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Electrochemical nanopore sensors based on versatile zeolites achieve the discrimination and selective rapid detection of bisphenol structural analogues 基于多用途沸石的电化学纳米孔传感器实现了双酚类结构类似物的判别和选择性快速检测
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-06 DOI: 10.1016/j.snb.2026.139619
Lin Wang , Xinbao Zhang , Yuxi Jiao , Mengqiong Zhang , Xinyan Liu , Xiujie Li , Xiangxue Zhu , Shuang Han , Haijun Zhang , Jiping Chen , Lidong Wu , Xianbo Lu
Discriminating and selective detection of structurally similar multi-analytes remains a major challenge in chemical sensing due to severe cross-response interference from shared molecular skeletons and functional groups. To address this, we report a novel zeolite-based nanopore sensing strategy that leverages the uniform nanopore channels and tunable adsorption properties of zeolites for achieving high selectivity in multi-analyte systems. Using bisphenol AF (BPAF) and bisphenol S (BPS)—two electrochemically overlapping phenolic pollutants with extreme similar structure—as model targets, we engineered and studied four zeolites: hydrophilic Hβ, surface-hydrophobic OS-Hβ (prepared by organosilane modification of Hβ), and two hydrophilic Y-type zeolites with contrasting Si/Al ratios (HY‑686 and NaY‑5). Notably, these materials exhibited distinct nanopore adsorption preferences: Hβ selectively adsorbed BPS, whereas OS-Hβ favored BPAF only; HY‑686 adsorbed both bisphenols, while NaY‑5 showed negligible uptake. Mechanistic studies revealed that for Beta-type zeolites with similar nanopore sizes, surface hydrophilicity/hydrophobicity governs selectivity, whereas for hydrophilic Y-type zeolites, nanopore size plays the decisive role. Building on this principle, we developed an innovative electrochemical nanopore sensing platform that integrates selective molecular absorption, in situ electrocatalysis, and interference-free detection, enabling accurate discrimination and quantification of BPAF and BPS in complex samples. This work not only resolves a persistent sensing challenge for structurally analogous analytes but also establishes a generalizable molecular‑sieving nanopore sensing principle for selective adsorption, electrocatalysis, and sensing applications.
由于来自共享分子骨架和官能团的严重交叉响应干扰,对结构相似的多分析物进行判别和选择性检测仍然是化学传感的主要挑战。为了解决这个问题,我们报告了一种新的基于沸石的纳米孔传感策略,该策略利用沸石的均匀纳米孔通道和可调吸附特性,在多分析物系统中实现高选择性。以双酚AF (BPAF)和双酚S (BPS) -两种结构极其相似的电化学重叠的酚类污染物-为模型靶点,我们设计并研究了四种沸石:亲水性Hβ,表面疏水性OS-Hβ(通过Hβ的有机硅烷改性制备),以及两种具有不同Si/Al比的亲水性y型沸石(HY - 686和NaY - 5)。值得注意的是,这些材料表现出明显的纳米孔吸附偏好:Hβ选择性地吸附BPS,而OS-Hβ只吸附BPAF;HY - 686吸附了两种双酚,而NaY - 5的吸收率可以忽略不计。机理研究表明,对于具有相似纳米孔尺寸的β型沸石,表面亲水性/疏水性决定选择性,而对于亲水性y型沸石,纳米孔尺寸起决定性作用。基于这一原理,我们开发了一种创新的电化学纳米孔传感平台,该平台集成了选择性分子吸收、原位电催化和无干扰检测,能够准确区分和定量复杂样品中的BPAF和BPS。这项工作不仅解决了结构类似分析物的持续传感挑战,而且还为选择性吸附,电催化和传感应用建立了可推广的分子筛纳米孔传感原理。
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引用次数: 0
Photoacoustic multi-gas sensor using mode division multiplexing 采用模分复用的光声多气体传感器
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-01 DOI: 10.1016/j.snb.2026.139583
Mu Liang , Mingqi Jiao , Qing Yang , Mingyang Feng , Pengbo Chen , Yang Gao , Ya Gao , Yingying Qiao , Lei Li , Chongxin Shan
The multi-gas detection technology based on photoacoustic spectroscopy (PAS) has significant application value in fields such as power equipment, environmental protection, and medical diagnosis. It mainly relies on time-division multiplexing (TDM) and frequency-division multiplexing (FDM) technologies, but both have inherent technical limitations. TDM requires sequentially performing gas detection, resulting in a detection cycle that grows proportionally with the number of gas species, thus rendering it unsuitable for rapid multi-gas detection scenarios; FDM faces the contradictory between multi-frequency requirements and the uniqueness of the optimal resonant frequency, along with the drawback that deploying multiple lock-in amplifiers increases equipment costs and elevates system integration complexity. Therefore, we propose a mode-division multiplexing (MDM) method, which enables simultaneous and same-frequency measurements of multiple gases. By assigning differentiated scanning periods to different gases, the method encodes gas-specific width modes into mixed signals and achieves separation through a custom-designed signal separation framework. The system demonstrated linear fitting (R²) of 0.998 and 0.997 for CO and H2S detection, with minimum detection limits reaching 75 ppb and 139 ppb. This method is applicable to all absorption spectroscopy-based multi-gas detection techniques employing wavelength modulation spectroscopy (WMS), offering a novel approach for multi-gas detection schemes.
基于光声光谱(PAS)的多气体检测技术在电力设备、环境保护、医疗诊断等领域具有重要的应用价值。它主要依靠时分复用(TDM)和频分复用(FDM)技术,但两者都有固有的技术局限性。TDM需要依次进行气体检测,导致检测周期与气体种类数量成比例增长,因此不适合快速的多气体检测场景;FDM面临着多频要求与最佳谐振频率唯一性之间的矛盾,以及部署多个锁相放大器增加设备成本和提高系统集成复杂性的缺点。因此,我们提出了一种模分多路复用(MDM)方法,它可以同时和同频率测量多种气体。该方法通过对不同气体分配不同的扫描周期,将特定气体的宽度模式编码为混合信号,并通过定制设计的信号分离框架实现分离。系统对CO和H2S的线性拟合(R²)分别为0.998和0.997,最低检出限分别为75 ppb和139 ppb。该方法适用于所有波长调制光谱(WMS)吸收光谱的多气体检测技术,为多气体检测方案提供了一种新的途径。
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引用次数: 0
Electrochemical aptasensor for trimethoprim detection based on Pd@Ir bimetallic nanoparticles coupled with hybrid chain reaction 基于Pd@Ir双金属纳米颗粒耦合杂化链式反应的甲氧苄氨嘧啶电化学感应传感器
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-01-30 DOI: 10.1016/j.snb.2026.139575
Man Ding , Hong Xu , Mengxia Duan , Meihua Dong , Kuaile Wu , Shijia Wu , Changqing Zhu , Nuo Duan
Trimethoprim (TMP), a widely used veterinary antibacterial, accumulates in animal-derived foods and poses health risks like bacterial resistance and bone marrow hematopoietic suppression. Herein, an ultrasensitive electrochemical aptasensor was developed by integrating molecular docking-optimized TMP-specific aptamers, Pd@Ir bimetallic nanoparticles (Pd@Ir NPs) for signal enhancement, and hybrid chain reaction (HCR) for signal amplification. First, a high-affinity TMP-specific aptamer TMP-1 was screened via Capture-SELEX. Through molecular docking to identify core binding sites and truncate redundant sequences, TMP-1 was optimized into the 56 nt TMP-1C with enhanced affinity (The Kd was determined to be 41.6 nM by SGI assays). Pd@Ir NPs with excellent conductivity and electrocatalytic activity were coupled to hairpin H2 to form Pd@Ir NPs@H2 probes. For sensor construction, thiol-modified cDNA-TMP-1C duplexes were immobilized on gold electrodes, the binding between TMP and aptamer induced the duplex de-hybridization, and the exposed cDNA opened H1 and triggered HCR, thereby achieving Pd@Ir NPs enrichment and signal amplification. This method exhibits an ultra-low limit of detection (LOD) of 0.02 ng/mL. The spiked recovery experiments on pork samples show that the recovery rate of TMP ranges from 92.00 % to 93.99 % with a relative standard deviation (RSD) of 3.34 %–3.89 %, confirming its accuracy in practical samples. This sensor provides an efficient, high-performance tool for TMP residue detection in food safety monitoring.
甲氧苄啶(TMP)是一种广泛使用的兽用抗菌药物,在动物源性食品中积累,并造成细菌耐药性和骨髓造血抑制等健康风险。本文通过整合分子对接优化的tmp特异性适配体、Pd@Ir双金属纳米粒子(Pd@Ir NPs)用于信号增强和杂化链反应(HCR)用于信号放大,开发了一种超灵敏的电化学适配体传感器。首先,通过Capture-SELEX筛选高亲和力的tmp特异性适配体TMP-1。通过分子对接鉴定核心结合位点,截断冗余序列,将TMP-1优化为56 nt的具有增强亲和力的TMP-1C(经SGI测定Kd为41.6 nM)。将具有优异导电性和电催化活性的Pd@Ir NPs与发夹H2偶联形成Pd@Ir NPs@H2探针。在传感器构建中,将巯基修饰的cDNA-TMP- 1c双链固定在金电极上,TMP与适体结合诱导双链去杂交,暴露的cDNA打开H1并触发HCR,从而实现Pd@Ir NPs富集和信号扩增。该方法的超低检出限为0.02 ng/mL。在猪肉样品中加标回收率为92.00 % ~ 93.99 %,相对标准偏差(RSD)为3.34 % ~ 3.89 %,验证了该方法在实际样品中的准确性。该传感器为食品安全监测中TMP残留检测提供了一种高效、高性能的工具。
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引用次数: 0
A detection method for industrial methanol and ethanol two-component gas leakage based on transient response sequence 基于瞬态响应序列的工业甲醇和乙醇双组分气体泄漏检测方法
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-01-28 DOI: 10.1016/j.snb.2026.139563
Hanyang Ji , Renze Zhang , Lu Kong , Zhenyu Yuan , Fanli Meng
This study addresses the challenge of rapid methanol and ethanol leakage monitoring during coke oven gas conversion by proposing a transient response sequence method based on a semiconductor gas sensor for fast qualitative and quantitative analysis of binary mixtures. Using programmed temperature ramping (0–6 V, 50 s, 0.12 V/s), distinct characteristic peaks were identified at 4.70 V for methanol and 4.38 V for ethanol, enabling reliable gas discrimination. First-order differential processing enhanced methanol detection specificity in mixtures. A two-dimensional concentration estimation model based on dual peak amplitudes was established using Rational2D fitting, achieving average errors of 5.74 % for methanol and 1.64 % for ethanol. The method exhibits high speed and accuracy, showing strong potential for rapid multi-component gas analysis in industrial settings.
本文提出了一种基于半导体气体传感器的瞬态响应序列方法,用于二元混合物的快速定性和定量分析,解决了焦炉煤气转化过程中甲醇和乙醇泄漏的快速监测挑战。通过编程升温(0-6 V, 50 s, 0.12 V/s),甲醇和乙醇分别在4.70 V和4.38 V处识别出了不同的特征峰,从而实现了可靠的气体鉴别。一阶微分处理提高了混合物中甲醇检测的特异性。利用Rational2D拟合建立了基于双峰振幅的二维浓度估计模型,甲醇和乙醇的平均误差分别为5.74 %和1.64 %。该方法具有高速度和准确性,在工业环境中显示出强大的快速多组分气体分析潜力。
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引用次数: 0
MoS2/CdS quantum dot heterojunction-based photoelectrochemical sensors for detecting persistent organic pollutants PCB28 in atmospheric precipitation 基于MoS2/CdS量子点异质结的大气降水中持久性有机污染物PCB28检测传感器
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.snb.2026.139593
Yeqing Liu , Hailin Zheng , Heng Liu , Chengyi Xiong , Yao Xiao , Miao-Miao Chen , Shengfu Wang , Xiuhua Zhang
Polychlorinated biphenyls (PCBs) have drawn widespread international attention as persistent carcinogens posing significant environmental hazards. There has been an urgent need to develop rapid, sensitive, and portable methods to support environmental monitoring and pollution control. This work developed a photoelectrochemical (PEC) sensor based on molybdenum disulfide (MoS2) nanosheets/CdS quantum dots (QDs) heterojunction for sensitive PCB28 detection in atmospheric precipitation. MoS2 nanosheets served as both anchored platforms and protective layers to stabilize CdS QDs and prevented them from photocorrosion. The clean interface of 2D/0D MoS2/CdS QDs heterojunctions could help to hinder photogenerated carrier recombination effectively, which then enabled electron-hole pairs to be significantly separated and thereby comprehensively improved sensor performances. The introduction of molecularly imprinted polymers (MIPs) with cavities specifically recognizing PCB28 enabled highly selective detection of the target compound. The sensor demonstrated good performance with a detection limit of 4.04 fg/mL. In practical atmospheric precipitation detection, results from this method were in good agreement with gas chromatography measurements. Furthermore, the sensor with the advantages of portability, simple pretreatment, and low cost, provided a novel strategy for reliable detection of trace pollutants in complex ambience. It also demonstrated that multidimension synergistic effects offered by mixed-dimensional heterojunctions could further enhance optoelectronic sensor performances for environmental monitoring.
多氯联苯作为具有重大环境危害的持久性致癌物已引起国际社会的广泛关注。迫切需要开发快速、灵敏、便携的方法来支持环境监测和污染控制。本文研制了一种基于二硫化钼(MoS2)纳米片/CdS量子点(QDs)异质结的光电化学(PEC)传感器,用于大气降水中PCB28的灵敏检测。MoS2纳米片作为锚定平台和保护层来稳定CdS量子点并防止其光腐蚀。2D/0D MoS2/CdS量子点异质结的干净界面可以有效地阻止光生载流子重组,从而使电子-空穴对显著分离,从而全面提高传感器性能。引入具有特异性识别PCB28的空腔的分子印迹聚合物(MIPs)能够高度选择性地检测目标化合物。该传感器性能良好,检出限为4.04 fg/mL。在实际大气降水检测中,该方法与气相色谱法测量结果吻合较好。此外,该传感器具有便携、预处理简单、成本低等优点,为复杂环境中痕量污染物的可靠检测提供了一种新策略。研究还表明,混合异质结提供的多维协同效应可以进一步提高光电传感器在环境监测中的性能。
{"title":"MoS2/CdS quantum dot heterojunction-based photoelectrochemical sensors for detecting persistent organic pollutants PCB28 in atmospheric precipitation","authors":"Yeqing Liu ,&nbsp;Hailin Zheng ,&nbsp;Heng Liu ,&nbsp;Chengyi Xiong ,&nbsp;Yao Xiao ,&nbsp;Miao-Miao Chen ,&nbsp;Shengfu Wang ,&nbsp;Xiuhua Zhang","doi":"10.1016/j.snb.2026.139593","DOIUrl":"10.1016/j.snb.2026.139593","url":null,"abstract":"<div><div>Polychlorinated biphenyls (PCBs) have drawn widespread international attention as persistent carcinogens posing significant environmental hazards. There has been an urgent need to develop rapid, sensitive, and portable methods to support environmental monitoring and pollution control. This work developed a photoelectrochemical (PEC) sensor based on molybdenum disulfide (MoS<sub>2</sub>) nanosheets/CdS quantum dots (QDs) heterojunction for sensitive PCB28 detection in atmospheric precipitation. MoS<sub>2</sub> nanosheets served as both anchored platforms and protective layers to stabilize CdS QDs and prevented them from photocorrosion. The clean interface of 2D/0D MoS<sub>2</sub>/CdS QDs heterojunctions could help to hinder photogenerated carrier recombination effectively, which then enabled electron-hole pairs to be significantly separated and thereby comprehensively improved sensor performances. The introduction of molecularly imprinted polymers (MIPs) with cavities specifically recognizing PCB28 enabled highly selective detection of the target compound. The sensor demonstrated good performance with a detection limit of 4.04 fg/mL. In practical atmospheric precipitation detection, results from this method were in good agreement with gas chromatography measurements. Furthermore, the sensor with the advantages of portability, simple pretreatment, and low cost, provided a novel strategy for reliable detection of trace pollutants in complex ambience. It also demonstrated that multidimension synergistic effects offered by mixed-dimensional heterojunctions could further enhance optoelectronic sensor performances for environmental monitoring.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"454 ","pages":"Article 139593"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A session-lasting biostable and biocompatible hydrogel microneedle patch for nanozyme-mediated on-site and smartphone-based quantification of skin H₂O₂ 一种持久的生物稳定和生物相容性的水凝胶微针贴片,用于纳米酶介导的现场和基于智能手机的皮肤H₂O₂定量
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-07 DOI: 10.1016/j.snb.2026.139621
Sihui Wang , Feng Liu , Meng Sun , Hongchun Gu , Lei Yang , Xun Feng , Yang Chen
Hydrogen peroxide (H₂O₂) in skin tissue serves as a critical biomarker for oxidative stress and physiological status, yet its precise in situ monitoring remains challenging due to the lack of non-invasive, real-time sensing platforms. Herein, we presented a smartphone-assisted biosensing system based on a nanozyme-integrated hydrogel microneedle patch for on-site and quantitative detection of cutaneous H₂O₂. The sensing platform incorporated a palladium-embedded metal-organic framework (Pd-PCN) with enhanced peroxidase-like activity, which was co-immobilized with a chromogenic substrate in a polymeric composite hydrogel microneedle array. This composite matrix maintained structural integrity and biocompatibility during short-term skin application while providing an aqueous microenvironment favorable for nanozyme-catalyzed reactions. Upon insertion into the skin, H₂O₂ from interstitial fluid would diffuse into the microneedle and trigger a colorimetric reaction. The resulting color intensity could be quantitatively captured via smartphone-based RGB analysis. The system demonstrated a wide linear detection range (5–100 µM), a low detection limit (1.53 µM), high reproducibility (RSD < 5 %), and negligible interference from common biological substances. Confocal imaging and mechanical testing further confirm the structural stability and skin-penetration capability of the microneedle under operational conditions. This work established a reliable, minimally invasive, and user-friendly platform for continuous monitoring of oxidative biomarkers in skin, paving the way for personalized dermatological care and point-of-care diagnostics.
皮肤组织中的过氧化氢(H₂O₂)是氧化应激和生理状态的重要生物标志物,但由于缺乏非侵入性实时传感平台,其精确的原位监测仍然具有挑战性。在此,我们提出了一种基于纳米酶集成水凝胶微针贴片的智能手机辅助生物传感系统,用于现场和定量检测皮肤H₂O₂。传感平台采用具有增强过氧化物酶样活性的钯嵌入金属有机框架(Pd-PCN),在聚合物复合水凝胶微针阵列中与显色底物共固定。这种复合基质在短期皮肤应用中保持结构完整性和生物相容性,同时提供有利于纳米酶催化反应的水微环境。在插入皮肤后,来自组织液的h2o会扩散到微针中并引发比色反应。由此产生的色彩强度可以通过基于智能手机的RGB分析来定量捕获。该系统线性检测范围宽(5~100µM),检出限低(1.53µM),重现性高(RSD < 5%),可忽略普通生物物质的干扰。共聚焦成像和力学测试进一步证实了微针在操作条件下的结构稳定性和穿皮能力。这项工作建立了一个可靠的、微创的、用户友好的平台,用于持续监测皮肤中的氧化生物标志物,为个性化皮肤病学护理和即时诊断铺平了道路。
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引用次数: 0
Corrigendum to “Defect-engineered WO3-X pollen-like architectures for highly sensitive and selective detection of Listeria biomarkers” [Sens. Actuators B Chem. 451 (2026) 139331] “用于高灵敏度和选择性检测李斯特菌生物标志物的缺陷工程WO3-X花粉样结构”的更正[Sens. Actuators B Chem. 451 (2026) 139331]
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI: 10.1016/j.snb.2026.139609
Chuanxuan Zhou , Jun Min , Linchuan Zuo , Fuchao Yang , Zhiguang Guo
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引用次数: 0
GenHome®: Development of a next-generation all-in-one molecular point-of-care testing platform with high sensitivity and accessibility GenHome®:开发具有高灵敏度和可及性的下一代一体化分子护理点检测平台
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-01 DOI: 10.1016/j.snb.2026.139590
Jiwoo Choi , Sungmin Kim , Qute Choi , Hyun Jin Kim , Hyun Kyu Yoon , In Hyuk Chung , Junho Maeng
SARS-CoV-2 (COVID-19) pandemic has highlighted the need for rapid and accurate molecular point-of-care testing (mPOCT). Here, we describe the development of GenHome®, a fully integrated, single-use cartridge platform that performs sample loading, direct nucleic-acid preparation, loop-mediated isothermal amplification (LAMP), and lateral-flow readout within a closed-system workflow, minimizing user intervention and providing results within 30 min. As the first cartridge of its type, we validated the GenHome® SARS-CoV-2 cartridge targeting the ORF1ab gene from SARS-CoV-2. Under optimized conditions (65 °C, 20 min), GenHome® achieved a limit of detection (LoD) of 194 copies/µL by probit analysis. Furthermore, analytical specificity testing revealed no cross-reactivity against a respiratory panel consisting of 33 viruses. Lastly, clinical evaluation of 466 nasopharyngeal specimens pre-verified by RT-PCR revealed a positive percentage agreement (PPA) of 94.7 %, negative percentage agreement (NPA) of 92.6 %, and overall agreement of 92.8 %. Moreover, Ct-stratified analysis demonstrated PPA of 100 % for Ct < 30, 88.9 % for 30 ≤ Ct ≤ 35, and 30 % for Ct > 35. These findings highlight the potential of GenHome® to deliver high clinical concordance with RT-PCR while retaining the ease-of-use and rapid turnaround critical for mPOCT. With its cartridge-integrated design and room-temperature-stable workflow, GenHome® is well-suited for widespread applications across diverse infectious-disease diagnostic applications.
SARS-CoV-2 (COVID-19)大流行凸显了快速准确的分子即时检测(mPOCT)的必要性。在这里,我们描述了GenHome®的开发,这是一个完全集成的一次性试剂盒平台,可在封闭系统工作流程中执行样品加载,直接核酸制备,环介导等温扩增(LAMP)和横向流读出,最大限度地减少用户干预并在30分钟内提供结果。作为该类型的第一个试剂盒,我们验证了针对SARS-CoV-2的ORF1ab基因的GenHome®SARS-CoV-2试剂盒。在优化条件(65°C, 20 min)下,GenHome®通过probit分析达到了194 copies/µL的检出限(LoD)。此外,分析特异性测试显示,对由33种病毒组成的呼吸组无交叉反应。最后,对466份经RT-PCR预验证的鼻咽标本进行临床评价,结果表明,阳性一致性百分比(PPA)为94.7%,阴性一致性百分比(NPA)为92.6%,总体一致性百分比为92.8%。此外,Ct分层分析显示,Ct <; 30的PPA为100%,30≤Ct≤35的PPA为88.9%,Ct >; 35的PPA为30%。这些发现突出了GenHome®在与RT-PCR提供高临床一致性的同时,保留了mPOCT的易用性和快速周转的潜力。凭借其墨盒集成设计和室温稳定的工作流程,GenHome®非常适合各种传染病诊断应用的广泛应用。
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引用次数: 0
Short-period temperature modulation for drift suppression and enhanced recognition performance in gas sensor 短周期温度调制用于气体传感器的漂移抑制和增强识别性能
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-06 DOI: 10.1016/j.snb.2026.139617
Lipeng Zhong , Kun Liang , Weifeng Liu , Zhijie Tang , Lanbo Wang , Sheng Hu , Feng Wang
Temperature modulation (TM) techniques have been widely employed in semiconductor gas sensors to enhance gas selectivity. However, inappropriate temperature control during TM can lead to drift-like effects, negatively impacting the accuracy of gas detection and concentration estimation. Existing drift-compensation methods exhibit high sensitivity to parameter tuning and limited adaptability, restricting their effectiveness in real-time sensing applications. In this study, we propose a hardware-level control strategy based on short-period temperature modulation, aiming to fundamentally suppress drift by compressing reaction time windows, thereby reducing thermal accumulation and residual formation. Experimental results indicate that, without any additional post-processing, the short-period (1 s) modulation achieves superior classification accuracy and concentration regression performance compared with the conventional long-period (40 s) modulation. Specifically, concentration regression error is reduced by approximately 68% on average. Even when compared with the algorithmically compensated 40 s dataset, regression error is further decreased by around 10%. This research provides not only a systematic parameter-optimization framework for TM cycle design but also a practical hardware solution for developing artificial olfactory systems characterized by high stability and minimal drift.
温度调制技术被广泛应用于半导体气体传感器中,以提高气体的选择性。然而,在TM过程中,温度控制不当会导致漂移效应,对气体检测和浓度估计的准确性产生负面影响。现有的漂移补偿方法对参数整定灵敏度高,自适应能力有限,制约了其在实时传感应用中的有效性。在本研究中,我们提出了一种基于短周期温度调制的硬件级控制策略,旨在通过压缩反应时间窗口从根本上抑制漂移,从而减少热积累和残余形成。实验结果表明,与传统的长周期(40 s)调制相比,短周期(1 s)调制在不进行任何后处理的情况下,具有更好的分类精度和浓度回归性能。具体来说,浓度回归误差平均降低了约68%。即使与经过算法补偿的40 s数据集相比,回归误差也进一步降低了10%左右。本研究不仅为TM循环设计提供了系统的参数优化框架,而且为开发高稳定性、最小漂移的人工嗅觉系统提供了实用的硬件解决方案。
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引用次数: 0
Silver aerogel-confined gold nanoclusters as electrochemiluminescence emitter and co-reaction promoter integrated with enzyme-free catalytic DNA amplification for ultrasensitive detection of aflatoxin B1 银气凝胶约束金纳米团簇作为电化学发光发射器和协同反应启动子集成无酶催化DNA扩增用于黄曲霉毒素B1的超灵敏检测
IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI: 10.1016/j.snb.2026.139599
Dehao Jia , Yu Du , Jingshuai Li , Shu-yuan Liu , Jingui Chen , Binnan Shi , Xuejing Liu , Rui Feng , Qin Wei
Gold nanoclusters (AuNCs) have garnered attention for their unique optical properties and biocompatibility, positioning them as promising electrochemiluminescence (ECL) emitters. However, the low ECL efficiency resulting from ligand rotation significantly hinders their broader application in biosensing technologies. Herein, AuNCs were loaded into silver aerogels (Ag AGs) via the synergistic aggregation of Ag AGs and citric acid (CA), yielding the ECL emitter (CA/AuNCs@Ag AGs) with integrated catalytic and luminescent properties. Firstly, Ag AGs could effectively aggregate AuNCs, which hindered the free rotation of AuNCs ligands, thereby reducing nonradiative energy dissipation and enhancing ECL efficiency. Secondly, Ag AGs could act as a co-reactant accelerator by catalyzing the conversion of more persulfate ions (S2O82-) to sulfate radicals (SO4•-), thereby further enhancing the ECL intensity. Additionally, an enzyme-free dual-cycle strategy was designed to efficiently correlate trace amounts of aflatoxin B1 (AFB1) with the generation of abundant quencher-bearing DNA strands through the catalytic hairpin assembly reaction, while simultaneously achieving ultrasensitive detection of AFB1 via highly efficient ECL resonance energy transfer. The developed biosensor exhibited a wide linear range from 1 pg/mL to 100 ng/mL and an impressive low detection limit of 0.23 pg/mL. This method not only provides a new idea for the development of high-performance ECL emitters but also possesses potential application in the field of trace biomarker detection.
金纳米团簇(aunc)因其独特的光学特性和生物相容性而受到人们的关注,将其定位为有前途的电化学发光(ECL)发射器。然而,由于配体旋转导致的低ECL效率严重阻碍了它们在生物传感技术中的广泛应用。通过Ag Ag和柠檬酸(CA)的协同聚集,将aunc装载到银气凝胶(Ag Ag)中,得到具有催化和发光性能的ECL发射器(CA/AuNCs@Ag AGs)。首先,Ag Ag可以有效聚集AuNCs,阻碍AuNCs配体的自由旋转,从而减少非辐射能量耗散,提高ECL效率。其次,Ag Ag可以作为助反应物促进剂,催化更多的过硫酸盐离子(S2O82-)转化为硫酸盐自由基(SO4•-),从而进一步提高ECL强度。此外,设计了一种无酶双循环策略,通过催化发夹组装反应有效地将痕量黄曲霉毒素B1 (AFB1)与丰富的承载猝灭剂的DNA链相关联,同时通过高效的ECL共振能量转移实现对AFB1的超灵敏检测。所开发的生物传感器具有从1 pg/mL到100 ng/mL的宽线性范围和令人印象深刻的低检测限0.23 pg/mL。该方法不仅为高性能ECL发射器的开发提供了新的思路,而且在痕量生物标志物检测领域具有潜在的应用前景。
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Sensors and Actuators B: Chemical
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