub>O<sub>4</sub>@PDA) was utilized as the adsorbent in MSPE to extract eARGs from samples. The extracellular sulfonamide resistance gene <em>sul1</em> was chosen as a model analyte for this study. Subsequently, the efficiency of nucleic acid amplification was significantly enhanced by 2.2 times compared to traditional water-bathed RPA, through the implementation of LD-RPA. This technique employed a portable laser flashlight as the light source and Fe<sub>3</sub>O<sub>4</sub>@PDA as the photosensitive medium, facilitating rapid and efficient amplification of the target gene. Following amplification, the specifically designed LFA was utilized for the detection of the amplicons. The resulting assay demonstrated a wide linear range of 10 copies/µL to 1.0 × 10<sup>5</sup> copies/µL in the eluent of MSPE (R<sup>2</sup> = 0.9939), with a remarkable detection limit of 10 copies/µL eluent, corresponding to 3.3 × 10<sup>−2</sup> copies/µL in water samples. The entire analytical procedure costs only 35 min. To validate the method, environmental water samples were tested, and the results obtained were found to be in good agreement with those from real-time quantitative polymerase chain reaction, further substantiating the accuracy and efficacy of the integrated MSPE–LD-RPA–LFA approach.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137707"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In operando spatiotemporal analysis of ion concentration profile using ion-selective membrane probes in electrokinetic systems

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-04-01 DOI: 10.1016/j.snb.2025.137737

Joowon Seo , Junsuk Kim , Beomjoon Kim , Ali Mani , Sungjae Ha , Sung Jae Kim

Accurate in operando measurement of electric potential in electrokinetic systems is critical yet challenging due to complications arising from electrochemical reactions and electrical double layer capacitance at the metal electrode-electrolyte interface. These challenges are further compounded under in operando conditions requiring simultaneous voltage application and measurement, where conventional probes often induce leakage currents and distort measurements. To overcome these limitations, we developed an ion-selective membrane (ISM) probe with high input impedance, capable of transferring charge as a form of ion, thereby suppressing redox reactions and eliminating leakage currents. Integrated into a microfluidic platform, the ISM probe demonstrated robust performance across a wide resistance range, with reliable operation even in giga-ohm environments, a suitable cutoff frequency for tracking dynamic potentials, and significantly reduced noise and measurement offset compared to traditional metal-based probes. Leveraging these advantages, we employed the ISM probe to perform in operando dynamic analysis of ion concentration, particularly focusing on electrokinetic phenomena such as ion concentration polarization (ICP). The probe enabled precise spatial and temporal measurement of concentration gradients formed by ICP, offering new insights into ion distribution dynamics; (1) issues in visualizing ion concentrations using fluorescence and (2) the second plateau of ion concentration near nanoporous membranes. This work establishes the ISM probe as a versatile tool for advancing the understanding of ion profiles in complex electrokinetic systems, addressing key challenges in both fundamental research and practical applications.

{"title":"In operando spatiotemporal analysis of ion concentration profile using ion-selective membrane probes in electrokinetic systems","authors":"Joowon Seo , Junsuk Kim , Beomjoon Kim , Ali Mani , Sungjae Ha , Sung Jae Kim","doi":"10.1016/j.snb.2025.137737","DOIUrl":"10.1016/j.snb.2025.137737","url":null,"abstract":"<div><div>Accurate <em>in operando</em> measurement of electric potential in electrokinetic systems is critical yet challenging due to complications arising from electrochemical reactions and electrical double layer capacitance at the metal electrode-electrolyte interface. These challenges are further compounded under <em>in operando</em> conditions requiring simultaneous voltage application and measurement, where conventional probes often induce leakage currents and distort measurements. To overcome these limitations, we developed an ion-selective membrane (ISM) probe with high input impedance, capable of transferring charge as a form of ion, thereby suppressing redox reactions and eliminating leakage currents. Integrated into a microfluidic platform, the ISM probe demonstrated robust performance across a wide resistance range, with reliable operation even in giga-ohm environments, a suitable cutoff frequency for tracking dynamic potentials, and significantly reduced noise and measurement offset compared to traditional metal-based probes. Leveraging these advantages, we employed the ISM probe to perform <em>in operando</em> dynamic analysis of ion concentration, particularly focusing on electrokinetic phenomena such as ion concentration polarization (ICP). The probe enabled precise spatial and temporal measurement of concentration gradients formed by ICP, offering new insights into ion distribution dynamics; (1) issues in visualizing ion concentrations using fluorescence and (2) the second plateau of ion concentration near nanoporous membranes. This work establishes the ISM probe as a versatile tool for advancing the understanding of ion profiles in complex electrokinetic systems, addressing key challenges in both fundamental research and practical applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"437 ","pages":"Article 137737"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0