Ş. Olgun Yıldızeli, Aslı Tufan Çinçin, H. Arıkan, E. Eryuksel
Objective: A great deal of social support is often provided by the caregiver of the patient. The purpose of this study is to evaluate the burden, fatigue and depression of the primary caregiver of patients with pulmonary transplantation candidates. Patients and Method: The primary caregivers of patients who were admitted to our hospital’s pulmonary transplant outpatient clinic with end-stage pulmonary disease and no definite contraindications for transplantation, were included in the study. Zarit Burden Scale, Beck Depression Inventory and Short-Form (SF)-36 – Vitality questionnaires were applied to participants. Results: Thirty-nine patients and their caregivers were evaluated. Caregivers experienced low levels of depression. Mean score for Beck Depression Inventory was 12.7±10.1. Caregivers generally experienced medium levels of burden. Mean score for Zarit Burden Scale was 26.9±14.2. Majority of caregivers experienced clinically significant fatigue. Mean score for SF-36 – Vitality was 61±16.7. Zarit Burden Scale scores and Beck Depression Inventory scores showed a statistically significant positive correlation (r:0.962 p
{"title":"Burden, depression and fatigue in caregivers of lung transplantation candidates","authors":"Ş. Olgun Yıldızeli, Aslı Tufan Çinçin, H. Arıkan, E. Eryuksel","doi":"10.5472/marumj.1244390","DOIUrl":"https://doi.org/10.5472/marumj.1244390","url":null,"abstract":"Objective: A great deal of social support is often provided by the caregiver of the patient. The purpose of this study is to evaluate the \u0000burden, fatigue and depression of the primary caregiver of patients with pulmonary transplantation candidates. \u0000Patients and Method: The primary caregivers of patients who were admitted to our hospital’s pulmonary transplant outpatient clinic \u0000with end-stage pulmonary disease and no definite contraindications for transplantation, were included in the study. Zarit Burden \u0000Scale, Beck Depression Inventory and Short-Form (SF)-36 – Vitality questionnaires were applied to participants. \u0000Results: Thirty-nine patients and their caregivers were evaluated. Caregivers experienced low levels of depression. Mean score for \u0000Beck Depression Inventory was 12.7±10.1. Caregivers generally experienced medium levels of burden. Mean score for Zarit Burden \u0000Scale was 26.9±14.2. Majority of caregivers experienced clinically significant fatigue. Mean score for SF-36 – Vitality was 61±16.7. \u0000Zarit Burden Scale scores and Beck Depression Inventory scores showed a statistically significant positive correlation (r:0.962 p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44287207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nagehan OZYILMAZ YAY, Nurdan BULBUL AYCI, Rumeysa KELES KAYA, A. Şen, G. Şener, F. Ercan
Objective: The purpose of this study was to examine the protective effects of Myrtus communis L. (MC) extract on high fat-diet (HFD) induced heart and aorta damage by evaluating oxidative stress and the endothelial nitric oxide system (eNOS). Materials and Methods: Wistar albino male rats were divided into 3 groups (n=7) as control, HFD, and HFD+MC. Rats in HFD and HFD+MC groups were HFD fed for 16 weeks and in the last 4 weeks saline or MC (100 mg/kg) was administered orally (5 days/week). Triglyceride, cholesterol, and high-density lipoprotein (HDL) were estimated in blood serum. Tissue oxidative stress and inflammatory parameters were evaluated biochemically. Tissue morphologies, eNOS, inducible NOS (iNOS), and NADPH oxidase-2 (NOX-2)-immunopositive and apoptotic cells were evaluated histologically. Results: Altered serum lipid profiles, degenerated heart, and aorta morphology, increased malondialdehyde, 8‐hydroxy‐2‐ deoxyguanosine, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and myeloperoxidase levels, and iNOS, NOX-2 immunopositive and apoptotic cells, decreased NO levels, eNOS-immunopositive cells in both tissues were observed in HFD group. All these parameters improved in the HFD+MC group. Conclusion: This study revealed that HFD-induced obesity increased iNOS activation and oxidative stress in the cardiac and aortic tissues of the rats. MC improved oxidant/antioxidant balance and prevented heart and aorta damage via eNOS involvement.
{"title":"Morphological and biochemical evaluation of effects of Myrtus communis L. extract on heart and aorta in high fat-diet-induced obese rats","authors":"Nagehan OZYILMAZ YAY, Nurdan BULBUL AYCI, Rumeysa KELES KAYA, A. Şen, G. Şener, F. Ercan","doi":"10.5472/marumj.1302544","DOIUrl":"https://doi.org/10.5472/marumj.1302544","url":null,"abstract":"Objective: The purpose of this study was to examine the protective effects of Myrtus communis L. (MC) extract on high fat-diet (HFD)\u0000induced heart and aorta damage by evaluating oxidative stress and the endothelial nitric oxide system (eNOS).\u0000Materials and Methods: Wistar albino male rats were divided into 3 groups (n=7) as control, HFD, and HFD+MC. Rats in HFD\u0000and HFD+MC groups were HFD fed for 16 weeks and in the last 4 weeks saline or MC (100 mg/kg) was administered orally (5\u0000days/week). Triglyceride, cholesterol, and high-density lipoprotein (HDL) were estimated in blood serum. Tissue oxidative stress and\u0000inflammatory parameters were evaluated biochemically. Tissue morphologies, eNOS, inducible NOS (iNOS), and NADPH oxidase-2\u0000(NOX-2)-immunopositive and apoptotic cells were evaluated histologically.\u0000Results: Altered serum lipid profiles, degenerated heart, and aorta morphology, increased malondialdehyde, 8‐hydroxy‐2‐\u0000deoxyguanosine, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and myeloperoxidase levels, and iNOS, NOX-2\u0000immunopositive and apoptotic cells, decreased NO levels, eNOS-immunopositive cells in both tissues were observed in HFD group.\u0000All these parameters improved in the HFD+MC group.\u0000Conclusion: This study revealed that HFD-induced obesity increased iNOS activation and oxidative stress in the cardiac and aortic\u0000tissues of the rats. MC improved oxidant/antioxidant balance and prevented heart and aorta damage via eNOS involvement.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49028893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emel Kandaş, M. Edremitlioğlu, U. Demir, G. Erbil, M. H. Sehitoglu
Objective: The purpose of this study is to examine the effects of L-carnitine on healing of experimental colon anastomosis injury in early and late period. Materials and Methods: Forty female Wistar-Albino rats were used in this study. The rats were divided into 4 groups (CONT-3, CONT- 7, CARN-3, and CARN-7). Injury healing was evaluated for CONT-3 group on the 3rd day and for CONT-7 group on the 7th day following the anastomosis. Following the operation, CARN-3 and CARN-7 groups were intraperitoneally administered with 100 mg/ kg/day L-carnitine and injury healing was evaluated on the 3rd and 7th days. Injury strength, histological evaluation and antioxidant enzyme activities and oxidant damage were determined in tissue samples of anastomosis area. Results: Bursting pressure levels and histological scoring values of CARN-3 group were found to be higher than the CONT-3 group (p
{"title":"Healing effects of L-carnitine on experimental colon anastomosis wound","authors":"Emel Kandaş, M. Edremitlioğlu, U. Demir, G. Erbil, M. H. Sehitoglu","doi":"10.5472/marumj.1307971","DOIUrl":"https://doi.org/10.5472/marumj.1307971","url":null,"abstract":"Objective: The purpose of this study is to examine the effects of L-carnitine on healing of experimental colon anastomosis injury in \u0000early and late period. \u0000Materials and Methods: Forty female Wistar-Albino rats were used in this study. The rats were divided into 4 groups (CONT-3, CONT- \u00007, CARN-3, and CARN-7). Injury healing was evaluated for CONT-3 group on the 3rd day and for CONT-7 group on the 7th day \u0000following the anastomosis. Following the operation, CARN-3 and CARN-7 groups were intraperitoneally administered with 100 mg/ \u0000kg/day L-carnitine and injury healing was evaluated on the 3rd and 7th days. Injury strength, histological evaluation and antioxidant \u0000enzyme activities and oxidant damage were determined in tissue samples of anastomosis area. \u0000Results: Bursting pressure levels and histological scoring values of CARN-3 group were found to be higher than the CONT-3 group \u0000(p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46348049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kaya, Hakan Hatirli, Muhammed Azad Şahi̇n, Samet Genez, M. Okçu
Objective: To determine the frequency and types of incidental findings on magnetic resonance imaging (MRI) scans of the cervical, thoracic, and lumbar spine in patients with intervertebral discopathy. Patients and Methods: This retrospective study included 1000 patients (513 females and 487 males, with a mean age of 50.5 years) with clinically suspected intervertebral discopathy who underwent MRI. Any abnormal findings and congenital anomalies/anatomical variations unrelated to the primary complaint were referred to as incidental findings. Frequency distributions of the assessed imaging characteristics were calculated. Results: Of the 1000 patients, 192 (19.2%) patients were presented with incidental findings. The positive findings in the thoracic spine (26%) were higher than those in the lumbar (19.8%) and cervical spine (13.7%). The study found vertebral haemangioma to be the most common finding, followed by Schmorl’s nodes in the thoracic and lumbar spine. Thyroid nodules constituted the most common finding in the cervical spine, followed by vertebral haemangioma. Renal cysts in the thoracic and lumbar spine and thyroid nodules in the cervical spine were the most frequent extraspinal findings. Conclusion: Incidental findings are commonly detected during MRI examination of intervertebral discs, and most are benign findings. However, incidental findings including clinically essential findings can alter the patient’s treatment or affect the patient’s life. Therefore, it is crucial to systematically evaluate MRIs without focusing solely on the spine and report incidental findings detected on MRI.
{"title":"Incidental findings detected on magnetic resonance imaging scans of the cervical, thoracic and lumbar spine of patients prediagnosed with discopathy","authors":"S. Kaya, Hakan Hatirli, Muhammed Azad Şahi̇n, Samet Genez, M. Okçu","doi":"10.5472/marumj.1307952","DOIUrl":"https://doi.org/10.5472/marumj.1307952","url":null,"abstract":"Objective: To determine the frequency and types of incidental findings on magnetic resonance imaging (MRI) scans of the cervical, \u0000thoracic, and lumbar spine in patients with intervertebral discopathy. \u0000Patients and Methods: This retrospective study included 1000 patients (513 females and 487 males, with a mean age of 50.5 years) \u0000with clinically suspected intervertebral discopathy who underwent MRI. Any abnormal findings and congenital anomalies/anatomical \u0000variations unrelated to the primary complaint were referred to as incidental findings. Frequency distributions of the assessed imaging \u0000characteristics were calculated. \u0000Results: Of the 1000 patients, 192 (19.2%) patients were presented with incidental findings. The positive findings in the thoracic spine \u0000(26%) were higher than those in the lumbar (19.8%) and cervical spine (13.7%). The study found vertebral haemangioma to be the \u0000most common finding, followed by Schmorl’s nodes in the thoracic and lumbar spine. Thyroid nodules constituted the most common \u0000finding in the cervical spine, followed by vertebral haemangioma. Renal cysts in the thoracic and lumbar spine and thyroid nodules in \u0000the cervical spine were the most frequent extraspinal findings. \u0000Conclusion: Incidental findings are commonly detected during MRI examination of intervertebral discs, and most are benign findings. \u0000However, incidental findings including clinically essential findings can alter the patient’s treatment or affect the patient’s life. Therefore, \u0000it is crucial to systematically evaluate MRIs without focusing solely on the spine and report incidental findings detected on MRI.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41548184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Toptas, Kubra Bercem Kahraman, Zilan Topcu, H. Bostan, P. Kadıoğlu
Objective: Data about the impact of Cushing’s syndrome (CS) on thyroid is scarce. We aimed to identify the prevalence of thyroid diseases in patients with CS. Patients and Methods: Nineteen patients with CS and 40 healthy participants were included in the study. All patients were tested for free tri-iodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), anti-thyroglobulin (anti-Tg), and antithyroid peroxidase (anti-TPO) levels, and thyroid ultrasonography (US). Results: Overt hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism was evident in 5.3%, 5.3%, and 21.1% of patients with CS; and 2.5%, 7.5%, and 15% of healthy subjects, respectively. fT3 and fT4 levels were lower in patients with CS. None of the patients with CS and 27.5% of the control group had autoimmune thyroid disease (AITD), which was demonstrated by both US findings and anti-TPO positivity (P=0.01). Frequency of thyroid nodule was 52.6% and 52.5% in patients with CS and controls, respectively (P=0.99). Conclusion: The prevalence of thyroid dysfunction, nodular thyroid disease, and goiter is comparable to healthy population. However, AITD is less prevalent among patients with CS. Although, hypercortisolism has an impact on hypothalamic-hypophyseal-thyroid axis, its clinical implication does not seem to be significant.
{"title":"Thyroid diseases in patients with active endogenous Cushing’s syndrome","authors":"T. Toptas, Kubra Bercem Kahraman, Zilan Topcu, H. Bostan, P. Kadıoğlu","doi":"10.5472/marumj.1186788","DOIUrl":"https://doi.org/10.5472/marumj.1186788","url":null,"abstract":"Objective: Data about the impact of Cushing’s syndrome (CS) on thyroid is scarce. We aimed to identify the prevalence of thyroid \u0000diseases in patients with CS. \u0000Patients and Methods: Nineteen patients with CS and 40 healthy participants were included in the study. All patients were tested \u0000for free tri-iodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), anti-thyroglobulin (anti-Tg), and antithyroid \u0000peroxidase (anti-TPO) levels, and thyroid ultrasonography (US). \u0000Results: Overt hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism was evident in 5.3%, 5.3%, and 21.1% of \u0000patients with CS; and 2.5%, 7.5%, and 15% of healthy subjects, respectively. fT3 and fT4 levels were lower in patients with CS. None \u0000of the patients with CS and 27.5% of the control group had autoimmune thyroid disease (AITD), which was demonstrated by both \u0000US findings and anti-TPO positivity (P=0.01). Frequency of thyroid nodule was 52.6% and 52.5% in patients with CS and controls, \u0000respectively (P=0.99). \u0000Conclusion: The prevalence of thyroid dysfunction, nodular thyroid disease, and goiter is comparable to healthy population. However, \u0000AITD is less prevalent among patients with CS. Although, hypercortisolism has an impact on hypothalamic-hypophyseal-thyroid \u0000axis, its clinical implication does not seem to be significant.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44868532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Necati Yurdakul, Esra CIKLER1,3, H. Toklu, S. Şirvancı
Objective: In the present study, we aimed to investigate the morphological and biochemical effects of alpha-lipoic acid (ALA) on bladder injury caused by water avoidance stress (WAS) and to show its effect on the number of degranulated mast cells, which increase after stress. Materials and Methods: Wistar albino rats were subjected to WAS and the animals in the treatment group were injected ALA. After the urinary bladder tissues were subjected to routine tissue processing, hematoxylin-eosin staining and periodic acid-Schiff reaction were applied to observe general morphology and acidic toluidine blue method to investigate mast cells. Biochemical assessments of malondialdehyde (MDA) and glutathione (GSH) were also obtained. Transmission electron microscope was used for the ultrastructural, and scanning electron microscope for the topographical analyses. Results: The experiments showed that chronic stress caused injury in the bladder, increased degranulated and total number of mast cells and decreased GSH and increased MDA levels. ALA treatment after WAS ameliorated bladder injury in most areas, decreased degranulated and total mast cell number and increased GSH and decreased MDA levels. Conclusion: It was concluded that ALA can be a useful agent in the treatment of interstitial cystitis.
{"title":"The effects of alpha-lipoic acid (ALA) on the urinary bladder injury in rats exposed to chronic stress: A histochemical study","authors":"Necati Yurdakul, Esra CIKLER1,3, H. Toklu, S. Şirvancı","doi":"10.5472/marumj.1191211","DOIUrl":"https://doi.org/10.5472/marumj.1191211","url":null,"abstract":"Objective: In the present study, we aimed to investigate the morphological and biochemical effects of alpha-lipoic acid (ALA) on \u0000bladder injury caused by water avoidance stress (WAS) and to show its effect on the number of degranulated mast cells, which \u0000increase after stress. \u0000Materials and Methods: Wistar albino rats were subjected to WAS and the animals in the treatment group were injected ALA. After \u0000the urinary bladder tissues were subjected to routine tissue processing, hematoxylin-eosin staining and periodic acid-Schiff reaction \u0000were applied to observe general morphology and acidic toluidine blue method to investigate mast cells. Biochemical assessments \u0000of malondialdehyde (MDA) and glutathione (GSH) were also obtained. Transmission electron microscope was used for the \u0000ultrastructural, and scanning electron microscope for the topographical analyses. \u0000Results: The experiments showed that chronic stress caused injury in the bladder, increased degranulated and total number of mast \u0000cells and decreased GSH and increased MDA levels. ALA treatment after WAS ameliorated bladder injury in most areas, decreased \u0000degranulated and total mast cell number and increased GSH and decreased MDA levels. \u0000Conclusion: It was concluded that ALA can be a useful agent in the treatment of interstitial cystitis.","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45311085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Enlarged pulmonary artery diameter (PAD) can be associated with mortality risk in coronavirus disease 2019 (COVID-19) patients. Our aim is to find the factors that cause changes in PAD and the relationship between radiological findings and clinical outcomes in COVID-19 patients. Patients and Methods: In this descriptive, retrospective, and single centered study, among the hospitalized 3264 patients, 209 patients with previous chest computed tomography (CT) were included. Findings of current chest CTs of patients obtained during COVID-19 were compared with that of previous chest CTs. Pulmonary involvements, World Health Organization (WHO) Clinical Progression Scale scores and laboratory variables were recorded. Intensive Care Unit (ICU) admission, intubation and mortality were clinical outcomes that were evaluated by using uni – and multivariate analyses. Results: Patients with high D-dimer had significantly increased risk for enlarged PAD and increase in PAD compared to previous chest CT (ΔPAD) (OR=1.18, p
目的:2019冠状病毒病(COVID-19)患者肺动脉直径增大与死亡风险相关。我们的目的是发现导致COVID-19患者PAD变化的因素以及影像学表现与临床结局之间的关系。患者和方法:在这项描述性、回顾性、单中心研究中，住院3264例患者中包括209例既往胸部计算机断层扫描(CT)患者。将COVID-19期间获得的患者当前胸部ct结果与既往胸部ct结果进行比较。记录肺部病变、世界卫生组织(WHO)临床进展量表评分和实验室变量。重症监护病房(ICU)入院、插管和死亡率是通过单因素和多因素分析评估的临床结果。结果:与既往胸部CT相比，高d -二聚体患者PAD扩大和PAD增加的风险显著增加(ΔPAD) (OR=1.18, p
{"title":"Association of the changes in pulmonary artery diameters with clinical outcomes in hospitalized patients with COVID-19 infection: A crosssectional study","authors":"Aybuke Selcuk, C. Ilgın, S. Karakurt","doi":"10.5472/marumj.1195539","DOIUrl":"https://doi.org/10.5472/marumj.1195539","url":null,"abstract":"Objective: Enlarged pulmonary artery diameter (PAD) can be associated with mortality risk in coronavirus disease 2019 (COVID-19) patients. Our aim is to find the factors that cause changes in PAD and the relationship between radiological findings and clinical outcomes in COVID-19 patients. Patients and Methods: In this descriptive, retrospective, and single centered study, among the hospitalized 3264 patients, 209 patients with previous chest computed tomography (CT) were included. Findings of current chest CTs of patients obtained during COVID-19 were compared with that of previous chest CTs. Pulmonary involvements, World Health Organization (WHO) Clinical Progression Scale scores and laboratory variables were recorded. Intensive Care Unit (ICU) admission, intubation and mortality were clinical outcomes that were evaluated by using uni – and multivariate analyses. Results: Patients with high D-dimer had significantly increased risk for enlarged PAD and increase in PAD compared to previous chest CT (ΔPAD) (OR=1.18, p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47607373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: We aimed to determine respiratory morbidity of late preterm infants versus infants with intrauterine growth retardation (IUGR) at school-age. Patients and Methods: Late preterm appropriate for gestational age (AGA) infants (34-36, 6/7 weeks) (Group 1), IUGR infants (Group 2), extremely preterm AGA (Group 3) and term AGA infants (Group 4) born between 2004 and 2008 were included in this casecontrol study and assessed for respiratory morbidity at school-age. We evaluated the impact of late preterm compared with IUGR and term gestation on respiratory morbidity by using validated American Thoracic Society – Division of Lung Diseases (ATS-DLD-78-C) and the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires. Questionnaires on wheezing, infectious respiratory morbidity, and physician-diagnosed asthma panels were constituted and groups were compared. Results: A total of 160 patients were enrolled in the study and 97 (60.6%) of them were boys. Respiratory morbidities at schoolage were found to be significantly higher in both late preterm and IUGR groups when compared to term controls. Each weekly increase in gestational age reduced the risk for wheezing episodes (OR perGW:0.82,95%CI:0.71-0.97, p:0.02). Regarding infectious respiratory morbidities, there was a significant increase when the number of people living at home increased (OR perperson:1.79,95%CI:1.12-2.87, p:0.01), and a decrease in female gender (OR:0.41,95%CI:0.17-0.99, p:0.04) and in the week of gestation (OR perGW:0.84,95%CI:0.71-1.00, p:0.04). Atopic dermatitis (OR:5.26,95%CI:1.57-17.69, p
{"title":"Comparison of respiratory morbidity in late preterm infants and intrauterine growth retarded infants at school-age","authors":"M. Us, U. Vatansever, R. Duran, B. Acunaş","doi":"10.5472/marumj.1195309","DOIUrl":"https://doi.org/10.5472/marumj.1195309","url":null,"abstract":"Objective: We aimed to determine respiratory morbidity of late preterm infants versus infants with intrauterine growth retardation \u0000(IUGR) at school-age. \u0000Patients and Methods: Late preterm appropriate for gestational age (AGA) infants (34-36, 6/7 weeks) (Group 1), IUGR infants (Group \u00002), extremely preterm AGA (Group 3) and term AGA infants (Group 4) born between 2004 and 2008 were included in this casecontrol \u0000study and assessed for respiratory morbidity at school-age. We evaluated the impact of late preterm compared with IUGR and \u0000term gestation on respiratory morbidity by using validated American Thoracic Society – Division of Lung Diseases (ATS-DLD-78-C) \u0000and the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires. Questionnaires on wheezing, infectious \u0000respiratory morbidity, and physician-diagnosed asthma panels were constituted and groups were compared. \u0000Results: A total of 160 patients were enrolled in the study and 97 (60.6%) of them were boys. Respiratory morbidities at schoolage \u0000were found to be significantly higher in both late preterm and IUGR groups when compared to term controls. Each weekly \u0000increase in gestational age reduced the risk for wheezing episodes (OR perGW:0.82,95%CI:0.71-0.97, p:0.02). Regarding \u0000infectious respiratory morbidities, there was a significant increase when the number of people living at home increased (OR \u0000perperson:1.79,95%CI:1.12-2.87, p:0.01), and a decrease in female gender (OR:0.41,95%CI:0.17-0.99, p:0.04) and in the week of \u0000gestation (OR perGW:0.84,95%CI:0.71-1.00, p:0.04). Atopic dermatitis (OR:5.26,95%CI:1.57-17.69, p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47058368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the short – and long-term dynamics in inflammation markers [systemic immune-inflammation index (SII), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/ monocyte ratio (LMR)] before and after biological disease-modifying antirheumatic drugs (bDMARD) or targeted synthetic DMARD (tsDMARD) treatment. Patients and Methods: wo hundred twenty-six patients (115 women, 47±13.8 years) were included. Age, gender, disease duration, and treatments were recorded retrospectively. Complete blood counts including neutrophil, lymphocyte, platelet, monocyte and acute phase reactants were noted at the visit before the biological treatment, at the 3rd month, 6th month, and the last visit on medication. SII, NLR, PLR and LMR were calculated, and their dynamics over time were compared. Results: Significant changes were observed over time in all parameters reflecting inflammation (SII, NLR, PLR, LMR, ESR, and CRP) (p
{"title":"Systemic immune-inflammation index and other inflammatory parameters in patients receiving biological or targeted synthetic DMARDs for inflammatory rheumatic disease","authors":"H. H. Gezer, O. Pehlivan","doi":"10.5472/marumj.1186732","DOIUrl":"https://doi.org/10.5472/marumj.1186732","url":null,"abstract":"Objective: To investigate the short – and long-term dynamics in inflammation markers [systemic immune-inflammation index (SII), \u0000neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/ monocyte ratio (LMR)] before and after \u0000biological disease-modifying antirheumatic drugs (bDMARD) or targeted synthetic DMARD (tsDMARD) treatment. \u0000Patients and Methods: wo hundred twenty-six patients (115 women, 47±13.8 years) were included. Age, gender, disease duration, and \u0000treatments were recorded retrospectively. Complete blood counts including neutrophil, lymphocyte, platelet, monocyte and acute \u0000phase reactants were noted at the visit before the biological treatment, at the 3rd month, 6th month, and the last visit on medication. \u0000SII, NLR, PLR and LMR were calculated, and their dynamics over time were compared. \u0000Results: Significant changes were observed over time in all parameters reflecting inflammation (SII, NLR, PLR, LMR, ESR, and CRP) \u0000(p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41366289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kardelen Gençer Atalay, Merve Demirci, Ozgur Baysal, Canan Şanal Toprak
Objective: This study aimed to examine the factors affecting the loss of workforce, including the time to return to work and workrelated situations in patients with traumatic hand injury who were taken to a hand rehabilitation program. Materials and Methods: The patients aged between 18-65 years with a history of traumatic hand injury in the last five years were analyzed retrospectively. Demographic and clinic data were taken from the medical records, and work-related problems were obtained by telephone calls. The severity of hand injury was assessed with Modified Hand Injury Severity Score (MHISS). Results: A total of 147 patients (129 males, 18 females; mean age 39.83±10.4 years) were included. The duration of return to work was correlated with total MHISS (rho=0.262 p=0.003) while not related to age, education level, gender, or injured hand’s dominance (p>0.05). Duration of return to work after hand injury and total MHISS were lower in the patients who had job modifications (p
{"title":"Assessment of the factors affecting the loss of workforce in patients with traumatic hand injury","authors":"Kardelen Gençer Atalay, Merve Demirci, Ozgur Baysal, Canan Şanal Toprak","doi":"10.5472/marumj.1186710","DOIUrl":"https://doi.org/10.5472/marumj.1186710","url":null,"abstract":"Objective: This study aimed to examine the factors affecting the loss of workforce, including the time to return to work and workrelated \u0000situations in patients with traumatic hand injury who were taken to a hand rehabilitation program. \u0000Materials and Methods: The patients aged between 18-65 years with a history of traumatic hand injury in the last five years were \u0000analyzed retrospectively. Demographic and clinic data were taken from the medical records, and work-related problems were obtained \u0000by telephone calls. The severity of hand injury was assessed with Modified Hand Injury Severity Score (MHISS). \u0000Results: A total of 147 patients (129 males, 18 females; mean age 39.83±10.4 years) were included. The duration of return to work \u0000was correlated with total MHISS (rho=0.262 p=0.003) while not related to age, education level, gender, or injured hand’s dominance \u0000(p>0.05). Duration of return to work after hand injury and total MHISS were lower in the patients who had job modifications \u0000(p","PeriodicalId":43341,"journal":{"name":"Marmara Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49421954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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