Pub Date : 2022-12-01DOI: 10.32598/jpr.10.4.1048.1
Malic Tudor Karolina, Batinic Marijan, A. Višnja, Rogulj Marijana, Franic Simic Ivana, Zekic Tomas Sandra
Germ cell tumors (GCTs) are a heterogeneous group of neoplasms that arise from the primordial germ cells of the human embryo, which are normally destined to produce reproductive cells sperm, or ova. GCTs can be present in both gonadal GCTs and extragonadal GCT sites. Pediatric GCTs are relatively rare tumors with an incidence of 2%-3%. Primary mediastinal germ cell tumors GCTs are very rare extragonadal GCTs that arise in the anterior mediastinum. In this report, we present the case of a 16-year-old boy with primary seminoma arising in the anterior mediastinum. The patient presented with the symptoms of cough, fever, and chest tightness. CT finding was in favor of a large expansive process measuring 12.4x6.7x14.2 cm in the anterior mediastinum, accompanied by a conglomeration of hilar lymph nodes in the level of brachiocephalic veins juncture. Fine needle biopsy and core biopsy were performed transthoracically, under the control of MSCT. Based on histology and immunohistochemistry, the diagnosis of mediastinal germ cell tumor with immunophenotype of seminoma was made. The patient was treated with 4 cycles of chemotherapy by BEP protocol without significant side effects and toxicities. The patient remained disease-free for 16 months. The purpose of reporting this case is to confirm that chemotherapy with cisplatin-based regimens has markedly improved the outcome of adults and children with GCTs as well.
{"title":"A 16-year-old Adolescent With Mediastinal Seminoma: A Case Report and Literature Review","authors":"Malic Tudor Karolina, Batinic Marijan, A. Višnja, Rogulj Marijana, Franic Simic Ivana, Zekic Tomas Sandra","doi":"10.32598/jpr.10.4.1048.1","DOIUrl":"https://doi.org/10.32598/jpr.10.4.1048.1","url":null,"abstract":"Germ cell tumors (GCTs) are a heterogeneous group of neoplasms that arise from the primordial germ cells of the human embryo, which are normally destined to produce reproductive cells sperm, or ova. GCTs can be present in both gonadal GCTs and extragonadal GCT sites. Pediatric GCTs are relatively rare tumors with an incidence of 2%-3%. Primary mediastinal germ cell tumors GCTs are very rare extragonadal GCTs that arise in the anterior mediastinum. In this report, we present the case of a 16-year-old boy with primary seminoma arising in the anterior mediastinum. The patient presented with the symptoms of cough, fever, and chest tightness. CT finding was in favor of a large expansive process measuring 12.4x6.7x14.2 cm in the anterior mediastinum, accompanied by a conglomeration of hilar lymph nodes in the level of brachiocephalic veins juncture. Fine needle biopsy and core biopsy were performed transthoracically, under the control of MSCT. Based on histology and immunohistochemistry, the diagnosis of mediastinal germ cell tumor with immunophenotype of seminoma was made. The patient was treated with 4 cycles of chemotherapy by BEP protocol without significant side effects and toxicities. The patient remained disease-free for 16 months. The purpose of reporting this case is to confirm that chemotherapy with cisplatin-based regimens has markedly improved the outcome of adults and children with GCTs as well.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43517907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Early Childhood Caries (ECC) has many etiologies such as families’ socioeconomic status, parents’ education and awareness, prolonged and improper bottle or breastfeeding, consuming sweet foods and high-sugar diets, brushing techniques, immaturity of children’s immune system, family size, and Streptococcus mutans. Evidence Acquisition: The data used in our review were searched from articles published between 1950 to 2021 and using ECC, children, saliva, salivary biomarkers, salivary enzymes, salivary peptides, salivary proteins, and immunity as keywords, collected from official web pages (Scopus, PubMed, Embase, and Google scholar) and documents published from different international institutions. The search was limited to articles published in the English language. After screening the abstract, the full text of 194 related studies was reviewed. Finally, 78 most related studies were selected. Results and Conclusions: ECC-related salivary proteins and peptides are Proline-rich proteins, salivary mucins, Lactoferrin, immunoglobulins, Toll-like receptors, Lysozyme, Histatins, Statherin, Defensins, Calprotectin, and Cytokines. ECC-related enzymes are Amylase, Lysozyme, Lactoperoxidase, Alkaline phosphatase, Carbonic anhydrase VI, Lactate dehydrogenase, and Glucosyltransferase B. Immunity factors affecting ECC include IgA (sIgA), IgG, IgM, salivary mucins, Lactoferrin, TLRs, Histatins, Statins, Defensins, Calprotectin, Lysozyme, Lactoperoxidase, Cytokines and interleukins, Cathelicidin (LL-37), Agglutinin, Cysteine, and Neutrophils.
{"title":"Salivary Proteins, Enzymes and Immune Factors Associated With Early Childhood Caries: A Narrative Review","authors":"Negareh Salehabadi, Aaryousha Moallem Savasari, Azam Nahvi","doi":"10.32598/jpr.10.4.870.3","DOIUrl":"https://doi.org/10.32598/jpr.10.4.870.3","url":null,"abstract":"Background: Early Childhood Caries (ECC) has many etiologies such as families’ socioeconomic status, parents’ education and awareness, prolonged and improper bottle or breastfeeding, consuming sweet foods and high-sugar diets, brushing techniques, immaturity of children’s immune system, family size, and Streptococcus mutans. Evidence Acquisition: The data used in our review were searched from articles published between 1950 to 2021 and using ECC, children, saliva, salivary biomarkers, salivary enzymes, salivary peptides, salivary proteins, and immunity as keywords, collected from official web pages (Scopus, PubMed, Embase, and Google scholar) and documents published from different international institutions. The search was limited to articles published in the English language. After screening the abstract, the full text of 194 related studies was reviewed. Finally, 78 most related studies were selected. Results and Conclusions: ECC-related salivary proteins and peptides are Proline-rich proteins, salivary mucins, Lactoferrin, immunoglobulins, Toll-like receptors, Lysozyme, Histatins, Statherin, Defensins, Calprotectin, and Cytokines. ECC-related enzymes are Amylase, Lysozyme, Lactoperoxidase, Alkaline phosphatase, Carbonic anhydrase VI, Lactate dehydrogenase, and Glucosyltransferase B. Immunity factors affecting ECC include IgA (sIgA), IgG, IgM, salivary mucins, Lactoferrin, TLRs, Histatins, Statins, Defensins, Calprotectin, Lysozyme, Lactoperoxidase, Cytokines and interleukins, Cathelicidin (LL-37), Agglutinin, Cysteine, and Neutrophils.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44972502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.32598/jpr.10.4.1059.1
Peiman Nasri, S. Sadeghi, S. Hovsepian, R. Chegini, Shahrzad Soltani Esmaeili, Gelare Kiani
Background: Considering the chronic immunosuppression in Inflammatory Bowel Disease (IBD) patients, it is necessary to evaluate the course of COVID-19 in these patients. Studies have shown various results in adult IBD patients. This study aimed to find out the course of this infection in pediatric IBD patients. Methods: This was a systematic review study according to the PRISMA 2020 guideline. International databases including Scopus, PubMed, and the Web of Science were searched with a combination of “COVID-19” AND “IBD” or synonyms until October 16, 2021. Studies that have reported the outcomes of COVID-19 infection in patients less than 19 years of age were selected. Name of author, country, study duration and type, IBD type and drugs, and COVID-19 outcomes were extracted. Results: From the initially retrieved 2215 articles, finally 16 articles were eligible. Data from 1040 pediatric IBD patients were reported. Twenty-four patients were hospitalized, 5 developed patients multisystem inflammatory syndrome in children, and others had a mild disease course and were outpatient. Steroid use, severe IBD activity, and comorbidities were shown to increase risk of hospitalization and disease severity. Conclusions: COVID-19 is a benign and self-limited disease in pediatric IBD patients. Comorbidities, steroid use, and severe IBD activity affect the outcomes.
背景：考虑到炎症性肠病（IBD）患者的慢性免疫抑制，有必要评估这些患者的新冠肺炎病程。研究表明，成人IBD患者的结果各不相同。本研究旨在了解儿童IBD患者的这种感染过程。方法：这是一项根据PRISMA 2020指南进行的系统回顾性研究。包括Scopus、PubMed和Web of Science在内的国际数据库使用“新冠肺炎”和“IBD”或同义词的组合进行搜索，直到2021年10月16日。选择了报告19岁以下患者感染新冠肺炎结果的研究。提取作者姓名、国家、研究持续时间和类型、IBD类型和药物以及新冠肺炎结果。结果：从最初检索到的2215篇文章中，最终有16篇符合条件。报告了1040名儿童IBD患者的数据。24名患者住院治疗，5名患者出现儿童多系统炎症综合征，其他患者病程较轻，正在门诊治疗。类固醇的使用、严重的IBD活动和合并症被证明会增加住院风险和疾病严重程度。结论：新冠肺炎是小儿IBD患者的一种良性自限性疾病。合并症、类固醇使用和严重IBD活动会影响结果。
{"title":"COVID-19 in Children With Inflammatory Bowel Disease: A Systematic Review","authors":"Peiman Nasri, S. Sadeghi, S. Hovsepian, R. Chegini, Shahrzad Soltani Esmaeili, Gelare Kiani","doi":"10.32598/jpr.10.4.1059.1","DOIUrl":"https://doi.org/10.32598/jpr.10.4.1059.1","url":null,"abstract":"Background: Considering the chronic immunosuppression in Inflammatory Bowel Disease (IBD) patients, it is necessary to evaluate the course of COVID-19 in these patients. Studies have shown various results in adult IBD patients. This study aimed to find out the course of this infection in pediatric IBD patients. Methods: This was a systematic review study according to the PRISMA 2020 guideline. International databases including Scopus, PubMed, and the Web of Science were searched with a combination of “COVID-19” AND “IBD” or synonyms until October 16, 2021. Studies that have reported the outcomes of COVID-19 infection in patients less than 19 years of age were selected. Name of author, country, study duration and type, IBD type and drugs, and COVID-19 outcomes were extracted. Results: From the initially retrieved 2215 articles, finally 16 articles were eligible. Data from 1040 pediatric IBD patients were reported. Twenty-four patients were hospitalized, 5 developed patients multisystem inflammatory syndrome in children, and others had a mild disease course and were outpatient. Steroid use, severe IBD activity, and comorbidities were shown to increase risk of hospitalization and disease severity. Conclusions: COVID-19 is a benign and self-limited disease in pediatric IBD patients. Comorbidities, steroid use, and severe IBD activity affect the outcomes.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48963919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.32598/jpr.10.4.1051.2
B. Nazemi Salman, Nazila Biglar, M. Mirkeshavarz, G. Ansari
Background: Microcephalic Osteodysplastic Primordial Dwarfism type 2 (MOPD II) is a rare untreatable genetic disorder characterized by severe prenatal and postnatal growth retardation, microcephaly, bird-headed face (receding forehead and chin, a beaklike nose, and prominent eyes), skeletal abnormalities, abnormal dentition, abnormal hair and skin changes, high-pitched nasal voice, and an increased risk for insulin resistance and cerebrovascular disease. MOPDII is caused by mutations in the pericentrin gene and is inherited in an autosomal recessive manner. This study aims to report a MOPD II child patient. Case Presentation: A seven-year-old girl genetically diagnosed with MOPD II has been presented in this case report. Clinical, radiological, and laboratory findings with emphasis on oral features have been reported, and her dental problems management has also been described. Conclusions: MOPD II patients have a shorter life expectancy. The main health complications which need regular care include vascular changes of the central nervous system, diabetes mellitus, renal problems, blood pressure, cardiac pathologies, and hematologic profile. MOPD II patients have a high risk of caries because they consume soft and cariogenic foods due to microdontia, oligodontia, and an incompetent masticatory system. On the other hand, dental treatment for such patients can be very challenging. MOPD II cases and their families should be aware of the importance of oral hygiene and routine dental follow-ups.
{"title":"Clinical Findings and Dental Manifestations Associated With Microcephalic Osteodysplastic Primordial Dwarfism Type II: A Case Report","authors":"B. Nazemi Salman, Nazila Biglar, M. Mirkeshavarz, G. Ansari","doi":"10.32598/jpr.10.4.1051.2","DOIUrl":"https://doi.org/10.32598/jpr.10.4.1051.2","url":null,"abstract":"Background: Microcephalic Osteodysplastic Primordial Dwarfism type 2 (MOPD II) is a rare untreatable genetic disorder characterized by severe prenatal and postnatal growth retardation, microcephaly, bird-headed face (receding forehead and chin, a beaklike nose, and prominent eyes), skeletal abnormalities, abnormal dentition, abnormal hair and skin changes, high-pitched nasal voice, and an increased risk for insulin resistance and cerebrovascular disease. MOPDII is caused by mutations in the pericentrin gene and is inherited in an autosomal recessive manner. This study aims to report a MOPD II child patient. Case Presentation: A seven-year-old girl genetically diagnosed with MOPD II has been presented in this case report. Clinical, radiological, and laboratory findings with emphasis on oral features have been reported, and her dental problems management has also been described. Conclusions: MOPD II patients have a shorter life expectancy. The main health complications which need regular care include vascular changes of the central nervous system, diabetes mellitus, renal problems, blood pressure, cardiac pathologies, and hematologic profile. MOPD II patients have a high risk of caries because they consume soft and cariogenic foods due to microdontia, oligodontia, and an incompetent masticatory system. On the other hand, dental treatment for such patients can be very challenging. MOPD II cases and their families should be aware of the importance of oral hygiene and routine dental follow-ups.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42087996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiva Shadani, Fahimeh Ghasemi, Mahsa Kamali, Mohammad Reza Navaeifar, A. Alikhani, S. Alian, Ali Reza Davoudi Badabi, M. S. Rezai
Background: Rabies is a fatal and often neglected disease leading to encephalomyelitis following a bite by an infected mammal. According to the necessity of rabies disease in Iran, we present four cases of rabies virus infection. Case Presentation: We presented 4 cases of rabies virus infection hospitalized in different hospitals in Iran in 2021-2022. Three patients were male. The youngest patient was 6 years old and the oldest was 81 years old. In all 4 cases, RT-PCR detected the positive virus infection. Three cases received rabies immunoglobulin. All of them received at least one dose of rabies vaccination; but, unfortunately, all patients died. Conclusions: The present case series showed the necessity of early rabies vaccination and also the early organization of stray dogs in the community. Unfortunately, two cases were lost to follow-up. So, the population education and follow-up of suspected rabies patients must be taken seriously by healthcare facilities.
{"title":"Rabies Virus Infection: A Case Series and Literature Review","authors":"Shiva Shadani, Fahimeh Ghasemi, Mahsa Kamali, Mohammad Reza Navaeifar, A. Alikhani, S. Alian, Ali Reza Davoudi Badabi, M. S. Rezai","doi":"10.32598/jpr.10.4.369.5","DOIUrl":"https://doi.org/10.32598/jpr.10.4.369.5","url":null,"abstract":"Background: Rabies is a fatal and often neglected disease leading to encephalomyelitis following a bite by an infected mammal. According to the necessity of rabies disease in Iran, we present four cases of rabies virus infection. Case Presentation: We presented 4 cases of rabies virus infection hospitalized in different hospitals in Iran in 2021-2022. Three patients were male. The youngest patient was 6 years old and the oldest was 81 years old. In all 4 cases, RT-PCR detected the positive virus infection. Three cases received rabies immunoglobulin. All of them received at least one dose of rabies vaccination; but, unfortunately, all patients died. Conclusions: The present case series showed the necessity of early rabies vaccination and also the early organization of stray dogs in the community. Unfortunately, two cases were lost to follow-up. So, the population education and follow-up of suspected rabies patients must be taken seriously by healthcare facilities.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47299560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic Urticaria (CU) is a skin disorder characterized by wheal and flare with a duration of more than 6 weeks affecting 1%-2% of the population (more common in women). Thirty to 35% of cases of CU have angioedema [1]. The etiology of chronic spontaneous urticarial is not usually clear, 40%-50% are idiopathic and 30%-40% are autoimmune [2, 3]. Quality of life in CU is usually disturbed which has a direct relation with severity [4].
{"title":"Biologic Drugs Treatment of Chronic Urticaria","authors":"J. Ghaffari","doi":"10.32598/jpr.10.4.28.17","DOIUrl":"https://doi.org/10.32598/jpr.10.4.28.17","url":null,"abstract":"Chronic Urticaria (CU) is a skin disorder characterized by wheal and flare with a duration of more than 6 weeks affecting 1%-2% of the population (more common in women). Thirty to 35% of cases of CU have angioedema [1]. The etiology of chronic spontaneous urticarial is not usually clear, 40%-50% are idiopathic and 30%-40% are autoimmune [2, 3]. Quality of life in CU is usually disturbed which has a direct relation with severity [4].","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46152870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.32598/jpr.10.4.1053.1
Jasmine Al-Zahiri, Akanksha Kumar, A. Nair, Tabitha Watts
Background: Neonatal polycythemia is a condition that is incidentally encountered in clinical practice. It is characterized by elevated hemoglobin levels (above 22 g/dL) and hematocrit ratios above 65%. It is important to understand both the prevalence as well as the related risk factors of this condition as untreated preventable risk factors can result in the development of hyperviscosity syndromes leading to potential multiple organ failure. Prevalence and Risk Factors: Risk factors include the presence of twin-to-twin transfusion, pre-eclampsia, maternal hypertension, operator-dependent cord clamping, and the presence of co-morbid conditions in neonates. The prevalence of neonatal polycythemia varies among regions and factors that may affect this variation include elevation above sea level of the patient and the mother, management of perinatal conditions such as gestational diabetes mellitus, and the method of delivery. Conclusions: From this study, it is evident that not only do existing neonatal and maternal risk factors such as twin-to-twin transfusion syndrome and post-term deliveries, respectively, increase the risk of neonatal polycythemia but also the geographical and socioeconomic status are major factors. It is therefore imperative to conduct more thorough large-scale cohort studies to further understand the reasons for this.
{"title":"Prevalence of Neonatal Polycythemia and an Assessment of Its Related Risk Factors","authors":"Jasmine Al-Zahiri, Akanksha Kumar, A. Nair, Tabitha Watts","doi":"10.32598/jpr.10.4.1053.1","DOIUrl":"https://doi.org/10.32598/jpr.10.4.1053.1","url":null,"abstract":"Background: Neonatal polycythemia is a condition that is incidentally encountered in clinical practice. It is characterized by elevated hemoglobin levels (above 22 g/dL) and hematocrit ratios above 65%. It is important to understand both the prevalence as well as the related risk factors of this condition as untreated preventable risk factors can result in the development of hyperviscosity syndromes leading to potential multiple organ failure. Prevalence and Risk Factors: Risk factors include the presence of twin-to-twin transfusion, pre-eclampsia, maternal hypertension, operator-dependent cord clamping, and the presence of co-morbid conditions in neonates. The prevalence of neonatal polycythemia varies among regions and factors that may affect this variation include elevation above sea level of the patient and the mother, management of perinatal conditions such as gestational diabetes mellitus, and the method of delivery. Conclusions: From this study, it is evident that not only do existing neonatal and maternal risk factors such as twin-to-twin transfusion syndrome and post-term deliveries, respectively, increase the risk of neonatal polycythemia but also the geographical and socioeconomic status are major factors. It is therefore imperative to conduct more thorough large-scale cohort studies to further understand the reasons for this.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47556560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyyedeh Azade Hoseini Nouri, Manijeh Tabrizi, M. Zarkesh, A. Talebi, M. Shahrokhi, A. Hassanzadeh Rad, Setila Dalili, E. Kazemnezhad leili
Background and Objectives: Over the past three decades, the prevalence of overweight and obesity in children and adolescents has increased up to 3 times. Obesity is a multi-systemic medical problem affecting all socioeconomic statuses and increases the risk of other severe comorbidities even in childhood. In 50% of cases, there is a persistence of obesity from childhood into adulthood. This narrative review aimed to define the etiology, risk factors, prevention, and management of obesity in children. Methods: This narrative review was conducted through a literature search on articles in English with the keywords of pediatric obesity, child, overweight, and bariatric surgery in PubMed, Scopus, ISI Web of Sciences, Cochrane, and EMBASE databases from 2001 to 2021 for 4 categories of etiology, risk factors, prevention, and management of obesity in children. Scientific articles, systematic reviews, meta-analyses, consensus, recommendations, and international and national guidelines published on pediatric obesity were considered. Results: In this narrative review, we first assessed relevant articles to define childhood obesity and mention its etiologies. We then discussed the probability of persistent obesity from childhood into adulthood and intergenerational and perinatal transmission risks. We also noticed syndromic obesity, evaluation of childhood obesity, and its complications along with medical/surgical interventions. Conclusions: Metabolic programming in particular periods of life, such as before and during pregnancy, infancy, and at the age of rebound adiposity (5.5 years old), is necessary to prevent childhood obesity. Lifestyle changes, diet modifications, promoting exclusive breastfeeding, and increased activity are the main principles of preventing and managing obesity. It is prudent to rule out syndromic and endocrinologic causes of obesity in suspicious patients along with their management.
背景和目的:在过去三十年中，儿童和青少年中超重和肥胖的患病率增加了三倍。肥胖是一个影响所有社会经济地位的多系统医学问题，甚至在儿童时期也会增加其他严重合并症的风险。在50%的病例中，肥胖症从儿童期持续到成年期。本综述旨在明确儿童肥胖的病因、危险因素、预防和管理。方法:对2001 - 2021年PubMed、Scopus、ISI Web of Sciences、Cochrane和EMBASE数据库中以儿童肥胖、儿童、超重和减肥手术为关键词的英文文章进行文献检索，检索儿童肥胖的病因、危险因素、预防和管理4类。科学文章、系统综述、荟萃分析、共识、建议以及发表的关于儿童肥胖的国际和国家指南被考虑在内。结果:在这篇叙述性综述中，我们首先评估了相关的文章来定义儿童肥胖并提及其病因。然后我们讨论了从儿童期到成年期持续肥胖的可能性以及代际和围产期传播风险。我们还注意到综合征性肥胖、儿童肥胖的评估及其并发症以及医疗/手术干预。结论:在生命的特定时期，如怀孕前和怀孕期间，婴儿期和反弹肥胖年龄(5.5岁)，代谢规划是预防儿童肥胖的必要条件。改变生活方式、调整饮食、促进纯母乳喂养和增加活动是预防和管理肥胖的主要原则。谨慎的做法是排除可疑患者肥胖的综合征和内分泌原因，并对其进行管理。
{"title":"Management of Obesity in Children: A Narrative Review","authors":"Seyyedeh Azade Hoseini Nouri, Manijeh Tabrizi, M. Zarkesh, A. Talebi, M. Shahrokhi, A. Hassanzadeh Rad, Setila Dalili, E. Kazemnezhad leili","doi":"10.32598/jpr.10.4.584.5","DOIUrl":"https://doi.org/10.32598/jpr.10.4.584.5","url":null,"abstract":"Background and Objectives: Over the past three decades, the prevalence of overweight and obesity in children and adolescents has increased up to 3 times. Obesity is a multi-systemic medical problem affecting all socioeconomic statuses and increases the risk of other severe comorbidities even in childhood. In 50% of cases, there is a persistence of obesity from childhood into adulthood. This narrative review aimed to define the etiology, risk factors, prevention, and management of obesity in children. Methods: This narrative review was conducted through a literature search on articles in English with the keywords of pediatric obesity, child, overweight, and bariatric surgery in PubMed, Scopus, ISI Web of Sciences, Cochrane, and EMBASE databases from 2001 to 2021 for 4 categories of etiology, risk factors, prevention, and management of obesity in children. Scientific articles, systematic reviews, meta-analyses, consensus, recommendations, and international and national guidelines published on pediatric obesity were considered. Results: In this narrative review, we first assessed relevant articles to define childhood obesity and mention its etiologies. We then discussed the probability of persistent obesity from childhood into adulthood and intergenerational and perinatal transmission risks. We also noticed syndromic obesity, evaluation of childhood obesity, and its complications along with medical/surgical interventions. Conclusions: Metabolic programming in particular periods of life, such as before and during pregnancy, infancy, and at the age of rebound adiposity (5.5 years old), is necessary to prevent childhood obesity. Lifestyle changes, diet modifications, promoting exclusive breastfeeding, and increased activity are the main principles of preventing and managing obesity. It is prudent to rule out syndromic and endocrinologic causes of obesity in suspicious patients along with their management.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42181769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neda Mostofizadeh, M. Najafi, S. Hovsepian, Elham Hashemi Dehkordi, Nousin Rostampour, M. Hashemipour
Background: Lipodystrophy is the most common complication of insulin injection that has not been studied yet in children with Type 1 Diabetes Mellitus (T1DM) in Isfahan. Objectives: This study aimed to evaluate the prevalence of insulin injection-induced lipodystrophy based on related risk factors in children and adolescents with T1DM. Methods: In this cross-sectional study, children and adolescents aged less than 18 years with T1DM who referred to the endocrinology clinic of Imam Hossein Hospital in Isfahan, Iran, in 2019 were enrolled. The baseline, anthropometric, and T1DM-related characteristics of the patients were recorded. Lipodystrophy was diagnosed by clinical examination. The characteristics of patients with and without lipodystrophy were compared. The association between lipodystrophy and disease-related factors was investigated. Results: In this study, 194 patients with T1DM (88 boys and 106 girls) aged 3 to 18 years were evaluated. Lipodystrophy was diagnosed in 91 patients (46.9%), of which 64 patients (33%) had grade 1, 24 patients (12.4%) had grade 2, and 3 patients (1.5%) had grade 3 lipodystrophy. There was a significant difference in the frequency of lipodystrophy based on age, BMI, patient education, parent education, insulin injection site, duration of diabetes, injection site change, needle change, insulin dose, HbA1c, and hypoglycemia (P<0.05). Regression analysis indicated that there is a significant association between the presence of lipodystrophy and HbA1c (P<0.001, t=7.20), insulin dose (P<0.001, t=4.47), BMI (P<0.001, t= -3.78) and duration of T1DM (P=0.002, t=3.15). Conclusions: In this study, we reported a high prevalence of lipodystrophy among T1DM patients in Isfahan. From the studied risk factors, duration of diabetes, lower BMI, using a high dose of insulin, and uncontrolled diabetes (HbA1c>7) were the most important risk factors for lipodystrophy.
{"title":"Prevalence of Insulin Injection-induced Lipodystrophy and Associated Risk Factors in Children and Adolescents With Type 1 Diabetes Mellitus","authors":"Neda Mostofizadeh, M. Najafi, S. Hovsepian, Elham Hashemi Dehkordi, Nousin Rostampour, M. Hashemipour","doi":"10.32598/jpr.10.4.512.2","DOIUrl":"https://doi.org/10.32598/jpr.10.4.512.2","url":null,"abstract":"Background: Lipodystrophy is the most common complication of insulin injection that has not been studied yet in children with Type 1 Diabetes Mellitus (T1DM) in Isfahan. Objectives: This study aimed to evaluate the prevalence of insulin injection-induced lipodystrophy based on related risk factors in children and adolescents with T1DM. Methods: In this cross-sectional study, children and adolescents aged less than 18 years with T1DM who referred to the endocrinology clinic of Imam Hossein Hospital in Isfahan, Iran, in 2019 were enrolled. The baseline, anthropometric, and T1DM-related characteristics of the patients were recorded. Lipodystrophy was diagnosed by clinical examination. The characteristics of patients with and without lipodystrophy were compared. The association between lipodystrophy and disease-related factors was investigated. Results: In this study, 194 patients with T1DM (88 boys and 106 girls) aged 3 to 18 years were evaluated. Lipodystrophy was diagnosed in 91 patients (46.9%), of which 64 patients (33%) had grade 1, 24 patients (12.4%) had grade 2, and 3 patients (1.5%) had grade 3 lipodystrophy. There was a significant difference in the frequency of lipodystrophy based on age, BMI, patient education, parent education, insulin injection site, duration of diabetes, injection site change, needle change, insulin dose, HbA1c, and hypoglycemia (P<0.05). Regression analysis indicated that there is a significant association between the presence of lipodystrophy and HbA1c (P<0.001, t=7.20), insulin dose (P<0.001, t=4.47), BMI (P<0.001, t= -3.78) and duration of T1DM (P=0.002, t=3.15). Conclusions: In this study, we reported a high prevalence of lipodystrophy among T1DM patients in Isfahan. From the studied risk factors, duration of diabetes, lower BMI, using a high dose of insulin, and uncontrolled diabetes (HbA1c>7) were the most important risk factors for lipodystrophy.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47028917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.32598/jpr.10.3.1026.1
S. Hashemi, S. Hosseini, M. Moosazadeh, M. Shamspour, Reihaneh Hajizadeh-Zaker, Seyed Bagher Hashemi
Background: Eating disorders are among the deadliest psychiatric diseases that have become increasingly prevalent in different societies in recent years. Various biological, social, and psychological factors are involved in the emergence of different types of eating disorders. Several studies have been conducted by medical and non-medical researchers in Iran to estimate the prevalence of this disorder and its subcategories, which have been associated with different epidemiological methodologies and instruments and inconsistent results. Objectives: This study aims to statistically analyze all available findings to determine the total estimate of the prevalence of eating disorders in the general population of Iran and to investigate the reasons for the heterogenous results in previous studies. Methods: The articles were collected by searching the following databases: SID, Magiran, Irandoc, Iran Medex, PubMed, and Google Scholar. All studies evaluating the prevalence of eating disorders in any region of Iran from 1990 to the end of 2021 were included in the study. Meanwhile, articles that were irrelevant in terms of subject or methodology were excluded. Three researchers independently extracted the data from the articles based on a pre-prepared list that included the author’s name, study title, year of publication, journal name, city and study population, sample size, study instruments, and eating disorder prevalence. Results: The estimated point prevalence of any eating disorder in Iran was 22% (95% CI, 7%-38%). The estimated lifetime prevalence of eating disorder, anorexia nervosa, and bulimia nervosa was 1% (95% CI, 1%-2%), 1% (95% CI, 0%-1%), and 1% (95% CI, 0%-1%), respectively. Conclusions: The prevalence of eating disorders and its subcategories is much lower in Iran compared to high-income and developed countries. The available data are insufficient to determine the exact prevalence of this disorder in the general population, especially among Iranian men.
{"title":"Prevalence of Eating Disorders in Iran From Preschool to Old Age: A Systematic Review and Meta-analysis","authors":"S. Hashemi, S. Hosseini, M. Moosazadeh, M. Shamspour, Reihaneh Hajizadeh-Zaker, Seyed Bagher Hashemi","doi":"10.32598/jpr.10.3.1026.1","DOIUrl":"https://doi.org/10.32598/jpr.10.3.1026.1","url":null,"abstract":"Background: Eating disorders are among the deadliest psychiatric diseases that have become increasingly prevalent in different societies in recent years. Various biological, social, and psychological factors are involved in the emergence of different types of eating disorders. Several studies have been conducted by medical and non-medical researchers in Iran to estimate the prevalence of this disorder and its subcategories, which have been associated with different epidemiological methodologies and instruments and inconsistent results. Objectives: This study aims to statistically analyze all available findings to determine the total estimate of the prevalence of eating disorders in the general population of Iran and to investigate the reasons for the heterogenous results in previous studies. Methods: The articles were collected by searching the following databases: SID, Magiran, Irandoc, Iran Medex, PubMed, and Google Scholar. All studies evaluating the prevalence of eating disorders in any region of Iran from 1990 to the end of 2021 were included in the study. Meanwhile, articles that were irrelevant in terms of subject or methodology were excluded. Three researchers independently extracted the data from the articles based on a pre-prepared list that included the author’s name, study title, year of publication, journal name, city and study population, sample size, study instruments, and eating disorder prevalence. Results: The estimated point prevalence of any eating disorder in Iran was 22% (95% CI, 7%-38%). The estimated lifetime prevalence of eating disorder, anorexia nervosa, and bulimia nervosa was 1% (95% CI, 1%-2%), 1% (95% CI, 0%-1%), and 1% (95% CI, 0%-1%), respectively. Conclusions: The prevalence of eating disorders and its subcategories is much lower in Iran compared to high-income and developed countries. The available data are insufficient to determine the exact prevalence of this disorder in the general population, especially among Iranian men.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42019609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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