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Depression, Anxiety, Psychosomatic Symptoms, and Perceived Social Support in Type D and Non-type D Individuals D型和非D型个体的抑郁、焦虑、心身症状和感知社会支持
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-04-10 DOI: 10.32598/IJPCP.27.1.3479.1
U. Kalsoom, Bibi Hanifa
Objectives: This study examines depression, anxiety, psychosomatic symptoms, and perceived social support among type D and non-type D individuals. Methods: A total of 300 individuals aged 18 to 40 years were recruited in the investigation. We used the distress personality scale (DS 14), Pakistan anxiety and despondency scale, psychosomatic symptoms, and perceived social support scales to obtain the study data. The study participants were divided into Type D (n=166) and non-Type D individuals (n=134) based on their DS 14 cut-off scores. In this descriptive study, a random cluster sampling technique was utilized to choose the samples. The study was conducted from September to December 2017. Data analysis was performed utilizing independent samples t-test and regression analysis. Results: The recurrence of the Type D personality was 55%. Results indicated a considerable difference between Type D and non-Type D personality on depression, anxiety, and psychosomatic side effects (P < 0.001 for all side effects). The findings also suggest that Type D individuals perceived less social support from family, friends, and significant others. Conclusion: People with type D character qualities show more depression, anxiety, psychosomatic symptoms, and less perceived social support when compared with non-Type D people.
目的:本研究调查了D型和非D型个体的抑郁、焦虑、心身症状和感知社会支持。方法:共招募300名年龄在18至40岁之间的个体进行调查。我们使用了痛苦人格量表(DS-14)、巴基斯坦焦虑和抑郁量表、心身症状和感知社会支持量表来获得研究数据。研究参与者根据他们的DS 14截止分数被分为D型(n=166)和非D型个体(n=134)。在这项描述性研究中,采用了随机整群抽样技术来选择样本。该研究于2017年9月至12月进行。数据分析采用独立样本t检验和回归分析。结果:D型人格的复发率为55%。结果表明,D型人格和非D型人格在抑郁、焦虑和心身副作用方面存在显著差异(所有副作用均<0.001)。研究结果还表明,D型个体感知到来自家人、朋友和重要他人的社会支持较少。结论:与非D型人群相比,具有D型性格特征的人表现出更多的抑郁、焦虑、心身症状,以及更少的社会支持感。
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引用次数: 1
Comparison of the Childhood Trauma, Mindfulness Attention Awareness and Integrative Self Knowledge in Cancer Patients and General Population 癌症患者与普通人群童年创伤、正念、注意意识和综合自我认知的比较研究
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-04-10 DOI: 10.32598/IJPCP.27.1.3187.1
M. Khanjani, Shadan Mosavat, Bahman Bbahmani, E. Bakhshi
Objectives: This study aims to compare childhood trauma, integrative self-knowledge and mindfulness in patients with cancer and healthy people. Methods: This descriptive-analytical study was conducted on 139 patients with cancer and 139 healthy people referred to Firoozgar Hospital and SAMAR Charity House who were selected by a convenience sampling method. They were asked to complete Integrative Self-Knowledge (ISK) Questionnaire, Childhood Trauma Questionnaire (CTQ) and Mindfulness Attention Awareness Scale (MAAS). Data were analyzed using descriptive and inferential statistic methods including MANOVA. Results: There was a significant difference between patients and controls in terms of ISK (P<0.001), mindfulness (P<0.001) and childhood trauma (P<0.001). Conclusion: Cancer patients have lower ISK and mindfulness but higher childhood trauma compared to healthy people. Attention should be paid to the role of these factors in prevention and treatment processes.
目的:本研究旨在比较癌症患者和健康人的童年创伤、综合自我认知和正念。方法:对139例癌症患者和139名在菲鲁兹加医院和SAMAR慈善院就诊的健康人进行描述分析研究。他们被要求完成综合自我知识问卷(ISK)、儿童创伤问卷(CTQ)和正念注意意识量表(MAAS)。数据分析采用描述性和推断性统计方法,包括MANOVA。结果:癌症患者在ISK(P<0.001)、正念(P<0.01)和儿童创伤(P<0.05)方面与对照组相比有显著性差异。应注意这些因素在预防和治疗过程中的作用。
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引用次数: 0
Adaptation and Normalization of the Nomophobia Questionnaire (NMP-Q) to Persian in a Sample of University Students 大学生游牧恐惧症问卷(NMP-Q)对波斯语的适应性和规范化
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.2.3030.1
Mohsen Alizadeh, Ahmad Ashuori, M. Hasani, Gohar Mianbandi
Objective: To validate and normalize the Nomophobia Questionnaire (NMP-Q) for use in Iran. Method: This study was a correlation study. Participants in this study were 280 undergraduate students of Mashhad universities in 95-96 who were selected by multistage cluster sampling and responded into Persian version of Nomophobia Questionnaire (NMP-Q) and the Cell-Phone Over-Use Scale (COS). Forty participants answered the questionnaire again two weeks later to assess the validity of the test-retest. The data were analyzed by SPSS statistical software version 20 and LISREL version 8 software. Cronbachchr('39')s alpha, Pearsonchr('39')s correlation analysis and confirmatory factor analysis were used in this study. Results: The results indicated high validity of the questionnaire (Cronbachchr('39')s alpha for all items was 0.921 and for subscales ranging from 0.748 to 0.885). Concurrent validity was equal to (r = 0.51) and retest validity equal to (r = 0.81). Also confirmatory factor analysis results showed that all four factors of the original questionnaire were confirmed in Persian version. Conclusion: According to the results, the Persian version of the Nomophobia Questionnaire has good validity and validity for use in Iran.
目的:验证和规范在伊朗使用的无恐惧症问卷(NMP-Q)。方法:本研究为相关性研究。本研究采用多阶段整群抽样的方法,选取1995 - 1996年马什哈德大学的280名本科生,填写波斯语版手机恐惧症问卷(NMP-Q)和手机过度使用量表(COS)。40名参与者在两周后再次回答问卷,以评估测试-重测的有效性。采用SPSS统计软件20版和LISREL软件8版对数据进行分析。本研究采用Cronbachchr('39') α、Pearsonchr('39')相关分析和验证性因子分析。结果:问卷具有较高的效度(各条目的Cronbachchr('39') alpha值为0.921,各分量表的α值为0.748 ~ 0.885)。并发效度= (r = 0.51),重测效度= (r = 0.81)。验证性因子分析结果显示,原始问卷的四个因素在波斯语版本中都得到了证实。结论:波斯语版无恐惧症问卷具有较好的效度和在伊朗使用的效度。
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引用次数: 1
The Effect of Computer Games on Improving Working Memory, Visual Memory, and Control of Executive Functions amongst the Elderly in Tehran 电脑游戏对改善德黑兰老年人工作记忆、视觉记忆和执行功能控制的影响
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.2.3401.1
Prosha Moradi, Abas Masjedi Arani, M. Jafari
Introduction & purpose: Cognitive ability decline is among the age-related changes in the elderly. Recent research has shown that computer games has a positive effect on cognitive abilities. Accordingly, the present study aimed at determining the effect of computer games on improving working memory, visual memory, and executive functions amongst the elderly in the city of Tehran. Methodology: The present study had a quasi-experimental pretest-posttest design with the control group that was carried out on 40 elderly people selected using targeted sampling method in Tehran. The participants were randomly assigned to either the experimental or the control group after reviewing the inclusion criteria and clinical interview by the researchers. The experimental group was asked to play a one-hour computer game of Lumosity during 15 sessions and the control group was not allowed to play any computer games during this time. The data were collected in two stages of pre-test and post-test. Finally, the collected data were analyzed using SPSS software, version 25. Findings: Computer games had a significant effect on the improvement of working memory, visual memory, and executive functions amongst the elderly in the experimental group compared to the control group (P<0.05). Discussion and Conclusion: Computer games can be helpful to improve memory and cognitive functions amongst the elderly. Accordingly, it is recommended to use these games in nursing homes for elderly people and the related centers should use these games to rehabilitate the elderly.
简介与目的:认知能力下降是老年人的年龄相关变化之一。最近的研究表明,电脑游戏对认知能力有积极的影响。因此,本研究旨在确定电脑游戏对改善德黑兰市老年人的工作记忆、视觉记忆和执行功能的影响。方法:本研究采用准实验前测后测设计,以德黑兰地区40名老年人为研究对象,采用针对性抽样法进行对照组研究。在研究人员审核纳入标准和临床访谈后,将参与者随机分为实验组和对照组。实验组被要求在15次测试中玩一小时的Lumosity电脑游戏,而对照组在此期间不允许玩任何电脑游戏。数据收集分为前测和后测两个阶段。最后,使用SPSS软件25版对收集到的数据进行分析。研究发现:与对照组相比,电脑游戏对实验组老年人的工作记忆、视觉记忆和执行功能的改善有显著影响(P<0.05)。讨论与结论:电脑游戏有助于提高老年人的记忆力和认知能力。因此,建议在养老院使用这些游戏,相关中心也应该使用这些游戏来进行老年人的康复。
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引用次数: 3
Evaluation of Psychometric Indicators Persian Version of Behavior Assessment System for Children (BASC-3) in Girls And Boys with Mild Intellectually Disabled and Normal Intelligence (PRS-A & TRS-A) Form 波斯版儿童行为评估系统(BASC-3)对轻度智障和正常智力女童和男童(PRS-A和TRS-A)表的心理测量指标评价
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.4.3462.1
L. akrami, M. Malekpour, A. Abedi
Objective: The purpose of the present study was evaluation of psychometric indicators Persian version of Behavior Assessment System for Children (BASC-3) in girls and boys with mild intellectually disabled and normal intelligence in the city of Yazd. Methods: The present study was a cross-sectional study. This study was performed on girls and boys with mild intellectually disabled and normal intelligence in 2016-2017. The research sample consisted of 438 students who were selected by using cluster sampling method. The data collection tools included (BASC-3), Parental form (PRS-A) and teacher form (TRS-A). Data analysis were performed in SPSS v.24 using descriptive and inferential statistics. Results: The results obtained using factor analysis, correlation coefficient of subscales with total score, test-retest and Cronbachchr('39')s alpha showed that (BASC-3) system has appropriate validity and reliability for both groups, and PRS-A & TRS-A form can be used for both groups with mild intellectually disabled and normal intelligence. Conclusion: According to the results of the present study, it can be said that (BASC-3), Parental form (PRS-A) and teacher form (TRS-A), have appropriate psychometric properties and can be used with confidence to evaluate the behavioral and adaptive problems of adolescents and young people with mild intellectually disabled and normal intelligence in Iran.
目的:对亚兹德市轻度智障儿童和正常智力儿童的心理测量指标进行波斯版儿童行为评估系统(BASC-3)测评。方法:本研究为横断面研究。本研究于2016-2017年在轻度智障和正常智力的女孩和男孩中进行。研究样本采用整群抽样法抽取学生438人。数据收集工具包括BASC-3表、家长表(PRS-A)和教师表(TRS-A)。数据分析在SPSS v.24中使用描述性统计和推理统计进行。结果:因子分析、总分量表、重测量表及Cronbachchr('39') alpha相关系数结果表明,(BASC-3)量表对两组均具有适当的效度和信度,轻度智障组和正常智力组均可采用rs - a和TRS-A量表。结论:根据本研究结果,BASC-3量表、家长表(PRS-A)和教师表(TRS-A)具有适当的心理测量性质,可可靠地用于评估伊朗轻度智障和正常智力青少年的行为和适应问题。
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引用次数: 0
Comparison of the Effectiveness of Motivational Manipulation and Neurofeedback Methods on Sensitivity to Reward, Delay Discounting and Impulsivity in Children with Attention Deficit / Hyperactivity Disorder 动机操纵与神经反馈方法对注意缺陷/多动障碍儿童奖励敏感性、延迟折扣和冲动性的影响比较
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.4.3572.1
Siyamak Tahmasebi Garmtani, Alireza Karimpour Vazifehkhorani
Purpose; The aim of this study was to comparison of the effectiveness of two methods of motivational manipulation and neurofeedback on sensitivity to reward, delay discounting and impulsivity in children with attention deficit / hyperactivity disorder. Methods; The present study was an experimental study with pre-test, post-test, follow-up and control group. The study population consisted of children aged 7 to 12 years with ADHD. Available sampling method was used for sampling in this study. Sample size was selected based on the purpose and method of research (in experimental research, the sample size of at least 30 people in each group is recommended) 90 people. In this study, neurofeedback and motivational manipulation were performed on the intervention group as an intervention, each session was performed for 12 sessions and each session was performed for 45 minutes. Balloon risk test and delay discounting test were used to collect data in pre-test, post-test and follow-up stages and the data were analyzed using MANCOVA statistical method in SPSS-23. Results; By controlling the effects of pretest on posttest, the difference between the groups in the posttest was statistically significant between the variables of impulsivity and delay at the level of P <0.01 and between the variables of reward sensitivity at the level of P <0.05. The results also showed that neurofeedback method (M = 4.66) had a greater effect on reward processing than motivational manipulation method (M = 2.31) compared to the control group, which was significant at the level of P <0.01. But the difference between the mean of motivational manipulation (M = 2.31) in comparison with the control group was not significant. Conclusion; Voluntary activation of dopaminergic regions of the brain by neurofeedback and motivational manipulation leads to endogenous dopamine control in these structures, leading to successful regulation or inhibitory control and reduced cravings, which reduces impulsivity, delay discounting, and sensitivity to reward.
目的;本研究的目的是比较动机操纵和神经反馈两种方法对注意缺陷/多动障碍儿童奖励敏感性、延迟折扣和冲动性的影响。方法;本研究为实验研究,分为前测、后测、随访和对照组。研究人群包括7至12岁患有多动症的儿童。本研究采用现有抽样方法进行抽样。样本量根据研究目的和研究方法选择(在实验研究中,建议每组至少30人的样本量)90人。本研究对干预组进行神经反馈和动机操纵作为干预,每组12次,每次45分钟。采用气球风险测试和延迟折现测试收集测试前、测试后和随访阶段的数据,采用SPSS-23中的MANCOVA统计方法对数据进行分析。结果;在控制前测对后测的影响后,冲动性和延迟性变量在P <0.01水平上,奖励敏感性变量在P <0.05水平上,组间后测差异有统计学意义。与对照组相比,神经反馈法(M = 4.66)对奖励加工的影响显著高于动机操纵法(M = 2.31),差异有统计学意义(P <0.01)。但动机操纵的均值(M = 2.31)与对照组比较差异无统计学意义。结论;通过神经反馈和动机操纵,大脑多巴胺能区域的自愿激活导致这些结构中的内源性多巴胺控制,导致成功的调节或抑制控制和减少渴望,从而减少冲动,延迟折扣和对奖励的敏感性。
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引用次数: 0
Inter-Parental Agreement and Discrepancy on ADHD Core Symptoms and Externalizing Problems Among School-Age Children with ADHD 学龄期ADHD儿童ADHD核心症状和外部化问题的父母间一致性和差异性
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.3.3426.1
Ghazaleh Zargarinejad, Saeed Ebadi Zare, B. Gharraee, Asma Aghebati, H. Farahani, E. Shirazi
1. PhD Candidate in Clinical Psychology, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran. 2. PhD in Clinical Psychology, Assistant professor, Department of Clinical Psychology, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran. 3. PhD in Clinical Psychology, Associate professor, Department of Clinical Psychology, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran. 4. PhD in Psychometrics, Assistant professor, Department of Psychology, Tarbiat Modares University, Tehran, Iran. 5. Child and Adolescent psychiatrist, Associate professor, Department of Psychiatry, Spiritual Health Research Center, School of Behavioral Sciences and Mental Health (Tehran Institute of Psychiatry), Iran University of Medical Sciences, Tehran, Iran.
1.伊朗医学科学大学行为科学与心理健康学院(德黑兰精神病学研究所)临床心理学博士生,伊朗德黑兰。2.伊朗医学科学大学行为科学与心理健康学院(德黑兰精神病学研究所)临床心理学博士,临床心理学系助理教授,伊朗德黑兰。3.伊朗医学科学大学行为科学与心理健康学院(德黑兰精神病学研究所)临床心理学博士,临床心理学系副教授,伊朗德黑兰。4.心理计量学博士,伊朗德黑兰Tarbiat Modares大学心理学系助理教授。5.儿童和青少年精神病学家,伊朗德黑兰医学科学大学行为科学与心理健康学院(德黑兰精神病学研究所)精神健康研究中心精神病学系副教授。
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引用次数: 1
Comparison of the Effectiveness of Integrated Cognitive-Behavioral Therapy with Transdiagnostic Treatment on Symptoms of Patients with Generalized Anxiety Disorder Comorbid with Depression 认知行为综合治疗与跨诊断治疗对广泛性焦虑障碍伴抑郁症状的疗效比较
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.4.3067.3
F. Ghaderi, N. Akrami, Koroosh Namdari, A. Abedi
Objectives The purpose of this study was to compare the efficacy of integrated cognitive behavioral therapy with Transdiagnostic Treatment on symptoms of patients with generalized anxiety disorder comorbid with depression. Methods The quasi-experimental design of two groups (integrated cognitive behavioral therapy group, Transdiagnostic treatment group) was used for competitive validity. The statistical population included people with comorbid anxiety disorder with depression who referred to counseling centers in Isfahan in 1398, from which 10 people were selected by purposive sampling and randomly assigned to two groups. Research instruments were GAD7 scales, Beck Depression Inventory, and Penn State Worry Questionnaire (PSWQ). Results Visual charting, percentage of improvement, and reliable change index (RCI)) showed that both treatments produced clinically and statistically significant changes in therapeutic outcomes (symptoms of anxiety, worry and depressive symptoms) and continued therapeutic effects during follow-up. But the percentages of improvement in the integrated treatment group in all three components of symptoms of anxiety, worry and depression were higher. Conclusion Based on the obtained results and based on the Theoretical explanation of findings for effectiveness of therapy, integrated Cognitive Behavioral Therapy is preferred over transdiagnostic treatment in terms of the magnitude of change and stability, but both are similar in acceptance.
目的比较认知行为综合治疗与转诊治疗对广泛性焦虑症合并抑郁症患者症状的疗效。方法采用两组(综合认知行为治疗组、转诊治疗组)的准实验设计进行竞争有效性测试。统计人群包括1398年转诊到伊斯法罕咨询中心的焦虑症和抑郁症共病患者,其中10人通过有目的的抽样选择,随机分为两组。研究工具为GAD7量表、Beck抑郁量表和宾夕法尼亚州立大学焦虑问卷(PSWQ)。结果视觉图表、改善百分比和可靠变化指数(RCI)显示,两种治疗方法在治疗结果(焦虑、担忧和抑郁症状)方面都产生了临床和统计上的显著变化,并在随访期间继续发挥治疗效果。但综合治疗组在焦虑、担忧和抑郁三种症状中的改善百分比都更高。结论根据所获得的结果和对治疗有效性的理论解释,综合认知行为治疗在变化幅度和稳定性方面优于跨诊断治疗,但两者在接受程度上相似。
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引用次数: 1
Evaluation of the Efficacy and Safety of Pregabalin as an Adjuvant to Antipsychotics in Patients with Chronic Schizophrenia: A Six-Week Pilot Double-Blind Placebo-Controlled Trial 普瑞巴林辅助抗精神病药物治疗慢性精神分裂症的疗效和安全性评价:一项为期六周的双盲安慰剂对照试验
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.3.2167.3
S. Farnia
Introduction and objectives: Antipsychotics or dopamine receptor antagonists are the major components of treatment but about 10-20% of patients with schizophrenia do not benefit from treatment with antidopaminergic agents, indicating other neuronal systems may be involved in this disorder (2). Dysregulation of both excitatory and inhibitory mechanisms N-Methyl-D-aspartic acid (NMDA) and γ-Amino butyric acid (GABA) are implicated in psychopathology of schizophrenia (4). GABAergic neurons alter dopaminergic function by inhibiting presynaptic dopamine release, particularly in the mesolimbic system (5). As gabaergic drugs act on the mesoprefrontocortical region and reduce dopaminergic activity, they may reduce both the positive and negative symptoms of schizophrenia (5, 6). Pregabalin is a GABA structural analog that binds to the alpha-2/delta subunit of voltage-dependent calcium channels and regulates the release of neurotransmitters such as glutamate, noradrenaline, and substance P in hyperactive neurons too (4,10). The role of pregabalin as an adjunctive substance in the treatment of psychotic symptoms in patients with schizophrenia has been evaluated in few studies (4-6, 11). These trials were associated with contradictory results partly due to differences in the sample size, patientschr(chr('39')39chr('39')) antipsychotic regimen and severity of psychotic symptoms at baseline. This pilot double blind, randomized clinical trial study was designed to investigate the efficacy and safety of pregabalin add on standard antipsychotic treatment in patients with chronic schizophrenia for 6 weeks. Methods: In a randomized, double-blind, placebo-controlled clinical trial, 48 inpatient male patients aged 18 to 65 years who fulfilled the chronic schizophrenia diagnosis, based on the structured clinical interview developed by the criteria from DSM-5(12), and had received antipsychotics for at least two years and were clinically stable on their current antipsychotic agent (no change in medication/dose of current antipsychotic agent) for a minimum of three months included in the study in Sari, Mazandaran, Iran. Exclusion criteria were existence of serious medical, neurological or any other comorbid psychiatric disorders in terms of DSM-5, electroconvulsive therapy in the last 6 months, history of substance use disorder (including alcohol, but exept nicotine) as defined by DSM-5 and relapse within the past six months before the screening visit or positive urine test for illicit drugs prior to entering the trial, history of treatment with pregabalin during the past six months, and hypersensitivity to pregabalin and its derivatives or placebo. Also, patients received anticholinergic medication (biperiden or trihexyphenidyl) for extrapyramidal symptoms and lorazepam for agitation or insomnia, as benzodiazepine of choice in study centers prior to entering the trial, were included if being stable (no change in medication/dose) for a minimum of one month before starti
引言和目的:抗精神病药物或多巴胺受体拮抗剂是治疗的主要成分,但约10-20%的精神分裂症患者没有从抗多巴胺能药物的治疗中获益,这表明其他神经系统可能参与了这种疾病(2)。兴奋和抑制机制的失调N-甲基-D-天冬氨酸(NMDA)和γ-氨基丁酸(GABA)与精神分裂症的精神病理学有关(4)。GABA能神经元通过抑制突触前多巴胺的释放来改变多巴胺能功能,特别是在中边缘系统中(5)。由于GABA能药物作用于中前皮质区域并降低多巴胺能活性,它们可以减轻精神分裂症的阳性和阴性症状(5,6)。普瑞巴林是一种GABA结构类似物,与电压依赖性钙通道的α-2/δ亚基结合,并调节过度活跃神经元中谷氨酸、去甲肾上腺素和P物质等神经递质的释放(4,10)。普瑞巴林作为一种辅助物质在治疗精神分裂症患者精神病症状中的作用在少数研究中得到了评估(4-6,11)。这些试验的结果相互矛盾,部分原因是样本量、患者抗精神病药物方案和基线时精神病症状严重程度的差异。这项先导性双盲随机临床试验研究旨在研究普瑞巴林加用标准抗精神病药物治疗慢性精神分裂症患者6周的疗效和安全性。方法:在一项随机、双盲、安慰剂对照的临床试验中,48名18至65岁的男性住院患者符合慢性精神分裂症的诊断,基于DSM-5(12)标准制定的结构化临床访谈,接受抗精神病药物治疗至少两年,并且在伊朗马赞德兰Sari的研究中,对目前的抗精神病药(药物/剂量没有变化)临床稳定至少三个月。排除标准是在DSM-5、过去6个月内的电休克治疗、,DSM-5定义的物质使用障碍史(包括酒精,但不包括尼古丁),在筛选访视前的过去六个月内复发或进入试验前的非法药物尿检呈阳性,过去六个月中普瑞巴林治疗史,以及对普瑞巴林及其衍生物或安慰剂的超敏反应。此外,如果在研究开始前和研究期间至少一个月内病情稳定(药物/剂量不变),则纳入研究中心在进入试验前选择的抗胆碱能药物(比培林或苯甲酰肼)治疗锥体外系症状和劳拉西泮治疗躁动或失眠的患者。抗精神病药物及其剂量在研究期间是恒定的。在给予知情同意后,参与者被分为4组,并使用计算机随机数生成器以1:1的比例随机分组,接受普瑞巴林或安慰剂治疗。干预组患者接受普瑞巴林(Sobhan Co,德黑兰,伊朗),如果耐受,初始剂量为75mg/d,持续三周;在第四周增加到150 mg/d,并与抗精神病药物方案一起持续6周,直到研究结束。安慰剂组的患者接受了相同的胶囊(与普瑞巴林具有相同的形状、颜色和味道)以及抗精神病药物治疗6周。PANSS评价治疗效果。锥体外系症状采用Barnes Akathia量表(BARS)(16)和Simpson-Angus量表(SAS)(17)进行评估。在用药开始后的第3周和第6周对患者进行基线评估。在SPSS软件版本20中使用ANOVA和重复测量对收集的数据进行分析,p值小于0.05被认为具有统计学意义。结果:在基线时,两组之间的人口统计学或临床变量没有观察到显著差异。在研究的第3周和第6周,两组之间的PANSS总分、阳性、阴性和一般精神病理学分量表得分差异不显著。此外,两种方案在研究第3周和第6周的SAS和BARS评分以及两组之间其他不良反应的频率方面的差异也不显著(表1)。讨论:这项研究的结果表明,在慢性精神分裂症患者的标准抗精神病药物治疗中,每天添加150 mg普瑞巴林对改善精神病症状的益处并不比安慰剂大。 普瑞巴林治疗与类似于安慰剂的不良事件发生率相关,其中大多数是轻度不良事件。150 mg普瑞巴林加用抗精神病药物是安全且耐受性良好的。据我们所知,在少数研究中评估了普瑞巴林添加抗精神病药物对精神分裂症患者的有效性,并在这方面取得了不同的结果(4-1,11)。目前关于精神病症状的研究结果与Javahery等人的研究结果一致。(6)与Schönfeldt Lecuona等人的研究形成对比。(5)和Englisch等人(4)。这种差异可能是由于研究类型、普瑞巴林剂量、样本量、患者抗精神病药物方案和基线时精神病症状严重程度的差异。普瑞巴林耐受性良好,研究期间未出现新的精神病症状或精神病症状恶化(7,8,14,22,23)。尽管如此,这项研究可能相对较小,以确定副作用率的差异。本研究的局限性是普瑞巴林滴定率高,这缩短了患者、研究时间短和男性患者接受全剂量普瑞巴林的持续时间。有必要对男女精神分裂症患者进行更大样本量、更长持续时间、不同普瑞巴林剂量方案的进一步研究,以确认或拒绝本研究的结果。结论:我们的研究结果不支持普瑞巴林作为精神分裂症患者精神病症状的辅助治疗的临床作用。
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引用次数: 0
The Study of Psychometric Properties of the Persian Version of the Patient Health Questionnaire-9 (PHQ-9) Among Students of Guilan University of Medical Sciences in the Academic Year 2017-18 2017-18学年桂兰医科大学学生波斯版PHQ-9患者健康问卷的心理测量特性研究
IF 0.9 Q4 PSYCHIATRY Pub Date : 2021-03-13 DOI: 10.32598/IJPCP.27.2.3375.1
H. Farrahi, B. Gharraee, M. Oghabian, R. Zare, M. Pirmoradi, Seyed Moteza Najibi, S. A. Batouli
Objectives: The Patient Health Questionnaire-9 (PHQ-9) is one of the most commonly used measures for screening, diagnosing and monitoring of depression treatment. So far, four studies in Iran have examined some of its psychometric properties in the population of medical and psychiatric patients - however, some aspects of its psychometrics and in the student population have not yet been adequately evaluated. The aim of this study is to examine more aspects of psychometric characteristics of PHQ-9 in Iran with a focus on the student population. Methods: In a descriptive study, 463 students of Guilan University of Medical Sciences in the academic year 2017-18were selected using convenience sampling and completed the research measures. The reliability of the Persian version of PHQ-9 was assessed using internal consistency and test-retest with two week interval. Its construct validity in the sample of students was evaluated by exploratory and confirmatory factor analyses. To evaluate its convergent validity, the second version of the Beck Depression Inventory (BDI-II), the depression subscale of the 21-item Depression Anxiety Depression Inventory (DASS-21), the neuroticism subscale of NEO Five Factor Inventory (NEO-FFI) and the negative affect subscale of the Positive Affect and Negative Affect Scale (PANAS) were used. The openness subscale of NEO-FFI and the positive affect subscale of PANAS were also used to assess the discriminant validity. Results: According to the findings, Cronbachchr('39')s alpha coefficient of 0.856 and intraclass correlation coefficient of 0.869 indicated, respectively, internal consistency and high test-retest reliability of PHQ-9. Exploratory factor analysis found that all questions were in one factor, accounting for 47.59% of the total variance. Confirmatory factor analysis showed that all questions were related to one factor. Positive correlation of PHQ-9 with BDI-II (r = 0.769), the neuroticism subscale of NEO-FFI (r = 0.508), the depression subscale of DASS-21 (r = 0.647) and the negative affect subscale of PANAS (r = 0.430) represented the convergent validity and its negative correlation with the positive affect subscale PANAS (r = -0.444) indicated its discriminant validity, while the openness subscale of NEO indicates NEO-FFI (r = 0.116) did not show a significant relationship. Conclusion: Overall, the findings of the present study suggest that PHQ-9 as a short-term measure has the potential to be used in clinical and research domains to screen, diagnose, and monitor clinical and/or subclinical depression in the student population.
目的:患者健康问卷-9(PHQ-9)是筛查、诊断和监测抑郁症治疗最常用的方法之一。到目前为止,伊朗的四项研究已经在医学和精神病患者群体中检验了它的一些心理测量特性——然而,它的心理测量和学生群体中的某些方面尚未得到充分评估。本研究的目的是检验伊朗PHQ-9的心理测量特征的更多方面,重点是学生群体。方法:采用描述性研究方法,采用方便抽样法,选取桂兰医科大学2017-18学年的463名学生,完成研究措施。波斯版PHQ-9的可靠性通过内部一致性和间隔两周的重新测试进行评估。通过探索性和验证性因素分析对其在学生样本中的结构有效性进行了评价。为了评估其收敛有效性,使用了第二版贝克抑郁量表(BDI-II)、21项抑郁-焦虑-抑郁量表的抑郁分量表(DAS-21)、NEO五因素量表的神经质分量表(NEO-FFI)和积极情感和消极情感量表的消极情感分量表(PANAS)。NEO-FFI的开放性分量表和PANAS的积极情感分量表也用于评估判别有效性。结果:根据研究结果,Cronbachchhr(‘39’)的α系数为0.856,组内相关系数为0.869,分别表明PHQ-9的内部一致性和高的重测可靠性。探索性因素分析发现,所有问题都在一个因素中,占总方差的47.59%。验证性因素分析表明,所有问题都与一个因素有关。PHQ-9与BDI-II呈正相关(r=0.769)、NEO-FFI的神经质分量表(r=0.508)、DAS-21的抑郁分量表(r=0.647)和PANAS的负情感分量表(P=0.430)表示收敛有效性,与PANAS的正情感分量表呈负相关(r=-0.444)表示判别有效性,而NEO开放度分量表表明NEO-FFI(r=0.116)没有显示出显著的相关性。结论:总体而言,本研究的结果表明,PHQ-9作为一种短期测量方法,有可能在临床和研究领域用于筛查、诊断和监测学生群体中的临床和/或亚临床抑郁症。
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引用次数: 9
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Iranian Journal of Psychiatry and Clinical Psychology
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