Sensors and Actuators B: Chemical最新文献_第3页

In-Situ monitoring via alternation of electroconductivity for solar-driven water purification based on thermo-reversible pore size of hydrogel

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-08 DOI: 10.1016/j.snb.2025.137413

Tae Min Kim , Akhmad Irhas Robby , Gibaek Lee , Byung Chan Lee , Benny Ryplida , Sung Young Park

A thermo-reversible electroconductive hydrogel composed of carbon dots (CDs)/TiO₂ fluorinated silica facilitates solar-driven water purification through pore size modulation, governed by a transition between hydrophobic and hydrophilic states. This transition is monitored by changes in electrical resistance. The inclusion of the photocatalyst TiO₂ in the CDs enhances hydrophilicity under visible light irradiation, enabling a reversible shift in surface affinity. This shift influences the volume transition of the CD-hydrogel within temperature ranges of 35 °C–55 °C and 0 °C–25 °C, corresponding to upper and lower critical solution temperatures, respectively. The hydrogel exhibits a temperature increase of 52.4 °C and a swelling ratio of 223 % upon solar light exposure. Water purification is achieved through water absorption and release cycles involving immersion and irradiation for 100 min, leading to a mass reduction of 2.435 kg/m². Moreover, bacterial contamination in water is purified and monitored through a measurable change in electrical resistance from 12.5 to 27.6 kΩ. These resistance variations enable real-time observation of water purification using electrochemical analysis and smartphone connectivity.

{"title":"In-Situ monitoring via alternation of electroconductivity for solar-driven water purification based on thermo-reversible pore size of hydrogel","authors":"Tae Min Kim , Akhmad Irhas Robby , Gibaek Lee , Byung Chan Lee , Benny Ryplida , Sung Young Park","doi":"10.1016/j.snb.2025.137413","DOIUrl":"10.1016/j.snb.2025.137413","url":null,"abstract":"<div><div>A thermo-reversible electroconductive hydrogel composed of carbon dots (CDs)/TiO<sub>2</sub> fluorinated silica facilitates solar-driven water purification through pore size modulation, governed by a transition between hydrophobic and hydrophilic states. This transition is monitored by changes in electrical resistance. The inclusion of the photocatalyst TiO<sub>2</sub> in the CDs enhances hydrophilicity under visible light irradiation, enabling a reversible shift in surface affinity. This shift influences the volume transition of the CD-hydrogel within temperature ranges of 35 °C–55 °C and 0 °C–25 °C, corresponding to upper and lower critical solution temperatures, respectively. The hydrogel exhibits a temperature increase of 52.4 °C and a swelling ratio of 223 % upon solar light exposure. Water purification is achieved through water absorption and release cycles involving immersion and irradiation for 100 min, leading to a mass reduction of 2.435 kg/m². Moreover, bacterial contamination in water is purified and monitored through a measurable change in electrical resistance from 12.5 to 27.6 kΩ. These resistance variations enable real-time observation of water purification using electrochemical analysis and smartphone connectivity.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137413"},"PeriodicalIF":8.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A platform of exogenous acoustic vortices for fabricating dimension-controllable cellular blocks

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-08 DOI: 10.1016/j.snb.2025.137376

Wonseok Choi , Hyeongmin Kim , Hyewon Park , Tae Young Yune , Inchan Youn , Sungmin Han

This article presents a method for fabricating an individual dimension-controllable cellular block, such as a spheroid and organoid, using exogenous and focused acoustic vortices. The interaction of phased-delayed ultrasonic signals generates acoustic waves characterized by helical wavefronts, thereby having the potential to transfer orbital angular momentum (OAM) into a suspension. A follow-up generated null region at the beam center provides trapping force to trap the free cells literally. This research contains comprehensive investigations of pulsing conditions and media compositions expected to affect the dimension quality of a single block. Comparative and systemic analyses of the pulsing parameters, such as pressure, duty cycles, and driving frequency, are first performed to identify the optimized conditions for fabricating a block. A collagen-supplemented media provides more stable tethering conditions for fabricated blocks by vortices in comparison to a normal medium. As fully demonstrated in the Results section, the quality of the dimension-controllable block is affected by total sonication time, as well as trapping force inherently restricted by the size of the null region. By understanding the comprehensive effects of both pulsing and cellular conditions on the fabrication procedure, this study aims to propose that OAM-based exogenous vortices are promising for various biological modeling research, with high tunability in their dimensions.

{"title":"A platform of exogenous acoustic vortices for fabricating dimension-controllable cellular blocks","authors":"Wonseok Choi , Hyeongmin Kim , Hyewon Park , Tae Young Yune , Inchan Youn , Sungmin Han","doi":"10.1016/j.snb.2025.137376","DOIUrl":"10.1016/j.snb.2025.137376","url":null,"abstract":"<div><div>This article presents a method for fabricating an individual dimension-controllable cellular block, such as a spheroid and organoid, using exogenous and focused acoustic vortices. The interaction of phased-delayed ultrasonic signals generates acoustic waves characterized by helical wavefronts, thereby having the potential to transfer orbital angular momentum (OAM) into a suspension. A follow-up generated null region at the beam center provides trapping force to trap the free cells literally. This research contains comprehensive investigations of pulsing conditions and media compositions expected to affect the dimension quality of a single block. Comparative and systemic analyses of the pulsing parameters, such as pressure, duty cycles, and driving frequency, are first performed to identify the optimized conditions for fabricating a block. A collagen-supplemented media provides more stable tethering conditions for fabricated blocks by vortices in comparison to a normal medium. As fully demonstrated in the Results section, the quality of the dimension-controllable block is affected by total sonication time, as well as trapping force inherently restricted by the size of the null region. By understanding the comprehensive effects of both pulsing and cellular conditions on the fabrication procedure, this study aims to propose that OAM-based exogenous vortices are promising for various biological modeling research, with high tunability in their dimensions.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137376"},"PeriodicalIF":8.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-assisted three-dimensional fluorescence for heavy metal multi-sensing

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-07 DOI: 10.1016/j.snb.2025.137385

Jiao Chen , Xiaolong Xiong , Jingru Ye , Xinjia Shuai , Jun Zhou , Qingqing Liu , Chengzhi Huang , Hui Liu

Heavy metal pollution is pervasive, complex, and diverse, causing lasting and potentially toxic effects on human health. Therefore, it is necessary to develop high-throughput detection of heavy metals. In this work, we proposed a machine learning-based three-dimensional fluorescent sensor strategy for effective detection of heavy metal pollution. Specifically, a multi-emitting fluorescent "chemical nose/tongue" sensor was first constructed with two different colored CDs and 5,10,15,20-tetrakis(4-trimethylamino) phenyl porphyrin (TAPP) for discriminating nine heavy metals, and then the fluorescence fingerprints were obtained based on the changes in the three-dimensional fluorescence spectra influenced by various heavy metals. The results demonstrated that the sensor easily and rapidly discriminated the categories and concentrations of multiple single heavy metal ions and binary mixed heavy metal ions within the concentration range of 10 μM–0.5 mM. Subsequently, the data input way was optimized, and the results showed that the accuracy of image recognition in predicting categories and concentrations of heavy metal ions was 75.1 % and 64.4 %, and the accuracy of data recognition was 97.8 % and 100 %. After optimizing the learning model, the Random Forest (RF) model can predict the categories and concentrations of a binary heavy metal mixture with accuracies of 100 % and 91.8 %, respectively. In addition, machine learning-assisted fluorescent sensors showed promising applications in real tap water and river samples. In conclusion, compared to previous analysis methods, this approach achieved qualitative and quantitative analysis of heavy metals in complex environments through three-dimensional fluorescence spectra combined with the ML strategy. Notably, the sensor did not involve cumbersome synthesis of multiple sensing channels, making it easy to construct and cost-effective.

{"title":"Machine learning-assisted three-dimensional fluorescence for heavy metal multi-sensing","authors":"Jiao Chen , Xiaolong Xiong , Jingru Ye , Xinjia Shuai , Jun Zhou , Qingqing Liu , Chengzhi Huang , Hui Liu","doi":"10.1016/j.snb.2025.137385","DOIUrl":"10.1016/j.snb.2025.137385","url":null,"abstract":"<div><div>Heavy metal pollution is pervasive, complex, and diverse, causing lasting and potentially toxic effects on human health. Therefore, it is necessary to develop high-throughput detection of heavy metals. In this work, we proposed a machine learning-based three-dimensional fluorescent sensor strategy for effective detection of heavy metal pollution. Specifically, a multi-emitting fluorescent \"chemical nose/tongue\" sensor was first constructed with two different colored CDs and 5,10,15,20-tetrakis(4-trimethylamino) phenyl porphyrin (TAPP) for discriminating nine heavy metals, and then the fluorescence fingerprints were obtained based on the changes in the three-dimensional fluorescence spectra influenced by various heavy metals. The results demonstrated that the sensor easily and rapidly discriminated the categories and concentrations of multiple single heavy metal ions and binary mixed heavy metal ions within the concentration range of 10 μM–0.5 mM. Subsequently, the data input way was optimized, and the results showed that the accuracy of image recognition in predicting categories and concentrations of heavy metal ions was 75.1 % and 64.4 %, and the accuracy of data recognition was 97.8 % and 100 %. After optimizing the learning model, the Random Forest (RF) model can predict the categories and concentrations of a binary heavy metal mixture with accuracies of 100 % and 91.8 %, respectively. In addition, machine learning-assisted fluorescent sensors showed promising applications in real tap water and river samples. In conclusion, compared to previous analysis methods, this approach achieved qualitative and quantitative analysis of heavy metals in complex environments through three-dimensional fluorescence spectra combined with the ML strategy. Notably, the sensor did not involve cumbersome synthesis of multiple sensing channels, making it easy to construct and cost-effective.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137385"},"PeriodicalIF":8.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143258225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-step process for ultrasensitive detection of mercuric ions using nanoparticle formation and single-entity electrochemistry

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-07 DOI: 10.1016/j.snb.2025.137412

Abinaya Ganesh , Gowrisankar Aruchamy , Kyungsoon Park , Byung-Kwon Kim

Mercuric ions (Hg²⁺) are common heavy-metal ions that pose a significant threat to human health due to their high toxicity. The detection of excessive concentrations of Hg²⁺ is critical and requires highly sensitive electrochemical techniques. A novel electrochemical sensing technique was employed for the detection of Hg²⁺. This study emphasizes the use of single-entity electrochemistry (SEE) for the one-step synthesis and selective detection of nanoparticles in aqueous solutions. Importantly, this method does not require a catalyst or reducing agent for nanoparticle synthesis. The developed approach provides significant advantages over conventional techniques, such as increased sensitivity, improved selectivity, and the ability to detect low concentrations of 1 pM Hg²⁺ without modifying the electrode surface and the linear range for Hg²⁺ was obtained at 1 pM – 10 nM. This one-step synthesis and detection method is a reliable and promising tool for sensing trace heavy metals and studying the redox behavior of mercuric ions.

汞离子（Hg2+）是常见的重金属离子，因其毒性高而对人类健康构成严重威胁。检测过量的 Hg2+ 浓度至关重要，需要高灵敏度的电化学技术。本研究采用了一种新型电化学传感技术来检测 Hg2+。本研究强调使用单实体电化学（SEE）一步合成和选择性检测水溶液中的纳米粒子。重要的是，这种方法不需要催化剂或还原剂来合成纳米粒子。与传统技术相比，所开发的方法具有明显的优势，如灵敏度更高、选择性更好、无需修改电极表面即可检测 1 pM 的低浓度 Hg2+，且 Hg2+ 的线性范围为 1 pM - 10 nM。这种一步合成和检测方法是一种可靠而有前途的工具，可用于检测痕量重金属和研究汞离子的氧化还原行为。

{"title":"One-step process for ultrasensitive detection of mercuric ions using nanoparticle formation and single-entity electrochemistry","authors":"Abinaya Ganesh , Gowrisankar Aruchamy , Kyungsoon Park , Byung-Kwon Kim","doi":"10.1016/j.snb.2025.137412","DOIUrl":"10.1016/j.snb.2025.137412","url":null,"abstract":"<div><div>Mercuric ions (Hg<sup>2</sup><sup>+</sup>) are common heavy-metal ions that pose a significant threat to human health due to their high toxicity. The detection of excessive concentrations of Hg<sup>2+</sup> is critical and requires highly sensitive electrochemical techniques. A novel electrochemical sensing technique was employed for the detection of Hg<sup>2+</sup>. This study emphasizes the use of single-entity electrochemistry (SEE) for the one-step synthesis and selective detection of nanoparticles in aqueous solutions. Importantly, this method does not require a catalyst or reducing agent for nanoparticle synthesis. The developed approach provides significant advantages over conventional techniques, such as increased sensitivity, improved selectivity, and the ability to detect low concentrations of 1 pM Hg<sup>2+</sup> without modifying the electrode surface and the linear range for Hg<sup>2+</sup> was obtained at 1 pM – 10 nM. This one-step synthesis and detection method is a reliable and promising tool for sensing trace heavy metals and studying the redox behavior of mercuric ions.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137412"},"PeriodicalIF":8.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient handy DNA extraction from fungal spores using modified ZnO nano-rices for rapid pathogen detection

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-07 DOI: 10.1016/j.snb.2025.137409

Huifang Liu , Sun Min Lim , Kelun Zhang , Jaekwan Shin , Bonhan Koo , Chang Ock Park , Sung-Han Kim , Yong Shin

Pathogen infections present a significant threat to human health due to their widespread presence and high transmissibility. Historical evidence underscores the importance of timely pathogen identification and appropriate treatment, not only for individual health recovery but also for the broader impact on human development. In this study, we introduced the homobifunctional imidoester-modified ZnO Nano-Rices (HINRs) method, which enables handy lysis and DNA extraction from target fungal spores. This approach streamlines fungal nucleic acid extraction, allowing for the rapid acquisition of pure nucleic acids within 12 minutes. The HINRs display a uniform, rice grain-like morphology, with consistent dimethyl suberimidate (DMS) modification on the ZnO nano-rice surface, enhancing dispersion in solution through increased zeta potential and surface area to capture fungal spores and nucleic acids. The HINRs method simplifies nucleic acid extraction, making it suitable for clinical sputum collection and fungal infection detection. It retains over 95 % stability at room temperature for up to two years, outperforming commercial kits by 2–3 orders of magnitude in Aspergillus extraction and detection. Additionally, we emphasized practical applications by testing various clinical samples (blood, lung tissue, and sputum) as well as fruit and vegetable drinks for extraction and contamination monitoring. This advancement supports the development of portable, streamlined, and precise diagnostic technologies.

{"title":"Efficient handy DNA extraction from fungal spores using modified ZnO nano-rices for rapid pathogen detection","authors":"Huifang Liu , Sun Min Lim , Kelun Zhang , Jaekwan Shin , Bonhan Koo , Chang Ock Park , Sung-Han Kim , Yong Shin","doi":"10.1016/j.snb.2025.137409","DOIUrl":"10.1016/j.snb.2025.137409","url":null,"abstract":"<div><div>Pathogen infections present a significant threat to human health due to their widespread presence and high transmissibility. Historical evidence underscores the importance of timely pathogen identification and appropriate treatment, not only for individual health recovery but also for the broader impact on human development. In this study, we introduced the homobifunctional imidoester-modified ZnO Nano-Rices (HINRs) method, which enables handy lysis and DNA extraction from target fungal spores. This approach streamlines fungal nucleic acid extraction, allowing for the rapid acquisition of pure nucleic acids within 12 minutes. The HINRs display a uniform, rice grain-like morphology, with consistent dimethyl suberimidate (DMS) modification on the ZnO nano-rice surface, enhancing dispersion in solution through increased zeta potential and surface area to capture fungal spores and nucleic acids. The HINRs method simplifies nucleic acid extraction, making it suitable for clinical sputum collection and fungal infection detection. It retains over 95 % stability at room temperature for up to two years, outperforming commercial kits by 2–3 orders of magnitude in <em>Aspergillus</em> extraction and detection. Additionally, we emphasized practical applications by testing various clinical samples (blood, lung tissue, and sputum) as well as fruit and vegetable drinks for extraction and contamination monitoring. This advancement supports the development of portable, streamlined, and precise diagnostic technologies.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137409"},"PeriodicalIF":8.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aptamer-directed tyramide signal amplification for ultrasensitive detection of small extracellular vesicles for temporally heterogenous colorectal cancer

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-07 DOI: 10.1016/j.snb.2025.137411

Byung Seok Cha , Eun Sung Lee , Junhyeong Kim, Jinseo Son, Doyeon Kim, Seokjoon Kim, Ki Soo Park

Colorectal cancer (CRC) is the most common gastrointestinal neoplasm, with a significant global disease burden. Current diagnostic modalities for CRC largely involve invasive methods, limiting the early diagnosis of CRC. Tumor-derived small extracellular vesicles (sEVs) are extracellularly secreted nanoscale vesicles carrying various biomolecules with intercellular messages, which regulate tumor progression and metastasis. In this study, TEV6RB, a novel aptamer with a 37-nucleotide sequence specific to CRC sEVs, was developed via CRC Toggle sEVs Systematic Evolution of Ligands by EXponential enrichment (TEV-SELEX) using various Dukes' staging CRC cell-derived sEVs. TEV6RB, with a parallel G-quadruplex structure, exhibited high binding affinities for CRC sEVs with low nanomolar dissociation constants (K_d; 3.848, 5.904, and 5.234 nM for SW620, LS 174 T, and HT29 cells, respectively). By using TEV6RB aptamer and tyramide signal amplification, our aptamer-directed tyramide signal amplification system (APTSA) achieved ultrasensitive detection of CRC sEVs with limit-of-detection values of 3.6 × 10², 3.5 × 10³, and 8.4 × 10² particles/μL for SW620, LS 174 T, and HT29 cells, respectively. This system further validated its high specificity in distinguishing CRC sEVs from healthy and normal colon samples. Our system presents a potential liquid biopsy approach for sEVs-mediated diagnosis of CRC.

{"title":"Aptamer-directed tyramide signal amplification for ultrasensitive detection of small extracellular vesicles for temporally heterogenous colorectal cancer","authors":"Byung Seok Cha , Eun Sung Lee , Junhyeong Kim, Jinseo Son, Doyeon Kim, Seokjoon Kim, Ki Soo Park","doi":"10.1016/j.snb.2025.137411","DOIUrl":"10.1016/j.snb.2025.137411","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is the most common gastrointestinal neoplasm, with a significant global disease burden. Current diagnostic modalities for CRC largely involve invasive methods, limiting the early diagnosis of CRC. Tumor-derived small extracellular vesicles (sEVs) are extracellularly secreted nanoscale vesicles carrying various biomolecules with intercellular messages, which regulate tumor progression and metastasis. In this study, TEV6RB, a novel aptamer with a 37-nucleotide sequence specific to CRC sEVs, was developed via CRC Toggle sEVs Systematic Evolution of Ligands by EXponential enrichment (TEV-SELEX) using various Dukes' staging CRC cell-derived sEVs. TEV6RB, with a parallel G-quadruplex structure, exhibited high binding affinities for CRC sEVs with low nanomolar dissociation constants (<em>K</em><sub><em>d</em></sub>; 3.848, 5.904, and 5.234 nM for SW620, LS 174 T, and HT29 cells, respectively). By using TEV6RB aptamer and tyramide signal amplification, our aptamer-directed tyramide signal amplification system (APTSA) achieved ultrasensitive detection of CRC sEVs with limit-of-detection values of 3.6 × 10<sup>2</sup>, 3.5 × 10<sup>3</sup>, and 8.4 × 10<sup>2</sup> particles/μL for SW620, LS 174 T, and HT29 cells, respectively. This system further validated its high specificity in distinguishing CRC sEVs from healthy and normal colon samples. Our system presents a potential liquid biopsy approach for sEVs-mediated diagnosis of CRC.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137411"},"PeriodicalIF":8.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced response and recovery observed in CNTs gas sensor using ZnO/HfO2 bilayer memristor heater

IF 8.4 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-07 DOI: 10.1016/j.snb.2025.137403

Mohsin Ali, Doowon Lee, Ibtisam Ahmad, Myoungsu Chae, Kyeong Heon Kim, Hee–Dong Kim

In carbon nanotubes (CNTs) based gas sensors, external energy sources are used to enhance the response and recovery characteristics, However, they have significant energy consumption and are constrained by size limitations. In this work, to solve them, we propose a ZnO/HfO₂ bilayer–memristor heater (MH) embedded CNTs gas sensor. Firstly, when tuning the thickness of ZnO in the MH, we observed a thickness dependency in the response characteristic, which can be explained by the variation in the gap of the ruptured conduction filament (CF). As a result, the 70 nm–ZnO MH, which had the longest gap between the ruptured CF and the CNTs layer, demonstrated the highest response of 58.3%. This response is 54.1% higher than that of the conventional CNTs gas sensor. In addition, in a pulse recovery study, we observed that the MH–embedded CNTs gas sensor returned to its initial state within only 1 ms after gas detection, which is 35ⅹ10⁵ times faster than a conventional CNTs sensor. These results indicate that the heating caused by the MH can effectively raise the temperature of the insulator near its surface, meaning that MH can be a good candidate as a heater in the microscale gas sensors.

{"title":"Enhanced response and recovery observed in CNTs gas sensor using ZnO/HfO2 bilayer memristor heater","authors":"Mohsin Ali, Doowon Lee, Ibtisam Ahmad, Myoungsu Chae, Kyeong Heon Kim, Hee–Dong Kim","doi":"10.1016/j.snb.2025.137403","DOIUrl":"https://doi.org/10.1016/j.snb.2025.137403","url":null,"abstract":"In carbon nanotubes (CNTs) based gas sensors, external energy sources are used to enhance the response and recovery characteristics, However, they have significant energy consumption and are constrained by size limitations. In this work, to solve them, we propose a ZnO/HfO<sub>2</sub> bilayer–memristor heater (MH) embedded CNTs gas sensor. Firstly, when tuning the thickness of ZnO in the MH, we observed a thickness dependency in the response characteristic, which can be explained by the variation in the gap of the ruptured conduction filament (CF). As a result, the 70 nm–ZnO MH, which had the longest gap between the ruptured CF and the CNTs layer, demonstrated the highest response of 58.3%. This response is 54.1% higher than that of the conventional CNTs gas sensor. In addition, in a pulse recovery study, we observed that the MH–embedded CNTs gas sensor returned to its initial state within only 1 ms after gas detection, which is 35ⅹ10<sup>5</sup> times faster than a conventional CNTs sensor. These results indicate that the heating caused by the MH can effectively raise the temperature of the insulator near its surface, meaning that MH can be a good candidate as a heater in the microscale gas sensors.","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"79 4 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunable membrane penetration-directed signal amplification for electrochemical determination of matrix metalloproteinase-2 in cancer diagnosis

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-07 DOI: 10.1016/j.snb.2025.137410

Guozhang Zhou , Yizhang Wu , Yulin Xiong , Yue Cao , Wensheng Liu , Kai Zhang , Jing Zhao , Ming Tu

Cancer is now a leading cause of human death worldwide and discovering an underlying cancer risk is essential to enhance the survival rates of the patients. Herein, we report a facile and sensitive electrochemical biosensing method for the determination of matrix metalloproteinase-2 (MMP-2), a potential indicator in most solid tumors. The core of the method is the use of a well-designed peptide probe with tunable membrane penetration activity. Specifically, the membrane penetration activity of the peptide probe is initially inhibited by a blocking domain through electrostatic interaction. Once the probe is selectively recognized and cleaved by MMP-2, its membrane penetration activity is switched on, leading to large amounts of methylene blue molecules being released from liposomes. As a result, remarkably amplified electrochemical responses are obtained for the determination of target MMP-2. Under optimized conditions, our method has displayed a good sensing performance, showing a wider linear range from 50 fg/mL to 10 ng/mL and a low limit of detection at 13.3 fg/mL. Moreover, the method has been successfully applied to MMP-2 determination in the mimic tumor microenvironment and serum samples and proved the feasibility of the selective identification of cancer patients. Therefore, our method may suggest a potential use in the determination of protease-specific tumor biomarkers for pan-cancer screening.

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引用次数: 0

Universal, sensitive, and visual sandwich-type biosensor based on nanogold-catalyzed reduction and its application for detecting C-reactive protein in serum by a portable colorimeter

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-07 DOI: 10.1016/j.snb.2025.137408

Runhui Zhang , Huaze Shao , Xiumei Hu , Yongshi Liang , Hanren Chen , Shiquan Zheng , Lihong Liu

We proposed a low-cost, high sensitive and universal point-of-care testing method of different dimension biomarkers based on the target-mediated catalytic reduction suppression of double-sequence aptamers-modified gold nanoparticles (dsApts@AuNPs) and NaBH₄ on the organic dyes (T-AAND). Herein, carcinoembryonic antigen, alpha-fetoprotein, C-reactive protein (CRP), thrombin, lipopolysaccharide, Staphylococcus aureus, and Escherichia coli were chosen as model biomarkers and all successfully detected, with limit of detections of 6.5 pg/mL, 12.7 pg/mL, 79.7 pg/mL, 34.2 fM, 459 fM, 718 CFU/mL, and 830 CFU/mL, respectively. Remarkably, the assay is completed in a single EP tube within 40 minutes, with on-site quantification performed using a $70 portable colorimeter and the cost of reagents for each test is $0.75. The CRP levels of 31 patients and 11 healthy volunteers achieved with the latex-enhanced immunoturbidimetry were high consistency with those of the spectrophotometry (r = 0.9964) and the colorimeter (r = 0.9619), demonstrating the accuracy of the new method. In conclusion, the T-AAND integrated a colorimeter is a superior approach for detecting biomarkers, especially in resource-limited settings.

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引用次数: 0

Antibodies functionalized magnetic Fe-metal-organic framework based biosensor for electrochemical detection of tetanus neurotoxin

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical

Pub Date : 2025-02-06 DOI: 10.1016/j.snb.2025.137381

Sarita Devi , Soraya Riedel , Sarah Döring , Lukas Hiller , Archana Kaliyaraj Selva Kumar , Sabine Flemig , Chandan Singh , Zoltán Konthur , Vasile-Dan Hodoroaba , Rudolf J. Schneider

This work presents a metal-organic framework (MOF)-integrated microfluidic flow-cell (MFC) based immunodetection of the tetanus toxoid (TT) using electrochemical technique for the first time. The magnetic property of Fe-MOF helped to hold them on the working electrode at detection zone of MFC surpassing the requirement of additional conjugation chemistry, whereas the conductive property was utilized to observe the change in signal efficiency in the presence of TT. The one-pot hydrothermal synthesis of a magnetic and conductive iron-based MOF (Fe-MOF) was performed using the Fe^3 +/Fe²⁺ precursors as 1.2/1 mmol and dual ligands, i.e., tetrahydroxy-1,4-benzoquinone and 2-aminobenzene-1,4-dicarboxylic acid. The Fe-MOF was conjugated with L-phenylalanine (Fe-MOF/Phe) to increase its electric conductivity owing to the enhanced electron flow rate. The human monoclonal antibody SA13 against TT (anti-TT mAb) was conjugated on the Fe-MOF/Phe surface with the help of ethylenediamine (Fe-MOF/Phe/EDA/anti-TT mAb). The binding affinity of Fe-MOF/Phe/EDA/anti-TT mAb for the TT antigen was evaluated using cyclic voltammetry technique. The limit of detection of the Fe-MOF/Phe/EDA/anti-TT mAb-based biosensor for TT was 9.4 ng/ml in spiked buffer. This study shows the applicability of these Fe-MOFs in the detection of various other microbial toxins or other biomolecules.

{"title":"Antibodies functionalized magnetic Fe-metal-organic framework based biosensor for electrochemical detection of tetanus neurotoxin","authors":"Sarita Devi , Soraya Riedel , Sarah Döring , Lukas Hiller , Archana Kaliyaraj Selva Kumar , Sabine Flemig , Chandan Singh , Zoltán Konthur , Vasile-Dan Hodoroaba , Rudolf J. Schneider","doi":"10.1016/j.snb.2025.137381","DOIUrl":"10.1016/j.snb.2025.137381","url":null,"abstract":"<div><div>This work presents a metal-organic framework (MOF)-integrated microfluidic flow-cell (MFC) based immunodetection of the tetanus toxoid (TT) using electrochemical technique for the first time. The magnetic property of Fe-MOF helped to hold them on the working electrode at detection zone of MFC surpassing the requirement of additional conjugation chemistry, whereas the conductive property was utilized to observe the change in signal efficiency in the presence of TT. The one-pot hydrothermal synthesis of a magnetic and conductive iron-based MOF (Fe-MOF) was performed using the Fe<sup>3 +</sup>/Fe<sup>2+</sup> precursors as 1.2/1 mmol and dual ligands, i.e., tetrahydroxy-1,4-benzoquinone and 2-aminobenzene-1,4-dicarboxylic acid. The Fe-MOF was conjugated with L-phenylalanine (Fe-MOF/Phe) to increase its electric conductivity owing to the enhanced electron flow rate. The human monoclonal antibody SA13 against TT (anti-TT mAb) was conjugated on the Fe-MOF/Phe surface with the help of ethylenediamine (Fe-MOF/Phe/EDA/anti-TT mAb). The binding affinity of Fe-MOF/Phe/EDA/anti-TT mAb for the TT antigen was evaluated using cyclic voltammetry technique. The limit of detection of the Fe-MOF/Phe/EDA/anti-TT mAb-based biosensor for TT was 9.4 ng/ml in spiked buffer. This study shows the applicability of these Fe-MOFs in the detection of various other microbial toxins or other biomolecules.</div></div>","PeriodicalId":425,"journal":{"name":"Sensors and Actuators B: Chemical","volume":"431 ","pages":"Article 137381"},"PeriodicalIF":8.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0