Sensors and Actuators B: Chemical最新文献

英文中文

An intelligent sensing array for thermal runaway characteristic gas concentration prediction based on SACNN-Mamba

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-04 DOI: 10.1016/j.snb.2025.137368

Meng Tang, Xin Zhang, Chang Zhang, Tongbin Chen, Xinxin Yan, Jie Zou, Wanlei Gao, Qinghui Jin, Jiawen Jian

To address the issue of cross-sensitivity when using gas signals for early warning of thermal runaway, an efficient algorithm based on the intelligent sensing array is proposed. The algorithmic model introduced in this paper is a fusion model that incorporates a feature self-attention module, a 1DCNN, and a Mamba module, aiming to enhance the regression prediction accuracy of the intelligent sensing array for gas mixture concentrations. The study demonstrates the effectiveness of our fusion network model in accurately predicting the concentrations of various target gases (such as H₂, CO, and C₂H₄) in gas mixtures. The coefficients of determination (R²) were 99.74 %, 99.45 %, and 99.48 % respectively, indicating that the model fits the sensor data very well and can predict changes in the data with high accuracy. The Root Mean Square Errors (RMSE) were 2.3514, 4.1752, and 3.7164, respectively. The Mean Absolute Errors (MAE) were 1.4398, 2.3846, and 2.5088, respectively. Additionally, the Symmetric Mean Absolute Percentage Errors (SMAPE) were 2.1212, 2.6272, and 2.6515. These values indicate that the model has high predictive accuracy and demonstrates good generality and robustness. The method proposed in this work holds significant potential for application in the field of gas warning for thermal runaway in lithium batteries.

{"title":"An intelligent sensing array for thermal runaway characteristic gas concentration prediction based on SACNN-Mamba","authors":"Meng Tang, Xin Zhang, Chang Zhang, Tongbin Chen, Xinxin Yan, Jie Zou, Wanlei Gao, Qinghui Jin, Jiawen Jian","doi":"10.1016/j.snb.2025.137368","DOIUrl":"10.1016/j.snb.2025.137368","url":null,"abstract":"<div><div>To address the issue of cross-sensitivity when using gas signals for early warning of thermal runaway, an efficient algorithm based on the intelligent sensing array is proposed. The algorithmic model introduced in this paper is a fusion model that incorporates a feature self-attention module, a 1DCNN, and a Mamba module, aiming to enhance the regression prediction accuracy of the intelligent sensing array for gas mixture concentrations. The study demonstrates the effectiveness of our fusion network model in accurately predicting the concentrations of various target gases (such as H<sub>2</sub>, CO, and C<sub>2</sub>H<sub>4</sub>) in gas mixtures. The coefficients of determination (R²) were 99.74 %, 99.45 %, and 99.48 % respectively, indicating that the model fits the sensor data very well and can predict changes in the data with high accuracy. The Root Mean Square Errors (RMSE) were 2.3514, 4.1752, and 3.7164, respectively. The Mean Absolute Errors (MAE) were 1.4398, 2.3846, and 2.5088, respectively. Additionally, the Symmetric Mean Absolute Percentage Errors (SMAPE) were 2.1212, 2.6272, and 2.6515. These values indicate that the model has high predictive accuracy and demonstrates good generality and robustness. The method proposed in this work holds significant potential for application in the field of gas warning for thermal runaway in lithium batteries.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137368"},"PeriodicalIF":8.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophobicity-promoted humidity-resistant ethanol sensors based on PTFE/Au/WO3 composite films

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-04 DOI: 10.1016/j.snb.2025.137386

Xiaojie Zhu , Xueting Chang , Yingchang Jiang , Weixiang Gao , Shibin Sun

The ability of hydrophobic surfaces to repel water make them attractive for preparing humidity-resistant gas-sensing films. Herein, we deposited the Au nanoparticles and the polytetrafluoroethylene (PTFE) film onto the WO₃ film sequentially to form the PTFE/Au/WO₃ composite films by using methods of ion beam sputtering and radio-frequency (RF) magnetron sputtering. The PTFE/Au/WO₃ composite films-based gas sensors exhibited high sensitivity towards ethanol with fast response/recovery rate, wide detection range, good selectivity, and high stability. Due to the hydrophobic feature of the PTFE film, the PTFE/Au/WO₃ composite films-based gas sensors demonstrated promising humidity-tolerant properties, which achieved a high response retention of as high as 88.7 % as the relative humidity (RH) increased from 30 % to 90 %. This work provides a new strategy for the development of metal oxide semiconductor (MOS)-based gas sensors that can work effectively under high humidity.

引用次数: 0

Electrical and fluorescent sensing-based dual-functional detection strategy for ultrasensitive antibiotics analysis

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-04 DOI: 10.1016/j.snb.2025.137384

Xiaojie Wei , Tian Tao , Ziwei Ye , Qiuju Li , Zhuo Li , Shun Mao

Kanamycin (KAN), a typical aminoglycoside antibiotic, has been frequently found in the environment, which causes threats to human health and ecosystems. Ultrasensitive and reliable antibiotic detection strategies are urgently needed. In this study, we propose a dual-functional MXene-based sensing strategy for antibiotic analysis. The sensing platform is fabricated by extended-gate field-effect transistor (EG-FET) with a commercial MOSFET and an extended gate as the sensing electrode. Through electrostatic interaction, Ti₃C₂T_x MXene nanosheets are assembled on ITO glass gate and double-stranded DNA (dsDNA) is modified on MXene surface. The dsDNA is composed of ssDNA and its complementary strand (cs-DNA). In particular, the ssDNA is the specific recognition element for KAN. KAN can compete with csDNA and disrupt the base pairing of dsDNA, causing the release of csDNA. Relying on the EG-FET sensing structure, a fluorescence detection strategy is also developed based on the quenching process of fluorophore (6-Carboxyfluorescein, 6-FAM) labeled cs-DNA (6-FAM-csDNA) on Ti₃C₂T_x MXene, in which the fluorescence intensity of 6-FAM is used as the signal for detecting KAN. This dual-functional MXene-based sensor offers both current response and fluorescence response signals in KAN detection. The reported sensor achieves an ultrasensitive detection performance for KAN with a detection limit of 6.44 fM. The sensor's ability to detect KAN in real water samples further demonstrates its practical application potential in complex environment. This work provides a novel dual-functional strategy for sensitive and highly specific detection of antibiotics, addressing some of the key obstacles in antibiotics detection in various applications.

{"title":"Electrical and fluorescent sensing-based dual-functional detection strategy for ultrasensitive antibiotics analysis","authors":"Xiaojie Wei , Tian Tao , Ziwei Ye , Qiuju Li , Zhuo Li , Shun Mao","doi":"10.1016/j.snb.2025.137384","DOIUrl":"10.1016/j.snb.2025.137384","url":null,"abstract":"<div><div>Kanamycin (KAN), a typical aminoglycoside antibiotic, has been frequently found in the environment, which causes threats to human health and ecosystems. Ultrasensitive and reliable antibiotic detection strategies are urgently needed. In this study, we propose a dual-functional MXene-based sensing strategy for antibiotic analysis. The sensing platform is fabricated by extended-gate field-effect transistor (EG-FET) with a commercial MOSFET and an extended gate as the sensing electrode. Through electrostatic interaction, Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene nanosheets are assembled on ITO glass gate and double-stranded DNA (dsDNA) is modified on MXene surface. The dsDNA is composed of ssDNA and its complementary strand (cs-DNA). In particular, the ssDNA is the specific recognition element for KAN. KAN can compete with csDNA and disrupt the base pairing of dsDNA, causing the release of csDNA. Relying on the EG-FET sensing structure, a fluorescence detection strategy is also developed based on the quenching process of fluorophore (6-Carboxyfluorescein, 6-FAM) labeled cs-DNA (6-FAM-csDNA) on Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene, in which the fluorescence intensity of 6-FAM is used as the signal for detecting KAN. This dual-functional MXene-based sensor offers both current response and fluorescence response signals in KAN detection. The reported sensor achieves an ultrasensitive detection performance for KAN with a detection limit of 6.44 fM. The sensor's ability to detect KAN in real water samples further demonstrates its practical application potential in complex environment. This work provides a novel dual-functional strategy for sensitive and highly specific detection of antibiotics, addressing some of the key obstacles in antibiotics detection in various applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137384"},"PeriodicalIF":8.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Line excitation SERS spectroscopy using laser-induced graphene coated with silver nanoparticles

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-03 DOI: 10.1016/j.snb.2025.137375

Jiajun Li, Yunyun Mu, Guanwei Tao, Xinping Zhang

We report a line excitation scheme for surface enhanced Raman scattering (SERS) using a graphene substrate deposited with silver nanoparticles (AgNPs). Direct laser writing was employed for producing laser-induced graphene (LIG) layer on polyimide and electrochemical reaction was used to grow AgNPs onto the surface of LIG. In addition to the local-field enhancement on the plasmonic hotspots, the graphene-based charge-transfer and molecular adsorption properties make further contributions to the SERS mechanisms. Compared with conventional point excitation, the line excitation scheme allows much extended dynamic range of the excitation laser power before reaching the damage threshold of the target molecules, much enhanced Raman signal due to the integration over the focusing line, and high reliability/repeatability of the SERS signals. This also reduces significantly the sensitivity of the SERS signals to the randomly distributed nanostructures. Thus, much enlarged excitation area/volume for Raman interactions enables high stability of the signals with multiplied intensity through integration over the focusing line, as compared with point excitation scheme under the same excitation power density. The line excitation scheme shows a detection limit of 100 ppb in tracing melamine in water, attaining an enhancement factor of larger than 100, as compared with point excitation.

{"title":"Line excitation SERS spectroscopy using laser-induced graphene coated with silver nanoparticles","authors":"Jiajun Li, Yunyun Mu, Guanwei Tao, Xinping Zhang","doi":"10.1016/j.snb.2025.137375","DOIUrl":"10.1016/j.snb.2025.137375","url":null,"abstract":"<div><div>We report a line excitation scheme for surface enhanced Raman scattering (SERS) using a graphene substrate deposited with silver nanoparticles (AgNPs). Direct laser writing was employed for producing laser-induced graphene (LIG) layer on polyimide and electrochemical reaction was used to grow AgNPs onto the surface of LIG. In addition to the local-field enhancement on the plasmonic hotspots, the graphene-based charge-transfer and molecular adsorption properties make further contributions to the SERS mechanisms. Compared with conventional point excitation, the line excitation scheme allows much extended dynamic range of the excitation laser power before reaching the damage threshold of the target molecules, much enhanced Raman signal due to the integration over the focusing line, and high reliability/repeatability of the SERS signals. This also reduces significantly the sensitivity of the SERS signals to the randomly distributed nanostructures. Thus, much enlarged excitation area/volume for Raman interactions enables high stability of the signals with multiplied intensity through integration over the focusing line, as compared with point excitation scheme under the same excitation power density. The line excitation scheme shows a detection limit of 100 ppb in tracing melamine in water, attaining an enhancement factor of larger than 100, as compared with point excitation.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137375"},"PeriodicalIF":8.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitive and reversible sensing of oxygen based on transition metals doped quasi-2D layered perovskites with 4T1→6A1 luminescence

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-03 DOI: 10.1016/j.snb.2025.137382

Fangyuan Lin , Xuelian Liu , Min Ye , Jingwen Jin , Xi Chen

Lead halide perovskites (LHPs) with rich optical properties have shown good prospects in sensing applications through rational design of their composition and structure. Although luminescent LHPs have been proposed as emerging probes for oxygen gas, their various oxygen-sensitive optical properties are still providing new ideas for oxygen sensing research, and oxygen sensing performance of these materials also needs to be improved. Here, a new class of metal-doped LHPs with quasi-two-dimensional (2D) layered structure and ⁴T₁→⁶A₁ luminescence has been fabricated, and their oxygen sensing capability has been demonstrated. As a representative, the layered perovskite A₂CsPb₂Cl₇ with a wealth of accessible Mn²⁺ dopants exhibits a sensitive response to the change of oxygen contents (I₀/I₁₀₀ = 9.75). By analyzing the effect of molecular oxygen on this material during sensing, we highlight that oxygen sensing responses of Mn²⁺-doped quasi-2D LHP are derived from the excited state of ⁴T₁→⁶A₁ luminescence. Dynamic deactivation of Mn²⁺-d excited state by O₂ molecules results in rapid quenching of Mn²⁺ emission and a reversible sensing phenomenon. In addition, Fe³⁺ dopants with the same ⁴T₁→⁶A₁ luminescence are introduced into the quasi-2D layered perovskite, so the possible mechanism has been further supported by similar oxygen sensing behaviors of Fe³⁺ emission. In our perception, above results make these perovskites candidates for oxygen sensing materials, for example, linear response was achieved at normal oxygen levels from 0 % to 21 %. Therefore, this work shows a new oxygen sensing platform based on the quasi-2D layered LHPs with ⁴T₁→⁶A₁ luminescence.

{"title":"Sensitive and reversible sensing of oxygen based on transition metals doped quasi-2D layered perovskites with 4T1→6A1 luminescence","authors":"Fangyuan Lin , Xuelian Liu , Min Ye , Jingwen Jin , Xi Chen","doi":"10.1016/j.snb.2025.137382","DOIUrl":"10.1016/j.snb.2025.137382","url":null,"abstract":"<div><div>Lead halide perovskites (LHPs) with rich optical properties have shown good prospects in sensing applications through rational design of their composition and structure. Although luminescent LHPs have been proposed as emerging probes for oxygen gas, their various oxygen-sensitive optical properties are still providing new ideas for oxygen sensing research, and oxygen sensing performance of these materials also needs to be improved. Here, a new class of metal-doped LHPs with quasi-two-dimensional (2D) layered structure and <sup>4</sup>T<sub>1</sub>→<sup>6</sup>A<sub>1</sub> luminescence has been fabricated, and their oxygen sensing capability has been demonstrated. As a representative, the layered perovskite A<sub>2</sub>CsPb<sub>2</sub>Cl<sub>7</sub> with a wealth of accessible Mn<sup>2+</sup> dopants exhibits a sensitive response to the change of oxygen contents (<em>I</em><sub><em>0</em></sub>/<em>I</em><sub><em>100</em></sub> = 9.75). By analyzing the effect of molecular oxygen on this material during sensing, we highlight that oxygen sensing responses of Mn<sup>2+</sup>-doped quasi-2D LHP are derived from the excited state of <sup>4</sup>T<sub>1</sub>→<sup>6</sup>A<sub>1</sub> luminescence. Dynamic deactivation of Mn<sup>2+</sup>-d excited state by O<sub>2</sub> molecules results in rapid quenching of Mn<sup>2+</sup> emission and a reversible sensing phenomenon. In addition, Fe<sup>3+</sup> dopants with the same <sup>4</sup>T<sub>1</sub>→<sup>6</sup>A<sub>1</sub> luminescence are introduced into the quasi-2D layered perovskite, so the possible mechanism has been further supported by similar oxygen sensing behaviors of Fe<sup>3+</sup> emission. In our perception, above results make these perovskites candidates for oxygen sensing materials, for example, linear response was achieved at normal oxygen levels from 0 % to 21 %. Therefore, this work shows a new oxygen sensing platform based on the quasi-2D layered LHPs with <sup>4</sup>T<sub>1</sub>→<sup>6</sup>A<sub>1</sub> luminescence.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137382"},"PeriodicalIF":8.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of multimeric peptide-MHC with SpyCatcher modules for antigen-specific T cell detection

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-03 DOI: 10.1016/j.snb.2025.137342

Xiangyao Wang , Mengyu Zhang , Enli Zhang , Qiwei Wang , Yiqing Guo , Dingfan Xu , Congran Yue , Haozhe Cui , Zhiming Zhao , Sheng Ye , Si Liu

Peptide-major histocompatibility complex (pMHC) multimers, most commonly used in streptavidin-based tetrameric form, are exceptional for detecting, isolating, and analyzing antigen-specific T cells. However, classical pMHC tetramer staining methods may not detect fully functional T-cells with lower-affinity T-cell receptors (TCRs), which are common in antitumor and autoimmune responses. This limitation has driven the innovation of new methods to improve pMHC binding through multivalent scaffolds, thereby increasing the avidity of weak TCR-pMHC interactions. In this study, we present a novel method for creating multimeric pMHC complexes using the SpyCatcher/SpyTag system. Our approach simplifies the multimer production process by eliminating biotinylation steps, instead employing SpyTag technology for efficient assembly. The method allows for the production of MHC molecules with SpyTags, which can be coupled to various SpyCatcher variants, enabling diverse oligomeric configurations. Our research demonstrates that these novel multimeric pMHC complexes significantly enhance the binding avidity for low-affinity antigen-specific TCRs compared to classical tetramers. This advancement presents a versatile platform for T cell response studies across diverse immunological contexts, offering advantages in specificity, stability, and scalability for both basic research and clinical applications.

{"title":"Preparation of multimeric peptide-MHC with SpyCatcher modules for antigen-specific T cell detection","authors":"Xiangyao Wang , Mengyu Zhang , Enli Zhang , Qiwei Wang , Yiqing Guo , Dingfan Xu , Congran Yue , Haozhe Cui , Zhiming Zhao , Sheng Ye , Si Liu","doi":"10.1016/j.snb.2025.137342","DOIUrl":"10.1016/j.snb.2025.137342","url":null,"abstract":"<div><div>Peptide-major histocompatibility complex (pMHC) multimers, most commonly used in streptavidin-based tetrameric form, are exceptional for detecting, isolating, and analyzing antigen-specific T cells. However, classical pMHC tetramer staining methods may not detect fully functional T-cells with lower-affinity T-cell receptors (TCRs), which are common in antitumor and autoimmune responses. This limitation has driven the innovation of new methods to improve pMHC binding through multivalent scaffolds, thereby increasing the avidity of weak TCR-pMHC interactions. In this study, we present a novel method for creating multimeric pMHC complexes using the SpyCatcher/SpyTag system. Our approach simplifies the multimer production process by eliminating biotinylation steps, instead employing SpyTag technology for efficient assembly. The method allows for the production of MHC molecules with SpyTags, which can be coupled to various SpyCatcher variants, enabling diverse oligomeric configurations. Our research demonstrates that these novel multimeric pMHC complexes significantly enhance the binding avidity for low-affinity antigen-specific TCRs compared to classical tetramers. This advancement presents a versatile platform for T cell response studies across diverse immunological contexts, offering advantages in specificity, stability, and scalability for both basic research and clinical applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137342"},"PeriodicalIF":8.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeing is Believing: Facile Amphiphilic AIEgen Unveils Selective and Ultrafast Wash-Free Dead Cell Imaging

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-03 DOI: 10.1016/j.snb.2025.137383

Kaixin Yang , Yuxin Yang , Leilei Si , Weihan Guo , Guosheng Zhang , Guomin Xia , Hongming Wang

The differentiation between live and dead cells is essential for both pharmacological and pathological research. However, current fluorescence probes face challenges due to their cumbersome methodologies and a lack of real-time imaging capabilities. In this study, we introduce an amphiphilic aggregation-induced emission luminogen (AIEgen) that incorporates two ammonium salts with the AIE building block of squaraine dyes. The resulting compound, SQ-N, exhibits negligible emission in aqueous and organic solvents as well as in the solid state, while displaying vivid orange fluorescence specifically in glycerol. This AIEgen has demonstrated the ability to selectively ‘light up’ dead cells with rapid, wash-free kinetics within seconds at room temperature, thereby presenting an ultrafast and user-friendly staining protocol. Additionally, the superior biocompatibility, long-term retention, and photostability of SQ-N render it more suitable for real-time and in situ monitoring of cell viability, thus serving as an effective alternative to commercial probes. Our work offers new insights into the amphiphilic AIEgen and its potential for the development of cellular imaging probes.

{"title":"Seeing is Believing: Facile Amphiphilic AIEgen Unveils Selective and Ultrafast Wash-Free Dead Cell Imaging","authors":"Kaixin Yang , Yuxin Yang , Leilei Si , Weihan Guo , Guosheng Zhang , Guomin Xia , Hongming Wang","doi":"10.1016/j.snb.2025.137383","DOIUrl":"10.1016/j.snb.2025.137383","url":null,"abstract":"<div><div>The differentiation between live and dead cells is essential for both pharmacological and pathological research. However, current fluorescence probes face challenges due to their cumbersome methodologies and a lack of real-time imaging capabilities. In this study, we introduce an amphiphilic aggregation-induced emission luminogen (AIEgen) that incorporates two ammonium salts with the AIE building block of squaraine dyes. The resulting compound, SQ-N, exhibits negligible emission in aqueous and organic solvents as well as in the solid state, while displaying vivid orange fluorescence specifically in glycerol. This AIEgen has demonstrated the ability to selectively ‘light up’ dead cells with rapid, wash-free kinetics within seconds at room temperature, thereby presenting an ultrafast and user-friendly staining protocol. Additionally, the superior biocompatibility, long-term retention, and photostability of SQ-N render it more suitable for real-time and in situ monitoring of cell viability, thus serving as an effective alternative to commercial probes. Our work offers new insights into the amphiphilic AIEgen and its potential for the development of cellular imaging probes.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137383"},"PeriodicalIF":8.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved ensemble learning enhanced serum fingerprinting spectroscopy for lung cancer diagnosis

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-03 DOI: 10.1016/j.snb.2025.137353

Zhejun Yang , Ren Zhang , Chenlei Cai , Hua Zhang , Hui Chen , Jilie Kong

The early diagnosis of lung cancer is crucial for improving patient prognosis, and liquid biopsy plays an important role in early lung cancer screening. In the field of liquid biopsy, label-free Surface-Enhanced Raman Scattering (SERS) possesses its unique advantages as it can provide comprehensive information about the insights into the chemical makeup of serum. However, the nonuniform SERS substrates poses challenges for reliable clinical diagnosis. We design a Surface Controlled SERS with Improved Ensemble Learning (SCSIEL) for lung cancer screening and diagnosis. This finely controlled SERS substrate ensures the uniformity of the surface and the high reproducibility of SERS spectra. The improved ensemble learning used in SCSIEL consists of a multi-layer structure which is inspired from the residual connection of deep learning networks. Although the framework is lightweight and integrates only a few simple base models, it achieves impressive results under the carefully constructed network. This SCSIEL system is also validated by direct analysis of clinical serum samples from 168 lung cancer patients and 100 healthy controls and the excellent performance is obtained with an area under the curve (AUC) of 97.0 % and accuracy of 93.4 %, which outperforms that of the clinical biomarkers for lung cancer. This SCSIEL is also explainable, which indicates the enhanced protein degradation in lung cancer. The SCSIEL method is a reliable and cost-effective method in the screen of lung cancer, shows great promise in clinical implementation.

{"title":"Improved ensemble learning enhanced serum fingerprinting spectroscopy for lung cancer diagnosis","authors":"Zhejun Yang , Ren Zhang , Chenlei Cai , Hua Zhang , Hui Chen , Jilie Kong","doi":"10.1016/j.snb.2025.137353","DOIUrl":"10.1016/j.snb.2025.137353","url":null,"abstract":"<div><div>The early diagnosis of lung cancer is crucial for improving patient prognosis, and liquid biopsy plays an important role in early lung cancer screening. In the field of liquid biopsy, label-free Surface-Enhanced Raman Scattering (SERS) possesses its unique advantages as it can provide comprehensive information about the insights into the chemical makeup of serum. However, the nonuniform SERS substrates poses challenges for reliable clinical diagnosis. We design a Surface Controlled SERS with Improved Ensemble Learning (<em>SCSIEL</em>) for lung cancer screening and diagnosis. This finely controlled SERS substrate ensures the uniformity of the surface and the high reproducibility of SERS spectra. The improved ensemble learning used in <em>SCSIEL</em> consists of a multi-layer structure which is inspired from the residual connection of deep learning networks. Although the framework is lightweight and integrates only a few simple base models, it achieves impressive results under the carefully constructed network. This <em>SCSIEL</em> system is also validated by direct analysis of clinical serum samples from 168 lung cancer patients and 100 healthy controls and the excellent performance is obtained with an area under the curve (AUC) of 97.0 % and accuracy of 93.4 %, which outperforms that of the clinical biomarkers for lung cancer. This <em>SCSIEL</em> is also explainable, which indicates the enhanced protein degradation in lung cancer. The <em>SCSIEL</em> method is a reliable and cost-effective method in the screen of lung cancer, shows great promise in clinical implementation.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137353"},"PeriodicalIF":8.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A target-triggering strategy for self-powered biosensor based on chemical nanogenerator

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-03 DOI: 10.1016/j.snb.2025.137361

Xinqi Luo, Hanxiao Chen, Ge Ling, Wenbo Yue, Bingbing Xie, Kexin Guo, Jing Xu

The self-powered sensing platform uses redox reactions to convert chemical nanogenerators into electrical energy, powering the system for target detection. In this work, a multi-dimensional hollow C@SnO₂ nanocomposite is designed as the electrode substrate and combined with the catalytic hairpin assembly (CHA) amplification strategy. This platform enables highly sensitive detection of the breast cancer marker miRNA-145. C@SnO₂ provides a large specific surface area and excellent electron transport properties, offering abundant enzyme active sites and improving electron transport efficiency. In the presence of miRNA-145, the CHA reaction cycle is triggered, anchoring CHA products to the electrode surface. These signal molecules then participate in the electrochemical reaction, amplifying the signal. Under optimized conditions, the platform demonstrates a linear response range from 1 fM to 10 nM, with a detection limit as low as 0.78 fM. The self-powered sensor enabling sensitive detection of miRNA-145 at low concentrations which is crucial for the early diagnosis of breast cancer. Additionally, this work integrates the self-powered sensing platform with commercial chips, ensuring stable performance and minimal signal fluctuations during long-term continuous monitoring, enabling portable and real-time target monitoring. This design expands the application range of self-powered biosensors and offers new approaches for field detection of other targets.

{"title":"A target-triggering strategy for self-powered biosensor based on chemical nanogenerator","authors":"Xinqi Luo, Hanxiao Chen, Ge Ling, Wenbo Yue, Bingbing Xie, Kexin Guo, Jing Xu","doi":"10.1016/j.snb.2025.137361","DOIUrl":"10.1016/j.snb.2025.137361","url":null,"abstract":"<div><div>The self-powered sensing platform uses redox reactions to convert chemical nanogenerators into electrical energy, powering the system for target detection. In this work, a multi-dimensional hollow C@SnO<sub>2</sub> nanocomposite is designed as the electrode substrate and combined with the catalytic hairpin assembly (CHA) amplification strategy. This platform enables highly sensitive detection of the breast cancer marker miRNA-145. C@SnO<sub>2</sub> provides a large specific surface area and excellent electron transport properties, offering abundant enzyme active sites and improving electron transport efficiency. In the presence of miRNA-145, the CHA reaction cycle is triggered, anchoring CHA products to the electrode surface. These signal molecules then participate in the electrochemical reaction, amplifying the signal. Under optimized conditions, the platform demonstrates a linear response range from 1 fM to 10 nM, with a detection limit as low as 0.78 fM. The self-powered sensor enabling sensitive detection of miRNA-145 at low concentrations which is crucial for the early diagnosis of breast cancer. Additionally, this work integrates the self-powered sensing platform with commercial chips, ensuring stable performance and minimal signal fluctuations during long-term continuous monitoring, enabling portable and real-time target monitoring. This design expands the application range of self-powered biosensors and offers new approaches for field detection of other targets.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137361"},"PeriodicalIF":8.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light/ultrasound enhance peroxidase activity of BaTiO3/graphdiyne/Au nanozyme for colorimetric detection of E. coli O157:H7

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-02 DOI: 10.1016/j.snb.2025.137378

Di Zhang , Haoxin Li , Kai Wang , Yujian Sun , Chenguang Wang , Yingying Wang , Qiang Bai , Tianzhi Yu , Zhugen Yang , Ning Sui , Lina Wang

In the past two decades, nanozymes have garnered increasing interest, however, their catalytic activity and efficacy still lag significantly behind that of natural enzymes, posing limitations on their utility in bioanalytical applications. In this study, we introduced a novel BaTiO₃/graphdiyne/Au (BGA) nanozyme that leverages surface plasmon resonance and piezoelectric effects to concurrently respond to light and ultrasound (US) stimulation, resulting in a 3.8-fold enhancement in peroxidase-like activity. Theoretical and experimental findings suggest that US stimulation induces lattice distortion in BaTiO₃, leading to the reversible conversion of CC bonds to CC bonds in graphdiyne. Consequently, the liberated electrons recombine with the hot holes produced by Au nanoparticles upon light excitation, thereby efficiently inhibiting the recombination of hot electron-hole pairs and substantially augmenting peroxidase-like activity. The BGA nanozyme was further configured as a detection platform for E. coli O157:H7. The sensor exhibited a broad linear range (1–10⁷ CFU mL⁻¹) and a low limit of detection of 7 CFU mL⁻¹. Moreover, the sensor exhibited exceptional applicability in the analysis of various real samples such as milk and lemon juice. This study presents a novel research framework for constructing high-activity nanozyme sensors responsive to external fields, offering significant potential in biological analysis, environmental surveillance, and food safety applications.

{"title":"Light/ultrasound enhance peroxidase activity of BaTiO3/graphdiyne/Au nanozyme for colorimetric detection of E. coli O157:H7","authors":"Di Zhang , Haoxin Li , Kai Wang , Yujian Sun , Chenguang Wang , Yingying Wang , Qiang Bai , Tianzhi Yu , Zhugen Yang , Ning Sui , Lina Wang","doi":"10.1016/j.snb.2025.137378","DOIUrl":"10.1016/j.snb.2025.137378","url":null,"abstract":"<div><div>In the past two decades, nanozymes have garnered increasing interest, however, their catalytic activity and efficacy still lag significantly behind that of natural enzymes, posing limitations on their utility in bioanalytical applications. In this study, we introduced a novel BaTiO<sub>3</sub>/graphdiyne/Au (BGA) nanozyme that leverages surface plasmon resonance and piezoelectric effects to concurrently respond to light and ultrasound (US) stimulation, resulting in a 3.8-fold enhancement in peroxidase-like activity. Theoretical and experimental findings suggest that US stimulation induces lattice distortion in BaTiO<sub>3</sub>, leading to the reversible conversion of C<img>C bonds to C<img>C bonds in graphdiyne. Consequently, the liberated electrons recombine with the hot holes produced by Au nanoparticles upon light excitation, thereby efficiently inhibiting the recombination of hot electron-hole pairs and substantially augmenting peroxidase-like activity. The BGA nanozyme was further configured as a detection platform for <em>E. coli</em> O157:H7. The sensor exhibited a broad linear range (1–10<sup>7</sup> CFU mL<sup>−1</sup>) and a low limit of detection of 7 CFU mL<sup>−1</sup>. Moreover, the sensor exhibited exceptional applicability in the analysis of various real samples such as milk and lemon juice. This study presents a novel research framework for constructing high-activity nanozyme sensors responsive to external fields, offering significant potential in biological analysis, environmental surveillance, and food safety applications.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"430 ","pages":"Article 137378"},"PeriodicalIF":8.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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