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Correlation of Radiological Findings (High Resolution Computed Tomography Chest) with Anti-SARS-COV-2 Antibodies in Patients Visiting Tertiary Care Hospitals 三级医院患者胸片影像学表现(高分辨率ct)与抗sars - cov -2抗体的相关性
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-08-03 DOI: 10.21649/akemu.v28i2.5092
A. Jaleel, Mazhar Shafique, Samar Asim, Kiran Namoos, Sadaf Saleem Uppal, Saleem Pervaiz
Background: Coronavirus (COVID 19) pandemic has taken so many lives and has contributed to an increase in morbidity due to its complications. The research is still in infancy and much has yet to be investigated. Objective: To correlate the HRCT findings on chest with antibody testing in patients visiting tertiary care hospitals in Lahore. Methodology: Three hundred and thirty-two patients with mild, moderate and severe symptoms of COVID 19 were recruited. Those with raised CRP levels were sent for HRCT chest and PCR testing as protocol of the hospitals. All patients were tested with Rapid antibody kits for reactivity. Results: Showed that males were affected more than females. Similarly, non-health care workers were more affected. All patients with bilateral involvement of lungs on HRCT chest and positive PCR findings also tested reactive on antibody testing. However, a few people with bilateral lung involvement and negative on PCR testing got reactive results on Rapid antibody testing. Linear regression model shows significant correlation of HRCT chest findings with Ant-SARC- COV 2 antibodies. Conclusion: HRCT findings (Unilateral and bilateral lung infiltrates) correlated significantly with Anti SARC-COV 2 Antibodies.
背景:冠状病毒(COVID - 19)大流行夺走了许多人的生命,并因其并发症导致发病率上升。这项研究仍处于起步阶段,还有很多需要调查。目的:探讨拉合尔三级医院患者胸部HRCT表现与抗体检测的相关性。方法:招募新冠肺炎轻、中、重度症状患者332例。CRP水平升高的患者作为医院的协议送去做HRCT胸部和PCR检测。所有患者均采用快速抗体试剂盒检测反应性。结果:男性发病多于女性。同样,非卫生保健工作者受到的影响更大。所有HRCT胸部双侧肺受累和PCR阳性的患者在抗体检测中也检测出反应性。然而,少数双肺受累和PCR检测阴性的患者在快速抗体检测中出现反应性结果。线性回归模型显示HRCT胸部表现与抗sarc - COV 2抗体有显著相关性。结论:HRCT表现(单侧和双侧肺浸润)与抗SARC-COV 2抗体有显著相关性。
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引用次数: 0
Validity of Pediatric Emergency Care Applied Research Network (PECARN) in Pediatric Trauma Patients - A Cross Sectional Study from a Tertiary Care Hospital in Pakistan 儿科急诊应用研究网络(PECARN)在儿科创伤患者中的有效性——来自巴基斯坦一家三级医院的横断面研究
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-05-23 DOI: 10.21649/akemu.v28i1.4994
Naureen Naseer, N. Kapadia, Sarwat Masud
Introduction: Head trauma in the pediatric age group is a common presentation in the Emergency Room (ER). ThePediatric Emergency Care Applied Research Network (PECARN) tool can help an ER clinician to identify pediatric headtrauma patients at very low risk of clinically important traumatic brain injuries (ciTBIs) and avoid unnecessary CT scans.Objective: To determine the validity of PECARN rule as compared to the head CT (gold standard) in identifying low risktraumatic brain injury pediatric patients. Methods: A cross-sectional study was done at Aga Khan University Hospital (AKUH) Emergency Department ED. All pediatric head trauma patients were included in this study between 2017-2019. A total of 218 head trauma cases were reviewed which were evaluated for the PECARN criteria. Data were extracted on a prepared data collection form. Data were entered and analyzed using SPSS. Chi-square test was used. Results: Among the total 218, 190 cases (87%) had CT scans ordered. Out of these 190 patients 156 (82%) met PECARN criteria, while 34 (18%) were PECARN negative. The sensitivity and specificity of PECARN was calculated as 82% and 33% respectively, with a fair level of agreement with CT scan based on Kappa statistics. Conclusion: PECARN has a higher sensitivity but lower specificity in comparison to CT scan. 
简介:头部创伤在儿科年龄组是一个常见的表现在急诊室(ER)。儿科急诊应用研究网络(PECARN)工具可以帮助急诊室临床医生识别临床重要创伤性脑损伤(ciTBIs)风险极低的儿科颅脑损伤患者,并避免不必要的CT扫描。目的:比较PECARN规则与头颅CT(金标准)鉴别低风险颅脑损伤患儿的有效性。方法:在阿迦汗大学医院(AKUH)急诊科进行了一项横断面研究。该研究纳入了2017-2019年期间所有儿科头部创伤患者。总共218例头部创伤病例进行了审查,并根据PECARN标准进行了评估。数据从准备好的数据收集表上提取。数据录入并使用SPSS进行分析。采用卡方检验。结果:218例患者中,190例(87%)行CT扫描。在这190例患者中,156例(82%)符合PECARN标准,34例(18%)为PECARN阴性。PECARN的敏感性和特异性分别为82%和33%,根据Kappa统计与CT扫描具有相当的一致性。结论:PECARN与CT扫描相比具有较高的敏感性和较低的特异性。
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引用次数: 0
Implementation of National Licensing Examination (NLE) and its Impact on Global Healthcare: A Systematic Review 国家执业资格考试(NLE)的实施及其对全球医疗保健的影响:系统回顾
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-05-10 DOI: 10.21649/akemu.v28i1.5022
Shehzad Saleem, S. Afzal
Background: A license required for full practice - National licensing examinations (NLEs) are required in most of the countries with well-established medical regulatory authorities. Objective: This systematic review aims to investigate the impact of NLEs after their implementation worldwide. Methods: Systematic review designed as per Kane's validity framework developed by Olivary et al. by exploring online databases such as: Wiley Online, Embase Medline (EBSCO); PubMed; JSTOR; Google Scholar and Science Direct; from January 2005 to December 2020. Results: NLE exams and better patient outcomes (communication, satisfaction) are positively related and such exams help in development of a common medical curriculum and a better post-graduation entry point. Conclusions: In the present era, where more medical graduates are flying all across the globe for employment than ever before, NLE is becoming inevitable and helps to ensure that medical training satisfies a minimum standard of quality, which varies among Medical schools and colleges within a country and globally. Continual improvement is crucial for the identification of gaps in the medical licensing exams. The license holders must comply with National authorities and stay active in academic and clinical activities to stay licensed.
背景:全面执业需要执照-在大多数具有完善的医疗监管当局的国家,都需要国家执照考试(NLEs)。目的:本系统综述旨在探讨NLEs在全球范围内实施后的影响。方法:根据Olivary等人开发的Kane效度框架设计的系统评价,通过探索在线数据库,如:Wiley online, Embase Medline (EBSCO);PubMed;JSTOR;Google Scholar和Science Direct;2005年1月至2020年12月。结果:NLE考试与更好的患者预后(沟通,满意度)呈正相关,此类考试有助于制定共同医学课程和更好的毕业后入门点。结论:在当今时代,越来越多的医学毕业生在全球各地就业,NLE是不可避免的,它有助于确保医学培训满足最低质量标准,这在一个国家和全球的医学院和学院之间是不同的。持续改进对于确定医疗执照考试中的差距至关重要。许可证持有人必须遵守国家当局的规定,并积极参加学术和临床活动,以保持许可证。
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引用次数: 1
Pregnancy Outcome in Acute Viral Hepatitis E 急性病毒性戊型肝炎的妊娠结局
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-05-09 DOI: 10.21649/akemu.v28i1.5006
Rashida Sultana, S. Humayun, Sofia Manzoor, S. Humayun
Background: Hepatitis E is associated with poor feto-maternal outcome. Patients with acute hepatitis E who are pregnant usually require hospital admission and monitoring with liver function tests and clotting profile. Objective: To evaluate maternal and fetal outcome among pregnant women who have positive serology for hepatitis E IgM. Methods: Data of women with clinical presentation of jaundice during pregnancy and who were diagnosed as acute hepatitis E was collected on pre-structured questionnaire after obtaining consent. Data were entered in Statistical Package for Social Sciences for analysis. Results: Three hundred and thirty three women had positive serology for hepatitis E IgM. Out of these three hundred were in last trimester of their pregnancy. The gestational age of two hundred and thirty two (77%) women was less than 37 weeks at presentation. Six (2%) pregnancies ended up in miscarriage, fifty four (16 %) had fetal demise in maternal womb while two hundred and seventy three (82%) were viable fetus. One third of live born babies were kept in NICU. Indications of neonatal admission were respiratory distress in 57(72%), jaundice neonatorum in 12(15%), asphyxia neonatorum in 9(12%), while one (1%) had transient tachypnea. Neonates who died in first week of their life were 18(23%).The cause of neonatal death was respiratory distress in 12 (67%) and anoxia in remaining 6 (33%) neonates. Most of the women were discharged home however maternal mortality was recorded in 80(24%) patients, mainly in postpartum period 73(91%). Conclusion: Pregnant women with acute hepatitis E have more complicated course of this viral infection with adverse fetal and maternal implications.
背景:戊型肝炎与不良的胎母结局有关。妊娠期急性戊型肝炎患者通常需要住院并进行肝功能检查和凝血监测。目的:评价戊型肝炎IgM血清学阳性孕妇的母胎结局。方法:对临床表现为妊娠期黄疸并经诊断为急性戊型肝炎的妇女,在征得同意后,采用预先编制的问卷收集资料。数据输入《社会科学统计资料包》进行分析。结果:333名妇女血清E型肝炎IgM阳性。其中三百人处于怀孕的最后三个月。232例(77%)孕妇在分娩时的胎龄小于37周。6例(2%)妊娠以流产告终,54例(16%)胎儿在母体子宫内死亡,273例(82%)胎儿存活。三分之一的活产婴儿被关在新生儿重症监护室。新生儿入院指征为呼吸窘迫57例(72%),新生儿黄疸12例(15%),新生儿窒息9例(12%),短暂性呼吸急促1例(1%)。出生后第一周死亡的新生儿有18例(23%)。12例(67%)新生儿死于呼吸窘迫,其余6例(33%)新生儿死于缺氧。大多数妇女出院回家,但产妇死亡率有80例(24%),主要发生在产后73例(91%)。结论:孕妇急性戊型肝炎病程复杂,对胎儿和母体均有不良影响。
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引用次数: 0
Comparison of Sublingual & Per Rectal Misoprostol versus Oxytocin in the Prevention of Postpartum Hemorrhage 米索前列醇与催产素在预防产后出血中的作用比较
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-05-09 DOI: 10.21649/akemu.v28i1.5029
Wafa Najeeb, Rabia Shahid, Sadia Sharif, Sana Danish, A. Masood, Mansab Ali
Abstract: Background: Postpartum Hemorrhage (PPH) is the most common reason of maternal death globally. Misoprostol and oxytocin are two first line and effective management protocols. But controversies exist in literature. For that matter, this study was conducted. Objectives: To compare the frequency of postpartum hemorrhage with per rectal misoprostol in relation to intramuscular oxytocin in females undergoing normal vaginal delivery at term. Methods: This randomized controlled trial was conducted in Department of Obstetrics & Gynaecology, Sheikh Zayed Hospital, Lahore from 01-01-2019 to 01-12-2019. Patients were divided randomly into equal halves through the lottery method. Group A received Misoprostol and group B received Oxytocin. Medications were administered within one minute of clamping and the cutting of cord. During 24 hours, soaked pads were evaluated for blood loss and total blood loss was calculated. If blood loss>500ml, then PPH was labeled. Results: Mean age of women in Group A and in Group-B were 29.11±6.67 and 29.23±6.70 years. The mean gestational age for Group A came as 39.60±1.78 weeks and for Group-B, it was 39.53±1.72. In Group-A 24(15.7%) and in Group-B 59(38.6%) women suffered from PPH. PPH was significantly lower in comparison to the women in Group-B. Pvalue=0.000. Conclusion: Results of this study showed that use of per rectal Misoprostol is more suitable and effective in the prevention of Post-partum hemorrhages compared to oxytocin in females undergoing normal vaginal delivery at term.
摘要:背景:产后出血(PPH)是全球最常见的孕产妇死亡原因。米索前列醇和催产素是两种一线有效的治疗方案。但在文学中存在争议。就此而言,这项研究是进行的。目的:比较经直肠米索前列醇与肌内催产素对足月正常阴道分娩女性产后出血的影响。方法:本随机对照试验于2019年1月1日至2019年1月12日在拉合尔Sheikh Zayed医院妇产科进行。通过摇号法将患者随机分成两半。A组给予米索前列醇,B组给予催产素。在夹紧和剪断脐带后一分钟内给药。在24小时内,评估湿垫的失血量并计算总失血量。若失血量>500ml,则标记PPH。结果:A组和b组女性平均年龄分别为29.11±6.67岁和29.23±6.70岁。A组平均胎龄为39.60±1.78周,b组平均胎龄为39.53±1.72周。a组24例(15.7%),b组59例(38.6%)。与b组相比,PPH明显降低。Pvalue = 0.000。结论:本研究结果表明,在正常阴道足月分娩的女性中,使用经直肠米索前列醇比使用催产素更适合和有效地预防产后出血。
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引用次数: 0
Comparison of Low Dose Albumin Versus Full Dose Albumin in Improving Refractory Ascites in Cirrhotic Patients 低剂量白蛋白与全剂量白蛋白改善肝硬化难治性腹水的比较
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-04-30 DOI: 10.21649/akemu.v28i1.5015
Maaz Ahmed, Zafar Niaz, S. Mumtaz, S. Lodhi, Aneeza Munir, S. Abaidullah
Background: Refractory ascites is one of the most important complications of cirrhosis & albumin is considered highly effective in controlling it. Objective: To compare efficacy of 10g albumin versus 20g albumin in improving refractory ascites in cirrhotic patients. Methods: This randomized control trial was conducted at department of Gastroenterology, Mayo hospital Lahore for 12 months. After ethical approval, 60 patients of chronic liver disease with refractory ascites were included in the study & were divided into two groups. Group A was administered with 20g albumin whereas; group B was given 10g albumin. Both groups were followed for next 3 days by measuring change in weight, abdominal girth and urine output. Data was analyzed by using SPSS v-21. Results: There was no considerable difference between two groups regarding change in weight, abdominal girth and urine output. There was no significant difference in albumin response for both the groups in reducing ascites (p=0.6022). Conclusion: Low dose albumin is as effective as full dose albumin for reducing refractory ascites among cirrhotic patients.
背景:顽固性腹水是肝硬化最重要的并发症之一,白蛋白被认为对其控制非常有效。目的:比较10g白蛋白与20g白蛋白治疗肝硬化难治性腹水的疗效。方法:在拉合尔梅奥医院消化内科进行为期12个月的随机对照试验。经伦理批准,将60例慢性肝病合并难治性腹水患者纳入研究,并分为两组。A组给予白蛋白20g;B组给予白蛋白10g。两组随访3 d,测量体重、腹围、尿量变化。数据分析采用SPSS v-21软件。结果:两组患者的体重、腹围和尿量变化无显著差异。两组在减少腹水方面的白蛋白反应无显著差异(p=0.6022)。结论:低剂量白蛋白治疗肝硬化难治性腹水与全剂量白蛋白治疗效果相同。
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引用次数: 0
Mast Cells Released Inflammatory Markers Play a Vital Role in Mandibular Remodeling of Odontogenic Keratocyst Patients 肥大细胞释放的炎症标志物在牙源性角化囊肿患者的下颌重塑中起重要作用
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-04-30 DOI: 10.21649/akemu.v28i1.4991
Z. Malik, A. Mirza, M. Akram, Adnan Arshad, A. Kiyani
Background: Odontogenic Keratocyst (OKC) falls among the distinctive and rare odontogenic developmental cyst which is derivative of the dental lamina and contains clear fluid along with a cheesy material which resembles keratin debris.  Treatment strategies for OKC are for the most part classified as conservative or aggressive. Mast Cells play an important role in the pathogenesis of inflammatory conditions. Objective: The goal of our study was to observe the participation of inflammatory mediators (RANKL, TNF-α, TGF-β and MMP-9) in the pathogenesis as well as the recovery process of OKC. Methods: Enrolled patients were divided into three groups while a fourth group was formed of the control individuals. Sampling of all groups was done once after required data collection. Blood samples were taken, mRNA extraction and cDNA was then subjected to qRT-PCR. IHC for mast cells was done on patient samples. Results: qRT-PCR showed higher expressions of inflammatory markers in patients undergoing treatment as compared to individuals with completed treatment procedure. Levels of RANKL were high in patients that were currently undergoing bone development as compared to other patients. The levels of TNF-α were comparatively higher in patients who  showed visible signs of inflammation like swelling and pain. TGF-β and MMP-9 expression levels showed correlation with each other in all three groups. Both these cytokines were also found to be in association with mast cells. The results of histochemical staining of mast cells suggested the involvement of these cells in the pathogenesis of the cystic lesion via inflammation. Conclusions: The findings of the study suggest that the expressions of inflammatory mediators correlate with the presence of mast cells, therefore, application of mast cells stabilizers in addition to marsupialization in the treatment of OKC can be a prospective treatment strategy in future clinical settings.
背景:牙源性角化囊肿(OKC)是一种独特而罕见的牙源性发育性囊肿,它是牙板的衍生物,含有透明的液体和类似角蛋白碎片的奶酪状物质。OKC的治疗策略在很大程度上分为保守和积极两类。肥大细胞在炎症的发病机制中起着重要作用。目的:我们的研究目的是观察炎症介质(RANKL、TNF-α、TGF-β、MMP-9)在OKC发病和恢复过程中的参与情况。方法:入组患者分为三组,第四组为对照组。在收集所需数据后,对所有组进行一次抽样。采集血样,提取mRNA,进行qRT-PCR检测cDNA。对患者样本进行肥大细胞免疫组化。结果:qRT-PCR显示,与完成治疗程序的个体相比,接受治疗的患者炎症标志物的表达更高。与其他患者相比,目前正在进行骨发育的患者的RANKL水平较高。在出现肿胀和疼痛等明显炎症症状的患者中,TNF-α水平相对较高。TGF-β和MMP-9在三组中表达水平均具有相关性。这两种细胞因子也被发现与肥大细胞有关。肥大细胞的组织化学染色结果表明这些细胞通过炎症参与了囊性病变的发病机制。结论:研究结果表明炎症介质的表达与肥大细胞的存在相关,因此,肥大细胞稳定剂和有袋化在OKC治疗中的应用可能是未来临床环境中的一种前瞻性治疗策略。
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引用次数: 0
Behavioural Determinants for Hand Hygiene Practices among Primary School Children during COVID-19 Pandemic COVID-19大流行期间小学生手部卫生习惯的行为决定因素
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-04-30 DOI: 10.21649/akemu.v28i1.5019
M. T. Rana, M. Afzal, M. Hamid
Background: Children acquire SARS CoV-2 infection from their family members but they experience mild symptoms. Hand washing promotion programs are being executed in many countries to enhance child healthcare development. Objective: This study was designed to identify behavioural determinants to increase hand washing practices among primary school children during COVID-19 pandemic. Methods: This was a cross-sectional study conducted by the Department of Pediatrics, King Edward Medical University/ Mayo Hospital, Lahore from June to November 2020. Total of 195 mothers of primary school children were enrolled by non-probability consecutive sampling. A 23-item, 5 points likert scale questionnaire assessed 5 domains related to handhygiene. Data was entered in SPSS 24. Domains were presented as frequency tables. Independent sample t-test was applied to 8 mean score of sub-category of each domain, and to cumulative mean score of each domain. A cut off mean score of ≥3 was taken as satisfactory. Results: We found satisfactory mean scores amongst mothers for knowledge regarding the importance of hand-washing (3.59±0.62), and commitment regarding maintenance of hand-hygiene (3.44±0.773). Better mean score for liking hand washing with alcohol rub/sanitizer than with soap and water (3.14±1.063 versus 1.10±1.229) was seen. Children reported not feeling dirty if they did not practice hand-hygiene (2.99±1.195). Elders in the households promoted hand-washing, but lacked practicing it themselves (3.48±0.881 versus 2.85±1.242). There was below satisfactory mean score for hand-hygiene amongst children after sneezing, coughing, blowing their nose, or playing (2.50±1.253, 2.23±1.265, 2.27±1.301, 2.83±1.280 respectively). Norm and self-efficacy factors had adequate overall scores (3.17±0.84, 3.17±0.65). The total score for this study was 2.8759±0.419. Conclusion: We found satisfactory mean scores for risk, attitudes, norms, ability, and self-regulation factors of handhygiene among primary school children.
背景:儿童从家庭成员处感染SARS CoV-2,但症状较轻。许多国家正在执行促进洗手的方案,以加强儿童保健的发展。目的:本研究旨在确定在COVID-19大流行期间增加小学生洗手习惯的行为决定因素。方法:这是一项横断面研究,由拉合尔爱德华国王医科大学/梅奥医院儿科于2020年6月至11月进行。采用非概率连续抽样方法,对195名小学生母亲进行调查。一份包含23个项目、5分李克特量表的问卷评估了与手卫生相关的5个领域。数据在SPSS 24中输入。域以频率表的形式表示。每个域的8个子类别的平均得分和每个域的累积平均得分采用独立样本t检验。以截断平均得分≥3分为满意。结果:母亲对洗手重要性知识的平均得分为3.59±0.62,对保持手卫生的承诺的平均得分为3.44±0.773。喜欢用酒精搓手液/消毒液洗手的平均得分高于肥皂和水洗手的平均得分(3.14±1.063比1.10±1.229)。儿童报告说,如果他们不进行手部卫生,他们不会感到脏(2.99±1.195)。家庭长辈提倡洗手,但缺乏实际洗手(3.48±0.881比2.85±1.242)。儿童在打喷嚏、咳嗽、擤鼻涕和玩耍后的手卫生平均得分分别为2.50±1.253、2.23±1.265、2.27±1.301、2.83±1.280,均低于满意水平。规范因子和自我效能因子的总得分为3.17±0.84分,3.17±0.65分。本研究总得分为2.8759±0.419。结论:小学生手卫生的风险、态度、规范、能力和自我调节因素的平均得分令人满意。
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引用次数: 0
The Analysis of Published Research on Gout and Hyperuricemia from Pakistan in National Biomedical Literature 巴基斯坦国家生物医学文献中发表的痛风和高尿酸血症研究分析
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-04-30 DOI: 10.21649/akemu.v28i1.5020
F. Rathore, Amara Ilyas, F. Farooq
Objective: This study analyzed the published research on gout and hyperuricemia in the national biomedical journals with an aim to highlight the research gaps in the management of gout and hyperuricemia in Pakistan. Methods: An online literature survey on global databases (Medline and Google Scholar) and local Pakistani database Pak Medinet was conducted from January to March 2018. Different keywords on gout and hyperuricemia in Pakistan were combined using Boolean operators. We included all kinds of manuscripts reporting work specifically related to gout or hyperuricemia from Pakistan and having the corresponding author or at least one author with an affiliation from a Pakistani institution. We also considered manuscript published on this topic in Pakistani journals by authors affiliated with other countries. Results: Thirty-four manuscripts were selected for review and analysis. Thirty-one manuscripts were written by local authors affiliated with institutions located in different cities of Pakistan. Five manuscripts had foreign authors, out of which two were authored by all Turkish authors, but others had Pakistani co- authors too. Most of the Manuscripts were published in the category of original research article. None of them was a randomized clinical trial (RCT). Conclusion: The number and quality of studies published on gout and hyper-uricemia from Pakistan is low. There is a need to conduct more epidemiological and interventional studies to know the actual burden of gout in the country and RCTs to compare different drug treatments for managing gout in the local population.
目的:本研究分析了在国家生物医学期刊上发表的痛风和高尿酸血症的研究,旨在突出巴基斯坦痛风和高尿酸血症管理方面的研究空白。方法:2018年1 - 3月对全球数据库(Medline和Google Scholar)和巴基斯坦本地数据库Pak Medinet进行在线文献调查。采用布尔运算符对巴基斯坦痛风和高尿酸血症的不同关键词进行组合。我们纳入了所有与巴基斯坦痛风或高尿酸血症相关的报告工作的手稿,并有通讯作者或至少一名作者与巴基斯坦机构有联系。我们还考虑了与其他国家有关联的作者在巴基斯坦期刊上发表的关于这一主题的手稿。结果:选取34篇文献进行综述分析。31份手稿是由隶属于巴基斯坦不同城市机构的当地作者撰写的。五份手稿有外国作者,其中两份是由所有土耳其作者撰写的,但其他手稿也有巴基斯坦的合著者。论文以原创性研究文章为主。没有一项是随机临床试验(RCT)。结论:在巴基斯坦发表的关于痛风和高尿酸血症的研究数量和质量都很低。有必要进行更多的流行病学和干入性研究,以了解该国痛风的实际负担,并进行随机对照试验,以比较当地人群中不同的药物治疗方法。
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引用次数: 0
Osteolytic Skull Lesions: Rare Finding in a Patient Presenting with Clinical Features of Progressive Multifocal Leukoencephalopathy (PML) With Unknown HIV Status 溶骨性颅骨病变:罕见发现的患者表现为进行性多灶性脑白质病(PML)的临床特征与未知的HIV状态
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2022-04-30 DOI: 10.21649/akemu.v28i1.5021
Safia Bano, Zomer Sardar, M. Kalim, A. Numan
Bacillary angiomatosis (BA) is a rare but an infrequent opportunistic infection reported mostly in HIV-infected patients. The most common site of involvement is the skin manifestation followed by solid organs involvement like liver and bone. Although most cutaneous manifestations are treatable, the other organs involvement can be fatal in some cases. We report a case of an isolated osteolytic lesion due to the Bacillary angiomatosis (BA). We conclude that Bacillary angiomatosis (BA) should be suspected and screened when an osteolytic bone lesion is identified in immunocompromised patients like HIV with or without cutaneous manifestations as it is deadly fatal if treatment is not given.
细菌性血管瘤病(BA)是一种罕见但不常见的机会性感染,主要发生在hiv感染者中。最常见的受累部位是皮肤,其次是肝脏和骨骼等实体器官。虽然大多数皮肤的表现是可以治疗的,但在某些情况下,累及其他器官可能是致命的。我们报告一例孤立的溶骨性病变,由于细菌性血管瘤病(BA)。我们的结论是,当免疫功能低下的患者(如有或无皮肤表现的HIV)发现溶骨性骨病变时,应怀疑和筛查细菌性血管瘤病(BA),因为如果不给予治疗,它是致命的。
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引用次数: 0
期刊
Annals of King Edward Medical University Lahore Pakistan
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