L. N. Altunal, Buket Erturk Sengel, A. Ozel, M. Aydın, A. Kadanalı
Objective: Tuberculosis (TB) is a significant public health problem that remains important worldwide. This study aimed to examine the demographic characteristics and clinical features of patients with extrapulmonary tuberculosis (EPTB) and also identify the comorbidities of EPTB. Our secondary aim was to compare tuberculous lymphadenitis (TBL) with other forms of EPTB. Patients and Methods: This single-center, retrospective, observational study was conducted on patients diagnosed with EPTB in a training hospital in Turkey between January 1, 2011 and December 31, 2020. The demographic characteristics and clinical features of the patients were examined. TBL cases were compared with other forms of EPTB cases. Results: The most common clinical form was TBL. Fever, night sweats, and accelerated erythrocyte sedimentation rate were significantly more common in the other forms of the EPTB group compared to TBL. The rate of tuberculin skin test positivity was significantly higher in patients with TBL. The complication rate was 3%, and mortality rate was 4% among all patients. Conclusions: Extrapulmonary tuberculosis should be considered in the differential diagnosis by evaluating the medical history of patients who present with organ-specific symptoms, especially in TB endemic countries. The clinic may differ according to the organ involvement. TBL may be seen with milder symptoms compared to other clinical forms.
{"title":"Demographic and microbiological characteristics of tuberculous lymphadenitis and other extrapulmonary tuberculosis cases","authors":"L. N. Altunal, Buket Erturk Sengel, A. Ozel, M. Aydın, A. Kadanalı","doi":"10.5472/marumj.1191093","DOIUrl":"https://doi.org/10.5472/marumj.1191093","url":null,"abstract":"Objective: Tuberculosis (TB) is a significant public health problem that remains important worldwide. This study aimed to examine \u0000the demographic characteristics and clinical features of patients with extrapulmonary tuberculosis (EPTB) and also identify the \u0000comorbidities of EPTB. Our secondary aim was to compare tuberculous lymphadenitis (TBL) with other forms of EPTB. \u0000Patients and Methods: This single-center, retrospective, observational study was conducted on patients diagnosed with EPTB in a \u0000training hospital in Turkey between January 1, 2011 and December 31, 2020. The demographic characteristics and clinical features of \u0000the patients were examined. TBL cases were compared with other forms of EPTB cases. \u0000Results: The most common clinical form was TBL. Fever, night sweats, and accelerated erythrocyte sedimentation rate were \u0000significantly more common in the other forms of the EPTB group compared to TBL. The rate of tuberculin skin test positivity was \u0000significantly higher in patients with TBL. The complication rate was 3%, and mortality rate was 4% among all patients. \u0000Conclusions: Extrapulmonary tuberculosis should be considered in the differential diagnosis by evaluating the medical history of \u0000patients who present with organ-specific symptoms, especially in TB endemic countries. The clinic may differ according to the organ \u0000involvement. TBL may be seen with milder symptoms compared to other clinical forms.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41292900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurdan Senturk Durmus, Furkan C Çiçek, Cagla Eyupler, Can Omur, Ozge Yetginoglu, K. Ak, D. Kocakaya
Thrombosis due to hypercoagulable state is an important cause of morbidity and mortality in coronavirus disease 2019 (COVID-19). . Increased D-dimer levels are an important marker of the presence and risk of thrombosis. In this report, we present that a 59-yearold male patient developed thrombosis in the distal radial arteries despite normal D-dimer level. The patient was treated with enoxaparin, iloprost infusion, and cilostazol. This
{"title":"Radial arterial thrombosis in COVID-19: A case report","authors":"Nurdan Senturk Durmus, Furkan C Çiçek, Cagla Eyupler, Can Omur, Ozge Yetginoglu, K. Ak, D. Kocakaya","doi":"10.5472/marumj.1191199","DOIUrl":"https://doi.org/10.5472/marumj.1191199","url":null,"abstract":"Thrombosis due to hypercoagulable state is an important cause of morbidity and mortality in coronavirus disease 2019 (COVID-19). \u0000. Increased D-dimer levels are an important marker of the presence and risk of thrombosis. In this report, we present that a 59-yearold \u0000male patient developed thrombosis in the distal radial arteries despite normal D-dimer level. The patient was treated with \u0000enoxaparin, iloprost infusion, and cilostazol. This","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45555651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Yavuz, A. T. Toksoz Yildirim, Feruze Yilmaz Enc, I. Tuncer
Parvovirus B19 infection is usually self-limiting in immunocompetent individuals. Twenty-five percent of infected individuals are completely asymptomatic during infection, with 50% of them presenting flu-like symptoms and the remaining patients presenting erythema infectiosum, arthralgia, or arthritis. More rarely, transient aplastic crisis is seen in individuals with chronic haemolytic disorders. Chronic pure red cell aplasia and aplastic anaemia may also be observed in immunocompromised patients. There is sufficient evidence in the literature suggesting that B19 infections can also cause a spectrum of liver diseases, ranging from elevated transaminase levels to acute hepatitis, fulminant liver failure, and even chronic hepatitis. This case report discusses a patient with acute parvovirus infection and newly diagnosed autoimmune hepatitis (AIH) and the role of this viral infection in the disease.
{"title":"Parvovirus-induced autoimmune hepatitis: First case in the literature","authors":"A. Yavuz, A. T. Toksoz Yildirim, Feruze Yilmaz Enc, I. Tuncer","doi":"10.5472/marumj.1195421","DOIUrl":"https://doi.org/10.5472/marumj.1195421","url":null,"abstract":"Parvovirus B19 infection is usually self-limiting in immunocompetent individuals. Twenty-five percent of infected individuals are \u0000completely asymptomatic during infection, with 50% of them presenting flu-like symptoms and the remaining patients presenting \u0000erythema infectiosum, arthralgia, or arthritis. More rarely, transient aplastic crisis is seen in individuals with chronic haemolytic \u0000disorders. Chronic pure red cell aplasia and aplastic anaemia may also be observed in immunocompromised patients. There is \u0000sufficient evidence in the literature suggesting that B19 infections can also cause a spectrum of liver diseases, ranging from elevated \u0000transaminase levels to acute hepatitis, fulminant liver failure, and even chronic hepatitis. This case report discusses a patient with \u0000acute parvovirus infection and newly diagnosed autoimmune hepatitis (AIH) and the role of this viral infection in the disease.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41676232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Balta, M. Kuzucuoğlu, Figen Aslan, Ali Cem Yekdeş
Objective: This study aims to evaluate the efficiencies and effects of different sclerosing agents. Materials and Methods: Thirty-five female Wistar-albino rats were included in this study and divided into five groups randomly. Isotonic saline (group 1), iodopovidone (group 2), rifamycin (group 3), autologous blood (group 4), talc (group 5) were given into intrapleural space. On postoperative 28th day, ipsilateral and contralateral pleural and parenchymal fibrosis and inflammation were evaluated. Results: There were statistically differences between control and other groups on macroscopically pleural fibrosis examination (p=0.004, p=0.001, p=0.001, p=0.000, respectively). Microscopically pleural fibrosis were determined in all groups when compared to control group (p=0.023, p=0.023, p=0.035, p=0.001, respectively). There were no significant differences between sclerosing agent groups (p>0.05). Significant differences were observed according to microscopic pleural inflammation evaluation between talc group and other groups. There was superiority in talc group according to intraparenchymal inflammation grade compared to other groups (p=0.010, p=0.042, p=0.030, respectively). Macroscopically, fibrosis and microscopically, inflammation were significantly observed between talc and other groups in the contralateral pleura (p = 0.037and p=0.009, respectively). Conclusion: Iodopovidone, autologous blood, talc, and rifamycin can be used as effective pleurodesis agents. However, we found that rifamycin and autologous blood are safer as effective pleurodesis agents. We think that these two agents can be used in patients with secondary lung diseases due to their less intraparenchymal inflammation rates. It may be advantageous to prefer other sclerosing agents which has lower costs and less side effects comparing to talc.
{"title":"Evaluation of the efficacy of several sclerosing agents for pleurodesis in rats","authors":"C. Balta, M. Kuzucuoğlu, Figen Aslan, Ali Cem Yekdeş","doi":"10.5472/marumj.1191101","DOIUrl":"https://doi.org/10.5472/marumj.1191101","url":null,"abstract":"Objective: This study aims to evaluate the efficiencies and effects of different sclerosing agents. \u0000Materials and Methods: Thirty-five female Wistar-albino rats were included in this study and divided into five groups randomly. \u0000Isotonic saline (group 1), iodopovidone (group 2), rifamycin (group 3), autologous blood (group 4), talc (group 5) were given into \u0000intrapleural space. On postoperative 28th day, ipsilateral and contralateral pleural and parenchymal fibrosis and inflammation were \u0000evaluated. \u0000Results: There were statistically differences between control and other groups on macroscopically pleural fibrosis examination \u0000(p=0.004, p=0.001, p=0.001, p=0.000, respectively). Microscopically pleural fibrosis were determined in all groups when compared \u0000to control group (p=0.023, p=0.023, p=0.035, p=0.001, respectively). There were no significant differences between sclerosing agent \u0000groups (p>0.05). Significant differences were observed according to microscopic pleural inflammation evaluation between talc group \u0000and other groups. There was superiority in talc group according to intraparenchymal inflammation grade compared to other groups \u0000(p=0.010, p=0.042, p=0.030, respectively). Macroscopically, fibrosis and microscopically, inflammation were significantly observed \u0000between talc and other groups in the contralateral pleura (p = 0.037and p=0.009, respectively). \u0000Conclusion: Iodopovidone, autologous blood, talc, and rifamycin can be used as effective pleurodesis agents. However, we found that \u0000rifamycin and autologous blood are safer as effective pleurodesis agents. We think that these two agents can be used in patients with \u0000secondary lung diseases due to their less intraparenchymal inflammation rates. It may be advantageous to prefer other sclerosing \u0000agents which has lower costs and less side effects comparing to talc.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70885480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study was planned to determine the treatment adherence levels of multiple sclerosis (MS) patients and the factors affecting treatment adherence. Patients and Methods: This descriptive and cross-sectional study was conducted with 211 people with MS. Data for this study was obtained through face-to-face interviews with MS patients who presented at the neurology outpatient clinics of two university hospitals between April and October 2018. The “Morisky, Green, and Levine Adherence Scale”, “Beck Depression Inventory”, “Multidimensional Perceived Social Support Scale”, and the “Illness Perception Scale” were used in data collection. Results: The mean age of the sample was 40.03±10.82, and 70.1% were female. Treatment adherence was not good in half of the patients (51.7%). Patients with good adherence were found to have higher Multidimensional Perceived Social Support Scale scores (p
目的:本研究旨在了解多发性硬化症(MS)患者治疗依从性水平及影响治疗依从性的因素。患者和方法:本研究对211名多发性硬化症患者进行了描述性和横断面研究，本研究的数据是通过对2018年4月至10月在两所大学医院神经内科门诊就诊的多发性硬化症患者进行面对面访谈获得的。数据收集采用Morisky, Green, and Levine依从性量表、Beck抑郁量表、多维感知社会支持量表和疾病感知量表。结果:样本平均年龄为40.03±10.82岁，女性占70.1%。半数患者(51.7%)治疗依从性不佳。依从性好的患者具有更高的多维感知社会支持量表得分(p
{"title":"The effect of social support, depression, and illness perception on treatment adherence in patients with multiple sclerosis","authors":"Derya Gi̇rgi̇n, Z. Tosun, N. Turgut, S. Guler","doi":"10.5472/marumj.1192560","DOIUrl":"https://doi.org/10.5472/marumj.1192560","url":null,"abstract":"Objective: This study was planned to determine the treatment adherence levels of multiple sclerosis (MS) patients and the factors \u0000affecting treatment adherence. \u0000Patients and Methods: This descriptive and cross-sectional study was conducted with 211 people with MS. Data for this study was \u0000obtained through face-to-face interviews with MS patients who presented at the neurology outpatient clinics of two university \u0000hospitals between April and October 2018. The “Morisky, Green, and Levine Adherence Scale”, “Beck Depression Inventory”, \u0000“Multidimensional Perceived Social Support Scale”, and the “Illness Perception Scale” were used in data collection. \u0000Results: The mean age of the sample was 40.03±10.82, and 70.1% were female. Treatment adherence was not good in half of the \u0000patients (51.7%). Patients with good adherence were found to have higher Multidimensional Perceived Social Support Scale scores \u0000(p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43295268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: A significant proportion of patients with seborrheic dermatitis state that disease attacks are triggered by psychological stress and disease severity increases during stressful times. This study aimed to determine the relationship between disease severity and perceived stress and depression levels in patients with seborrheic dermatitis. Patients and Methods: The patients’ demographic characteristics, medical history, and Seborrheic Dermatitis Area Severity Index (SDASI), Perceived Stress Scale (PSS), and Beck Depression Inventory (BDI) scores were recorded, and the relationship between disease severity and the scale scores were statistically analyzed by comparing disease severity groups and using correlation analyses. Results: The study included 120 patients with seborrheic dermatitis. The mean age of the patients was 29.5±8.2 years, and the female/ male ratio was 49/71. According to disease severity, 66 (55%) patients were classified as mild, 30(25%) moderate, and 24 (20%) as severe seborrheic dermatitis. When the scale scores were evaluated, a significant positive correlation was found between SDASI and PSS (r=0.767, p
{"title":"Relationship between disease severity, perceived stress, and depression in patients with seborrheic dermatitis","authors":"Esra Saraç","doi":"10.5472/marumj.1195298","DOIUrl":"https://doi.org/10.5472/marumj.1195298","url":null,"abstract":"Objective: A significant proportion of patients with seborrheic dermatitis state that disease attacks are triggered by psychological \u0000stress and disease severity increases during stressful times. This study aimed to determine the relationship between disease severity \u0000and perceived stress and depression levels in patients with seborrheic dermatitis. \u0000Patients and Methods: The patients’ demographic characteristics, medical history, and Seborrheic Dermatitis Area Severity Index \u0000(SDASI), Perceived Stress Scale (PSS), and Beck Depression Inventory (BDI) scores were recorded, and the relationship between \u0000disease severity and the scale scores were statistically analyzed by comparing disease severity groups and using correlation analyses. \u0000Results: The study included 120 patients with seborrheic dermatitis. The mean age of the patients was 29.5±8.2 years, and the female/ \u0000male ratio was 49/71. According to disease severity, 66 (55%) patients were classified as mild, 30(25%) moderate, and 24 (20%) as \u0000severe seborrheic dermatitis. When the scale scores were evaluated, a significant positive correlation was found between SDASI and \u0000PSS (r=0.767, p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49643914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayse Nilhan Aksu, T. Bilgiç, C. Kayhan, Zumrut Mine Isik Saglam, N. Caf
Objective: St. John’s wort (SJW) oil (Hypericum perforatum) has been used for its immunomodulatory and anti-inflammatory effects. Several studies have shown the efficacy of SJW on wound healing. The aim of this study is to assess the effectiveness of SJW using a combination of biochemical, histopathological and laser Doppler evaluations. Materials and Methods: Sixteen young Wistar albino rats were used as case and control groups (having 8 in each group). After anesthesia protocol, 6 mm punch biopsy was taken from six separate sites on the rats’ dorsal skin. Three wounds were stitched (closed wounds); three wounds were left as they were (open wounds). SJW oil was administered topically to case group once a day for 14 days. Controls did not receive any treatment. Results: There was no statistical difference in blood perfusion between the groups. No statistical difference was present between the groups in GPx (glutathione peroxidase)values. Rat MDA (malonyldialdehyde) values were higher in the case group compared to the control group. SJW oil was found to be beneficial and effective within some histological parameters. Conclusion: SJW may be an effective salve within some parameters. Nevertheless, this judgment is uncertain due to the low sample size. We encourage further studies on this promising natural medicine.
{"title":"Partial healing effects of St. John’s wort oil on the rat excisional wound model","authors":"Ayse Nilhan Aksu, T. Bilgiç, C. Kayhan, Zumrut Mine Isik Saglam, N. Caf","doi":"10.5472/marumj.1186858","DOIUrl":"https://doi.org/10.5472/marumj.1186858","url":null,"abstract":"Objective: St. John’s wort (SJW) oil (Hypericum perforatum) has been used for its immunomodulatory and anti-inflammatory effects. \u0000Several studies have shown the efficacy of SJW on wound healing. The aim of this study is to assess the effectiveness of SJW using a \u0000combination of biochemical, histopathological and laser Doppler evaluations. \u0000Materials and Methods: Sixteen young Wistar albino rats were used as case and control groups (having 8 in each group). After \u0000anesthesia protocol, 6 mm punch biopsy was taken from six separate sites on the rats’ dorsal skin. Three wounds were stitched (closed \u0000wounds); three wounds were left as they were (open wounds). SJW oil was administered topically to case group once a day for 14 days. \u0000Controls did not receive any treatment. \u0000Results: There was no statistical difference in blood perfusion between the groups. No statistical difference was present between the \u0000groups in GPx (glutathione peroxidase)values. Rat MDA (malonyldialdehyde) values were higher in the case group compared to the \u0000control group. SJW oil was found to be beneficial and effective within some histological parameters. \u0000Conclusion: SJW may be an effective salve within some parameters. Nevertheless, this judgment is uncertain due to the low sample \u0000size. We encourage further studies on this promising natural medicine.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45702202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Delen, U. Kasapoğlu, Abdullah Gok, O. Cagasar, B. Tetik, E. Oksuz
Objective: In coronavirus disease – 19 (COVID-19) patients, cytokine storm develops due to the increase of pro-inflammatory cytokines. Tocilizumab (TCZ), has been used in the treatment of COVID-19 patients and successful results have been obtained. The aim of this study was to determine the efficacy of TCZ and also investigate the prognostic factors affecting the success of treatment and mortality in COVID-19 patients treated with TCZ. Patients and Methods: Between March 2020 and August 2021, a total of 326 confirmed severe COVID-19 pneumonia patients, treated in the intensive care unit, were included in the study. Results: The mean age of the patients was 63.02±11.58 years, and 203 (62.3%) of the patients were male. Patients treated with TCZ therapy had a longer survival time compared with the standard therapy (p=0.012). It was found that type of respiratory support (HR:2.19, CI:1.10-4.36, p=0.025) and hyperlactatemia on the day of TCZ therapy admission (HR:2.93 CI:1.53-5.64, p=0.001) were the significant and independent prognostic factors of survival in severe COVID-19 pneumonia patients treated with TCZ. Conclusion: Tocilizumab therapy improved 30-days survival in critically ill COVID-19 pneumonia patients. Also, among the patients treated with TCZ, types of respiratory support and hyperlactatemia on the day of TCZ admission were the independent prognostic factors.
{"title":"Efficacy of tocilizumab therapy in severe COVID-19 pneumonia patients and determination of the prognostic factors affecting 30 days mortality","authors":"L. Delen, U. Kasapoğlu, Abdullah Gok, O. Cagasar, B. Tetik, E. Oksuz","doi":"10.5472/marumj.1191126","DOIUrl":"https://doi.org/10.5472/marumj.1191126","url":null,"abstract":"Objective: In coronavirus disease – 19 (COVID-19) patients, cytokine storm develops due to the increase of pro-inflammatory \u0000cytokines. Tocilizumab (TCZ), has been used in the treatment of COVID-19 patients and successful results have been obtained. The \u0000aim of this study was to determine the efficacy of TCZ and also investigate the prognostic factors affecting the success of treatment \u0000and mortality in COVID-19 patients treated with TCZ. \u0000Patients and Methods: Between March 2020 and August 2021, a total of 326 confirmed severe COVID-19 pneumonia patients, treated \u0000in the intensive care unit, were included in the study. \u0000Results: The mean age of the patients was 63.02±11.58 years, and 203 (62.3%) of the patients were male. Patients treated with TCZ \u0000therapy had a longer survival time compared with the standard therapy (p=0.012). It was found that type of respiratory support \u0000(HR:2.19, CI:1.10-4.36, p=0.025) and hyperlactatemia on the day of TCZ therapy admission (HR:2.93 CI:1.53-5.64, p=0.001) were the \u0000significant and independent prognostic factors of survival in severe COVID-19 pneumonia patients treated with TCZ. \u0000Conclusion: Tocilizumab therapy improved 30-days survival in critically ill COVID-19 pneumonia patients. Also, among the patients \u0000treated with TCZ, types of respiratory support and hyperlactatemia on the day of TCZ admission were the independent prognostic \u0000factors.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48643577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hasan Demir, Aykut Ozkan, Melis Efeoglu Sacak, Nurseli Bayram, Boran ISIN UNAL, Cansu Tiris, Murat Gol, A. Denizbasi
Envenomous viper snakes are not natural inhabitants of Istanbul, Turkey. The city is crowded and lacks an appropriate area for wild life. Viper snakes are mostly found in southern and middle rural Anatolia in Turkey. To our knowledge, viper bites have not been reported in our urban area previously. Here, we report a envenomous snakebite case, treated with polyvalent antivenom successfully. The snake was identified as Vipera Pontica, by the National Poisons Center.
{"title":"A Viper bite in an urban area : A case report","authors":"Hasan Demir, Aykut Ozkan, Melis Efeoglu Sacak, Nurseli Bayram, Boran ISIN UNAL, Cansu Tiris, Murat Gol, A. Denizbasi","doi":"10.5472/marumj.1191161","DOIUrl":"https://doi.org/10.5472/marumj.1191161","url":null,"abstract":"Envenomous viper snakes are not natural inhabitants of Istanbul, Turkey. The city is crowded and lacks an appropriate area for wild \u0000life. Viper snakes are mostly found in southern and middle rural Anatolia in Turkey. To our knowledge, viper bites have not been \u0000reported in our urban area previously. Here, we report a envenomous snakebite case, treated with polyvalent antivenom successfully. \u0000The snake was identified as Vipera Pontica, by the National Poisons Center.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44402937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To examine the number of cases filed about Down syndrome in terms of its numbers, causes and consequences, to provide an overview of what doctors should pay attention to when informing and consulting patients and during follow-up and recommend solutions for decreasing the number of malpractice cases. (Discussing the legal aspect of the decisions is beyond the scope of this research.) Materials and Methods: ‘Down’, ‘Down sendromu’ ‘Down’s, ‘trizomi 21 ‘, ‘trisomi 21’ and ‘trisomy 21’ was written to ‘ https:// karararama.yargitay.gov.tr/ ‘ and ‘https://karararama.danistay.gov.tr/’ web addresses search engines and the data was examined with Microsoft Excel or with R version 4.0.5 ( 2021-03-31) for bias and frequency table was used and the results were examined. Results: A total of 53 cases were found. 49 supreme court and 4 Council of State court decisions are found. The cases are from 27.10.2009 to 13.10.2021.. Conclusion: A total of 39 different Down syndrome cases were examined, as 6 of the 53 cases were related to the same cases and 8 of them were cases not related to Down syndrome. 28 cases are “doctor negligence”, 5 are “reckless killing”, 1 “material mixing in the genetic center”, 1 “unauthorized use of the child’s photo”, 1 “stealing money from the child”, 1 “intentionally injuring the child”, 1 ‘inheritance request for the child’ and 1 on ‘guardianship’.
目的:了解唐氏综合征的发病数量、发病原因及后果，总结医生在告知、咨询患者及随访过程中应注意的问题，为减少唐氏综合征的医疗事故提供对策建议。(讨论这些决定的法律方面超出了本研究的范围。)材料与方法:将“Down”、“Down sendromu”、“Down’s”、“trizomi 21”、“trisomi 21”和“trisomy 21”分别写至https:// karararama.yargitay.gov.tr/”和“https://karararama.danistay.gov.tr/”网址搜索引擎，使用Microsoft Excel或R version 4.0.5(2021-03-31)对数据进行偏差检查，并使用频率表对结果进行检验。结果:共发现53例。发现了49个最高法院和4个国务委员会法院的判决。病例发生时间为2009年10月27日至2021年10月13日。结论:共检查了39例不同的唐氏综合征病例，53例中有6例与同一病例有关，8例与唐氏综合征无关。其中“医生过失”案件28起，“鲁莽杀人”案件5起，“基因中心混料”案件1起，“擅自使用儿童照片”案件1起，“盗窃儿童财物”案件1起，“故意伤害儿童”案件1起，“为儿童请求遗产”案件1起，“监护”案件1起。
{"title":"Investigation of the lawsuits regarding down syndrome","authors":"H. Kaymakçalan","doi":"10.5472/marumj.1186743","DOIUrl":"https://doi.org/10.5472/marumj.1186743","url":null,"abstract":"Objective: To examine the number of cases filed about Down syndrome in terms of its numbers, causes and consequences, to provide \u0000an overview of what doctors should pay attention to when informing and consulting patients and during follow-up and recommend \u0000solutions for decreasing the number of malpractice cases. (Discussing the legal aspect of the decisions is beyond the scope of this \u0000research.) \u0000Materials and Methods: ‘Down’, ‘Down sendromu’ ‘Down’s, ‘trizomi 21 ‘, ‘trisomi 21’ and ‘trisomy 21’ was written to ‘ https:// \u0000karararama.yargitay.gov.tr/ ‘ and ‘https://karararama.danistay.gov.tr/’ web addresses search engines and the data was examined with \u0000Microsoft Excel or with R version 4.0.5 ( 2021-03-31) for bias and frequency table was used and the results were examined. \u0000Results: A total of 53 cases were found. 49 supreme court and 4 Council of State court decisions are found. The cases are from \u000027.10.2009 to 13.10.2021.. \u0000Conclusion: A total of 39 different Down syndrome cases were examined, as 6 of the 53 cases were related to the same cases and 8 \u0000of them were cases not related to Down syndrome. 28 cases are “doctor negligence”, 5 are “reckless killing”, 1 “material mixing in the \u0000genetic center”, 1 “unauthorized use of the child’s photo”, 1 “stealing money from the child”, 1 “intentionally injuring the child”, 1 \u0000‘inheritance request for the child’ and 1 on ‘guardianship’.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42031558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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